# gwascat

dbdate: 2011-10-07
author: Bis JC
date: 2011-09-11
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21909108
trait: Carotid intima media thickness
initial_samplesize: Up to 31,211 European ancestry individuals
replication_samplesize: 11,273 European ancestry individuals
region: 8q24.13
chrom: 8
reported_genes: ZHX2
mapped_gene: MRPS36P3 - CDK5PS
upstream_gene_id: 347704
downstream_gene_id: 392265
strongest_risk_snp: rs11781551
strongest_risk_allele: A
snps: rs11781551
snp_id_current: 11781551
context: Intergenic
pvalue_mlog: 10.69897000433602
ci_95: [0.01-0.01] unit decrease
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Meta-analysis of genome-wide association studies from the CHARGE consortium identifies common variants associated with carotid intima media thickness and plaque.


dbdate: 2011-10-11
author: Kim YJ
date: 2011-09-11
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21909109
trait: Gamma glutamyl transpeptidase
initial_samplesize: 12,545 Korean ancestry individuals
replication_samplesize: Up to 30,395 East Asian ancestry individuals
region: 4q31.22
chrom: 4
reported_genes: ZNF827
mapped_gene: ZNF827
snp_gene_ids: 152485
strongest_risk_snp: rs4835265
strongest_risk_allele: T
snps: rs4835265
snp_id_current: 4835265
context: intron
pvalue_mlog: 14
ci_95: [0.0031-0.0055] IU/L decrease
platform: Affymetrix [~2.2 million] (imputed)
cnv: N
study:
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.


dbdate: 2011-10-06
author: Lemaire SA
date: 2011-09-11
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21909107
trait: Thoracic aortic aneurysms and dissections
initial_samplesize: 765 European ancestry cases, 874 European ancestry controls
replication_samplesize: 548 European ancestry cases, 626 European ancestry controls
region: 15q21.1
chrom: 15
reported_genes: FBN1
mapped_gene: FBN1
snp_gene_ids: 2200
strongest_risk_snp: rs1036476
snps: rs1036476
snp_id_current: 1036476
context: intron
pvalue_mlog: 12.22184874961636
ci_95: [NR]
platform: Illumina [NR] (imputed)
cnv: N
study:
Genome-wide association study identifies a susceptibility locus for thoracic aortic aneurysms and aortic dissections spanning FBN1 at 15q21.1.


dbdate: 2011-10-11
author: Wain LV
date: 2011-09-11
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21909110
trait: Blood pressure
initial_samplesize: 74,064 European ancestry individuals
replication_samplesize: 48,607 European ancestry individuals
region: 2q24.3
chrom: 2
reported_genes: FIGN
mapped_gene: FIGN - PRPS1P1
upstream_gene_id: 55137
downstream_gene_id: 100861436
strongest_risk_snp: rs13002573
strongest_risk_allele: G
snps: rs13002573
snp_id_current: 13002573
context: Intergenic
pvalue_mlog: 7.698970004336018
ci_95: [0.20-0.42] mmHg decrease
platform: Affymetrix, Illumina, and Perlegen [NR] (imputed)
cnv: N
study:
Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.


dbdate: 2011-10-01
author: Chen D
date: 2011-09-10
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21896673
study: Genome-wide association study of HPV seropositivity.
trait: HPV seropositivity
replication_samplesize: 1,307 Hispanic head and neck cancer cases, 1,037 Hispanic controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DQB1
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs9357152
strongest_risk_allele: G
snps: rs9357152
snp_id_current: 9357152
pvalue_mlog: 14
platform: Illumina [316,015]
cnv: N
initial_samplesize:
1,286 European ancestry lung cancer cases, 679 European ancestry head and neck cancer cases, 811 European ancestry kidney cancer cases, 2,035 European ancestry controls


dbdate: 2011-09-30
author: Cai Q
date: 2011-09-09
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21908515
trait: Breast cancer
initial_samplesize: 2,062 East Asian ancestry cases, 2,066 East Asian ancestry controls
replication_samplesize: 15,091 East Asian ancestry cases, 14,877 East Asian ancestry controls
region: 7q32.3
chrom: 7
mapped_gene: LINC-PINT
snp_gene_ids: 378805
strongest_risk_snp: rs2048672
strongest_risk_allele: C
snps: rs2048672
snp_id_current: 2048672
context: intron
pvalue_mlog: 5.221848749616356
ci_95: [1.05-1.17]
platform: Affymetrix [684,457]
cnv: N
study:
Genome-wide association study identifies breast cancer risk variant at 10q21.2: results from the Asia Breast Cancer Consortium.


dbdate: 2011-09-30
author: Nakabayashi K
date: 2011-09-08
journal: J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21900946
trait: Graves' disease
initial_samplesize: 1,119 Japanese ancestry cases, 2,718 Japanese ancestry controls
replication_samplesize: 432 Japanese ancestry cases, 1,157 Japanese ancestry controls
region: 6p21.32
chrom: 6
reported_genes: MHC
mapped_gene: C6orf10
snp_gene_ids: 10665
strongest_risk_snp: rs2273017
strongest_risk_allele: A
snps: rs2273017
snp_id_current: 2273017
context: intron
pvalue_mlog: 21.69897000433602
ci_95: [1.40-1.66]
platform: Perlgen [268,068]
cnv: N
study:
Identification of independent risk loci for Graves' disease within the MHC in the Japanese population.


dbdate: 2012-02-10
author: Nicholson G
date: 2011-09-08
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21931564
trait: Metabolite levels
initial_samplesize: 142 European ancestry female twins
replication_samplesize: 202 European ancestry individuals
region: 10q24.2
chrom: 10
reported_genes: PYROXD2, C10orf33
mapped_gene: PYROXD2;MIR1287
snp_gene_ids: 84795;100302133
strongest_risk_snp: rs7072216
strongest_risk_allele: C
snps: rs7072216
snp_id_current: 7072216
context: intron;nearGene-5
pvalue_mlog: 14.09691001300805
ci_95: [0.95-1.43] unit decrease
platform: Illumina [2,541,644] (imputed)
cnv: N
study:
A genome-wide metabolic QTL analysis in Europeans implicates two loci shaped by recent positive selection.


dbdate: 2011-09-30
author: Qi Q
date: 2011-09-06
journal: Eur Heart J
link: http://www.ncbi.nlm.nih.gov/pubmed/21900290
trait: Lp (a) levels
initial_samplesize: 1,450 European ancestry individuals
region: 6q25.3
chrom: 6
reported_genes: SLC22A3
mapped_gene: SLC22A2 - SLC22A3
upstream_gene_id: 6582
downstream_gene_id: 6581
strongest_risk_snp: rs3120139
strongest_risk_allele: A
snps: rs3120139
snp_id_current: 3120139
context: Intergenic
pvalue_mlog: 8.397940008672036
ci_95: [0.22-0.42] mg/dL increase
platform: Illumina [~2.5 million] (imputed)
cnv: N
study:
Genetic variants, plasma lipoprotein(a) levels, and risk of cardiovascular morbidity and mortality among two prospective cohorts of type 2 diabetes.


dbdate: 2011-09-30
author: Amin N
date: 2011-08-30
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/21876539
trait: Coffee consumption
initial_samplesize: 18,176 European ancestry individuals
replication_samplesize: 7,929 European ancestry individuals
region: 15q24.1
chrom: 15
reported_genes: CYP1A1, CYP1A2
mapped_gene: CYP1A1
snp_gene_ids: 1543
strongest_risk_snp: rs2470893
strongest_risk_allele: T
snps: rs2470893
snp_id_current: 2470893
context: nearGene-5
pvalue_mlog: 10.69897000433602
ci_95: [0.05-0.09] unit increase
platform: Affymetrix, Illumina & Perlgen [~2.6 million] (imputed)
cnv: N
study:
Genome-wide association analysis of coffee drinking suggests association with CYP1A1/CYP1A2 and NRCAM.


dbdate: 2011-09-28
author: Sampietro ML
date: 2011-08-30
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21878436
trait: Coronary restenosis
initial_samplesize: 295 European ancestry cases, 571 European ancestry controls
replication_samplesize: 455 European ancestry cases, 2,880 European ancestry controls
region: 12q23.3
chrom: 12
reported_genes: C12orf42, STAB2, NT5DC3
mapped_gene: C12orf42 - STAB2
upstream_gene_id: 374470
downstream_gene_id: 55576
strongest_risk_snp: rs10861032
strongest_risk_allele: C
snps: rs10861032
snp_id_current: 10861032
context: Intergenic
pvalue_mlog: 7
platform: Illumina [556,099]
cnv: N
study:
A genome-wide association study identifies a region at chromosome 12 as a potential susceptibility locus for restenosis after percutaneous coronary intervention.


dbdate: 2011-09-28
author: Kooner JS
date: 2011-08-28
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21874001
trait: Type 2 diabetes
initial_samplesize: 5,561 South Asian ancestry cases, 14,458 South Asian ancestry controls
replication_samplesize: 13,170 South Asian ancestry cases, 25,398 South Asian ancestry controls
region: 2q24.3
chrom: 2
reported_genes: GRB14
mapped_gene: EIF3EP3 - COBLL1
upstream_gene_id: 100462836
downstream_gene_id: 22837
strongest_risk_snp: rs3923113
strongest_risk_allele: A
snps: rs3923113
snp_id_current: 3923113
context: Intergenic
pvalue_mlog: 8
ci_95: [1.06-1.13]
platform: Illumina [568,976]
cnv: N
study:
Genome-wide association study in individuals of South Asian ancestry identifies six new type 2 diabetes susceptibility loci.


dbdate: 2011-09-27
author: Lydall GJ
date: 2011-08-26
journal: Psychiatr Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21876473
trait: Alcohol dependence
initial_samplesize: 506 European ancestry cases, 510 European ancestry controls
region: 16p12.3
chrom: 16
reported_genes: SYT17
mapped_gene: ITPRIPL2 - SYT17
upstream_gene_id: 162073
downstream_gene_id: 51760
strongest_risk_snp: rs8062326
strongest_risk_allele: T
snps: rs8062326
snp_id_current: 8062326
context: Intergenic
pvalue_mlog: 5.397940008672037
platform: Affymetrix [372,193]
cnv: N
study:
Confirmation of prior evidence of genetic susceptibility to alcoholism in a genome-wide association study of comorbid alcoholism and bipolar disorder.


dbdate: 2011-09-27
author: Strawbridge RJ
date: 2011-08-26
journal: Diabetes
link: http://www.ncbi.nlm.nih.gov/pubmed/21873549
trait: Proinsulin levels
initial_samplesize: 10,701 European ancestry individuals
replication_samplesize: 16,378 European ancestry individuals
region: 11q13.4
chrom: 11
reported_genes: ARAP1
mapped_gene: ARAP1
snp_gene_ids: 116985
strongest_risk_snp: rs11603334
strongest_risk_allele: A
snps: rs11603334
snp_id_current: 11603334
context: intron
pvalue_mlog: 101.5228787452803
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Genome-wide association identifies nine common variants associated with fasting proinsulin levels and provides new insights into the pathophysiology of type 2 diabetes.


dbdate: 2011-09-27
author: Ahn MJ
date: 2011-08-25
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21866343
trait: Non-small cell lung cancer
initial_samplesize: 445 Korean ancestry cases, 497 Korean ancestry controls
replication_samplesize: 396 Korean ancestry cases, 998 Korean ancestry controls
region: 18p11.22
chrom: 18
reported_genes: APCDD1, NAPG, FAM38B
mapped_gene: PIEZO2
snp_gene_ids: 63895
strongest_risk_snp: rs11080466
strongest_risk_allele: C
snps: rs11080466
snp_id_current: 11080466
context: intron
pvalue_mlog: 5.999999999999999
ci_95: [1.27-1.72]
platform: Affymetrix [474,503]
cnv: N
study:
The 18p11.22 locus is associated with never smoker non-small cell lung cancer susceptibility in Korean populations.


dbdate: 2011-09-27
author: Irvin MR
date: 2011-08-25
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/21901158
trait: Insulin resistance/response
initial_samplesize: 1,040 African American individuals
region: 15q12
chrom: 15
reported_genes: ATP10A
mapped_gene: LOC100128714
snp_gene_ids: 100128714
strongest_risk_snp: rs6576507
strongest_risk_allele: A
snps: rs6576507
snp_id_current: 6576507
context: intron
pvalue_mlog: 6.397940008672037
ci_95: [8.00-20.00] % increase
platform: Affymetrix [872,243]
cnv: N
study:
Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.


dbdate: 2011-09-22
author: Benyamin B
date: 2011-08-23
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21862451
trait: Butyrylcholinesterase levels
initial_samplesize: 6,879 European ancestry adults
replication_samplesize: 1,260 European ancestry adults, 652 European ancestry adolescents
region: 3q26.1
chrom: 3
reported_genes: BCHE
mapped_gene: BCHE
snp_gene_ids: 590
strongest_risk_snp: rs1803274
strongest_risk_allele: T
snps: rs1803274
snp_id_current: 1803274
context: missense
pvalue_mlog: 261.2218487496164
ci_95: [0.67-0.75] SD decrease
platform: Illumina [2,383,238] (imputed)
cnv: N
study:
GWAS of butyrylcholinesterase activity identifies four novel loci, independent effects within BCHE and secondary associations with metabolic risk factors.


dbdate: 2011-09-23
author: Larsson M
date: 2011-08-12
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21835309
trait: Iris characteristics
initial_samplesize: 2,121 European ancestry individuals
replication_samplesize: 499 European ancestry adolescent twins and siblings, 73 European ancestry adults
region: 2p13.1
chrom: 2
reported_genes: AC007387.1
mapped_gene: LOC102724497
snp_gene_ids: 102724497
strongest_risk_snp: rs205611
strongest_risk_allele: A
snps: rs205611
snp_id_current: 205611
context: intron
pvalue_mlog: 5.999999999999999
ci_95: [0.06-0.18] unit decrease
platform: Illumina [274,604] (imputed)
cnv: N
study:
GWAS findings for human iris patterns: associations with variants in genes that influence normal neuronal pattern development.


dbdate: 2011-09-21
author: Yang TH
date: 2011-08-09
journal: BMC Med Genomics
link: http://www.ncbi.nlm.nih.gov/pubmed/21827660
trait: Glioma
initial_samplesize: 781 European ancestry cases, 3,992 European ancestry controls
region: 5p15.33
chrom: 5
reported_genes: TERT
mapped_gene: TERT
snp_gene_ids: 7015
strongest_risk_snp: rs2736100
snps: rs2736100
snp_id_current: 2736100
context: intron
pvalue_mlog: 8.154901959985743
platform: Illumina [489,781]
cnv: N
study:
Combinations of newly confirmed Glioma-Associated loci link regions on chromosomes 1 and 9 to increased disease risk.


dbdate: 2011-09-17
author: Garcia-Closas M
date: 2011-08-08
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21824976
trait: Bladder cancer
initial_samplesize: 4,501 European ancestry cases, 6,076 European ancestry controls
replication_samplesize: 1,382 European ancestry cases, 2,201 European ancestry controls
region: 18q12.3
chrom: 18
reported_genes: SLC14A1
mapped_gene: SLC14A1
snp_gene_ids: 6563
strongest_risk_snp: rs7238033
snps: rs7238033
snp_id_current: 7238033
context: intron
pvalue_mlog: 8.045757490560675
ci_95: [1.13-1.28]
platform: Illumina [555,912]
cnv: N
study:
A genome-wide association study of bladder cancer identifies a new susceptibility locus within SLC14A1, a urea transporter gene on chromosome 18q12.3.


dbdate: 2011-09-14
author: Liu X
date: 2011-08-03
journal: BMC Med Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21812969
trait: Parkinson's disease
initial_samplesize: 268 Ashkenazi Jewish cases, 178 Ashkenazi Jewish controls
replication_samplesize: 1,782 European ancestry cases, 1,658 European ancestry controls
region: 9p13.3
chrom: 9
reported_genes: UNC13B
mapped_gene: UNC13B
snp_gene_ids: 10497
strongest_risk_snp: rs10121009
strongest_risk_allele: A
snps: rs10121009
snp_id_current: 10121009
context: intron
pvalue_mlog: 5.522878745280337
platform: Illumina [525,124]
cnv: N
study:
Genome-wide association study identifies candidate genes for Parkinson's disease in an Ashkenazi Jewish population.


dbdate: 2011-09-06
author: Chantarangsu S
date: 2011-08-01
journal: Clin Infect Dis
link: http://www.ncbi.nlm.nih.gov/pubmed/21810746
trait: Nevirapine-induced rash
replication_samplesize: 88 Thai ancestry nevirapine-induced rash HIV cases, 145 Thai ancestry nevirapine-tolerant HIV cases
region: 6p21.33
chrom: 6
reported_genes: CCHCR1
mapped_gene: CCHCR1
snp_gene_ids: 54535
strongest_risk_snp: rs1265112
strongest_risk_allele: G
snps: rs1265112
snp_id_current: 1265112
context: intron
pvalue_mlog: 8
ci_95: [2.58-7.36]
platform: Illumina [499,730]
cnv: N
study:
Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash.

initial_samplesize:
72 Thai ancestry nevirapine-induced rash HIV cases, 77 Thai ancestry nevirapine-tolerant rash HIV cases


dbdate: 2011-09-06
author: Mehta NN
date: 2011-08-01
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21846871
trait: Coronary heart disease
initial_samplesize: 8,424 European ancestry cases, 6,996 South Asian cases, 15,062 controls
replication_samplesize: 21,408 cases, 19,185 controls
region: 6p24.1
chrom: 6
reported_genes: PHACTR1
mapped_gene: PHACTR1
snp_gene_ids: 221692
strongest_risk_snp: rs9349379
snps: rs9349379
snp_id_current: 9349379
context: intron
pvalue_mlog: 25.04575749056067
platform: Illumina [~575,00]
cnv: N
study:
A genome-wide association study in europeans and South asians identifies 5 new Loci for coronary artery disease.


dbdate: 2011-08-27
author: Hirota T
date: 2011-07-31
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21804548
trait: Asthma
initial_samplesize: 1,532 Japanese ancestry cases, 3,304 Japanese ancestry controls
replication_samplesize: 5,639 Japanese ancestry cases, 24,608 Japanese ancestry controls
region: 4q31.21
chrom: 4
reported_genes: LOC729675
mapped_gene: LSM3P4 - USP38
upstream_gene_id: 100130178
downstream_gene_id: 84640
strongest_risk_snp: rs7686660
strongest_risk_allele: T
snps: rs7686660
snp_id_current: 7686660
context: Intergenic
pvalue_mlog: 11.69897000433602
ci_95: [1.11-1.21]
platform: Illumina [458,847]
cnv: N
study:
Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population.


dbdate: 2011-08-20
author: Torgerson DG
date: 2011-07-31
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21804549
trait: Asthma
region: 1q23.1
chrom: 1
reported_genes: PYHIN1
mapped_gene: PYHIN1
snp_gene_ids: 149628
strongest_risk_snp: rs1101999
snps: rs1101999
snp_id_current: 1101999
context: intron
pvalue_mlog: 8.397940008672036
platform: Affymetrix & Illumina [>2 million] (imputed)
cnv: N
study:
Meta-analysis of genome-wide association studies of asthma in ethnically diverse North American populations.

initial_samplesize:
2,088 European ancestry cases, 1,612 African American and African Caribbean cases, 1,688 Hispanic cases

replication_samplesize:
2,727 European ancestry cases, 2,147 African American and African Caribbean cases, 2,299 Hispanic cases


dbdate: 2011-09-01
author: Lemaitre RN
date: 2011-07-28
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21829377
trait: Phospholipid levels (plasma)
initial_samplesize: 8,866 European ancestry individuals
region: 11q12.2
chrom: 11
reported_genes: C11orf10
mapped_gene: TMEM258
snp_gene_ids: 746
strongest_risk_snp: rs102275
strongest_risk_allele: T
snps: rs102275
snp_id_current: 102275
context: intron
pvalue_mlog: 63.15490195998574
ci_95: [NR] % dcrease
platform: Affymetrix & Illumina [NR]
cnv: N
study:
Genetic loci associated with plasma phospholipid n-3 fatty acids: a meta-analysis of genome-wide association studies from the CHARGE Consortium.


dbdate: 2011-08-18
author: Traglia M
date: 2011-07-25
journal: J Med Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21785125
trait: Hepcidin levels
initial_samplesize: 1,657 Val Borbera individuals
region: 6p22.2
chrom: 6
reported_genes: HFE
mapped_gene: HFE
snp_gene_ids: 3077
strongest_risk_snp: rs1800562
snps: rs1800562
snp_id_current: 1800562
context: missense
pvalue_mlog: 6.522878745280337
ci_95: [0.24-0.54] ng/ml increase
platform: Illumina [343,866]
cnv: N
study:
Association of HFE and TMPRSS6 genetic variants with iron and erythrocyte parameters is only in part dependent on serum hepcidin concentrations.


dbdate: 2011-08-18
author: Cui B
date: 2011-07-22
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/21799836
trait: Type 2 diabetes
initial_samplesize: 793 Han Chinese ancestry cases, 806 Han Chinese ancestry controls
replication_samplesize: 4,445 Han Chinese ancestry cases, 4,458 Han Chinese ancestry controls
region: 11p15.4
chrom: 11
reported_genes: KCNQ1
mapped_gene: KCNQ1
snp_gene_ids: 3784
strongest_risk_snp: rs163182
strongest_risk_allele: C
snps: rs163182
snp_id_current: 163182
context: intron
pvalue_mlog: 16.69897000433602
ci_95: [NR]
platform: Illumina [474,515]
cnv: N
study:
A genome-wide association study confirms previously reported loci for type 2 diabetes in Han Chinese.


dbdate: 2011-09-02
author: Noguchi E
date: 2011-07-21
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21814517
trait: Asthma
initial_samplesize: 938 Japanese ancestry cases, 2,376 Japanese ancestry controls
replication_samplesize: 1653 East Asian ancestry cases, 1453 East Asian ancestry controls
region: 8q24.11
chrom: 8
reported_genes: SLC30A8
mapped_gene: SLC30A8
snp_gene_ids: 169026
strongest_risk_snp: rs3019885
strongest_risk_allele: G
snps: rs3019885
snp_id_current: 3019885
context: intron
pvalue_mlog: 12.30102999566398
ci_95: [1.24-1.45]
platform: Illumina [450,326]
cnv: N
study:
Genome-wide association study identifies HLA-DP as a susceptibility gene for pediatric asthma in Asian populations.


dbdate: 2011-08-18
author: Chung CM
date: 2011-07-19
journal: Diabetes
link: http://www.ncbi.nlm.nih.gov/pubmed/21771975
trait: Adiponectin levels
initial_samplesize: 382 Han Chinese ancestry young-onset-hypertensive cases
replication_samplesize: 559 Han Chinese ancestry young-onset-hypertensive cases
region: 16q23.3
chrom: 16
reported_genes: CDH13
mapped_gene: CDH13
snp_gene_ids: 1012
strongest_risk_snp: rs4783244
strongest_risk_allele: T
snps: rs4783244
snp_id_current: 4783244
context: intron
pvalue_mlog: 16.22184874961636
ci_95: [0.24-0.46] ug/mL increase
platform: Illumina [509,174]
cnv: N
study:
A genome-wide association study reveals a quantitative trait locus of adiponectin on CDH13 that predicts cardiometabolic outcomes.


dbdate: 2011-08-12
author: Tin A
date: 2011-07-18
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21768215
trait: Urate levels
initial_samplesize: 8,651 African American individuals
replication_samplesize: 1,996 African American individuals
region: 6q23.2
chrom: 6
reported_genes: Intergenic
mapped_gene: LINC01010;LOC101928231
snp_gene_ids: 154092;101928231
strongest_risk_snp: rs9321453
strongest_risk_allele: T
snps: rs9321453
snp_id_current: 9321453
context: intron;intron
pvalue_mlog: 8.999999999999998
ci_95: [NR] mg/dl increase
platform: Affymetrix [NR] (imputed)
cnv: N
study:
Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele.


dbdate: 2011-08-06
author: Png E
date: 2011-07-15
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21764829
trait: Hepatitis B vaccine response
initial_samplesize: 1,683 Indonesian ancestry individuals
replication_samplesize: 1,931 Indonesian ancestry individuals
region: 6p21.32
chrom: 6
reported_genes: HLA-DR
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs3135363
snps: rs3135363
snp_id_current: 3135363
pvalue_mlog: 21.15490195998574
ci_95: [1.35-1.74]
platform: Illumina [455,508]
cnv: N
study:
A genome-wide association study of hepatitis B vaccine response in an Indonesian population reveals multiple independent risk variants in the HLA region.


dbdate: 2011-08-12
author: Debette S
date: 2011-07-14
journal: Circ Res
link: http://www.ncbi.nlm.nih.gov/pubmed/21757650
trait: Vascular endothelial growth factor levels
initial_samplesize: 3,527 European ancestry individuals
replication_samplesize: 1,727 European ancestry individuals
region: 6p21.1
chrom: 6
reported_genes: MGC45491, MRPL14
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs4513773
strongest_risk_allele: G
snps: rs4513773
snp_id_current: 4513773
pvalue_mlog: 584
platform: Affymetrix [2,540,233] (imputed)
cnv: N
study:
Identification of cis- and trans-acting genetic variants explaining up to half the variation in circulating vascular endothelial growth factor levels.


dbdate: 2011-08-12
author: Gorlova O
date: 2011-07-14
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21779181
trait: Systemic sclerosis
initial_samplesize: 2,296 European ancestry cases, 5,172 European ancestry controls
replication_samplesize: 3,175 European ancestry cases, 4,210 European ancestry controls
region: 12p12.1
chrom: 12
reported_genes: SOX5
mapped_gene: SOX5
snp_gene_ids: 6660
strongest_risk_snp: rs11047102
snps: rs11047102
snp_id_current: 11047102
context: intron
pvalue_mlog: 5.301029995663981
ci_95: [1.13-1.35]
platform: Illumina [NR] (imputed)
cnv: N
study:
Identification of novel genetic markers associated with clinical phenotypes of systemic sclerosis through a genome-wide association strategy.


dbdate: 2011-08-12
author: Lovely RS
date: 2011-07-14
journal: Arterioscler Thromb Vasc Biol
link: http://www.ncbi.nlm.nih.gov/pubmed/21757653
trait: Fibrinogen
initial_samplesize: 3,042 individuals
region: 4q31.3
chrom: 4
reported_genes: FGG
mapped_gene: FGG - LRAT
upstream_gene_id: 2266
downstream_gene_id: 9227
strongest_risk_snp: rs7681423
strongest_risk_allele: T
snps: rs7681423
snp_id_current: 7681423
context: Intergenic
pvalue_mlog: 109
ci_95: [0.26-0.32] g/L decrease
platform: Affymetrix [~2.5 million] (imputed)
cnv: N
study:
Assessment of genetic determinants of the association of &#x003b3;' fibrinogen in relation to cardiovascular disease.


dbdate: 2011-08-15
author: Schurks M
date: 2011-07-14
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/21779381
trait: Cardiovascular disease risk factors
initial_samplesize: 5,122 European ancestry female migrain cases
region: 4q22.1
chrom: 4
reported_genes: MEPE
mapped_gene: MEPE
snp_gene_ids: 56955
strongest_risk_snp: rs7698623
snps: rs7698623
snp_id_current: 7698623
context: intron
pvalue_mlog: 6.522878745280337
ci_95: [3.15-12.90]
platform: Illumina [339,596]
cnv: N
study:
Genetic determinants of cardiovascular events among women with migraine: a genome-wide association study.


dbdate: 2011-08-15
author: Winkelmann J
date: 2011-07-14
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21779176
trait: Restless legs syndrome
initial_samplesize: 922 European ancestry cases, 1,526 European ancestry controls
replication_samplesize: 3,935 European ancestry cases, 5,754 European ancestry controls
region: 2p14
chrom: 2
reported_genes: MEIS1
mapped_gene: MEIS1
snp_gene_ids: 4211
strongest_risk_snp: rs2300478
strongest_risk_allele: G
snps: rs2300478
snp_id_current: 2300478
context: intron
pvalue_mlog: 48.52287874528034
ci_95: [1.57-1.81]
platform: Affymetrix [301,406]
cnv: N
study:
Genome-wide association study identifies novel restless legs syndrome susceptibility loci on 2p14 and 16q12.1.


dbdate: 2011-08-05
author: Mbarek H
date: 2011-07-12
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21750111
trait: Hepatitis B
initial_samplesize: 458 Japanese ancestry cases, 2,056 Japanese ancestry controls
replication_samplesize: 2,209 Japanese ancestry cases, 4,440 Japanese ancestry controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DPA1
mapped_gene: HLA-DPA1
snp_gene_ids: 3113
strongest_risk_snp: rs3077
strongest_risk_allele: G
snps: rs3077
snp_id_current: 3077
context: UTR-3
pvalue_mlog: 60.69897000433602
ci_95: [1.73-2.01]
platform: Illumina [423,627]
cnv: N
study:
A genome-wide association study of chronic hepatitis B identified novel risk locus in a Japanese population.


dbdate: 2011-08-05
author: Rafnar T
date: 2011-07-12
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21750109
trait: Bladder cancer
initial_samplesize: 2,234 European ancestry cases, 41,603 European ancestry controls
region: 18q12.3
chrom: 18
reported_genes: SLC14A1
mapped_gene: SLC14A1
snp_gene_ids: 6563
strongest_risk_snp: rs17674580
strongest_risk_allele: T
snps: rs17674580
snp_id_current: 17674580
context: intron
pvalue_mlog: 10.09691001300805
ci_95: [1.11-1.22]
platform: Illumina [5,340,737] (imputed)
cnv: N
study:
European genome-wide association study identifies SLC14A1 as a new urinary bladder cancer susceptibility gene.

replication_samplesize:
3,371 European ancestry cases, 10,261 European ancestry controls, 269 Iranian ancestry cases, 246 Iranian ancestry controls


dbdate: 2011-07-30
author: Evans DM
date: 2011-07-10
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21743469
trait: Ankylosing spondylitis
initial_samplesize: 3,023 European ancestry cases, 8,779 European ancestry controls
replication_samplesize: 2,111 European ancestry cases, 4,483 European ancestry controls
region: 1p31.3
chrom: 1
reported_genes: IL23R
mapped_gene: IL23R
snp_gene_ids: 149233
strongest_risk_snp: rs11209026
strongest_risk_allele: G
snps: rs11209026
snp_id_current: 11209026
context: missense
pvalue_mlog: 16.69897000433602
platform: Illumina [2,223,620] (imputed)
cnv: N
study:
Interaction between ERAP1 and HLA-B27 in ankylosing spondylitis implicates peptide handling in the mechanism for HLA-B27 in disease susceptibility.


dbdate: 2011-08-22
author: Kote-Jarai Z
date: 2011-07-10
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21743467
trait: Prostate cancer
initial_samplesize: 6,621 European ancestry cases, 6,939 European ancestry controls
region: 2p11.2
chrom: 2
reported_genes: GGCX, VAMP8, VAMP5, RNF181
mapped_gene: GGCX - VAMP8
upstream_gene_id: 2677
downstream_gene_id: 8673
strongest_risk_snp: rs10187424
strongest_risk_allele: A
snps: rs10187424
snp_id_current: 10187424
context: Intergenic
pvalue_mlog: 14.52287874528034
ci_95: [1.06-1.12]
platform: NR [2.6 million] (imputed)
cnv: N
study:
Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study.

replication_samplesize:
22,957 European ancestry cases, 23,234 European ancestry controls, 420 East Asian ancestry cases, 433 East Asian ancestry controls, 112 African American cases, 298 African American controls, 7,140 Other ancestry cases, 5,455 Other ancestry controls


dbdate: 2011-08-03
author: Major JM
date: 2011-07-05
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21729881
trait: Vitamin E levels
initial_samplesize: 2,402 European ancestry cases, 1612 European ancestry controls
region: 11q23.3
chrom: 11
reported_genes: BUD13, ZNF259, APOA5
mapped_gene: ZPR1
snp_gene_ids: 8882
strongest_risk_snp: rs964184
strongest_risk_allele: G
snps: rs964184
snp_id_current: 964184
context: intron
pvalue_mlog: 11.09691001300806
ci_95: [0.02-0.06] unit increase
platform: Illumina [NR] (imputed)
cnv: N
study:
Genome-wide association study identifies common variants associated with circulating vitamin E levels.

replication_samplesize:
475 European ancestry cases, 517 European ancestry controls, 1,416 Other ancestry cases, 1,359 Other ancestry controls


dbdate: 2011-08-03
author: Hu Z
date: 2011-07-03
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21725308
trait: Lung cancer
initial_samplesize: 2,331 Han Chinese ancestry cases, 3,077 Han Chinese ancestry controls
replication_samplesize: 6,313 Han Chinese ancestry cases, 6,409 Han Chinese ancestry controls
region: 3q28
chrom: 3
reported_genes: TP63
mapped_gene: TP63
snp_gene_ids: 8626
strongest_risk_snp: rs4488809
strongest_risk_allele: C
snps: rs4488809
snp_id_current: 4488809
context: intron
pvalue_mlog: 25.15490195998574
ci_95: [1.21-1.32]
platform: Affymetrix [906,703]
cnv: N
study:
A genome-wide association study identifies two new lung cancer susceptibility loci at 13q12.12 and 22q12.2 in Han Chinese.


dbdate: 2011-07-29
author: Miki D
date: 2011-07-03
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21725309
trait: Chronic hepatitis C infection
region: 22q12.3
chrom: 22
reported_genes: DEPDC5
mapped_gene: DEPDC5
snp_gene_ids: 9681
strongest_risk_snp: rs1012068
strongest_risk_allele: G
snps: rs1012068
snp_id_current: 1012068
context: intron
pvalue_mlog: 13
ci_95: [1.51-2.03]
platform: Illumina [467,538]
cnv: N
study:
Variation in the DEPDC5 locus is associated with progression to hepatocellular carcinoma in chronic hepatitis C virus carriers.

initial_samplesize:
212 Japanese ancestry chronic hepatitis C with hepatocellular carcinoma cases, 765 Japanese ancestry chronic hepatitis C without hepatocellular carcinoma cases

replication_samplesize:
710 Japanses ancestry chronic hepatitis C with hepatocellular carcinoma cases, 1,625 Japanese ancestry chronic hepatitis C without hepatocellular carcinoma cases


dbdate: 2011-08-06
author: Nyberg F
date: 2011-07-01
journal: Pharmacogenomics
link: http://www.ncbi.nlm.nih.gov/pubmed/21787189
trait: Interstitial lung disease
initial_samplesize: 80 Japanese ancestry cases, 194 Japanese ancestry controls
region: 5q33.1
chrom: 5
reported_genes: Intergenic
mapped_gene: RNA5SP198 - CTB-12O2.1
upstream_gene_id: 100873460
downstream_gene_id: 101927115
strongest_risk_snp: rs170020
strongest_risk_allele: C
snps: rs170020
snp_id_current: 170020
context: Intergenic
pvalue_mlog: 5.397940008672037
ci_95: [1.80-.5.00]
platform: Illumina & Perlgen [465,816]
cnv: N
study:
Interstitial lung disease in gefitinib-treated Japanese patients with non-small-cell lung cancer: genome-wide analysis of genetic data.


dbdate: 2011-07-19
author: Arking DE
date: 2011-06-30
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21738491
trait: Sudden cardiac arrest
initial_samplesize: 1,283 European ancestry cases, ~20,000 European ancestry controls
replication_samplesize: 3,119 European ancestry cases, 11,146 European ancestry controls
region: 2q24.2
chrom: 2
reported_genes: BAZ2B
mapped_gene: BAZ2B
snp_gene_ids: 29994
strongest_risk_snp: rs4665058
strongest_risk_allele: A
snps: rs4665058
snp_id_current: 4665058
context: intron
pvalue_mlog: 9.698970004336017
ci_95: [1.57-2.34]
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Identification of a sudden cardiac death susceptibility locus at 2q24.2 through genome-wide association in European ancestry individuals.


dbdate: 2011-07-21
author: Okada Y
date: 2011-06-30
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21738478
trait: White blood cell types
initial_samplesize: 8,794 Japanese ancestry individuals
replication_samplesize: 5,998 Japanese ancestry individuals
region: 7q21.2
chrom: 7
reported_genes: CDK6
mapped_gene: CDK6
snp_gene_ids: 1021
strongest_risk_snp: rs445
strongest_risk_allele: C
snps: rs445
snp_id_current: 445
context: intron
pvalue_mlog: 9.154901959985741
ci_95: [0.06-0.10] unit increase
platform: Illumina [2,178,645] (imputed)
cnv: N
study:
Identification of nine novel loci associated with white blood cell subtypes in a Japanese population.


dbdate: 2011-07-27
author: Reiner AP
date: 2011-06-30
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21738479
trait: White blood cell count
initial_samplesize: 16,388 African American individuals
region: 7q21.2
chrom: 7
reported_genes: CDK6
mapped_gene: CDK6
snp_gene_ids: 1021
strongest_risk_snp: rs445
strongest_risk_allele: T
snps: rs445
snp_id_current: 445
context: intron
pvalue_mlog: 6.397940008672037
ci_95: [0.02-0.04] liter decrease
platform: Affymetrix & Illumina [2,489,215] (imputed)
cnv: N
study:
Genome-wide association study of white blood cell count in 16,388 African Americans: the continental origins and genetic epidemiology network (COGENT).

replication_samplesize:
3,551 Hispanic individuals, 14,767 Japanese ancestry individuals, 19,509 European ancestry individuals


dbdate: 2011-07-27
author: Smith EN
date: 2011-06-30
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21738484
trait: Bipolar disorder
initial_samplesize: 1,190 European and unknown ancestry cases, 401 European and unknown ancestry controls
replication_samplesize: 16,179 individuals
region: 1p32.1
chrom: 1
reported_genes: NFIA
mapped_gene: PGBD4P8 - NFIA
upstream_gene_id: 100421185
downstream_gene_id: 4774
strongest_risk_snp: rs2989476
strongest_risk_allele: C
snps: rs2989476
snp_id_current: 2989476
context: Intergenic
pvalue_mlog: 5.522878745280337
ci_95: [NR]
platform: Affymetrix [703,019]
cnv: N
study:
Genome-wide association of bipolar disorder suggests an enrichment of replicable associations in regions near genes.


dbdate: 2011-07-20
author: Nebel A
date: 2011-06-29
journal: Mech Ageing Dev
link: http://www.ncbi.nlm.nih.gov/pubmed/21740922
trait: Longevity
initial_samplesize: 763 European ancestry individuals, 1,058 European ancestry individuals
replication_samplesize: 754 European ancestry individuals, 860 European ancestry individuals
region: 19q13.32
chrom: 19
reported_genes: APOC1
mapped_gene: APOC1
snp_gene_ids: 341
strongest_risk_snp: rs4420638
snps: rs4420638
snp_id_current: 4420638
context: nearGene-3
pvalue_mlog: 15.69897000433602
platform: Affymetrix [664,472]
cnv: N
study:
A genome-wide association study confirms APOE as the major gene influencing survival in long-lived individuals.


dbdate: 2011-07-20
author: Teerlink C
date: 2011-06-26
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21706340
trait: Melanoma
initial_samplesize: 156 European ancestry cases from 34 high-risk families, 2,150 European ancestry controls
region: 10q25.1
chrom: 10
mapped_gene: YWHAZP5 - RPL23AP59
upstream_gene_id: 86123
downstream_gene_id: 100271618
strongest_risk_snp: rs17119461
snps: rs17119461
snp_id_current: 17119461
context: Intergenic
pvalue_mlog: 11.15490195998574
ci_95: [4.20-17.0]
platform: Illumina [491,227]
cnv: N
study:
A unique genome-wide association analysis in extended Utah high-risk pedigrees identifies a novel melanoma risk variant on chromosome arm 10q.


dbdate: 2011-07-20
author: Do CB
date: 2011-06-23
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21738487
trait: Parkinson's disease
initial_samplesize: 3,426 European ancestry cases, 29,624 European ancestry controls
region: 12q12
chrom: 12
reported_genes: LRRK2
mapped_gene: LRRK2
snp_gene_ids: 120892
strongest_risk_snp: rs34637584
strongest_risk_allele: A
snps: rs34637584
snp_id_current: 34637584
context: missense
pvalue_mlog: 27.69897000433602
ci_95: [6.43-14.37]
platform: Illumina [522,782]
cnv: N
study:
Web-based genome-wide association study identifies two novel loci and a substantial genetic component for Parkinson's disease.


dbdate: 2011-07-13
author: Nan H
date: 2011-06-23
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21700618
trait: Basal cell carcinoma
initial_samplesize: 2,045 European ancestry cases, 6,013 European ancestry controls
replication_samplesize: 1,426 cases, 4,845 controls
region: 13q32.3
chrom: 13
reported_genes: UBAC2
mapped_gene: HMGB3P4 - CCR12P
upstream_gene_id: 100873890
downstream_gene_id: 100133168
strongest_risk_snp: rs7335046
strongest_risk_allele: G
snps: rs7335046
snp_id_current: 7335046
context: Intergenic
pvalue_mlog: 7.522878745280337
ci_95: [1.18-1.34]
platform: Affymetrix & Illumina [2,318,094] (imputed)
cnv: N
study:
Genome-wide association study identifies novel alleles associated with risk of cutaneous basal cell carcinoma and squamous cell carcinoma.


dbdate: 2011-07-14
author: Wang KS
date: 2011-06-22
journal: J Psychiatr Res
link: http://www.ncbi.nlm.nih.gov/pubmed/21703634
trait: Alcohol dependence
initial_samplesize: 1,283 European ancestry cases, 1,416 European ancestry controls
replication_samplesize: 1,650 European ancestry cases and 1,684 European ancestry controls from 778 nuclear families
region: 1q25.1
chrom: 1
reported_genes: KIAA0040
mapped_gene: TNN - KIAA0040
upstream_gene_id: 63923
downstream_gene_id: 9674
strongest_risk_snp: rs6701037
strongest_risk_allele: C
snps: rs6701037
snp_id_current: 6701037
context: Intergenic
pvalue_mlog: 6.698970004336019
platform: Illumina [up to 818,773]
cnv: N
study:
A meta-analysis of two genome-wide association studies identifies 3 new loci for alcohol dependence.


dbdate: 2011-07-12
author: Okada Y
date: 2011-06-20
journal: Gastroenterology
link: http://www.ncbi.nlm.nih.gov/pubmed/21699788
trait: Inflammatory bowel disease
initial_samplesize: 372 Japanese ancestry Crohn's disease cases, 372 Japanese ancestry ulcerative colitis cases
region: 6p21.32
chrom: 6
reported_genes: MHC
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs9271366
strongest_risk_allele: C
snps: rs9271366
snp_id_current: 9271366
pvalue_mlog: 69.69897000433602
ci_95: [3.74-5.27]
platform: Illumina [461,368]
cnv: N
study:
HLA-Cw*1202-B*5201-DRB1*1502 haplotype increases risk for ulcerative colitis but reduces risk for Crohn's disease.

replication_samplesize:
607 Japanese ancestry Crohn's disease cases, 376 Japanese ancestry ulcerative colitis cases, 905 Japanese ancestry controls


dbdate: 2011-07-14
author: Hoglinger GU
date: 2011-06-19
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21685912
study: Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy.
trait: Progressive supranuclear palsy
replication_samplesize: 1,051 European ancestry cases, 3,560 European ancestry controls
region: 1q25.3
chrom: 1
reported_genes: STX6
mapped_gene: STX6
snp_gene_ids: 10228
strongest_risk_snp: rs1411478
snps: rs1411478
snp_id_current: 1411478
context: intron
pvalue_mlog: 10.39794000867204
ci_95: [1.19-1.37]
platform: Illumina [531,451]
cnv: N
initial_samplesize:
1,069 European ancestry cases, 2,958 European ancestry controls, 45 cases, 329 Other ancestry controls


dbdate: 2011-06-29
author: Eleftherohorinou H
date: 2011-06-13
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21653640
trait: Rheumatoid arthritis
region: 6p21.32
chrom: 6
reported_genes: HLA-DRA
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs9268853
strongest_risk_allele: C
snps: rs9268853
snp_id_current: 9268853
pvalue_mlog: 108.301029995664
ci_95: [2.20-2.60]
platform: Affymetrix & Illumina [NR]
cnv: N
study:
Pathway-driven gene stability selection of two rheumatoid arthritis GWAS identifies and validates new susceptibility genes in receptor mediated signalling pathways.

initial_samplesize:
1,860 European ancestry cases, 2,938 European ancestry controls, 908 Other ancestry cases, 1,260 Other ancestry controls


dbdate: 2011-06-29
author: Sun LD
date: 2011-06-13
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21666691
trait: Atopic dermatitis
initial_samplesize: 1,012 Han Chinese ancestry cases, 1,362 Han Chinese ancestry controls
region: 1q21.3
chrom: 1
reported_genes: FLG
mapped_gene: FLG-AS1
snp_gene_ids: 339400
strongest_risk_snp: rs3126085
strongest_risk_allele: A
snps: rs3126085
snp_id_current: 3126085
context: intron
pvalue_mlog: 11.22184874961635
ci_95: [NR]
platform: Illumina [491,905]
cnv: N
study:
Genome-wide association study identifies two new susceptibility loci for atopic dermatitis in the Chinese Han population.

replication_samplesize:
3,624 Han Chinese ancestry cases, 12,197 Han Chinese ancestry controls, 1,806 European ancestry cases, 3,256 European ancestry controls


dbdate: 2011-06-23
author: Chasman DI
date: 2011-06-12
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21666692
trait: Migraine
initial_samplesize: 5,122 European ancestry cases, 18,108 European ancestry controls
replication_samplesize: 3,831 European ancestry cases, 13,889 European ancestry controls
region: 1p36.32
chrom: 1
reported_genes: PRDM16
mapped_gene: PRDM16
snp_gene_ids: 63976
strongest_risk_snp: rs2651899
strongest_risk_allele: C
snps: rs2651899
snp_id_current: 2651899
context: intron
pvalue_mlog: 8.397940008672036
ci_95: [1.07-1.15]
platform: Illumina and Affymetrix [2,608,509] (imputed)
cnv: N
study:
Genome-wide association study reveals three susceptibility loci for common migraine in the general population.


dbdate: 2011-07-20
author: Aouizerat BE
date: 2011-06-10
journal: BMC Cardiovasc Disord
link: http://www.ncbi.nlm.nih.gov/pubmed/21658281
trait: Sudden cardiac arrest
initial_samplesize: 88 European ancestry cases, 517 European ancestry controls
region: 6p12.3
chrom: 6
reported_genes: Intergenic
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs190759
snps: rs190759
snp_id_current: 190759
pvalue_mlog: 5.301029995663981
ci_95: [1.06-1.16]
platform: Affymetrix [319,222]
cnv: N
study:
GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.


dbdate: 2011-06-29
author: Han S
date: 2011-06-10
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21665993
trait: Corneal curvature
initial_samplesize: 2,008 Chinese ancestry inidividuals, 2,281 Malay ancestry individuals
replication_samplesize: 2,142 Asian Indian ancestry individuals, 929 Chinese ancestry children
region: 1p36.22
chrom: 1
reported_genes: FRAP1
mapped_gene: MTOR
snp_gene_ids: 2475
strongest_risk_snp: rs17036350
strongest_risk_allele: T
snps: rs17036350
snp_id_current: 17036350
context: intron
pvalue_mlog: 12.39794000867204
ci_95: [0.11-0.25] unit increase
platform: Illumina [462,291]
cnv: N
study:
Association of variants in FRAP1 and PDGFRA with corneal curvature in Asian populations from Singapore.


dbdate: 2011-06-29
author: Yu Y
date: 2011-06-10
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21665990
trait: Age-related macular degeneration
initial_samplesize: 2,594 European ancestry cases, 4,134 European ancestry controls
replication_samplesize: 5,640 European ancestry cases, 52,174 European ancestry controls
region: 6q22.1
chrom: 6
reported_genes: FRK, COL10A1
mapped_gene: FRK
snp_gene_ids: 2444
strongest_risk_snp: rs1999930
snps: rs1999930
snp_id_current: 1999930
context: intron
pvalue_mlog: 8
ci_95: [NR]
platform: Affymetrix [6,036,699] (imputed)
cnv: N
study:
Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration.


dbdate: 2011-06-25
author: Tanaka Y
date: 2011-06-09
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21659334
trait: Response to hepatitis C treatment
initial_samplesize: 303 Japanese ancestry cases
replication_samplesize: 391 Japanese ancestry cases
region: 20p13
chrom: 20
reported_genes: DDRGK1
mapped_gene: DDRGK1
snp_gene_ids: 65992
strongest_risk_snp: rs11697186
strongest_risk_allele: T
snps: rs11697186
snp_id_current: 11697186
context: intron
pvalue_mlog: 16.30102999566398
ci_95: [3.10-6.50]
platform: Affymetrix [595,052]
cnv: N
study:
Genome-wide association study identified ITPA/DDRGK1 variants reflecting thrombocytopenia in pegylated interferon and ribavirin therapy for chronic hepatitis C.


dbdate: 2011-06-25
author: Wade R
date: 2011-06-09
journal: Haematologica
link: http://www.ncbi.nlm.nih.gov/pubmed/21659360
trait: Response to antineoplastic agents
initial_samplesize: 356 European ancestary cases
replication_samplesize: 380 European ancestry cases
region: 1q41
chrom: 1
reported_genes: CENPF
mapped_gene: CENPF
snp_gene_ids: 1063
strongest_risk_snp: rs438034
strongest_risk_allele: T
snps: rs438034
snp_id_current: 438034
context: missense
pvalue_mlog: 5.301029995663981
ci_95: [1.44-2.46]
platform: Illumina [326,385]
cnv: N
study:
Association between single nucleotide polymorphism-genotype and outcome of patients with chronic lymphocytic leukemia in a randomized chemotherapy trial.


dbdate: 2011-06-18
author: Below JE
date: 2011-06-07
journal: Diabetologia
link: http://www.ncbi.nlm.nih.gov/pubmed/21647700
trait: Type 2 diabetes
initial_samplesize: 837 Mexican-American cases, 436 Mexican-American controls
replication_samplesize: 967 Mexican ancestry cases, 343 Mexican ancestry controls
region: 9p23
chrom: 9
reported_genes: PTPRD
mapped_gene: PTPRD
snp_gene_ids: 5789
strongest_risk_snp: rs649891
strongest_risk_allele: C
snps: rs649891
snp_id_current: 649891
context: intron
pvalue_mlog: 5.221848749616356
platform: Affymetrix [1,829,586] (imputed)
cnv: N
study:
Genome-wide association and meta-analysis in populations from Starr County, Texas, and Mexico City identify type 2 diabetes susceptibility loci and enrichment for expression quantitative trait loci in top signals.


dbdate: 2011-06-18
author: Wu Y
date: 2011-06-07
journal: Inflammation
link: http://www.ncbi.nlm.nih.gov/pubmed/21647738
trait: C-reactive protein
initial_samplesize: 1,709 Filipino ancestry females
region: 1q23.2
chrom: 1
reported_genes: CRP
mapped_gene: CRPP1
snp_gene_ids: 171422
strongest_risk_snp: rs876537
strongest_risk_allele: C
snps: rs876537
snp_id_current: 876537
pvalue_mlog: 8.999999999999998
ci_95: [0.20-0.38] unit increase
platform: Affymetrix [2,073,674] (imputed)
cnv: N
study:
Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.


dbdate: 2011-06-20
author: Bielinski SJ
date: 2011-06-06
journal: Mayo Clin Proc
link: http://www.ncbi.nlm.nih.gov/pubmed/21646302
trait: Bilirubin levels
initial_samplesize: 6,307 European ancestry individuals
region: 2q37.1
chrom: 2
reported_genes: UGT1A
mapped_gene: UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A1;UGT1A3
snp_gene_ids: 54575;54576;54577;54578;54579;54600;54657;54658;54659
strongest_risk_snp: rs4148325
snps: rs4148325
snp_id_current: 4148325
context: intron;intron;intron;intron;intron;intron;intron;intron;intron
pvalue_mlog: 61.30102999566397
ci_95: [0.15-0.19] mg/dL increase
platform: Illumina [583,129]
cnv: N
study:
Mayo Genome Consortia: a genotype-phenotype resource for genome-wide association studies with an application to the analysis of circulating bilirubin levels.


dbdate: 2011-06-16
author: Wu C
date: 2011-06-05
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21642993
trait: Esophageal cancer
initial_samplesize: 2,031 Han Chinese ancestry cases, 2,044 Han Chinese ancestry controls
replication_samplesize: 3,986 Han Chinese ancestry cases, 4,157 Han Chinese ancestry controls
region: 12q24.13
chrom: 12
reported_genes: RPL6
mapped_gene: HECTD4
snp_gene_ids: 283450
strongest_risk_snp: rs11066280
strongest_risk_allele: A
snps: rs11066280
snp_id_current: 11066280
context: intron
pvalue_mlog: 14.69897000433602
ci_95: [1.22-1.38]
platform: Affymetrix [666,141]
cnv: N
study:
Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.


dbdate: 2011-06-23
author: Antunez C
date: 2011-05-31
journal: Genome Med
link: http://www.ncbi.nlm.nih.gov/pubmed/21627779
trait: Alzheimer's disease
initial_samplesize: 319 European ancestry cases, 769 European ancestry controls, 2,690 cases, 2,237 controls
region: 11q12.2
chrom: 11
reported_genes: MS4A
mapped_gene: MIR6503 - MS4A4A
upstream_gene_id: 102465250
downstream_gene_id: 51338
strongest_risk_snp: rs1562990
snps: rs1562990
snp_id_current: 1562990
context: Intergenic
pvalue_mlog: 10.39794000867204
ci_95: [1.10-1.18]
platform: Affymetrix and Illumina [696,707](imputed)
cnv: N
study:
The membrane-spanning 4-domains, subfamily A (MS4A) gene cluster contains a common variant associated with Alzheimer's disease.

replication_samplesize:
4,982 European ancestry cases, 7,961 European ancestry controls, 2,190 Other ancestry cases, 3,374 Other ancestry controls


dbdate: 2011-06-14
author: Aragam N
date: 2011-05-26
journal: J Affect Disord
link: http://www.ncbi.nlm.nih.gov/pubmed/21621269
trait: Major depressive disorder
initial_samplesize: 1,726 Other ancestry cases, 1,630 Other ancestry controls
region: 7p14.3
chrom: 7
reported_genes: ADCYAP1R1
mapped_gene: ADCYAP1R1 - NEUROD6
upstream_gene_id: 117
downstream_gene_id: 63974
strongest_risk_snp: rs1558477
snps: rs1558477
snp_id_current: 1558477
context: Intergenic
pvalue_mlog: 6.522878745280337
platform: Perlegen [433,556]
cnv: N
study:
Genome-wide association analysis of gender differences in major depressive disorder in the Netherlands NESDA and NTR population-based samples.


dbdate: 2011-06-14
author: Malovini A
date: 2011-05-25
journal: Rejuvenation Res
link: http://www.ncbi.nlm.nih.gov/pubmed/21612516
trait: Longevity
initial_samplesize: 410 European ancestry long-living individuals, 553 European ancestry young individuals
replication_samplesize: 116 European ancestry long-living individuals, 160 European ancestry young individuals
region: 5q22.1
chrom: 5
reported_genes: CAMKIV
mapped_gene: CAMK4
snp_gene_ids: 814
strongest_risk_snp: rs10491334
strongest_risk_allele: C
snps: rs10491334
snp_id_current: 10491334
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [1.43-2.33]
platform: Illumina [298,715]
cnv: N
study:
Association study on long-living individuals from Southern Italy identifies rs10491334 in the CAMKIV gene that regulates survival proteins.


dbdate: 2011-06-04
author: Wild PS
date: 2011-05-23
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21606135
trait: Coronary heart disease
initial_samplesize: 2,078 European ancestry cases, 2,953 European ancestry controls
replication_samplesize: 19,350 European ancestry cases, 35,408 European ancestry controls
region: 9p21.3
chrom: 9
reported_genes: Intergenic
mapped_gene: UBA52P6 - DMRTA1
upstream_gene_id: 100130239
downstream_gene_id: 63951
strongest_risk_snp: rs1333049
strongest_risk_allele: C
snps: rs1333049
snp_id_current: 1333049
context: Intergenic
pvalue_mlog: 57.15490195998574
ci_95: [1.23-1.31]
platform: Affymetrix [608,247]
cnv: N
study:
A genome-wide association study identifies LIPA as a susceptibility gene for coronary artery disease.


dbdate: 2011-06-03
author: Haiman CA
date: 2011-05-22
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21602798
trait: Prostate cancer
initial_samplesize: 3,425 African American cases, 3,290 African American controls
region: 17q21.33
chrom: 17
reported_genes: ZNF652
mapped_gene: ZNF652;LOC102724596
snp_gene_ids: 22834;102724596
strongest_risk_snp: rs7210100
snps: rs7210100
snp_id_current: 7210100
context: intron;nearGene-5
pvalue_mlog: 12.52287874528034
ci_95: [1.35-1.69]
platform: Illumina [1,047,1986]
cnv: N
study:
Genome-wide association study of prostate cancer in men of African ancestry identifies a susceptibility locus at 17q21.

replication_samplesize:
1,500 African American/Afro-Caribbean cases, 1,908 African American/Afro-Caribbean controls, 344 Sub-Saharan African ancestry cases, 1,361 Sub-Saharan African ancestry controls


dbdate: 2011-06-07
author: Wright FA
date: 2011-05-22
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21602797
trait: Cystic fibrosis severity
initial_samplesize: 2,317 European ancestry cases, 177 cases
replication_samplesize: 898 European ancestry sibling pair cases, 75 sibling pair cases
region: 11p13
chrom: 11
reported_genes: APIP, EHF
mapped_gene: NDUFB8P3 - APIP
upstream_gene_id: 100132286
downstream_gene_id: 51074
strongest_risk_snp: rs12793173
strongest_risk_allele: C
snps: rs12793173
snp_id_current: 12793173
context: Intergenic
pvalue_mlog: 8.999999999999998
platform: Illumina [~2,609,000] (imputed)
cnv: N
study:
Genome-wide association and linkage identify modifier loci of lung disease severity in cystic fibrosis at 11p13 and 20q13.2.


dbdate: 2011-07-30
author: Thompson AJ
date: 2011-05-20
journal: J Hepatol
link: http://www.ncbi.nlm.nih.gov/pubmed/21703177
study: Genome-wide association study of interferon-related cytopenia in chronic hepatitis C patients.
trait: IFN-related cytopenia
region: 20p13
chrom: 20
reported_genes: ITPA
mapped_gene: C20orf194
snp_gene_ids: 25943
strongest_risk_snp: rs965469
snps: rs965469
snp_id_current: 965469
context: intron
pvalue_mlog: 8.999999999999998
platform: Illumina [565,759]
cnv: N
initial_samplesize:
984 European ancestry with genotype 1 HCV cases, 201 African American genotype 1 HCV cases, 99 Hispanic genotype 1 HCV cases


dbdate: 2011-07-13
author: Kato N
date: 2011-05-15
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21572416
trait: Blood pressure
initial_samplesize: 19,608 East Asian ancestry individuals
replication_samplesize: 30,765 East Asian ancestry individuals
region: 1p13.2
chrom: 1
reported_genes: ST7L, CAPZA1
mapped_gene: CAPZA1
snp_gene_ids: 829
strongest_risk_snp: rs17030613
strongest_risk_allele: C
snps: rs17030613
snp_id_current: 17030613
context: intron
pvalue_mlog: 5.096910013008055
ci_95: [0.27-0.71] mm Hg increase
platform: Affymetrix & Illumina [1.7 million] (imputed)
cnv: N
study:
Meta-analysis of genome-wide association studies identifies common variants associated with blood pressure variation in east Asians.


dbdate: 2011-06-03
author: Parra EJ
date: 2011-05-15
journal: Diabetologia
link: http://www.ncbi.nlm.nih.gov/pubmed/21573907
trait: Type 2 diabetes
initial_samplesize: 1,804 Hispanic cases, 780 Hispanic controls
replication_samplesize: (NR) European ancestry individuals
region: 3q27.2
chrom: 3
reported_genes: IGF2BP2
mapped_gene: IGF2BP2
snp_gene_ids: 10644
strongest_risk_snp: rs1374910
strongest_risk_allele: T
snps: rs1374910
snp_id_current: 1374910
context: intron
pvalue_mlog: 7
ci_95: [1.15-1.34]
platform: Affymetrix [315,658]
cnv: N
study:
Genome-wide association study of type 2 diabetes in a sample from Mexico City and a meta-analysis of a Mexican-American sample from Starr County, Texas.


dbdate: 2011-06-01
author: Teumer A
date: 2011-05-13
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21565293
trait: Thyroid volume
initial_samplesize: 3,620 European ancestry individuals
replication_samplesize: 1,290 European ancestry individuals
region: 1p36.13
chrom: 1
reported_genes: CAPZB
mapped_gene: CAPZB - MINOS1
upstream_gene_id: 832
downstream_gene_id: 440574
strongest_risk_snp: rs12138950
strongest_risk_allele: A
snps: rs12138950
snp_id_current: 12138950
context: Intergenic
pvalue_mlog: 17.52287874528034
ci_95: [0.08-0.12] unit decrease
platform: Affymetrix [2,748,910] (imputed)
cnv: N
study:
Genome-wide association study identifies four genetic loci associated with thyroid volume and goiter risk.


dbdate: 2011-05-27
author: Kanetsky PA
date: 2011-05-06
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21551455
trait: Testicular cancer
initial_samplesize: 349 European ancestry cases, 919 European ancestry controls
replication_samplesize: 439 European ancestry cases,960 European ancestry controls
region: 9p24.3
chrom: 9
reported_genes: DMRT1
mapped_gene: DMRT1
snp_gene_ids: 1761
strongest_risk_snp: rs7040024
strongest_risk_allele: A
snps: rs7040024
snp_id_current: 7040024
context: intron
pvalue_mlog: 11
ci_95: [1.46-1.99]
platform: Affymetrix [609,482]
cnv: N
study:
A second independent locus within DMRT1 is associated with testicular germ cell tumor susceptibility.


dbdate: 2011-06-01
author: Guerrero JA
date: 2011-05-03
journal: Haematologica
link: http://www.ncbi.nlm.nih.gov/pubmed/21546496
trait: Platelet function and related traits
initial_samplesize: 70 children
replication_samplesize: 286 children
region: 5q35.3
chrom: 5
reported_genes: F12
mapped_gene: F12 - GRK6
upstream_gene_id: 2161
downstream_gene_id: 2870
strongest_risk_snp: rs2731672
snps: rs2731672
snp_id_current: 2731672
context: Intergenic
pvalue_mlog: 5.999999999999999
platform: Illumina [320,610]
cnv: N
study:
Novel loci involved in platelet function and platelet count identified by a genome-wide study performed in children.


dbdate: 2011-06-01
author: Kim DH
date: 2011-05-03
journal: Blood
link: http://www.ncbi.nlm.nih.gov/pubmed/21540461
trait: Chronic myeloid leukemia
initial_samplesize: 201 Korean ancestry cases, 497 Korean ancestry controls
region: 6q25.1
chrom: 6
reported_genes: MTHFD1L, AKAP12, ZBTB2, RMND1, C6orf211, C6orf97, ESR1
mapped_gene: CCDC170
snp_gene_ids: 80129
strongest_risk_snp: rs4869742
strongest_risk_allele: T
snps: rs4869742
snp_id_current: 4869742
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [1.35-2.04]
platform: Affymetrix [456,522]
cnv: N
study:
A genome-wide association study identifies novel loci associated with susceptibility to chronic myeloid leukemia.

replication_samplesize:
237 Korean ancestry cases, 1,000 Korean ancestry controls, 232 European ancestry cases, 576 European ancestry controls


dbdate: 2011-06-01
author: Burdon KP
date: 2011-05-01
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21532571
trait: Glaucoma
initial_samplesize: 590 European ancestry cases, 3,956 European ancestry controls
replication_samplesize: 892 European ancestry advanced cases, 4,582 European ancestry less severe cases
region: 1q24.1
chrom: 1
reported_genes: TMCO1
mapped_gene: RPL21P27 - TMCO1
upstream_gene_id: 100270952
downstream_gene_id: 54499
strongest_risk_snp: rs4656461
strongest_risk_allele: G
snps: rs4656461
snp_id_current: 4656461
context: Intergenic
pvalue_mlog: 13.22184874961636
ci_95: [1.35-1.68]
platform: Illumina [298,778]
cnv: N
study:
Genome-wide association study identifies susceptibility loci for open angle glaucoma at TMCO1 and CDKN2B-AS1.


dbdate: 2011-06-01
author: Ramsuran V
date: 2011-05-01
journal: Clin Infect Dis
link: http://www.ncbi.nlm.nih.gov/pubmed/21507922
trait: Neutrophil count
initial_samplesize: 115 African ancestry HIV-negative individuals
region: 1q23.2
chrom: 1
reported_genes: DARC
mapped_gene: ACKR1
snp_gene_ids: 2532
strongest_risk_snp: rs2814778
snps: rs2814778
snp_id_current: 2814778
context: UTR-5
pvalue_mlog: 8
platform: Illumina [874,956]
cnv: N
study:
Duffy-null-associated low neutrophil counts influence HIV-1 susceptibility in high-risk South African black women.


dbdate: 2011-05-28
author: Heath AC
date: 2011-04-27
journal: Biol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/21529783
trait: Alcoholism (12-month weekly alcohol consumption)
initial_samplesize: 2,062 European ancestry alcohol dependence cases, 6,692 European ancestry controls
replication_samplesize: 3,393 European ancestry individuals
region: 7q11.23
chrom: 7
reported_genes: HIP1
mapped_gene: HIP1
snp_gene_ids: 3092
strongest_risk_snp: rs237238
strongest_risk_allele: A
snps: rs237238
snp_id_current: 237238
context: cds-synon
pvalue_mlog: 5.154901959985742
ci_95: [NR] unit increase
platform: Illumina [~300,000]
cnv: N
study:
A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications.


dbdate: 2011-05-27
author: Duncan EL
date: 2011-04-21
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21533022
trait: Bone mineral density
replication_samplesize: 20,898 European ancestry females
region: 2q24.3
chrom: 2
reported_genes: GALNT3
mapped_gene: CSRNP3 - GALNT3
upstream_gene_id: 80034
downstream_gene_id: 2591
strongest_risk_snp: rs6710518
strongest_risk_allele: T
snps: rs6710518
snp_id_current: 6710518
context: Intergenic
pvalue_mlog: 9.301029995663981
ci_95: [NR] unit decrease
platform: Illumina [2,543,887] (imputed)
cnv: N
study:
Genome-wide association study using extreme truncate selection identifies novel genes affecting bone mineral density and fracture risk.

initial_samplesize:
900 European ancestry females with low hip bone mineral density, 1,055 European ancestry females with high hip bone mineral density


dbdate: 2011-05-27
author: Pare G
date: 2011-04-21
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21533024
trait: Soluble ICAM-1
initial_samplesize: 22,435 European ancestry females
replication_samplesize: 9,813 Other ancestry individuals
region: 9q34.2
chrom: 9
reported_genes: ABO
mapped_gene: ABO
snp_gene_ids: 28
strongest_risk_snp: rs507666
strongest_risk_allele: A
snps: rs507666
snp_id_current: 507666
context: intron
pvalue_mlog: 90.52287874528034
ci_95: [NR] ng/mL decrease
platform: Illumina [334,295]
cnv: N
study:
Genome-wide association analysis of soluble ICAM-1 concentration reveals novel associations at the NFKBIK, PNPLA3, RELA, and SH2B3 loci.


dbdate: 2011-05-25
author: Smedby KE
date: 2011-04-21
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21533074
trait: Follicular lymphoma
initial_samplesize: 379 European ancestry cases, 791 European ancestry controls
replication_samplesize: 1,049 European ancestry cases, 3,952 European ancestry controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DQB1
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs2647012
strongest_risk_allele: G
snps: rs2647012
snp_id_current: 2647012
pvalue_mlog: 20.69897000433602
ci_95: [1.43-1.72]
platform: Illumina [298,168]
cnv: N
study:
GWAS of follicular lymphoma reveals allelic heterogeneity at 6p21.32 and suggests shared genetic susceptibility with diffuse large B-cell lymphoma.


dbdate: 2011-05-26
author: Dorajoo R
date: 2011-04-19
journal: Int J Obes (Lond)
link: http://www.ncbi.nlm.nih.gov/pubmed/21544081
study: Replication of 13 obesity loci among Singaporean Chinese, Malay and Asian-Indian populations.
trait: Obesity
region: 16q12.2
chrom: 16
reported_genes: FTO
mapped_gene: FTO
snp_gene_ids: 79068
strongest_risk_snp: rs1558902
strongest_risk_allele: T
snps: rs1558902
snp_id_current: 1558902
context: intron
pvalue_mlog: 7
ci_95: [0.06-0.12] unit decrease
platform: Illumina [1,283,957] (imputed)
cnv: N
initial_samplesize:
5,429 Chinese anacestry individuals, 2,431 Malay ancestry individuals, 2,531 Asian Indian ancestry individuals


dbdate: 2011-05-13
author: Li Z
date: 2011-04-19
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21505071
trait: Myopia (pathological)
initial_samplesize: 102 Han Chinese ancestry cases, 335 Han Chinese ancestry controls
replication_samplesize: 2,891 Han Chinese ancestry cases, 10,071 Han Chinese ancestry controls
region: 4q25
chrom: 4
reported_genes: MYP11
mapped_gene: RPL36AP23 - CCDC34P1
upstream_gene_id: 729075
downstream_gene_id: 100288584
strongest_risk_snp: rs10034228
snps: rs10034228
snp_id_current: 10034228
context: Intergenic
pvalue_mlog: 12.09691001300806
ci_95: [1.16-1.32]
platform: Affymetrix [681,783]
cnv: N
study:
A genome-wide association study reveals association between common variants in an intergenic region of 4q25 and high-grade myopia in the Chinese Han population.


dbdate: 2011-05-26
author: Stein JL
date: 2011-04-19
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/21502949
trait: Caudate nucleus volume
initial_samplesize: 734 European ancestry individuals
replication_samplesize: 464 European ancestry individuals
region: 6p25.3
chrom: 6
reported_genes: GMDS
mapped_gene: GMDS
snp_gene_ids: 2762
strongest_risk_snp: rs9378688
strongest_risk_allele: A
snps: rs9378688
snp_id_current: 9378688
context: intron
pvalue_mlog: 5.221848749616356
ci_95: [87.56-220.84] mm3 decrease
platform: Illumina [520,459]
cnv: N
study:
Discovery and replication of dopamine-related gene effects on caudate volume in young and elderly populations (N=1198) using genome-wide search.


dbdate: 2011-05-25
author: Terao C
date: 2011-04-19
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21505073
trait: Rheumatoid arthritis
initial_samplesize: 1,247 Japanese ancestry cases, 1,486 Japanese ancestry controls
replication_samplesize: 4,168 Japanese ancestry cases, 5,003 Japanese ancestry controls
region: 21q22.3
chrom: 21
reported_genes: AIRE, PFKL
mapped_gene: AIRE
snp_gene_ids: 326
strongest_risk_snp: rs2075876
strongest_risk_allele: A
snps: rs2075876
snp_id_current: 2075876
context: intron
pvalue_mlog: 8.397940008672036
ci_95: [1.11-1.24]
platform: Illumina [241,523]
cnv: N
study:
The human AIRE gene at chromosome 21q22 is a genetic determinant for the predisposition to rheumatoid arthritis in Japanese population.


dbdate: 2011-05-25
author: Weber F
date: 2011-04-19
journal: Pharmacogenomics J
link: http://www.ncbi.nlm.nih.gov/pubmed/21502966
trait: Response to interferon beta therapy
region: 6p21.32
chrom: 6
reported_genes: HLA-DQA1, HLA-DRB1
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs9272105
strongest_risk_allele: A
snps: rs9272105
snp_id_current: 9272105
pvalue_mlog: 9.397940008672037
ci_95: [NR] unit increase
platform: Illumina [~317,000]
cnv: N
study:
Single-nucleotide polymorphisms in HLA- and non-HLA genes associated with the development of antibodies to interferon-&#x003b2; therapy in multiple sclerosis patients.

initial_samplesize:
178 European ancestry antibody-positive individuals, 184 European ancestry antibody-negative individuals

replication_samplesize:
350 European ancestry antibody-positive individuals, 468 European ancestry antibody-negative individuals


dbdate: 2011-05-11
author: Kumar V
date: 2011-04-17
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21499248
trait: Hepatocellular carcinoma
initial_samplesize: 721 Japanese ancestry cases, 2,890 Japanese ancestry controls
replication_samplesize: 673 Japanese ancestry cases, 2,596 Japanese ancestry controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DQ, HLA-DR
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs9275572
strongest_risk_allele: A
snps: rs9275572
snp_id_current: 9275572
pvalue_mlog: 8.221848749616356
ci_95: [1.19-1.42]
platform: Illumina [432,703]
cnv: N
study:
Genome-wide association study identifies a susceptibility locus for HCV-induced hepatocellular carcinoma.


dbdate: 2011-05-24
author: Spurdle AB
date: 2011-04-17
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21499250
trait: Endometrial cancer
initial_samplesize: 1,265 European ancestry cases, 5,190 European ancestry controls
replication_samplesize: 3,957 European ancestry cases, 6,886 European ancestry controls
region: 17q12
chrom: 17
reported_genes: HNF1B
mapped_gene: HNF1B
snp_gene_ids: 6928
strongest_risk_snp: rs4430796
strongest_risk_allele: A
snps: rs4430796
snp_id_current: 4430796
context: intron
pvalue_mlog: 9.154901959985741
ci_95: [1.12-1.27]
platform: Illumina [519,655]
cnv: N
study:
Genome-wide association study identifies a common variant associated with risk of endometrial cancer.


dbdate: 2011-05-26
author: Zhai G
date: 2011-04-14
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21533175
trait: Dehydroepiandrosterone sulphate levels
initial_samplesize: 14,846 European ancestry individuals
region: 7q22.1
chrom: 7
reported_genes: ZKSCAN5
mapped_gene: ZKSCAN5
snp_gene_ids: 23660
strongest_risk_snp: rs11761528
strongest_risk_allele: T
snps: rs11761528
snp_id_current: 11761528
context: intron
pvalue_mlog: 35.52287874528034
ci_95: [0.14-0.18] umol/L decrease
platform: Affymetrix & Illumina [~2.5 million](imputed)
cnv: N
study:
Eight common genetic variants associated with serum DHEAS levels suggest a key role in ageing mechanisms.


dbdate: 2011-05-27
author: Lucena MI
date: 2011-04-12
journal: Gastroenterology
link: http://www.ncbi.nlm.nih.gov/pubmed/21570397
trait: Drug-induced liver injury (amoxicillin-clavulanate)
initial_samplesize: 201 European ancestry cases, 532 European ancestry controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DRB1-DQB1
mapped_gene: HLA-DQB1
snp_gene_ids: 3119
strongest_risk_snp: rs9274407
snps: rs9274407
snp_id_current: 9274407
context: missense
pvalue_mlog: 13.30102999566398
ci_95: [2.30-4.20]
platform: Illumina [822,927]
cnv: N
study:
Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles.


dbdate: 2011-05-11
author: Wu X
date: 2011-04-11
journal: J Natl Cancer Inst
link: http://www.ncbi.nlm.nih.gov/pubmed/21483023
trait: Response to platinum-based chemotherapy in non-small-cell lung cancer
initial_samplesize: 327 European ancestry individuals
replication_samplesize: 735 European ancestry individuals
region: 12q23.3
chrom: 12
reported_genes: CMKLR1
mapped_gene: CMKLR1
snp_gene_ids: 1240
strongest_risk_snp: rs1878022
snps: rs1878022
snp_id_current: 1878022
context: intron
pvalue_mlog: 6.30102999566398
ci_95: [1.19-1.48]
platform: Illumina [307,260]
cnv: N
study:
Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy.


dbdate: 2011-05-11
author: Nan H
date: 2011-04-09
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21478494
trait: Cutaneous nevi
initial_samplesize: 9,136 European ancestry individuals
replication_samplesize: 3,581 European ancestry individuals
region: 1q42.3
chrom: 1
reported_genes: NID1
mapped_gene: NID1
snp_gene_ids: 4811
strongest_risk_snp: rs3768080
strongest_risk_allele: A
snps: rs3768080
snp_id_current: 3768080
context: intron
pvalue_mlog: 7.154901959985742
ci_95: [0.05-0.09] unit decrease
platform: Affymetrix and Illumina [2,318,094] (imputed)
cnv: N
study:
Genome-wide association study identifies nidogen 1 (NID1) as a susceptibility locus to cutaneous nevi and melanoma risk.


dbdate: 2011-05-26
author: Cornelis MC
date: 2011-04-07
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21490707
trait: Caffeine consumption
initial_samplesize: 47,431 European ancestry individuals
region: 7p21.1
chrom: 7
reported_genes: AHR
mapped_gene: RAD17P1 - AHR
upstream_gene_id: 9207
downstream_gene_id: 196
strongest_risk_snp: rs4410790
strongest_risk_allele: T
snps: rs4410790
snp_id_current: 4410790
context: Intergenic
pvalue_mlog: 18.69897000433602
ci_95: [0.11-0.19] mg/day decrease
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.


dbdate: 2011-05-11
author: Fliers EA
date: 2011-04-07
journal: World J Biol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/21473668
trait: Attention deficit hyperactivity disorder motor coordination
initial_samplesize: 890 European ancestry children
replication_samplesize: 296 European ancestry children
region: 4p15.1
chrom: 4
reported_genes: Intergenic
mapped_gene: EEF1A1P21 - RPS3AP17
upstream_gene_id: 100421807
downstream_gene_id: 100271130
strongest_risk_snp: rs7442317
snps: rs7442317
snp_id_current: 7442317
context: Intergenic
pvalue_mlog: 5.397940008672037
platform: Perlegen [384,401]
cnv: N
study:
Genome-wide association study of motor coordination problems in ADHD identifies genes for brain and muscle function.


dbdate: 2011-05-24
author: Sim X
date: 2011-04-07
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21490949
study: Transferability of type 2 diabetes implicated loci in multi-ethnic cohorts from Southeast Asia.
trait: Type 2 diabetes
region: 15q24.3
chrom: 15
reported_genes: HMG20A
mapped_gene: HMG20A
snp_gene_ids: 10363
strongest_risk_snp: rs7119
strongest_risk_allele: T
snps: rs7119
snp_id_current: 7119
context: UTR-3
pvalue_mlog: 6.30102999566398
ci_95: [1.14-1.34]
platform: Illumina [~2,000,000] (imputed)
cnv: N
initial_samplesize:
2,010 Chinese ancestry cases, 1,945 Chinese ancestry controls, 794 Malay ancestry cases, 1,240 Malay ancestry controls, 977 Asian Indian ancestry cases, 1,169 Asian Indian ancestry controls


dbdate: 2011-05-24
author: Schumann G
date: 2011-04-06
journal: Proc Natl Acad Sci U S A
link: http://www.ncbi.nlm.nih.gov/pubmed/21471458
trait: Alcohol consumption
initial_samplesize: 26,316 European ancestry individuals
replication_samplesize: 21,185 European ancestry individuals
region: 7q11.22
chrom: 7
reported_genes: AUTS2
mapped_gene: AUTS2
snp_gene_ids: 26053
strongest_risk_snp: rs6943555
strongest_risk_allele: A
snps: rs6943555
snp_id_current: 6943555
context: intron
pvalue_mlog: 7.397940008672037
ci_95: [-0.003-0.028] unit decrease
platform: Affymetrix, Illumina, and Perlegen [~2.5 million] (imputed)
cnv: N
study:
Genome-wide association and genetic functional studies identify autism susceptibility candidate 2 gene (AUTS2) in the regulation of alcohol consumption.


dbdate: 2011-05-02
author: Cha PC
date: 2011-04-03
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21460842
trait: Uterine fibroids
initial_samplesize: 1,607 Japanese ancestry cases, 1,428 Japanese ancestry controls
replication_samplesize: 3,439 Japanese ancestry cases, 3,244 Japanese ancestry controls
region: 10q24.33
chrom: 10
reported_genes: SLK, OBFC1
mapped_gene: LOC102724351
snp_gene_ids: 102724351
strongest_risk_snp: rs7913069
strongest_risk_allele: A
snps: rs7913069
snp_id_current: 7913069
context: intron
pvalue_mlog: 13.04575749056067
ci_95: [1.23-1.75]
platform: Illumina [457,044]
cnv: N
study:
A genome-wide association study identifies three loci associated with susceptibility to uterine fibroids.


dbdate: 2011-05-02
author: Hollingworth P
date: 2011-04-03
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21460840
trait: Alzheimer's disease
initial_samplesize: 6,688 European ancestry cases, 13,685 European ancestry controls
replication_samplesize: 13,182 European ancestry cases, 26,161 European ancestry controls
region: 19p13.3
chrom: 19
reported_genes: ABCA7
mapped_gene: ABCA7
snp_gene_ids: 10347
strongest_risk_snp: rs3764650
snps: rs3764650
snp_id_current: 3764650
context: intron
pvalue_mlog: 16.30102999566398
ci_95: [1.18-1.30]
platform: Affymetrix & Illumina [496,763]
cnv: N
study:
Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease.


dbdate: 2011-05-24
author: Naj AC
date: 2011-04-03
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21460841
trait: Alzheimer's disease (late onset)
initial_samplesize: 8,309 European ancestry cases, 7,366 European ancestry controls
replication_samplesize: 10,523 European ancestry cases, 28,231 European ancestry controls
region: 6p12.3
chrom: 6
reported_genes: CD2AP
mapped_gene: CD2AP
snp_gene_ids: 23607
strongest_risk_snp: rs9349407
strongest_risk_allele: C
snps: rs9349407
snp_id_current: 9349407
context: intron
pvalue_mlog: 8.045757490560675
ci_95: [1.07-1.15]
platform: Affymetrix & Illumina [2,324,889] (imputed)
cnv: N
study:
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.


dbdate: 2011-04-29
author: Gu J
date: 2011-04-02
journal: Cancer Prev Res (Phila)
link: http://www.ncbi.nlm.nih.gov/pubmed/21460395
trait: Telomere length
initial_samplesize: 459 Other ancestry individuals
replication_samplesize: 1,160 Other ancestry individuals
region: 20q12
chrom: 20
reported_genes: DHX35
mapped_gene: ATG3P1 - HSPE1P1
upstream_gene_id: 100135756
downstream_gene_id: 140895
strongest_risk_snp: rs6028466
snps: rs6028466
snp_id_current: 6028466
context: Intergenic
pvalue_mlog: 6.522878745280337
ci_95: [NR] unit increase
platform: Illumina [312,531]
cnv: N
study:
A genome-wide association study identifies a locus on chromosome 14q21 as a predictor of leukocyte telomere length and as a marker of susceptibility for bladder cancer.


dbdate: 2011-04-29
author: Freudenberg J
date: 2011-04-01
journal: Arthritis Rheum
link: http://www.ncbi.nlm.nih.gov/pubmed/21452313
trait: Rheumatoid arthritis
initial_samplesize: 801 Korean ancestry cases, 757 Korean ancestry controls
replication_samplesize: 718 Korean ancestry cases, 719 Korean ancestry controls
region: 8p23.1
chrom: 8
reported_genes: BLK
mapped_gene: BLK
snp_gene_ids: 640
strongest_risk_snp: rs1600249
snps: rs1600249
snp_id_current: 1600249
context: intron
pvalue_mlog: 5.301029995663981
ci_95: [1.16-1.45]
platform: Illumina [441,398]
cnv: N
study:
Genome-wide association study of rheumatoid arthritis in Koreans: population-specific loci as well as overlap with European susceptibility loci.


dbdate: 2011-04-29
author: Villard E
date: 2011-04-01
journal: Eur Heart J
link: http://www.ncbi.nlm.nih.gov/pubmed/21459883
trait: Dilated cardiomyopathy
initial_samplesize: 1,179 European ancestry cases, 1,108 European ancestry controls
replication_samplesize: 1,165 European ancestry cases, 1,302 European ancestry controls
region: 10q26.11
chrom: 10
reported_genes: BAG3
mapped_gene: BAG3
snp_gene_ids: 9531
strongest_risk_snp: rs2234962
snps: rs2234962
snp_id_current: 2234962
context: missense
pvalue_mlog: 11.39794000867204
ci_95: [1.22-1.89]
platform: Illumina [517,382](pooled)
cnv: N
study:
A genome-wide association study identifies two loci associated with heart failure due to dilated cardiomyopathy.


dbdate: 2011-04-13
author: Ligthart L
date: 2011-03-30
journal: Eur J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21448238
study: Meta-analysis of genome-wide association for migraine in six population-based European cohorts.
trait: Migraine
replication_samplesize: 2,957 European ancestry cases, 5,774 European ancestry controls
region: 15q25.3
chrom: 15
reported_genes: AGBL1
mapped_gene: AGBL1-AS1 - LINC00052
upstream_gene_id: 727915
downstream_gene_id: 145978
strongest_risk_snp: rs11636768
strongest_risk_allele: A
snps: rs11636768
snp_id_current: 11636768
context: Intergenic
pvalue_mlog: 6.30102999566398
ci_95: [NR]
platform: Affymetrix, Illumina & Perlegen [~2.5 million] (imputed)
cnv: N
initial_samplesize:
2,116 European ancestry cases, 7,318 European ancestry controls, 330 Dutch founder cases, 1,216 Dutch founder controls


dbdate: 2011-04-13
author: Miller EK
date: 2011-03-25
journal: Vaccine
link: http://www.ncbi.nlm.nih.gov/pubmed/21396408
trait: Vaccine-related adverse events
initial_samplesize: 6 European ancestry cases,55 European ancestry controls
region: 1q23.2
chrom: 1
reported_genes: Intergenic
mapped_gene: CRP - RPL27P2
upstream_gene_id: 1401
downstream_gene_id: 646446
strongest_risk_snp: rs11265263
snps: rs11265263
snp_id_current: 11265263
context: Intergenic
pvalue_mlog: 5.522878745280337
platform: Illumina [468,458]
cnv: N
study:
Atopy history and the genomics of wheezing after influenza vaccination in children 6-59 months of age.


dbdate: 2013-04-23
author: Deelen J
date: 2011-03-21
journal: Aging Cell
link: http://www.ncbi.nlm.nih.gov/pubmed/21418511
trait: Longevity
initial_samplesize: 403 European ancestry cases, 1,670 European ancestry controls
region: 19q13.32
chrom: 19
reported_genes: TOMM40, APOE
mapped_gene: TOMM40
snp_gene_ids: 10452
strongest_risk_snp: rs2075650
snps: rs2075650
snp_id_current: 2075650
context: intron
pvalue_mlog: 16.52287874528034
ci_95: [1.30-1.54]
platform: Illumina [516,721]
cnv: N
study:
Genome-wide association study identifies a single major locus contributing to survival into old age; the APOE locus revisited.

replication_samplesize:
1,578 European ancestry cases, 1,997 European ancestry controls, 1,208 Other ancestry cases, 2,090 Other ancestry controls, 960 cases, 1,825 controls


dbdate: 2011-04-13
author: Sehrawat B
date: 2011-03-19
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21424380
trait: Breast cancer
initial_samplesize: 302 European ancestry female cases, 321 European ancestry female controls
replication_samplesize: 1,153 European ancestry female cases, 1,215 European ancestry female controls
region: 5p15.2
chrom: 5
reported_genes: ROPN1L
mapped_gene: ROPN1L
snp_gene_ids: 83853
strongest_risk_snp: rs1092913
strongest_risk_allele: T
snps: rs1092913
snp_id_current: 1092913
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [1.24-1.69]
platform: Affymetrix [782,838]
cnv: N
study:
Potential novel candidate polymorphisms identified in genome-wide association study for breast cancer susceptibility.


dbdate: 2011-04-13
author: McKay JD
date: 2011-03-17
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21437268
trait: Upper aerodigestive tract cancers
initial_samplesize: 2,091 European ancestry cases, 8,334 European ancestry controls
replication_samplesize: 6,574 European ancestry cases, 7,892 European ancestry controls
region: 4q23
chrom: 4
reported_genes: ADH1B
mapped_gene: ADH1B
snp_gene_ids: 125
strongest_risk_snp: rs1229984
strongest_risk_allele: T
snps: rs1229984
snp_id_current: 1229984
context: missense
pvalue_mlog: 20
ci_95: [1.41-1.69]
platform: Illumina [294,620]
cnv: N
study:
A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium.


dbdate: 2011-04-12
author: Gharavi AG
date: 2011-03-13
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21399633
study: Genome-wide association study identifies susceptibility loci for IgA nephropathy.
trait: Nephropathy
initial_samplesize: 1,194 Han Chinese ancestry cases, 902 Han Chinese ancestry controls
region: 1q31.3
chrom: 1
reported_genes: CFH, CFHR3, CFHR1, CFHR4, CHFR2, CFHR5
mapped_gene: CFH
snp_gene_ids: 3075
strongest_risk_snp: rs6677604
snps: rs6677604
snp_id_current: 6677604
context: intron
pvalue_mlog: 9.522878745280336
ci_95: [NR]
platform: Illumina [498,322]
cnv: N
replication_samplesize:
712 Han Chinese ancestry cases, 748 Han Chinese ancestry controls, 1,238 European ancestry cases, 1,172 European ancestry controls


dbdate: 2011-04-11
author: Speliotes EK
date: 2011-03-10
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21423719
trait: Nonalcoholic fatty liver disease
initial_samplesize: 880 Amish individuals, 6,296 European ancestry individuals
replication_samplesize: 592 European ancestry cases, 1,405 European ancestry controls
region: 22q13.31
chrom: 22
reported_genes: PNPLA3
mapped_gene: PNPLA3
snp_gene_ids: 80339
strongest_risk_snp: rs738409
strongest_risk_allele: G
snps: rs738409
snp_id_current: 738409
context: missense
pvalue_mlog: 33.39794000867203
ci_95: [0.22-0.30] unit increase (GOLD)
platform: Affymetrix & Illumina [~2.4 million] (imputed)
cnv: N
study:
Genome-wide association analysis identifies variants associated with nonalcoholic fatty liver disease that have distinct effects on metabolic traits.


dbdate: 2011-04-08
author: Marciante KD
date: 2011-03-06
journal: Pharmacogenet Genomics
link: http://www.ncbi.nlm.nih.gov/pubmed/21386754
study: Cerivastatin, genetic variants, and the risk of rhabdomyolysis.
trait: Response to cerivastatin
region: 1q43
chrom: 1
reported_genes: RYR2
mapped_gene: RYR2
snp_gene_ids: 6262
strongest_risk_snp: rs2819742
strongest_risk_allele: G
snps: rs2819742
snp_id_current: 2819742
context: intron
pvalue_mlog: 6.698970004336019
ci_95: [1.59-2.78]
platform: Illumina [292,461]
cnv: N
initial_samplesize:
168 European ancestry cases, 17 Other ancestry cases, 636 European ancestry controls, 96 Other ancestry controls


dbdate: 2011-04-11
author: The Coronary Artery Disease (C4D) Genetics Consortium
date: 2011-03-06
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21378988
trait: Coronary heart disease
region: 9p21.3
chrom: 9
reported_genes: Intergenic
mapped_gene: CDKN2B-AS1
snp_gene_ids: 100048912
strongest_risk_snp: rs4977574
strongest_risk_allele: G
snps: rs4977574
snp_id_current: 4977574
context: intron
pvalue_mlog: 24.69897000433602
ci_95: [1.16-1.25]
platform: Illumina [574,919]
cnv: N
study:
A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease.

initial_samplesize:
8,424 European ancestry cases, 7,268 European ancestry controls, 6,996 South Asian ancestry cases, 7,794 South Asian ancestry controls

replication_samplesize:
18,049 European ancestry cases, 16,357 European ancestry controls, 3,359 South Asian ancestry cases, 2,828 South Asian ancestry controls


dbdate: 2011-04-07
author: Chung SA
date: 2011-03-03
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21408207
trait: Systemic lupus erythematosus
region: 6p21.33
chrom: 6
reported_genes: TNXB
mapped_gene: TNXB
snp_gene_ids: 7148
strongest_risk_snp: rs1150754
strongest_risk_allele: A
snps: rs1150754
snp_id_current: 1150754
context: intron
pvalue_mlog: 28.22184874961635
ci_95: [1.93-2.53]
platform: Illumina [421,318] (imputed)
cnv: N
study:
Differential genetic associations for systemic lupus erythematosus based on anti-dsDNA autoantibody production.

initial_samplesize:
811 anti-dsDNA positive European ancestry cases, 906 anti-dsDNA negative European ancestry cases, 4,813 European ancestry controls


dbdate: 2011-04-07
author: Takeuchi F
date: 2011-03-01
journal: Circ J
link: http://www.ncbi.nlm.nih.gov/pubmed/21372407
trait: Drinking behavior
initial_samplesize: 733 Japanese ancestry cases, 729 Japanese ancestry controls
region: 12q24.12
chrom: 12
reported_genes: ALDH2, BRAP
mapped_gene: ALDH2
snp_gene_ids: 217
strongest_risk_snp: rs671
snps: rs671
snp_id_current: 671
context: missense
pvalue_mlog: 210.397940008672
ci_95: [5.56-7.14]
platform: Illumina [456,827]
cnv: N
study:
Confirmation of ALDH2 as a Major locus of drinking behavior and of its variants regulating multiple metabolic phenotypes in a Japanese population.

replication_samplesize:
2,794 Japanese ancestry drinkers, 1,521 Japanese ancestry chance drinkers, 1,351 Japanese ancestry non-drinkers


dbdate: 2013-04-30
author: Kim Y
date: 2011-02-28
journal: World J Biol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/23480133
trait: Vascular dementia
initial_samplesize: 84 Korean ancestry cases, 200 Korean ancestry controls
replication_samplesize: 113 Korean ancestry cases, 255 Korean ancestry controls
region: 9q22.2
chrom: 9
reported_genes: SYK
mapped_gene: SYK
snp_gene_ids: 6850
strongest_risk_snp: rs290227
strongest_risk_allele: G
snps: rs290227
snp_id_current: 290227
context: intron
pvalue_mlog: 10.15490195998574
ci_95: [1.73-2.78]
platform: NR [300,640]
cnv: N
study:
Association of intronic sequence variant in the gene encoding spleen tyrosine kinase with susceptibility to vascular dementia.


dbdate: 2011-04-06
author: Bol SM
date: 2011-02-25
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/21364930
trait: HIV-1 replication
initial_samplesize: 191 European ancestry individuals
replication_samplesize: 31 individuals
region: 21q22.13
chrom: 21
reported_genes: DYRK1A
mapped_gene: DYRK1A
snp_gene_ids: 1859
strongest_risk_snp: rs12483205
snps: rs12483205
snp_id_current: 12483205
context: intron
pvalue_mlog: 5.301029995663981
platform: Illumina [494,656]
cnv: N
study:
Genome-wide association study identifies single nucleotide polymorphism in DYRK1A associated with replication of HIV-1 in monocyte-derived macrophages.


dbdate: 2011-04-06
author: Hu X
date: 2011-02-24
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/21390209
trait: Alzheimer's disease (late onset)
initial_samplesize: 1,831 European ancestry cases, 1,764 European ancestry controls
replication_samplesize: 751 cases, 751 controls
region: 2q14.3
chrom: 2
reported_genes: BIN1
mapped_gene: BIN1 - CYP27C1
upstream_gene_id: 274
downstream_gene_id: 339761
strongest_risk_snp: rs744373
snps: rs744373
snp_id_current: 744373
context: Intergenic
pvalue_mlog: 10
ci_95: [NR]
platform: Affymetrix and Illumina [NR] (imputed)
cnv: N
study:
Meta-analysis for genome-wide association study identifies multiple variants at the BIN1 locus associated with late-onset Alzheimer's disease.


dbdate: 2011-04-06
author: Zhernakova A
date: 2011-02-24
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21383967
trait: Celiac disease and Rheumatoid arthritis
region: 12q24.12
chrom: 12
reported_genes: SH2B3
mapped_gene: ATXN2
snp_gene_ids: 6311
strongest_risk_snp: rs653178
strongest_risk_allele: C
snps: rs653178
snp_id_current: 653178
context: intron
pvalue_mlog: 18.52287874528033
platform: Illumina [472,854]
cnv: N
study:
Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.

initial_samplesize:
4,533 European ancestry celiac disease cases, 5,539 European ancestry rheumatoid arthritis cases, 27,981 European ancestry controls

replication_samplesize:
2,169 European ancestry celiac disease cases, 2,845 European ancestry rheumatoid arthritis cases, European ancestry 7,199 controls


dbdate: 2011-04-06
author: Cichon S
date: 2011-02-23
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21353194
trait: Bipolar disorder
initial_samplesize: 682 European ancestry cases, 1,300 European ancestry controls
replication_samplesize: 7,759 European ancestry cases, 34,062 European ancestry controls
region: 19p13.11
chrom: 19
reported_genes: NCAN
mapped_gene: NCAN
snp_gene_ids: 1463
strongest_risk_snp: rs1064395
strongest_risk_allele: A
snps: rs1064395
snp_id_current: 1064395
context: UTR-3
pvalue_mlog: 8.698970004336019
ci_95: [NR]
platform: Illumina [511,978]
cnv: N
study:
Genome-wide association study identifies genetic variation in neurocan as a susceptibility factor for bipolar disorder.


dbdate: 2011-04-06
author: Liu X
date: 2011-02-22
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/21339755
trait: 5-HTT brain serotonin transporter levels
initial_samplesize: 16 unmedicated bipolar disorder cases, 17 unmedicated major depressive disorder cases, 22 controls
replication_samplesize: 51 European ancestry individuals
region: 2p22.1
chrom: 2
reported_genes: GALM
mapped_gene: GALM
snp_gene_ids: 130589
strongest_risk_snp: rs6741892
snps: rs6741892
snp_id_current: 6741892
context: missense
pvalue_mlog: 5.301029995663981
platform: Illumina [93,247]
cnv: N
study:
A non-synonymous polymorphism in galactose mutarotase (GALM) is associated with serotonin transporter binding potential in the human thalamus: results of a genome-wide association study.


dbdate: 2011-04-04
author: Bhatnagar P
date: 2011-02-17
journal: J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21326311
trait: F-cell distribution
initial_samplesize: 440 African American individuals
region: 5q22.2
chrom: 5
reported_genes: TSSK1
mapped_gene: MCC
snp_gene_ids: 4163
strongest_risk_snp: rs1318772
strongest_risk_allele: G
snps: rs1318772
snp_id_current: 1318772
context: intron
pvalue_mlog: 5.999999999999999
ci_95: [0.54-1.28] unit decrease
platform: Illumina [660,740]
cnv: N
study:
Genome-wide association study identifies genetic variants influencing F-cell levels in sickle-cell patients.


dbdate: 2011-04-04
author: Jin Y
date: 2011-02-17
journal: J Invest Dermatol
link: http://www.ncbi.nlm.nih.gov/pubmed/21326295
trait: Vitiligo
initial_samplesize: 1,339 European ancestry cases
replication_samplesize: 677 European ancestry cases
region: 6p21.32
chrom: 6
reported_genes: C6orf10, BTNL2
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs7758128
strongest_risk_allele: A
snps: rs7758128
snp_id_current: 7758128
pvalue_mlog: 10.09691001300805
platform: Illumina [520,460]
cnv: N
study:
Genome-wide analysis identifies a quantitative trait locus in the MHC class II region associated with generalized vitiligo age of onset.


dbdate: 2011-04-04
author: Wijsman EM
date: 2011-02-17
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21379329
trait: Alzheimer's disease (late onset)
initial_samplesize: 1,848 European ancestry affected individuals, 1,991 European ancestry unaffected individuals
region: 10p14
chrom: 10
reported_genes: CUGBP2
mapped_gene: CELF2
snp_gene_ids: 10659
strongest_risk_snp: rs62209
strongest_risk_allele: C
snps: rs62209
snp_id_current: 62209
context: intron
pvalue_mlog: 6.698970004336019
ci_95: [1.56-2.67] (among APOE E4 homozygotes)
platform: Illumina [565,336]
cnv: N
study:
Genome-wide association of familial late-onset Alzheimer's disease replicates BIN1 and CLU and nominates CUGBP2 in interaction with APOE.

replication_samplesize:
231 Caribbean Hispanic cases, 187 Caribbean Hispanic controls, 386 European ancestry cases, 386 European ancestry controls


dbdate: 2011-04-04
author: Kendler KS
date: 2011-02-11
journal: Alcohol Clin Exp Res
link: http://www.ncbi.nlm.nih.gov/pubmed/21314694
trait: Alcohol dependence
initial_samplesize: 2,357 European ancestry individuals, 812 African American individuals
region: 3p25.2
chrom: 3
reported_genes: C3orf31
mapped_gene: MARK2P14 - SYN2
upstream_gene_id: 100631261
downstream_gene_id: 6854
strongest_risk_snp: rs6777876
strongest_risk_allele: G
snps: rs6777876
snp_id_current: 6777876
context: Intergenic
pvalue_mlog: 6.397940008672037
platform: Affymetrix [NR]
cnv: N
study:
Genomewide association analysis of symptoms of alcohol dependence in the molecular genetics of schizophrenia (MGS2) control sample.


dbdate: 2011-04-07
author: Lettre G
date: 2011-02-10
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21347282
trait: Coronary heart disease
initial_samplesize: 8,090 African American individuals
replication_samplesize: 8,849 African American or African-Caribbean ancestry individuals
region: 13q31.2
chrom: 13
reported_genes: Intergenic
mapped_gene: TET1P1 - RPL29P29
upstream_gene_id: 441662
downstream_gene_id: 100271474
strongest_risk_snp: rs7323893
strongest_risk_allele: T
snps: rs7323893
snp_id_current: 7323893
context: Intergenic
pvalue_mlog: 7
ci_95: [0.09-0.19] SD decrease
platform: Affymetrix [~2.74 million] (imputed)
cnv: N
study:
Genome-wide association study of coronary heart disease and its risk factors in 8,090 African Americans: the NHLBI CARe Project.


dbdate: 2011-03-29
author: Khor CC
date: 2011-02-09
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21307088
trait: Optic disc parameters
initial_samplesize: 2,132 Indian ancestry individuals, 2,313 Malay ancestry individuals
replication_samplesize: 9,326 European ancestry individuals
region: 22q13.1
chrom: 22
reported_genes: CARD10
mapped_gene: CARD10 - CDC42EP1
upstream_gene_id: 29775
downstream_gene_id: 11135
strongest_risk_snp: rs9607469
strongest_risk_allele: A
snps: rs9607469
snp_id_current: 9607469
context: Intergenic
pvalue_mlog: 11.52287874528034
ci_95: [0.04-0.06] mm2 increase
platform: Illumina [551,808]
cnv: N
study:
Genome-wide association studies in Asians confirm the involvement of ATOH7 and TGFBR3, and further identify CARD10 as a novel locus influencing optic disc area.


dbdate: 2011-03-23
author: Huang YC
date: 2011-02-08
journal: Ophthalmology
link: http://www.ncbi.nlm.nih.gov/pubmed/21310492
study: Genome-wide association study of diabetic retinopathy in a Taiwanese population.
trait: Diabetic retinopathy
region: 1p32.1
chrom: 1
reported_genes: MYSM1
mapped_gene: MYSM1
snp_gene_ids: 114803
strongest_risk_snp: rs2811893
strongest_risk_allele: T
snps: rs2811893
snp_id_current: 2811893
context: intron
pvalue_mlog: 6.522878745280337
platform: Illumina [~550,000]
cnv: N
initial_samplesize:
174 Han Chinese ancestry Type 2 diabetics with diabetic retinopathy, 575 Han Chinese ancestry Type 2 diabetics without diabetic retinopathy, 100 Han Chinese ancestry controls


dbdate: 2011-03-28
author: Dehghan A
date: 2011-02-07
journal: Circulation
link: http://www.ncbi.nlm.nih.gov/pubmed/21300955
trait: C-reactive protein
initial_samplesize: 66,185 European ancestry individuals
replication_samplesize: 16,540 European ancestry individuals
region: 18p11.21
chrom: 18
reported_genes: PTPN2
mapped_gene: PTPN2
snp_gene_ids: 5771
strongest_risk_snp: rs2847281
strongest_risk_allele: A
snps: rs2847281
snp_id_current: 2847281
context: intron
pvalue_mlog: 7.698970004336018
ci_95: [0.02-0.04] unit increase
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Meta-analysis of genome-wide association studies in &gt;80 000 subjects identifies multiple loci for C-reactive protein levels.


dbdate: 2011-03-29
author: Anderson CA
date: 2011-02-06
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21297633
trait: Ulcerative colitis
initial_samplesize: 6,687 European ancestry cases, 19,718 European ancestry controls
replication_samplesize: 9,628 European ancestry cases, 12,917 European ancestry controls
region: 1p36.13
chrom: 1
reported_genes: Intergenic
mapped_gene: RNF186 - OTUD3
upstream_gene_id: 54546
downstream_gene_id: 23252
strongest_risk_snp: rs6426833
strongest_risk_allele: A
snps: rs6426833
snp_id_current: 6426833
context: Intergenic
pvalue_mlog: 34.39794000867204
ci_95: [1.25-1.35]
platform: Affymetrix & Illumina [~1.1 million] (imputed)
cnv: N
study:
Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.


dbdate: 2011-03-18
author: Tsai FJ
date: 2011-02-04
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/21326860
trait: Kawasaki disease
initial_samplesize: 250 Han Chinese ancestry cases, 446 Han Chinese ancestry controls
replication_samplesize: 208 Han Chinese ancestry cases, 366 Han Chinese ancestry controls
region: 14q32.33
chrom: 14
reported_genes: IGHV
mapped_gene: IGH
snp_gene_ids: 3492
strongest_risk_snp: rs10129255
strongest_risk_allele: A
snps: rs10129255
snp_id_current: 10129255
pvalue_mlog: 5.154901959985742
ci_95: [1.116-1.551]
platform: Affymetrix [723,638]
cnv: N
study:
Identification of novel susceptibility Loci for kawasaki disease in a Han chinese population by a genome-wide association study.


dbdate: 2011-03-18
author: Nalls MA
date: 2011-02-01
journal: Lancet
link: http://www.ncbi.nlm.nih.gov/pubmed/21292315
trait: Parkinson's disease
initial_samplesize: 5,333 European ancestry cases, 12,019 European ancestry controls
replication_samplesize: 7,053 European ancestry cases, 9,007 European ancestry controls
region: 1q22
chrom: 1
reported_genes: SYT11
mapped_gene: RAB25
snp_gene_ids: 57111
strongest_risk_snp: rs34372695
strongest_risk_allele: T
snps: rs34372695
snp_id_current: 34372695
context: nearGene-5
pvalue_mlog: 11.39794000867204
ci_95: [1.35-1.59]
platform: Illumina [7,689,524] (imputed)
cnv: N
study:
Imputation of sequence variants for identification of genetic risks for Parkinson's disease: a meta-analysis of genome-wide association studies.


dbdate: 2011-03-28
author: Parsa A
date: 2011-02-01
journal: Clin Transl Sci
link: http://www.ncbi.nlm.nih.gov/pubmed/21348951
trait: Cardiac hypertrophy
initial_samplesize: 851 Old Order Amish individuals
region: 10q25.1
chrom: 10
reported_genes: COL17A1
mapped_gene: COL17A1
snp_gene_ids: 1308
strongest_risk_snp: rs1320448
snps: rs1320448
snp_id_current: 1320448
context: nearGene-5
pvalue_mlog: 7.698970004336018
platform: Affymetrix [361,034]
cnv: N
study:
Hypertrophy-associated polymorphisms ascertained in a founder cohort applied to heart failure risk and mortality.


dbdate: 2012-01-20
author: Chen X
date: 2011-01-27
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/21298047
trait: Substance dependence
initial_samplesize: 2,524 European ancestry individuals, 1,103 African ancestry individuals
region: 11q24.2
chrom: 11
reported_genes: PKNOX2
mapped_gene: PKNOX2
snp_gene_ids: 63876
strongest_risk_snp: rs12284594
strongest_risk_allele: G
snps: rs12284594
snp_id_current: 12284594
context: intron
pvalue_mlog: 7.154901959985742
ci_95: [NR]
platform: Illumina [830,696]
cnv: N
study:
The nuclear transcription factor PKNOX2 is a candidate gene for substance dependence in European-origin women.


dbdate: 2011-03-02
author: Del Greco M F
date: 2011-01-27
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21273288
trait: Natriuretic peptide levels
initial_samplesize: 1,325 European ancestry individuals
replication_samplesize: 1,746 European ancestry individuals
region: 1p36.22
chrom: 1
reported_genes: CLCN6
mapped_gene: CLCN6;NPPA-AS1
snp_gene_ids: 1185;100379251
strongest_risk_snp: rs1023252
strongest_risk_allele: T
snps: rs1023252
snp_id_current: 1023252
context: intron;nearGene-5
pvalue_mlog: 15.39794000867204
ci_95: [0.16-0.24] unit increase
platform: Illumina [~2.5 million] (imputed)
cnv: N
study:
Genome-wide association analysis and fine mapping of NT-proBNP level provide novel insight into the role of the MTHFR-CLCN6-NPPA-NPPB gene cluster.


dbdate: 2011-03-18
author: Festen EA
date: 2011-01-27
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21298027
trait: Crohn's disease and celiac disease
region: 2p16.1
chrom: 2
reported_genes: PUS10
mapped_gene: PUS10
snp_gene_ids: 150962
strongest_risk_snp: rs10188217
strongest_risk_allele: C
snps: rs10188217
snp_id_current: 10188217
context: intron
pvalue_mlog: 11
platform: Affymetrix & Illumina [471,504]
cnv: N
study:
A meta-analysis of genome-wide association scans identifies IL18RAP, PTPN2, TAGAP, and PUS10 as shared risk loci for Crohn's disease and celiac disease.

initial_samplesize:
3,230 European ancestry Crohn's disease cases, 768 European ancestry celiac disease cases, 6,251 European ancestry controls

replication_samplesize:
1,835 European ancestry Crohn's disease cases, 3,149 European ancestry celiac disease cases, 6,383 European ancestry controls


dbdate: 2011-02-23
author: Reilly MP
date: 2011-01-14
journal: Lancet
link: http://www.ncbi.nlm.nih.gov/pubmed/21239051
trait: Coronary heart disease
region: 15q25.1
chrom: 15
reported_genes: ADAMTS7
mapped_gene: ADAMTS7
snp_gene_ids: 11173
strongest_risk_snp: rs1994016
strongest_risk_allele: C
snps: rs1994016
snp_id_current: 1994016
context: intron
pvalue_mlog: 12.30102999566398
ci_95: [1.13-1.24]
platform: Affymetrix & Illumina [~2.4 million] (imputed)
cnv: N
study:
Identification of ADAMTS7 as a novel locus for coronary atherosclerosis and association of ABO with myocardial infarction in the presence of coronary atherosclerosis: two genome-wide association studies.

initial_samplesize:
1,808 European ancestry AngCAD cases, 915 European ancestry AngCAD controls, 4,572 European ancestry AngCAD with MI cases, 2,739 European ancestry AngCAD without MI controls

replication_samplesize:
10,585 European ancestry AngCAD cases, 6,468 European ancestry AngCAD controls, 1,211 European ancestry AngCAD with MI cases, 905 European ancestry AngCAD without MI controls


dbdate: 2011-02-23
author: Ochi H
date: 2011-01-12
journal: J Gen Virol
link: http://www.ncbi.nlm.nih.gov/pubmed/21228123
trait: Response to hepatitis C treatment
initial_samplesize: 2,101 East Asian ancestry cases, 282 Japanese ancestry controls
region: 19q13.2
chrom: 19
reported_genes: IL28B
mapped_gene: IFNL4 - MSRB1P1
upstream_gene_id: 101180976
downstream_gene_id: 441849
strongest_risk_snp: rs8099917
strongest_risk_allele: G
snps: rs8099917
snp_id_current: 8099917
context: Intergenic
pvalue_mlog: 20
ci_95: [2.4-3.8]
platform: Illumina [510,537]
cnv: N
study:
IL-28B predicts response to chronic hepatitis C therapy--fine-mapping and replication study in Asian populations.


dbdate: 2011-03-04
author: Wineinger NE
date: 2011-01-11
journal: BMC Med Genomics
link: http://www.ncbi.nlm.nih.gov/pubmed/21223598
trait: Aortic root size
initial_samplesize: 1,086 African American individuals
region: 3p14.2
chrom: 3
reported_genes: FHIT
mapped_gene: FHIT
snp_gene_ids: 2272
strongest_risk_snp: rs1825630
snps: rs1825630
snp_id_current: 1825630
context: intron
pvalue_mlog: 5.096910013008055
ci_95: [0.053-0.136] cm increase
platform: Affymetrix [NR]
cnv: N
study:
Genome-wide joint SNP and CNV analysis of aortic root diameter in African Americans: the HyperGEN study.


dbdate: 2011-01-27
author: Kim JJ
date: 2011-01-09
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21221998
trait: Kawasaki disease
initial_samplesize: 186 Korean ancestry child cases, 600 Korean ancestry controls
replication_samplesize: 514 East Asian ancestry child cases, 1,042 East Asian ancestry controls
region: 1p32.2
chrom: 1
reported_genes: DAB1
mapped_gene: VKORC1P2 - OMA1
upstream_gene_id: 414357
downstream_gene_id: 115209
strongest_risk_snp: rs527409
strongest_risk_allele: T
snps: rs527409
snp_id_current: 527409
context: Intergenic
pvalue_mlog: 5.999999999999999
ci_95: [1.85-4.54]
platform: Affymetrix [641,760]
cnv: N
study:
A genome-wide association analysis reveals 1p31 and 2p13.3 as susceptibility loci for Kawasaki disease.


dbdate: 2011-02-22
author: Kaplan RC
date: 2011-01-07
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21216879
trait: Insulin-like growth factors
initial_samplesize: 10,280 European ancestry individuals
region: 7p12.3
chrom: 7
reported_genes: IGFBP3
mapped_gene: IGFBP3 - FTLP15
upstream_gene_id: 3486
downstream_gene_id: 442304
strongest_risk_snp: rs11977526
strongest_risk_allele: A
snps: rs11977526
snp_id_current: 11977526
context: Intergenic
pvalue_mlog: 100.5228787452803
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
A genome-wide association study identifies novel loci associated with circulating IGF-I and IGFBP-3.


dbdate: 2011-01-27
author: Sharma S
date: 2011-01-07
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21216876
trait: Adolescent idiopathic scoliosis
initial_samplesize: 1,113 individuals from 418 families
replication_samplesize: 562 European ancestry cases, 137 cases, 666 European ancestry controls, 2,126 controls
region: 3p26.3
chrom: 3
reported_genes: CHL1,LOC642891
mapped_gene: A1BG - CHL1
downstream_gene_id: 10752
strongest_risk_snp: rs10510181
strongest_risk_allele: A
snps: rs10510181
snp_id_current: 10510181
context: Intergenic
pvalue_mlog: 6.096910013008056
ci_95: [1.20-1.58]
platform: Illumina [326,498]
cnv: N
study:
Genome-wide association studies of adolescent idiopathic scoliosis suggest candidate susceptibility genes.


dbdate: 2011-02-03
author: Pichler I
date: 2011-01-04
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21208937
trait: Iron levels
initial_samplesize: Up to 5,633 European ancestry individuals
replication_samplesize: Up to 3,457 European ancestry individuals
region: 7q22.1
chrom: 7
reported_genes: TFR2
mapped_gene: TFR2
snp_gene_ids: 7036
strongest_risk_snp: rs7385804
strongest_risk_allele: A
snps: rs7385804
snp_id_current: 7385804
context: intron
pvalue_mlog: 7.154901959985742
ci_95: [2.05-4.41] ug/dl increase
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Identification of a common variant in the TFR2 gene implicated in the physiological regulation of serum iron levels.


dbdate: 2011-01-16
author: Okada Y
date: 2010-12-31
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21196492
trait: C-reactive protein
initial_samplesize: 10,112 Japanese ancestry individuals
replication_samplesize: 2,742 Japanese ancestry individuals
region: 1q23.2
chrom: 1
reported_genes: CRP
mapped_gene: CRP
snp_gene_ids: 1401
strongest_risk_snp: rs3093059
strongest_risk_allele: G
snps: rs3093059
snp_id_current: 3093059
context: nearGene-5
pvalue_mlog: 20.39794000867204
ci_95: [0.13-0.19] unit increase
platform: Illumina [477,784]
cnv: N
study:
Genome-wide association study for C-reactive protein levels identified pleiotropic associations in the IL6 locus.


dbdate: 2011-01-15
author: Lauc G
date: 2010-12-23
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21203500
trait: N-glycan levels
initial_samplesize: 2,559 European ancestry individuals
region: 14q23.3
chrom: 14
reported_genes: FUT8
mapped_gene: PTBP1P - MIR4708
upstream_gene_id: 122888
downstream_gene_id: 100616176
strongest_risk_snp: rs7159888
strongest_risk_allele: A
snps: rs7159888
snp_id_current: 7159888
context: Intergenic
pvalue_mlog: 17.52287874528034
ci_95: [0.20-0.32] unit increase
platform: Illumina [~300,000]
cnv: N
study:
Genomics meets glycomics-the first GWAS study of human N-Glycome identifies HNF1&#x003b1; as a master regulator of plasma protein fucosylation.


dbdate: 2011-01-18
author: Moyer AM
date: 2010-12-22
journal: Toxicol Sci
link: http://www.ncbi.nlm.nih.gov/pubmed/21177773
study: Acetaminophen-NAPQI hepatotoxicity: a cell line model system genome-wide association study.
trait: Response to acetaminophen (hepatotoxicity)
region: 3p11.1
chrom: 3
reported_genes: C3orf38
mapped_gene: ABCF2P1 - NDUFA5P5
upstream_gene_id: 344653
downstream_gene_id: 100130327
strongest_risk_snp: rs2880961
snps: rs2880961
snp_id_current: 2880961
context: Intergenic
pvalue_mlog: 6.698970004336019
platform: Affymetrix & Illumina [1,348,864]
cnv: N
initial_samplesize:
60 European ancestry lymphoblastoid cell lines, 56 African American lymphoblastoid cell lines, 60 Han Chinese American lymphoblastoid cell lines


dbdate: 2014-07-02
author: Padyukov L
date: 2010-12-14
journal: Ann Rheum Dis
link: http://www.ncbi.nlm.nih.gov/pubmed/21156761
trait: Rheumatoid arthritis
replication_samplesize: 887 European ancestry ACPA positive RA cases, 1,218 European ancestry controls
region: 2p21
chrom: 2
reported_genes: RPS12P4
mapped_gene: RPS12P4 - C2orf91
upstream_gene_id: 391370
downstream_gene_id: 400950
strongest_risk_snp: rs4305317
snps: rs4305317
snp_id_current: 4305317
context: Intergenic
pvalue_mlog: 5.698970004336018
ci_95: [1.25-1.69]
platform: Illumina [1,723,056] (imputed)
cnv: N
study:
A genome-wide association study suggests contrasting associations in ACPA-positive versus ACPA-negative rheumatoid arthritis.

initial_samplesize:
1,147 European ancestry ACPA positive RA cases, 774 European ancestry ACPA negative RA cases, 1,079 European ancestry controls


dbdate: 2011-01-19
author: Petrovski S
date: 2010-12-14
journal: AIDS
link: http://www.ncbi.nlm.nih.gov/pubmed/21160409
trait: HIV-1 susceptibility
initial_samplesize: 531 Sub-Saharan African ancestry cases, 848 Sub-Saharan African ancestry controls
region: 9p24.1
chrom: 9
reported_genes: AL591509.5
mapped_gene: PPIAP33 - TMEM261
upstream_gene_id: 392285
downstream_gene_id: 90871
strongest_risk_snp: rs842304
snps: rs842304
snp_id_current: 842304
context: Intergenic
pvalue_mlog: 5.397940008672037
platform: Illumina [~800,000]
cnv: N
study:
Common human genetic variants and HIV-1 susceptibility: a genome-wide survey in a homogeneous African population.


dbdate: 2011-01-16
author: Chen ZJ
date: 2010-12-12
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21151128
trait: Polycystic ovary syndrome
initial_samplesize: 744 Han Chinese ancestry cases, 895 Han Chinese ancestry controls
replication_samplesize: 3,338 Han Chinese ancestry cases, 5,792 Han Chinese ancestry controls
region: 2p16.3
chrom: 2
reported_genes: GTF2A1L,LHCGR,FSHR
mapped_gene: LHCGR;STON1-GTF2A1L
snp_gene_ids: 3973;286749
strongest_risk_snp: rs13405728
strongest_risk_allele: A
snps: rs13405728
snp_id_current: 13405728
context: intron;intron
pvalue_mlog: 20.09691001300805
ci_95: [1.30-1.49]
platform: Affymetrix [611,633]
cnv: N
study:
Genome-wide association study identifies susceptibility loci for polycystic ovary syndrome on chromosome 2p16.3, 2p21 and 9q33.3.


dbdate: 2011-01-15
author: Melum E
date: 2010-12-12
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21151127
trait: Primary sclerosing cholangitis
initial_samplesize: 715 European ancestry cases, 2,962 European ancestry controls
replication_samplesize: 1,025 European ancestry cases, 2,174 European ancestry controls
region: 3p21.31
chrom: 3
reported_genes: MST1
mapped_gene: MST1
snp_gene_ids: 4485
strongest_risk_snp: rs3197999
snps: rs3197999
snp_id_current: 3197999
context: missense
pvalue_mlog: 16
ci_95: [1.24-1.56]
platform: Affymetrix [2,466,182] (imputed)
cnv: N
study:
Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci.


dbdate: 2011-01-14
author: Carrasquillo MM
date: 2010-12-10
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21087763
trait: Progranulin levels
initial_samplesize: 518 European ancestry controls
replication_samplesize: 459 European ancestry controls
region: 1p13.3
chrom: 1
reported_genes: SORT1,CELSR2,PSRC1
mapped_gene: CELSR2
snp_gene_ids: 1952
strongest_risk_snp: rs646776
strongest_risk_allele: G
snps: rs646776
snp_id_current: 646776
context: nearGene-3
pvalue_mlog: 29.69897000433602
ci_95: [0.16-0.20] ng/ml decrease
platform: Illumina [313,504]
cnv: N
study:
Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma.


dbdate: 2011-01-15
author: Oexle K
date: 2010-12-10
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21149283
trait: Iron status biomarkers
initial_samplesize: Up to 6,616 individuals
region: 6p22.2
chrom: 6
reported_genes: HFE
mapped_gene: SLC17A1 - SLC17A3
upstream_gene_id: 6568
downstream_gene_id: 10786
strongest_risk_snp: rs1408272
strongest_risk_allele: T
snps: rs1408272
snp_id_current: 1408272
context: Intergenic
pvalue_mlog: 8.045757490560675
ci_95: [0.03-0.05] unit increase
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Novel association to the proprotein convertase PCSK7 gene locus revealed by analysing soluble transferrin receptor (sTfR) levels.


dbdate: 2011-01-11
author: Ferreira MA
date: 2010-12-08
journal: Eur J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21150878
trait: Asthma
initial_samplesize: 986 European ancestry cases, 1,846 European ancestry controls
replication_samplesize: 391 European ancestry cases, 213 European ancestry controls
region: 17q12
chrom: 17
reported_genes: ORMDL3
mapped_gene: LOC101928947
snp_gene_ids: 101928947
strongest_risk_snp: rs6503525
strongest_risk_allele: C
snps: rs6503525
snp_id_current: 6503525
context: intron
pvalue_mlog: 6.30102999566398
ci_95: [NR]
platform: Illumina [~2.38 million] (imputed)
cnv: N
study:
Association between ORMDL3, IL1RL1 and a deletion on chromosome 17q21 with asthma risk in Australia.


dbdate: 2011-01-11
author: Walsh KM
date: 2010-12-07
journal: Endocr Relat Cancer
link: http://www.ncbi.nlm.nih.gov/pubmed/21139019
trait: Ileal carcinoids
initial_samplesize: 239 European ancestry cases, 107 European ancestry controls
region: 20p12.1
chrom: 20
reported_genes: KIF16B
mapped_gene: KIF16B
snp_gene_ids: 55614
strongest_risk_snp: rs2208059
snps: rs2208059
snp_id_current: 2208059
context: intron
pvalue_mlog: 6.397940008672037
ci_95: [1.72-3.42]
platform: Illumina [308,330]
cnv: N
study:
A pilot genome-wide association study shows genomic variants enriched in the non-tumor cells of patients with well-differentiated neuroendocrine tumors of the ileum.


dbdate: 2011-01-15
author: Purdue MP
date: 2010-12-05
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21131975
trait: Renal cell carcinoma
initial_samplesize: 3,772 European ancestry cases, 8,505 European ancestry controls
replication_samplesize: 2,198 European ancestry cases, 4,918 European ancestry controls
region: 2p21
chrom: 2
reported_genes: EPAS1
mapped_gene: EPAS1
snp_gene_ids: 2034
strongest_risk_snp: rs7579899
snps: rs7579899
snp_id_current: 7579899
context: intron
pvalue_mlog: 8.698970004336019
ci_95: [1.10-1.21]
platform: Illumina [586,069]
cnv: N
study:
Genome-wide association study of renal cell carcinoma identifies two susceptibility loci on 2p21 and 11q13.3.


dbdate: 2011-01-10
author: Clifford RJ
date: 2010-12-01
journal: Hepatology
link: http://www.ncbi.nlm.nih.gov/pubmed/21105107
trait: Hepatocellular carcinoma
initial_samplesize: 180 Korean ancestry cases, 271 Korean ancestry controls
replication_samplesize: 206 Korean ancestry cases, 416 East Asian ancestry controls,
region: 3p22.3
chrom: 3
reported_genes: GLB1
mapped_gene: CCR4 - GLB1
upstream_gene_id: 1233
downstream_gene_id: 2720
strongest_risk_snp: rs4678680
snps: rs4678680
snp_id_current: 4678680
context: Intergenic
pvalue_mlog: 6.698970004336019
ci_95: [1.68-3.08]
platform: Affymetrix [658,897]
cnv: N
study:
Genetic variations at loci involved in the immune response are risk factors for hepatocellular carcinoma.


dbdate: 2011-01-12
author: Kim S
date: 2010-12-01
journal: Neurology
link: http://www.ncbi.nlm.nih.gov/pubmed/21123754
study: Genome-wide association study of CSF biomarkers Abeta1-42, t-tau, and p-tau181p in the ADNI cohort.
trait: Alzheimer's disease biomarkers
region: 2q23.1
chrom: 2
reported_genes: EPC2
mapped_gene: EPC2 - UBBP3
upstream_gene_id: 26122
downstream_gene_id: 23667
strongest_risk_snp: rs2121433
snps: rs2121433
snp_id_current: 2121433
context: Intergenic
pvalue_mlog: 5.999999999999999
platform: Illumina [322,557]
cnv: N
initial_samplesize:
96 European ancestry Alzheimer disease cases, 176 European ancestry individuals with mild cognitive impairment, 102 European ancestry controls


dbdate: 2014-07-01
author: Mick E
date: 2010-12-01
journal: Prog Neuropsychopharmacol Biol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/21130132
trait: Response to methylphenidate treatment in attention-deficit/hyperactivity disorder (blood pressure)
initial_samplesize: 140 child cases
region: 2p11.2
chrom: 2
reported_genes: PTCD3
mapped_gene: PTCD3
snp_gene_ids: 55037
strongest_risk_snp: rs2241437
strongest_risk_allele: C
snps: rs2241437
snp_id_current: 2241437
context: intron
pvalue_mlog: 5.522878745280337
platform: Affymetrix [316,934]
cnv: N
study:
Genome-wide association study of blood pressure response to methylphenidate treatment of attention-deficit/hyperactivity disorder.


dbdate: 2011-01-12
author: Furney SJ
date: 2010-11-30
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/21116278
trait: Entorhinal cortical thickness
region: 3p22.3
chrom: 3
reported_genes: ARPP-21
mapped_gene: LOC101928135
snp_gene_ids: 101928135
strongest_risk_snp: rs11129640
snps: rs11129640
snp_id_current: 11129640
context: intron
pvalue_mlog: 7.221848749616355
ci_95: [NR] unit decrease (main effect)
platform: Illumina [488,911]
cnv: N
study:
Genome-wide association with MRI atrophy measures as a quantitative trait locus for Alzheimer's disease.

initial_samplesize:
Up to 434 European ancestry MCI cases, 245 European ancestry AD cases, 284 European ancestry controls


dbdate: 2010-12-09
author: Wu C
date: 2010-11-30
journal: Cancer Res
link: http://www.ncbi.nlm.nih.gov/pubmed/21118971
trait: Small-cell lung cancer (survival)
initial_samplesize: 245 Han Chinese ancestry cases
replication_samplesize: 305 Han Chinese ancestry cases
region: 11q22.3
chrom: 11
reported_genes: DYNC2H1
mapped_gene: MTND1P36 - MIR4693
upstream_gene_id: 100506721
downstream_gene_id: 100616457
strongest_risk_snp: rs716274
strongest_risk_allele: G
snps: rs716274
snp_id_current: 716274
context: Intergenic
pvalue_mlog: 7.045757490560674
ci_95: [1.47-2.29] (AG)
platform: Affymetrix [265,996]
cnv: N
study:
Genome-wide interrogation identifies YAP1 variants associated with survival of small-cell lung cancer patients.


dbdate: 2011-01-08
author: van der Zanden LF
date: 2010-11-28
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21113153
study: Common variants in DGKK are strongly associated with risk of hypospadias.
trait: Hypospadias
initial_samplesize: 436 European ancestry cases, 494 European ancestry controls
region: Xp11.22
chrom: 23
reported_genes: DGKK
mapped_gene: DGKK
snp_gene_ids: 139189
strongest_risk_snp: rs1934179
strongest_risk_allele: A
snps: rs1934179
snp_id_current: 1934179
context: intron
pvalue_mlog: 20.52287874528034
ci_95: [2.1-3.1]
platform: Affymetrix [574,400] (pooled)
cnv: N
replication_samplesize:
133 European ancestry cases and their parents, 266 European ancestry cases, 402 European ancestry controls


dbdate: 2011-01-08
author: McClay JL
date: 2010-11-24
journal: Neuropsychopharmacology
link: http://www.ncbi.nlm.nih.gov/pubmed/21107309
trait: Response to antipsychotic treatment
initial_samplesize: 738 European ancestry, African-American, and other ancestry cases
region: 11p13
chrom: 11
reported_genes: EHF
mapped_gene: EHF
snp_gene_ids: 26298
strongest_risk_snp: rs286913
snps: rs286913
snp_id_current: 286913
context: intron
pvalue_mlog: 7.154901959985742
platform: Affymetrix [492,900]
cnv: N
study:
Genome-wide pharmacogenomic study of neurocognition as an indicator of antipsychotic treatment response in schizophrenia.


dbdate: 2014-07-01
author: Elks CE
date: 2010-11-21
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21102462
trait: Menarche (age at onset)
initial_samplesize: 86,142 European ancestry women, 557 Old Order Amish women, 1,103 Erasmus Rucphen women
region: 6q16.3
chrom: 6
reported_genes: LIN28B
mapped_gene: HACE1 - LINC00577
upstream_gene_id: 57531
downstream_gene_id: 100113403
strongest_risk_snp: rs7759938
strongest_risk_allele: C
snps: rs7759938
snp_id_current: 7759938
context: Intergenic
pvalue_mlog: 59.30102999566398
ci_95: [5.62-7.18] week increase
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Thirty new loci for age at menarche identified by a meta-analysis of genome-wide association studies.

replication_samplesize:
Up to 12,813 European ancestry women, 910 Val Borbera women, 348 Orcadian women, 338 Friuli Venezia Giulia women, 322 Carlantino women


dbdate: 2012-10-19
author: Franke A
date: 2010-11-21
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21102463
trait: Crohn's disease
initial_samplesize: 6,333 European ancestry cases, 15,056 European ancestry controls
region: 10q21.2
chrom: 10
reported_genes: ZNF365
mapped_gene: ZNF365 - ALDH7A1P4
upstream_gene_id: 22891
downstream_gene_id: 544
strongest_risk_snp: rs10761659
strongest_risk_allele: G
snps: rs10761659
snp_id_current: 10761659
context: Intergenic
pvalue_mlog: 21.39794000867203
ci_95: [1.18-1.29]
platform: Affymetrix & Illumina [953,241] (imputed)
cnv: N
study:
Genome-wide meta-analysis increases to 71 the number of confirmed Crohn's disease susceptibility loci.

replication_samplesize:
15,694 European ancestry cases, 14,026 European ancestry controls, 414 European ancestry parent-offspring trios


dbdate: 2011-01-07
author: Li YJ
date: 2010-11-20
journal: Ophthalmology
link: http://www.ncbi.nlm.nih.gov/pubmed/21095009
trait: Myopia (pathological)
replication_samplesize: 959 Japanese ancestry cases, 2,128 Japanese ancestry controls
region: 5p15.2
chrom: 5
reported_genes: CTNND2
mapped_gene: CTNND2
snp_gene_ids: 1501
strongest_risk_snp: rs6885224
strongest_risk_allele: C
snps: rs6885224
snp_id_current: 6885224
context: intron
pvalue_mlog: 5.096910013008055
ci_95: [1.11-1.39]
platform: Illumina [459,687]
cnv: N
study:
Genome-wide association studies reveal genetic variants in CTNND2 for high myopia in Singapore Chinese.

initial_samplesize:
65 Singaporean Chinese child cases, 238 Singaporean Chinese child controls, 222 Singaporean Chinese adult cases, 455 Singaporean Chinese adult cases


dbdate: 2011-01-06
author: Erdmann J
date: 2010-11-18
journal: Eur Heart J
link: http://www.ncbi.nlm.nih.gov/pubmed/21088011
trait: Coronary heart disease
initial_samplesize: 1,157 European ancestry cases, 1,748 European ancestry controls
replication_samplesize: 7,887 European ancestry cases, 8,244 European ancestry controls
region: 10p11.23
chrom: 10
reported_genes: KIAA1462
mapped_gene: KIAA1462
snp_gene_ids: 57608
strongest_risk_snp: rs3739998
strongest_risk_allele: C
snps: rs3739998
snp_id_current: 3739998
context: missense
pvalue_mlog: 11
ci_95: [1.11-1.20]
platform: Affymetrix [254,558]
cnv: N
study:
Genome-wide association study identifies a new locus for coronary artery disease on chromosome 10p11.23.


dbdate: 2014-06-24
author: Marzi C
date: 2010-11-18
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21124955
trait: Amyloid A serum levels
initial_samplesize: 3,329 European ancestry individuals, 882 Sorbian individuals
replication_samplesize: 2,136 European ancestry individuals
region: 11p15.1
chrom: 11
reported_genes: SAA1
mapped_gene: ST13P5 - SAA1
upstream_gene_id: 144106
downstream_gene_id: 6288
strongest_risk_snp: rs4638289
strongest_risk_allele: A
snps: rs4638289
snp_id_current: 4638289
context: Intergenic
pvalue_mlog: 52.52287874528033
ci_95: [0.27-0.35] unit increase
platform: Affymetrix & Illumina [2,593,456] (imputed)
cnv: N
study:
Genome-wide association study identifies two novel regions at 11p15.5-p13 and 1p31 with major impact on acute-phase serum amyloid A.


dbdate: 2011-01-12
author: Paternoster L
date: 2010-11-18
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21124946
trait: Bone mineral density
initial_samplesize: 1,934 European ancestry individuals
replication_samplesize: Up to 3,835 European ancestry individuals
region: 13q14.11
chrom: 13
reported_genes: RANKL
mapped_gene: FABP3P2 - TNFSF11
upstream_gene_id: 56677
downstream_gene_id: 8600
strongest_risk_snp: rs1021188
strongest_risk_allele: C
snps: rs1021188
snp_id_current: 1021188
context: Intergenic
pvalue_mlog: 13.69897000433602
ci_95: [1.91-5.87] mg/cm3 decrease
platform: Illumina [2,417,199] (imputed)
cnv: N
study:
Genome-wide association meta-analysis of cortical bone mineral density unravels allelic heterogeneity at the RANKL locus and potential pleiotropic effects on bone.


dbdate: 2011-01-06
author: Saad M
date: 2010-11-17
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21084426
trait: Parkinson's disease
initial_samplesize: 1,039 European ancestry cases, 1,984 European ancestry controls
replication_samplesize: 3,232 European ancestry cases, 7,064 European ancestry controls
region: 4p15.32
chrom: 4
reported_genes: BST1
mapped_gene: BST1
snp_gene_ids: 683
strongest_risk_snp: rs4698412
strongest_risk_allele: A
snps: rs4698412
snp_id_current: 4698412
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [1.08-1.20]
platform: Illumina [492,929]
cnv: N
study:
Genome-wide association study confirms BST1 and suggests a locus on 12q24 as the risk loci for Parkinson's disease in the European population.


dbdate: 2010-12-09
author: Sato Y
date: 2010-11-12
journal: J Thorac Oncol
link: http://www.ncbi.nlm.nih.gov/pubmed/21079520
trait: Non-small cell lung cancer (survival)
initial_samplesize: 105 East Asian ancestry cases
region: 2q37.1
chrom: 2
reported_genes: EIF4E2
mapped_gene: EIF4E2
snp_gene_ids: 9470
strongest_risk_snp: rs1656402
snps: rs1656402
snp_id_current: 1656402
context: intron
pvalue_mlog: 7.096910013008055
ci_95: [1.49-3.85] (AG)
platform: Illumina [109,365]
cnv: N
study:
Genome-wide association study on overall survival of advanced non-small cell lung cancer patients treated with carboplatin and paclitaxel.


dbdate: 2011-01-06
author: Evangelou E
date: 2010-11-10
journal: Ann Rheum Dis
link: http://www.ncbi.nlm.nih.gov/pubmed/21068099
trait: Osteoarthritis
initial_samplesize: 2,371 European ancestry cases, 35,909 European ancestry controls
region: 7q22.3
chrom: 7
reported_genes: DUS4L
mapped_gene: DUS4L
snp_gene_ids: 11062
strongest_risk_snp: rs4730250
strongest_risk_allele: G
snps: rs4730250
snp_id_current: 4730250
context: intron
pvalue_mlog: 7.221848749616355
ci_95: [1.10-1.22]
platform: Affymetrix & Illumina [2,335,627] (imputed)
cnv: N
study:
Meta-analysis of genome-wide association studies confirms a susceptibility locus for knee osteoarthritis on chromosome 7q22.

replication_samplesize:
4,338 European ancestry cases, 8,530 European ancestry controls, 1,183 East Asian ancestry cases, 1,245 East Asian ancestry controls


dbdate: 2011-01-14
author: Shen H
date: 2010-11-08
journal: Arch Intern Med
link: http://www.ncbi.nlm.nih.gov/pubmed/21059979
trait: LDL cholesterol
initial_samplesize: 841 Amish individuals
replication_samplesize: 663 Amish inidividuals
region: 2p24.1
chrom: 2
reported_genes: APOB
mapped_gene: C2orf43
snp_gene_ids: 60526
strongest_risk_snp: rs4971516
snps: rs4971516
snp_id_current: 4971516
context: intron
pvalue_mlog: 39.69897000433601
platform: Affymetrix [369,241]
cnv: N
study:
Familial defective apolipoprotein B-100 and increased low-density lipoprotein cholesterol and coronary artery calcification in the old order amish.


dbdate: 2011-08-02
author: Agrawal A
date: 2010-11-04
journal: Addict Biol
link: http://www.ncbi.nlm.nih.gov/pubmed/21668797
study: A genome-wide association study of DSM-IV cannabis dependence.
trait: Cannabis dependence
region: 1q31.2
chrom: 1
reported_genes: UCHL5
mapped_gene: UCHL5
snp_gene_ids: 51377
strongest_risk_snp: rs9427573
snps: rs9427573
snp_id_current: 9427573
context: intron
pvalue_mlog: 5.301029995663981
ci_95: [1.71-3.82]
platform: Illumina [948,142]
cnv: N
initial_samplesize:
708 African American or European ancestry cases, 2,346 African American or European ancestry controls


dbdate: 2011-01-11
author: Curtis D
date: 2010-11-04
journal: Psychiatr Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21057379
trait: Bipolar disorder and schizophrenia
region: 17q24.2
chrom: 17
reported_genes: CACNG5
mapped_gene: CACNG5 - CACNG4
upstream_gene_id: 27091
downstream_gene_id: 27092
strongest_risk_snp: rs17645023
snps: rs17645023
snp_id_current: 17645023
context: Intergenic
pvalue_mlog: 6.221848749616355
platform: Affymetrix [302,482]
cnv: N
study:
Case-case genome-wide association analysis shows markers differentially associated with schizophrenia and bipolar disorder and implicates calcium channel genes.

initial_samplesize:
506 European ancestry bipolar 1 disorder cases, 523 European ancestry schizophrenia cases, 505 European ancestry controls


dbdate: 2011-01-13
author: Pereyra F
date: 2010-11-04
journal: Science
link: http://www.ncbi.nlm.nih.gov/pubmed/21051598
study: The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.
trait: HIV-1 control
region: 6p21.33
chrom: 6
reported_genes: MICA
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs4418214
strongest_risk_allele: C
snps: rs4418214
snp_id_current: 4418214
pvalue_mlog: 34
ci_95: [NR]
platform: Illumina [1,384,048] (imputed)
cnv: N
initial_samplesize:
516 European cases, 1,196 European controls, 341 African American cases, 892 African American controls, 117 Hispanic ancestry controls, 560 Hispanic ancestry controls


dbdate: 2011-01-03
author: Spencer CC
date: 2010-11-02
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21044948
trait: Parkinson's disease
initial_samplesize: 1,705 European ancestry cases, 5,175 European ancestry controls
replication_samplesize: 1,039 European ancestry cases, 1,984 European ancestry controls
region: 3p24.1
chrom: 3
mapped_gene: LINC00693
snp_gene_ids: 645206
strongest_risk_snp: rs7617877
strongest_risk_allele: A
snps: rs7617877
snp_id_current: 7617877
context: intron
pvalue_mlog: 5.522878745280337
ci_95: [1.13-1.33]
platform: Illumina [532,616]
cnv: N
study:
Dissection of the genetics of Parkinson's disease identifies an additional association 5' of SNCA and multiple associated haplotypes at 17q21.


dbdate: 2011-01-04
author: Wray NR
date: 2010-11-02
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/21042317
trait: Major depressive disorder
initial_samplesize: 2,431 European ancestry cases, 3,673 European ancestry controls
replication_samplesize: 3,332 European ancestry cases, 3,228 European ancestry controls
region: 1q42.11
chrom: 1
reported_genes: CNIH4,NVL,WDR26
mapped_gene: MIR320B2 - CNIH4
upstream_gene_id: 100313769
downstream_gene_id: 29097
strongest_risk_snp: rs11579964
strongest_risk_allele: C
snps: rs11579964
snp_id_current: 11579964
context: Intergenic
pvalue_mlog: 5.397940008672037
ci_95: [NR]
platform: Affymetrix & Illumina [1,251,157] (imputed)
cnv: N
study:
Genome-wide association study of major depressive disorder: new results, meta-analysis, and lessons learned.


dbdate: 2011-01-03
author: Yang J
date: 2010-11-02
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21044949
study: ELF1 is associated with systemic lupus erythematosus in Asian populations.
trait: Systemic lupus erythematosus
initial_samplesize: 612 Chinese ancestry cases, 1,160 Chinese ancestry controls
region: 13q14.11
chrom: 13
reported_genes: ELF1
mapped_gene: ELF1
snp_gene_ids: 1997
strongest_risk_snp: rs7329174
strongest_risk_allele: G
snps: rs7329174
snp_id_current: 7329174
context: intron
pvalue_mlog: 8
ci_95: [1.16-1.36]
platform: Illumina [513,108]
cnv: N
replication_samplesize:
2,090 Chinese ancestry cases, 1,981 Chinese ancestry controls, 462 Thai ancestry cases, 951 Thai ancestry controls


dbdate: 2011-01-03
author: Zlojutro M
date: 2010-11-02
journal: Am J Med Genet B Neuropsychiatr Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21184583
trait: Event-related brain oscillations
replication_samplesize: 683 alcohol dependence cases and 412 controls from multiplex families
region: 2q11.2
chrom: 2
reported_genes: ARID5A
mapped_gene: ARID5A - KANSL3
upstream_gene_id: 10865
downstream_gene_id: 55683
strongest_risk_snp: rs4907240
strongest_risk_allele: A
snps: rs4907240
snp_id_current: 4907240
context: Intergenic
pvalue_mlog: 5.397940008672037
ci_95: [0.14-0.36] uV increase
platform: Illumina [951,071]
cnv: N
study:
Genome-wide association study of theta band event-related oscillations identifies serotonin receptor gene HTR7 influencing risk of alcohol dependence.

initial_samplesize:
431 European ancestry alcohol dependence cases, 340 European ancestry controls, 209 African American alcohol dependence cases, 84 African American controls


dbdate: 2011-01-03
author: Denny JC
date: 2010-11-01
journal: Circulation
link: http://www.ncbi.nlm.nih.gov/pubmed/21041692
trait: Atrioventricular conduction
initial_samplesize: 2,334 European ancestry individuals
region: 3p22.2
chrom: 3
reported_genes: SCN10A
mapped_gene: SCN10A
snp_gene_ids: 6336
strongest_risk_snp: rs6800541
strongest_risk_allele: C
snps: rs6800541
snp_id_current: 6800541
context: intron
pvalue_mlog: 6.30102999566398
ci_95: [1.62-3.70] ms increase
platform: Illumina [514,999]
cnv: N
study:
Identification of genomic predictors of atrioventricular conduction: using electronic medical records as a tool for genome science.


dbdate: 2013-08-20
author: Haritunians T
date: 2010-11-01
journal: Inflamm Bowel Dis
link: http://www.ncbi.nlm.nih.gov/pubmed/20848476
study: Genetic predictors of medically refractory ulcerative colitis.
trait: Ulcerative colitis
region: 4q34.3
chrom: 4
reported_genes: Intergenic
mapped_gene: RNA5SP173 - LINC00290
upstream_gene_id: 100873437
downstream_gene_id: 728081
strongest_risk_snp: rs6811556
strongest_risk_allele: A
snps: rs6811556
snp_id_current: 6811556
context: Intergenic
pvalue_mlog: 5.045757490560675
platform: Illumina [313,720]
cnv: N
initial_samplesize:
324 European ancestry medically refractory ulcerative colitis cases, 537 European ancestry non-medically refractory ulcerative colitis cases, 2,601 European ancestry controls


dbdate: 2014-01-07
author: Perlis RH
date: 2010-11-01
journal: Am J Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/21041247
study: Genome-wide association study of suicide attempts in mood disorder patients.
trait: Suicide risk
replication_samplesize: 2,698 European ancestry Bipolar disorder cases, 1,649 Major depressive disorder cases
region: 10q24.1
chrom: 10
reported_genes: SORBS1, PDLIM1
mapped_gene: SORBS1
snp_gene_ids: 10580
strongest_risk_snp: rs4918918
strongest_risk_allele: T
snps: rs4918918
snp_id_current: 4918918
context: intron
pvalue_mlog: 5.522878745280337
platform: Affymetrix [1,922,309] (Imputed)
cnv: N
initial_samplesize:
3,117 European ancestry Bipolar disorder cases, 1,273 European ancestry Major depressive disorder cases


dbdate: 2011-01-03
author: Enciso-Mora V
date: 2010-10-31
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21037568
trait: Hodgkin's lymphoma
initial_samplesize: 589 European ancestry cases, 5,199 European ancestry controls
replication_samplesize: 2,057 European ancestry cases, 3,416 European ancestry controls
region: 2p16.1
chrom: 2
reported_genes: REL
mapped_gene: PAPOLG - LINC01185
upstream_gene_id: 64895
downstream_gene_id: 400957
strongest_risk_snp: rs1432295
strongest_risk_allele: G
snps: rs1432295
snp_id_current: 1432295
context: Intergenic
pvalue_mlog: 7.698970004336018
ci_95: [1.14-1.30]
platform: Illumina [504,374]
cnv: N
study:
A genome-wide association study of Hodgkin's lymphoma identifies new susceptibility loci at 2p16.1 (REL), 8q24.21 and 10p14 (GATA3).


dbdate: 2010-12-16
author: Padmanabhan S
date: 2010-10-28
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21082022
trait: Hypertension
initial_samplesize: 1,621 extreme cases, 1,699 controls
replication_samplesize: 19,845 extreme cases, 16,541 controls
region: 16p12.3
chrom: 16
reported_genes: UMOD
mapped_gene: UMOD
snp_gene_ids: 7369
strongest_risk_snp: rs13333226
strongest_risk_allele: A
snps: rs13333226
snp_id_current: 13333226
context: nearGene-5
pvalue_mlog: 10.39794000867204
ci_95: [1.10-1.19]
platform: Illumina [521,220] (imputed)
cnv: N
study:
Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension.


dbdate: 2010-12-09
author: Houlston RS
date: 2010-10-24
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20972440
trait: Colorectal cancer
initial_samplesize: 3,334 European ancestry cases, 4,628 European ancestry controls
replication_samplesize: 14,851 European ancestry cases, 15,569 European ancestry controls
region: 1q41
chrom: 1
reported_genes: DUSP10
mapped_gene: DUSP10 - QRSL1P2
upstream_gene_id: 11221
downstream_gene_id: 100422330
strongest_risk_snp: rs6691170
strongest_risk_allele: T
snps: rs6691170
snp_id_current: 6691170
context: Intergenic
pvalue_mlog: 8.999999999999998
ci_95: [1.03-1.09]
platform: Illumina [up to ~550,000] (imputed)
cnv: N
study:
Meta-analysis of three genome-wide association studies identifies susceptibility loci for colorectal cancer at 1q41, 3q26.2, 12q13.13 and 20q13.33.


dbdate: 2010-12-08
author: Rothman N
date: 2010-10-24
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20972438
trait: Bladder cancer
initial_samplesize: 3,532 European ancestry cases, 5,120 European ancestry controls
replication_samplesize: 8,381 cases, 48,275 controls
region: 22q13.1
chrom: 22
reported_genes: CBX6,APOBEC3A
mapped_gene: CBX6 - APOBEC3A
upstream_gene_id: 23466
downstream_gene_id: 200315
strongest_risk_snp: rs1014971
snps: rs1014971
snp_id_current: 1014971
context: Intergenic
pvalue_mlog: 11.09691001300806
ci_95: [1.10-1.18]
platform: Illumina [589,299]
cnv: N
study:
A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci.


dbdate: 2010-12-03
author: Croteau-Chonka DC
date: 2010-10-21
journal: Obesity (Silver Spring)
link: http://www.ncbi.nlm.nih.gov/pubmed/20966902
trait: Body mass index
initial_samplesize: 1,780 Filipino ancestry women
region: 1p31.3
chrom: 1
reported_genes: ATG4C
mapped_gene: ATG4C - LINC00466
upstream_gene_id: 84938
downstream_gene_id: 199899
strongest_risk_snp: rs17124318
strongest_risk_allele: C
snps: rs17124318
snp_id_current: 17124318
context: Intergenic
pvalue_mlog: 6.221848749616355
ci_95: [0.04-0.10] unit increase
platform: Affymetrix [2,073,674] (imputed)
cnv: N
study:
Genome-wide association study of anthropometric traits and evidence of interactions with age and study year in Filipino women.


dbdate: 2010-12-01
author: Ellinghaus E
date: 2010-10-17
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20953188
study: Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.
trait: Psoriasis
initial_samplesize: 472 European ancestry cases, 1,146 European ancestry controls
region: 5q33.3
chrom: 5
reported_genes: IL12B
mapped_gene: LOC285626
snp_gene_ids: 285626
strongest_risk_snp: rs2546890
strongest_risk_allele: A
snps: rs2546890
snp_id_current: 2546890
context: ncRNA
pvalue_mlog: 20
ci_95: [1.32-1.79]
platform: Illumina [2,339,118] (imputed)
cnv: N
replication_samplesize:
2,668, European ancestry cases, 762 French Canadian founder population cases, 2,585 cases, 3,485 European ancestry controls, 994 French Canadian founder population controls, 2,412 controls


dbdate: 2010-11-30
author: Huffmeier U
date: 2010-10-17
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20953186
trait: Psoriatic arthritis
initial_samplesize: 572 European ancestry cases, 888 European ancestry controls
replication_samplesize: Up to 1,761 European ancestry cases, 3,727 European ancestry controls
region: 6p21.33
chrom: 6
reported_genes: HLA-C
mapped_gene: HLA-C
snp_gene_ids: 3107
strongest_risk_snp: rs13191343
strongest_risk_allele: T
snps: rs13191343
snp_id_current: 13191343
context: nearGene-5
pvalue_mlog: 71.698970004336
ci_95: [2.16-2.61]
platform: Affymetrix [1,585,307] (imputed)
cnv: N
study:
Common variants at TRAF3IP2 are associated with susceptibility to psoriatic arthritis and psoriasis.


dbdate: 2011-01-18
author: Strange A
date: 2010-10-17
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20953190
trait: Psoriasis
initial_samplesize: 2,178 European ancestry cases, 5,175 European ancestry controls
replication_samplesize: 3,174 European ancestry cases, 5,464 European ancestry controls
region: 1p36.11
chrom: 1
reported_genes: IL28RA
mapped_gene: IFNLR1 - GRHL3
upstream_gene_id: 163702
downstream_gene_id: 57822
strongest_risk_snp: rs4649203
strongest_risk_allele: A
snps: rs4649203
snp_id_current: 4649203
context: Intergenic
pvalue_mlog: 7.154901959985742
ci_95: [1.05-1.22]
platform: Illumina [535,475]
cnv: N
study:
A genome-wide association study identifies new psoriasis susceptibility loci and an interaction between HLA-C and ERAP1.


dbdate: 2010-11-17
author: Heid IM
date: 2010-10-10
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20935629
trait: Waist-hip ratio
initial_samplesize: Up to 77,167 European ancestry individuals
replication_samplesize: Up to 113,636 European ancestry individuals
region: 7p15.2
chrom: 7
reported_genes: NFE2L3
mapped_gene: LOC100506236
snp_gene_ids: 100506236
strongest_risk_snp: rs1055144
strongest_risk_allele: T
snps: rs1055144
snp_id_current: 1055144
context: ncRNA
pvalue_mlog: 24
ci_95: [NR] unit increase
platform: Affymetrix, Illumina & Perlegen [up to 2,850,269](imputed)
cnv: N
study:
Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution.


dbdate: 2010-11-23
author: Han MR
date: 2010-10-08
journal: BMC Neurol
link: http://www.ncbi.nlm.nih.gov/pubmed/20932310
trait: Cerebrospinal AB1-42 levels
region: 15q21.2
chrom: 15
reported_genes: CYP19A1
mapped_gene: CYP19A1
snp_gene_ids: 1588
strongest_risk_snp: rs2899472
strongest_risk_allele: A
snps: rs2899472
snp_id_current: 2899472
context: intron
pvalue_mlog: 8.698970004336019
platform: Illumina [498,205]
cnv: N
study:
Genome-wide association reveals genetic effects on human A&#x003b2;42 and &#x003c4; protein levels in cerebrospinal fluids: a case control study.

initial_samplesize:
172 European ancestry Alzheimer's disease cases, 109 European ancestry mild cognitive impairment cases, 109 European ancestry controls


dbdate: 2010-11-15
author: Kerns SL
date: 2010-10-05
journal: Int J Radiat Oncol Biol Phys
link: http://www.ncbi.nlm.nih.gov/pubmed/20932654
trait: Erectile dysfunction and prostate cancer treatment
initial_samplesize: 27 African American cases, 52 African American controls
region: 2p16.3
chrom: 2
reported_genes: FSHR
mapped_gene: FSHR
snp_gene_ids: 2492
strongest_risk_snp: rs2268363
snps: rs2268363
snp_id_current: 2268363
context: intron
pvalue_mlog: 7.30102999566398
ci_95: [NR]
platform: Affymetrix [512,497]
cnv: N
study:
Genome-wide association study to identify single nucleotide polymorphisms (SNPs) associated with the development of erectile dysfunction in African-American men after radiotherapy for prostate cancer.


dbdate: 2010-11-23
author: Niu N
date: 2010-10-05
journal: Genome Res
link: http://www.ncbi.nlm.nih.gov/pubmed/20923822
trait: Radiation response
region: 8q22.1
chrom: 8
reported_genes: PLEKHF2
mapped_gene: MIR3150A - PLEKHF2
upstream_gene_id: 100422964
downstream_gene_id: 79666
strongest_risk_snp: rs7000734
snps: rs7000734
snp_id_current: 7000734
context: Intergenic
pvalue_mlog: 6.397940008672037
platform: Affymetrix & Illumina [1,348,798]
cnv: N
study:
Radiation pharmacogenomics: a genome-wide association approach to identify radiation response biomarkers using human lymphoblastoid cell lines.

initial_samplesize:
Human lymphoblastoid cell lines; 93 of African American, 89 of European ancestry, and 95 of Han Chinese American ancestry


dbdate: 2011-01-14
author: Shatunov A
date: 2010-10-01
journal: Lancet Neurol
link: http://www.ncbi.nlm.nih.gov/pubmed/20801717
trait: Amyotrophic lateral sclerosis
initial_samplesize: 4,857 European ancestry cases, 8,987 European ancestry controls
region: 11q14.3
chrom: 11
mapped_gene: NOX4 - FOLH1B
upstream_gene_id: 50507
downstream_gene_id: 219595
strongest_risk_snp: rs1488902
strongest_risk_allele: C
snps: rs1488902
snp_id_current: 1488902
context: Intergenic
pvalue_mlog: 5.522878745280337
ci_95: [NR]
platform: Illumina [227,475]
cnv: N
study:
Chromosome 9p21 in sporadic amyotrophic lateral sclerosis in the UK and seven other countries: a genome-wide association study.


dbdate: 2012-11-02
author: Wang KS
date: 2010-10-01
journal: Schizophr Res
link: http://www.ncbi.nlm.nih.gov/pubmed/20889312
trait: Bipolar disorder and schizophrenia
region: 5q22.2
chrom: 5
mapped_gene: MCC
snp_gene_ids: 4163
strongest_risk_snp: rs17323670
snps: rs17323670
snp_id_current: 17323670
context: intron
pvalue_mlog: 5.154901959985742
ci_95: [NR]
platform: Affymetrix [722,112]
cnv: N
study:
A genome-wide meta-analysis identifies novel loci associated with schizophrenia and bipolar disorder.

initial_samplesize:
651 European ancestry bipolar cases, 1,171 European ancestry schizophrenia cases, 2,412 European ancestry controls


dbdate: 2010-10-15
author: Yang Q
date: 2010-09-30
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20884846
trait: Urate levels
initial_samplesize: 28,283 European ancestry individuals
replication_samplesize: 22,054 European ancestry individuals
region: 4p16.1
chrom: 4
reported_genes: SLC2A9
mapped_gene: SLC2A9
snp_gene_ids: 56606
strongest_risk_snp: rs13129697
strongest_risk_allele: G
snps: rs13129697
snp_id_current: 13129697
context: intron
pvalue_mlog: 241.698970004336
ci_95: [20.90-23.52] umol/l decrease
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors.


dbdate: 2010-10-15
author: Perroud N
date: 2010-09-28
journal: Pharmacogenomics J
link: http://www.ncbi.nlm.nih.gov/pubmed/20877300
trait: Suicidal ideation
initial_samplesize: 706 European ancestry individuals
region: 9q21.13
chrom: 9
reported_genes: GDA
mapped_gene: GDA - RNA5SP285
upstream_gene_id: 9615
downstream_gene_id: 100873538
strongest_risk_snp: rs11143230
strongest_risk_allele: C
snps: rs11143230
snp_id_current: 11143230
context: Intergenic
pvalue_mlog: 6.096910013008056
ci_95: [NR]
platform: Illumina [539,199]
cnv: N
study:
Genome-wide association study of increasing suicidal ideation during antidepressant treatment in the GENDEP project.


dbdate: 2010-10-15
author: Yoon KA
date: 2010-09-28
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20876614
trait: Non-small cell lung cancer
initial_samplesize: 621 Korean ancestry cases, 1,541 Korean ancestry controls
replication_samplesize: 804 Korean ancestry cases, 1,470 Korean ancestry controls
region: 17p13.2
chrom: 17
mapped_gene: NLRP1 - WSCD1
upstream_gene_id: 22861
downstream_gene_id: 23302
strongest_risk_snp: rs9303196
strongest_risk_allele: T
snps: rs9303196
snp_id_current: 9303196
context: Intergenic
pvalue_mlog: 5.096910013008055
ci_95: [1.14-1.82]
platform: Affymetrix [246,758]
cnv: N
study:
A genome-wide association study reveals susceptibility variants for non-small cell lung cancer in the Korean population.


dbdate: 2010-10-15
author: Ingle JN
date: 2010-09-27
journal: J Clin Oncol
link: http://www.ncbi.nlm.nih.gov/pubmed/20876420
trait: Adverse response to aromatase inhibitors
initial_samplesize: 293 cases, 585 controls
region: 14q32.13
chrom: 14
reported_genes: TCL1A
mapped_gene: TCL1B - TCL1A
upstream_gene_id: 9623
downstream_gene_id: 8115
strongest_risk_snp: rs7158782
snps: rs7158782
snp_id_current: 7158782
context: Intergenic
pvalue_mlog: 6.096910013008056
ci_95: [1.58-2.87]
platform: Illumina [551,395]
cnv: N
study:
Genome-wide associations and functional genomic studies of musculoskeletal adverse events in women receiving aromatase inhibitors.


dbdate: 2010-10-07
author: Wu Y
date: 2010-09-27
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20876611
trait: Adiponectin levels
initial_samplesize: 1,776 Filipino ancestry women
replication_samplesize: 1,774 independent Filipino ancestry offspring
region: 16q23.3
chrom: 16
reported_genes: CDH13
mapped_gene: MPHOSPH6 - CDH13
upstream_gene_id: 10200
downstream_gene_id: 1012
strongest_risk_snp: rs3865188
strongest_risk_allele: T
snps: rs3865188
snp_id_current: 3865188
context: Intergenic
pvalue_mlog: 29.39794000867203
ci_95: [0.09-0.13] unit decrease
platform: Affymetrix [2,073,674] (imputed)
cnv: N
study:
Genome-wide association study for adiponectin levels in Filipino women identifies CDH13 and a novel uncommon haplotype at KNG1-ADIPOQ.


dbdate: 2010-10-07
author: Miki D
date: 2010-09-26
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20871597
trait: Lung adenocarcinoma
initial_samplesize: 1,004 Japanese ancestry cases, 1,900 Japanese ancestry controls
replication_samplesize: 1,094 East Asian ancestry cases, 9,148 East Asian ancestry controls
region: 3q28
chrom: 3
reported_genes: TP63
mapped_gene: TP63
snp_gene_ids: 8626
strongest_risk_snp: rs10937405
strongest_risk_allele: C
snps: rs10937405
snp_id_current: 10937405
context: intron
pvalue_mlog: 11.15490195998574
ci_95: [1.22-1.42]
platform: Illumina [432,024]
cnv: N
study:
Variation in TP63 is associated with lung adenocarcinoma susceptibility in Japanese and Korean populations.


dbdate: 2010-10-14
author: Kopplin LJ
date: 2010-09-23
journal: Genes Immun
link: http://www.ncbi.nlm.nih.gov/pubmed/20861866
trait: Age-related macular degeneration
initial_samplesize: 684 European ancestry cases, 188 European ancestry controls
replication_samplesize: 1,896 European ancestry cases, 1,866 European ancestry controls
region: 1q31.3
chrom: 1
reported_genes: CFH
mapped_gene: CFH
snp_gene_ids: 3075
strongest_risk_snp: rs1329428
snps: rs1329428
snp_id_current: 1329428
context: intron
pvalue_mlog: 63.52287874528032
ci_95: [NR]
platform: Affymetrix [>361,556] (imputed)
cnv: N
study:
Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration.


dbdate: 2010-10-14
author: Naj AC
date: 2010-09-23
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20885792
trait: Alzheimer's disease (late onset)
initial_samplesize: 931 cases, 1,104 controls
replication_samplesize: 1,338 cases, 2,003 controls
region: 19q13.32
chrom: 19
reported_genes: APOE,TOMM40
mapped_gene: TOMM40
snp_gene_ids: 10452
strongest_risk_snp: rs2075650
strongest_risk_allele: G
snps: rs2075650
snp_id_current: 2075650
context: intron
pvalue_mlog: 35.30102999566397
ci_95: [2.48-3.47]
platform: Illumina [483,399]
cnv: N
study:
Dementia revealed: novel chromosome 6 locus for late-onset Alzheimer disease provides genetic evidence for folate-pathway abnormalities.


dbdate: 2010-10-07
author: Soranzo N
date: 2010-09-21
journal: Diabetes
link: http://www.ncbi.nlm.nih.gov/pubmed/20858683
trait: Glycated hemoglobin levels
initial_samplesize: up to 46,368 European ancestry individuals
region: 1q23.1
chrom: 1
reported_genes: SPTA1
mapped_gene: SPTA1
snp_gene_ids: 6708
strongest_risk_snp: rs2779116
strongest_risk_allele: T
snps: rs2779116
snp_id_current: 2779116
context: intron
pvalue_mlog: 8.522878745280337
ci_95: [0.01-0.03] % increase
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Common variants at 10 genomic loci influence hemoglobin A&#x02081;(C) levels via glycemic and nonglycemic pathways.


dbdate: 2010-10-07
author: Antoniou AC
date: 2010-09-19
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20852631
trait: Breast cancer
initial_samplesize: 1,193 European ancestry cases, 1,190 European ancestry controls
replication_samplesize: 2,974 European ancestry cases, 3,012 European ancestry controls
region: 19p13.11
chrom: 19
reported_genes: ABHD8,ANKLE1,C19orf62
mapped_gene: BABAM1
snp_gene_ids: 29086
strongest_risk_snp: rs8170
strongest_risk_allele: A
snps: rs8170
snp_id_current: 8170
context: missense
pvalue_mlog: 8.698970004336019
ci_95: [1.17-1.35]
platform: Illumina [555,616]
cnv: N
study:
A locus on 19p13 modifies risk of breast cancer in BRCA1 mutation carriers and is associated with hormone receptor-negative breast cancer in the general population.


dbdate: 2010-10-06
author: Adachi S
date: 2010-09-16
journal: J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20844546
trait: Endometriosis
initial_samplesize: 696 Japanese ancestry cases, 825 Japanese ancestry controls
region: 1q42.13
chrom: 1
reported_genes: RHOU
mapped_gene: FTH1P2 - ISCA1P2
upstream_gene_id: 2497
downstream_gene_id: 100288517
strongest_risk_snp: rs801112
strongest_risk_allele: C
snps: rs801112
snp_id_current: 801112
context: Intergenic
pvalue_mlog: 5.301029995663981
ci_95: [1.33-2.05]
platform: Affymetrix [282,838]
cnv: N
study:
Meta-analysis of genome-wide association scans for genetic susceptibility to endometriosis in Japanese population.


dbdate: 2010-10-05
author: Franklin CS
date: 2010-09-16
journal: Ann Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20849430
trait: Glycated hemoglobin levels
initial_samplesize: 1,782 European ancestry individuals
region: 10q25.2
chrom: 10
reported_genes: TCF7L2
mapped_gene: TCF7L2
snp_gene_ids: 6934
strongest_risk_snp: rs7903146
strongest_risk_allele: C
snps: rs7903146
snp_id_current: 7903146
context: intron
pvalue_mlog: 7
ci_95: [0.02-0.08] % HbA1C decrease
platform: Illumina [256,587]
cnv: N
study:
The TCF7L2 diabetes risk variant is associated with HbA&#x02081;(C) levels: a genome-wide association meta-analysis.


dbdate: 2010-10-12
author: Shu XO
date: 2010-09-16
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20862305
study: Identification of new genetic risk variants for type 2 diabetes.
trait: Type 2 diabetes
initial_samplesize: 1,019 Chinese ancestry cases, 1,710 Chinese ancestry controls
region: 10p13
chrom: 10
reported_genes: CDC123,CAMK1D
mapped_gene: CDC123 - CAMK1D
upstream_gene_id: 8872
downstream_gene_id: 57118
strongest_risk_snp: rs10906115
strongest_risk_allele: A
snps: rs10906115
snp_id_current: 10906115
context: Intergenic
pvalue_mlog: 8
ci_95: [1.08-1.18]
platform: Affymetrix [590,887]
cnv: N
replication_samplesize:
2,591 European ancestry cases, 3,052 European ancestry controls, 6,184 East Asian cases, 9,853 East Asian controls


dbdate: 2010-10-05
author: Hysi PG
date: 2010-09-12
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20835236
trait: Refractive error
initial_samplesize: 4,270 European ancestry individuals
replication_samplesize: 13,414 European ancestry individuals
region: 15q25.1
chrom: 15
reported_genes: RASGRF1
mapped_gene: RASGRF1 - MIR184
upstream_gene_id: 5923
downstream_gene_id: 406960
strongest_risk_snp: rs939658
strongest_risk_allele: G
snps: rs939658
snp_id_current: 939658
context: Intergenic
pvalue_mlog: 8.698970004336019
ci_95: [0.10-0.20] diopter decrease
platform: Illumina [~2.2 million] (imputed)
cnv: N
study:
A genome-wide association study for myopia and refractive error identifies a susceptibility locus at 15q25.


dbdate: 2010-10-05
author: Solouki AM
date: 2010-09-12
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20835239
trait: Refractive error
initial_samplesize: 5,328 European ancestry individuals
replication_samplesize: 10,280 European ancestry individuals
region: 15q14
chrom: 15
reported_genes: GJD2,ACTC1,GOLGA8B
mapped_gene: MIR1233-2 - GJD2
upstream_gene_id: 100422845
downstream_gene_id: 57369
strongest_risk_snp: rs634990
strongest_risk_allele: C
snps: rs634990
snp_id_current: 634990
context: Intergenic
pvalue_mlog: 13.69897000433602
ci_95: [0.228-0.232] diopter increase
platform: Illumina [~2.5 million] (imputed)
cnv: N
study:
A genome-wide association study identifies a susceptibility locus for refractive errors and myopia at 15q14.


dbdate: 2010-10-05
author: Cha PC
date: 2010-09-10
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20833655
trait: Warfarin maintenance dose
initial_samplesize: 807 low dose Japanese ancestry individuals, 701 high dose Japanese ancestry individuals
replication_samplesize: 444 individuals
region: 19p13.12
chrom: 19
reported_genes: CYP4F2
mapped_gene: CYP4F2
snp_gene_ids: 8529
strongest_risk_snp: rs2108622
strongest_risk_allele: T
snps: rs2108622
snp_id_current: 2108622
context: missense
pvalue_mlog: 7.522878745280337
platform: Illumina [485,227]
cnv: N
study:
Genome-wide association study identifies genetic determinants of warfarin responsiveness for Japanese.


dbdate: 2010-09-28
author: Smith EN
date: 2010-09-09
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20838585
trait: Cardiovascular disease risk factors
initial_samplesize: 525 European ancestry individuals
replication_samplesize: 2,265 European ancestry individuals
region: 16q13
chrom: 16
reported_genes: CETP,HERPUD1
mapped_gene: HERPUD1 - CETP
upstream_gene_id: 9709
downstream_gene_id: 1071
strongest_risk_snp: rs247616
strongest_risk_allele: T
snps: rs247616
snp_id_current: 247616
context: Intergenic
pvalue_mlog: 23
ci_95: [2.42-3.56] % SD increase
platform: Illumina [545,821]
cnv: N
study:
Longitudinal genome-wide association of cardiovascular disease risk factors in the Bogalusa heart study.


dbdate: 2010-09-28
author: Yamauchi T
date: 2010-09-05
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20818381
trait: Type 2 diabetes
initial_samplesize: 4,470 Japanese ancestry cases, 3,071 Japanese ancestry controls
region: 15q22.2
chrom: 15
reported_genes: C2CD4A,C2CD4B
mapped_gene: NPM1P47 - C2CD4B
upstream_gene_id: 100129972
downstream_gene_id: 388125
strongest_risk_snp: rs7172432
snps: rs7172432
snp_id_current: 7172432
context: Intergenic
pvalue_mlog: 13.04575749056067
ci_95: [1.08-1.14]
platform: Illumina [459,359]
cnv: N
study:
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B.

replication_samplesize:
10,692 Japanese ancestry cases, 9,597 Japanese ancestry controls, 6,980 European ancestry cases, 8,615 European ancestry controls


dbdate: 2010-09-27
author: Baranzini SE
date: 2010-09-01
journal: Brain
link: http://www.ncbi.nlm.nih.gov/pubmed/20802204
trait: Multiple sclerosis--Brain Glutamate Levels
initial_samplesize: 382 cases
region: 3p26.1
chrom: 3
reported_genes: SUMF1
mapped_gene: SUMF1
snp_gene_ids: 285362
strongest_risk_snp: rs794185
snps: rs794185
snp_id_current: 794185
context: intron
pvalue_mlog: 6.221848749616355
platform: Illumina [~500,000]
cnv: N
study:
Genetic variation influences glutamate concentrations in brains of patients with multiple sclerosis.


dbdate: 2010-09-24
author: Uhl GR
date: 2010-08-24
journal: Mol Med
link: http://www.ncbi.nlm.nih.gov/pubmed/20811658
trait: Smoking cessation
initial_samplesize: 369 European ancestry individuals
region: 14q24.2
chrom: 14
reported_genes: RGS6
mapped_gene: RGS6
snp_gene_ids: 9628
strongest_risk_snp: rs7159300
snps: rs7159300
snp_id_current: 7159300
context: intron
pvalue_mlog: 5.397940008672037
platform: Affymetrix [905,273]
cnv: N
study:
Genome-wide association for smoking cessation success in a trial of precessation nicotine replacement.


dbdate: 2010-09-23
author: Abnet CC
date: 2010-08-22
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20729852
trait: Esophageal cancer and gastric cancer
region: 10q23.33
chrom: 10
reported_genes: PLCE1,NOC3L
mapped_gene: PLCE1
snp_gene_ids: 51196
strongest_risk_snp: rs3781264
strongest_risk_allele: C
snps: rs3781264
snp_id_current: 3781264
context: intron
pvalue_mlog: 8.397940008672036
ci_95: [1.23-1.50]
platform: Illumina [551,152]
cnv: N
study:
A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.

initial_samplesize:
1,625 Chinese ancestry gastric cancer cases, 1,898 Chinese ancestry ESCC cases, 2,100 Chinese ancestry controls


dbdate: 2010-09-22
author: Huang J
date: 2010-08-16
journal: Am J Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/20713499
study: Cross-disorder genomewide analysis of schizophrenia, bipolar disorder, and depression.
trait: Schizophrenia, bipolar disorder and depression (combined)
region: 11p15.4
chrom: 11
reported_genes: ADM
mapped_gene: CAND1.11
snp_gene_ids: 100130460
strongest_risk_snp: rs6484218
strongest_risk_allele: A
snps: rs6484218
snp_id_current: 6484218
context: intron
pvalue_mlog: 7.397940008672037
platform: Affymetrix & Perlegen [1,574,154] (imputed)
cnv: N
initial_samplesize:
402 European ancestry schizophrenia cases, 1,021 European ancestry bipolar I cases, 493 European ancestry bipolar II cases, 1,210 European ancestry MDD cases, 1,060 European ancestry controls


dbdate: 2010-09-22
author: Hamza TH
date: 2010-08-15
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20711177
trait: Parkinson's disease
initial_samplesize: 2,000 European ancestry cases, 1,986 European ancestry controls
replication_samplesize: Up to 1,447 cases, 1,468 controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DRA
mapped_gene: HLA-DRA
snp_gene_ids: 3122
strongest_risk_snp: rs3129882
strongest_risk_allele: G
snps: rs3129882
snp_id_current: 3129882
context: intron
pvalue_mlog: 9.698970004336017
ci_95: [1.17-1.35]
platform: Illumina [811,597]
cnv: N
study:
Common genetic variation in the HLA region is associated with late-onset sporadic Parkinson's disease.


dbdate: 2010-09-22
author: Hor H
date: 2010-08-15
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20711174
trait: Narcolepsy
initial_samplesize: 562 European ancestry cases, 702 European ancestry controls
replication_samplesize: 370 cases, 495 controls
region: 14q11.2
chrom: 14
reported_genes: TRA@
mapped_gene: TRA
snp_gene_ids: 6955
strongest_risk_snp: rs1154155
strongest_risk_allele: G
snps: rs1154155
snp_id_current: 1154155
pvalue_mlog: 6.30102999566398
ci_95: [1.30-1.95]
platform: Affymetrix [392,949]
cnv: N
study:
Genome-wide association study identifies new HLA class II haplotypes strongly protective against narcolepsy.


dbdate: 2010-09-22
author: Nakashima M
date: 2010-08-15
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20711176
trait: Keloid
initial_samplesize: 178 Japanese ancestry cases, 906 Japanese ancestry controls
replication_samplesize: 621 Japanese ancestry cases, 2,271 Japanese ancestry controls
region: 1q41
chrom: 1
reported_genes: Intergenic
mapped_gene: DUSP10 - QRSL1P2
upstream_gene_id: 11221
downstream_gene_id: 100422330
strongest_risk_snp: rs873549
strongest_risk_allele: C
snps: rs873549
snp_id_current: 873549
context: Intergenic
pvalue_mlog: 22.22184874961636
ci_95: [1.58-1.99]
platform: Illumina [452,038]
cnv: N
study:
A genome-wide association study identifies four susceptibility loci for keloid in the Japanese population.


dbdate: 2010-09-21
author: O'Seaghdha CM
date: 2010-08-12
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20705733
trait: Calcium levels
initial_samplesize: 20,611 European ancestry individuals
region: 2p23.3
chrom: 2
reported_genes: GCKR,IFT172,FNDC4,C2orf16
mapped_gene: GCKR
snp_gene_ids: 2646
strongest_risk_snp: rs780093
strongest_risk_allele: T
snps: rs780093
snp_id_current: 780093
context: intron
pvalue_mlog: 5.154901959985742
ci_95: [NR] unit increase
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Common variants in the calcium-sensing receptor gene are associated with total serum calcium levels.


dbdate: 2010-09-24
author: Chalasani N
date: 2010-08-10
journal: Gastroenterology
link: http://www.ncbi.nlm.nih.gov/pubmed/20708005
trait: Non-alcoholic fatty liver disease histology (AST)
initial_samplesize: 236 European Ancestry cases
region: 1q43
chrom: 1
reported_genes: ZP4
mapped_gene: ZP4 - MTND2P27
upstream_gene_id: 57829
downstream_gene_id: 100873232
strongest_risk_snp: rs2499604
strongest_risk_allele: A
snps: rs2499604
snp_id_current: 2499604
context: Intergenic
pvalue_mlog: 5.698970004336018
ci_95: [NR] unit decrease
platform: Illumina [324,623]
cnv: N
study:
Genome-wide association study identifies variants associated with histologic features of nonalcoholic Fatty liver disease.


dbdate: 2010-09-15
author: Davila S
date: 2010-08-08
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20694013
trait: Meningococcal disease
initial_samplesize: 475 European ancestry cases, 4,703 European ancestry controls
replication_samplesize: 929 European ancestry cases, 1,351 European ancestry controls
region: 1q31.3
chrom: 1
reported_genes: CFH,CFHR3
mapped_gene: CFHR3
snp_gene_ids: 10878
strongest_risk_snp: rs426736
snps: rs426736
snp_id_current: 426736
context: intron
pvalue_mlog: 12.30102999566398
ci_95: [1.41-1.82]
platform: Illumina [518,920]
cnv: N
study:
Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease.


dbdate: 2010-09-16
author: Thye T
date: 2010-08-08
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20694014
trait: Tuberculosis
initial_samplesize: 2,237 Sub-Saharan African ancestry cases, 3,122 Sub-Saharan African ancestry controls
replication_samplesize: 1,462 Sub-Saharan African ancestry cases, 4,604 Sub-Saharan African ancestry controls
region: 2q33.3
chrom: 2
reported_genes: Intergenic
mapped_gene: PARD3B
snp_gene_ids: 117583
strongest_risk_snp: rs2335704
strongest_risk_allele: C
snps: rs2335704
snp_id_current: 2335704
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [1.10-1.30]
platform: Affymetrix [>333,754] (imputed)
cnv: N
study:
Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2.


dbdate: 2010-09-15
author: Meyer TE
date: 2010-08-05
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20700443
trait: Magnesium levels
initial_samplesize: 15,366 European ancestry individuals
replication_samplesize: 8,463 European ancestry individuals
region: 1q22
chrom: 1
reported_genes: MUC1
mapped_gene: MUC1
snp_gene_ids: 4582
strongest_risk_snp: rs4072037
strongest_risk_allele: C
snps: rs4072037
snp_id_current: 4072037
context: cds-synon
pvalue_mlog: 35.69897000433601
ci_95: [0.008-0.012] mmol/L decrease
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Genome-wide association studies of serum magnesium, potassium, and sodium concentrations identify six Loci influencing serum magnesium levels.


dbdate: 2010-09-14
author: Verweij KJ
date: 2010-08-04
journal: Biol Psychol
link: http://www.ncbi.nlm.nih.gov/pubmed/20691247
trait: Personality dimensions
initial_samplesize: 5,117 European ancestry individuals from 2567 families
region: 16q12.1
chrom: 16
reported_genes: Intergenic
mapped_gene: UNGP1 - HNRNPA1P48
upstream_gene_id: 57004
downstream_gene_id: 642659
strongest_risk_snp: rs4131099
strongest_risk_allele: A
snps: rs4131099
snp_id_current: 4131099
context: Intergenic
pvalue_mlog: 5.397940008672037
ci_95: [NR] unit increase
platform: Affymetrix & Illumina [1,252,387] (imputed)
cnv: N
study:
A genome-wide association study of Cloninger's temperament scales: implications for the evolutionary genetics of personality.


dbdate: 2013-08-16
author: Dubinsky MC
date: 2010-08-01
journal: Inflamm Bowel Dis
link: http://www.ncbi.nlm.nih.gov/pubmed/20014019
trait: Response to anti-TNF alpha therapy in inflammatory bowel disease
initial_samplesize: 94 Other ancestry pediatric cases
region: 13q31.1
chrom: 13
reported_genes: RBM26
mapped_gene: RBM26
snp_gene_ids: 64062
strongest_risk_snp: rs1155848
snps: rs1155848
snp_id_current: 1155848
context: UTR-3
pvalue_mlog: 6.30102999566398
ci_95: [NR]
platform: Illumina [301,742]
cnv: N
study:
Genome wide association (GWA) predictors of anti-TNFalpha therapeutic responsiveness in pediatric inflammatory bowel disease.


dbdate: 2010-09-11
author: Takata R
date: 2010-08-01
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20676098
trait: Prostate cancer
initial_samplesize: 1,583 Japanese ancestry cases, 3,386 Japanese ancestry controls
replication_samplesize: 3,001 Japanese ancestry cases, 5,415 Japanese ancestry controls
region: 2p24.1
chrom: 2
reported_genes: C2orf43
mapped_gene: C2orf43
snp_gene_ids: 60526
strongest_risk_snp: rs13385191
strongest_risk_allele: G
snps: rs13385191
snp_id_current: 13385191
context: intron
pvalue_mlog: 7.096910013008055
ci_95: [1.10-1.21]
platform: Illumina [510,687]
cnv: N
study:
Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.


dbdate: 2010-09-11
author: Zhang H
date: 2010-08-01
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20676096
trait: Hepatocellular carcinoma
initial_samplesize: 348 Chinese ancestry cases, 359 Chinese ancestry controls
replication_samplesize: 2,121 Chinese ancestry cases, 1,748 Chinese ancestry controls
region: 1p36.22
chrom: 1
reported_genes: KIF1B,UBE4B,PGD
mapped_gene: KIF1B
snp_gene_ids: 23095
strongest_risk_snp: rs17401966
strongest_risk_allele: A
snps: rs17401966
snp_id_current: 17401966
context: intron
pvalue_mlog: 17.69897000433602
ci_95: [1.49-1.82]
platform: Affymetrix [294,566]
cnv: N
study:
Genome-wide association study identifies 1p36.22 as a new susceptibility locus for hepatocellular carcinoma in chronic hepatitis B virus carriers.


dbdate: 2010-09-14
author: Reed DR
date: 2010-07-31
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20675712
trait: Bitter taste response
initial_samplesize: 1,457 European ancestry individuals
replication_samplesize: 73 European ancestry individuals
region: 7q34
chrom: 7
reported_genes: TAS2R38
mapped_gene: TAS2R38;MGAM
snp_gene_ids: 5726;8972
strongest_risk_snp: rs713598
snps: rs713598
snp_id_current: 713598
context: missense;intron
pvalue_mlog: 103.698970004336
platform: Illumina [~2.3 million] (imputed)
cnv: N
study:
The perception of quinine taste intensity is associated with common genetic variants in a bitter receptor cluster on chromosome 12.


dbdate: 2010-09-11
author: Gudbjartsson DF
date: 2010-07-29
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20686651
trait: Chronic kidney disease and serum creatinine levels
initial_samplesize: 1,689 European ancestry cases, 37,076 European ancestry controls
replication_samplesize: 1,972 European ancestry cases, 6,125 European ancestry controls
region: 16p12.3
chrom: 16
reported_genes: UMOD
mapped_gene: UMOD
snp_gene_ids: 7369
strongest_risk_snp: rs4293393
strongest_risk_allele: T
snps: rs4293393
snp_id_current: 4293393
context: nearGene-5
pvalue_mlog: 9.397940008672037
ci_95: [1.17-1.35]
platform: Illumina [~2.5 million] (imputed)
cnv: N
study:
Association of variants at UMOD with chronic kidney disease and kidney stones-role of age and comorbid diseases.


dbdate: 2010-09-10
author: Kim HN
date: 2010-07-29
journal: J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20668459
trait: Height
initial_samplesize: 518 individuals from 165 Vietnamese-Korean families
region: 16q23.2
chrom: 16
reported_genes: MAF
mapped_gene: RNA5SP431 - MAF
upstream_gene_id: 100873681
downstream_gene_id: 4094
strongest_risk_snp: rs7498403
strongest_risk_allele: C
snps: rs7498403
snp_id_current: 7498403
context: Intergenic
pvalue_mlog: 5.301029995663981
platform: Illumina [269,888]
cnv: N
study:
Genetic variants that affect length/height in infancy/early childhood in Vietnamese-Korean families.


dbdate: 2010-09-10
author: Rietschel M
date: 2010-07-29
journal: Biol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/20673876
trait: Major depressive disorder
initial_samplesize: 597 European ancestry cases, 1,295 European ancestry controls
replication_samplesize: 409 European ancestry cases, 541 European ancestry controls
region: 5q14.1
chrom: 5
reported_genes: HOMER1
mapped_gene: RPL7AP32 - PAPD4
upstream_gene_id: 133748
downstream_gene_id: 167153
strongest_risk_snp: rs7713917
strongest_risk_allele: G
snps: rs7713917
snp_id_current: 7713917
context: Intergenic
pvalue_mlog: 5.999999999999999
ci_95: [1.19-1.49]
platform: Illumina [491,238]
cnv: N
study:
Genome-wide association-, replication-, and neuroimaging study implicates HOMER1 in the etiology of major depression.


dbdate: 2010-09-10
author: Genovese G
date: 2010-07-28
journal: Kidney Int
link: http://www.ncbi.nlm.nih.gov/pubmed/20668430
trait: Glomerulosclerosis
replication_samplesize: 299 European ancestry cases
region: 22q12.3
chrom: 22
reported_genes: APOL1, MYH9
mapped_gene: APOL1
snp_gene_ids: 8542
strongest_risk_snp: rs2239785
strongest_risk_allele: G
snps: rs2239785
snp_id_current: 2239785
context: missense
pvalue_mlog: 12.30102999566398
platform: Illumina [up to ~542,539]
cnv: N
study:
A risk allele for focal segmental glomerulosclerosis in African Americans is located within a region containing APOL1 and MYH9.

initial_samplesize:
56 African American cases, 61 European ancestry cases, 1,759 African American controls, 1,531 European ancestry controls


dbdate: 2010-09-07
author: Clancy RM
date: 2010-07-26
journal: Arthritis Rheum
link: http://www.ncbi.nlm.nih.gov/pubmed/20662065
trait: Neonatal lupus
initial_samplesize: 116 European ancestry cases, 3,351 European ancestry controls
region: 21q22.2
chrom: 21
reported_genes: NCRNA00114, ERG
mapped_gene: SNRPGP13 - LINC00114
upstream_gene_id: 100874428
downstream_gene_id: 400866
strongest_risk_snp: rs743446
snps: rs743446
snp_id_current: 743446
context: Intergenic
pvalue_mlog: 5.301029995663981
ci_95: [1.64-3.49]
platform: Illumina [346,110]
cnv: N
study:
Identification of candidate loci at 6p21 and 21q22 in a genome-wide association study of cardiac manifestations of neonatal lupus.


dbdate: 2010-09-10
author: Johansen CT
date: 2010-07-25
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20657596
trait: Hypertriglyceridemia
initial_samplesize: 463 European ancestry cases, 1,197 European ancestry controls
region: 11q23.3
chrom: 11
reported_genes: APOA5
mapped_gene: ZPR1
snp_gene_ids: 8882
strongest_risk_snp: rs964184
strongest_risk_allele: G
snps: rs964184
snp_id_current: 964184
context: intron
pvalue_mlog: 23.30102999566398
ci_95: [2.61-4.14]
platform: Affymetrix [~2.1 million] (imputed)
cnv: N
study:
Excess of rare variants in genes identified by genome-wide association study of hypertriglyceridemia.


dbdate: 2010-09-07
author: Kapur K
date: 2010-07-22
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20661308
trait: Calcium levels
initial_samplesize: 8,918 European ancestry individuals, 3,947 Indian Asians ancestry individuals
replication_samplesize: 4,126 European ancestry individuals
region: 3q21.1
chrom: 3
reported_genes: CASR
mapped_gene: CASR
snp_gene_ids: 846
strongest_risk_snp: rs1801725
strongest_risk_allele: T
snps: rs1801725
snp_id_current: 1801725
context: missense
pvalue_mlog: 36.22184874961636
ci_95: [0.0031-0.0042] increase in log(CASR, mmol/L)
platform: Affymetrix, Illumina and Perlegen [2,557,252] (imputed)
cnv: N
study:
Genome-wide meta-analysis for serum calcium identifies significantly associated SNPs near the calcium-sensing receptor (CASR) gene.


dbdate: 2010-09-01
author: Ochi H
date: 2010-07-13
journal: Gastroenterology
link: http://www.ncbi.nlm.nih.gov/pubmed/20637204
trait: Ribavirin-induced anemia
initial_samplesize: 453 Japanese ancestry individuals
replication_samplesize: 470 Japanese ancestry individuals
region: 20p13
chrom: 20
reported_genes: DDRGK1,ITPA
mapped_gene: ITPA
snp_gene_ids: 3704
strongest_risk_snp: rs1127354
strongest_risk_allele: A
snps: rs1127354
snp_id_current: 1127354
context: missense
pvalue_mlog: 43.39794000867204
platform: Illumina [510,537]
cnv: N
study:
ITPA polymorphism affects ribavirin-induced anemia and outcomes of therapy--a genome-wide study of Japanese HCV virus patients.


dbdate: 2010-09-01
author: Gretarsdottir S
date: 2010-07-11
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20622881
trait: Abdominal aortic aneurysm
initial_samplesize: 1,292 European ancestry cases, 30,503 European ancestry controls
replication_samplesize: 3,267 European ancestry cases, 7,451 European ancestry controls
region: 9q33.2
chrom: 9
reported_genes: DAB2IP
mapped_gene: DAB2IP
snp_gene_ids: 153090
strongest_risk_snp: rs7025486
strongest_risk_allele: A
snps: rs7025486
snp_id_current: 7025486
context: intron
pvalue_mlog: 9.301029995663981
ci_95: [1.14-1.28]
platform: Illumina [293,677]
cnv: N
study:
Genome-wide association study identifies a sequence variant within the DAB2IP gene conferring susceptibility to abdominal aortic aneurysm.


dbdate: 2010-08-30
author: Mizuki N
date: 2010-07-11
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20622879
trait: Behcet's disease
initial_samplesize: 611 Japanese ancestry cases, 737 Japanese ancestry controls
region: 1p31.3
chrom: 1
reported_genes: IL23R,IL12RB2
mapped_gene: IL23R - IL12RB2
upstream_gene_id: 149233
downstream_gene_id: 3595
strongest_risk_snp: rs1495965
strongest_risk_allele: G
snps: rs1495965
snp_id_current: 1495965
context: Intergenic
pvalue_mlog: 10.69897000433602
ci_95: [1.24-1.47]
platform: Affymetrix [320,438]
cnv: N
study:
Genome-wide association studies identify IL23R-IL12RB2 and IL10 as Beh&#x000e7;et's disease susceptibility loci.

replication_samplesize:
119 Korean ancestry cases, 140 Korean ancestry controls, 1,215 Turkish cases, 1,279 Turkish controls


dbdate: 2010-08-18
author: Remmers EF
date: 2010-07-11
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20622878
trait: Behcet's disease
initial_samplesize: 1,215 Turkish ancestry cases, 1,278 Turkish ancestry controls
region: 1q32.1
chrom: 1
reported_genes: IL10
mapped_gene: IL10
snp_gene_ids: 3586
strongest_risk_snp: rs1518111
snps: rs1518111
snp_id_current: 1518111
context: intron
pvalue_mlog: 17.39794000867204
ci_95: [1.34-1.58]
platform: Illumina [311,459]
cnv: N
study:
Genome-wide association study identifies variants in the MHC class I, IL10, and IL23R-IL12RB2 regions associated with Beh&#x000e7;et's disease.

replication_samplesize:
Up to 111 Turkish ancestry cases, 225 Turkish ancestry controls, 189 Middle Eastern Arab ancestry cases, 163 Middle Eastern Arab ancestry controls, 227 European ancestry cases, 203 European ancestry controls, 688 East Asian ancestry cases, 791 East Asian ancestry controls


dbdate: 2010-08-11
author: Uno S
date: 2010-07-04
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20601957
trait: Endometriosis
initial_samplesize: 1,423 Japanese ancestry cases, 1,318 Japanese ancestry controls
replication_samplesize: 484 Japanese ancestry cases, 3,974 Japanese ancestry controls
region: 9p21.3
chrom: 9
reported_genes: CDKN2BAS
mapped_gene: CDKN2B-AS1
snp_gene_ids: 100048912
strongest_risk_snp: rs10965235
strongest_risk_allele: C
snps: rs10965235
snp_id_current: 10965235
context: intron
pvalue_mlog: 11.22184874961635
ci_95: [1.30-1.59]
platform: Illumina [460,945]
cnv: N
study:
A genome-wide association study identifies genetic variants in the CDKN2BAS locus associated with endometriosis in Japanese.


dbdate: 2010-08-17
author: Koriyama H
date: 2010-07-02
journal: J Atheroscler Thromb
link: http://www.ncbi.nlm.nih.gov/pubmed/20610895
trait: Peripheral artery disease
initial_samplesize: 195 Japanese ancestry cases, 1,358 Japanese ancestry controls
replication_samplesize: 699 Japanese ancestry cases, 1,540 Japanese ancestry controls
region: 3p23
chrom: 3
reported_genes: OSBPL10
mapped_gene: OSBPL10
snp_gene_ids: 114884
strongest_risk_snp: rs1902341
strongest_risk_allele: G
snps: rs1902341
snp_id_current: 1902341
context: intron
pvalue_mlog: 6.30102999566398
ci_95: [1.18-1.46]
platform: Perlegen [222,285]
cnv: N
study:
Identification of evidence suggestive of an association with peripheral arterial disease at the OSBPL10 locus by genome-wide investigation in the Japanese population.


dbdate: 2013-11-09
author: Chen SH
date: 2010-06-30
journal: Clin Pharmacol Ther
link: http://www.ncbi.nlm.nih.gov/pubmed/20592726
study: Genetic variations in GRIA1 on chromosome 5q33 related to asparaginase hypersensitivity.
trait: Asparaginase hypersensitivity in acute lymphoblastic leukemia
region: 5q33.2
chrom: 5
reported_genes: GRIA1
mapped_gene: GRIA1
snp_gene_ids: 2890
strongest_risk_snp: rs4958351
strongest_risk_allele: A
snps: rs4958351
snp_id_current: 4958351
context: intron
pvalue_mlog: 6.397940008672037
ci_95: [1.41-2.17]
platform: Affymetrix [364,033]
cnv: N
initial_samplesize:
211 European ancestry child cases, 40 Black child cases, 46 Hispanic child cases, 4 Asian child cases, 21 Other ancestry child cases

replication_samplesize:
99 European ancestry child cases, 33 Black child cases, 24 Hispanic child cases, 2 Asian child cases, 5 Other ancestry child cases


dbdate: 2010-07-13
author: Dick DM
date: 2010-06-27
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/20585324
study: Genome-wide association study of conduct disorder symptomatology.
trait: Conduct disorder
region: 4p15.32
chrom: 4
reported_genes: C1QTNF7
mapped_gene: C1QTNF7
snp_gene_ids: 114905
strongest_risk_snp: rs1861046
strongest_risk_allele: A
snps: rs1861046
snp_id_current: 1861046
context: intron
pvalue_mlog: 7.221848749616355
ci_95: [1.38-1.98]
platform: Illumina [948,658]
cnv: N
initial_samplesize:
872 European, African American and other ancestry substance dependence cases; 3,091 European, African American and other ancestry controls


dbdate: 2010-07-12
author: Long J
date: 2010-06-24
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20585626
trait: Breast cancer
initial_samplesize: 2,073 Chinese ancestry cases, 2,084 Chinese ancestry controls
region: 16q12.1
chrom: 16
reported_genes: TOX3
mapped_gene: CASC16
snp_gene_ids: 643714
strongest_risk_snp: rs4784227
strongest_risk_allele: T
snps: rs4784227
snp_id_current: 4784227
context: intron
pvalue_mlog: 28
ci_95: [1.20-1.29]
platform: Affymetrix [684,457]
cnv: N
study:
Identification of a functional genetic variant at 16q12.1 for breast cancer risk: results from the Asia Breast Cancer Consortium.

replication_samplesize:
15,159 East Asian ancestry cases, 12,993 East Asian ancestry controls, 2,797 European ancestry cases, 2,662 European ancestry controls


dbdate: 2010-07-04
author: Hsu YH
date: 2010-06-10
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20548944
trait: Osteoporosis-related phenotypes
initial_samplesize: 2,038 European ancestry women, 1,531 European ancestry men
replication_samplesize: 5,595 European ancestry women, 2,126 European ancestry men
region: 1p13.2
chrom: 1
reported_genes: RAP1A
mapped_gene: RAP1A
snp_gene_ids: 5906
strongest_risk_snp: rs494453
strongest_risk_allele: C
snps: rs494453
snp_id_current: 494453
context: intron
pvalue_mlog: 7.397940008672037
platform: Affymetrix [433,510]
cnv: N
study:
An integration of genome-wide association study and gene expression profiling to prioritize the discovery of novel susceptibility Loci for osteoporosis-related traits.


dbdate: 2010-07-01
author: Bostrom MA
date: 2010-06-08
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20532800
trait: End-stage renal disease (non-diabetic)
initial_samplesize: 464 African American cases, 478 African American controls
replication_samplesize: 336 African American cases, 363 African American controls
region: 22q12.3
chrom: 22
reported_genes: MYH9
mapped_gene: APOL4 - APOL2
upstream_gene_id: 80832
downstream_gene_id: 23780
strongest_risk_snp: rs4821469
snps: rs4821469
snp_id_current: 4821469
context: Intergenic
pvalue_mlog: 18.69897000433602
ci_95: [2.27-3.57]
platform: Illumina [~550,000] (pooled)
cnv: N
study:
Candidate genes for non-diabetic ESRD in African Americans: a genome-wide association study using pooled DNA.


dbdate: 2010-06-22
author: Johnson AD
date: 2010-06-06
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20526338
trait: Platelet aggregation
initial_samplesize: Up to 3,991 European ancestry individuals
replication_samplesize: Up to 840 African American individuals
region: 1q23.1
chrom: 1
reported_genes: PEAR1
mapped_gene: PEAR1
snp_gene_ids: 375033
strongest_risk_snp: rs12566888
strongest_risk_allele: A
snps: rs12566888
snp_id_current: 12566888
context: intron
pvalue_mlog: 15.39794000867204
platform: Affymetrix & Illumina [~2.33 million] (imputed)
cnv: N
study:
Genome-wide meta-analyses identifies seven loci associated with platelet aggregation in response to agonists.


dbdate: 2010-06-14
author: Bei JX
date: 2010-05-30
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20512145
trait: Nasopharyngeal carcinoma
initial_samplesize: 1,583 Chinese ancestry cases, 1,894 Chinese ancestry controls
replication_samplesize: 3,507 Chinese ancestry cases, 3,063 Chinese ancestry controls, 284 Chinese ancestry trios
region: 6p22.1
chrom: 6
reported_genes: HLA-A
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs2860580
snps: rs2860580
snp_id_current: 2860580
pvalue_mlog: 66.30102999566397
ci_95: [1.61-1.82]
platform: Illumina [464,328]
cnv: N
study:
A genome-wide association study of nasopharyngeal carcinoma identifies three new susceptibility loci.


dbdate: 2010-06-14
author: Lu Y
date: 2010-05-13
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20485516
trait: Central corneal thickness
region: 13q14.11
chrom: 13
reported_genes: FOXO1
mapped_gene: LOC100289058
snp_gene_ids: 100289058
strongest_risk_snp: rs2721051
strongest_risk_allele: G
snps: rs2721051
snp_id_current: 2721051
pvalue_mlog: 9.301029995663981
ci_95: [0.16-0.32] unit decrease
platform: Illumina [~2.4 million] (pooled)
cnv: N
study:
Common genetic variants near the Brittle Cornea Syndrome locus ZNF469 influence the blinding disease risk factor central corneal thickness.

initial_samplesize:
3,473 European ancestry twins in 1,905 families, 301 European ancestry thin CCT cases, 301 European ancestry thick CCT controls


dbdate: 2010-06-02
author: Smith NL
date: 2010-05-05
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20445134
trait: Heart failure
initial_samplesize: 20,926 European ancestry individuals, 2,895 African ancestry individuals
region: 15q22.31
chrom: 15
reported_genes: USP3
mapped_gene: CA12 - USP3
upstream_gene_id: 771
downstream_gene_id: 9960
strongest_risk_snp: rs10519210
snps: rs10519210
snp_id_current: 10519210
context: Intergenic
pvalue_mlog: 8
ci_95: [1.05-2.24]
platform: Affymetrix & Illumina [2,478,304] (imputed)
cnv: N
study:
Association of genome-wide variation with the risk of incident heart failure in adults of European and African ancestry: a prospective meta-analysis from the cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.


dbdate: 2010-05-31
author: Albagha OM
date: 2010-05-02
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20436471
trait: Paget's disease
initial_samplesize: 692 European ancestry cases, 1,001 European ancestry controls
replication_samplesize: 256 European ancestry cases, 488 European ancestry controls
region: 10p13
chrom: 10
reported_genes: OPTN
mapped_gene: OPTN
snp_gene_ids: 10133
strongest_risk_snp: rs1561570
snps: rs1561570
snp_id_current: 1561570
context: intron
pvalue_mlog: 12.22184874961636
ci_95: [1.37-1.72]
platform: Illumina [294,663]
cnv: N
study:
Genome-wide association study identifies variants at CSF1, OPTN and TNFRSF11A as genetic risk factors for Paget's disease of bone.


dbdate: 2010-05-26
author: Beaty TH
date: 2010-05-02
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20436469
trait: Cleft lip
initial_samplesize: 825 European ancestry trios, 1,038 Asian ancestry trios
region: 8q24.21
chrom: 8
reported_genes: Intergenic
mapped_gene: LINC01263 - LINC00977
upstream_gene_id: 101927774
downstream_gene_id: 728724
strongest_risk_snp: rs987525
strongest_risk_allele: A
snps: rs987525
snp_id_current: 987525
context: Intergenic
pvalue_mlog: 15.39794000867204
ci_95: [1.55-2.05]
platform: Illumina [589,945]
cnv: N
study:
A genome-wide association study of cleft lip with and without cleft palate identifies risk variants near MAFB and ABCA4.

replication_samplesize:
2,194 Asian ancestry family members, 322 South Asian ancestry family members, 3,830 European ancestry family members, 1,769 South and Central American ancestry family members


dbdate: 2014-06-26
author: Scherag A
date: 2010-04-22
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20421936
trait: Obesity (early onset extreme)
initial_samplesize: 1,138 European ancestry cases, 1,120 European ancestry normal or lean controls
region: 16q12.2
chrom: 16
reported_genes: FTO
mapped_gene: FTO
snp_gene_ids: 79068
strongest_risk_snp: rs1558902
strongest_risk_allele: A
snps: rs1558902
snp_id_current: 1558902
context: intron
pvalue_mlog: 18.30102999566398
ci_95: [1.26-1.50]
platform: Affymetrix and Illumina [1,596,878] (imputed)
cnv: N
study:
Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups.

replication_samplesize:
1,181 European ancestry cases, 1,960 European ancestry normal or lean controls, 981 European ancestry cases  and 1,430 European ancestry controls from 715 families


dbdate: 2010-05-18
author: Jin Y
date: 2010-04-21
journal: N Engl J Med
link: http://www.ncbi.nlm.nih.gov/pubmed/20410501
study: Variant of TYR and autoimmunity susceptibility loci in generalized vitiligo.
trait: Vitiligo
initial_samplesize: 1,392 European ancestry cases, 2,629 European ancestry controls
region: 1p36.23
chrom: 1
reported_genes: RERE
mapped_gene: RERE
snp_gene_ids: 473
strongest_risk_snp: rs4908760
strongest_risk_allele: G
snps: rs4908760
snp_id_current: 4908760
context: intron
pvalue_mlog: 14.15490195998574
ci_95: [1.26-1.48]
platform: Illumina [520,460]
cnv: N
replication_samplesize:
647 European ancestry cases, 1,056 European ancestry controls, 183 European ancestry trios, 1,383 European ancestry individuals from 332 families


dbdate: 2010-05-23
author: Morrison AC
date: 2010-04-17
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20400778
trait: Mortality in heart failure
region: 3p22.3
chrom: 3
reported_genes: CMTM7
mapped_gene: CMTM7
snp_gene_ids: 112616
strongest_risk_snp: rs12638540
strongest_risk_allele: G
snps: rs12638540
snp_id_current: 12638540
context: intron
pvalue_mlog: 6.522878745280337
ci_95: [1.01-2.31]
platform: Affymetrix [up to 2,366,858] (imputed)
cnv: N
study:
Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.

initial_samplesize:
1,645 European ancestry cases, 881 European ancestry controls, 281 African ancestry cases, 185 African ancestry controls


dbdate: 2014-07-01
author: Chen W
date: 2010-04-12
journal: Proc Natl Acad Sci U S A
link: http://www.ncbi.nlm.nih.gov/pubmed/20385819
trait: Age-related macular degeneration
initial_samplesize: 2,157 European ancestry cases, 1,150 European ancestry controls
region: 22q12.3
reported_genes: TIMP3, SYN3
strongest_risk_snp: rs9621532
strongest_risk_allele: A
snps: rs9621532
ci_95: [1.27-1.57]
platform: Illumina [~2.5 million] (imputed)
cnv: N
study:
Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.

replication_samplesize:
7,892 European ancestry cases, 678 Japanese cases, 5,998 European ancestry controls, 336 Japanese controls


dbdate: 2010-05-06
author: Neale BM
date: 2010-04-12
journal: Proc Natl Acad Sci U S A
link: http://www.ncbi.nlm.nih.gov/pubmed/20385826
trait: Age-related macular degeneration
initial_samplesize: 979 cases, 1,709 controls
replication_samplesize: 868 European ancestry cases, 410 European ancestry controls, 4,921 cases, 3,824 controls
region: 15q21.3
chrom: 15
reported_genes: LIPC
mapped_gene: LOC102724766
snp_gene_ids: 102724766
strongest_risk_snp: rs10468017
snps: rs10468017
snp_id_current: 10468017
context: intron
pvalue_mlog: 8
ci_95: [1.14-1.30]
platform: Affymetrix [632,932]
cnv: N
study:
Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).


dbdate: 2010-04-27
author: Freathy RM
date: 2010-04-06
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20372150
study: Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight.
trait: Birth weight
initial_samplesize: 10,623 European ancestry individuals
region: 3q25.31
chrom: 3
reported_genes: CCNL1, LEKR1
mapped_gene: KLF3P2 - LINC00880
upstream_gene_id: 100124394
downstream_gene_id: 339894
strongest_risk_snp: rs900400
strongest_risk_allele: C
snps: rs900400
snp_id_current: 900400
context: Intergenic
pvalue_mlog: 34.69897000433602
ci_95: [0.073-0.10] s.d. decrease
platform: Affymetrix & Illumina [~2.4 million] (imputed)
cnv: N
replication_samplesize:
27,591 European ancestry individuals, 1,415 Filipino ancestry individuals, 746 North African ancestry individuals, 333 Turkish ancestry individuals


dbdate: 2010-05-03
author: Meguro A
date: 2010-04-02
journal: Ophthalmology
link: http://www.ncbi.nlm.nih.gov/pubmed/20363506
trait: Glaucoma
initial_samplesize: 305 Japanese ancestry cases, 355 Japanese ancestry controls
region: 2p21
chrom: 2
reported_genes: SRBD1
mapped_gene: SRBD1
snp_gene_ids: 55133
strongest_risk_snp: rs3213787
strongest_risk_allele: A
snps: rs3213787
snp_id_current: 3213787
context: intron
pvalue_mlog: 8.522878745280337
ci_95: [1.96-3.99]
platform: Affymetrix [325,947]
cnv: N
study:
Genome-wide association study of normal tension glaucoma: common variants in SRBD1 and ELOVL5 contribute to disease susceptibility.


dbdate: 2010-04-15
author: Liu Y
date: 2010-03-30
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/20351715
study: Meta-analysis of genome-wide association data of bipolar disorder and major depressive disorder.
trait: Bipolar disorder and major depressive disorder (combined)
region: 12p13.33
chrom: 12
reported_genes: CACNA1C
mapped_gene: CACNA1C
snp_gene_ids: 775
strongest_risk_snp: rs1006737
strongest_risk_allele: A
snps: rs1006737
snp_id_current: 1006737
context: intron
pvalue_mlog: 7.522878745280337
ci_95: [NR] (bipolar)
platform: Affymetrix & Perlegen [1,472,580] (imputed)
cnv: N
initial_samplesize:
4,387 European ancestry bipolar cases, 1,695 European ancestry major depressive disorder cases, 7,970 European ancestry controls


dbdate: 2013-11-03
author: Takahashi M
date: 2010-03-29
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20350937
trait: Thyroid cancer (Papillary, radiation-related)
initial_samplesize: 401 European ancestry cases, 620 European ancestry controls,
replication_samplesize: 259 Other ancestry cases, 648 Other ancestry controls
region: 9q22.33
chrom: 9
reported_genes: FOXE1, TMOD1, C9orf97, NCBP1, XPA, KRT18P13, C9orf156, HEMGN
mapped_gene: KRT18P13 - FOXE1
upstream_gene_id: 392371
downstream_gene_id: 2304
strongest_risk_snp: rs965513
strongest_risk_allele: A
snps: rs965513
snp_id_current: 965513
context: Intergenic
pvalue_mlog: 11.30102999566398
ci_95: [1.43-1.91]
platform: Illumina [506,840]
cnv: N
study:
The FOXE1 locus is a major genetic determinant for radiation-related thyroid carcinoma in Chernobyl.


dbdate: 2013-10-18
author: Kim S
date: 2010-03-23
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/20308991
trait: Brain cytoarchitecture
region: 5q22.2
chrom: 5
reported_genes: MCC
mapped_gene: MCC
snp_gene_ids: 4163
strongest_risk_snp: rs6594713
snps: rs6594713
snp_id_current: 6594713
context: intron
pvalue_mlog: 5.698970004336018
platform: Affymetrix [309,531]
cnv: N
study:
Integrative genome-wide association analysis of cytoarchitectural abnormalities in the prefrontal cortex of psychiatric disorders.

initial_samplesize:
14 European ancestry bipolar cases, 15 European ancestry depression cases, 13 European ancestry schizophrenia cases, 14 European ancestry controls


dbdate: 2010-03-29
author: Li Y
date: 2010-03-19
journal: Lancet Oncol
link: http://www.ncbi.nlm.nih.gov/pubmed/20304703
study: Genetic variants and risk of lung cancer in never smokers: a genome-wide association study.
trait: Lung cancer
region: 13q31.3
chrom: 13
reported_genes: GPC5
mapped_gene: GPC5
snp_gene_ids: 2262
strongest_risk_snp: rs2352028
strongest_risk_allele: A
snps: rs2352028
snp_id_current: 2352028
context: intron
pvalue_mlog: 5.221848749616356
ci_95: [1.26-1.70]
platform: Illumina [331,918]
cnv: N
initial_samplesize:
364 European ancestry cases, 364 European ancestry controls, 13 Other ancestry cases, 13 Other ancestry controls

replication_samplesize:
446 European ancestry cases, 853 European ancestry controls, 65 Other ancestry cases, 154 Other ancestry controls


dbdate: 2010-04-12
author: Houlihan LM
date: 2010-03-18
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20303064
trait: Activated partial thromboplastin time
initial_samplesize: 1,431 European ancestry individuals
region: 5q35.3
chrom: 5
reported_genes: F12
mapped_gene: F12 - GRK6
upstream_gene_id: 2161
downstream_gene_id: 2870
strongest_risk_snp: rs2731672
strongest_risk_allele: A
snps: rs2731672
snp_id_current: 2731672
context: Intergenic
pvalue_mlog: 29.69897000433602
ci_95: [0.37-0.53] unit decrease
platform: Illumina [542,050]
cnv: N
study:
Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time.


dbdate: 2010-04-02
author: Medland SE
date: 2010-03-18
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20303062
trait: Digit length ratio
initial_samplesize: 2,889 European ancestry children and adolescents
replication_samplesize: 3,659 European ancestry children
region: 6q16.3
chrom: 6
reported_genes: LIN28B
mapped_gene: LIN28B
snp_gene_ids: 389421
strongest_risk_snp: rs314277
strongest_risk_allele: A
snps: rs314277
snp_id_current: 314277
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [0.41-0.85] increase in mean 2D:4D
platform: Illumina [310,613]
cnv: N
study:
A variant in LIN28B is associated with 2D:4D finger-length ratio, a putative retrospective biomarker of prenatal testosterone exposure.


dbdate: 2010-04-02
author: Nakajima M
date: 2010-03-18
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/20305777
trait: Knee osteoarthritis
initial_samplesize: 899 Japanese ancestry cases, 3,396 Japanese ancestry controls
region: 6p21.32
chrom: 6
reported_genes: BTNL2, HLA-DQA2, HLA-DQB1
mapped_gene: BTNL2;LOC101929163
snp_gene_ids: 56244;101929163;102725030
strongest_risk_snp: rs10947262
strongest_risk_allele: T
snps: rs10947262
snp_id_current: 10947262
context: intron;ncRNA;ncRNA
pvalue_mlog: 8.301029995663981
ci_95: [1.20-1.44]
platform: Illumina [459,393]
cnv: N
study:
New sequence variants in HLA class II/III region associated with susceptibility to knee osteoarthritis identified by genome-wide association study.

replication_samplesize:
167 Japanese ancestry cases, 347 Japanese ancestry controls, 813 European ancestry  cases, 1071 European ancestry controls,


dbdate: 2010-04-12
author: Newman AB
date: 2010-03-18
journal: J Gerontol A Biol Sci Med Sci
link: http://www.ncbi.nlm.nih.gov/pubmed/20304771
trait: Longevity
initial_samplesize: 1,836 long-lived European ancestry individuals, 1,955 European ancestry controls
replication_samplesize: 2,594 long-lived European ancestry individuals, 3,431 European ancestry controls
region: 10q23.2
chrom: 10
reported_genes: MINPP1
mapped_gene: MINPP1 - RPS26P38
upstream_gene_id: 9562
downstream_gene_id: 100129552
strongest_risk_snp: rs9664222
strongest_risk_allele: C
snps: rs9664222
snp_id_current: 9664222
context: Intergenic
pvalue_mlog: 6.154901959985743
ci_95: [NR]
platform: Affymetrix and Illumina [2,287,520] (imputed)
cnv: N
study:
A meta-analysis of four genome-wide association studies of survival to age 90 years or older: the Cohorts for Heart and Aging Research in Genomic Epidemiology Consortium.


dbdate: 2010-03-26
author: Smith NL
date: 2010-03-15
journal: Circulation
link: http://www.ncbi.nlm.nih.gov/pubmed/20231535
trait: Coagulation factor levels
initial_samplesize: Up to 23,608 European ancestry individuals
replication_samplesize: Up to 7,604 European ancestry individuals
region: 20q11.22
chrom: 20
reported_genes: PROCR
mapped_gene: PROCR
snp_gene_ids: 10544
strongest_risk_snp: rs867186
strongest_risk_allele: G
snps: rs867186
snp_id_current: 867186
context: missense
pvalue_mlog: 36.22184874961636
platform: Affymetrix & Illumina [~2.6 million] (imputed)
cnv: N
study:
Novel associations of multiple genetic loci with plasma levels of factor VII, factor VIII, and von Willebrand factor: The CHARGE (Cohorts for Heart and Aging Research in Genome Epidemiology) Consortium.


dbdate: 2010-03-24
author: Franke A
date: 2010-03-14
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20228798
trait: Ulcerative colitis
initial_samplesize: 1,043 European ancestry cases, 1,703 European ancestry controls
replication_samplesize: 2,539 European ancestry cases, 5,428 European ancestry controls
region: 7q22.1
chrom: 7
reported_genes: SMURF1,KPNA7
mapped_gene: SMURF1 - KPNA7
upstream_gene_id: 57154
downstream_gene_id: 402569
strongest_risk_snp: rs7809799
strongest_risk_allele: G
snps: rs7809799
snp_id_current: 7809799
context: Intergenic
pvalue_mlog: 10.04575749056067
ci_95: [1.36-1.78]
platform: Affymetrix [1,897,764] (imputed)
cnv: N
study:
Genome-wide association study for ulcerative colitis identifies risk loci at 7q22 and 22q13 (IL17REL).


dbdate: 2010-03-30
author: Buil A
date: 2010-03-08
journal: Blood
link: http://www.ncbi.nlm.nih.gov/pubmed/20212171
trait: C4b binding protein levels
initial_samplesize: 352 related European ancestry individuals
region: 1q32.2
chrom: 1
reported_genes: C4BPB, C4BPA
mapped_gene: C4BPB
snp_gene_ids: 725
strongest_risk_snp: rs3813948
strongest_risk_allele: C
snps: rs3813948
snp_id_current: 3813948
context: intron
pvalue_mlog: 9.397940008672037
platform: Illumina [283,437]
cnv: N
study:
C4BPB/C4BPA is a new susceptibility locus for venous thrombosis with unknown protein S-independent mechanism: results from genome-wide association and gene expression analyses followed by case-control studies.


dbdate: 2013-09-27
author: Stein JL
date: 2010-03-01
journal: Neuroimage
link: http://www.ncbi.nlm.nih.gov/pubmed/20197096
trait: Brain structure (hippocampal volume)
region: 1p22.2
chrom: 1
reported_genes: ZNF326
mapped_gene: ZNF326 - BARHL2
upstream_gene_id: 284695
downstream_gene_id: 343472
strongest_risk_snp: rs2813746
strongest_risk_allele: C
snps: rs2813746
snp_id_current: 2813746
context: Intergenic
pvalue_mlog: 5.698970004336018
ci_95: [NR] unit increase
platform: Illumina [546,314]
cnv: N
study:
Genome-wide analysis reveals novel genes influencing temporal lobe structure with relevance to neurodegeneration in Alzheimer's disease.

initial_samplesize:
162 European ancestry Alzheimer's disease cases, 343 European ancestry amnestic mild cognitive impairment cases, 193 European ancestry healthy elderly controls


dbdate: 2013-09-27
author: Stein JL
date: 2010-03-01
journal: Neuroimage
link: http://www.ncbi.nlm.nih.gov/pubmed/20197096
trait: Brain structure (temporal lobe volume)
region: 3p22.1
chrom: 3
reported_genes: Intergenic
mapped_gene: NFU1P1 - MYRIP
upstream_gene_id: 100132681
downstream_gene_id: 25924
strongest_risk_snp: rs9832461
strongest_risk_allele: A
snps: rs9832461
snp_id_current: 9832461
context: Intergenic
pvalue_mlog: 5.397940008672037
ci_95: [NR] unit increase
platform: Illumina [546,314]
cnv: N
initial_samplesize:
173 European ancestry Alzheimer's disease cases, 361 European ancestry Mild Cognitive Impairment cases, 208 European ancestry controls


dbdate: 2010-03-25
author: Okada Y
date: 2010-02-26
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20189936
trait: Height
initial_samplesize: 19,633 Japanese ancestry individuals
region: 4p15.32
chrom: 4
reported_genes: NCAPG, LCORL
mapped_gene: FAM184B - DCAF16
upstream_gene_id: 27146
downstream_gene_id: 54876
strongest_risk_snp: rs7678436
strongest_risk_allele: A
snps: rs7678436
snp_id_current: 7678436
context: Intergenic
pvalue_mlog: 14.09691001300805
ci_95: [0.07-0.11] cm decrease
platform: Illumina [420,885]
cnv: N
study:
A genome-wide association study in 19 633 Japanese subjects identified LHX3-QSOX2 and IGF1 as adult height loci.


dbdate: 2010-03-25
author: Pillas D
date: 2010-02-26
journal: PLoS Genet
trait: Primary tooth development (number of teeth)
initial_samplesize: 5,752 European ancestry related individuals
region: 17q24.3
chrom: 17
reported_genes: KCNJ2
mapped_gene: KCNJ2 - CALM2P1
upstream_gene_id: 3759
downstream_gene_id: 100128390
strongest_risk_snp: rs8079702
strongest_risk_allele: G
snps: rs8079702
snp_id_current: 8079702
context: Intergenic
pvalue_mlog: 14
ci_95: [NR] % variance explained
platform: Illumina [300,766]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20195514?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=14

study:
Genome-wide association study reveals multiple loci associated with primary tooth development during infancy.


dbdate: 2010-03-25
author: Athanasiu L
date: 2010-02-23
journal: J Psychiatr Res
link: http://www.ncbi.nlm.nih.gov/pubmed/20185149
trait: Schizophrenia
initial_samplesize: 201 European ancestry cases, 305 European ancestry controls
replication_samplesize: 2,663 European ancestry cases, 13,780 European ancestry controls
region: 9p21.2
chrom: 9
reported_genes: PLAA
mapped_gene: PLAA
snp_gene_ids: 9373
strongest_risk_snp: rs7045881
snps: rs7045881
snp_id_current: 7045881
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [NR]
platform: Affymetrix [572,888]
cnv: N
study:
Gene variants associated with schizophrenia in a Norwegian genome-wide study are replicated in a large European cohort.


dbdate: 2010-03-17
author: Qi L
date: 2010-02-22
journal: Hum Mol Genet
trait: E-selectin levels
initial_samplesize: 501 European ancestry type 2 diabetes women cases, 504 European ancestry women controls
replication_samplesize: 518 European ancestry women
region: 9q34.2
chrom: 9
reported_genes: ABO
mapped_gene: ABO - SURF6
upstream_gene_id: 28
downstream_gene_id: 6838
strongest_risk_snp: rs651007
strongest_risk_allele: T
snps: rs651007
snp_id_current: 651007
context: Intergenic
pvalue_mlog: 81.69897000433602
ci_95: [NR] % variance explained
platform: Affymetrix [721,316]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20147318?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

study:
Genetic variants in ABO blood group region, plasma soluble E-selectin levels and risk of type 2 diabetes.


dbdate: 2010-03-17
author: Sun Q
date: 2010-02-22
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20167575
trait: Soluble leptin receptor levels
initial_samplesize: 684 European ancestry type 2 diabetes women cases, 820 European ancestry women controls
replication_samplesize: 875 European ancestry males
region: 1p31.3
chrom: 1
reported_genes: LEPR
mapped_gene: LEPR
snp_gene_ids: 3953
strongest_risk_snp: rs1751492
strongest_risk_allele: C
snps: rs1751492
snp_id_current: 1751492
context: intron
pvalue_mlog: 12.22184874961636
ci_95: [5.64-9.56] % decrease
platform: Affymetrix [2,543,887] (imputed)
cnv: N
study:
Genome-wide association study identifies polymorphisms in LEPR as determinants of plasma soluble leptin receptor levels.


dbdate: 2010-03-17
author: Cho MH
date: 2010-02-21
journal: Nat Genet
study: Variants in FAM13A are associated with chronic obstructive pulmonary disease.
trait: Chronic obstructive pulmonary disease
initial_samplesize: 2,940 European ancestry cases, 1,380 European ancestry controls
replication_samplesize: 502 European ancestry cases, 504 European ancestry controls, 1,110 cases, 2,698 controls
region: 4q22.1
chrom: 4
reported_genes: FAM13A
mapped_gene: FAM13A
snp_gene_ids: 10144
strongest_risk_snp: rs7671167
snps: rs7671167
snp_id_current: 7671167
context: intron
pvalue_mlog: 11
ci_95: [1.19-1.47]
platform: Illumina [499,578]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20173748?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2010-03-15
author: Ellinor PT
date: 2010-02-21
journal: Nat Genet
study: Common variants in KCNN3 are associated with lone atrial fibrillation.
trait: Atrial fibrillation
initial_samplesize: 1,335 European ancestry cases, 12,844 European ancestry controls
replication_samplesize: 1,164 European ancestry cases, 3,607 European ancestry controls
region: 4q25
chrom: 4
reported_genes: PITX2
mapped_gene: PITX2 - MIR297
upstream_gene_id: 5308
downstream_gene_id: 100126354
strongest_risk_snp: rs6843082
strongest_risk_allele: G
snps: rs6843082
snp_id_current: 6843082
context: Intergenic
pvalue_mlog: 27.52287874528033
ci_95: [1.79-2.30]
platform: Affymetrix and Illumina [~2.5 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20173747?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2010-03-17
author: Tsai FJ
date: 2010-02-19
journal: PLoS Genet
trait: Type 2 diabetes
initial_samplesize: 995 Han Chinese ancestry cases, 894 Han Chinese ancestry controls
replication_samplesize: 1,803 Han Chinese ancestry cases, 1,473 Han Chinese ancestry controls
region: 17p13.3
chrom: 17
reported_genes: SRR
mapped_gene: SRR
snp_gene_ids: 63826
strongest_risk_snp: rs391300
strongest_risk_allele: G
snps: rs391300
snp_id_current: 391300
context: intron
pvalue_mlog: 8.522878745280337
ci_95: [1.18-1.39]
platform: Illumina [516,737]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20174558?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

study:
A genome-wide association study identifies susceptibility variants for type 2 diabetes in Han Chinese.


dbdate: 2010-03-15
author: Barbalic M
date: 2010-02-18
journal: Hum Mol Genet
study: Large-scale genomic studies reveal central role of ABO in sP-selectin and sICAM-1 levels.
trait: Soluble levels of adhesion molecules
initial_samplesize: Up to 9,813 European ancestry individuals
region: 1q24.2
chrom: 1
reported_genes: SELP
mapped_gene: SELP
snp_gene_ids: 6403
strongest_risk_snp: rs6136
strongest_risk_allele: T
snps: rs6136
snp_id_current: 6136
context: missense
pvalue_mlog: 60.39794000867204
ci_95: [19.86-25.34] % increase
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20167578?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2010-03-12
author: Okada Y
date: 2010-02-18
journal: Hum Mol Genet
study: Common variations in PSMD3-CSF3 and PLCB4 are associated with neutrophil count.
trait: Neutrophil count
initial_samplesize: 5,771 Japanese ancestry individuals
replication_samplesize: 1,894 Japanese ancestry individuals
region: 17q21.1
chrom: 17
reported_genes: PSMD3, CSF3
mapped_gene: PSMD3 - CSF3
upstream_gene_id: 5709
downstream_gene_id: 1440
strongest_risk_snp: rs4794822
strongest_risk_allele: C
snps: rs4794822
snp_id_current: 4794822
context: Intergenic
pvalue_mlog: 9.221848749616356
ci_95: [0.07-0.13] unit decrease in log(neutrophil ct)
platform: Illumina [486,091]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20172861?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2010-03-23
author: Stein JL
date: 2010-02-17
journal: Neuroimage
study: Voxelwise genome-wide association study (vGWAS).
trait: Brain structure
initial_samplesize: 740 European ancestry individuals
region: 6q16.2
chrom: 6
reported_genes: Intergenic
mapped_gene: BDH2P1 - FAXC
upstream_gene_id: 389416
downstream_gene_id: 84553
strongest_risk_snp: rs2132683
snps: rs2132683
snp_id_current: 2132683
context: Intergenic
pvalue_mlog: 5.999999999999999
platform: Illumina [448,293]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20171287?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2013-09-25
author: Herbeck JT
date: 2010-02-15
journal: J Infect Dis
link: http://www.ncbi.nlm.nih.gov/pubmed/20064070
trait: HIV-1 progression
replication_samplesize: 590 European ancestry seroconverter males
region: 1q32.3
chrom: 1
reported_genes: PROX1
mapped_gene: PROX1-AS1
snp_gene_ids: 100505832
strongest_risk_snp: rs17762192
strongest_risk_allele: G
snps: rs17762192
snp_id_current: 17762192
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [NR]
platform: Affymetrix [345,926]
cnv: N
study:
Multistage genomewide association study identifies a locus at 1q41 associated with rate of HIV-1 disease progression to clinical AIDS.

initial_samplesize:
51 European ancestry rapid progressor males, 57 European ancestry moderate progressor males, 48 European ancestry long-term progressor males


dbdate: 2010-03-09
author: Lange LA
date: 2010-02-13
journal: Hum Mol Genet
trait: Homocysteine levels
initial_samplesize: 1,786 Filipino ancestry women
replication_samplesize: 1,679 Filipino ancestry offspring
region: 2q34
chrom: 2
reported_genes: CPS1
mapped_gene: CPS1
snp_gene_ids: 1373
strongest_risk_snp: rs7422339
strongest_risk_allele: A
snps: rs7422339
snp_id_current: 1047891
context: missense
pvalue_mlog: 8.301029995663981
ci_95: [0.03-0.07] increase in log(Hcy)
platform: Affymetrix [2,073,674] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20154341?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3

study:
Genome-wide association study of homocysteine levels in Filipinos provides evidence for CPS1 in women and a stronger MTHFR effect in young adults.


dbdate: 2010-03-07
author: Jakkula E
date: 2010-02-12
journal: Am J Hum Genet
trait: Multiple sclerosis
initial_samplesize: 68 Finland founder cases, 136 Finland founder controls
region: 17q21.2
chrom: 17
reported_genes: STAT3
mapped_gene: STAT3
snp_gene_ids: 6774
strongest_risk_snp: rs744166
strongest_risk_allele: G
snps: rs744166
snp_id_current: 744166
context: intron
pvalue_mlog: 9.522878745280336
ci_95: [1.10-1.20]
platform: Illumina [297,343]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20159113?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

study:
Genome-wide association study in a high-risk isolate for multiple sclerosis reveals associated variants in STAT3 gene.

replication_samplesize:
83 Finland founder cases, 365 Finland founder controls 3,285 European ancestry cases, 6,379 European ancestry controls, 342 Other ancestry cases, 1,679 Other ancestry controls, 860 cases, 1,720 controls


dbdate: 2010-03-06
author: Yang W
date: 2010-02-12
journal: PLoS Genet
trait: Systemic lupus erythematosus
initial_samplesize: 314 Chinese ancestry cases, 1,484 Chinese ancestry controls
region: 11q24.3
chrom: 11
reported_genes: ETS1
mapped_gene: ETS1
snp_gene_ids: 2113
strongest_risk_snp: rs1128334
strongest_risk_allele: A
snps: rs1128334
snp_id_current: 1128334
context: UTR-3
pvalue_mlog: 10.69897000433602
ci_95: [1.20-1.39]
platform: Illumina [514,221]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20169177?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2

study:
Genome-wide association study in Asian populations identifies variants in ETS1 and WDFY4 associated with systemic lupus erythematosus.

replication_samplesize:
2,630 Chinese ancestry cases, 2,155 Chinese ancestry controls, 314 Thai ancestry cases, 519 Thai ancestry controls


dbdate: 2010-03-06
author: He M
date: 2010-02-11
journal: Arterioscler Thromb Vasc Biol
trait: Interleukin-18 levels
initial_samplesize: 1,523 European ancestry women
replication_samplesize: 435 European ancestry women
region: 11q23.1
chrom: 11
reported_genes: BCO2
mapped_gene: BCO2
snp_gene_ids: 83875
strongest_risk_snp: rs2115763
strongest_risk_allele: T
snps: rs2115763
snp_id_current: 2115763
context: intron
pvalue_mlog: 8.397940008672036
platform: Affymetrix [704,409]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20150558?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=6

study:
Genome-wide association study identifies variants at the IL18-BCO2 locus associated with interleukin-18 levels.


dbdate: 2013-10-18
author: Xing C
date: 2010-02-11
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20152958
trait: Fasting plasma glucose
initial_samplesize: 2,029 African American individuals, 7,428 European ancestry individuals
replication_samplesize: 1,571 African American individuals, 3,825 European ancestry individuals
region: 20p11.21
chrom: 20
reported_genes: FOXA2
mapped_gene: FOXA2;LOC101929685
snp_gene_ids: 3170;101929685
strongest_risk_snp: rs1209523
snps: rs1209523
snp_id_current: 1209523
context: nearGene-5;intron
pvalue_mlog: 10.69897000433602
platform: Affymetrix [814,004]
cnv: N
study:
A weighted false discovery rate control procedure reveals alleles at FOXA2 that influence fasting glucose levels.


dbdate: 2010-03-06
author: Codd V
date: 2010-02-07
journal: Nat Genet
study: Common variants near TERC are associated with mean telomere length.
trait: Telomere length
initial_samplesize: 2,917 European ancestry individuals
replication_samplesize: 9,492 European ancestry individuals
region: 3q26.2
chrom: 3
reported_genes: TERC
mapped_gene: SDHDP3 - TERC
upstream_gene_id: 29771
downstream_gene_id: 7012
strongest_risk_snp: rs12696304
strongest_risk_allele: G
snps: rs12696304
snp_id_current: 12696304
context: Intergenic
pvalue_mlog: 13.39794000867204
ci_95: [0.08-0.14] unit decrease
platform: Affymetrix [405,649]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20139977?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2013-09-04
author: Kamatani Y
date: 2010-02-07
journal: Nat Genet
study: Genome-wide association study of hematological and biochemical traits in a Japanese population.
trait: Mean corpuscular hemoglobin
initial_samplesize: Up to 14,362 Japanese ancestry individuals
region: 16p13.3
chrom: 16
reported_genes: HBA2,HBA1,LUC7L,ITFG3,RGS11
mapped_gene: HBA1
snp_gene_ids: 3039
strongest_risk_snp: rs2858942
strongest_risk_allele: A
snps: rs2858942
snp_id_current: 2858942
context: nearGene-5
pvalue_mlog: 8.522878745280337
ci_95: [0.045-0.093] unit decrease
platform: Illumina [561,583]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20139978?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2012-11-13
author: Cirulli ET
date: 2010-02-03
journal: Eur J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20125193
study: Common genetic variation and performance on standardized cognitive tests.
trait: Cognitive performance
region: 1p34.3
chrom: 1
reported_genes: RP11-109P14.2
mapped_gene: ACTN4P2 - MANEAL
upstream_gene_id: 391026
downstream_gene_id: 149175
strongest_risk_snp: rs12117544
snps: rs12117544
snp_id_current: 12117544
context: Intergenic
pvalue_mlog: 5.096910013008055
platform: Illumina [up to 563,855]
cnv: N
initial_samplesize:
Up to 813 European ancestry individuals, up to 167 East Asian ancestry individuals, up to 7 Hispanic/Latin American amncestry individuals, up to 74 South Asian ancestry individuals


dbdate: 2010-03-02
author: Shi J
date: 2010-02-02
journal: Mol Psychiatry
study: Genome-wide association study of recurrent early-onset major depressive disorder.
trait: Major depressive disorder
initial_samplesize: 1,020 European ancestry cases, 1,636 European ancestry controls
region: 18q22.1
chrom: 18
reported_genes: DSEL
mapped_gene: LOC643542
snp_gene_ids: 643542
strongest_risk_snp: rs17077540
strongest_risk_allele: G
snps: rs17077540
snp_id_current: 17077540
context: intron
pvalue_mlog: 6.698970004336019
platform: Affymetrix [671,424]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20125088?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2010-03-05
author: Li X
date: 2010-02-01
journal: J Allergy Clin Immunol
study: Genome-wide association study of asthma identifies RAD50-IL13 and HLA-DR/DQ regions.
trait: Asthma
initial_samplesize: 607 European ancestry cases, 3,294 European ancestry controls
region: 5q31.1
chrom: 5
reported_genes: RAD50
mapped_gene: RAD50
snp_gene_ids: 10111
strongest_risk_snp: rs2244012
strongest_risk_allele: C
snps: rs2244012
snp_id_current: 2244012
context: intron
pvalue_mlog: 6.522878745280337
ci_95: [1.36-1.97]
platform: Illumina [292,443]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20159242?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2010-02-28
author: Petersen GM
date: 2010-01-24
journal: Nat Genet
trait: Pancreatic cancer
region: 13q22.1
chrom: 13
reported_genes: KLF5, KLF12
mapped_gene: RNY1P8 - MARK2P12
upstream_gene_id: 100873807
downstream_gene_id: 100421565
strongest_risk_snp: rs9543325
strongest_risk_allele: C
snps: rs9543325
snp_id_current: 9543325
context: Intergenic
pvalue_mlog: 10.52287874528034
ci_95: [1.18-1.35]
platform: Illumina [551,766]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20101243?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=11

study:
A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33.

initial_samplesize:
3,851 cases of European, Chinese or other ancestries, 3,934 controls of European, Chinese or other ancestries


dbdate: 2010-02-12
author: Shen L
date: 2010-01-22
journal: Neuroimage
trait: Brain imaging
region: 2q36.1[rs10932886];
reported_genes: EPHA4
strongest_risk_snp: rs10932886
snps: rs10932886
platform: Illumina [530,992]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20100581?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

study:
Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort.

initial_samplesize:
175 European ancestry Alzheimer cases, 354 European ancestry amnestic mild cognitive impairment cases, 204 European ancestry controls


dbdate: 2010-02-10
author: Kung AW
date: 2010-01-20
journal: Am J Hum Genet
trait: Bone mineral density
initial_samplesize: 785 Han Chinese ancestry extreme high and low BMD women
region: 20p12.2
chrom: 20
reported_genes: JAG1
mapped_gene: JAG1
snp_gene_ids: 182
strongest_risk_snp: rs2273061
strongest_risk_allele: A
snps: rs2273061
snp_id_current: 2273061
context: intron
pvalue_mlog: 7.30102999566398
ci_95: [NR] s.d. increase
platform: Illumina [488,853]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20096396?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=4

study:
Association of JAG1 with bone mineral density and osteoporotic fractures: a genome-wide association study and follow-up replication studies.

replication_samplesize:
264 Han Chinese ancestry High BMD individuals, 456 Han Chinese ancestry Low BMD individuals, 3,465 Han Chinese ancestry individuals, 13,913 European ancestry individuals


dbdate: 2010-02-28
author: Dupuis J
date: 2010-01-17
journal: Nat Genet
trait: Fasting glucose-related traits
initial_samplesize: up to 46,186 European descent individuals
replication_samplesize: up to 76,558 European ancestry individuals
region: 2q31.1
chrom: 2
reported_genes: G6PC2
mapped_gene: G6PC2
snp_gene_ids: 57818
strongest_risk_snp: rs560887
strongest_risk_allele: C
snps: rs560887
snp_id_current: 560887
context: intron
pvalue_mlog: 217.0457574905607
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20081858?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

study:
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk.


dbdate: 2010-02-08
author: McMahon FJ
date: 2010-01-17
journal: Nat Genet
trait: Major mood disorders
initial_samplesize: 6,686 European ancestry cases, 9,068 European ancestry controls
replication_samplesize: 1,930 European ancestry cases, 2,747 European ancestry controls
region: 3p21.1
chrom: 3
reported_genes: PBRM1
mapped_gene: PBRM1
snp_gene_ids: 55193
strongest_risk_snp: rs2251219
snps: rs2251219
snp_id_current: 2251219
context: cds-synon
pvalue_mlog: 8.698970004336019
ci_95: [1.09-1.18]
platform: Affymetrix, Illumina and Perlegen [~2.1 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20081856?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2

study:
Meta-analysis of genome-wide association data identifies a risk locus for major mood disorders on 3p21.1.


dbdate: 2010-02-08
author: Saxena R
date: 2010-01-17
journal: Nat Genet
trait: Two-hour glucose challenge
initial_samplesize: 15,234 individuals
replication_samplesize: up to 30,620 European ancestry individuals
region: 2p23.3
chrom: 2
reported_genes: GCKR
mapped_gene: GCKR
snp_gene_ids: 2646
strongest_risk_snp: rs1260326
strongest_risk_allele: T
snps: rs1260326
snp_id_current: 1260326
context: missense
pvalue_mlog: 9.522878745280336
ci_95: [0.05-0.09] mmol/L increase
platform: Affymetrix & Illumina [NR]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20081857?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3

study:
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge.


dbdate: 2010-02-05
author: Edwards TL
date: 2010-01-13
journal: Ann Hum Genet
trait: Parkinson's disease
initial_samplesize: 1,752 European ancestry cases, 1,745 European ancestry controls
region: 17q21.31
chrom: 17
reported_genes: PLEKHM1, MAPT, IMP5
mapped_gene: PLEKHM1
snp_gene_ids: 9842
strongest_risk_snp: rs11012
strongest_risk_allele: T
snps: rs11012
snp_id_current: 11012
context: ncRNA
pvalue_mlog: 7.221848749616355
ci_95: [1.27-1.61]
platform: Illumina [495,715] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20070850?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3

study:
Genome-wide association study confirms SNPs in SNCA and the MAPT region as common risk factors for Parkinson disease.


dbdate: 2010-02-04
author: Van Laer L
date: 2010-01-13
journal: Eur J Hum Genet
study: A genome-wide association study for age-related hearing impairment in the Saami.
trait: Hearing impairment
initial_samplesize: 347 Finnish Saami individuals
region: 6q22.33
chrom: 6
mapped_gene: PTPRK
snp_gene_ids: 5796
strongest_risk_snp: rs10499138
strongest_risk_allele: A
snps: rs10499138
snp_id_current: 10499138
context: intron
pvalue_mlog: 5.698970004336018
platform: Affymetrix [83,381]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20068591?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2


dbdate: 2010-02-02
author: Chung CM
date: 2010-01-12
journal: Pharmacogenomics J
trait: Angiotensin-converting enzyme activity
initial_samplesize: 400 Han Chinese ancestry hypertensive cases
replication_samplesize: 623 Han Chinese ancestry hypertensive cases
region: 17q23.3
chrom: 17
reported_genes: ACE
mapped_gene: ACE
snp_gene_ids: 1636
strongest_risk_snp: rs4343
strongest_risk_allele: G
snps: rs4343
snp_id_current: 4343
context: cds-synon
pvalue_mlog: 24.52287874528033
ci_95: [NR] % variance
platform: Illumina [~550,000]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20066004?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=4

study:
A genome-wide association study identifies new loci for ACE activity: potential implications for response to ACE inhibitor.


dbdate: 2010-01-29
author: Chambers JC
date: 2010-01-10
journal: Nat Genet
study: Genetic variation in SCN10A influences cardiac conduction.
trait: Electrocardiographic traits
initial_samplesize: 6,543 Indian Asian ancestry individuals
replication_samplesize: 6,243 Indian Asian ancestry individuals, 5,370 European ancestry individuals
region: 3p22.2
chrom: 3
reported_genes: SCN10A
mapped_gene: SCN10A
snp_gene_ids: 6336
strongest_risk_snp: rs6795970
strongest_risk_allele: A
snps: rs6795970
snp_id_current: 6795970
context: missense
pvalue_mlog: 14.52287874528034
ci_95: [2.51-4.15] ms increase
platform: Illumina [303,309]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20062061?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2


dbdate: 2010-02-02
author: Holm H
date: 2010-01-10
journal: Nat Genet
study: Several common variants modulate heart rate, PR interval and QRS duration.
trait: Electrocardiographic traits
initial_samplesize: Up to 12,670 European ancestry individuals
replication_samplesize: Up to 10,352 European ancestry individuals
region: 3p22.2
chrom: 3
reported_genes: SCN10A
mapped_gene: SCN10A
snp_gene_ids: 6336
strongest_risk_snp: rs6795970
strongest_risk_allele: A
snps: rs6795970
snp_id_current: 6795970
context: missense
pvalue_mlog: 57.99999999999999
ci_95: [13.01-16.60] % s.d. increase
platform: Illumina [306,060]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20062063?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2


dbdate: 2010-02-04
author: Pfeufer A
date: 2010-01-10
journal: Nat Genet
study: Genome-wide association study of PR interval.
trait: PR interval
initial_samplesize: 28,517 European ancestry individuals
region: 2p14
chrom: 2
reported_genes: MEIS1
mapped_gene: MEIS1
snp_gene_ids: 4211
strongest_risk_snp: rs11897119
strongest_risk_allele: C
snps: rs11897119
snp_id_current: 11897119
context: intron
pvalue_mlog: 10.30102999566398
ci_95: [0.95-1.77] ms increase
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20062060?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2010-02-02
author: Reveille JD
date: 2010-01-10
journal: Nat Genet
study: Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci.
trait: Ankylosing spondylitis
initial_samplesize: 2,053 European ancestry cases, 5,140 European ancestry controls
replication_samplesize: 898 European ancestry cases, 1,518 European ancestry controls
region: 1p31.3
chrom: 1
reported_genes: IL23R
mapped_gene: IL23R
snp_gene_ids: 149233
strongest_risk_snp: rs11209026
snps: rs11209026
snp_id_current: 11209026
context: missense
pvalue_mlog: 13.04575749056067
ci_95: [1.56-2.27]
platform: Illumina [288,662]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20062062?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2010-01-28
author: Guo Y
date: 2010-01-08
journal: PLoS Genet
study: Genome-wide association study identifies ALDH7A1 as a novel susceptibility gene for osteoporosis.
trait: Osteoporosis
initial_samplesize: 350 Han Chinese ancestry cases, 350 Han Chinese ancestry controls
replication_samplesize: 390 Han Chinese ancestry cases, 516 Han Chinsese ancestry controls
region: 5q23.2
chrom: 5
reported_genes: ALDH7A1
mapped_gene: ALDH7A1
snp_gene_ids: 501
strongest_risk_snp: rs13182402
strongest_risk_allele: G
snps: rs13182402
snp_id_current: 13182402
context: intron
pvalue_mlog: 8.698970004336019
ci_95: [1.72-2.94]
platform: Affymetrix [281,533]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20072603?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2


dbdate: 2010-01-21
author: Igl W
date: 2010-01-08
journal: PLoS Genet
trait: Cholesterol
initial_samplesize: 656 European ancestry individuals
replication_samplesize: Up to 3,282 European ancestry individuals
region: 16q13
chrom: 16
reported_genes: CETP
mapped_gene: CETP
snp_gene_ids: 1071
strongest_risk_snp: rs1532624
snps: rs1532624
snp_id_current: 1532624
context: intron
pvalue_mlog: 19.52287874528034
ci_95: [NR] mg/dl increase between hmz
platform: Illumina [~311,388]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20066028?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

study:
Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels.


dbdate: 2010-02-28
author: Kerkhof HJ
date: 2010-01-07
journal: Arthritis Rheum
trait: Osteoarthritis
initial_samplesize: 1,341 European ancestry cases, 3,496 European ancestry controls
region: 7q22.3
chrom: 7
reported_genes: COG5
mapped_gene: COG5
snp_gene_ids: 10466
strongest_risk_snp: rs3815148
strongest_risk_allele: C
snps: rs3815148
snp_id_current: 3815148
context: intron
pvalue_mlog: 7.096910013008055
ci_95: [1.09-1.19]
platform: Illumina [500,510]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20112360?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

study:
A genome-wide association study identifies an osteoarthritis susceptibility locus on chromosome 7q22.

replication_samplesize:
9,779 European ancestry cases, up to 31,818 European ancestry controls, 1,861 Other ancestry cases, 5,536 Other ancestry controls, 1,957 cases, 1,742 controls


dbdate: 2010-01-21
author: Rauch A
date: 2010-01-07
journal: Gastroenterology
trait: Chronic hepatitis C infection
region: 19q13.2
chrom: 19
reported_genes: IL28B, IL28A, IL29
mapped_gene: IFNL4 - MSRB1P1
upstream_gene_id: 101180976
downstream_gene_id: 441849
strongest_risk_snp: rs8099917
strongest_risk_allele: G
snps: rs8099917
snp_id_current: 8099917
context: Intergenic
pvalue_mlog: 8.221848749616356
ci_95: [1.74-3.06]
platform: Illumina [~500,000]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20060832?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=4

study:
Genetic variation in IL28B is associated with chronic hepatitis C and treatment failure: a genome-wide association study.

initial_samplesize:
1,015 European ancestry chronic HCV carriers, 347 European ancestry spontaneously cleared HCV individuals


dbdate: 2010-03-17
author: Liu X
date: 2010-01-01
journal: J Am Acad Child Adolesc Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/20215924
study: A genome-wide association study of amygdala activation in youths with and without bipolar disorder.
trait: Functional MRI
region: 20q13.2
chrom: 20
reported_genes: DOK5
mapped_gene: DOK5
snp_gene_ids: 55816
strongest_risk_snp: rs2023454
snps: rs2023454
snp_id_current: 2023454
context: UTR-3
pvalue_mlog: 6.30102999566398
ci_95: [NR] % variance explained
platform: Illumina [104,043]
cnv: N
initial_samplesize:
36 European ancestry BD cases, 1 African American BD case, 2 Other ancestry BD cases, 21 European ancestry controls, 5 African American controls, 3 Other ancestry controls


dbdate: 2010-01-19
author: Shrestha S
date: 2010-01-01
journal: AIDS
study: A genome-wide association study of carotid atherosclerosis in HIV-infected men.
trait: Carotid atherosclerosis in HIV infection
initial_samplesize: 177 European ancestry individuals
region: 7q31.33
chrom: 7
reported_genes: GRM8
mapped_gene: GRM8
snp_gene_ids: 2918
strongest_risk_snp: rs17691394
strongest_risk_allele: G
snps: rs17691394
snp_id_current: 17691394
context: intron
pvalue_mlog: 6.045757490560675
platform: Illumina [311,194]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20009918?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=4


dbdate: 2010-08-30
author: Ferreira MA
date: 2009-12-31
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20045101
trait: CD4:CD8 lymphocyte ratio
initial_samplesize: 2,538 European ancestry twins from 1,089 families
replication_samplesize: 988 individuals from 550 families
region: 6p21.33
chrom: 6
reported_genes: HLA-B
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs2524054
strongest_risk_allele: A
snps: rs2524054
snp_id_current: 2524054
pvalue_mlog: 27.69897000433602
ci_95: [0.31-0.43] SD increase
platform: Illumina [529,721]
cnv: N
study:
Quantitative trait loci for CD4:CD8 lymphocyte ratio are associated with risk of type 1 diabetes and HIV-1 immune control.


dbdate: 2010-01-19
author: Shyn SI
date: 2009-12-29
journal: Mol Psychiatry
trait: Major depressive disorder (broad)
initial_samplesize: 3,957 European ancestry cases, 3,428 European ancestry controls
region: 8p21.3
chrom: 8
reported_genes: ATP6V1B2, SLC18A1, LZTS1
mapped_gene: ATP6V1B2
snp_gene_ids: 526
strongest_risk_snp: rs1106634
strongest_risk_allele: A
snps: rs1106634
snp_id_current: 1106634
context: intron
pvalue_mlog: 6.154901959985743
ci_95: [NR]
platform: Affymetrix and Perlegen [2,391,203] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20038947?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

study:
Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.


dbdate: 2010-01-19
author: Fellay J
date: 2009-12-24
journal: PLoS Genet
study: Common genetic variation and the control of HIV-1 in humans.
trait: HIV-1 control
initial_samplesize: 2,362 European ancestry cases
region: 6p21.33
chrom: 6
reported_genes: HCP5, HLA-B
mapped_gene: HCP5
snp_gene_ids: 10866
strongest_risk_snp: rs2395029
strongest_risk_allele: G
snps: rs2395029
snp_id_current: 2395029
context: ncRNA
pvalue_mlog: 34.30102999566398
ci_95: [NR] % increase
platform: Illumina [NR]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20041166?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2010-01-13
author: Sleiman PM
date: 2009-12-23
journal: N Engl J Med
study: Variants of DENND1B associated with asthma in children.
trait: Asthma
initial_samplesize: 793 European ancestry cases, 1,988 European ancestry controls
region: 1q31.3
chrom: 1
reported_genes: DENND1B, CRB1
mapped_gene: CRB1
snp_gene_ids: 23418
strongest_risk_snp: rs2786098
snps: rs2786098
snp_id_current: 2786098
context: intron
pvalue_mlog: 12.69897000433602
ci_95: [NR] (European ancestry)
platform: Illumina [~550,000]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20032318?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

replication_samplesize:
917 European ancestry cases, 1,546 European ancestry controls, 1,667 African American cases, 2,045 African American controls


dbdate: 2009-12-28
author: Mangold E
date: 2009-12-20
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20023658
trait: Orofacial clefts
initial_samplesize: 399 European ancestry cases, 1,318 European ancestry controls
replication_samplesize: 655 European ancestry triads
region: 17q22
chrom: 17
reported_genes: NOG
mapped_gene: NOG - C17orf67
upstream_gene_id: 9241
downstream_gene_id: 339210
strongest_risk_snp: rs227731
strongest_risk_allele: C
snps: rs227731
snp_id_current: 227731
context: Intergenic
pvalue_mlog: 8
ci_95: [1.21-1.56]
platform: Illumina [521,288]
cnv: N
study:
Genome-wide association study identifies two susceptibility loci for nonsyndromic cleft lip with or without cleft palate.


dbdate: 2013-11-09
author: Solovieff N
date: 2009-12-16
journal: Blood
link: http://www.ncbi.nlm.nih.gov/pubmed/20018918
trait: Fetal hemoglobin levels
initial_samplesize: 848 Black cases
replication_samplesize: 305 Black cases, 406 Chinese ancestry cases, 113 Thai ancestry cases
region: 2p16.1
chrom: 2
reported_genes: BCL11A
mapped_gene: BCL11A
snp_gene_ids: 53335
strongest_risk_snp: rs766432
strongest_risk_allele: C
snps: rs766432
snp_id_current: 766432
context: intron
pvalue_mlog: 28.99999999999999
ci_95: [NR] unit increase
platform: Illumina [~600,000]
cnv: N
study:
Fetal hemoglobin in sickle cell anemia: genome-wide association studies suggest a regulatory region in the 5' olfactory receptor gene cluster.


dbdate: 2009-12-28
author: Zhang FR
date: 2009-12-16
journal: N Engl J Med
study: Genomewide association study of leprosy.
trait: Leprosy
initial_samplesize: 706 Han Chinese ancestry cases, 1,225 Han Chinese ancestry controls
replication_samplesize: 3,254 Chinese ancestry cases, 5,955 Chinese ancestry controls
region: 6p21.32
reported_genes: HLA-DR-DQ
strongest_risk_snp: rs602875
strongest_risk_allele: A
snps: rs602875
ci_95: [1.39-1.61]
platform: Illumina [491,883]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20018961?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2010-01-13
author: Hancock DB
date: 2009-12-13
journal: Nat Genet
trait: Pulmonary function
initial_samplesize: 20,890 European ancestry individuals
replication_samplesize: 16,178 European ancestry individuals
region: 4q31.21
chrom: 4
reported_genes: HHIP
mapped_gene: GYPA - KRT18P51
upstream_gene_id: 2993
downstream_gene_id: 391703
strongest_risk_snp: rs1980057
strongest_risk_allele: T
snps: rs1980057
snp_id_current: 1980057
context: Intergenic
pvalue_mlog: 19.52287874528034
ci_95: [NR] % increase
platform: Affymetrix & Illumina [2,534,500] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20010835?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=5

study:
Meta-analyses of genome-wide association studies identify multiple loci associated with pulmonary function.


dbdate: 2009-12-28
author: Repapi E
date: 2009-12-13
journal: Nat Genet
study: Genome-wide association study identifies five loci associated with lung function.
trait: Pulmonary function
initial_samplesize: 20,288 European ancestry individuals
replication_samplesize: up to 54,276 European ancestry individuals
region: 2q35
chrom: 2
reported_genes: TNS1
mapped_gene: TNS1
snp_gene_ids: 7145
strongest_risk_snp: rs2571445
strongest_risk_allele: G
snps: rs2571445
snp_id_current: 2571445
context: missense
pvalue_mlog: 12
ci_95: [NR] % variance explained
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20010834?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2009-12-28
author: Castro-Giner F
date: 2009-12-06
journal: BMC Med Genet
trait: Atopy
replication_samplesize: 429 European ancestry atopy cases, 222 European ancestry controls
region: 2p21
chrom: 2
reported_genes: SGK493
mapped_gene: PKDCC
snp_gene_ids: 91461
strongest_risk_snp: rs4952590
snps: rs4952590
snp_id_current: 4952590
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [1.27-2.86]
platform: Illumina [NR] (pooled)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19961619?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2

study:
A pooling-based genome-wide analysis identifies new potential candidate genes for atopy in the European Community Respiratory Health Survey (ECRHS).

initial_samplesize:
75 European ancestry atopy and asthma cases, 75 European ancestry atopy only cases, 75 European ancestry controls


dbdate: 2009-12-28
author: Wallace C
date: 2009-12-06
journal: Nat Genet
study: The imprinted DLK1-MEG3 gene region on chromosome 14q32.2 alters susceptibility to type 1 diabetes.
trait: Type 1 diabetes
initial_samplesize: 7,514 European ancestry cases, 9,045 European ancestry controls
region: 19p13.2
chrom: 19
reported_genes: TYK2
mapped_gene: TYK2
snp_gene_ids: 7297
strongest_risk_snp: rs2304256
strongest_risk_allele: C
snps: rs2304256
snp_id_current: 2304256
context: missense
pvalue_mlog: 8.397940008672036
ci_95: [1.11-1.22]
platform: Affymetrix & Illumina [~2.6 million](imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19966805?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=7

replication_samplesize:
4,840 European ancestry cases, 2,670 European ancestry controls, 5,766 European ancestry familial triads


dbdate: 2010-01-07
author: Richards JB
date: 2009-12-05
journal: PLoS Genet
study: A genome-wide association study reveals variants in ARL15 that influence adiponectin levels.
trait: Adiponectin levels
initial_samplesize: 8,531 European ancestry individuals
replication_samplesize: 6,202 European ancestry individuals
region: 5q11.2
chrom: 5
reported_genes: ARL15
mapped_gene: ARL15
snp_gene_ids: 54622
strongest_risk_snp: rs4311394
strongest_risk_allele: G
snps: rs4311394
snp_id_current: 4311394
context: intron
pvalue_mlog: 7.522878745280337
ci_95: [NR] ug/ml increase
platform: Affymetrix & Illumina [~2.2 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20011104?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2


dbdate: 2010-01-13
author: Heid IM
date: 2009-12-02
journal: Atherosclerosis
trait: Adiponectin levels
initial_samplesize: 4,659 European ancestry individuals
replication_samplesize: 13,795 European ancestry individuals
region: 3q27.3
chrom: 3
reported_genes: ADIPOQ
mapped_gene: ADIPOQ;ADIPOQ-AS1
snp_gene_ids: 9370;100874095
strongest_risk_snp: rs17366568
strongest_risk_allele: G
snps: rs17366568
snp_id_current: 17366568
context: intron;ncRNA
pvalue_mlog: 41
ci_95: [NR] log(ug/ml) increase
platform: Affymetrix and Illumina [2,585,854] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20018283?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

study:
Clear detection of ADIPOQ locus as the major gene for plasma adiponectin: results of genome-wide association analyses including 4659 European individuals.


dbdate: 2013-09-24
author: Chasman DI
date: 2009-11-20
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19936222
trait: Lipid metabolism phenotypes
initial_samplesize: Up to 17,296 European ancestry women
region: 2p21
chrom: 2
reported_genes: ABCG5,ABCG8
mapped_gene: ABCG8
snp_gene_ids: 64241
strongest_risk_snp: rs4299376
snps: rs4299376
snp_id_current: 4299376
context: intron
pvalue_mlog: 7.698970004336018
ci_95: [NR] unit increase
platform: Illumina [335,603]
cnv: N
study:
Forty-three loci associated with plasma lipoprotein size, concentration, and cholesterol content in genome-wide analysis.

replication_samplesize:
Up to 2,700 individuals, Up to 2,000 European ancestry cardiovascular heart disease cases and controls


dbdate: 2009-12-28
author: Nuinoon M
date: 2009-11-19
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20183929
trait: Beta thalassemia/hemoglobin E disease
initial_samplesize: 235 mild Thai-Chinese ancesry cases, 383 severe Thai-Chinese ancestry cases
replication_samplesize: 52 mild Indonesian ancestry cases, 122 severe Indonesian ancestry cases
region: 2p16.1
chrom: 2
reported_genes: BCL11A
mapped_gene: BCL11A
snp_gene_ids: 53335
strongest_risk_snp: rs766432
snps: rs766432
snp_id_current: 766432
context: intron
pvalue_mlog: 10
ci_95: [2.04-3.84]
platform: Illumina [548,094]
cnv: N
study:
A genome-wide association identified the common genetic variants influence disease severity in beta0-thalassemia/hemoglobin E.


dbdate: 2009-12-14
author: Asano K
date: 2009-11-15
journal: Nat Genet
trait: Ulcerative colitis
initial_samplesize: 376 Japanese ancestry cases, 934 Japanese ancestry controls
replication_samplesize: 376 Japanese ancestry cases, 1,097 Japanese ancestry controls
region: 6p21.33
chrom: 6
reported_genes: HLA
mapped_gene: CCHCR1
snp_gene_ids: 54535
strongest_risk_snp: rs9263739
strongest_risk_allele: T
snps: rs9263739
snp_id_current: 9263739
context: intron
pvalue_mlog: 66.39794000867204
ci_95: [2.43-3.07]
platform: Illumina [513,923]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19915573?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3

study:
A genome-wide association study identifies three new susceptibility loci for ulcerative colitis in the Japanese population.


dbdate: 2009-12-11
author: Barrett JC
date: 2009-11-15
journal: Nat Genet
trait: Ulcerative colitis
initial_samplesize: 2,361 European ancestry cases, 5,417 European ancestry controls
replication_samplesize: 2,321 European ancestry cases, 4,818 European ancestry controls
region: 7q31.1
chrom: 7
reported_genes: LAMB1
mapped_gene: PIGCP2 - DLD
upstream_gene_id: 100128307
downstream_gene_id: 1738
strongest_risk_snp: rs886774
strongest_risk_allele: G
snps: rs886774
snp_id_current: 886774
context: Intergenic
pvalue_mlog: 7.522878745280337
ci_95: [1.03-1.19]
platform: Affymetrix [NR]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19915572?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

study:
Genome-wide association study of ulcerative colitis identifies three new susceptibility loci, including the HNF4A region.


dbdate: 2009-12-10
author: Imielinski M
date: 2009-11-15
journal: Nat Genet
study: Common variants at five new loci associated with early-onset inflammatory bowel disease.
trait: Inflammatory bowel disease (early onset)
initial_samplesize: 2,413 European ancestry cases, 6,158 European ancestry controls
replication_samplesize: 1,013 European ancestry cases, 5,805 European ancestry controls
region: 19q13.11
chrom: 19
reported_genes: Intergenic
mapped_gene: SLC7A10 - CEBPA
upstream_gene_id: 56301
downstream_gene_id: 1050
strongest_risk_snp: rs10500264
snps: rs10500264
snp_id_current: 10500264
context: Intergenic
pvalue_mlog: 9.397940008672037
ci_95: [1.11-1.31]
platform: Illumina [~500,000]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19915574?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2009-12-10
author: Satake W
date: 2009-11-15
journal: Nat Genet
trait: Parkinson's disease
initial_samplesize: 988 Japanese ancestry cases, 2,521 Japanese ancestry controls
replication_samplesize: 933 Japanese ancestry cases, 15,753 Japanese ancestry controls
region: 1q32.1
chrom: 1
reported_genes: PARK16, SLC45A3, NUCKS1, RAB7L1, SLC41A1, PM20D1
mapped_gene: RAB7L1 - SLC41A1
upstream_gene_id: 8934
downstream_gene_id: 254428
strongest_risk_snp: rs947211
snps: rs947211
snp_id_current: 947211
context: Intergenic
pvalue_mlog: 11.69897000433602
ci_95: [1.21-1.39]
platform: Illumina [435,470]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19915576?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

study:
Genome-wide association study identifies common variants at four loci as genetic risk factors for Parkinson's disease.


dbdate: 2009-12-10
author: Simon-Sanchez J
date: 2009-11-15
journal: Nat Genet
study: Genome-wide association study reveals genetic risk underlying Parkinson's disease.
trait: Parkinson's disease
initial_samplesize: 1,713 European ancestry cases, 3,978 European ancestry controls
replication_samplesize: 3,361 European ancestry cases, 4,573 European ancestry controls
region: 17q21.31
chrom: 17
reported_genes: MAPT, C17orf69, KIAA1267, LOC644246
mapped_gene: CRHR1;CRHR1-IT1
snp_gene_ids: 1394;147081
strongest_risk_snp: rs393152
strongest_risk_allele: A
snps: rs393152
snp_id_current: 393152
context: intron;intron
pvalue_mlog: 15.69897000433602
ci_95: [NR]
platform: Illumina [463,185]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19915575?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2013-09-24
author: Trevino LR
date: 2009-11-09
journal: J Clin Oncol
link: http://www.ncbi.nlm.nih.gov/pubmed/19901119
trait: Methotrexate phramacokinetics (acute lymphoblastic leukemia)
region: 10q22.3
chrom: 10
reported_genes: C10orf11
mapped_gene: C10orf11
snp_gene_ids: 83938
strongest_risk_snp: rs10740455
strongest_risk_allele: A
snps: rs10740455
snp_id_current: 10740455
context: intron
pvalue_mlog: 5.154901959985742
platform: Affymetrix [398,699]
cnv: N
study:
Germline genetic variation in an organic anion transporter polypeptide associated with methotrexate pharmacokinetics and clinical effects.

initial_samplesize:
315 European ancestry cases; 73 African American cases; 41 Other ancestry cases, 5 Asian unspecified cases; 206 cases


dbdate: 2009-12-04
author: Schaefer AS
date: 2009-11-06
journal: Hum Mol Genet
study: A genome-wide association study identifies GLT6D1 as a susceptibility locus for periodontitis.
trait: Periodontitis
initial_samplesize: 283 European ancestry cases, 972 European ancestry controls
replication_samplesize: 155 European ancestry cases, 341 European ancestry controls
region: 9q34.3
chrom: 9
reported_genes: GLT6D1
mapped_gene: GLT6D1
snp_gene_ids: 360203
strongest_risk_snp: rs1537415
strongest_risk_allele: G
snps: rs1537415
snp_id_current: 1537415
context: intron
pvalue_mlog: 8.221848749616356
ci_95: [1.36-1.86]
platform: Affymetrix [345,646]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19897590?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=3


dbdate: 2009-12-03
author: Birlea SA
date: 2009-11-05
journal: J Invest Dermatol
trait: Vitiligo
initial_samplesize: 32 Romanian founder cases, 44 European ancestry controls
region: 6q27
chrom: 6
reported_genes: SMOC2
mapped_gene: SMOC2
snp_gene_ids: 64094
strongest_risk_snp: rs13208776
snps: rs13208776
snp_id_current: 13208776
context: intron
pvalue_mlog: 7.045757490560674
platform: Illumina [297,342]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19890347?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

study:
Genome-wide association study of generalized vitiligo in an isolated European founder population identifies SMOC2, in close proximity to IDDM8.


dbdate: 2009-12-04
author: Medland SE
date: 2009-11-04
journal: Am J Hum Genet
study: Common variants in the trichohyalin gene are associated with straight hair in Europeans.
trait: Hair morphology
initial_samplesize: 4,845 European ancestry individuals from 2,892 families, 16,140 European ancestry individuals
region: 1q21.3
chrom: 1
reported_genes: TCHH
mapped_gene: TCHH
snp_gene_ids: 7062
strongest_risk_snp: rs11803731
strongest_risk_allele: A
snps: rs11803731
snp_id_current: 11803731
context: missense
pvalue_mlog: 30.52287874528034
ci_95: [NR] % variance
platform: Illumina [~1 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19896111?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2


dbdate: 2009-12-01
author: Tanaka T
date: 2009-10-30
journal: Blood
study: A genome-wide association analysis of serum iron concentrations.
trait: Iron levels
initial_samplesize: 1,919 European ancestry individuals
replication_samplesize: 569 females
region: 22q12.3
chrom: 22
reported_genes: TMPRSS6
mapped_gene: TMPRSS6
snp_gene_ids: 164656
strongest_risk_snp: rs4820268
strongest_risk_allele: A
snps: rs4820268
snp_id_current: 4820268
context: cds-synon
pvalue_mlog: 8.301029995663981
ci_95: [2.90-5.88] ug/dL increase
platform: Illumina [475,322]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19880490?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2009-12-01
author: Guo Y
date: 2009-10-29
journal: J Bone Miner Res
trait: Bone mineral density
initial_samplesize: 983 European ancestry individuals
replication_samplesize: 2,557 European ancestry individuals from 750 families
region: 11p15.2
chrom: 11
reported_genes: PTH
mapped_gene: PTH - HMGN2P36
upstream_gene_id: 5741
downstream_gene_id: 100874480
strongest_risk_snp: rs9630182
strongest_risk_allele: T
snps: rs9630182
snp_id_current: 9630182
context: Intergenic
pvalue_mlog: 6.397940008672037
ci_95: [NR] s.d. increase
platform: Affymetrix [342,854]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19874204?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

study:
IL21R and PTH may underlie variation of femoral neck bone mineral density as revealed by a genome-wide association study.


dbdate: 2009-11-30
author: Aberg K
date: 2009-10-27
journal: Biol Psychiatry
study: Genomewide association study of movement-related adverse antipsychotic effects.
trait: Response to antipsychotic therapy (extrapyramidal side effects)
region: 2p12
chrom: 2
reported_genes: Intergenic
mapped_gene: LRRTM1 - MTND4P25
upstream_gene_id: 347730
downstream_gene_id: 100873246
strongest_risk_snp: rs17022444
snps: rs17022444
snp_id_current: 17022444
context: Intergenic
pvalue_mlog: 10
platform: Affymetrix [492,000]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19875103?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2

initial_samplesize:
421 European ancestry schizophrenia cases, 214 African American schizophrenia cases, 103 Other ancestry schizophrenia cases


dbdate: 2009-11-18
author: Johansson A
date: 2009-10-22
journal: Obesity (Silver Spring)
trait: Body mass index
region: 1p36.33
chrom: 1
mapped_gene: AGRN - RNF223
upstream_gene_id: 375790
downstream_gene_id: 401934
strongest_risk_snp: rs3934834
strongest_risk_allele: G
snps: rs3934834
snp_id_current: 3934834
context: Intergenic
pvalue_mlog: 6.221848749616355
ci_95: [NR] kg increase
platform: Illumina [318,237]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19851299?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=4

study:
Linkage and genome-wide association analysis of obesity-related phenotypes: association of weight with the MGAT1 gene.

initial_samplesize:
1,079 South Tyrolian individuals, 790 Dutch founder individuals, 2,060 European ancestry individuals


dbdate: 2009-11-25
author: Garriock HA
date: 2009-10-19
journal: Biol Psychiatry
study: A genomewide association study of citalopram response in major depressive disorder.
trait: Response to citalopram treatment
region: 7q36.3
chrom: 7
reported_genes: UBE3C
mapped_gene: MNX1-AS1 - UBE3C
upstream_gene_id: 645249
downstream_gene_id: 9690
strongest_risk_snp: rs6966038
snps: rs6966038
snp_id_current: 6966038
context: Intergenic
pvalue_mlog: 6.30102999566398
ci_95: [1.35-1.99]
platform: Affymetrix [430,198]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19846067?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1

initial_samplesize:
Up to 659 European ancestry responders, up to 121 African American responders, up to 103 Hispanic responders, 408 European ancestry non-responders, 120 African American non-responders, 80 Hispanic non-responders


dbdate: 2009-11-09
author: Han JW
date: 2009-10-18
journal: Nat Genet
trait: Systemic lupus erythematosus
initial_samplesize: 1,047 Han Chinese ancestry cases, 1,205 Han Chinese ancestry controls
replication_samplesize: 3,152 Han Chinese ancestry cases, 7,050 Han Chinese ancestry controls
region: 1q25.1
chrom: 1
reported_genes: TNFSF4
mapped_gene: TNFSF4 - RPL26P11
upstream_gene_id: 7292
downstream_gene_id: 730070
strongest_risk_snp: rs2205960
strongest_risk_allele: A
snps: rs2205960
snp_id_current: 2205960
context: Intergenic
pvalue_mlog: 31.52287874528033
ci_95: [1.37-1.56]
platform: Illumina [493,955]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19838193?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2

study:
Genome-wide association study in a Chinese Han population identifies nine new susceptibility loci for systemic lupus erythematosus.


dbdate: 2009-11-09
author: Landi MT
date: 2009-10-15
journal: Am J Hum Genet
trait: Lung adenocarcinoma
initial_samplesize: 5,739 European ancestry cases, 5,848 European ancestry controls
replication_samplesize: 7,561 European ancestry cases, 13,818 European ancestry controls
region: 5p15.33
chrom: 5
reported_genes: TERT
mapped_gene: TERT
snp_gene_ids: 7015
strongest_risk_snp: rs2736100
strongest_risk_allele: G
snps: rs2736100
snp_id_current: 2736100
context: intron
pvalue_mlog: 9.698970004336017
ci_95: [1.08-1.16]
platform: Illumina [515,922]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19836008?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=5

study:
A genome-wide association study of lung cancer identifies a region of chromosome 5p15 associated with risk for adenocarcinoma.


dbdate: 2009-11-05
author: Benyamin B
date: 2009-10-11
journal: Nat Genet
study: Common variants in TMPRSS6 are associated with iron status and erythrocyte volume.
trait: Iron status biomarkers
initial_samplesize: 4,818 European ancestry individuals
replication_samplesize: 3,470 European ancestry individuals
region: 22q12.3
chrom: 22
reported_genes: TMPRSS6
mapped_gene: TMPRSS6
snp_gene_ids: 164656
strongest_risk_snp: rs855791
strongest_risk_allele: T
snps: rs855791
snp_id_current: 855791
context: missense
pvalue_mlog: 6.30102999566398
ci_95: [0.06-0.14] s.d. decrease
platform: Illumina & Perlegen [427,037]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19820699?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-11-05
author: Chambers JC
date: 2009-10-11
journal: Nat Genet
study: Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels.
trait: Hemoglobin
initial_samplesize: 6,316 European ancestry individuals, 9,685 Indian Asian ancestry individuals
replication_samplesize: 5,187 European ancestry individuals, 6,721 Indian Asian ancestry individuals
region: 22q12.3
chrom: 22
reported_genes: TMPRSS6
mapped_gene: TMPRSS6
snp_gene_ids: 164656
strongest_risk_snp: rs855791
strongest_risk_allele: A
snps: rs855791
snp_id_current: 855791
context: missense
pvalue_mlog: 12.69897000433602
ci_95: [0.09-0.17] g/dl decrease
platform: Affymetrix, Illumina & Perlegen [NR]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19820698?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-11-03
author: Ganesh SK
date: 2009-10-11
journal: Nat Genet
study: Multiple loci influence erythrocyte phenotypes in the CHARGE Consortium.
trait: Hematocrit
initial_samplesize: 24,167 European ancestry individuals
replication_samplesize: 9,456 European ancestry individuals
region: 6p22.2
chrom: 6
reported_genes: HFE
mapped_gene: HFE
snp_gene_ids: 3077
strongest_risk_snp: rs1800562
strongest_risk_allele: A
snps: rs1800562
snp_id_current: 1800562
context: missense
pvalue_mlog: 8.698970004336019
ci_95: [0.21-0.41] % increase
platform: Affymetrix & Illumina [~2.5 million](imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19862010?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=1


dbdate: 2009-10-30
author: Soranzo N
date: 2009-10-11
journal: Nat Genet
trait: Hematological parameters
initial_samplesize: 4,627 European ancestry individuals
replication_samplesize: 9,316 European ancestry individuals
region: 22q12.3
chrom: 22
reported_genes: TMPRSS6
mapped_gene: TMPRSS6
snp_gene_ids: 164656
strongest_risk_snp: rs5756506
strongest_risk_allele: C
snps: rs5756506
snp_id_current: 5756506
context: intron
pvalue_mlog: 8.999999999999998
ci_95: [0.10-0.18] pg increase
platform: Affymetrix and Illumina [~2.11 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19820697?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
A genome-wide meta-analysis identifies 22 loci associated with eight hematological parameters in the HaemGen consortium.


dbdate: 2009-10-23
author: Weiss LA
date: 2009-10-08
journal: Nature
study: A genome-wide linkage and association scan reveals novel loci for autism.
trait: Autism
initial_samplesize: 1,553 probands from 1,031 families
replication_samplesize: 2,073 trios
region: 5p15.31
chrom: 5
reported_genes: SEMA5A, TAS2R1
mapped_gene: SNORD123 - TAS2R1
upstream_gene_id: 100113384
downstream_gene_id: 50834
strongest_risk_snp: rs10513025
snps: rs10513025
snp_id_current: 10513025
context: Intergenic
pvalue_mlog: 6.522878745280337
ci_95: [NR]
platform: Affymetrix [~365,000]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19812673?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-10-16
author: Rivadeneira F
date: 2009-10-04
journal: Nat Genet
trait: Bone mineral density (hip)
initial_samplesize: 19,195 European ancestry individuals
region: 1p31.3
chrom: 1
reported_genes: GPR177
mapped_gene: WLS;GNG12-AS1
snp_gene_ids: 79971;100289178
strongest_risk_snp: rs2566755
strongest_risk_allele: C
snps: rs2566755
snp_id_current: 2566755
context: intron;intron
pvalue_mlog: 11.69897000433602
ci_95: [0.07-0.13] s.d. increase
platform: Affymetrix & Illumina [2,543,686](imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19801982?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.


dbdate: 2009-11-04
author: Hicks AA
date: 2009-10-02
journal: PLoS Genet
study: Genetic determinants of circulating sphingolipid concentrations in European populations.
trait: Sphingolipid levels
initial_samplesize: 4,110 European ancestry individuals
region: 4p12
chrom: 4
reported_genes: ATP10D
mapped_gene: ATP10D
snp_gene_ids: 57205
strongest_risk_snp: rs10938494
strongest_risk_allele: A
snps: rs10938494
snp_id_current: 10938494
context: intron
pvalue_mlog: 18.09691001300805
ci_95: [0.04-0.07] unit increase
platform: Illumina [318,237]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19798445?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-10-06
author: Roeske D
date: 2009-09-29
journal: Mol Psychiatry
trait: Speech perception in dyslexia
initial_samplesize: 200 European ancestry cases
replication_samplesize: 186 European ancestry cases
region: 4q32.1
chrom: 4
reported_genes: CTSO, TDO2, PDGFC
mapped_gene: FTH1P21 - PDGFC
upstream_gene_id: 2510
downstream_gene_id: 56034
strongest_risk_snp: rs4234898
strongest_risk_allele: T
snps: rs4234898
snp_id_current: 4234898
context: Intergenic
pvalue_mlog: 7.30102999566398
platform: Illumina [297,086]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19786962?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
First genome-wide association scan on neurophysiological endophenotypes points to trans-regulation effects on SLC2A3 in dyslexic children.


dbdate: 2009-10-06
author: Nakanishi H
date: 2009-09-25
journal: PLoS Genet
trait: Myopia (pathological)
initial_samplesize: 297 Japanese ancestry cases, 934 Japanese ancestry controls
replication_samplesize: 533 Japanese ancestry cases, 977 Japanese ancestry controls
region: 11q24.1
chrom: 11
reported_genes: BLID, LOC399959
mapped_gene: MIR100HG
snp_gene_ids: 399959
strongest_risk_snp: rs577948
strongest_risk_allele: G
snps: rs577948
snp_id_current: 577948
context: intron
pvalue_mlog: 6.698970004336019
ci_95: [1.21-1.54]
platform: Illumina [411,777]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19779542?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
A genome-wide association analysis identified a novel susceptible locus for pathological myopia at 11q24.1.


dbdate: 2009-10-05
author: Latourelle JC
date: 2009-09-22
journal: BMC Med Genet
study: Genomewide association study for onset age in Parkinson disease.
trait: Parkinson's disease (age of onset)
initial_samplesize: 857 European ancestry familial cases, 440 idiopathic cases
replication_samplesize: 747 European ancestry idiopathic cases
region: 15q12
chrom: 15
reported_genes: OCA2
mapped_gene: GABRG3 - OCA2
upstream_gene_id: 2567
downstream_gene_id: 4948
strongest_risk_snp: rs17565841
strongest_risk_allele: A
snps: rs17565841
snp_id_current: 17565841
context: Intergenic
pvalue_mlog: 5.522878745280337
ci_95: [NR] years younger
platform: Illumina and Perlegen [1,861,750] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19772629?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-12-29
author: Eeles RA
date: 2009-09-20
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19767753
trait: Prostate cancer
initial_samplesize: 1,854 European ancestry cases, 1,894 European ancestry controls
region: 2p21
chrom: 2
reported_genes: THADA
mapped_gene: THADA
snp_gene_ids: 63892
strongest_risk_snp: rs1465618
snps: rs1465618
snp_id_current: 1465618
context: intron
pvalue_mlog: 7.698970004336018
ci_95: [1.03-1.12]
platform: Illumina [541,129]
cnv: N
study:
Identification of seven new prostate cancer susceptibility loci through a genome-wide association study.

replication_samplesize:
19,879 cases and 18,761 controls of European, East Asian, African American, Latino, and Hawaiian ancestry


dbdate: 2009-10-05
author: Gudmundsson J
date: 2009-09-20
journal: Nat Genet
trait: Prostate cancer
initial_samplesize: Up to 1,968 European ancestry cases, 35,382 European ancestry controls
replication_samplesize: Up to 11,806 European ancestry cases, 12,387 European ancestry controls
region: 3q21.3
chrom: 3
reported_genes: Intergenic
mapped_gene: EEFSEC
snp_gene_ids: 60678
strongest_risk_snp: rs10934853
strongest_risk_allele: A
snps: rs10934853
snp_id_current: 10934853
context: intron
pvalue_mlog: 9.522878745280336
ci_95: [1.08-1.16]
platform: Illumina [310,520]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19767754?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association and replication studies identify four variants associated with prostate cancer susceptibility.


dbdate: 2009-09-30
author: Le Clerc S
date: 2009-09-15
journal: J Infect Dis
trait: AIDS
initial_samplesize: 85 European ancestry cases, 2,049 European ancestry controls
region: 1p13.3
chrom: 1
reported_genes: Intergenic
mapped_gene: NDE1P1 - PRMT6
upstream_gene_id: 100422372
downstream_gene_id: 55170
strongest_risk_snp: rs4118325
strongest_risk_allele: G
snps: rs4118325
snp_id_current: 4118325
context: Intergenic
pvalue_mlog: 6.221848749616355
ci_95: [2.17-8.33]
platform: Illumina [291,119]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19754311?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genomewide association study of a rapid progression cohort identifies new susceptibility alleles for AIDS (ANRS Genomewide Association Study 03).


dbdate: 2009-09-30
author: Suppiah V
date: 2009-09-13
journal: Nat Genet
study: IL28B is associated with response to chronic hepatitis C interferon-alpha and ribavirin therapy.
trait: Response to hepatitis C treatment
initial_samplesize: 131 European ancestry responders, 162 European ancestry non-responders
replication_samplesize: 261 European ancestry responders, 294 European ancestry non-responders
region: 19q13.2
chrom: 19
reported_genes: IL28A, IL28B
mapped_gene: IFNL4 - MSRB1P1
upstream_gene_id: 101180976
downstream_gene_id: 441849
strongest_risk_snp: rs8099917
strongest_risk_allele: G
snps: rs8099917
snp_id_current: 8099917
context: Intergenic
pvalue_mlog: 8.045757490560675
ci_95: [1.57-2.52]
platform: Illumina [311,159]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19749758?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-09-30
author: Tanaka Y
date: 2009-09-13
journal: Nat Genet
trait: Response to hepatitis C treatment
initial_samplesize: 64 Japanese ancestry responders, 78 Japanese ancestry non-responders
replication_samplesize: 122 Japanese ancestry responders, 50 Japanese ancestry non-responders
region: 19q13.2
chrom: 19
reported_genes: IL28B
mapped_gene: IFNL4 - MSRB1P1
upstream_gene_id: 101180976
downstream_gene_id: 441849
strongest_risk_snp: rs8099917
strongest_risk_allele: G
snps: rs8099917
snp_id_current: 8099917
context: Intergenic
pvalue_mlog: 31.52287874528033
ci_95: [14.6-50.3]
platform: Affymetrix [621,220]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19749757?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association of IL28B with response to pegylated interferon-alpha and ribavirin therapy for chronic hepatitis C.


dbdate: 2009-09-29
author: Harold D
date: 2009-09-06
journal: Nat Genet
trait: Alzheimer's disease
initial_samplesize: 3,941 European ancestry cases, 7,848 European ancestry controls
replication_samplesize: 2,023 European ancestry cases, 2,340 European ancestry controls
region: 8p21.1
chrom: 8
reported_genes: CLU
mapped_gene: CLU
snp_gene_ids: 1191
strongest_risk_snp: rs11136000
snps: rs11136000
snp_id_current: 11136000
context: intron
pvalue_mlog: 9.045757490560675
ci_95: [1.11-1.22]
platform: Illumina [529,205]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19734902?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association study identifies variants at CLU and PICALM associated with Alzheimer's disease.


dbdate: 2009-09-29
author: Lambert JC
date: 2009-09-06
journal: Nat Genet
trait: Alzheimer's disease
initial_samplesize: 2,032 European ancestry cases, 5,328 European ancestry controls
replication_samplesize: 3,978 European ancestry cases, 3,297 European ancestry controls
region: 19q13.32
chrom: 19
reported_genes: APOE
mapped_gene: TOMM40
snp_gene_ids: 10452
strongest_risk_snp: rs2075650
snps: rs2075650
snp_id_current: 2075650
context: intron
pvalue_mlog: 15.69897000433602
platform: Illumina [537,029]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19734903?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association study identifies variants at CLU and CR1 associated with Alzheimer's disease.


dbdate: 2009-09-29
author: Rung J
date: 2009-09-06
journal: Nat Genet
trait: Type 2 diabetes and other traits
initial_samplesize: 679 French ancestry cases, 697 French ancestry controls
replication_samplesize: 5,579 European ancestry cases, 7,096 European ancestry controls
region: 2q36.3
chrom: 2
reported_genes: LOC64673, IRS1
mapped_gene: NYAP2 - MIR5702
upstream_gene_id: 57624
downstream_gene_id: 100847053
strongest_risk_snp: rs2943641
strongest_risk_allele: C
snps: rs2943641
snp_id_current: 2943641
context: Intergenic
pvalue_mlog: 11.04575749056067
ci_95: [1.13-1.25]
platform: Illumina [392,365]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19734900?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia.


dbdate: 2009-09-29
author: van Es MA
date: 2009-09-06
journal: Nat Genet
trait: Amyotrophic lateral sclerosis
initial_samplesize: 2,323 European ancestry cases, 9,013 European ancestry controls
replication_samplesize: 2,532 European ancestry cases, 5,940 European ancestry controls
region: 19p13.11
chrom: 19
reported_genes: UNC13A
mapped_gene: UNC13A
snp_gene_ids: 23025
strongest_risk_snp: rs12608932
snps: rs12608932
snp_id_current: 12608932
context: intron
pvalue_mlog: 13.52287874528034
ci_95: [NR]
platform: Illumina [292,768]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19734901?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association study identifies 19p13.3 (UNC13A) and 9p21.2 as susceptibility loci for sporadic amyotrophic lateral sclerosis.


dbdate: 2012-11-08
author: Need AC
date: 2009-09-04
journal: Hum Mol Genet
study: A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
trait: Cognitive performance
initial_samplesize: Up to 1,295 individuals
region: 2p16.3
chrom: 2
reported_genes: AC007402.3
mapped_gene: LOC730100
snp_gene_ids: 730100
strongest_risk_snp: rs1206397
snps: rs1206397
snp_id_current: 1206397
context: intron
pvalue_mlog: 6.522878745280337
platform: Illumina [475,971]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19734545?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-09-28
author: Paterson AD
date: 2009-09-03
journal: Arterioscler Thromb Vasc Biol
trait: Soluble E-selectin levels
initial_samplesize: 685 European ancestry individuals with type 1 diabetes
replication_samplesize: 477 European ancestry individuals
region: 9q34.2
chrom: 9
reported_genes: ABO
mapped_gene: ABO - SURF6
upstream_gene_id: 28
downstream_gene_id: 6838
strongest_risk_snp: rs579459
strongest_risk_allele: C
snps: rs579459
snp_id_current: 579459
context: Intergenic
pvalue_mlog: 28.99999999999999
platform: Illumina [~841,000]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19729612?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association identifies the ABO blood group as a major locus associated with serum levels of soluble E-selectin.


dbdate: 2009-09-28
author: Tonjes A
date: 2009-09-03
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19729412
trait: Height
initial_samplesize: 929 Sorbian individuals
replication_samplesize: 5,758 European ancestry individuals
region: 12q24.33
chrom: 12
reported_genes: GPR133
mapped_gene: GPR133
snp_gene_ids: 283383
strongest_risk_snp: rs1569019
snps: rs1569019
snp_id_current: 1569019
context: intron
pvalue_mlog: 7.30102999566398
ci_95: [0.61-1.29] cm increase
platform: Affymetrix [390,619]
cnv: N
study:
Genetic variation in GPR133 is associated with height: genome wide association study in the self-contained population of Sorbs.


dbdate: 2009-09-28
author: De Moor MH
date: 2009-09-02
journal: Med Sci Sports Exerc
study: Genome-wide association study of exercise behavior in Dutch and American adults.
trait: Exercise (leisure time)
initial_samplesize: 2,622 European ancestry individuals
region: 10q23.2
chrom: 10
reported_genes: PAPSS2
mapped_gene: PAPSS2
snp_gene_ids: 9060
strongest_risk_snp: rs10887741
strongest_risk_allele: T
snps: rs10887741
snp_id_current: 10887741
context: intron
pvalue_mlog: 5.397940008672037
ci_95: [1.17-1.49]
platform: Affymetrix and Perlegen [~1.6 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19727025?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-09-28
author: McClay JL
date: 2009-09-01
journal: Mol Psychiatry
study: Genome-wide pharmacogenomic analysis of response to treatment with antipsychotics.
trait: Response to antipsychotic treatment
initial_samplesize: 494 European ancestry cases, 244 African American and other ancestry cases
region: 4p15.1
chrom: 4
reported_genes: Intergenic
mapped_gene: RPL31P31 - SEC63P2
upstream_gene_id: 727792
downstream_gene_id: 100420287
strongest_risk_snp: rs17390445
snps: rs17390445
snp_id_current: 17390445
context: Intergenic
pvalue_mlog: 7
ci_95: [NR] % of variance explained
platform: Affymetrix & Perlegen [492,900]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19721433?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-09-09
author: Hancock DB
date: 2009-08-28
journal: PLoS Genet
trait: Asthma (childhood onset)
initial_samplesize: 492 Mexican ancestry trios
replication_samplesize: 177 Mexican ancestry trios
region: 9q21.31
chrom: 9
reported_genes: TLE4, CHCHD9
mapped_gene: CHCHD2P9 - TLE4
upstream_gene_id: 645345
downstream_gene_id: 7091
strongest_risk_snp: rs2378383
snps: rs2378383
snp_id_current: 2378383
context: Intergenic
pvalue_mlog: 6.154901959985743
ci_95: [1.32-2.04]
platform: Illumina [520,767]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19714205?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association study implicates chromosome 9q21.31 as a susceptibility locus for asthma in mexican children.


dbdate: 2009-09-24
author: Liu YZ
date: 2009-08-28
journal: PLoS One
trait: Obesity and osteoporosis
initial_samplesize: 499 European ancestry males, 501 European ancestry females
replication_samplesize: 1,370 European ancestry males and 1,985 European ancestry females from 975 families
region: 11p15.1
chrom: 11
reported_genes: SOX6
mapped_gene: SOX6
snp_gene_ids: 55553
strongest_risk_snp: rs297325
strongest_risk_allele: C
snps: rs297325
snp_id_current: 297325
context: intron
pvalue_mlog: 6.397940008672037
platform: Affymetrix [379,319]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19714249?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Powerful bivariate genome-wide association analyses suggest the SOX6 gene influencing both obesity and osteoporosis phenotypes in males.


dbdate: 2009-09-09
author: Shuldiner AR
date: 2009-08-26
journal: JAMA
link: http://www.ncbi.nlm.nih.gov/pubmed/19706858
trait: Response to clopidogrel therapy
initial_samplesize: 429 Amish individuals
replication_samplesize: 140 European ancestry individuals, 83 African American individuals, 4 Other ancestry individuals
region: 10q23.33
chrom: 10
reported_genes: CYP2C18, CYP2C19, CYP2C9, CYP2C8
mapped_gene: HELLS - CTBP2P2
upstream_gene_id: 3070
downstream_gene_id: 100130970
strongest_risk_snp: rs12777823
snps: rs12777823
snp_id_current: 12777823
context: Intergenic
pvalue_mlog: 12.69897000433602
platform: Affymetrix [400,230]
cnv: N
study:
Association of cytochrome P450 2C19 genotype with the antiplatelet effect and clinical efficacy of clopidogrel therapy.


dbdate: 2009-09-09
author: Cui R
date: 2009-08-18
journal: Gastroenterology
link: http://www.ncbi.nlm.nih.gov/pubmed/19698717
trait: Esophageal cancer
initial_samplesize: 182 Japanese ancestry cases, 927 Japanese ancestry controls
replication_samplesize: 782 Japanese ancestry cases, 1,898 Japanese ancestry controls
region: 12q24.12
chrom: 12
reported_genes: BRAP, ALDH2
mapped_gene: ALDH2
snp_gene_ids: 217
strongest_risk_snp: rs671
strongest_risk_allele: A
snps: rs671
snp_id_current: 671
context: missense
pvalue_mlog: 23.52287874528033
ci_95: [1.58-1.76]
platform: Illumina [359,195]
cnv: N
study:
Functional variants in ADH1B and ALDH2 coupled with alcohol and smoking synergistically enhance esophageal cancer risk.


dbdate: 2009-09-04
author: Papaemmanuil E
date: 2009-08-16
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19684604
trait: Acute lymphoblastic leukemia (childhood)
initial_samplesize: 907 European ancestry cases, 2,398 European ancestry controls
region: 7p12.2
chrom: 7
reported_genes: IKZF1
mapped_gene: IKZF1
snp_gene_ids: 10320
strongest_risk_snp: rs4132601
strongest_risk_allele: C
snps: rs4132601
snp_id_current: 4132601
context: UTR-3
pvalue_mlog: 19
ci_95: [1.58-1.81]
platform: Illumina [291,473]
cnv: N
study:
Loci on 7p12.2, 10q21.2 and 14q11.2 are associated with risk of childhood acute lymphoblastic leukemia.


dbdate: 2009-09-11
author: Trevino LR
date: 2009-08-16
journal: Nat Genet
study: Germline genomic variants associated with childhood acute lymphoblastic leukemia.
trait: Acute lymphoblastic leukemia (childhood)
initial_samplesize: 317 European descent cases, 17,958 European descent controls
region: 10q21.2
chrom: 10
reported_genes: ARID5B
mapped_gene: ARID5B
snp_gene_ids: 84159
strongest_risk_snp: rs10821936
strongest_risk_allele: C
snps: rs10821936
snp_id_current: 10821936
context: intron
pvalue_mlog: 15
ci_95: [1.60-2.20]
platform: Affymetrix [307,944]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19684603?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-09-04
author: Alkelai A
date: 2009-08-13
journal: Psychopharmacology (Berl)
trait: Response to antipsychotic treatment
region: 2q24.3
chrom: 2
reported_genes: FIGN
mapped_gene: RPL7P61 - FIGN
upstream_gene_id: 101929589
downstream_gene_id: 55137
strongest_risk_snp: rs12476047
strongest_risk_allele: C
snps: rs12476047
snp_id_current: 12476047
context: Intergenic
pvalue_mlog: 5.522878745280337
ci_95: [1.97-5.25]
platform: Affymetrix & Perlegen [495,172]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19680635?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association study of antipsychotic-induced parkinsonism severity among schizophrenia patients.

initial_samplesize:
140 European ancestry cases, 57 African American cases, 2 Other ancestry cases, 117 European ancestry controls, 72 African American controls, 9 Other ancestry controls


dbdate: 2009-09-09
author: Potkin SG
date: 2009-08-07
journal: PLoS One
trait: Hippocampal atrophy
region: 1q21.3
chrom: 1
reported_genes: S100A5
mapped_gene: S100A7 - S100A6
upstream_gene_id: 6278
downstream_gene_id: 6277
strongest_risk_snp: rs4845552
snps: rs4845552
snp_id_current: 4845552
context: Intergenic
pvalue_mlog: 5.221848749616356
platform: Illumina [516,645]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19668339?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.

initial_samplesize:
162 European ancestry cases, 7 African American cases, 1 Asian ancestry cases, 2 Other ancestry cases, 192 European ancestry controls, 14 African American controls, 3 Asian ancestry controls


dbdate: 2009-09-04
author: Tse KP
date: 2009-08-05
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19664746
trait: Nasopharyngeal carcinoma
initial_samplesize: 277 Han Chinese ancestry cases, 285 Han Chinese ancestry controls
replication_samplesize: 635 Han Chinese ancestry cases, 1,640 Han Chinese ancestry controls
region: 6p22.1
chrom: 6
reported_genes: HLA-A
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs2517713
strongest_risk_allele: A
snps: rs2517713
snp_id_current: 2517713
pvalue_mlog: 19.39794000867203
ci_95: [1.65-2.15]
platform: Illumina [480,365]
cnv: N
study:
Genome-wide association study reveals multiple nasopharyngeal carcinoma-associated loci within the HLA region at chromosome 6p21.3.


dbdate: 2009-09-14
author: Broderick P
date: 2009-08-04
journal: Cancer Res
link: http://www.ncbi.nlm.nih.gov/pubmed/19654303
trait: Lung cancer
initial_samplesize: 1,952 European ancestry cases, 1,438 European ancestry controls
region: 15q25.1
chrom: 15
reported_genes: CHRNA3
mapped_gene: HYKK
snp_gene_ids: 123688
strongest_risk_snp: rs8034191
snps: rs8034191
snp_id_current: 8034191
context: intron
pvalue_mlog: 25.52287874528034
ci_95: [1.23-1.35]
platform: Illumina [511,919]
cnv: N
study:
Deciphering the impact of common genetic variation on lung cancer risk: a genome-wide association study.

replication_samplesize:
2,465 European ancestry cases, 3,005 European ancestry controls, 3,143 individuals, 3,762 individuals


dbdate: 2009-09-04
author: Chambers JC
date: 2009-08-03
journal: Diabetes
link: http://www.ncbi.nlm.nih.gov/pubmed/19651812
trait: Fasting plasma glucose
initial_samplesize: 698 Asian Indian ancestry cases, 6,776 Asian Indian ancestry controls
replication_samplesize: 4,462 European ancestry controls
region: 11q14.3
chrom: 11
reported_genes: MTNR1B
mapped_gene: RPS3AP42 - MTNR1B
upstream_gene_id: 100271597
downstream_gene_id: 4544
strongest_risk_snp: rs2166706
strongest_risk_allele: G
snps: rs2166706
snp_id_current: 2166706
context: Intergenic
pvalue_mlog: 8.698970004336019
ci_95: (0.04-0.09) mmol/L increase
platform: Illumina [up to 544,390]
cnv: N
study:
Common genetic variation near melatonin receptor MTNR1B contributes to raised plasma glucose and increased risk of type 2 diabetes among Indian Asians and European Caucasians.


dbdate: 2009-09-04
author: Grant SF
date: 2009-08-03
journal: J Pediatr
link: http://www.ncbi.nlm.nih.gov/pubmed/19656524
trait: Orofacial clefts
initial_samplesize: 111 European ancestry cases, 5,951 European ancestry controls
region: 8q24.21
chrom: 8
reported_genes: Intergenic
mapped_gene: LINC01263 - LINC00977
upstream_gene_id: 101927774
downstream_gene_id: 728724
strongest_risk_snp: rs987525
snps: rs987525
snp_id_current: 987525
context: Intergenic
pvalue_mlog: 7.045757490560674
ci_95: [1.59-2.76]
platform: Illumina [495,858]
cnv: N
study:
A genome-wide association study identifies a locus for nonsyndromic cleft lip with or without cleft palate on 8q24.


dbdate: 2009-09-04
author: Amundadottir L
date: 2009-08-02
journal: Nat Genet
trait: Pancreatic cancer
initial_samplesize: 1,771 European ancestry cases, 1,805 European ancestry controls
replication_samplesize: 2,120 European ancestry cases, 2,127 European ancestry controls
region: 9q34.2
chrom: 9
reported_genes: ABO
mapped_gene: ABO
snp_gene_ids: 28
strongest_risk_snp: rs505922
strongest_risk_allele: C
snps: rs505922
snp_id_current: 505922
context: intron
pvalue_mlog: 7.30102999566398
ci_95: [1.12-1.28]
platform: Illumina [558,542]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19648918?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association study identifies variants in the ABO locus associated with susceptibility to pancreatic cancer.


dbdate: 2009-09-04
author: Song H
date: 2009-08-02
journal: Nat Genet
study: A genome-wide association study identifies a new ovarian cancer susceptibility locus on 9p22.2.
trait: Ovarian cancer
initial_samplesize: 1,817 European ancestry cases, 2,353 European ancestry controls
replication_samplesize: 6,944 European ancestry cases, 9,477 European ancestry controls
region: 9p22.2
chrom: 9
reported_genes: BNC2, LOC648570, CNTLN
mapped_gene: LSM1P1 - RPL31P42
upstream_gene_id: 100820732
downstream_gene_id: 100271197
strongest_risk_snp: rs3814113
strongest_risk_allele: T
snps: rs3814113
snp_id_current: 3814113
context: Intergenic
pvalue_mlog: 18.30102999566398
ci_95: [1.16-1.27]
platform: Illumina [up to ~2,000,000] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19648919?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-08-21
author: Wu X
date: 2009-08-02
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19648920
trait: Bladder cancer
initial_samplesize: 969 European ancestry cases, 957 European ancestry controls
replication_samplesize: 5,698 European ancestry cases, 38,633 European ancestry controls
region: 8q24.3
chrom: 8
reported_genes: PSCA
mapped_gene: PSCA
snp_gene_ids: 8000
strongest_risk_snp: rs2294008
strongest_risk_allele: T
snps: rs2294008
snp_id_current: 2294008
context: intron
pvalue_mlog: 9.698970004336017
ci_95: [1.10-1.20]
platform: Illumina [556,429]
cnv: N
study:
Genetic variation in the prostate stem cell antigen gene PSCA confers susceptibility to urinary bladder cancer.


dbdate: 2009-12-29
author: Cheng YC
date: 2009-08-01
journal: Circ Cardiovasc Genet
trait: Matrix metalloproteinase levels
initial_samplesize: 778 Old Order Amish individuals
region: 11q22.2
chrom: 11
reported_genes: MMP
mapped_gene: WTAPP1
snp_gene_ids: 100288077
strongest_risk_snp: rs495366
strongest_risk_allele: A
snps: rs495366
snp_id_current: 495366
context: intron
pvalue_mlog: 33.22184874961636
ci_95: [NR] unit decrease in ln(MMP-1)
platform: Affymetrix [338,079]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20031604?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=2

study:
Genome-wide association scan identifies variants near Matrix Metalloproteinase (MMP) genes on chromosome 11q21-22 strongly associated with serum MMP-1 levels.


dbdate: 2009-12-29
author: Marroni F
date: 2009-08-01
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20031603
trait: QT interval
initial_samplesize: 2,325 European ancestry individuals
region: 1q23.3
chrom: 1
reported_genes: NOS1AP
mapped_gene: OLFML2B - NOS1AP
upstream_gene_id: 25903
downstream_gene_id: 9722
strongest_risk_snp: rs2880058
strongest_risk_allele: G
snps: rs2880058
snp_id_current: 2880058
context: Intergenic
pvalue_mlog: 9.698970004336017
ci_95: [0.13-0.25] unit increase
platform: Illumina [~318,327]
cnv: N
study:
A genome-wide association scan of RR and QT interval duration in 3 European genetically isolated populations: the EUROSPAN project.


dbdate: 2009-08-21
author: Skibola CF
date: 2009-07-20
journal: Nat Genet
study: Genetic variants at 6p21.33 are associated with susceptibility to follicular lymphoma.
trait: Follicular lymphoma
initial_samplesize: 189 European ancestry cases, 592 European controls
replication_samplesize: 456 European ancestry cases, 2,785 European ancestry controls
region: 6p21.33
chrom: 6
reported_genes: STG, PSORS1
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs6457327
strongest_risk_allele: C
snps: rs6457327
snp_id_current: 6457327
pvalue_mlog: 10.30102999566398
ci_95: [1.43-2.00]
platform: Illumina [~500,000] (pooled)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19620980?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-08-12
author: Adeyemo A
date: 2009-07-17
journal: PLoS Genet
study: A genome-wide association study of hypertension and blood pressure in African Americans.
trait: Hypertension
initial_samplesize: 509 African American cases, 508 African American controls
replication_samplesize: 366 West African ancestry cases, 614 West African ancestry controls
region: 4q23
chrom: 4
reported_genes: ADH7
mapped_gene: LOC102723576
snp_gene_ids: 102723576
strongest_risk_snp: rs991316
strongest_risk_allele: T
snps: rs991316
snp_id_current: 991316
context: intron
pvalue_mlog: 5.301029995663981
ci_95: [NR]
platform: Affymetrix [808,465]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19609347?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-08-04
author: Benjamin EJ
date: 2009-07-13
journal: Nat Genet
study: Variants in ZFHX3 are associated with atrial fibrillation in individuals of European ancestry.
trait: Atrial fibrillation
initial_samplesize: 3,413 cases, 37,105 referents
replication_samplesize: 2,145 cases, 4,073 controls
region: 4q25
chrom: 4
reported_genes: PITX2
mapped_gene: PITX2 - MIR297
upstream_gene_id: 5308
downstream_gene_id: 100126354
strongest_risk_snp: rs17042171
strongest_risk_allele: A
snps: rs17042171
snp_id_current: 17042171
context: Intergenic
pvalue_mlog: 62.39794000867203
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19597492?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-07-30
author: Gudbjartsson DF
date: 2009-07-13
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19597491
study: A sequence variant in ZFHX3 on 16q22 associates with atrial fibrillation and ischemic stroke.
trait: Atrial fibrillation
initial_samplesize: 2,385 European ancestry cases, 33,752 European ancestry controls
region: 16q22.3
chrom: 16
reported_genes: ZFHX3
mapped_gene: ZFHX3
snp_gene_ids: 463
strongest_risk_snp: rs7193343
strongest_risk_allele: T
snps: rs7193343
snp_id_current: 7193343
context: intron
pvalue_mlog: 10
ci_95: [1.14-1.29]
platform: Illumina [303,136]
cnv: N
replication_samplesize:
up to 2,427 European ancestry cases, 3,379 European ancestry controls, 286 Han Chinese ancestry cases, 2,763 Han Chinese ancestry controls


dbdate: 2009-07-24
author: Nolte IM
date: 2009-07-09
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/19587794
trait: QT interval
initial_samplesize: 3,558 European ancestry individuals
replication_samplesize: 29,527 European ancestry individuals
region: 1q23.3
chrom: 1
reported_genes: OLFML2B, NOS1AP
mapped_gene: OLFML2B - NOS1AP
upstream_gene_id: 25903
downstream_gene_id: 9722
strongest_risk_snp: rs12143842
strongest_risk_allele: T
snps: rs12143842
snp_id_current: 12143842
context: Intergenic
pvalue_mlog: 83
ci_95: [NR] unit increase
platform: Affymetrix & Illumina [~2,399,142] (imputed)
cnv: N
study:
Common genetic variation near the phospholamban gene is associated with cardiac repolarisation: meta-analysis of three genome-wide association studies.


dbdate: 2009-08-07
author: Vasan RS
date: 2009-07-08
journal: JAMA
trait: Aortic root size
initial_samplesize: 12,612 European ancestry individuals
replication_samplesize: 4,094 European ancestry individuals
region: 17p13.3
chrom: 17
reported_genes: SMG6, SRR, TSR1, SGSM2
mapped_gene: SMG6
snp_gene_ids: 23293
strongest_risk_snp: rs10852932
strongest_risk_allele: T
snps: rs10852932
snp_id_current: 10852932
context: intron
pvalue_mlog: 10.69897000433602
ci_95: [0.02-0.04] cm increase
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19584346?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genetic variants associated with cardiac structure and function: a meta-analysis and replication of genome-wide association data.


dbdate: 2009-07-16
author: Bishop DT
date: 2009-07-05
journal: Nat Genet
study: Genome-wide association study identifies three loci associated with melanoma risk.
trait: Melanoma
initial_samplesize: 1,539 European ancestry cases, 3,917 European ancestry controls
replication_samplesize: 2,312 European ancestry cases, 1,867 European ancestry controls
region: 9p21.3
chrom: 9
reported_genes: CDKN2A
mapped_gene: MTAP
snp_gene_ids: 4507
strongest_risk_snp: rs7023329
strongest_risk_allele: A
snps: rs7023329
snp_id_current: 7023329
context: intron
pvalue_mlog: 6.397940008672037
ci_95: [1.10-1.25]
platform: Illumina [~317,000]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19578364?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-07-13
author: Falchi M
date: 2009-07-05
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19578365
trait: Cutaneous nevi
initial_samplesize: 1,524 European ancestry twins
region: 9p21.3
chrom: 9
reported_genes: MTAP
mapped_gene: KHSRPP1 - MTAP
upstream_gene_id: 402359
downstream_gene_id: 4507
strongest_risk_snp: rs4636294
strongest_risk_allele: A
snps: rs4636294
snp_id_current: 4636294
context: Intergenic
pvalue_mlog: 14.52287874528034
ci_95: [0.13-0.27] increase in log nevus count
platform: Illumina [297,108]
cnv: N
study:
Genome-wide association study identifies variants at 9p21 and 22q13 associated with development of cutaneous nevi.

replication_samplesize:
4,107 European ancestry individuals, 3,131 European ancestry cases, 4,276 European ancestry controls


dbdate: 2009-07-12
author: Shete S
date: 2009-07-05
journal: Nat Genet
study: Genome-wide association study identifies five susceptibility loci for glioma.
trait: Glioma
initial_samplesize: 1,878 European ancestry cases, 3,670 European ancestry controls
replication_samplesize: 2,545 European ancestry cases, 2,953 European ancestry controls
region: 5p15.33
chrom: 5
reported_genes: TERT
mapped_gene: TERT
snp_gene_ids: 7015
strongest_risk_snp: rs2736100
strongest_risk_allele: G
snps: rs2736100
snp_id_current: 2736100
context: intron
pvalue_mlog: 16.69897000433602
ci_95: [1.19-1.37]
platform: Illumina [454,576]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19578367?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-07-12
author: Wrensch M
date: 2009-07-05
journal: Nat Genet
study: Variants in the CDKN2B and RTEL1 regions are associated with high-grade glioma susceptibility.
trait: Glioma (high-grade)
initial_samplesize: 692 European ancestry cases, 3,992 European ancestry controls
replication_samplesize: 176 cases, 174 controls
region: 9p21.3
chrom: 9
reported_genes: Intergenic
mapped_gene: CDKN2B-AS1
snp_gene_ids: 100048912
strongest_risk_snp: rs1412829
strongest_risk_allele: C
snps: rs1412829
snp_id_current: 1412829
context: intron
pvalue_mlog: 9.698970004336017
ci_95: [1.27-1.58]
platform: Illumina [326,506]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19578366?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-07-24
author: Estrada K
date: 2009-07-01
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19570815
trait: Height
initial_samplesize: 10,074 European ancestry individuals
replication_samplesize: 6,912 European ancestry individuals
region: 2q37.1
chrom: 2
reported_genes: DIS3L2, ALPP, NPPC
mapped_gene: DIS3L2
snp_gene_ids: 129563
strongest_risk_snp: rs6717918
strongest_risk_allele: T
snps: rs6717918
snp_id_current: 6717918
context: intron
pvalue_mlog: 8.522878745280337
ci_95: [0.20-0.68] cm increase
platform: Affymetrix, Illumina & Perlegen [2,228,850] (imputed)
cnv: N
study:
A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation.


dbdate: 2009-07-10
author: Shi J
date: 2009-07-01
journal: Nature
link: http://www.ncbi.nlm.nih.gov/pubmed/19571809
study: Common variants on chromosome 6p22.1 are associated with schizophrenia.
trait: Schizophrenia
replication_samplesize: 5,327 European ancestry cases, 16,424 European ancestry controls
region: 6p22.1
chrom: 6
reported_genes: SLC17A1, SLC17A3, BTN3A2, BTN2A2, BTN3A1, HIST1H2AG, HIST1H2BJ, PRSS16, POM121L2, ZNF184
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs13194053
strongest_risk_allele: T
snps: rs13194053
snp_id_current: 13194053
pvalue_mlog: 8
ci_95: [NR]
platform: Affymetrix [up to 843,798]
cnv: N
initial_samplesize:
2,681 European ancestry cases, 2,653 European ancestry controls, 1,286 African American cases, 973 African American controls


dbdate: 2009-07-01
author: Heard-Costa NL
date: 2009-06-26
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19557197
trait: Waist circumference
initial_samplesize: 31,373 European ancestry individuals
replication_samplesize: 38,641 individuals
region: 14q31.1
chrom: 14
reported_genes: NRXN3
mapped_gene: NRXN3
snp_gene_ids: 9369
strongest_risk_snp: rs10146997
strongest_risk_allele: G
snps: rs10146997
snp_id_current: 10146997
context: intron
pvalue_mlog: 7.30102999566398
ci_95: [NR] cm increase
platform: Affymetrix & Illumina [up to 512,349]
cnv: N
study:
NRXN3 is a novel locus for waist circumference: a genome-wide association study from the CHARGE Consortium.


dbdate: 2009-07-01
author: Lindgren CM
date: 2009-06-26
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19557161
trait: Adiposity
initial_samplesize: 38,580 European ancestry individuals
replication_samplesize: Up to 102,064 European ancestry individuals
region: 6p12.3
chrom: 6
reported_genes: TFAP2B
mapped_gene: TFAP2B
snp_gene_ids: 7021
strongest_risk_snp: rs987237
strongest_risk_allele: G
snps: rs987237
snp_id_current: 987237
context: intron
pvalue_mlog: 10.69897000433602
ci_95: [0.03-0.05] z-score unit increase
platform: Affymetrix & Illumina [2,573,738] (imputed)
cnv: N
study:
Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution.


dbdate: 2009-06-30
author: Bahlo
date: 2009-06-14
journal: Nat Genet
trait: Multiple sclerosis
initial_samplesize: 1,618 European ancestry cases, 3,413 European ancestry controls
replication_samplesize: 2,256 European ancestry cases, 2,310 European ancestry controls
region: 12q14.1
chrom: 12
reported_genes: METTL1, CYP27B1
mapped_gene: CYP27B1;METTL1
snp_gene_ids: 1594;4234
strongest_risk_snp: rs703842
strongest_risk_allele: A
snps: rs703842
snp_id_current: 703842
context: nearGene-5;UTR-3
pvalue_mlog: 10.30102999566398
ci_95: [NR]
platform: Illumina [302,098]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19525955?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20.


dbdate: 2009-06-29
author: De Jager PL
date: 2009-06-14
journal: Nat Genet
trait: Multiple sclerosis
initial_samplesize: 2,624 European ancestry cases, 7,220 European ancestry controls
replication_samplesize: 2,215 European ancestry cases, 2,116 European ancestry controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DRB1
mapped_gene: HLA-DRA
snp_gene_ids: 3122
strongest_risk_snp: rs3135388
strongest_risk_allele: A
snps: rs3135388
snp_id_current: 3135388
context: intron
pvalue_mlog: 224.397940008672
ci_95: [2.46-3.07]
platform: Affymetrix & Illumina [~2.56 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19525953?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Meta-analysis of genome scans and replication identify CD6, IRF8 and TNFRSF1A as new multiple sclerosis susceptibility loci.


dbdate: 2009-06-17
author: Gregersen PK
date: 2009-06-07
journal: Nat Genet
trait: Rheumatoid arthritis
initial_samplesize: 2,418 European ancestry cases, 4,504 European ancestry controls
replication_samplesize: 2,604 cases, 2,882 controls
region: 2p16.1
chrom: 2
reported_genes: REL
mapped_gene: REL
snp_gene_ids: 5966
strongest_risk_snp: rs13017599
strongest_risk_allele: A
snps: rs13017599
snp_id_current: 13017599
context: intron
pvalue_mlog: 11.69897000433602
ci_95: [1.15-1.28]
platform: Illumina [278,502]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19503088?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
REL, encoding a member of the NF-kappaB family of transcription factors, is a newly defined risk locus for rheumatoid arthritis.


dbdate: 2009-06-22
author: Kolz M
date: 2009-06-05
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19503597
trait: Uric acid levels
initial_samplesize: 12,328 European ancestry males, 15,813 European ancestry females
region: 1q21.1
chrom: 1
reported_genes: PDZK1
mapped_gene: PDZK1
snp_gene_ids: 5174
strongest_risk_snp: rs12129861
strongest_risk_allele: A
snps: rs12129861
snp_id_current: 12129861
context: nearGene-5
pvalue_mlog: 8.522878745280337
ci_95: [0.042-0.083] mg/dl decrease
platform: Affymetrix and Illumina [2,493,963] (imputed)
cnv: N
study:
Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations.


dbdate: 2009-06-16
author: Smith EN
date: 2009-06-02
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/19488044
trait: Bipolar disorder
region: 19q13.11
chrom: 19
reported_genes: DPY19L3
mapped_gene: DPY19L3
snp_gene_ids: 147991
strongest_risk_snp: rs2111504
strongest_risk_allele: T
snps: rs2111504
snp_id_current: 2111504
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [NR]
platform: Affymetrix [702,044]
cnv: N
study:
Genome-wide association study of bipolar disorder in European American and African American individuals.

initial_samplesize:
1,001 European ancestry cases, 1,033 European ancestry controls, 345 African American cases, 670 African American controls

replication_samplesize:
1,550 European ancestry individuals from 250 families, 1,263 European ancestry cases, 431 European ancestry controls


dbdate: 2009-06-15
author: Daly AK
date: 2009-05-31
journal: Nat Genet
study: HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin.
trait: Drug-induced liver injury (flucloxacillin)
initial_samplesize: 58 European ancestry cases, 282 European ancestry controls
region: 6p21.33
chrom: 6
reported_genes: HCP5, HLA-B
mapped_gene: HCP5
snp_gene_ids: 10866
strongest_risk_snp: rs2395029
snps: rs2395029
snp_id_current: 2395029
context: ncRNA
pvalue_mlog: 32.04575749056067
ci_95: [19.4-105]
platform: Illumina [866,399]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19483685?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-06-14
author: Rapley EA
date: 2009-05-31
journal: Nat Genet
study: A genome-wide association study of testicular germ cell tumor.
trait: Testicular germ cell tumor
initial_samplesize: 730 cases, 1,435 controls
replication_samplesize: 571 cases, 1,806 controls
region: 1q24.1
chrom: 1
reported_genes: Intergenic
mapped_gene: UCK2
snp_gene_ids: 7371
strongest_risk_snp: rs4657482
strongest_risk_allele: A
snps: rs4657482
snp_id_current: 4657482
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [0.99-1.31]
platform: Illumina [307,666]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19483681?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-06-16
author: Aston KI
date: 2009-05-28
journal: J Androl
link: http://www.ncbi.nlm.nih.gov/pubmed/19478329
trait: Male infertility
region: 3q11.2
chrom: 3
reported_genes: ARL6
mapped_gene: MTHFD2P1 - HNRNPKP4
upstream_gene_id: 100287639
downstream_gene_id: 644063
strongest_risk_snp: rs9814870
snps: rs9814870
snp_id_current: 9814870
context: Intergenic
pvalue_mlog: 6.154901959985743
platform: Illumina [314,776]
cnv: N
study:
Genome-wide study of single-nucleotide polymorphisms associated with azoospermia and severe oligozoospermia.

initial_samplesize:
52 European ancestry oligozoospermic cases, 40 European ancestry non-obstructive azoospermic cases, 80 European ancestry controls


dbdate: 2009-06-10
author: Ma D
date: 2009-05-28
journal: Ann Hum Genet
study: A genome-wide association study of autism reveals a common novel risk locus at 5p14.1.
trait: Autism
initial_samplesize: 1,390 European ancestry individuals from 438 families
replication_samplesize: 2,390 European ancestry individuals from 457 families
region: 5p14.1
chrom: 5
reported_genes: Intergenic
mapped_gene: CDH10 - MSNP1
upstream_gene_id: 1008
downstream_gene_id: 4479
strongest_risk_snp: rs10038113
strongest_risk_allele: T
snps: rs10038113
snp_id_current: 10038113
context: Intergenic
pvalue_mlog: 5.522878745280337
ci_95: [1.11-1.43]
platform: Illumina [775,311]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19456320?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-06-21
author: Hirschfield GM
date: 2009-05-20
journal: N Engl J Med
study: Primary biliary cirrhosis associated with HLA, IL12A, and IL12RB2 variants.
trait: Primary biliary cirrhosis
initial_samplesize: 505 European ancestry cases, 1,507 European ancestry controls
replication_samplesize: 526 Eurpopean ancestry cases, 1,206 European ancestry controls
region: 3q25.33
chrom: 3
reported_genes: IL12A
mapped_gene: IL12A-AS1
snp_gene_ids: 101928376
strongest_risk_snp: rs6441286
strongest_risk_allele: G
snps: rs6441286
snp_id_current: 6441286
context: intron
pvalue_mlog: 13.69897000433602
ci_95: [1.38-1.72]
platform: Illumina [305,724]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19458352?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-06-14
author: Arnett DK
date: 2009-05-19
journal: BMC Med Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19454037
trait: Left ventricular mass
initial_samplesize: 101 European ancestry cases, 101 European ancestry controls
replication_samplesize: 704 European ancestry individuals, 1,467 African American individuals
region: 5p13.2
chrom: 5
reported_genes: RAI14
mapped_gene: C1QTNF3 - RAI14
upstream_gene_id: 114899
downstream_gene_id: 26064
strongest_risk_snp: rs409045
snps: rs409045
snp_id_current: 409045
context: Intergenic
pvalue_mlog: 6.096910013008056
ci_95: [NR] (LVMI)
platform: Affymetrix [96,258]
cnv: N
study:
Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study.


dbdate: 2009-06-04
author: Landers JE
date: 2009-05-18
journal: Proc Natl Acad Sci U S A
trait: Amyotrophic lateral sclerosis
initial_samplesize: 1,821 cases, 2,258 controls
replication_samplesize: 538 cases, 556 controls
region: 18q12.1
chrom: 18
reported_genes: B4GALT6
mapped_gene: B4GALT6
snp_gene_ids: 9331
strongest_risk_snp: rs10438933
strongest_risk_allele: G
snps: rs10438933
snp_id_current: 10438933
context: intron
pvalue_mlog: 5.999999999999999
ci_95: [NR]
platform: Illumina [288,357]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19451621?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Reduced expression of the Kinesin-Associated Protein 3 (KIFAP3) gene increases survival in sporadic amyotrophic lateral sclerosis.


dbdate: 2009-06-04
author: He C
date: 2009-05-17
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19448621
trait: Menarche and menopause (age at onset)
initial_samplesize: 17,438 European ancestry women
region: 6q16.3
chrom: 6
reported_genes: LIN28B
mapped_gene: LIN28B
snp_gene_ids: 389421
strongest_risk_snp: rs314277
strongest_risk_allele: A
snps: rs314277
snp_id_current: 314277
context: intron
pvalue_mlog: 12.52287874528034
ci_95: [0.12-0.20] years older
platform: Illumina [317,759]
cnv: N
study:
Genome-wide association studies identify loci associated with age at menarche and age at natural menopause.


dbdate: 2009-06-01
author: Ong KK
date: 2009-05-17
journal: Nat Genet
study: Genetic variation in LIN28B is associated with the timing of puberty.
trait: Menarche (age at onset)
initial_samplesize: 4,714 European ancestry women
replication_samplesize: 16,373 women
region: 6q16.3
chrom: 6
reported_genes: LIN28B
mapped_gene: LIN28B
snp_gene_ids: 389421
strongest_risk_snp: rs314276
strongest_risk_allele: C
snps: rs314276
snp_id_current: 314276
context: intron
pvalue_mlog: 15.39794000867204
ci_95: [0.11-0.17] years younger
platform: Affymetrix [up to 390,631]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19448623?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-05-28
author: Perry JR
date: 2009-05-17
journal: Nat Genet
study: Meta-analysis of genome-wide association data identifies two loci influencing age at menarche.
trait: Menarche (age at onset)
initial_samplesize: 17,510 European ancestry women
region: 9q31.2
chrom: 9
reported_genes: TMEM38B, SLC44A1, FKTN, FSD1L, TAL2, ZNF462
mapped_gene: SLC25A6P5 - MIR8081
upstream_gene_id: 100129319
downstream_gene_id: 102465995
strongest_risk_snp: rs2090409
strongest_risk_allele: A
snps: rs2090409
snp_id_current: 2090409
context: Intergenic
pvalue_mlog: 8.698970004336019
ci_95: [0.06-0.14] years younger
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19448620?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-05-28
author: Stolk L
date: 2009-05-15
journal: Nat Genet
study: Loci at chromosomes 13, 19 and 20 influence age at natural menopause.
trait: Menopause (age at onset)
initial_samplesize: 2,979 European ancestry women
replication_samplesize: 2,560 European ancestry women
region: 19q13.42
chrom: 19
reported_genes: BRSK1, TMEM224, SUV420H2
mapped_gene: BRSK1
snp_gene_ids: 84446
strongest_risk_snp: rs1172822
strongest_risk_allele: T
snps: rs1172822
snp_id_current: 1172822
context: intron
pvalue_mlog: 10.22184874961635
ci_95: [0.27-0.51] years younger
platform: Illumina [315,418]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19448619?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-06-01
author: Barrett JC
date: 2009-05-10
journal: Nat Genet
trait: Type 1 diabetes
initial_samplesize: 7,514 cases, 9,045 controls
replication_samplesize: 4,267 cases, 4,670 controls, 4,342 trios from 2,319 families
region: 1p13.2
chrom: 1
reported_genes: PTPN22
mapped_gene: PTPN22;LOC101928822
snp_gene_ids: 26191;101928822
strongest_risk_snp: rs2476601
snps: rs2476601
snp_id_current: 2476601
context: missense;intron
pvalue_mlog: 84.04575749056066
platform: Affymetrix & Illumina [841,622] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19430480?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association study and meta-analysis find that over 40 loci affect risk of type 1 diabetes.


dbdate: 2009-05-27
author: Kottgen A
date: 2009-05-10
journal: Nat Genet
study: Multiple loci associated with indices of renal function and chronic kidney disease.
trait: Renal function and chronic kidney disease
initial_samplesize: 2,388 European ancestry cases, 17,489 European ancestry controls
replication_samplesize: 1,932 cases, 19,534 controls
region: 16p12.3
chrom: 16
reported_genes: UMOD
mapped_gene: UMOD - PDILT
upstream_gene_id: 7369
downstream_gene_id: 204474
strongest_risk_snp: rs12917707
strongest_risk_allele: G
snps: rs12917707
snp_id_current: 12917707
context: Intergenic
pvalue_mlog: 11.69897000433602
ci_95: [1.18-1.33]
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19430482?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-05-19
author: Levy D
date: 2009-05-10
journal: Nat Genet
study: Genome-wide association study of blood pressure and hypertension.
trait: Diastolic blood pressure
initial_samplesize: 29,136 European ancestry individuals
replication_samplesize: 34,433 European ancestry individuals
region: 3p22.1
chrom: 3
reported_genes: ULK4
mapped_gene: ULK4
snp_gene_ids: 54986
strongest_risk_snp: rs9815354
strongest_risk_allele: A
snps: rs9815354
snp_id_current: 9815354
context: intron
pvalue_mlog: 8.522878745280337
ci_95: [0.33-0.65] mm Hg increase
platform: Affymetrix & Illumina [2,533,153](imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19430479?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-05-19
author: Newton-Cheh C
date: 2009-05-10
journal: Nat Genet
study: Genome-wide association study identifies eight loci associated with blood pressure.
trait: Diastolic blood pressure
initial_samplesize: 34,433 European ancestry individuals
replication_samplesize: Up to 100,347 European ancestry individuals, up to 12,889 Indian Asian ancestry individuals
region: 3q26.2
chrom: 3
reported_genes: MDS1
mapped_gene: MECOM
snp_gene_ids: 2122
strongest_risk_snp: rs1918974
strongest_risk_allele: T
snps: rs1918974
snp_id_current: 1918974
context: intron
pvalue_mlog: 7.096910013008055
ci_95: [0.17-0.37] mm Hg decrease
platform: Affymetrix & Illumina [2,497,993] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19430483?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-05-20
author: Himes BE
date: 2009-05-07
journal: Am J Hum Genet
study: Genome-wide association analysis identifies PDE4D as an asthma-susceptibility gene.
trait: Asthma
initial_samplesize: 359 European ancestry cases, 846 European ancestry controls
region: 5q12.1
chrom: 5
reported_genes: PDE4D
mapped_gene: PDE4D
snp_gene_ids: 5144
strongest_risk_snp: rs1588265
strongest_risk_allele: C
snps: rs1588265
snp_id_current: 1588265
context: intron
pvalue_mlog: 7.522878745280337
ci_95: [1.08-1.30]
platform: Illumina [518,230]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19426955?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

replication_samplesize:
2,981 European ancestry cases, 12,358 European ancestry controls, 769 European ancestry and hispanic cases, 1,007 European ancestry and hispanic controls, 592 Hispanic cases with their 1,184 Hispanic parental controls, 2,258 African American cases, 3,006 African American controls


dbdate: 2009-05-19
author: Sanna S
date: 2009-05-06
journal: Hum Mol Genet
trait: Bilirubin levels
initial_samplesize: 4,300 Sardinian individuals
replication_samplesize: 1,860 Sardinian individuals, 832 Old Order Amish individuals
region: 12p12.2
chrom: 12
reported_genes: SLCO1B3
mapped_gene: SLCO1B3 - SLCO1B7
upstream_gene_id: 28234
downstream_gene_id: 338821
strongest_risk_snp: rs2117032
strongest_risk_allele: C
snps: rs2117032
snp_id_current: 2117032
context: Intergenic
pvalue_mlog: 13.52287874528034
ci_95: [0.08-0.18] s.d. increase
platform: Affymetrix [362,129]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19419973?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Common variants in the SLCO1B3 locus are associated with bilirubin levels and unconjugated hyperbilirubinemia.


dbdate: 2009-05-14
author: Scott LJ
date: 2009-05-05
journal: Proc Natl Acad Sci U S A
study: Genome-wide association and meta-analysis of bipolar disorder in individuals of European ancestry.
trait: Bipolar disorder
initial_samplesize: 3,683 European ancestry cases, 14,507 European ancestry controls
region: 1p32.1
chrom: 1
reported_genes: NF1A
mapped_gene: PGBD4P8 - NFIA
upstream_gene_id: 100421185
downstream_gene_id: 4774
strongest_risk_snp: rs472913
strongest_risk_allele: C
snps: rs472913
snp_id_current: 472913
context: Intergenic
pvalue_mlog: 6.698970004336019
ci_95: [1.11-1.25]
platform: Affymetrix and Illumina [2,366,197] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19416921?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-05-12
author: Johnson AD
date: 2009-05-04
journal: Hum Mol Genet
study: Genome-wide association meta-analysis for total serum bilirubin levels.
trait: Bilirubin levels
initial_samplesize: 9,464 individuals
region: 2q37.1
chrom: 2
reported_genes: UGT1A1
mapped_gene: UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A1;UGT1A3
snp_gene_ids: 54575;54576;54577;54578;54579;54600;54657;54658;54659
strongest_risk_snp: rs6742078
strongest_risk_allele: T
snps: rs6742078
snp_id_current: 6742078
context: intron;intron;intron;intron;intron;intron;intron;intron;intron
pvalue_mlog: 323.301029995664
ci_95: [0.21-0.25] umol/l increase in log(tbil)
platform: Affymetrix & Illumina [2,555,103] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19414484?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-05-07
author: Capasso M
date: 2009-05-03
journal: Nat Genet
study: Common variations in BARD1 influence susceptibility to high-risk neuroblastoma.
trait: Neuroblastoma (high-risk)
initial_samplesize: 397 European ancestry cases, 2,043 European ancestry controls
replication_samplesize: 371 European ancestry cases, 2,119 European ancestry controls
region: 2q35
chrom: 2
reported_genes: BARD1
mapped_gene: BARD1
snp_gene_ids: 580
strongest_risk_snp: rs6435862
strongest_risk_allele: G
snps: rs6435862
snp_id_current: 6435862
context: intron
pvalue_mlog: 17.04575749056067
ci_95: [1.49-1.90]
platform: Illumina [462,866]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19412175?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-05-07
author: Hallmayer J
date: 2009-05-03
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19412176
study: Narcolepsy is strongly associated with the T-cell receptor alpha locus.
trait: Narcolepsy
initial_samplesize: 807 European ancestry cases, 1,074 European ancestry controls
region: 14q11.2
chrom: 14
reported_genes: TRA-alpha, TRAJ10
mapped_gene: TRA
snp_gene_ids: 6955
strongest_risk_snp: rs1154155
strongest_risk_allele: C
snps: rs1154155
snp_id_current: 1154155
pvalue_mlog: 21.52287874528033
ci_95: [1.52-1.88]
platform: Affymetrix [549,596]
cnv: N
replication_samplesize:
363 European ancestry cases, 355 European ancestry  controls, 133 African American cases, 144 African American controls, 561 Asian ancestry cases, 605 Asian ancestry controls


dbdate: 2009-05-07
author: Takeuchi F
date: 2009-04-29
journal: Diabetes
link: http://www.ncbi.nlm.nih.gov/pubmed/19401414
trait: Type 2 diabetes
initial_samplesize: 519 Japanese ancestry cases, 503 Japanese ancestry controls
replication_samplesize: 5,110 Japanese ancestry cases, 6,867 Japanese ancestry controls
region: 6p22.3
chrom: 6
reported_genes: CDKAL1
mapped_gene: CDKAL1
snp_gene_ids: 54901
strongest_risk_snp: rs4712523
strongest_risk_allele: G
snps: rs4712523
snp_id_current: 4712523
context: intron
pvalue_mlog: 19.15490195998574
ci_95: [1.21-1.33]
platform: Illumina [482,625]
cnv: N
study:
Confirmation of multiple risk Loci and genetic impacts by a genome-wide association study of type 2 diabetes in the Japanese population.


dbdate: 2009-05-11
author: Wang K
date: 2009-04-28
journal: Nature
study: Common genetic variants on 5p14.1 associate with autism spectrum disorders.
trait: Autism
region: 5p14.1
chrom: 5
reported_genes: CDH10,CDH9
mapped_gene: MSNP1 - CDH9
upstream_gene_id: 4479
downstream_gene_id: 1007
strongest_risk_snp: rs4307059
strongest_risk_allele: T
snps: rs4307059
snp_id_current: 4307059
context: Intergenic
pvalue_mlog: 9.698970004336017
ci_95: [NR]
platform: Illumina [474,019]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19404256?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

initial_samplesize:
3,101 European ancestry individuals from 780 families, 1,204 European ancestry cases, 6,491 European ancestry controls

replication_samplesize:
1,390 European ancestry individuals from 447 families, 108 European ancestry cases, 540 European ancestry controls


dbdate: 2009-05-05
author: Cho YS
date: 2009-04-26
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19396169
trait: Biomedical quantitative traits
initial_samplesize: 8,842 Korean ancestry individuals
replication_samplesize: 7,861 Korean ancestry individuals
region: 16q12.2
chrom: 16
reported_genes: FTO
mapped_gene: FTO
snp_gene_ids: 79068
strongest_risk_snp: rs9939609
strongest_risk_allele: A
snps: rs9939609
snp_id_current: 9939609
context: intron
pvalue_mlog: 6.698970004336019
ci_95: [0.14-0.32] kg/m2 increase
platform: Affymetrix [2,156,535] (imputed)
cnv: N
study:
A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits.


dbdate: 2009-04-22
author: Poduslo SE
date: 2009-04-14
journal: Am J Med Genet B Neuropsychiatr Genet
trait: Aging
region: 2q22.1
chrom: 2
reported_genes: LRP1B
mapped_gene: LRP1B
snp_gene_ids: 53353
strongest_risk_snp: rs12474609
snps: rs12474609
snp_id_current: 12474609
context: intron
pvalue_mlog: 8.221848749616356
platform: Affymetrix [469,218]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19367585?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
A genome screen of successful aging without cognitive decline identifies LRP1B by haplotype analysis.

initial_samplesize:
89 European ancestry and African American successfully aged individuals, 227 European ancestry Alzheimers cases


dbdate: 2009-05-05
author: Hiura Y
date: 2009-04-10
journal: Circ J
link: http://www.ncbi.nlm.nih.gov/pubmed/19359809
trait: HDL cholesterol
initial_samplesize: 900 Japanese ancestry individuals
replication_samplesize: 1,810 Japanese ancestry individuals
region: 16q13
chrom: 16
reported_genes: CETP
mapped_gene: HERPUD1 - CETP
upstream_gene_id: 9709
downstream_gene_id: 1071
strongest_risk_snp: rs3764261
strongest_risk_allele: A
snps: rs3764261
snp_id_current: 3764261
context: Intergenic
pvalue_mlog: 11.52287874528034
ci_95: mg/dl increase
platform: Illumina [368,274]
cnv: N
study:
Identification of genetic markers associated with high-density lipoprotein-cholesterol by genome-wide screening in a Japanese population: the Suita study.


dbdate: 2009-04-22
author: Mangino M
date: 2009-04-08
journal: J Med Genet
trait: Telomere length
initial_samplesize: 1,625 European ancestry women
replication_samplesize: 1,165 European ancestry individuals
region: 18q12.2
chrom: 18
reported_genes: BRUNOL4, PIKC3C
mapped_gene: CELF4 - MIR4318
upstream_gene_id: 56853
downstream_gene_id: 100422857
strongest_risk_snp: rs2162440
strongest_risk_allele: G
snps: rs2162440
snp_id_current: 2162440
context: Intergenic
pvalue_mlog: 5.522878745280337
ci_95: [62.88-149.12] base pairs shorter
platform: Illumina [~314,075]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19359265?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
A genome-wide association study identifies a novel locus on chromosome 18q12.2 influencing white cell telomere length.


dbdate: 2009-04-14
author: Esparza-Gordillo J
date: 2009-04-06
journal: Nat Genet
study: A common variant on chromosome 11q13 is associated with atopic dermatitis.
trait: Atopic dermatitis
replication_samplesize: 2,637 European ancestry cases, 3,957 European ancestry controls
region: 11q13.5
chrom: 11
reported_genes: C11orf30
mapped_gene: C11orf30 - LRRC32
upstream_gene_id: 56946
downstream_gene_id: 2615
strongest_risk_snp: rs7927894
strongest_risk_allele: A
snps: rs7927894
snp_id_current: 7927894
context: Intergenic
pvalue_mlog: 9.096910013008054
ci_95: [1.15-1.30]
platform: Affymetrix [342,303]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19349984?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

initial_samplesize:
939 European ancestry cases, 975 European ancestry controls, 1,097 European ancestry individuals from 270 families


dbdate: 2009-04-16
author: Kamatani Y
date: 2009-04-06
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19349983
trait: Hepatitis B
initial_samplesize: 179 Japanese ancestry cases, 934 Japanese ancestry controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DPB1
mapped_gene: HLA-DPB1
snp_gene_ids: 3115
strongest_risk_snp: rs9277535
strongest_risk_allele: G
snps: rs9277535
snp_id_current: 9277535
context: UTR-3
pvalue_mlog: 38.22184874961635
ci_95: [1.61-1.92]
platform: Illumina [499,544]
cnv: N
study:
A genome-wide association study identifies variants in the HLA-DP locus associated with chronic hepatitis B in Asians.

replication_samplesize:
1,599 Japanese ancestry cases, 2,821 Japanese ancestry controls, 308 Thai ancestry cases, 546 Thai ancestry controls


dbdate: 2009-04-22
author: Soranzo N
date: 2009-04-03
journal: PLoS Genet
trait: Height
initial_samplesize: 12,611 European ancestry individuals
replication_samplesize: 7,187 European ancestry individuals
region: 1p36.11
chrom: 1
reported_genes: CATSPER4
mapped_gene: CATSPER4
snp_gene_ids: 378807
strongest_risk_snp: rs11809207
snps: rs11809207
snp_id_current: 11809207
context: intron
pvalue_mlog: 7.221848749616355
ci_95: [0.04-0.10] s.d. increase
platform: Illumina [229,216]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19343178?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Meta-analysis of genome-wide scans for human adult stature identifies novel Loci and associations with measures of skeletal frame size.


dbdate: 2009-04-13
author: Nan H
date: 2009-04-02
journal: J Invest Dermatol
study: Genome-wide association study of tanning phenotype in a population of European ancestry.
trait: Tanning
initial_samplesize: 2,287 European ancestry women
replication_samplesize: 870 European ancestry women
region: 5p13.2
chrom: 5
reported_genes: MATP
mapped_gene: SLC45A2
snp_gene_ids: 51151
strongest_risk_snp: rs35391
strongest_risk_allele: T
snps: rs35391
snp_id_current: 35391
context: intron
pvalue_mlog: 9.522878745280336
ci_95: [0.30-0.58] decrease in tanning ability score
platform: Illumina [528,173]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19340012?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-12-29
author: Danik JS
date: 2009-04-01
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20031577
trait: Fibrinogen
initial_samplesize: 17,686 European ancestry women
region: 1q21.3
chrom: 1
reported_genes: IL6R
mapped_gene: IL6R
snp_gene_ids: 3570
strongest_risk_snp: rs8192284
strongest_risk_allele: C
snps: rs8192284
snp_id_current: 2228145
context: missense
pvalue_mlog: 10.69897000433602
ci_95: [NR] mg/dl decrease
platform: Illumina [337,343]
cnv: N
study:
Novel loci, including those related to Crohn disease, psoriasis, and inflammation, identified in a genome-wide association study of fibrinogen in 17 686 women: the Women's Genome Health Study.


dbdate: 2009-12-29
author: Dehghan A
date: 2009-04-01
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20031576
trait: Fibrinogen
initial_samplesize: 22,096 European ancestry individuals
replication_samplesize: 17,686 European ancestry women
region: 4q31.3
chrom: 4
reported_genes: FGB
mapped_gene: FGB
snp_gene_ids: 2244
strongest_risk_snp: rs1800789
strongest_risk_allele: A
snps: rs1800789
snp_id_current: 1800789
context: nearGene-5
pvalue_mlog: 29.69897000433602
ci_95: [0.07-0.11] g/L increase
platform: Affymetrix & Illumina [~2,661,766] (imputed)
cnv: N
study:
Association of novel genetic Loci with circulating fibrinogen levels: a genome-wide association study in 6 population-based cohorts.


dbdate: 2009-12-29
author: Pare G
date: 2009-04-01
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/20031578
trait: Homocysteine levels
initial_samplesize: 13,974 European ancestry females
replication_samplesize: 840 European ancestry females
region: 1p36.22
chrom: 1
reported_genes: MTHFR
mapped_gene: MTHFR
snp_gene_ids: 4524
strongest_risk_snp: rs1801133
strongest_risk_allele: A
snps: rs1801133
snp_id_current: 1801133
context: missense
pvalue_mlog: 34.09691001300806
ci_95: [NR] unit increase in log(homocysteine)
platform: Illumina [336,469]
cnv: N
study:
Novel associations of CPS1, MUT, NOX4, and DPEP1 with plasma homocysteine in a healthy population: a genome-wide evaluation of 13 974 participants in the Women's Genome Health Study.


dbdate: 2009-04-03
author: Thomas G
date: 2009-03-29
journal: Nat Genet
trait: Breast cancer
initial_samplesize: 1,145 European ancestry cases, 1,142 European ancestry controls
replication_samplesize: 8,625 European ancestry cases, 9,657 European ancestry controls
region: 10q26.13
chrom: 10
reported_genes: FGFR2
mapped_gene: FGFR2
snp_gene_ids: 2263
strongest_risk_snp: rs2981579
strongest_risk_allele: T
snps: rs2981579
snp_id_current: 2981579
context: intron
pvalue_mlog: 9.698970004336017
ci_95: [1.07-1.27]
platform: Illumina [528,173]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19330030?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
A multistage genome-wide association study in breast cancer identifies two new risk alleles at 1p11.2 and 14q24.1 (RAD51L1).


dbdate: 2009-03-31
author: Newton-Cheh C
date: 2009-03-22
journal: Nat Genet
study: Common variants at ten loci influence QT interval duration in the QTGEN Study.
trait: QT interval
initial_samplesize: 13,685 European ancestry individuals
replication_samplesize: 15,854 European ancestry individuals
region: 1q23.3
chrom: 1
reported_genes: NOS1AP
mapped_gene: OLFML2B - NOS1AP
upstream_gene_id: 25903
downstream_gene_id: 9722
strongest_risk_snp: rs12143842
strongest_risk_allele: T
snps: rs12143842
snp_id_current: 12143842
context: Intergenic
pvalue_mlog: 77.698970004336
ci_95: [2.81-3.49] msec increase
platform: Affymetrix and Illumina [up to 2,543,686] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19305408?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-04-02
author: Pfeufer A
date: 2009-03-22
journal: Nat Genet
study: Common variants at ten loci modulate the QT interval duration in the QTSCD Study.
trait: QT interval
initial_samplesize: 15,842 European ancestry individuals
replication_samplesize: up to 13,602 individuals
region: 1p36.31
chrom: 1
reported_genes: RNF207
mapped_gene: RNF207
snp_gene_ids: 388591
strongest_risk_snp: rs846111
strongest_risk_allele: C
snps: rs846111
snp_id_current: 846111
context: missense
pvalue_mlog: 15.39794000867204
ci_95: [1.00-1.98] ms increase
platform: Affymetrix and Illumina [unsure] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19305409?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-04-02
author: Org E
date: 2009-03-20
journal: Hum Mol Genet
trait: Hypertension
initial_samplesize: 364 European ancestry cases, 590 European ancestry controls
replication_samplesize: 1,043 European ancestry cases, 1,769 European ancestry controls
region: 16q23.3
chrom: 16
reported_genes: CDH13
mapped_gene: MPHOSPH6 - CDH13
upstream_gene_id: 10200
downstream_gene_id: 1012
strongest_risk_snp: rs11646213
strongest_risk_allele: T
snps: rs11646213
snp_id_current: 11646213
context: Intergenic
pvalue_mlog: 5.096910013008055
ci_95: [1.15-1.43]
platform: Affymetrix [395,912]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19304780?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide scan identifies CDH13 as a novel susceptibility locus contributing to blood pressure determination in two European populations.


dbdate: 2009-03-31
author: Pillai SG
date: 2009-03-20
journal: PLoS Genet
trait: Chronic obstructive pulmonary disease
initial_samplesize: 823 cases, 810 controls
region: 15q25.1
chrom: 15
reported_genes: CHRNA3,CHRNA4,CHRNA5, LOC123688
mapped_gene: HYKK
snp_gene_ids: 123688
strongest_risk_snp: rs8034191
strongest_risk_allele: C
snps: rs8034191
snp_id_current: 8034191
context: intron
pvalue_mlog: 10
ci_95: [1.18-1.67]
platform: Illumina [493,609]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19300482?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
A genome-wide association study in chronic obstructive pulmonary disease (COPD): identification of two major susceptibility loci.

replication_samplesize:
1,891 European ancestry individuals from 606 families, 389 European ancestry cases, 472 European ancestry controls, 949 individuals from 127 families


dbdate: 2009-03-30
author: Takeuchi F
date: 2009-03-20
journal: PLoS Genet
trait: Warfarin maintenance dose
initial_samplesize: 1,053 European ancestry individuals
replication_samplesize: 588 European ancestry individuals
region: 16p11.2
chrom: 16
reported_genes: VKORC1
mapped_gene: VKORC1
snp_gene_ids: 79001
strongest_risk_snp: rs9923231
strongest_risk_allele: T
snps: rs9923231
snp_id_current: 9923231
context: nearGene-5
pvalue_mlog: 180.5228787452803
ci_95: [0.91-1.02] mg/week decrease
platform: Illumina [325,997]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19300499?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
A genome-wide association study confirms VKORC1, CYP2C9, and CYP4F2 as principal genetic determinants of warfarin dose.


dbdate: 2009-03-31
author: Wilk JB
date: 2009-03-20
journal: PLoS Genet
study: A genome-wide association study of pulmonary function measures in the Framingham Heart Study.
trait: Pulmonary function
initial_samplesize: 7,691 European ancestry individuals
replication_samplesize: 835 European ancestry individuals
region: 4q31.21
chrom: 4
reported_genes: HHIP
mapped_gene: GYPA - KRT18P51
upstream_gene_id: 2993
downstream_gene_id: 391703
strongest_risk_snp: rs13147758
strongest_risk_allele: G
snps: rs13147758
snp_id_current: 13147758
context: Intergenic
pvalue_mlog: 10.09691001300805
ci_95: [NR] % increase in FEV1/FVC ratio
platform: Affymetrix [2,540,223] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19300500?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-04-01
author: Tanaka T
date: 2009-03-18
journal: Am J Hum Genet
trait: Folate pathway vitamin levels
initial_samplesize: 2,934 European ancestry individuals
replication_samplesize: 686 European ancestry individuals
region: 1p36.12
chrom: 1
reported_genes: ALPL
mapped_gene: NBPF3
snp_gene_ids: 84224
strongest_risk_snp: rs4654748
strongest_risk_allele: C
snps: rs4654748
snp_id_current: 4654748
context: intron
pvalue_mlog: 17.09691001300806
ci_95: [0.90-2.00] ng/ml decrease
platform: Affymetrix and Illumina [~2.5 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19303062?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association study of vitamin B6, vitamin B12, folate, and homocysteine blood concentrations.


dbdate: 2009-03-31
author: Kilpivaara O
date: 2009-03-15
journal: Nat Genet
trait: Myeloproliferative neoplasms
initial_samplesize: 324 European ancestry cases, 2,999 European ancestry controls
region: 9p24.1
chrom: 9
reported_genes: JAK2
mapped_gene: JAK2
snp_gene_ids: 3717
strongest_risk_snp: rs10974944
snps: rs10974944
snp_id_current: 10974944
context: intron
pvalue_mlog: 19.39794000867203
ci_95: [2.40-4.00]
platform: Affymetrix [62,775]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19287384?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
A germline JAK2 SNP is associated with predisposition to the development of JAK2(V617F)-positive myeloproliferative neoplasms.


dbdate: 2009-03-31
author: Cui J
date: 2009-03-14
journal: Mol Med
trait: Anti-cyclic Citrullinated Peptide Antibody
initial_samplesize: 531 European ancestry cases
replication_samplesize: 849 European ancestry cases
region: 6p21.32
chrom: 6
reported_genes: HLA-DRA, BTNL2
mapped_gene: BTNL2
snp_gene_ids: 56244
strongest_risk_snp: rs1980493
snps: rs1980493
snp_id_current: 1980493
context: intron
pvalue_mlog: 6.30102999566398
platform: Affymetrix [97,248]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19287509?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association study of determinants of anti-cyclic citrullinated peptide antibody titer in adults with rheumatoid arthritis.


dbdate: 2009-03-30
author: Tregouet DA
date: 2009-03-10
journal: Blood
trait: Venous thromboembolism
initial_samplesize: 419 European ancestry cases, 1,228 European ancestry controls
replication_samplesize: 1,757 European ancestry cases, 1,480 European ancestry controls
region: 9q34.2
chrom: 9
reported_genes: ABO
mapped_gene: ABO
snp_gene_ids: 28
strongest_risk_snp: rs505922
strongest_risk_allele: C
snps: rs505922
snp_id_current: 505922
context: intron
pvalue_mlog: 14.39794000867204
ci_95: [1.56-2.11]
platform: Illumina [291,872]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19278955?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Common susceptibility alleles are unlikely to contribute as strongly as the FV and ABO loci to VTE risk: results from a GWAS approach.


dbdate: 2009-03-28
author: Birnbaum S
date: 2009-03-08
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19270707
trait: Orofacial clefts
initial_samplesize: 224 European ancestry cases, 383 European ancestry controls
replication_samplesize: 246 cases, 954 controls
region: 8q24.21
chrom: 8
reported_genes: PVT1, GSDMC
mapped_gene: LINC01263 - LINC00977
upstream_gene_id: 101927774
downstream_gene_id: 728724
strongest_risk_snp: rs987525
strongest_risk_allele: A
snps: rs987525
snp_id_current: 987525
context: Intergenic
pvalue_mlog: 23.52287874528033
ci_95: [2.02-3.26]
platform: Illumina [521,176]
cnv: N
study:
Key susceptibility locus for nonsyndromic cleft lip with or without cleft palate on chromosome 8q24.


dbdate: 2009-03-24
author: Liu XG
date: 2009-03-04
journal: Am J Hum Genet
trait: Body mass (lean)
initial_samplesize: 973 European ancestry individuals
region: 8q23.1
chrom: 8
reported_genes: TRHR
mapped_gene: TRHR
snp_gene_ids: 7201
strongest_risk_snp: rs7832552
strongest_risk_allele: T
snps: rs7832552
snp_id_current: 7832552
context: intron
pvalue_mlog: 9.397940008672037
ci_95: [0.04-0.16] kg increase
platform: Affymetrix [379,319]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19268274?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association and replication studies identified TRHR as an important gene for lean body mass.

replication_samplesize:
1,488 European ancestry individuals,  1,972 European ancestry individuals from 593 families, 2,955 Chinese ancestry individuals


dbdate: 2009-04-01
author: Caporaso N
date: 2009-02-27
journal: PLoS One
study: Genome-wide and candidate gene association study of cigarette smoking behaviors.
trait: Smoking behavior
initial_samplesize: 2,617 European ancestry smokers, 1,725 European ancestry controls
region: 3q13.12
chrom: 3
reported_genes: BBX
mapped_gene: BBX
snp_gene_ids: 56987
strongest_risk_snp: rs6437740
snps: rs6437740
snp_id_current: 6437740
context: intron
pvalue_mlog: 6.698970004336019
ci_95: [NR] fewer cigarettes per day
platform: Illumina [~518,000]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19247474?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-03-18
author: Xiong DH
date: 2009-02-25
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19249006
trait: Bone mineral density
initial_samplesize: 1,000 European ancestry individuals
region: 16q23.1
chrom: 16
reported_genes: ADAMTS18
mapped_gene: ADAMTS18
snp_gene_ids: 170692
strongest_risk_snp: rs11864477
strongest_risk_allele: C
snps: rs11864477
snp_id_current: 11864477
context: intron
pvalue_mlog: 7.698970004336018
ci_95: % [NR] of variance explained
platform: Affymetrix [379,319]
cnv: N
study:
Genome-wide association and follow-up replication studies identified ADAMTS18 and TGFBR3 as bone mass candidate genes in different ethnic groups.

replication_samplesize:
4,925 European ancestry individuals, 350 Chinese ancestry hip fracture cases, 350 Chinese ancestry hip fracture controls, 2,955 Chinese ancestry individuals, 908 West African ancestry men


dbdate: 2009-03-01
author: Schrauwen I
date: 2009-02-18
journal: Am J Hum Genet
study: A genome-wide analysis identifies genetic variants in the RELN gene associated with otosclerosis.
trait: Otosclerosis
initial_samplesize: 302 cases, 302 controls
replication_samplesize: 847 cases, 872 controls
region: 7q22.1
chrom: 7
reported_genes: RELN
mapped_gene: RELN
snp_gene_ids: 5649
strongest_risk_snp: rs3914132
snps: rs3914132
snp_id_current: 3914132
context: intron
pvalue_mlog: 7.698970004336018
ci_95: [1.32-1.79]
platform: Illumina [~555,000] (pooled)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19230858?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-05-07
author: Smith JG
date: 2009-02-15
journal: Heart Rhythm
link: http://www.ncbi.nlm.nih.gov/pubmed/19389651
trait: Electrocardiographic conduction measures
initial_samplesize: 1,262 Kosraen individuals
region: 3p22.2
chrom: 3
reported_genes: SCN5A
mapped_gene: SCN5A
snp_gene_ids: 6331
strongest_risk_snp: rs7638909
strongest_risk_allele: G
snps: rs7638909
snp_id_current: 7638909
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [2.84-6.76] ms increase
platform: Affymetrix [338,049]
cnv: N
study:
Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae.


dbdate: 2009-02-28
author: Zheng W
date: 2009-02-15
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19219042
study: Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1.
trait: Breast cancer
initial_samplesize: 1,505 Chinese ancestry cases, 1,522 Chinese ancestry controls
region: 6q25.1
chrom: 6
reported_genes: ESR1, C6orf97
mapped_gene: CCDC170 - ESR1
upstream_gene_id: 80129
downstream_gene_id: 2099
strongest_risk_snp: rs2046210
strongest_risk_allele: A
snps: rs2046210
snp_id_current: 2046210
context: Intergenic
pvalue_mlog: 14.69897000433602
ci_95: [1.21-1.37]
platform: Affymetrix [up to 607,728]
cnv: N
replication_samplesize:
5,026 Chinese ancestry cases, 2,476 Chinese ancestry controls, 1,591 European ancestry cases, 1,466 European ancestry controls


dbdate: 2009-02-28
author: Soranzo N
date: 2009-02-12
journal: Blood
study: A novel variant on chromosome 7q22.3 associated with mean platelet volume, counts, and function.
trait: Mean platelet volume
initial_samplesize: 1,221 individuals
replication_samplesize: 7,365 individuals
region: 7q22.3
chrom: 7
reported_genes: Intergenic
mapped_gene: CCDC71L - RNA5SP236
upstream_gene_id: 168455
downstream_gene_id: 100873494
strongest_risk_snp: rs342293
strongest_risk_allele: G
snps: rs342293
snp_id_current: 342293
context: Intergenic
pvalue_mlog: 24
ci_95: [0.014-0.018] log fl increase
platform: Affymetrix [361,352]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19221038?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-03-01
author: Erdmann J
date: 2009-02-08
journal: Nat Genet
study: New susceptibility locus for coronary artery disease on chromosome 3q22.3.
trait: Coronary heart disease
initial_samplesize: 1,222 European ancestry cases, 1,298 European ancestry controls
replication_samplesize: 18,185 European ancestry cases, 20,068 European ancestry controls
region: 3q22.3
chrom: 3
reported_genes: MRAS
mapped_gene: MRAS
snp_gene_ids: 22808
strongest_risk_snp: rs9818870
strongest_risk_allele: T
snps: rs9818870
snp_id_current: 9818870
context: UTR-3
pvalue_mlog: 12.15490195998574
ci_95: [1.11-1.19]
platform: Affymetrix [567,119]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19198612?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-03-01
author: Kathiresan S
date: 2009-02-08
journal: Nat Genet
trait: Myocardial infarction (early onset)
initial_samplesize: 2,967 European ancestry cases, 3,075 European ancestry controls
replication_samplesize: 9,746 European ancestry cases, 9,746 European ancestry controls
region: 9p21.3
chrom: 9
reported_genes: CDKN2A, CDKN2B
mapped_gene: CDKN2B-AS1
snp_gene_ids: 100048912
strongest_risk_snp: rs4977574
strongest_risk_allele: G
snps: rs4977574
snp_id_current: 4977574
context: intron
pvalue_mlog: 43.52287874528033
ci_95: [1.25-1.34]
platform: Affymetrix [~2.5 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19198609?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants.


dbdate: 2009-02-28
author: Gudmundsson J
date: 2009-02-06
journal: Nat Genet
study: Common variants on 9q22.33 and 14q13.3 predispose to thyroid cancer in European populations.
trait: Thyroid cancer
initial_samplesize: 192 European ancestry cases, 37,196 European ancestry controls
replication_samplesize: 432 European ancestry cases, 1,727 European ancestry controls
region: 9q22.33
chrom: 9
reported_genes: FOXE1
mapped_gene: KRT18P13 - FOXE1
upstream_gene_id: 392371
downstream_gene_id: 2304
strongest_risk_snp: rs965513
strongest_risk_allele: A
snps: rs965513
snp_id_current: 965513
context: Intergenic
pvalue_mlog: 26.69897000433602
ci_95: [1.59-1.94]
platform: Illumina [304,083]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19198613?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-10-15
author: Lowe JK
date: 2009-02-06
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19197348
trait: Quantitative traits
initial_samplesize: 2,906 Kosraen individuals
region: 10p15.3
chrom: 10
reported_genes: ADARB2
mapped_gene: ADARB2
snp_gene_ids: 105
strongest_risk_snp: rs6560749
strongest_risk_allele: T
snps: rs6560749
snp_id_current: 6560749
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [NR] kg/m2 decrease
platform: Affymetrix [408,775]
cnv: N
study:
Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae.


dbdate: 2009-02-28
author: Kim SH
date: 2009-02-01
journal: Clin Exp Allergy
link: http://www.ncbi.nlm.nih.gov/pubmed/19187332
trait: Asthma (toluene diisocyanate-induced)
initial_samplesize: 84 Korean ancestry cases, 263 Korean ancestry controls
region: 13q12.13
chrom: 13
reported_genes: Intergenic
mapped_gene: GPR12 - FGFR1OP2P1
upstream_gene_id: 2835
downstream_gene_id: 100873883
strongest_risk_snp: rs9319321
strongest_risk_allele: T
snps: rs9319321
snp_id_current: 9319321
context: Intergenic
pvalue_mlog: 5.522878745280337
ci_95: [2.47-10.92]
platform: Affymetrix [312,978]
cnv: N
study:
Alpha-T-catenin (CTNNA3) gene was identified as a risk variant for toluene diisocyanate-induced asthma by genome-wide association analysis.


dbdate: 2009-03-30
author: Polasek O
date: 2009-02-01
journal: Croat Med J
study: Genome-wide association study of anthropometric traits in Korcula Island, Croatia.
trait: Anthropometric traits
initial_samplesize: 898 Korculan's individuals
region: 1p36.32
chrom: 1
reported_genes: Intergenic
mapped_gene: AJAP1 - MIR4417
upstream_gene_id: 55966
downstream_gene_id: 100616489
strongest_risk_snp: rs7513590
snps: rs7513590
snp_id_current: 7513590
context: Intergenic
pvalue_mlog: 5.301029995663981
ci_95: [0.17-0.45] mm decrease
platform: Illumina [316,730]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19260139?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-12-29
author: Ridker PM
date: 2009-02-01
journal: Circ Cardiovasc Genet
trait: HDL cholesterol
initial_samplesize: 18,245 European ancestry females
region: 16q13
chrom: 16
reported_genes: CETP, NUP93, SLC12A3, HERPUD1
mapped_gene: CETP
snp_gene_ids: 1071
strongest_risk_snp: rs1800775
strongest_risk_allele: A
snps: rs1800775
snp_id_current: 1800775
context: nearGene-5
pvalue_mlog: 92.39794000867202
ci_95: mg/dL increase
platform: Illumina [~318,237]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/20031564?itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_RVDocSum&ordinalpos=6

study:
Polymorphism in the CETP gene region, HDL cholesterol, and risk of future myocardial infarction: Genomewide analysis among 18 245 initially healthy women from the Women's Genome Health Study.


dbdate: 2009-02-25
author: Stefansson H
date: 2009-02-01
journal: Nat Genet
study: Variant in the sequence of the LINGO1 gene confers risk of essential tremor.
trait: Essential tremor
initial_samplesize: 452 European ancestry cases, 14,378 European ancestry controls
replication_samplesize: 301 European ancestry cases, 1,419 European ancestry controls
region: 15q24.3
chrom: 15
reported_genes: LINGO1
mapped_gene: LINGO1
snp_gene_ids: 84894
strongest_risk_snp: rs9652490
strongest_risk_allele: G
snps: rs9652490
snp_id_current: 9652490
context: intron
pvalue_mlog: 8.999999999999998
ci_95: [1.35-1.79]
platform: Illumina [305,624]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19182806?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-03-31
author: Zemunik T
date: 2009-02-01
journal: Croat Med J
study: Genome-wide association study of biochemical traits in Korcula Island, Croatia.
trait: Biochemical measures
initial_samplesize: 898 Korculan individuals
region: 12q21.33
chrom: 12
reported_genes: Intergenic
mapped_gene: DCN - C12orf79
upstream_gene_id: 1634
downstream_gene_id: 256021
strongest_risk_snp: rs10777332
strongest_risk_allele: A
snps: rs10777332
snp_id_current: 10777332
context: Intergenic
pvalue_mlog: 5.301029995663981
ci_95: [0.14-0.34] mmol/L decrease
platform: Illumina [316,730]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19260141?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-02-28
author: Ferrucci L
date: 2009-01-29
journal: Am J Hum Genet
trait: Carotenoid and tocopherol levels
initial_samplesize: 1,191 European ancestry individuals
replication_samplesize: 2,540 European ancestry individuals, 211 individuals
region: 16q23.2
chrom: 16
reported_genes: BCMO1
mapped_gene: PKD1L2 - BCMO1
upstream_gene_id: 114780
downstream_gene_id: 53630
strongest_risk_snp: rs6564851
strongest_risk_allele: G
snps: rs6564851
snp_id_current: 6564851
context: Intergenic
pvalue_mlog: 23.69897000433602
ci_95: [0.120-0.177] umol/L increase
platform: Illumina [~500,451]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19185284?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Common variation in the beta-carotene 15,15'-monooxygenase 1 gene affects circulating levels of carotenoids: a genome-wide association study.


dbdate: 2009-02-26
author: Yang JJ
date: 2009-01-28
journal: JAMA
trait: Response to treatment for acute lymphoblastic leukemia
initial_samplesize: 356 European ancestry cases, 53 Black cases, 78 Other ancestry cases
region: 10p12.33
chrom: 10
reported_genes: ST8SIA6
mapped_gene: ST8SIA6
snp_gene_ids: 338596
strongest_risk_snp: rs359312
strongest_risk_allele: T
snps: rs359312
snp_id_current: 359312
context: intron
pvalue_mlog: 7.045757490560674
ci_95: [1.52-10.10]
platform: Affymetrix [476,796]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19176441?ordinalpos=9&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide interrogation of germline genetic variation associated with treatment response in childhood acute lymphoblastic leukemia.


dbdate: 2009-02-06
author: Nair RP
date: 2009-01-25
journal: Nat Genet
study: Genome-wide scan reveals association of psoriasis with IL-23 and NF-kappaB pathways.
trait: Psoriasis
initial_samplesize: 1,359 European ancestry cases, 1,400 European ancestry controls
replication_samplesize: 5,048 European ancestry cases, 5,041 European ancestry controls
region: 6p21.33
chrom: 6
reported_genes: HLA-C
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs12191877
strongest_risk_allele: T
snps: rs12191877
snp_id_current: 12191877
pvalue_mlog: 100
ci_95: [NR]
platform: Perlegen [~2.5 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19169254?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-02-07
author: Zhang XJ
date: 2009-01-25
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19169255
trait: Psoriasis
initial_samplesize: 1,139 Han Chinese ancestry cases, 1,132 Han Chinese ancestry controls
replication_samplesize: 5,721 Chinese ancestry cases, 7,340 Chinese ancestry controls
region: 1q21.3
chrom: 1
reported_genes: LCE3D, LCE3A
mapped_gene: LCE3E - LCE3D
upstream_gene_id: 353145
downstream_gene_id: 84648
strongest_risk_snp: rs4085613
strongest_risk_allele: A
snps: rs4085613
snp_id_current: 4085613
context: Intergenic
pvalue_mlog: 29.15490195998574
ci_95: [1.25-1.39]
platform: Illumina [494,902]
cnv: N
study:
Psoriasis genome-wide association study identifies susceptibility variants within LCE gene cluster at 1q21.


dbdate: 2009-02-25
author: Ling H
date: 2009-01-22
journal: Obesity (Silver Spring)
trait: Adiponectin levels
initial_samplesize: 997 European ancestry cases, 989 European ancestry controls
region: 3q27.3
chrom: 3
reported_genes: ADIPOQ
mapped_gene: ADIPOQ;ADIPOQ-AS1
snp_gene_ids: 9370;100874095
strongest_risk_snp: rs6773957
strongest_risk_allele: A
snps: rs6773957
snp_id_current: 6773957
context: UTR-3;ncRNA
pvalue_mlog: 7.30102999566398
platform: Affymetrix [398,625]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19165155?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide linkage and association analyses to identify genes influencing adiponectin levels: the GEMS Study.


dbdate: 2009-03-03
author: Meyre D
date: 2009-01-18
journal: Nat Genet
trait: Obesity
region: 16q12.2
chrom: 16
reported_genes: FTO
mapped_gene: FTO
snp_gene_ids: 79068
strongest_risk_snp: rs1421085
strongest_risk_allele: C
snps: rs1421085
snp_id_current: 1421085
context: intron
pvalue_mlog: 28
ci_95: [1.27-1.51]
platform: Illumina [308,846]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19151714?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations.

initial_samplesize:
695 European ancestry obese adults, 731 European ancestry lean adults, 685 European ancestry obese children, 685 European ancestry lean children

replication_samplesize:
1,171 European ancestry obese adults, 1,114 European ancestry lean adults, 4,417 European ancestry adults, 856 European ancestry obese children, European ancestry 1,297 lean children and young adults, 5,291 European ancestry children


dbdate: 2009-02-27
author: Carrasquillo MM
date: 2009-01-11
journal: Nat Genet
study: Genetic variation in PCDH11X is associated with susceptibility to late-onset Alzheimer's disease.
trait: Alzheimer's disease
initial_samplesize: 844 European ancestry cases, 1,255 European ancestry controls
replication_samplesize: 1,547 European ancestry cases, 1,209 European ancestry controls
region: Xq21.31
chrom: 23
reported_genes: PCDH11X
mapped_gene: PCDH11X
snp_gene_ids: 27328
strongest_risk_snp: rs2573905
snps: rs2573905
snp_id_current: 2573905
context: intron
pvalue_mlog: 6.698970004336019
ci_95: [1.17-1.42]
platform: Illumina [313,504]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19136949?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-01-21
author: Burgner D
date: 2009-01-09
journal: PLoS Genet
trait: Kawasaki disease
initial_samplesize: 107 European ancestry cases, 134 European ancestry controls
replication_samplesize: 583 European ancestry cases, 1,357 European ancestry controls from 583 families
region: 3q26.31
chrom: 3
reported_genes: NAALADL2
mapped_gene: NAALADL2
snp_gene_ids: 254827
strongest_risk_snp: rs17531088
strongest_risk_allele: T
snps: rs17531088
snp_id_current: 17531088
context: intron
pvalue_mlog: 5.999999999999999
ci_95: [1.32-1.53]
platform: Affymetrix [223,922]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19132087?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
A genome-wide association study identifies novel and functionally related susceptibility Loci for Kawasaki disease.


dbdate: 2009-02-25
author: Feulner TM
date: 2009-01-07
journal: Mol Psychiatry
study: Examination of the current top candidate genes for AD in a genome-wide association study.
trait: Alzheimer's disease
initial_samplesize: 491 European ancestry cases, 479 European ancestry controls
region: 19q13.32
chrom: 19
reported_genes: TOMM40, APOE
mapped_gene: TOMM40
snp_gene_ids: 10452
strongest_risk_snp: rs157580
snps: rs157580
snp_id_current: 157580
context: intron
pvalue_mlog: 40
platform: Illumina [~550,000]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19125160?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-01-21
author: Ober C
date: 2009-01-07
journal: J Lipid Res
trait: Lp (a) levels
initial_samplesize: 357 Hutterite individuals
replication_samplesize: 1,054 European ancestry males
region: 6q25.3
chrom: 6
reported_genes: LPA
mapped_gene: LPA
snp_gene_ids: 4018
strongest_risk_snp: rs6919346
snps: rs6919346
snp_id_current: 6919346
context: intron
pvalue_mlog: 10.39794000867204
ci_95: [mg/dl decrease]
platform: Affymetrix [290,327]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19124843?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association study of plasma lipoprotein(a) levels identifies multiple genes on chromosome 6q.


dbdate: 2009-01-21
author: Silverberg MS
date: 2009-01-04
journal: Nat Genet
study: Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
trait: Ulcerative colitis
initial_samplesize: 1,022 European ancestry cases, 2,503 European ancestry controls
replication_samplesize: 1,387 European ancestry cases, 1,115 European ancestry controls
region: 1p36.13
chrom: 1
reported_genes: RNF186
mapped_gene: RNF186
snp_gene_ids: 54546
strongest_risk_snp: rs3806308
snps: rs3806308
snp_id_current: 3806308
context: nearGene-5
pvalue_mlog: 8.154901959985743
platform: Illumina [280,748]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19122664?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-01-21
author: Beecham GW
date: 2009-01-03
journal: Am J Hum Genet
trait: Alzheimer's disease
initial_samplesize: 492 European ancestry cases, 496 European ancestry controls
replication_samplesize: 238 European ancestry cases, 220 European ancestry controls
region: 12q13.11
chrom: 12
reported_genes: FAM113B
mapped_gene: PCED1B-AS1 - MIR4494
upstream_gene_id: 100233209
downstream_gene_id: 100616478
strongest_risk_snp: rs11610206
snps: rs11610206
snp_id_current: 11610206
context: Intergenic
pvalue_mlog: 6.522878745280337
platform: Illumina [~2.5 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19118814?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association study implicates a chromosome 12 risk locus for late-onset Alzheimer disease.


dbdate: 2009-02-27
author: Hinks A
date: 2009-01-01
journal: Arthritis Rheum
trait: Arthritis (juvenile idiopathic)
initial_samplesize: 279 European ancestry cases, 184 European ancestry controls
replication_samplesize: up to 654 European ancestry cases, 2,024 European ancestry controls
region: 1p13.1
chrom: 1
reported_genes: VTCN1
mapped_gene: VTCN1
snp_gene_ids: 79679
strongest_risk_snp: rs12046117
snps: rs12046117
snp_id_current: 12046117
context: intron
pvalue_mlog: 5.999999999999999
ci_95: [1.29-1.94]
platform: Affymetrix [88,862]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19116933?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Identification of a novel susceptibility locus for juvenile idiopathic arthritis by genome-wide association analysis.


dbdate: 2009-01-16
author: Limou S
date: 2009-01-01
journal: J Infect Dis
trait: AIDS progression
replication_samplesize: (see Fellay 2007)
region: 6p21.33
chrom: 6
reported_genes: HCP5, MICB, MCCD1, BAT1, LTB, TNF
mapped_gene: HCP5
snp_gene_ids: 10866
strongest_risk_snp: rs2395029
strongest_risk_allele: G
snps: rs2395029
snp_id_current: 2395029
context: ncRNA
pvalue_mlog: 18.52287874528033
ci_95: [2.39-5.04]
platform: Illumina [291,119]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19115949?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genomewide association study of an AIDS-nonprogression cohort emphasizes the role played by HLA genes (ANRS Genomewide Association Study 02).

initial_samplesize:
275 European ancestry seropositive non-progressors, 86 European ancestry seropositive rapid progressors, 1,352 European ancestry seronegative controls


dbdate: 2009-02-26
author: Sun J
date: 2009-01-01
journal: Cancer Res
study: Sequence variants at 22q13 are associated with prostate cancer risk.
trait: Prostate cancer
initial_samplesize: 1,235 European ancestry aggressive cases, 1,599 European ancestry controls
region: 22q13.1
chrom: 22
reported_genes: TNRC6B
mapped_gene: TNRC6B
snp_gene_ids: 23112
strongest_risk_snp: rs9623117
strongest_risk_allele: C
snps: rs9623117
snp_id_current: 9623117
context: intron
pvalue_mlog: 6.30102999566398
ci_95: [1.11-1.26]
platform: Affymetrix and Illumina [~2 million] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19117981?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

replication_samplesize:
1,215 European ancestry aggressive cases, 2,213 European ancestry non-aggressive cases, 1,208 European ancestry controls, 1,034 aggressive cases, 921 non-aggressive cases, 2,231 controls


dbdate: 2009-01-14
author: Wang Y
date: 2008-12-29
journal: Proc Natl Acad Sci U S A
trait: Blood pressure
initial_samplesize: 542 Old Order Amish individuals
replication_samplesize: 5,229 European ancestry individuals, 1,347 Amish individuals, 575 Hutterite individuals
region: 2q24.3
chrom: 2
reported_genes: STK39
mapped_gene: STK39
snp_gene_ids: 27347
strongest_risk_snp: rs6749447
strongest_risk_allele: G
snps: rs6749447
snp_id_current: 6749447
context: intron
pvalue_mlog: 6.698970004336019
ci_95: [1.2-2.6] mm Hg increase in DBP
platform: Affymetrix [79,447]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19114657?ordinalpos=13&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
From the Cover: Whole-genome association study identifies STK39 as a hypertension susceptibility gene.


dbdate: 2009-01-14
author: Meisinger C
date: 2008-12-24
journal: Am J Hum Genet
study: A genome-wide association study identifies three loci associated with mean platelet volume.
trait: Mean platelet volume
initial_samplesize: 1,606 European ancestry individuals
replication_samplesize: 8,617 European ancestry individuals
region: 3p14.3
chrom: 3
reported_genes: ARHGEF3
mapped_gene: ARHGEF3
snp_gene_ids: 50650
strongest_risk_snp: rs12485738
strongest_risk_allele: A
snps: rs12485738
snp_id_current: 12485738
context: intron
pvalue_mlog: 26.39794000867203
ci_95: [0.01-0.02] per log fl increase
platform: Affymetrix [335,152]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19110211?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-02-04
author: Muglia P
date: 2008-12-23
journal: Mol Psychiatry
trait: Major depressive disorder
initial_samplesize: 1,359 European ancestry cases, 1,782 European ancestry controls
region: 12p13.32
chrom: 12
reported_genes: CCND2
mapped_gene: OTUD4P1 - HSPA8P5
upstream_gene_id: 360227
downstream_gene_id: 399988
strongest_risk_snp: rs4238010
strongest_risk_allele: G
snps: rs4238010
snp_id_current: 4238010
context: Intergenic
pvalue_mlog: 5.221848749616356
platform: Illumina and Affymetrix [494,678] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19107115?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association study of recurrent major depressive disorder in two European case-control cohorts.


dbdate: 2009-06-22
author: Pare G
date: 2008-12-19
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/19096518
trait: Glycated hemoglobin levels
initial_samplesize: 14,618 European ancestry women
replication_samplesize: 455 European ancestry individuals
region: 10q22.1
chrom: 10
reported_genes: HK1
mapped_gene: HK1
snp_gene_ids: 3098
strongest_risk_snp: rs7072268
strongest_risk_allele: A
snps: rs7072268
snp_id_current: 7072268
context: intron
pvalue_mlog: 24.69897000433602
ci_95: [NR] % increase
platform: Illumina [337,343]
cnv: N
study:
Novel association of HK1 with glycated hemoglobin in a non-diabetic population: a genome-wide evaluation of 14,618 participants in the Women's Genome Health Study.


dbdate: 2009-01-14
author: Benyamin B
date: 2008-12-17
journal: Am J Hum Genet
study: Variants in TF and HFE explain approximately 40% of genetic variation in serum-transferrin levels.
trait: Iron status biomarkers
initial_samplesize: 411 European ancestry individuals from 150 families
region: 3q22.1
chrom: 3
reported_genes: TF
mapped_gene: SRPRB
snp_gene_ids: 58477
strongest_risk_snp: rs1830084
strongest_risk_allele: A
snps: rs1830084
snp_id_current: 1830084
context: intron
pvalue_mlog: 8.999999999999998
ci_95: [NR] s.d. increase
platform: Affymetrix [100,846]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19084217?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-01-14
author: Pollin TI
date: 2008-12-17
journal: Science
trait: Triglycerides
initial_samplesize: 809 Old Order Amish individuals
replication_samplesize: 698 Old Order Amish individuals
region: 11q23.3
chrom: 11
reported_genes: APOA1, APOC3, APOA4, APOA5, DSCAML1
mapped_gene: DSCAML1
snp_gene_ids: 57453
strongest_risk_snp: rs10892151
strongest_risk_allele: A
snps: rs10892151
snp_id_current: 10892151
context: intron
pvalue_mlog: 28.52287874528033
platform: Affymetrix [381,934]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19074352?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection.


dbdate: 2009-01-16
author: Styrkarsdottir U
date: 2008-12-14
journal: Nat Genet
study: New sequence variants associated with bone mineral density.
trait: Bone mineral density (hip)
initial_samplesize: 6,865 European ancestry individuals
replication_samplesize: 8,510 European ancestry individuals
region: 1p36.12
chrom: 1
reported_genes: Intergenic
mapped_gene: MIR4418 - ZBTB40
upstream_gene_id: 100616433
downstream_gene_id: 9923
strongest_risk_snp: rs7524102
strongest_risk_allele: A
snps: rs7524102
snp_id_current: 7524102
context: Intergenic
pvalue_mlog: 16
ci_95: [0.11-0.18] s.d. decrease
platform: Illumina [305,051]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19079262?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-01-15
author: Thorleifsson G
date: 2008-12-14
journal: Nat Genet
trait: Body mass index
initial_samplesize: 72,598 European ancestry individuals, 1,160 African American individuals
replication_samplesize: Up to 11,036 European ancestry individuals, 32,615 individuals
region: 1p31.1
chrom: 1
reported_genes: NEGR1
mapped_gene: GDI2P2 - RPL31P12
upstream_gene_id: 100420259
downstream_gene_id: 100270887
strongest_risk_snp: rs2568958
strongest_risk_allele: A
snps: rs2568958
snp_id_current: 2568958
context: Intergenic
pvalue_mlog: 11
ci_95: [2.67-4.87] % SD
platform: Illumina [305,846]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19079260?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association yields new sequence variants at seven loci that associate with measures of obesity.


dbdate: 2009-01-12
author: Willer CJ
date: 2008-12-14
journal: Nat Genet
trait: Body mass index
initial_samplesize: 32,387 European ancestry individuals
replication_samplesize: 59,082 European ancestry individuals
region: 16q12.2
chrom: 16
reported_genes: FTO
mapped_gene: FTO
snp_gene_ids: 79068
strongest_risk_snp: rs9939609
strongest_risk_allele: A
snps: rs9939609
snp_id_current: 9939609
context: intron
pvalue_mlog: 50.39794000867204
ci_95: [0.27-0.39] kg/m2 increase
platform: Illumina and Affymetrix[2,399,588](imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19079261?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Six new loci associated with body mass index highlight a neuronal influence on body weight regulation.


dbdate: 2009-02-05
author: Mead S
date: 2008-12-11
journal: Lancet Neurol
study: Genetic risk factors for variant Creutzfeldt-Jakob disease: a genome-wide association study.
trait: Creutzfeldt-Jakob disease
initial_samplesize: 117 European ancestry cases, 3,083 European ancestry controls
region: 20p13
chrom: 20
reported_genes: PRNP
mapped_gene: PRNP
snp_gene_ids: 5621
strongest_risk_snp: rs1799990
strongest_risk_allele: A
snps: rs1799990
snp_id_current: 1799990
context: missense
pvalue_mlog: 20.69897000433602
platform: Affymetrix [288,908]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19081515?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

replication_samplesize:
2 European ancestry vCJD cases, 506 Oceania ancestry sCJD cases, 28 Oceania ancestry iCJD cases, 151 Oceania ancestry Kuru cases, 125 Oceania ancestry Kuru resistant cases, 3,608 European ancestry controls, 562 Oceania ancestry controls


dbdate: 2009-01-12
author: Aulchenko YS
date: 2008-12-07
journal: Nat Genet
study: Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
trait: Cholesterol, total
initial_samplesize: 21,848 European ancestry individuals, 714 Orcadian individuals
region: 1p36.11
chrom: 1
reported_genes: TMEM57
mapped_gene: TMEM57
snp_gene_ids: 55219
strongest_risk_snp: rs10903129
strongest_risk_allele: G
snps: rs10903129
snp_id_current: 10903129
context: intron
pvalue_mlog: 9.301029995663981
ci_95: [NR] s.d. increase
platform: Illumina and Affymetrix [up to ~600,000]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19060911?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-01-07
author: Bouatia-Naji N
date: 2008-12-07
journal: Nat Genet
trait: Fasting plasma glucose
initial_samplesize: 2,151 European ancestry individuals
replication_samplesize: 16,094 European ancestry individuals
region: 11q14.3
chrom: 11
reported_genes: MTNR1B
mapped_gene: RPS3AP42 - MTNR1B
upstream_gene_id: 100271597
downstream_gene_id: 4544
strongest_risk_snp: rs1387153
strongest_risk_allele: T
snps: rs1387153
snp_id_current: 1387153
context: Intergenic
pvalue_mlog: 35.69897000433601
ci_95: [0.05-0.08] mmol/l increase
platform: Illumina [308,846]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19060909?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
A variant near MTNR1B is associated with increased fasting plasma glucose levels and type 2 diabetes risk.


dbdate: 2009-01-12
author: Kathiresan S
date: 2008-12-07
journal: Nat Genet
study: Common variants at 30 loci contribute to polygenic dyslipidemia.
trait: HDL cholesterol
initial_samplesize: 19,840 European ancestry individuals
replication_samplesize: Up to 20,623 European ancestry individuals
region: 11q12.2
chrom: 11
reported_genes: FADS1, FADS2, FADS3
mapped_gene: FADS1
snp_gene_ids: 3992
strongest_risk_snp: rs174547
strongest_risk_allele: C
snps: rs174547
snp_id_current: 174547
context: intron
pvalue_mlog: 11.69897000433602
ci_95: [0.05-0.13] s.d. decrease
platform: Affymetrix and Illumina [~2,600,000] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19060906?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-01-12
author: Sabatti C
date: 2008-12-07
journal: Nat Genet
study: Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.
trait: HDL cholesterol
initial_samplesize: 4,763 Northern Finnish individuals
region: 11p11.2
chrom: 11
reported_genes: NR1H3
mapped_gene: NR1H3
snp_gene_ids: 10062
strongest_risk_snp: rs7120118
strongest_risk_allele: G
snps: rs7120118
snp_id_current: 7120118
context: intron
pvalue_mlog: 7.397940008672037
ci_95: [0.03-0.05] mmol/l increase
platform: Illumina [329,091]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19060910?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-05-07
author: Lasky-Su J
date: 2008-12-05
journal: Am J Med Genet B Neuropsychiatr Genet
trait: Attention deficit hyperactivity disorder
initial_samplesize: 930 European ancestry trios
region: 1q41
chrom: 1
reported_genes: Intergenic
mapped_gene: TGFB2 - LYPLAL1
upstream_gene_id: 7042
downstream_gene_id: 127018
strongest_risk_snp: rs1018040
snps: rs1018040
snp_id_current: 1018040
context: Intergenic
pvalue_mlog: 5.301029995663981
platform: Perlegen [429,981]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/18821565?ordinalpos=8&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association scan of quantitative traits for attention deficit hyperactivity disorder identifies novel associations and confirms candidate gene associations.


dbdate: 2009-05-07
author: Lasky-Su J
date: 2008-12-05
journal: Am J Med Genet B Neuropsychiatr Genet
study: Genome-wide association scan of the time to onset of attention deficit hyperactivity disorder.
trait: Attention deficit hyperactivity disorder (time to onset)
initial_samplesize: 930 European ancestry trios
region: 2q36.3
chrom: 2
reported_genes: Intergenic
mapped_gene: MIR4439 - NYAP2
upstream_gene_id: 100616207
downstream_gene_id: 57624
strongest_risk_snp: rs1517484
strongest_risk_allele: C
snps: rs1517484
snp_id_current: 1517484
context: Intergenic
pvalue_mlog: 6.30102999566398
platform: Perlegen [429,981]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/18937294?ordinalpos=5&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-01-15
author: Timpson NJ
date: 2008-12-03
journal: Diabetes
trait: Type 2 diabetes
replication_samplesize: Up to 3,757 European ancestry cases, up to 5,346 European ancestry controls
region: 16q12.2
chrom: 16
reported_genes: FTO
mapped_gene: FTO
snp_gene_ids: 79068
strongest_risk_snp: rs8050136
snps: rs8050136
snp_id_current: 8050136
context: intron
pvalue_mlog: 16.69897000433602
ci_95: [1.23-1.39]
platform: Affymetrix [393,453]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19056611?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data.

initial_samplesize:
958 European ancestry obese cases, 955 European ancestry non-obese cases, 2,938 European ancestry controls


dbdate: 2009-02-26
author: Prokopenko I
date: 2008-12-01
journal: Nat Genet
study: Variants in MTNR1B influence fasting glucose levels.
trait: Fasting plasma glucose
initial_samplesize: 35,812 European ancestry individuals
region: 11q14.3
chrom: 11
reported_genes: MTNR1B
mapped_gene: MTNR1B
snp_gene_ids: 4544
strongest_risk_snp: rs10830963
strongest_risk_allele: G
snps: rs10830963
snp_id_current: 10830963
context: intron
pvalue_mlog: 49.52287874528033
ci_95: [0.06-0.08] mmol/l increase
platform: Affymetrix, Illumina and Perlegen [up to 2,557,249] (imputed)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19060907?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2008-12-09
author: Terracciano A
date: 2008-11-24
journal: Mol Psychiatry
study: Genome-wide association scan for five major dimensions of personality.
trait: Personality dimensions
initial_samplesize: 3,972 Sardinian individuals
replication_samplesize: 3,903 Other ancestry individuals
region: 19q13.31
chrom: 19
reported_genes: ZNF180
mapped_gene: ZNF285B
snp_gene_ids: 147711
strongest_risk_snp: rs644148
strongest_risk_allele: G
snps: rs644148
snp_id_current: 644148
pvalue_mlog: 5.096910013008055
ci_95: [NR] s.d. increase
platform: Affymetrix[362,129]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/18957941?ordinalpos=3&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2009-01-06
author: Potkin SG
date: 2008-11-20
journal: Schizophr Bull
trait: Brain imaging in schizophrenia (interaction)
initial_samplesize: 46 European ancestry cases, 60 European ancestry controls, 18 cases, 14 controls
region: 3p12.3
chrom: 3
reported_genes: ROBO2, ROBO1
mapped_gene: VDAC1P7 - MRPS17P3
upstream_gene_id: 100310839
downstream_gene_id: 359757
strongest_risk_snp: rs9836484
snps: rs9836484
snp_id_current: 9836484
context: Intergenic
pvalue_mlog: 5.397940008672037
platform: Illumina [302,783]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19023125?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
A genome-wide association study of schizophrenia using brain activation as a quantitative phenotype.


dbdate: 2008-12-01
author: Houlston RS
date: 2008-11-16
journal: Nat Genet
trait: Colorectal cancer
initial_samplesize: 1,902 European ancestry cases, 1,929 European ancestry controls
replication_samplesize: 18,284 European ancestry cases, 18,926 European ancestry controls
region: 19q13.11
chrom: 19
reported_genes: RHPN2
mapped_gene: RHPN2
snp_gene_ids: 85415
strongest_risk_snp: rs10411210
strongest_risk_allele: C
snps: rs10411210
snp_id_current: 10411210
context: intron
pvalue_mlog: 8.301029995663981
ci_95: [1.10-1.20]
platform: Illumina[up to 548,586]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19011631?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Meta-analysis of genome-wide association data identifies four new susceptibility loci for colorectal cancer.


dbdate: 2009-01-16
author: Baranzini SE
date: 2008-11-14
journal: Hum Mol Genet
study: Genome-wide association analysis of susceptibility and clinical phenotype in multiple sclerosis.
trait: Brain lesion load
initial_samplesize: 791 European ancestry cases, 883 European ancestry controls
region: 2q37.1
chrom: 2
reported_genes: CHRND
mapped_gene: UGT1A
snp_gene_ids: 7361
strongest_risk_snp: rs2602397
snps: rs2602397
snp_id_current: 1597944
pvalue_mlog: 5.397940008672037
platform: Illumina[551,642]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/19010793?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2008-12-09
author: Aulchenko YS
date: 2008-11-09
journal: Nat Genet
study: Genetic variation in the KIF1B locus influences susceptibility to multiple sclerosis.
trait: Multiple sclerosis
initial_samplesize: 45 Dutch cases,195 Dutch controls
region: 1p36.22
chrom: 1
reported_genes: KIF1B
mapped_gene: KIF1B
snp_gene_ids: 23095
strongest_risk_snp: rs10492972
strongest_risk_allele: C
snps: rs10492972
snp_id_current: 10492972
context: intron
pvalue_mlog: 9.522878745280336
ci_95: [1.23-1.48]
platform: Affymetrix[~250,000]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/18997785?ordinalpos=&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.SmartSearch&log$=citationsensor

replication_samplesize:
1,316 European ancestry cases, 1,423 European ancestry controls, 1,318 Other ancestry cases and 1,507 Other ancestry controls from 756 families


dbdate: 2008-12-09
author: Pankratz N
date: 2008-11-06
journal: Hum Genet
study: Genomewide association study for susceptibility genes contributing to familial Parkinson disease.
trait: Parkinson's disease (familial)
initial_samplesize: 1,119 European ancestry cases, 1,127 European ancestry controls
region: 4p16.3
chrom: 4
reported_genes: GAK, DGKQ
mapped_gene: GAK
snp_gene_ids: 2580
strongest_risk_snp: rs1564282
strongest_risk_allele: T
snps: rs1564282
snp_id_current: 1564282
context: intron
pvalue_mlog: 6.154901959985743
ci_95: [NR]
platform: Illumina[328,189]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/18985386?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2008-12-09
author: Cronin S
date: 2008-11-05
journal: Eur J Hum Genet
study: Screening for replication of genome-wide SNP associations in sporadic ALS.
trait: Amyotrophic lateral sclerosis
initial_samplesize: 958 European ancestry cases, 932 European ancestry controls
replication_samplesize: 309 European ancestry cases, 404 European ancestry controls
region: 7q36.2
chrom: 7
reported_genes: DPP6
mapped_gene: DPP6
snp_gene_ids: 1804
strongest_risk_snp: rs10260404
strongest_risk_allele: C
snps: rs10260404
snp_id_current: 10260404
context: intron
pvalue_mlog: 5.522878745280337
ci_95: [1.20-1.56]
platform: Illumina[287,522]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/18987618?ordinalpos=6&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSu


dbdate: 2008-11-25
author: Cooper JD
date: 2008-11-02
journal: Nat Genet
trait: Type 1 diabetes
initial_samplesize: 3,561 European ancestry cases, 4,646 European ancestry controls
region: 2p23.3
chrom: 2
reported_genes: Intergenic
mapped_gene: RPL36AP13 - NCOA1
upstream_gene_id: 100271323
downstream_gene_id: 8648
strongest_risk_snp: rs2165738
strongest_risk_allele: C
snps: rs2165738
snp_id_current: 2165738
context: Intergenic
pvalue_mlog: 5.397940008672037
ci_95: [1.01-1.13]
platform: Affymetrix[up to 335,565]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/18978792?ordinalpos=4&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Meta-analysis of genome-wide association study data identifies additional type 1 diabetes risk loci.

replication_samplesize:
6,225 European ancestry cases, 6,946 European ancestry controls, 3,064 European ancestry trios from 2,828 families


dbdate: 2008-12-09
author: McKay JD
date: 2008-11-02
journal: Nat Genet
study: Lung cancer susceptibility locus at 5p15.33.
trait: Lung cancer
initial_samplesize: 2,971 European ancestry cases, 3,746 European ancestry controls
replication_samplesize: 2,899 European ancestry cases, 5,573 European ancestry controls
region: 5p15.33
chrom: 5
reported_genes: TERT, CLPTM1L
mapped_gene: CLPTM1L
snp_gene_ids: 81037
strongest_risk_snp: rs402710
strongest_risk_allele: C
snps: rs402710
snp_id_current: 402710
context: intron
pvalue_mlog: 5.397940008672037
ci_95: [1.12-1.24]
platform: Illumina[315,194]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/18978790?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2008-11-25
author: Wang Y
date: 2008-11-02
journal: Nat Genet
study: Common 5p15.33 and 6p21.33 variants influence lung cancer risk.
trait: Lung cancer
initial_samplesize: 5,095 European ancestry cases, 5,200 European ancestry cases
replication_samplesize: 2,448 European ancestry cases, 2,983 European ancestry controls
region: 6p21.33
chrom: 6
reported_genes: BAT3,MSH5
mapped_gene: BAG6;APOM
snp_gene_ids: 7917;55937
strongest_risk_snp: rs3117582
strongest_risk_allele: C
snps: rs3117582
snp_id_current: 3117582
context: intron;intron
pvalue_mlog: 9.301029995663981
ci_95: [1.16-1.33]
platform: Illumina[223,891]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/18978787?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2008-12-09
author: Bertram L
date: 2008-10-29
journal: Am J Hum Genet
trait: Alzheimer's disease
initial_samplesize: 941 European ancestry cases and 404 European ancestry controls from 410 families
replication_samplesize: 1,767 European ancestry cases and 838 European ancestry controls from 875 families
region: 14q31.2
chrom: 14
reported_genes: Intergenic
mapped_gene: RNU7-51P - RNU3P3
upstream_gene_id: 100151647
downstream_gene_id: 26843
strongest_risk_snp: rs11159647
snps: rs11159647
snp_id_current: 11159647
context: Intergenic
pvalue_mlog: 5.698970004336018
platform: Affymetrix[484,522]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/18976728?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Genome-wide association analysis reveals putative Alzheimer's disease susceptibility loci in addition to APOE.


dbdate: 2008-12-09
author: Anney RJ
date: 2008-10-24
journal: Am J Med Genet B Neuropsychiatr Genet
trait: Attention deficit hyperactivity disorder and conduct disorder
initial_samplesize: 938 European ancestry trios
region: 1p35.2
chrom: 1
reported_genes: Intergenic
mapped_gene: PTPRU - MATN1
upstream_gene_id: 10076
downstream_gene_id: 4146
strongest_risk_snp: rs2180233
strongest_risk_allele: C
snps: rs2180233
snp_id_current: 2180233
context: Intergenic
pvalue_mlog: 5.045757490560675
platform: Perlegen[378,332]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/18951430?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Conduct disorder and ADHD: evaluation of conduct problems as a categorical and quantitative trait in the international multicentre ADHD genetics study.


dbdate: 2008-12-01
author: Johansson A
date: 2008-10-24
journal: Hum Mol Genet
trait: Height
initial_samplesize: 3,009 European ancestry individuals, 916 Dutch individuals
replication_samplesize: Up to 39,859 European ancestry individuals, Up to 1,148 African American individuals
region: 7p15.1
chrom: 7
reported_genes: JAZF1
mapped_gene: JAZF1
snp_gene_ids: 221895
strongest_risk_snp: rs1635852
strongest_risk_allele: A
snps: rs1635852
snp_id_current: 1635852
context: intron
pvalue_mlog: 9.045757490560675
ci_95: [0.17-0.33] cm taller
platform: Illumina[NR]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/18952825?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Common variants in the JAZF1 gene associated with height identified by linkage and genome-wide association analysis.


dbdate: 2008-12-09
author: Comabella M
date: 2008-10-22
journal: PLoS One
trait: Multiple sclerosis
initial_samplesize: 242 European ancestry cases, 242 European ancestry controls
replication_samplesize: 553 European ancestry cases, 1,033 European ancestry controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DRB1
mapped_gene: C6orf10
snp_gene_ids: 10665
strongest_risk_snp: rs3129934
strongest_risk_allele: T
snps: rs3129934
snp_id_current: 3129934
context: intron
pvalue_mlog: 10.04575749056067
ci_95: [2.3-4.9]
platform: Affymetrix[428,867](pooled)
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/18941528?ordinalpos=2&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Identification of a novel risk locus for multiple sclerosis at 13q31.3 by a pooled genome-wide scan of 500,000 single nucleotide polymorphisms.


dbdate: 2008-11-25
author: Hillmer AM
date: 2008-10-12
journal: Nat Genet
study: Susceptibility variants for male-pattern baldness on chromosome 20p11.
trait: Male-pattern baldness
initial_samplesize: 296 European ancestry cases, 347 European ancestry controls
replication_samplesize: 319 European ancestry cases, 234 European ancestry controls
region: 20p11.22
chrom: 20
reported_genes: PAX1, BQ013595, BE789145
mapped_gene: RPL41P1 - LINC00261
upstream_gene_id: 22971
downstream_gene_id: 140828
strongest_risk_snp: rs2180439
strongest_risk_allele: C
snps: rs2180439
snp_id_current: 2180439
context: Intergenic
pvalue_mlog: 14.52287874528034
ci_95: [1.45-2.30]
platform: Illumina[531,695]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/18849994?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2008-11-25
author: Richards JB
date: 2008-10-12
journal: Nat Genet
study: Male-pattern baldness susceptibility locus at 20p11.
trait: Male-pattern baldness
initial_samplesize: 578 European ancestry cases, 547 European ancestry controls
replication_samplesize: 1,351 European ancestry cases, 2,485 European ancestry controls
region: 20p11.22
chrom: 20
reported_genes: PAX1
mapped_gene: LOC100270679
snp_gene_ids: 100270679
strongest_risk_snp: rs1160312
strongest_risk_allele: A
snps: rs1160312
snp_id_current: 1160312
context: intron
pvalue_mlog: 14
ci_95: [1.42-1.80] (males)
platform: Affymetrix[370,102]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/18849991?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum


dbdate: 2008-11-25
author: Stacey SN
date: 2008-10-12
journal: Nat Genet
trait: Basal cell carcinoma
initial_samplesize: 930 European ancestry cases, 33,117 European ancestry controls
replication_samplesize: 1,216 European ancestry cases, 2,844 European ancestry controls
region: 1p36.13
chrom: 1
reported_genes: PADI4, PADI6,RCC2, ARHGEF10L
mapped_gene: PADI6
snp_gene_ids: 353238
strongest_risk_snp: rs7538876
strongest_risk_allele: A
snps: rs7538876
snp_id_current: 7538876
context: intron
pvalue_mlog: 11.39794000867204
ci_95: [1.19-1.37]
platform: Illumina[304,083]
cnv: N
link:
http://www.ncbi.nlm.nih.gov/pubmed/18849993?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_DefaultReportPanel.Pubmed_RVDocSum

study:
Common variants on 1p36 and 1q42 are associated with cutaneous basal cell carcinoma but not with melanoma or pigmentation traits.


