# gwascat

dbdate: 2014-08-02
author: Ferreira MA
date: 2013-12-30
journal: J Allergy Clin Immunol
link: http://www.ncbi.nlm.nih.gov/pubmed/24388013
trait: Asthma and hay fever
initial_samplesize: 6,685 European ancestry cases, 14,091 European ancestry controls
replication_samplesize: 878 European ancestry cases, 2,455 European ancestry controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DQB1
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs9273373
strongest_risk_allele: G
snps: rs9273373
snp_id_current: 9273373
pvalue_mlog: 13.39794000867204
ci_95: [1.17-1.30]
platform: Illumina [up to 4,972,397] (imputed)
cnv: N
study:
Genome-wide association analysis identifies 11 risk variants associated with the asthma with hay fever phenotype.


dbdate: 2014-08-02
author: Zhou L
date: 2013-12-30
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/24386095
trait: Lipid traits
initial_samplesize: 3,451 Han Chinese ancestry individuals
replication_samplesize: 8,830 Han Chinese ancestry individuals
region: 1p31.3
chrom: 1
reported_genes: DOCK7
mapped_gene: DOCK7
snp_gene_ids: 85440
strongest_risk_snp: rs11207995
strongest_risk_allele: C
snps: rs11207995
snp_id_current: 11207995
context: intron
pvalue_mlog: 9.221848749616356
ci_95: [0.00024-0.02376] mmol/L decrease
platform: Illumina and Affymetrix [up to 2,249,917] (imputed)
cnv: N
study:
A genome wide association study identifies common variants associated with lipid levels in the Chinese population.


dbdate: 2014-08-05
author: Okada Y
date: 2013-12-25
journal: Nature
link: http://www.ncbi.nlm.nih.gov/pubmed/24390342
study: Genetics of rheumatoid arthritis contributes to biology and drug discovery.
trait: Rheumatoid arthritis
region: 2q13
chrom: 2
reported_genes: ACOXL
mapped_gene: ACOXL
snp_gene_ids: 55289
strongest_risk_snp: rs6732565
strongest_risk_allele: A
snps: rs6732565
snp_id_current: 6732565
context: intron
pvalue_mlog: 8.045757490560675
ci_95: [1.07-1.14]
platform: Affymetrix & Illumina [up to 9,739,303] (Imputed)
cnv: N
initial_samplesize:
up to 14,361 European ancestry cases, up to 42,923 European ancestry controls, up to 4,873 East Asian ancestry cases, up to 17,642 East Asian ancestry controls

replication_samplesize:
up to 3,775 European ancestry cases, up to 5,801 European ancestry controls, up to 6,871 East Asian ancestry cases, up to 6,392 East Asian ancestry controls


dbdate: 2014-08-02
author: Williams AL
date: 2013-12-25
journal: Nature
link: http://www.ncbi.nlm.nih.gov/pubmed/24390345
study: Sequence variants in SLC16A11 are a common risk factor for type 2 diabetes in Mexico.
trait: Type 2 diabetes
region: 17p13.1
chrom: 17
reported_genes: SLC16A11, SLC16A13
mapped_gene: SLC16A11
snp_gene_ids: 162515
strongest_risk_snp: rs75493593
snps: rs75493593
snp_id_current: 75493593
context: missense
pvalue_mlog: 14.30102999566398
ci_95: [1.18-1.32]
platform: Illumina [9.2 million] (Imputed)
cnv: N
initial_samplesize:
3,848 Mexican and other Latin American ancestry cases, 4,366 Mexican and other Latin American ancestry controls

replication_samplesize:
896 Mexican American cases, 832 Mexican American controls, 2,768 East Asian ancestry cases, 2,880 East Asian ancestry controls, 1,082 South Asian ancestry cases, 1,105 South Asian ancestry controls, 1,874 European ancestry cases, 1,333 European ancestry controls, 2,127 African American cases, 2,103 African American controls, 698 Native Hawaiian ancestry cases, 579 Native Hawaiian ancestry controls, 2,009 Singaporean cases, 1959 Singaporean controls


dbdate: 2014-08-01
author: Miki D
date: 2013-12-20
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/24376798
trait: Chronic hepatitis C infection
initial_samplesize: 481 Japanese ancestry cases, 2,963 Japanese ancestry controls
replication_samplesize: 5,737 Japanese ancestry cases, 26,931 Japanese ancestry controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DQB1, HLA-DQA1
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs9275572
strongest_risk_allele: T
snps: rs9275572
snp_id_current: 9275572
pvalue_mlog: 15.39794000867204
ci_95: [1.19-1.33]
platform: Illumina [458,207]
cnv: N
study:
HLA-DQB1*03 confers susceptibility to chronic hepatitis C in Japanese: a genome-wide association study.


dbdate: 2014-08-03
author: Rocanin-Arjo A
date: 2013-12-19
journal: Blood
link: http://www.ncbi.nlm.nih.gov/pubmed/24357727
trait: Thrombin generation potential phenotypes
initial_samplesize: 714 European ancestry venous thrombosis cases, 1,253 European ancestry individuals
replication_samplesize: 714 European ancestry venous thrombosis cases, 543 European ancestry individuals
region: 9q32
chrom: 9
reported_genes: ORM1
mapped_gene: ORM1
snp_gene_ids: 5004
strongest_risk_snp: rs150611042
strongest_risk_allele: A
snps: rs150611042
snp_id_current: 150611042
context: nearGene-5
pvalue_mlog: 14.15490195998574
ci_95: [0.27-0.44] min decrease
platform: NR [6,652,054] (Imputed)
cnv: N
study:
A meta-analysis of genome-wide association studies identifies ORM1 as a novel gene controlling thrombin generation potential.


dbdate: 2014-08-05
author: Nanayakkara S
date: 2013-12-18
journal: J Occup Health
link: http://www.ncbi.nlm.nih.gov/pubmed/24351856
trait: Chronic kidney disease
initial_samplesize: 301 Sinhalese Sri Lankan ancestry cases, 276 Sinhalese Sri Lankan ancestry controls
region: 20q13.12
chrom: 20
reported_genes: SLC13A3
mapped_gene: SLC13A3
snp_gene_ids: 64849
strongest_risk_snp: rs6066043
strongest_risk_allele: G
snps: rs6066043
snp_id_current: 6066043
context: intron
pvalue_mlog: 8.698970004336019
ci_95: [NR]
platform: Illumina [543,848]
cnv: N
study:
An integrative study of the genetic, social and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka.


dbdate: 2014-08-02
author: Shaffer JR
date: 2013-12-17
journal: G3 (Bethesda)
link: http://www.ncbi.nlm.nih.gov/pubmed/24347629
trait: Periodontal disease-related phenotypes
initial_samplesize: 93 European ancestry cases, 83 European ancestry individuals, 497 European ancestry controls
region: 18q12.1
chrom: 18
reported_genes: CDH2
mapped_gene: CDH2 - ARIH2P1
upstream_gene_id: 1000
downstream_gene_id: 390844
strongest_risk_snp: rs11659841
snps: rs11659841
snp_id_current: 11659841
context: Intergenic
pvalue_mlog: 5.045757490560675
ci_95: [NR]
platform: Illumina [~1.4 million] (Imputed)
cnv: N
study:
Genome-wide association study of periodontal health measured by probing depth in adults ages 18-49 years.


dbdate: 2014-07-30
author: Voruganti VS
date: 2013-12-16
journal: Front Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24379826
trait: Serum uric acid levels
initial_samplesize: 632 Mexican American individuals
region: 4p16.1
chrom: 4
reported_genes: SLC2A9
mapped_gene: SLC2A9
snp_gene_ids: 56606
strongest_risk_snp: rs6832439
strongest_risk_allele: A
snps: rs6832439
snp_id_current: 6832439
context: intron
pvalue_mlog: 7.522878745280337
platform: Illumina [NR] (imputed)
cnv: N
study:
Genome-wide association analysis confirms and extends the association of SLC2A9 with serum uric acid levels to Mexican Americans.


dbdate: 2014-07-29
author: Simino J
date: 2013-12-12
journal: Front Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24376456
trait: Diastolic blood pressure (alcohol consumption interaction)
initial_samplesize: up to 6,882 European ancestry individuals
region: 2p23.2
chrom: 2
reported_genes: FAM179A
mapped_gene: FAM179A
snp_gene_ids: 165186
strongest_risk_snp: rs13008299
strongest_risk_allele: G
snps: rs13008299
snp_id_current: 13008299
context: intron
pvalue_mlog: 7.154901959985742
ci_95: [0.033-0.103] unit decrease
platform: Affymetrix [2.5 million] (Imputed)
cnv: N
study:
Gene-alcohol interactions identify several novel blood pressure loci including a promising locus near SLC16A9.


dbdate: 2014-07-28
author: Winham SJ
date: 2013-12-10
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/24322204
trait: Bipolar disorder (body mass index interaction)
initial_samplesize: 388 European ancestry cases, 1,020 European ancestry controls
region: 15q26.1
chrom: 15
reported_genes: SEPHS1P2, MCTP2
mapped_gene: UNQ9370 - SEPHS1P2
upstream_gene_id: 400454
downstream_gene_id: 100420292
strongest_risk_snp: rs17541406
snps: rs17541406
snp_id_current: 17541406
context: Intergenic
pvalue_mlog: 5.999999999999999
platform: NR [up to 8,466,825] (imputed)
cnv: N
study:
Genome-wide association study of bipolar disorder accounting for effect of body mass index identifies a new risk allele in TCF7L2.


dbdate: 2014-07-29
author: Purrington KS
date: 2013-12-09
journal: Carcinogenesis
link: http://www.ncbi.nlm.nih.gov/pubmed/24325915
initial_samplesize: 1,529 European ancestry cases, 3,399 European ancestry controls
replication_samplesize: 2,148 European ancestry cases, 1,309 European ancestry controls
region: 1q32.1
chrom: 1
reported_genes: MDM4
mapped_gene: MDM4
snp_gene_ids: 4194
strongest_risk_snp: rs4245739
strongest_risk_allele: C
snps: rs4245739
snp_id_current: 4245739
context: ncRNA
pvalue_mlog: 5.397940008672037
ci_95: [1.11-1.29]
platform: Illumina [NR] (imputed)
cnv: N
study:
Genome-wide association study identifies 25 known breast cancer susceptibility loci as risk factors for triple-negative breast cancer.

trait:
Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative)


dbdate: 2014-07-29
author: van der Valk RJ
date: 2013-12-05
journal: J Allergy Clin Immunol
link: http://www.ncbi.nlm.nih.gov/pubmed/24315451
trait: Fractional exhaled nitric oxide (childhood)
initial_samplesize: 5,131 European ancestry individuals, 1,155 Hispanic individuals, 2,572 individuals
region: 17q11.2
chrom: 17
reported_genes: LYRM9
mapped_gene: LYRM9
snp_gene_ids: 201229
strongest_risk_snp: rs3751972
strongest_risk_allele: C
snps: rs3751972
snp_id_current: 3751972
context: UTR-3
pvalue_mlog: 9.698970004336017
ci_95: [0.059-0.113] unit increase
platform: Illumina & Affymetrix [2,253,077] (Imputed)
cnv: N
study:
Fraction of exhaled nitric oxide values in childhood are associated with 17q11.2-q12 and 17q12-q21 variants.


dbdate: 2014-07-29
author: An P
date: 2013-12-04
journal: Metabolism
link: http://www.ncbi.nlm.nih.gov/pubmed/24405752
trait: Glycated hemoglobin levels
initial_samplesize: 4,088 European ancestry non-diabetic elderly individuals
replication_samplesize: up to 47,822 European ancestry non-diabetic elderly individuals
region: 2q31.1
chrom: 2
reported_genes: G6PC2
mapped_gene: G6PC2
snp_gene_ids: 57818
strongest_risk_snp: rs560887
strongest_risk_allele: T
snps: rs560887
snp_id_current: 560887
context: intron
pvalue_mlog: 17
ci_95: [0.024-0.040] unit decrease
platform: Illumina [9.25 million] (Imputed)
cnv: N
study:
Genome-wide association study identifies common loci influencing circulating glycated hemoglobin (HbA1c) levels in non-diabetic subjects: the Long Life Family Study (LLFS).


dbdate: 2014-07-26
author: Yatagai Y
date: 2013-12-04
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/24324648
trait: IgE levels
initial_samplesize: 967 Japanese ancestry individuals, 213 Japanese ancestry asthmatics
replication_samplesize: 1,894 Japanese ancestry individuals, 580 Japanese ancestry asthmatics
region: 6p21.33
chrom: 6
reported_genes: HLA-C, HCG27
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs3130941
strongest_risk_allele: C
snps: rs3130941
snp_id_current: 3130941
pvalue_mlog: 10
ci_95: unit increase
platform: Illumina [479,940]
cnv: N
study:
Genome-wide association study for levels of total serum IgE identifies HLA-C in a Japanese population.


dbdate: 2014-07-29
author: Namjou B
date: 2013-12-03
journal: Front Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24348519
trait: Body mass index
initial_samplesize: up to 2,860 European ancestry children
region: 16q12.2
chrom: 16
reported_genes: FTO
mapped_gene: FTO
snp_gene_ids: 79068
strongest_risk_snp: rs8050136
strongest_risk_allele: A
snps: rs8050136
snp_id_current: 8050136
context: intron
pvalue_mlog: 7
platform: Illumina & Affymetrix [up to 583,824] (imputed)
cnv: N
study:
EMR-linked GWAS study: investigation of variation landscape of loci for body mass index in children.


dbdate: 2014-08-06
author: Domarkiene I
date: 2013-12-01
journal: Balkan J Med Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24778558
trait: Coronary heart disease
initial_samplesize: 31 European ancestry cases and 63 European ancestry controls from 32 families
region: 1q32.1
chrom: 1
reported_genes: PPP1R12B
mapped_gene: PPP1R12B
snp_gene_ids: 4660
strongest_risk_snp: rs12734338
strongest_risk_allele: G
snps: rs12734338
snp_id_current: 12734338
context: intron
pvalue_mlog: 6.522878745280337
ci_95: [3.95-212.9]
platform: Illumina [646,445]
cnv: N
study:
RTN4 and FBXL17 Genes are Associated with Coronary Heart Disease in Genome-Wide Association Analysis of Lithuanian Families.


dbdate: 2014-03-13
author: Negi S
date: 2013-12-01
journal: Arthritis Rheum
link: http://www.ncbi.nlm.nih.gov/pubmed/23918589
trait: Rheumatoid arthritis
initial_samplesize: 706 North Indian ancestry cases, 761 North Indian ancestry controls
replication_samplesize: 927 North Indian ancestry cases, 1,148 North Indian ancestry controls
region: 5q11.2
chrom: 5
reported_genes: ARL15
mapped_gene: ARL15
snp_gene_ids: 54622
strongest_risk_snp: rs255758
strongest_risk_allele: C
snps: rs255758
snp_id_current: 255758
context: intron
pvalue_mlog: 5.154901959985742
ci_95: [1.22-1.66]
platform: Illumina [559,348]
cnv: N
study:
A genome-wide association study reveals ARL15, a novel non-HLA susceptibility gene for rheumatoid arthritis in North Indians.


dbdate: 2014-06-19
author: Speedy HE
date: 2013-12-01
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24292274
trait: Chronic lymphocytic leukemia
initial_samplesize: 1,739 European ancestry cases, 5,199 European ancestry controls
replication_samplesize: 1,144 European ancestry cases, 3,151 European ancestry controls
region: 3q26.2
chrom: 3
reported_genes: MYNN
mapped_gene: MYNN
snp_gene_ids: 55892
strongest_risk_snp: rs10936599
strongest_risk_allele: C
snps: rs10936599
snp_id_current: 10936599
context: cds-synon
pvalue_mlog: 8.698970004336019
ci_95: [1.17-1.35]
platform: Illumina [450,000] (Imputed)
cnv: N
study:
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.


dbdate: 2014-06-21
author: Pan L
date: 2013-11-28
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24282030
trait: Hepatitis B vaccine response
initial_samplesize: 108 Han Chinese ancestry high-responder cases, 77 Han Chinese ancestry non-responder controls
replication_samplesize: 1,336 Han Chinese ancestry high-responder cases, 420 Han Chinese ancestry non-responder controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DRB1, BTNL2, HLA-DRA, C6orf10
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs477515
strongest_risk_allele: T
snps: rs477515
snp_id_current: 477515
pvalue_mlog: 18.52287874528033
ci_95: [1.75-2.41]
platform: Illumina [588,026]
cnv: N
study:
A genome-wide association study identifies polymorphisms in the HLA-DR region associated with non-response to hepatitis B vaccination in Chinese Han populations.


dbdate: 2014-07-25
author: Boardman JD
date: 2013-11-27
journal: Demography
link: http://www.ncbi.nlm.nih.gov/pubmed/24281739
trait: Body mass index (education interaction)
initial_samplesize: 816 non-college graduate individuals and 1,061 college graduate individuals
region: 5q23.3
chrom: 5
mapped_gene: ARL2BPP4 - RPL11P2
upstream_gene_id: 100130265
downstream_gene_id: 133629
strongest_risk_snp: rs12518350
snps: rs12518350
snp_id_current: 12518350
context: Intergenic
pvalue_mlog: 5.221848749616356
platform: Affymetrix [260,402]
cnv: N
study:
Is the gene-environment interaction paradigm relevant to genome-wide studies? The case of education and body mass index.


dbdate: 2014-06-28
author: Quillen EE
date: 2013-11-26
journal: Am J Med Genet B Neuropsychiatr Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24277619
trait: Alcohol consumption (maxi-drinks)
initial_samplesize: 272 Han Chinese ancestry individuals
region: 5p15.2
chrom: 5
mapped_gene: CTD-2154B17.1 - CTNND2
upstream_gene_id: 102723441
downstream_gene_id: 1501
strongest_risk_snp: rs6882716
snps: rs6882716
snp_id_current: 6882716
context: Intergenic
pvalue_mlog: 5.698970004336018
ci_95: unit increase
platform: Illumina [247,725]
cnv: N
study:
ALDH2 is associated to alcohol dependence and is the major genetic determinant of "daily maximum drinks" in a GWAS study of an isolated rural chinese sample.


dbdate: 2014-06-28
author: Ruderfer DM
date: 2013-11-26
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/24280982
study: Polygenic dissection of diagnosis and clinical dimensions of bipolar disorder and schizophrenia.
trait: Schizophrenia or bipolar disorder
region: 12p13.33
chrom: 12
reported_genes: CACNA1C
mapped_gene: CACNA1C
snp_gene_ids: 775
strongest_risk_snp: rs1006737
snps: rs1006737
snp_id_current: 1006737
context: intron
pvalue_mlog: 12.22184874961636
platform: Illumina and Affymetrix [~1.1 Million] (imputed)
cnv: N
initial_samplesize:
up to 2,461 European ancestry schizophrenia cases, up to 6,908 schizophrenia cases, up to 4,903 European ancestry bipolar disorder cases, up to 5,507 bipolar disorder cases, up to 7,213 European ancestry controls, up to 12,210 controls


dbdate: 2014-07-25
author: Wu AC
date: 2013-11-23
journal: J Allergy Clin Immunol
link: http://www.ncbi.nlm.nih.gov/pubmed/24280104
trait: Bronchodilator response in asthma (inhaled corticosteroid treatment interaction)
initial_samplesize: 172 European ancestry cases, 409 European ancestry controls
replication_samplesize: 227 European ancestry cases
region: 19q13.41
chrom: 19
mapped_gene: ZNF841 - ZNF616
upstream_gene_id: 284371
downstream_gene_id: 90317
strongest_risk_snp: rs10411428
strongest_risk_allele: T
snps: rs10411428
snp_id_current: 10411428
context: Intergenic
pvalue_mlog: 8.999999999999998
platform: Illumina [449,540]
cnv: N
study:
Inhaled corticosteroid treatment modulates ZNF432 gene variant's effect on bronchodilator response in asthmatics.


dbdate: 2014-07-23
author: Dichgans M
date: 2013-11-21
journal: Stroke
link: http://www.ncbi.nlm.nih.gov/pubmed/24262325
trait: Coronary artery disease
initial_samplesize: 33,398 cases, 75,726 controls
region: 9p21.3
chrom: 9
reported_genes: CDKN2BAS
mapped_gene: UBA52P6 - DMRTA1
upstream_gene_id: 100130239
downstream_gene_id: 63951
strongest_risk_snp: rs1333049
strongest_risk_allele: C
snps: rs1333049
snp_id_current: 1333049
context: Intergenic
pvalue_mlog: 55.52287874528033
ci_95: [1.21-1.28]
platform: Illumina [575,000] (imputed)
cnv: N
study:
Shared genetic susceptibility to ischemic stroke and coronary artery disease: a genome-wide analysis of common variants.


dbdate: 2014-07-23
author: Deng X
date: 2013-11-20
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/24324551
trait: Antibody status in Tripanosoma cruzi seropositivity
initial_samplesize: 580 Brazilian ancestry individuals
region: 3p14.1
chrom: 3
reported_genes: LRIG1
mapped_gene: LRIG1
snp_gene_ids: 26018
strongest_risk_snp: rs13078828
snps: rs13078828
snp_id_current: 13078828
context: intron
pvalue_mlog: 6.397940008672037
platform: Affymetrix [5,486,770] (Imputed)
cnv: N
study:
Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects.


dbdate: 2014-05-28
author: Fogh I
date: 2013-11-20
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24256812
trait: Amyotrophic lateral sclerosis (sporadic)
initial_samplesize: 6,100 European ancestry cases, 7,125 European ancestry controls
replication_samplesize: 2,074 European ancestry cases, 2,556 European ancestry controls
region: 17q11.2
chrom: 17
reported_genes: SALM1
mapped_gene: KRT18P55
snp_gene_ids: 284085
strongest_risk_snp: rs34517613
strongest_risk_allele: T
snps: rs34517613
snp_id_current: 34517613
context: intron
pvalue_mlog: 8.045757490560675
ci_95: [1.12-1.29]
platform: Illumina [~ 7 Million] (imputed)
cnv: N
study:
A genome-wide association meta-analysis identifies a novel locus at 17q11.2 associated with sporadic amyotrophic lateral sclerosis.


dbdate: 2014-07-22
author: Lencz T
date: 2013-11-19
journal: Nat Commun
link: http://www.ncbi.nlm.nih.gov/pubmed/24253340
study: Genome-wide association study implicates NDST3 in schizophrenia and bipolar disorder.
trait: Schizophrenia
initial_samplesize: 904 Ashkenzai Jewish cases, 1,640 Ashkenzai Jewish controls
region: 4q26
chrom: 4
reported_genes: NDST3
mapped_gene: NT5C3AP1 - NDST3
upstream_gene_id: 90859
downstream_gene_id: 9348
strongest_risk_snp: rs11098403
strongest_risk_allele: G
snps: rs11098403
snp_id_current: 11098403
context: Intergenic
pvalue_mlog: 7.522878745280337
ci_95: [1.08-1.21]
platform: Illumina [762,372]
cnv: N
replication_samplesize:
3,944 European ancestry cases, 3,049 European ancestry controls, 921 African American cases, 954 African American controls, 550 Japanese ancestry cases, 530 Japanese ancestry controls


dbdate: 2014-07-25
author: Bonnelykke K
date: 2013-11-17
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24241537
trait: Asthma (childhood, severe)
initial_samplesize: 1,173 European ancestry cases, 2,511 European ancestry controls
replication_samplesize: 7,178 European ancestry cases, 10,383 European ancestry controls, 63 cases, 3,605 controls
region: 7q22.3
chrom: 7
reported_genes: CDHR3
mapped_gene: CDHR3
snp_gene_ids: 222256
strongest_risk_snp: rs6967330
strongest_risk_allele: A
snps: rs6967330
snp_id_current: 6967330
context: missense
pvalue_mlog: 13.52287874528034
ci_95: [1.18-1.33]
platform: Affymetrix and Illumina [124,514]
cnv: N
study:
A genome-wide association study identifies CDHR3 as a susceptibility locus for early childhood asthma with severe exacerbations.


dbdate: 2014-07-20
author: Zhang L
date: 2013-11-17
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24249740
study: Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.
trait: Bone mineral density
region: 14q24.2
chrom: 14
reported_genes: SMOC1
mapped_gene: SMOC1
snp_gene_ids: 64093
strongest_risk_snp: rs227425
strongest_risk_allele: G
snps: rs227425
snp_id_current: 227425
context: intron
pvalue_mlog: 12.39794000867204
ci_95: [NR] unit decrease
platform: Illumina & Affymetrix [5,842,825] (Imputed)
cnv: N
initial_samplesize:
5,833 European ancestry females, 2,639 European ancestry males, 784 Han Chinese ancestry females, 763 Han Chinese ancestry males, 712 African American females, 409 Hispanic females

replication_samplesize:
7,010 European ancestry females, 3,772 European ancestry males, 2,980 East Asian ancestry females, 2,159 East Asian ancestry males


dbdate: 2014-07-22
author: Goris A
date: 2013-11-13
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24234648
trait: Multiple sclerosis or amyotrophic lateral sclerosis
initial_samplesize: 4,088 Multiple sclerosis cases, 3,762 Amyotrophic lateralsclerosis cases, 12,030 controls
region: 17q21.32
chrom: 17
reported_genes: NPEPPS
mapped_gene: NPEPPS
snp_gene_ids: 9520
strongest_risk_snp: rs2935183
snps: rs2935183
snp_id_current: 2935183
context: nearGene-5
pvalue_mlog: 6.30102999566398
platform: NR [5,440,446] (imputed)
cnv: N
study:
No evidence for shared genetic basis of common variants in multiple sclerosis and amyotrophic lateral sclerosis.


dbdate: 2014-07-22
author: Chen P
date: 2013-11-07
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/24244560
trait: Glycated hemoglobin levels
region: 7p13
chrom: 7
reported_genes: GCK
mapped_gene: GCK
snp_gene_ids: 2645
strongest_risk_snp: rs1799884
strongest_risk_allele: T
snps: rs1799884
snp_id_current: 1799884
context: nearGene-5
pvalue_mlog: 7.221848749616355
ci_95: [0.42-0.46] unit increase
platform: Illumina [up to 2.4 Million] (imputed)
cnv: N
study:
A study assessing the association of glycated hemoglobin A1C (HbA1C) associated variants with HbA1C, chronic kidney disease and diabetic retinopathy in populations of Asian ancestry.

initial_samplesize:
3,427 Chinese ancestry individuals, 1,735 Malay ancestry individuals, 1,520 Asian Indian ancestry individuals


dbdate: 2014-05-13
author: Behr ER
date: 2013-11-06
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/24223155
trait: Drug-induced torsades de pointes
region: 18q12.2
chrom: 18
reported_genes: C18orf21, RPRD1A, MIR187, GALNT1
mapped_gene: C18orf21
snp_gene_ids: 83608
strongest_risk_snp: rs2276314
snps: rs2276314
snp_id_current: 2276314
context: missense
pvalue_mlog: 6.397940008672037
ci_95: [1.5-2.6]
platform: Illumina [3,542,142] (imputed)
cnv: N
study:
Genome wide analysis of drug-induced torsades de pointes: lack of common variants with large effect sizes.

initial_samplesize:
216 European ancestry cases, 386 European ancestry drug-exposed controls, 385 European ancestry population controls


dbdate: 2014-07-23
author: Xia K
date: 2013-11-05
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/24189344
study: Common genetic variants on 1p13.2 associate with risk of autism.
trait: Autism
replication_samplesize: 1,299 cases and 2,598 controls from 1,299 European ancestry trios
region: 1p13.2
chrom: 1
reported_genes: TRIM33, BCAS2, DENND2C
mapped_gene: TRIM33;LOC101928890
snp_gene_ids: 51592;101928890
strongest_risk_snp: rs6537825
strongest_risk_allele: A
snps: rs6537825
snp_id_current: 6537825
context: missense;intron
pvalue_mlog: 7.522878745280337
ci_95: [NR]
platform: Illumina [702,234] (imputed)
cnv: N
initial_samplesize:
275 cases and 550 controls from 275 Chinese ancestry trios, 136 Chinese ancestry cases, 984 Chinese ancestry controls


dbdate: 2014-04-02
author: Rudolph A
date: 2013-11-04
journal: Endocr Relat Cancer
link: http://www.ncbi.nlm.nih.gov/pubmed/24080446
trait: Breast cancer (menopausal hormone therapy interaction)
initial_samplesize: 2,920 European ancestry cases
replication_samplesize: 7,689 European ancestry cases, 9,266 European ancestry controls
region: 13q12.3
chrom: 13
reported_genes: POMP
mapped_gene: FLT1 - EIF4A1P7
upstream_gene_id: 2321
downstream_gene_id: 341784
strongest_risk_snp: rs9579199
snps: rs9579199
snp_id_current: 9579199
context: Intergenic
pvalue_mlog: 5.096910013008055
ci_95: [1.11-1.32]
platform: Illumina [2.5 million] (Imputed)
cnv: N
study:
Genetic modifiers of menopausal hormone replacement therapy and breast cancer risk: a genome-wide interaction study.


dbdate: 2014-06-26
author: Cornejo-Garcia JA
date: 2013-11-01
journal: Pharmacogenomics
link: http://www.ncbi.nlm.nih.gov/pubmed/24236485
trait: Acute urticaria and angioedema (non-steroidal anti-inflammatory drug-induced)
region: 3q12.2
chrom: 3
reported_genes: ABI3BP
mapped_gene: ABI3BP
snp_gene_ids: 25890
strongest_risk_snp: rs9833094
strongest_risk_allele: T
snps: rs9833094
snp_id_current: 9833094
context: intron
pvalue_mlog: 6.30102999566398
ci_95: [1.88-4.64]
platform: Affymetrix [up to 644,046]
cnv: N
study:
Genome-wide association study in NSAID-induced acute urticaria/angioedema in Spanish and Han Chinese populations.

initial_samplesize:
112 European ancestry cases, 124 European ancestry controls, 120 Han Chinese ancestry cases, 101 Han Chinese ancestry controls


dbdate: 2014-04-15
author: Haga S
date: 2013-10-31
journal: J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24172245
study: A genome-wide association study of third molar agenesis in Japanese and Korean populations.
trait: Tooth agenesis (mandibular third molar)
replication_samplesize: N/A
region: 10q21.3
chrom: 10
reported_genes: Intergenic
mapped_gene: MRPL35P2 - RPL7AP50
upstream_gene_id: 359743
downstream_gene_id: 87688
strongest_risk_snp: rs938036
strongest_risk_allele: T
snps: rs938036
snp_id_current: 938036
context: Intergenic
pvalue_mlog: 5.096910013008055
ci_95: [1.81-4.59]
platform: Illumina [532,105]
cnv: N
initial_samplesize:
80 East Asian ancestry mandibular cases, 69 East Asian ancestry maxillary cases, 338 East Asian ancestry controls


dbdate: 2014-05-13
author: Han F
date: 2013-10-31
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24204295
trait: Narcolepsy
initial_samplesize: 1,189 Chinese ancestry cases, 1,997 Chinese ancestry controls
replication_samplesize: 2,693 European ancestry cases, 11,495 European ancestry controls
region: 14q11.2
chrom: 14
reported_genes: TRA
mapped_gene: TRA
snp_gene_ids: 6955
strongest_risk_snp: rs1154155
strongest_risk_allele: G
snps: rs1154155
snp_id_current: 1154155
pvalue_mlog: 48.30102999566397
ci_95: [1.53-1.75]
platform: Affymetrix [603,382]
cnv: N
study:
Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.


dbdate: 2014-05-13
author: Han F
date: 2013-10-31
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24204295
trait: Narcolepsy (onset before 2009 H1N1 influenza pandemic)
region: 6p21.32
chrom: 6
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs9270965
snps: rs9270965
snp_id_current: 9270965
pvalue_mlog: 11.30102999566398
ci_95: [NR]
platform: Affymetrix [603,382]
cnv: N
initial_samplesize:
up to 893 Chinese ancestry cases with onset before the 2009 H1N1 influenza pandemic, up to 373 Chinese ancestry cases with onset after the 2009 H1N1 influenza pandemic


dbdate: 2014-05-03
author: Sleiman P
date: 2013-10-29
journal: Sci Rep
link: http://www.ncbi.nlm.nih.gov/pubmed/24166486
study: GWAS meta analysis identifies TSNARE1 as a novel Schizophrenia / Bipolar susceptibility locus.
trait: Schizophrenia, schizoaffective disorder or bipolar disorder
replication_samplesize: 2652 individuals
region: 1q43
chrom: 1
reported_genes: SDCCAG8
mapped_gene: SDCCAG8
snp_gene_ids: 10806
strongest_risk_snp: rs6703335
snps: rs6703335
snp_id_current: 6703335
context: intron
pvalue_mlog: 8.397940008672036
platform: Illumina & Affymetrix [NR] (imputed)
cnv: N
initial_samplesize:
11,985 schizophrenia cases, 377 schizoaffective disorder cases, 1,032 bipolar disorder cases, 34,676 controls


dbdate: 2014-04-26
author: He J
date: 2013-10-28
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24165912
trait: Blood pressure measurement (cold pressor test)
initial_samplesize: 1,881 Han Chinese ancestry individuals
replication_samplesize: 698 Han Chinese ancestry individuals
region: 7q22.1
chrom: 7
reported_genes: FBXL13
mapped_gene: FBXL13
snp_gene_ids: 222235
strongest_risk_snp: rs17135875
strongest_risk_allele: C
snps: rs17135875
snp_id_current: 17135875
context: intron
pvalue_mlog: 5.999999999999999
ci_95: [1.67-3.95] mmHg decrease
platform: Affymetrix [2,216,774] (Imputed)
cnv: N
study:
Genome-wide association study identifies 8 novel loci associated with blood pressure responses to interventions in Han Chinese.


dbdate: 2014-05-13
author: Zheng JS
date: 2013-10-28
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/24204828
trait: Fasting insulin (interaction)
initial_samplesize: 820 European ancestry individuals
region: 2q34
chrom: 2
reported_genes: SPAG16
mapped_gene: SPAG16
snp_gene_ids: 79582
strongest_risk_snp: rs6707387
strongest_risk_allele: A
snps: rs6707387
snp_id_current: 6707387
context: intron
pvalue_mlog: 6.221848749616355
platform: Affymetrix [590,000]
cnv: N
study:
Genome-wide contribution of genotype by environment interaction to variation of diabetes-related traits.


dbdate: 2014-04-15
author: Hu Z
date: 2013-10-27
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24162738
study: New loci associated with chronic hepatitis B virus infection in Han Chinese.
trait: Hepatitis B
initial_samplesize: 951 Han Chinese ancestry HBV carrier cases, 937 Han Chinese ancestry HBV cleared controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DQB2
mapped_gene: HLA-DQB2
snp_gene_ids: 3120
strongest_risk_snp: rs7453920
strongest_risk_allele: G
snps: rs7453920
snp_id_current: 7453920
context: intron
pvalue_mlog: 36.30102999566397
ci_95: [1.69-2.08]
platform: Illumina [490,610]
cnv: N
replication_samplesize:
4,230 Chinese ancestry HBV carrier cases, 3,051 Chinese ancestry HBV cleared controls, 2,622 Chinese ancestry controls


dbdate: 2014-05-02
author: Seppala I
date: 2013-10-24
journal: Eur Heart J
link: http://www.ncbi.nlm.nih.gov/pubmed/24159190
trait: Serum dimethylarginine levels (asymmetric)
initial_samplesize: 5110 European ancestry individuals
region: 1p22.3
chrom: 1
reported_genes: DDAH1
mapped_gene: DDAH1
snp_gene_ids: 23576
strongest_risk_snp: rs28489187
strongest_risk_allele: G
snps: rs28489187
snp_id_current: 28489187
context: intron
pvalue_mlog: 40
ci_95: [0.32-0.42] unit increase
platform: Illumina and Affymetrix [10,085,758] (Imputed)
cnv: N
study:
Genome-wide association study on dimethylarginines reveals novel AGXT2 variants associated with heart rate variability but not with overall mortality.


dbdate: 2014-04-15
author: Goodbourn PT
date: 2013-10-23
journal: Genes Brain Behav
link: http://www.ncbi.nlm.nih.gov/pubmed/24152035
trait: Contrast sensitivity
initial_samplesize: 985 European ancestry individuals
replication_samplesize: N/A
region: 1q21.1
chrom: 1
reported_genes: PDZK1
mapped_gene: PDZK1
snp_gene_ids: 5174
strongest_risk_snp: rs1797052
snps: rs1797052
snp_id_current: 1797052
context: UTR-5
pvalue_mlog: 8.096910013008056
ci_95: [NR] unit increase
platform: Illumina [642,758]
cnv: N
study:
Variants in the 1q21 risk region are associated with a visual endophenotype of autism and schizophrenia.


dbdate: 2014-04-15
author: Goodbourn PT
date: 2013-10-23
journal: Genes Brain Behav
link: http://www.ncbi.nlm.nih.gov/pubmed/24152035
trait: Contrast sensitivity
initial_samplesize: 985 European ancestry individuals
replication_samplesize: N/A
region: 12q13.2
chrom: 12
mapped_gene: OR6C64P
snp_gene_ids: 403281
strongest_risk_snp: rs12230513
snps: rs12230513
snp_id_current: 12230513
pvalue_mlog: 5.301029995663981
ci_95: [NR] unit decrease
platform: Illumina [642,758]
cnv: N
reported_genes:
OR9K2, OR10A7, OR6C74, OR6C6, OR6C1, OR6C3, OR6C75, OR6C65, OR6C76, OR6C2, OR6C70, OR6C68, OR6C4, OR10P1


dbdate: 2014-04-25
author: Gelernter J
date: 2013-10-19
journal: Biol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/24143882
trait: Opioid sensitivity
replication_samplesize: 2,116 European ancestry individuals, 4,496 African American individuals
region: 4p14
chrom: 4
reported_genes: APBB2
mapped_gene: APBB2
snp_gene_ids: 323
strongest_risk_snp: rs114070671
snps: rs114070671
snp_id_current: 114070671
context: intron
pvalue_mlog: 7
platform: Illumina [988,306]
cnv: N
study:
Genome-wide association study of opioid dependence: multiple associations mapped to calcium and potassium pathways.

initial_samplesize:
1,383 European ancestry cases, 996 European ancestry controls, 683 African American cases, 2,635 African Amercian controls


dbdate: 2014-04-26
author: Wu Y
date: 2013-10-14
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24105470
trait: Adiponectin levels
initial_samplesize: 6,110 East Asian ancestry individuals, 1,717 Filipino ancestry individuals
replication_samplesize: 10,252 East Asian ancestry individuals
region: 10q26.12
chrom: 10
reported_genes: WDR11, FGFR2
mapped_gene: LINC01153
snp_gene_ids: 101927889
strongest_risk_snp: rs3943077
strongest_risk_allele: A
snps: rs3943077
snp_id_current: 3943077
context: ncRNA
pvalue_mlog: 13.52287874528034
ci_95: [0.050-0.090] unit increase
platform: Illumina and Affymetrix [~2.5 million] (imputed)
cnv: N
study:
A meta-analysis of genome-wide association studies for adiponectin levels in East Asians identifies a novel locus near WDR11-FGFR2.


dbdate: 2014-04-10
author: Levine DM
date: 2013-10-13
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24121790
trait: Barrett's esophagus
initial_samplesize: 2,416 European ancestry cases, 3,206 European ancestry controls
replication_samplesize: 759 European ancestry cases, 6,911 European ancestry controls
region: 3p13
chrom: 3
reported_genes: FOXP1
mapped_gene: HMGB1P36 - FOXP1
upstream_gene_id: 100419968
downstream_gene_id: 27086
strongest_risk_snp: rs2687201
strongest_risk_allele: T
snps: rs2687201
snp_id_current: 2687201
context: Intergenic
pvalue_mlog: 5.698970004336018
ci_95: [1.10-1.26]
platform: Illumina [922,031]
cnv: N
study:
A genome-wide association study identifies new susceptibility loci for esophageal adenocarcinoma and Barrett's esophagus.


dbdate: 2014-04-11
author: Jones RM
date: 2013-10-11
journal: Front Hum Neurosci
link: http://www.ncbi.nlm.nih.gov/pubmed/24133439
trait: Social autistic-like traits
initial_samplesize: 965 European ancestry young adults
region: 4q31.3
chrom: 4
reported_genes: DCLK2
mapped_gene: DCLK2
snp_gene_ids: 166614
strongest_risk_snp: rs11947645
strongest_risk_allele: A
snps: rs11947645
snp_id_current: 11947645
context: intron
pvalue_mlog: 5.999999999999999
ci_95: [3.17-7.48] unit increase
platform: Illumina [2,462,046] (Imputed)
cnv: N
study:
Genome-wide association study of autistic-like traits in a general population study of young adults.


dbdate: 2014-04-25
author: Pei YF
date: 2013-10-08
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24064335
study: Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity.
trait: Body mass index
replication_samplesize: 4,979 European ancestry individuals, 2,740 Han Chinese ancestry individuals
region: 18q21.32
chrom: 18
reported_genes: MC4R
mapped_gene: RPS3AP49 - MC4R
upstream_gene_id: 400652
downstream_gene_id: 4160
strongest_risk_snp: rs6567160
strongest_risk_allele: C
snps: rs6567160
snp_id_current: 6567160
context: Intergenic
pvalue_mlog: 18.09691001300805
ci_95: [0.070-0.110] kg/m2 increase
platform: Affymetrix and Illumina [4,325,550] (Imputed)
cnv: N
initial_samplesize:
8,463 European ancestry individuals, 7,478 African American individuals, 3,348 Hispanic individuals, 1,624 Han Chinese ancestry individuals


dbdate: 2014-04-25
author: Pei YF
date: 2013-10-08
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24064335
study: Meta-analysis of genome-wide association data identifies novel susceptibility loci for obesity.
trait: Fat body mass
replication_samplesize: 4,967 European ancestry individuals, 2,740 Han Chinese ancestry individuals
region: 18q21.32
chrom: 18
reported_genes: MC4R
mapped_gene: RPS3AP49 - MC4R
upstream_gene_id: 400652
downstream_gene_id: 4160
strongest_risk_snp: rs6567160
strongest_risk_allele: C
snps: rs6567160
snp_id_current: 6567160
context: Intergenic
pvalue_mlog: 10.52287874528034
ci_95: [0.07-0.11] unit increase
platform: Affymetrix and Illumina [4,325,550] (Imputed)
cnv: N
initial_samplesize:
6,433 European ancestry individuals, 709 African American individuals, 408 Hispanic individuals, 1,622 Han Chinese ancestry individuals


dbdate: 2014-04-08
author: Song YQ
date: 2013-10-08
journal: J Clin Invest
link: http://www.ncbi.nlm.nih.gov/pubmed/24216480
study: Lumbar disc degeneration is linked to a carbohydrate sulfotransferase 3 variant.
trait: Disc degeneration (lumbar)
initial_samplesize: 366 Japanese ancestry cases, 3,331 Japanese ancestry controls
region: 10q22.1
chrom: 10
reported_genes: CHST3
mapped_gene: CHST3 - SPOCK2
upstream_gene_id: 9469
downstream_gene_id: 9806
strongest_risk_snp: rs1245582
snps: rs1245582
snp_id_current: 1245582
context: Intergenic
pvalue_mlog: 5.999999999999999
platform: Illumina [464,775]
cnv: N
replication_samplesize:
1,628 East Asian ancestry cases, 17,469 East Asian ancestry controls, 399 European ancestry cases, 5,035 European ancestry control


dbdate: 2014-05-01
author: Hanson RL
date: 2013-10-07
journal: Diabetes
link: http://www.ncbi.nlm.nih.gov/pubmed/24101674
trait: Type 2 diabetes
region: 2q36.3
chrom: 2
reported_genes: DNER
mapped_gene: DNER
snp_gene_ids: 92737
strongest_risk_snp: rs1861612
strongest_risk_allele: T
snps: rs1861612
snp_id_current: 1861612
context: intron
pvalue_mlog: 7.154901959985742
ci_95: [NR]
platform: Affymetrix [453,654]
cnv: N
study:
A genome-wide association study in American Indians implicates DNER as a susceptibility locus for type 2 diabetes.

initial_samplesize:
278 American Indian ancestry young-onset cases, 129 American Indian ancestry cases, and 424 American Indian ancestry controls from 514 sibships

replication_samplesize:
1,273 American Indian ancestry cases, 1,635 American Indian ancestry controls, 793 cases, 3,133 controls


dbdate: 2014-04-04
author: Li Y
date: 2013-10-06
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24097066
trait: Sj�gren's syndrome
initial_samplesize: 542 Han Chinese ancestry cases, 1,050 Han Chinese ancestry controls
replication_samplesize: 1,303 Han Chinese ancestry cases, 2,727 Han Chinese ancestry controls
region: 7q11.23
chrom: 7
reported_genes: GTF2I, GTF2IRD1
mapped_gene: GTF2I;LOC101926943
snp_gene_ids: 2969;101926943
strongest_risk_snp: rs117026326
strongest_risk_allele: T
snps: rs117026326
snp_id_current: 117026326
context: intron;intron
pvalue_mlog: 53
ci_95: [1.99-2.42]
platform: Affymetrix [556,134]
cnv: N
study:
A genome-wide association study in Han Chinese identifies a susceptibility locus for primary Sj&#x000f6;gren's syndrome at 7q11.23.


dbdate: 2014-03-26
author: Hong KW
date: 2013-09-30
journal: Genomics Inform
link: http://www.ncbi.nlm.nih.gov/pubmed/24124408
trait: Orthostatic hypotension
initial_samplesize: 667 Korean ancestry cases, 5,761 Korean ancestry controls
region: 2p12
chrom: 2
reported_genes: CTNNA2
mapped_gene: LRRTM1 - MTND4P25
upstream_gene_id: 347730
downstream_gene_id: 100873246
strongest_risk_snp: rs6736587
strongest_risk_allele: C
snps: rs6736587
snp_id_current: 6736587
context: Intergenic
pvalue_mlog: 7.30102999566398
ci_95: [NR] mmHg decrease
platform: Affymetrix [333,651]
cnv: N
study:
Genome-wide association study of orthostatic hypotension and supine-standing blood pressure changes in two korean populations.


dbdate: 2014-04-04
author: Orozco G
date: 2013-09-24
journal: Arthritis Rheumatol
link: http://www.ncbi.nlm.nih.gov/pubmed/24449572
trait: Rheumatoid arthritis
initial_samplesize: 3,034 European ancestry cases, 5,271 European ancestry controls
replication_samplesize: 4,726 European ancestry cases, 2,625 European ancestry controls
region: 22q12.2
chrom: 22
reported_genes: GATSL3
mapped_gene: GATSL3
snp_gene_ids: 652968
strongest_risk_snp: rs1043099
snps: rs1043099
snp_id_current: 1043099
context: UTR-3
pvalue_mlog: 8.154901959985743
ci_95: [1.12-1.27]
platform: Affymetrix [1,831,729] (imputed)
cnv: N
study:
Novel rheumatoid arthritis susceptibility locus at 22q12 identified in an extended UK genome-wide association study.


dbdate: 2014-04-09
author: Wang Q
date: 2013-09-24
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/24086445
trait: Gray matter volume (schizophrenia interaction)
initial_samplesize: 74 Han Chinese ancestry cases, 51 Han Chinese ancestry controls
region: 6q21
chrom: 6
reported_genes: HS3ST5
mapped_gene: HS3ST5
snp_gene_ids: 222537
strongest_risk_snp: rs9488343
snps: rs9488343
snp_id_current: 9488343
context: intron
pvalue_mlog: 6.154901959985743
ci_95: [NR] unit increase
platform: [1,983,054] (Imputed)
cnv: N
study:
Genome-wide association analysis with gray matter volume as a quantitative phenotype in first-episode treatment-na&#x000ef;ve patients with schizophrenia.


dbdate: 2014-03-27
author: O'Seaghdha CM
date: 2013-09-19
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24068962
trait: Calcium levels
initial_samplesize: 39,400 European ancestry individuals
replication_samplesize: Up to 21,679 European ancestry individuals
region: 3q21.1
chrom: 3
reported_genes: CASR
mapped_gene: CASR
snp_gene_ids: 846
strongest_risk_snp: rs1801725
strongest_risk_allele: T
snps: rs1801725
snp_id_current: 1801725
context: missense
pvalue_mlog: 85.04575749056067
ci_95: [0.063-0.079] unit increase
platform: Illumina & Affymetrix [2.5 million] (Imputed)
cnv: N
study:
Meta-analysis of genome-wide association studies identifies six new Loci for serum calcium concentrations.


dbdate: 2014-04-04
author: Chen Z
date: 2013-09-18
journal: J Med Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24049095
trait: Follicule stimulating hormone
initial_samplesize: 1,999 Han Chinese ancestry individuals
replication_samplesize: 1,496 East Asian ancestry individuals
region: 15q21.2
chrom: 15
reported_genes: CYP19A1
mapped_gene: CYP19A1
snp_gene_ids: 1588
strongest_risk_snp: rs2414095
strongest_risk_allele: A
snps: rs2414095
snp_id_current: 2414095
context: intron
pvalue_mlog: 15.69897000433602
ci_95: [0.090-0.130] unit increase
platform: Illumina [709,211]
cnv: N
study:
Genome-wide association study of sex hormones, gonadotropins and sex hormone-binding protein in Chinese men.


dbdate: 2014-04-10
author: Chimusa ER
date: 2013-09-18
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24057671
trait: Tuberculosis
initial_samplesize: 642 South African coloured cases, 91 South African coloured controls
region: 21q22.3
chrom: 21
reported_genes: C2CD2
mapped_gene: C2CD2
snp_gene_ids: 25966
strongest_risk_snp: rs451390
strongest_risk_allele: G
snps: rs451390
snp_id_current: 451390
context: intron
pvalue_mlog: 6.698970004336019
ci_95: [NR]
platform: Affymetrix [up to 4,467,279] (imputed)
cnv: N
study:
Genome-wide association study of ancestry-specific TB risk in the South African Coloured population.


dbdate: 2014-03-26
author: Kleber ME
date: 2013-09-18
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24047826
trait: Homoarginine levels
initial_samplesize: 5,143 European ancestry individuals
replication_samplesize: 1,474 European ancestry individuals
region: 15q21.1
chrom: 15
reported_genes: GATM
mapped_gene: SLC28A2 - GATM
upstream_gene_id: 9153
downstream_gene_id: 2628
strongest_risk_snp: rs1153858
strongest_risk_allele: C
snps: rs1153858
snp_id_current: 1153858
context: Intergenic
pvalue_mlog: 44.99999999999999
ci_95: [NR] unit decrease
platform: Affymetrix & Illumina [2,543,887] (Imputed)
cnv: N
study:
Genome-wide association study identifies 3 genomic loci significantly associated with serum levels of homoarginine: the AtheroRemo Consortium.


dbdate: 2014-03-23
author: Pyun JA
date: 2013-09-16
journal: Menopause
link: http://www.ncbi.nlm.nih.gov/pubmed/24045676
trait: Menopause (age at onset)
initial_samplesize: 1,827 Korean ancestry females
region: 10q26.13
chrom: 10
reported_genes: RPS26P39, BUB3
mapped_gene: RPS26P39 - GPR26
upstream_gene_id: 100128168
downstream_gene_id: 2849
strongest_risk_snp: rs11597068
strongest_risk_allele: G
snps: rs11597068
snp_id_current: 11597068
context: Intergenic
pvalue_mlog: 7
ci_95: [0.86-1.88] unit increase
platform: Affymetrix [343,107]
cnv: N
study:
Genome-wide association studies and epistasis analyses of candidate genes related to age at menarche and age at natural menopause in a Korean population.


dbdate: 2014-04-01
author: McGrath LM
date: 2013-09-13
journal: Am J Med Genet B Neuropsychiatr Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24039173
trait: Functional impairment in major depressive disorder, bipolar disorder and schizophrenia
initial_samplesize: 2,246 European ancestry individuals
region: 3q24
chrom: 3
reported_genes: Intergenic
mapped_gene: PLSCR5 - RPL21P71
upstream_gene_id: 389158
downstream_gene_id: 729962
strongest_risk_snp: rs4681346
snps: rs4681346
snp_id_current: 4681346
context: Intergenic
pvalue_mlog: 5.522878745280337
platform: Affymetrix [1,633,452] (Imputed)
cnv: N
study:
Genetic predictors of risk and resilience in psychiatric disorders: a cross-disorder genome-wide association study of functional impairment in major depressive disorder, bipolar disorder, and schizophrenia.


dbdate: 2014-03-22
author: Sandholm N
date: 2013-09-12
journal: J Am Soc Nephrol
link: http://www.ncbi.nlm.nih.gov/pubmed/24029427
study: Chromosome 2q31.1 associates with ESRD in women with type 1 diabetes.
trait: End-stage renal disease in Type 1 diabetics
region: 2q31.1
chrom: 2
reported_genes: SP3, CDCA7
mapped_gene: CDCA7 - RPL5P7
upstream_gene_id: 83879
downstream_gene_id: 344178
strongest_risk_snp: rs4972593
strongest_risk_allele: A
snps: rs4972593
snp_id_current: 4972593
context: Intergenic
pvalue_mlog: 7.397940008672037
ci_95: [1.47-2.24]
platform: Illumina [2.4 Million] (imputed)
cnv: N
initial_samplesize:
258 European ancestry female cases, 935 European ancestry female controls, 387 European ancestry male cases, 655 European ancestry male controls

replication_samplesize:
178 European ancestry female cases, 594 European ancestry female controls, 251 European ancestry male cases, 494 European ancestry male controls, 252 female cases, 479 female controls, 256 male cases, 342 male controls


dbdate: 2014-03-25
author: Shameer K
date: 2013-09-12
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24026423
trait: Mean platelet volume
initial_samplesize: 6,291 European ancestry individuals
region: 12q13.13
chrom: 12
reported_genes: COPZ1, NFE2
mapped_gene: NFE2
snp_gene_ids: 4778
strongest_risk_snp: rs10506328
strongest_risk_allele: C
snps: rs10506328
snp_id_current: 10506328
context: intron
pvalue_mlog: 8.698970004336019
ci_95: [NR] unit decrease
platform: Illumina [476,395]
cnv: N
study:
A genome- and phenome-wide association study to identify genetic variants influencing platelet count and volume and their pleiotropic effects.


dbdate: 2014-04-04
author: Wu Y
date: 2013-09-10
journal: J Lipid Res
link: http://www.ncbi.nlm.nih.gov/pubmed/24023260
trait: Lipid traits
initial_samplesize: 1,782 Filipino ancestry mothers
replication_samplesize: 1,719 Filipino ancestry offsprings
region: 19q13.32
chrom: 19
reported_genes: APOE
mapped_gene: APOE
snp_gene_ids: 348
strongest_risk_snp: rs7412
strongest_risk_allele: T
snps: rs7412
snp_id_current: 7412
context: missense
pvalue_mlog: 52.52287874528033
ci_95: [0.42-0.54] unit decrease
platform: Affymetrix [~3.7 million] (Imputed)
cnv: N
study:
Genetic association with lipids in Filipinos: waist circumference modifies an APOA5 effect on triglyceride levels.


dbdate: 2014-03-22
author: Kasperaviciute D
date: 2013-09-06
journal: Brain
link: http://www.ncbi.nlm.nih.gov/pubmed/24014518
trait: Mesial temporal lobe epilepsy with hippocampal sclerosis
initial_samplesize: up to 1,018 European ancestry cases, 7,552 European ancestry controls
replication_samplesize: 959 European ancestry cases, 3,591 European ancestry controls
region: 2q24.3
chrom: 2
reported_genes: SCN1A
mapped_gene: SCN1A;LOC101929680
snp_gene_ids: 6323;101929680
strongest_risk_snp: rs7587026
strongest_risk_allele: A
snps: rs7587026
snp_id_current: 7587026
context: intron;intron
pvalue_mlog: 7.397940008672037
ci_95: [1.15-1.34]
platform: Illumina [531,164]
cnv: N
study:
Epilepsy, hippocampal sclerosis and febrile seizures linked by common genetic variation around SCN1A.


dbdate: 2014-04-02
author: Miyake A
date: 2013-09-04
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/24023777
trait: Adolescent idiopathic scoliosis (severe)
initial_samplesize: 554 Japanese ancestry cases, 1,474 Japanese ancestry controls
replication_samplesize: 839 East Asian ancestry cases, 10,149 East Asian ancestry controls
region: 17q24.3
chrom: 17
reported_genes: SOX9, KCNJ2
mapped_gene: CASC17 - LINC01152
upstream_gene_id: 101928165
downstream_gene_id: 102606463
strongest_risk_snp: rs12946942
strongest_risk_allele: T
snps: rs12946942
snp_id_current: 12946942
context: Intergenic
pvalue_mlog: 11.22184874961635
ci_95: [1.76-2.77]
platform: Illumina [455,121]
cnv: N
study:
Identification of a susceptibility locus for severe adolescent idiopathic scoliosis on chromosome 17q24.3.


dbdate: 2014-03-26
author: Kelly TN
date: 2013-09-03
journal: Hypertension
link: http://www.ncbi.nlm.nih.gov/pubmed/24001895
trait: Blood pressure
initial_samplesize: 22,275 East Asian ancestry individuals, 4,325 South East Asian ancestry individuals
replication_samplesize: 28,783 East Asian ancestry individuals
region: 10q24.32
chrom: 10
reported_genes: CYP17A1
mapped_gene: CYP17A1
snp_gene_ids: 1586
strongest_risk_snp: rs3824755
strongest_risk_allele: C
snps: rs3824755
snp_id_current: 3824755
context: intron
pvalue_mlog: 5.999999999999999
ci_95: [0.3-0.7] mm of mercury decrease
platform: Affymetrix & Illumina [~2.4 million] (Imputed)
cnv: N
study:
Genome-wide association study meta-analysis reveals transethnic replication of mean arterial and pulse pressure loci.


dbdate: 2013-12-10
author: Xie G
date: 2013-09-01
journal: Arthritis Rheum
link: http://www.ncbi.nlm.nih.gov/pubmed/23740775
trait: Wegener's granulomatosis
initial_samplesize: 459 European ancestry cases, 1,503 European ancestry controls
replication_samplesize: 291 European ancestry cases, 317 European ancestry controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DPB1, HLA-DPB2, HSD17B8, RING1, COL11A2, RXRB, HLA-DOA, HLA-DPB1*04
mapped_gene: HLA-DPB1
snp_gene_ids: 3115
strongest_risk_snp: rs9277554
strongest_risk_allele: C
snps: rs9277554
snp_id_current: 9277554
context: UTR-3
pvalue_mlog: 49.69897000433602
ci_95: [3.33-5.00]
platform: Illumina [287,802]
cnv: N
study:
Association of granulomatosis with polyangiitis (Wegener's) with HLA-DPB1*04 and SEMA6A gene variants: evidence from genome-wide analysis.


dbdate: 2014-03-15
author: Jiang J
date: 2013-08-30
journal: Front Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24009623
trait: Response to mTOR inhibitor (everolimus)
region: 8p21.2
chrom: 8
reported_genes: Intergenic
mapped_gene: NKX2-6 - STC1
upstream_gene_id: 137814
downstream_gene_id: 6781
strongest_risk_snp: rs218869
snps: rs218869
snp_id_current: 218869
context: Intergenic
pvalue_mlog: 5.397940008672037
ci_95: [NR] unit increase
platform: Illumina and Affymetrix [1,348,798]
cnv: N
study:
Genome-wide association study for biomarker identification of Rapamycin and Everolimus using a lymphoblastoid cell line system.

initial_samplesize:
87 European ancestry individuals, 91 African American individuals, 94 Han Chinese ancestry individuals


dbdate: 2014-03-18
author: Migliorini G
date: 2013-08-30
journal: Blood
link: http://www.ncbi.nlm.nih.gov/pubmed/23996088
trait: Acute lymphoblastic leukemia (B-cell precursor)
initial_samplesize: 1,658 European ancestry child cases, 4,723 European ancestry controls
replication_samplesize: 1,449 European ancestry child cases, 1,488 European ancestry controls
region: 10p12.2
chrom: 10
reported_genes: PIP4K2A
mapped_gene: PIP4K2A
snp_gene_ids: 5305
strongest_risk_snp: rs10828317
strongest_risk_allele: T
snps: rs10828317
snp_id_current: 2230469
context: missense
pvalue_mlog: 8.698970004336019
ci_95: [1.15-1.32]
platform: Illumina [382,776] (imputed)
cnv: N
study:
Variation at 10p12.2 and 10p14 influences risk of childhood B-cell acute lymphoblastic leukemia and phenotype.


dbdate: 2014-03-18
author: Evangelou E
date: 2013-08-29
journal: Ann Rheum Dis
link: http://www.ncbi.nlm.nih.gov/pubmed/23989986
trait: Osteoarthritis (hip)
initial_samplesize: up to 4,734 European ancestry cases, up to 46,903 European ancestry controls
replication_samplesize: up to 6,928 European ancestry cases, up to 20,570 European ancestry controls
region: 20q13.12
chrom: 20
reported_genes: NCOA3
mapped_gene: ZMYND8 - RPL35AP
upstream_gene_id: 23613
downstream_gene_id: 140716
strongest_risk_snp: rs6094710
strongest_risk_allele: A
snps: rs6094710
snp_id_current: 6094710
context: Intergenic
pvalue_mlog: 9.698970004336017
ci_95: [1.18-1.39]
platform: Illumina [2,567,279] (imputed)
cnv: N
study:
A meta-analysis of genome-wide association studies identifies novel variants associated with osteoarthritis of the hip.


dbdate: 2014-03-14
author: Himes BE
date: 2013-08-28
journal: BMC Med Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23984888
study: ITGB5 and AGFG1 variants are associated with severity of airway responsiveness.
trait: Airway hyperresponsiveness
initial_samplesize: 994 European ancestry asthma cases
region: 2q36.3
chrom: 2
reported_genes: ITGB5, AGFG1
mapped_gene: AGFG1
snp_gene_ids: 3267
strongest_risk_snp: rs6731443
strongest_risk_allele: G
snps: rs6731443
snp_id_current: 6731443
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [NR] unit decrease
platform: Affymetrix [2,154,322] (imputed)
cnv: N
replication_samplesize:
650 European ancestry asthma cases, 3,354 European ancestry chronic obstructive pulmonary disease cases


dbdate: 2014-03-14
author: Qi L
date: 2013-08-28
journal: JAMA
link: http://www.ncbi.nlm.nih.gov/pubmed/23982368
trait: Cardiovascular heart disease in diabetics
initial_samplesize: 669 European ancestry cases, 1,641 European ancestry controls
replication_samplesize: 848 European ancestry cases, 1,030 European ancestry controls
region: 1q25.3
chrom: 1
reported_genes: ZNF648, GLUL
mapped_gene: ZNF648 - GS1-122H1.2
upstream_gene_id: 127665
downstream_gene_id: 400799
strongest_risk_snp: rs10911021
strongest_risk_allele: C
snps: rs10911021
snp_id_current: 10911021
context: Intergenic
pvalue_mlog: 7.698970004336018
ci_95: [1.22-1.51]
platform: Affymetrix [2,543,016]
cnv: N
study:
Association between a genetic variant related to glutamic acid metabolism and coronary heart disease in individuals with type 2 diabetes.


dbdate: 2014-03-14
author: Miller FW
date: 2013-08-27
journal: Arthritis Rheum
link: http://www.ncbi.nlm.nih.gov/pubmed/23983088
trait: Dermatomyositis
initial_samplesize: 1,178 European ancestry cases, 4,724 European ancestry controls
region: 2q33.1[rs7572733]; 2q33.1[rs6738825]
reported_genes: PLCL1
strongest_risk_snp: rs7572733
snps: rs7572733, rs6738825
ci_95: [1.14-1.39]
platform: Illumina [up to 242,876]
cnv: N
study:
Genome-wide association study of dermatomyositis reveals genetic overlap with other autoimmune disorders.


dbdate: 2014-03-18
author: Ripke S
date: 2013-08-25
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23974872
study: Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
trait: Schizophrenia
initial_samplesize: 5,001 European ancestry cases, 6,243 European ancestry controls, 8,832 cases, 12,067 controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DRB9
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs114002140
strongest_risk_allele: A
snps: rs114002140
snp_id_current: 9268895
pvalue_mlog: 13.04575749056067
ci_95: [1.63-1.71]
platform: Affymetrix & Illumina [9,871,789]
cnv: N
replication_samplesize:
4,801 European ancestry cases, 4,741 European ancestry controls, 2,612 cases, 15,021 controls, 581 trios


dbdate: 2014-03-18
author: Ripke S
date: 2013-08-25
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23974872
study: Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
trait: Schizophrenia
initial_samplesize: 5,001 European ancestry cases, 6,243 European ancestry controls, 8,832 cases, 12,067 controls
region: 10q24.32
chrom: 10
mapped_gene: AS3MT;C10orf32-ASMT
snp_gene_ids: 57412;100528007
strongest_risk_snp: rs7085104
strongest_risk_allele: A
snps: rs7085104
snp_id_current: 7085104
context: nearGene-5;intron
pvalue_mlog: 12.39794000867204
ci_95: [1.08-1.14]
platform: Affymetrix & Illumina [9,871,789]
cnv: N
replication_samplesize:
4,801 European ancestry cases, 4,741 European ancestry controls, 2,612 cases, 15,021 controls, 581 trios

reported_genes:
C10orf32, AS3MT, CALHM1, CALHM2, CALHM3,CNNM2, CYP17A1, INA, MIR1307, NT5C2, PCGF6, PDCD11, SFXN2, ST13P13, TAF5, USMG5, WBP1L


dbdate: 2014-03-18
author: Ripke S
date: 2013-08-25
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23974872
study: Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
trait: Schizophrenia
initial_samplesize: 5,001 European ancestry cases, 6,243 European ancestry controls, 8,832 cases, 12,067 controls
region: 19p13.11
chrom: 19
mapped_gene: MAU2 - GATAD2A
upstream_gene_id: 23383
downstream_gene_id: 54815
strongest_risk_snp: rs2905424
strongest_risk_allele: T
snps: rs2905424
snp_id_current: 2905424
context: Intergenic
pvalue_mlog: 8.522878745280337
ci_95: [1.06-1.12]
platform: Affymetrix & Illumina [9,871,789]
cnv: N
reported_genes:
MAU2, CILP2, GATAD2A, GMIP, HAPLN4, LPAR2, MIR640, NCAN, NDUFA13, PBX4, SUGP1, TM6SF2, TSSK6, YJEFN3


dbdate: 2014-03-18
author: Ripke S
date: 2013-08-25
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23974872
study: Genome-wide association analysis identifies 13 new risk loci for schizophrenia.
trait: Schizophrenia
initial_samplesize: 5,001 European ancestry cases, 6,243 European ancestry controls, 8,832 cases, 12,067 controls
region: 3p21.1
chrom: 3
mapped_gene: ITIH3
snp_gene_ids: 3699
strongest_risk_snp: rs4687552
strongest_risk_allele: T
snps: rs4687552
snp_id_current: 4687552
context: intron
pvalue_mlog: 8
ci_95: [1.06-1.11]
platform: Affymetrix & Illumina [9,871,789]
cnv: N
reported_genes:
ITIH3, ALAS1, ALDOAP1, BAP1, C3orf78, DNAH1, GLT8D1, GLYCTK, GNL3, ITIH1, ITIH4, MIR135A1, MIRLET7G, MUSTN1, NEK4, NISCH, NT5DC2, PBRM1, PHF7, PPM1M, RFT1, SEMA3G, SFMBT1, SPCS1, STAB1, TLR9, TMEM110, TNNC1, TWF2, WDR82


dbdate: 2014-03-19
author: Allen EK
date: 2013-08-23
journal: J Assoc Res Otolaryngol
link: http://www.ncbi.nlm.nih.gov/pubmed/23974705
trait: Otitis media (chronic/recurrent)
initial_samplesize: 373 cases and 229 controls from 143 families
replication_samplesize: 932 European ancestry cases and 652 European ancestry controls from 441 families
region: 2q31.1
chrom: 2
reported_genes: CDCA7, SP3
mapped_gene: CDCA7 - RPL5P7
upstream_gene_id: 83879
downstream_gene_id: 344178
strongest_risk_snp: rs10497394
strongest_risk_allele: G
snps: rs10497394
snp_id_current: 10497394
context: Intergenic
pvalue_mlog: 7.698970004336018
ci_95: [1.30-1.70]
platform: Illumina [324,748]
cnv: N
study:
A genome-wide association study of chronic otitis media with effusion and recurrent otitis media identifies a novel susceptibility locus on chromosome 2.


dbdate: 2014-03-14
author: Sabater-Lleal M
date: 2013-08-22
journal: Circulation
link: http://www.ncbi.nlm.nih.gov/pubmed/23969696
trait: Fibrinogen
initial_samplesize: 91,323 European ancestry individuals
replication_samplesize: 8,423 African American individuals, 1,447 Hispanic individuals
region: 14q24.1
chrom: 14
reported_genes: ACTN1
mapped_gene: ZFP36L1 - MAGOH3P
upstream_gene_id: 677
downstream_gene_id: 90352
strongest_risk_snp: rs434943
strongest_risk_allele: A
snps: rs434943
snp_id_current: 434943
context: Intergenic
pvalue_mlog: 8
ci_95: [0.005-0.009] unit increase
platform: Affymetrix & Illumina [2,515,567] (Imputed)
cnv: N
study:
Multiethnic meta-analysis of genome-wide association studies in &gt;100 000 subjects identifies 23 fibrinogen-associated Loci but no strong evidence of a causal association between circulating fibrinogen and cardiovascular disease.


dbdate: 2014-03-21
author: Feenstra B
date: 2013-08-21
journal: JAMA
link: http://www.ncbi.nlm.nih.gov/pubmed/23989729
trait: Infantile hypertrophic pyloric stenosis
initial_samplesize: 1,001 European ancestry cases, 2,371 European ancestry controls
region: 11q23.3
chrom: 11
reported_genes: APOA1
mapped_gene: APOA1
snp_gene_ids: 335
strongest_risk_snp: rs12721025
strongest_risk_allele: A
snps: rs12721025
snp_id_current: 12721025
context: nearGene-3
pvalue_mlog: 9.698970004336017
ci_95: [1.38-1.83]
platform: Illumina [9,737,928] (Imputed)
cnv: N
study:
Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis.

replication_samplesize:
925 European ancestry cases, 1,621 European ancestry controls, 738 other ancestry cases, 697 other ancestry controls


dbdate: 2014-03-15
author: Franceschini N
date: 2013-08-20
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23972371
trait: Blood pressure
initial_samplesize: 28,190 African American individuals, 1,188 Nigerian ancestry individuals
region: 6q22.33
chrom: 6
reported_genes: RSPO3
mapped_gene: RPS4XP9 - RSPO3
upstream_gene_id: 442257
downstream_gene_id: 84870
strongest_risk_snp: rs13209747
strongest_risk_allele: T
snps: rs13209747
snp_id_current: 13209747
context: Intergenic
pvalue_mlog: 9.522878745280336
ci_95: [0.44-1.26] unit increase
platform: Affymetrix & Illumina [~2.42 million] (Imputed)
cnv: N
study:
Genome-wide association analysis of blood-pressure traits in African-ancestry individuals reveals common associated genes in African and non-African populations.

replication_samplesize:
69,395 European ancestry individuals, 5,266 African American individuals, 6,497 African ancestry individuals, 19,601 East Asian ancestry individuals


dbdate: 2014-03-20
author: Gelernter J
date: 2013-08-20
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/23958962
trait: Cocaine dependence
replication_samplesize: 4,498 European ancestry individuals, 2,114 African American individuals
region: 2q14.2
chrom: 2
reported_genes: STEAP3
mapped_gene: STEAP3
snp_gene_ids: 55240
strongest_risk_snp: rs72840936
snps: rs72840936
snp_id_current: 72840936
context: nearGene-3
pvalue_mlog: 5.522878745280337
platform: Illumina [37,426,733] imputed
cnv: N
study:
Genome-wide association study of cocaine dependence and related traits: FAM53B identified as a risk gene.

initial_samplesize:
1,809 European ancestry cases, 570 European ancestry controls, 2,482 African American cases, 836 African American controls


dbdate: 2014-03-13
author: Ledda M
date: 2013-08-20
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23966204
trait: Bitter taste perception
initial_samplesize: 503 Brazillian ancestry individuals
replication_samplesize: 104 Brazillian ancestry individuals
region: 12p13.2[rs2708377]; 12p13.2[rs8181]
reported_genes: Tas2R46
strongest_risk_snp: rs2708377
snps: rs2708377, rs8181
ci_95: [0.071-0.149] unit decrease
platform: Illumina [~1 million]
cnv: N
study:
GWAS of human bitter taste perception identifies new loci and reveals additional complexity of bitter taste genetics.


dbdate: 2014-03-20
author: Speed D
date: 2013-08-19
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23962720
trait: Epilepsy (remission after treatment)
initial_samplesize: 889 Epilepsy cases
region: 1q21.1
chrom: 1
mapped_gene: RNF115
snp_gene_ids: 27246
strongest_risk_snp: rs12744221
strongest_risk_allele: C
snps: rs12744221
snp_id_current: 12744221
context: intron
pvalue_mlog: 5.221848749616356
ci_95: [NR]
platform: Illumina [6,923,995] (Imputed)
cnv: N
study:
A genome-wide association study and biological pathway analysis of epilepsy prognosis in a prospective cohort of newly treated epilepsy.


dbdate: 2014-03-11
author: Hara K
date: 2013-08-14
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23945395
study: Genome-wide association study identifies three novel loci for type 2 diabetes.
trait: Type 2 diabetes
initial_samplesize: 5,976 Japanese ancestry cases, 20,829 Japanese ancestry controls
region: 7q32.1
chrom: 7
reported_genes: MIR129, LEP
mapped_gene: LOC101928423
snp_gene_ids: 101928423
strongest_risk_snp: rs791595
strongest_risk_allele: A
snps: rs791595
snp_id_current: 791595
context: intron
pvalue_mlog: 12.52287874528034
ci_95: [1.12-1.22]
platform: Illumina [6,209,637] (Imputed)
cnv: N
replication_samplesize:
18,207 Japanese ancestry cases, 6,780 Japanese ancestry controls, 6,209 Chinese ancestry cases, 7,205 Chinese ancestry controls


dbdate: 2014-03-04
author: Yu B
date: 2013-08-11
journal: Genet Epidemiol
link: http://www.ncbi.nlm.nih.gov/pubmed/23934736
trait: Metabolite levels (X-11787)
initial_samplesize: 1,260 African American individuals
region: 8q13.3
chrom: 8
reported_genes: SLCO5A1
mapped_gene: SLCO5A1
snp_gene_ids: 81796
strongest_risk_snp: rs10090896
strongest_risk_allele: A
snps: rs10090896
snp_id_current: 10090896
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [0.02-0.06] unit decrease
platform: Affymetrix [~2.5 million] (Imputed)
cnv: N
study:
Genome-wide association study of a heart failure related metabolomic profile among African Americans in the Atherosclerosis Risk in Communities (ARIC) study.


dbdate: 2014-02-25
author: Cheng CY
date: 2013-08-08
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/24144296
trait: Axial length
initial_samplesize: 12,531 European ancestry individuals
replication_samplesize: 8,216 Asian ancestry individuals
region: 1p34.3
chrom: 1
reported_genes: RSPO1, SNIP1, RSPO1, GNL2, EPHA10, DNALI1, CDCA8, C1orf109
mapped_gene: RSPO1
snp_gene_ids: 284654
strongest_risk_snp: rs4074961
strongest_risk_allele: T
snps: rs4074961
snp_id_current: 4074961
context: intron
pvalue_mlog: 12.39794000867204
ci_95: [0.053-0.092] unit increase
platform: Illumina [2.5 million] (Imputed)
cnv: N
study:
Nine loci for ocular axial length identified through genome-wide association studies, including shared loci with refractive error.


dbdate: 2014-03-20
author: Ostensson M
date: 2013-08-02
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/23936387
trait: Celiac disease
initial_samplesize: 206 European ancestry trios
region: 17q22
chrom: 17
reported_genes: ANKFN1, NOG
mapped_gene: ANKFN1 - RPL39P33
upstream_gene_id: 162282
downstream_gene_id: 100271521
strongest_risk_snp: rs17760268
strongest_risk_allele: C
snps: rs17760268
snp_id_current: 17760268
context: Intergenic
pvalue_mlog: 5.397940008672037
platform: Illumina [944,512] (Imputed)
cnv: N
study:
A possible mechanism behind autoimmune disorders discovered by genome-wide linkage and association analysis in celiac disease.


dbdate: 2014-03-01
author: Hayes MG
date: 2013-07-31
journal: Diabetes
link: http://www.ncbi.nlm.nih.gov/pubmed/23903356
trait: Glycemic traits (pregnancy)
replication_samplesize: 2,798 European ancestry individuals, 228 French Canadian founder population individuals
region: 2p23.3
chrom: 2
reported_genes: GCKR
mapped_gene: GCKR
snp_gene_ids: 2646
strongest_risk_snp: rs1260326
strongest_risk_allele: T
snps: rs1260326
snp_id_current: 1260326
context: missense
pvalue_mlog: 12.22184874961636
ci_95: [NR] unit decrease
platform: Illumina [up to 945,994] (imputed)
cnv: N
study:
Identification of HKDC1 and BACE2 as genes influencing glycemic traits during pregnancy through genome-wide association studies.

initial_samplesize:
1,367 European ancestry individuals, 817 Hispanic individuals, 1,075 Afro-Caribbean ancestry individuals, 1,178 Thai ancestry individuals


dbdate: 2014-02-25
author: Kim DS
date: 2013-07-31
journal: Int Arch Allergy Immunol
link: http://www.ncbi.nlm.nih.gov/pubmed/23921680
trait: Allergic dermatitis (nickel)
initial_samplesize: up to 24 Korean ancestry cases, 52 Korean ancestry controls
region: 12q22
chrom: 12
reported_genes: NTN4
mapped_gene: NTN4;PGAM1P5
snp_gene_ids: 59277;100132594
strongest_risk_snp: rs2367563
strongest_risk_allele: A
snps: rs2367563
snp_id_current: 2367563
context: intron;intron
pvalue_mlog: 5.397940008672037
ci_95: [NR]
platform: Affymetrix [NR]
cnv: N
study:
A genome-wide association study in Koreans identifies susceptibility loci for allergic nickel dermatitis.


dbdate: 2014-02-21
author: McRae JF
date: 2013-07-31
journal: Curr Biol
link: http://www.ncbi.nlm.nih.gov/pubmed/23910658
trait: Odorant perception (&beta;-damascenone)
initial_samplesize: 187 European ancestry individuals
replication_samplesize: 89 European ancestry individuals
region: 11q12.1
chrom: 11
reported_genes: OR5BN1P
mapped_gene: OR8H3 - OR5BN1P
upstream_gene_id: 390152
downstream_gene_id: 81204
strongest_risk_snp: rs2220004
snps: rs2220004
snp_id_current: 2220004
context: Intergenic
pvalue_mlog: 6.698970004336019
ci_95: [NR] unit increase
platform: Affymetrix [619,656]
cnv: N
study:
Identification of regions associated with variation in sensitivity to food-related odors in the human genome.


dbdate: 2014-02-18
author: Pistis G
date: 2013-07-31
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/23935956
trait: Red blood cell traits
initial_samplesize: 1,664 Val Borbera individuals
replication_samplesize: 619 Friuli Venezia Giulia individuals, 16,145 European ancestry individuals
region: 22q12.3
chrom: 22
reported_genes: TMPRSS6
mapped_gene: TMPRSS6
snp_gene_ids: 164656
strongest_risk_snp: rs2413450
strongest_risk_allele: T
snps: rs2413450
snp_id_current: 2413450
context: intron
pvalue_mlog: 6.397940008672037
ci_95: [0.0060-0.0138] unit decrease
platform: Illumina [~2.5 Million] (imputed)
cnv: N
study:
Genome wide association analysis of a founder population identified TAF3 as a gene for MCHC in humans.


dbdate: 2014-03-02
author: Pooley KA
date: 2013-07-29
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23900074
trait: Telomere length
initial_samplesize: 2,240 European ancestry individuals
replication_samplesize: 11,024 breast cancer cases, 15,065 controls
region: 3q26.2
chrom: 3
reported_genes: TERC
mapped_gene: LRRC34
snp_gene_ids: 151827
strongest_risk_snp: rs10936601
snps: rs10936601
snp_id_current: 10936601
context: intron
pvalue_mlog: 14.39794000867204
ci_95: [0.00029-0.00051] unit increase
platform: Illumina and Perlegen [2,448,093] (imputed)
cnv: N
study:
A genome-wide association scan (GWAS) for mean telomere length within the COGS project: identified loci show little association with hormone-related cancer risk.


dbdate: 2014-02-08
author: Wang H
date: 2013-07-29
journal: Pediatrics
link: http://www.ncbi.nlm.nih.gov/pubmed/23897914
study: A genome-wide association study (GWAS) for bronchopulmonary dysplasia.
trait: Bronchopulmonary dysplasia
replication_samplesize: 371 newborn cases, 424 newborn controls
region: 11q22.3
chrom: 11
reported_genes: CARD17,CASP1P1
mapped_gene: CARD17
snp_gene_ids: 440068
strongest_risk_snp: rs11226613
strongest_risk_allele: T
snps: rs11226613
snp_id_current: 11226613
context: nearGene-5
pvalue_mlog: 5.301029995663981
ci_95: [0.6-0.81]
platform: Illumina [1,795,103]
cnv: N
initial_samplesize:
117 African American newborn cases, 108 African American newborn controls, 448 Hispanic newborn cases, 460 Hispanic newborn controls, 74 Asian or Pacific Islander ancestry newborn cases, 93 Asian or Pacific Islander ancestry newborn control, 174 European ancestry newborn cases, 216 European ancestry newborn controls, 14 newborn cases, 22 newborn controls


dbdate: 2014-02-25
author: McLaren PJ
date: 2013-07-25
journal: PLoS Pathog
link: http://www.ncbi.nlm.nih.gov/pubmed/23935489
trait: HIV-1 susceptibility
initial_samplesize: 6,334 European ancestry cases, 7,247 European ancestry controls
region: 6p21.33
chrom: 6
reported_genes: HLA-B, HLA-C
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs4418214
strongest_risk_allele: C
snps: rs4418214
snp_id_current: 4418214
pvalue_mlog: 10.39794000867204
platform: Illumina & Affymetrix [~8 million] Imputed
cnv: N
study:
Association study of common genetic variants and HIV-1 acquisition in 6,300 infected cases and 7,200 controls.


dbdate: 2014-02-11
author: Weidinger S
date: 2013-07-25
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23886662
trait: Atopic dermatitis
initial_samplesize: 1563 European ancestry cases, 4,054 European ancestry controls
replication_samplesize: 2,286 European ancestry cases, 3,160 European ancestry controls
region: 5q31.1
chrom: 5
reported_genes: IL13, RAD50
mapped_gene: IL13
snp_gene_ids: 3596
strongest_risk_snp: rs1295686
strongest_risk_allele: A
snps: rs1295686
snp_id_current: 1295686
context: intron
pvalue_mlog: 16.69897000433602
ci_95: [1.283-1.49]
platform: Illumina [2,406,139] (Imputed)
cnv: N
study:
A genome-wide association study of atopic dermatitis identifies loci with overlapping effects on asthma and psoriasis.


dbdate: 2014-01-22
author: Bezzina CR
date: 2013-07-21
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23872634
trait: Brugada syndrome
initial_samplesize: 312 European ancestry cases, 1,115 European ancestry controls
region: 3p22.2
chrom: 3
reported_genes: SCN5A
mapped_gene: SCN5A
snp_gene_ids: 6331
strongest_risk_snp: rs11708996
strongest_risk_allele: C
snps: rs11708996
snp_id_current: 11708996
context: intron
pvalue_mlog: 14
ci_95: [1.51-1.99]
platform: Affymetrix [360,149]
cnv: N
study:
Common variants at SCN5A-SCN10A and HEY2 are associated with Brugada syndrome, a rare disease with high risk of sudden cardiac death.

replication_samplesize:
594 European ancestry cases, 806 European ancestry controls, 208 Japanese ancestry cases, 1,1016 Japanese controls


dbdate: 2014-02-04
author: Power RA
date: 2013-07-15
journal: Am J Med Genet B Neuropsychiatr Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23857890
trait: Major depressive disorder
initial_samplesize: 805 European ancestry cases, 805 European ancestry controls
region: 16q24.1
chrom: 16
reported_genes: IRF8
mapped_gene: MIR6774 - LINC01082
upstream_gene_id: 102466732
downstream_gene_id: 100506542
strongest_risk_snp: rs8050326
strongest_risk_allele: A
snps: rs8050326
snp_id_current: 8050326
context: Intergenic
pvalue_mlog: 6.522878745280337
ci_95: [1.26-1.76]
platform: Illumina [457,670]
cnv: N
study:
Genome-wide association analysis accounting for environmental factors through propensity-score matching: application to stressful live events in major depressive disorder.


dbdate: 2014-02-04
author: Yang SK
date: 2013-07-14
journal: Gut
link: http://www.ncbi.nlm.nih.gov/pubmed/23850713
trait: Crohn's disease
initial_samplesize: 532 Korean ancestry cases, 733 Korean ancestry controls
replication_samplesize: 1,779 Korean ancestry cases, 1,709 Korean ancestry controls
region: 1p31.3
chrom: 1
reported_genes: IL23R
mapped_gene: IL23R
snp_gene_ids: 149233
strongest_risk_snp: rs76418789
strongest_risk_allele: G
snps: rs76418789
snp_id_current: 76418789
context: missense
pvalue_mlog: 9.698970004336017
ci_95: [1.64-2.58]
platform: Illumina [5,664,371] (imputed)
cnv: N
study:
Genome-wide association study of Crohn's disease in Koreans revealed three new susceptibility loci and common attributes of genetic susceptibility across ethnic populations.


dbdate: 2014-02-12
author: Kobayashi D
date: 2013-07-08
journal: Mol Pain
link: http://www.ncbi.nlm.nih.gov/pubmed/23834954
trait: Sensory disturbances after bilateral sagittal split ramus osteotomy
initial_samplesize: Up to 105 individuals
replication_samplesize: Up to 200 individuals
region: 1p13.3
chrom: 1
reported_genes: CSF1
mapped_gene: EPS8L3 - CSF1
upstream_gene_id: 79574
downstream_gene_id: 1435
strongest_risk_snp: rs6537883
snps: rs6537883
snp_id_current: 6537883
context: Intergenic
pvalue_mlog: 5.522878745280337
platform: Illumina [243,229]
cnv: N
study:
Genome-wide association study of sensory disturbances in the inferior alveolar nerve after bilateral sagittal split ramus osteotomy.


dbdate: 2014-02-05
author: The Blue Mountains Eye Study (BMES) and The Wellcome Trust Case Control Consortium 2 (WTCCC2)
date: 2013-07-07
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23836780
trait: Intraocular pressure
initial_samplesize: 2,175 European ancestry individuals
replication_samplesize: 4,866 European ancestry individuals
region: 7p21.3
chrom: 7
reported_genes: ICA1, GLCCI1
mapped_gene: GLCCI1 - ICA1
upstream_gene_id: 113263
downstream_gene_id: 3382
strongest_risk_snp: rs59072263
strongest_risk_allele: G
snps: rs59072263
snp_id_current: 59072263
context: Intergenic
pvalue_mlog: 8
ci_95: [0.29-0.61] unit increase
platform: Illumina [6,235,970]
cnv: N
study:
Genome-wide association study of intraocular pressure identifies the GLCCI1/ICA1 region as a glaucoma susceptibility locus.


dbdate: 2014-02-06
author: Ding L
date: 2013-07-05
journal: Hum Genomics
link: http://www.ncbi.nlm.nih.gov/pubmed/23829686
trait: Asthma (childhood onset)
initial_samplesize: 429 European ancestry affected offspring trios
replication_samplesize: 52 African American affected offspring trios, 46 Hispanic affected offspring trios
region: 9p23
chrom: 9
reported_genes: Intergenic
mapped_gene: JKAMPP1 - TYRP1
upstream_gene_id: 100049717
downstream_gene_id: 7306
strongest_risk_snp: rs16929097
snps: rs16929097
snp_id_current: 16929097
context: Intergenic
pvalue_mlog: 8.096910013008056
platform: Affymetrix [786,195]
cnv: N
study:
Rank-based genome-wide analysis reveals the association of ryanodine receptor-2 gene variants with childhood asthma among human populations.


dbdate: 2014-01-31
author: van Meurs JB
date: 2013-07-03
journal: Am J Clin Nutr
link: http://www.ncbi.nlm.nih.gov/pubmed/23824729
trait: Homocysteine levels
initial_samplesize: 44,147 European ancestry individuals
region: 1p36.22
chrom: 1
reported_genes: MTHFR
mapped_gene: MTHFR
snp_gene_ids: 4524
strongest_risk_snp: rs1801133
strongest_risk_allele: A
snps: rs1801133
snp_id_current: 1801133
context: missense
pvalue_mlog: 103.397940008672
ci_95: [0.14-0.17] unit increase
platform: Affymetrix & Illumina [2,090,256] (Imputed)
cnv: N
study:
Common genetic loci influencing plasma homocysteine concentrations and their effect on risk of coronary artery disease.


dbdate: 2014-01-10
author: Dorajoo R
date: 2013-07-02
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/23844046
trait: C-reactive protein
region: 19q13.32
chrom: 19
reported_genes: APOE
mapped_gene: TOMM40
snp_gene_ids: 10452
strongest_risk_snp: rs2075650
strongest_risk_allele: G
snps: rs2075650
snp_id_current: 2075650
context: intron
pvalue_mlog: 20.69897000433602
ci_95: [NR] unit increase
platform: Illumina [Up to 1,745,429] (Imputed)
cnv: N
study:
Are C-reactive protein associated genetic variants associated with serum levels and retinal markers of microvascular pathology in Asian populations from Singapore?

initial_samplesize:
2,179 Chinese ancestry individuals, 2,275 Malay ancestry individuals, 2,238 Asian Indian ancestry individuals


dbdate: 2014-01-08
author: Bonnelykke K
date: 2013-06-30
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23817571
trait: Allergic sensitization
initial_samplesize: 5,789 European ancestry cases, 10,056 European ancestry controls
replication_samplesize: 6,114 European ancestry cases, 9,920 European ancestry controls
region: 11q13.5
chrom: 11
reported_genes: C11orf30, LRRC32
mapped_gene: C11orf30 - LRRC32
upstream_gene_id: 56946
downstream_gene_id: 2615
strongest_risk_snp: rs2155219
strongest_risk_allele: T
snps: rs2155219
snp_id_current: 2155219
context: Intergenic
pvalue_mlog: 18
ci_95: [1.13-1.22]
platform: Affymetrix & Illumina [~2.5 million] (Imputed)
cnv: N
study:
Meta-analysis of genome-wide association studies identifies ten loci influencing allergic sensitization.


dbdate: 2014-01-09
author: Hinds DA
date: 2013-06-30
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23817569
trait: Self-reported allergy
initial_samplesize: 53,862 European ancestry individuals
region: 1p36.22
chrom: 1
reported_genes: PEX14
mapped_gene: PEX14
snp_gene_ids: 5195
strongest_risk_snp: rs2056417
strongest_risk_allele: A
snps: rs2056417
snp_id_current: 2056417
context: intron
pvalue_mlog: 6.397940008672037
ci_95: [0.041-0.091] unit decrease
platform: Illumina [2.4 million] (Imputed)
cnv: N
study:
A genome-wide association meta-analysis of self-reported allergy identifies shared and allergy-specific susceptibility loci.


dbdate: 2013-12-12
author: Shi Y
date: 2013-06-30
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23817570
trait: Cervical cancer
initial_samplesize: Up to 1,364 Han Chinese ancestry cases, up to 3,028 Han Chinese ancestry controls
replication_samplesize: 4,167 Han Chinese ancestry cases, 7,196 Han Chinese ancestry controls
region: 4q12
chrom: 4
reported_genes: EXOC1
mapped_gene: EXOC1
snp_gene_ids: 55763
strongest_risk_snp: rs13117307
strongest_risk_allele: T
snps: rs13117307
snp_id_current: 13117307
context: intron
pvalue_mlog: 9.522878745280336
ci_95: [1.19-1.38]
platform: Affymetrix [563,339]
cnv: N
study:
A genome-wide association study identifies two new cervical cancer susceptibility loci at 4q12 and 17q12.


dbdate: 2013-12-12
author: Leandro-Garcia LJ
date: 2013-06-17
journal: J Med Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23776197
trait: Paclitaxel-induced neuropathy
initial_samplesize: 143 European ancestry individuals
region: 2q36.1
chrom: 2
reported_genes: EPHA4
mapped_gene: MIR4268 - EPHA4
upstream_gene_id: 100422959
downstream_gene_id: 2043
strongest_risk_snp: rs17348202
strongest_risk_allele: G
snps: rs17348202
snp_id_current: 17348202
context: Intergenic
pvalue_mlog: 5.999999999999999
ci_95: [2.57-9.13]
platform: Illumina [518,577]
cnv: N
study:
Genome-wide association study identifies ephrin type A receptors implicated in paclitaxel induced peripheral sensory neuropathy.


dbdate: 2013-12-11
author: Kim YJ
date: 2013-06-10
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23760081
trait: Chronic hepatitis B infection
initial_samplesize: 400 Korean ancestry cases, 1,000 Korean ancestry controls
replication_samplesize: 971 Korean ancestry cases, 1,938 Korean ancestry controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DP
mapped_gene: HLA-DPB1
snp_gene_ids: 3115
strongest_risk_snp: rs9277535
snps: rs9277535
snp_id_current: 9277535
context: UTR-3
pvalue_mlog: 39.39794000867203
ci_95: [1.72-2.08]
platform: Illumina [719,265]
cnv: N
study:
A genome-wide association study identified new variants associated with the risk of chronic hepatitis B.


dbdate: 2013-12-11
author: Martin JE
date: 2013-06-10
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23740937
trait: Systemic lupus erythematosus and Systemic sclerosis
region: 1p34.3
chrom: 1
reported_genes: KIAA0319L
mapped_gene: KIAA0319L
snp_gene_ids: 79932
strongest_risk_snp: rs2275247
snps: rs2275247
snp_id_current: 2275247
context: intron
pvalue_mlog: 10
ci_95: [NR]
platform: Illumina [NR]
cnv: N
study:
A systemic sclerosis and systemic lupus erythematosus pan-meta-GWAS reveals new shared susceptibility loci.

initial_samplesize:
up to 2,761 European ancestry systemic sclerosis cases, 769 European ancestry systemic lupus erythematosus cases, 7,381 European ancestry controls

replication_samplesize:
up to 1,578 European ancestry systemic sclerosis cases, 1,727 European ancestry systemic lupus erythematosus cases, 6,893 European ancestry controls


dbdate: 2013-12-05
author: Turner ST
date: 2013-06-10
journal: Hypertension
link: http://www.ncbi.nlm.nih.gov/pubmed/23753411
trait: Response to diuretic therapy in hypertension
initial_samplesize: 424 European ancestry individuals
replication_samplesize: 841 European ancestry individuals
region: 20q13.32
chrom: 20
reported_genes: TH1L, GNAS, EDN3
mapped_gene: NELFCD
snp_gene_ids: 51497
strongest_risk_snp: rs2273359
strongest_risk_allele: C
snps: rs2273359
snp_id_current: 2273359
context: intron
pvalue_mlog: 7.221848749616355
ci_95: [NR] mm Hg increase
platform: Illumina [1,092,841] (imputed)
cnv: N
study:
Genomic association analysis of common variants influencing antihypertensive response to hydrochlorothiazide.


dbdate: 2013-12-05
author: Tan DE
date: 2013-06-09
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23749188
trait: B cell non-Hodgkin lymphoma
initial_samplesize: 253 Singaporean Chinese ancestry cases; 1,438 Singaporean Chinese ancestry controls
replication_samplesize: 1,175 Han Chinese ancestry cases, 5,492 Han Chinese ancestry controls
region: 3q27.3
chrom: 3
reported_genes: BCL6, LPP
mapped_gene: BCL6 - LPP-AS2
upstream_gene_id: 604
downstream_gene_id: 339929
strongest_risk_snp: rs6773854
strongest_risk_allele: C
snps: rs6773854
snp_id_current: 6773854
context: Intergenic
pvalue_mlog: 12.52287874528034
ci_95: [1.31-1.59]
platform: Illumina [550,946]
cnv: N
study:
Genome-wide association study of B cell non-Hodgkin lymphoma identifies 3q27 as a susceptibility locus in the Chinese population.


dbdate: 2013-12-16
author: Kapoor M
date: 2013-06-07
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23743675
trait: Alcohol consumption
initial_samplesize: 2,322 European ancestry individuals from 118 families, 2,593 European ancestry individuals
region: 1q41
chrom: 1
reported_genes: ESRRG
mapped_gene: ESRRG
snp_gene_ids: 2104
strongest_risk_snp: rs7553212
snps: rs7553212
snp_id_current: 7553212
context: intron
pvalue_mlog: 5.154901959985742
ci_95: [0.031-0.109] unit increase
platform: Illumina [4,058,415] (Imputed)
cnv: N
study:
A meta-analysis of two genome-wide association studies to identify novel loci for maximum number of alcoholic drinks.


dbdate: 2014-01-09
author: Randall JC
date: 2013-06-06
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23754948
trait: Sexual dimorphism in anthropometric traits
initial_samplesize: up to 60,586 Europrean ancestry men, up to 73,137 European ancestry women
replication_samplesize: up to 62,395 Europrean ancestry men, up to 74,657 European ancestry women
region: 6q27
chrom: 6
reported_genes: DACT2
mapped_gene: DACT2 - SMOC2
upstream_gene_id: 168002
downstream_gene_id: 64094
strongest_risk_snp: rs6915443
strongest_risk_allele: T
snps: rs6915443
snp_id_current: 6915443
context: Intergenic
pvalue_mlog: 5.522878745280337
platform: Affymetrix & Illumina [~2.8 million] (Imputed)
cnv: N
study:
Sex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.


dbdate: 2013-12-06
author: Yazar S
date: 2013-06-06
journal: Mol Vis
link: http://www.ncbi.nlm.nih.gov/pubmed/23761726
trait: Corneal astigmatism
initial_samplesize: 2,784 European ancestry individuals
region: 12p11.21
chrom: 12
reported_genes: AMN1
mapped_gene: RPLP2P4 - RPL12P32
upstream_gene_id: 100271347
downstream_gene_id: 100132795
strongest_risk_snp: rs1151008
strongest_risk_allele: G
snps: rs1151008
snp_id_current: 1151008
context: Intergenic
pvalue_mlog: 5.999999999999999
ci_95: [0.085-0.203] unit decrease
platform: Illumina [~2.5 million] (Imputed)
cnv: N
study:
Interrogation of the platelet-derived growth factor receptor alpha locus and corneal astigmatism in Australians of Northern European ancestry: results of a genome-wide association study.


dbdate: 2013-12-03
author: Perera MA
date: 2013-06-05
journal: Lancet
link: http://www.ncbi.nlm.nih.gov/pubmed/23755828
trait: Warfarin maintenance dose
initial_samplesize: 533 African American individuals
replication_samplesize: 432 African American individuals
region: 10q23.33
chrom: 10
reported_genes: CYP2C, CYP2C18, CYP2C9, CYP2C8, CYP2C19
mapped_gene: HELLS - CTBP2P2
upstream_gene_id: 3070
downstream_gene_id: 100130970
strongest_risk_snp: rs12777823
snps: rs12777823
snp_id_current: 12777823
context: Intergenic
pvalue_mlog: 11.30102999566398
platform: Illumina [3,044,177] (Imputed)
cnv: N
study:
Genetic variants associated with warfarin dose in African-American individuals: a genome-wide association study.


dbdate: 2013-12-03
author: Renteria ME
date: 2013-06-03
journal: Twin Res Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23725790
trait: DNA methylation (parent-of-origin)
initial_samplesize: 1,024 European ancestry individuals
region: 11p15.5
chrom: 11
reported_genes: H19, MIR675
mapped_gene: MIR675 - INS-IGF2
upstream_gene_id: 100033819
downstream_gene_id: 723961
strongest_risk_snp: rs4930103
strongest_risk_allele: A
snps: rs4930103
snp_id_current: 4930103
context: Intergenic
pvalue_mlog: 15.30102999566398
platform: Illumina [515,966]
cnv: N
study:
GWAS of DNA methylation variation within imprinting control regions suggests parent-of-origin association.


dbdate: 2013-11-20
author: Yang L
date: 2013-05-31
journal: Am J Med Genet B Neuropsychiatr Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23728934
trait: Attention deficit hyperactivity disorder
initial_samplesize: 1,040 Han Chinese ancestry cases, 963 Han Chinese ancestry controls
region: 18q22.1
chrom: 18
reported_genes: TMX3
mapped_gene: MTL3P - TMX3
upstream_gene_id: 4531
downstream_gene_id: 54495
strongest_risk_snp: rs17232800
snps: rs17232800
snp_id_current: 17232800
context: Intergenic
pvalue_mlog: 5.522878745280337
platform: Affymetrix [656,051]
cnv: N
study:
Polygenic transmission and complex neuro developmental network for attention deficit hyperactivity disorder: genome-wide association study of both common and rare variants.


dbdate: 2013-12-03
author: Coram MA
date: 2013-05-29
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23726366
trait: HDL cholesterol
initial_samplesize: 7,917 African American individuals, 3,506 Hispanic individuals
replication_samplesize: 7,138 African American individuals
region: 7q21.11
chrom: 7
reported_genes: CD36
mapped_gene: CD36 - SEMA3C
upstream_gene_id: 948
downstream_gene_id: 10512
strongest_risk_snp: rs2366858
strongest_risk_allele: C
snps: rs2366858
snp_id_current: 2366858
context: Intergenic
pvalue_mlog: 9.221848749616356
ci_95: [NR] unit increase
platform: Affymetrix [NR]
cnv: N
study:
Genome-wide characterization of shared and distinct genetic components that influence blood lipid levels in ethnically diverse human populations.


dbdate: 2013-11-14
author: Xie P
date: 2013-05-28
journal: Biol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/23726511
study: Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
trait: Post-traumatic stress disorder
region: 4q32.3
chrom: 4
reported_genes: TLL1
mapped_gene: TLL1
snp_gene_ids: 7092
strongest_risk_snp: rs6812849
snps: rs6812849
snp_id_current: 6812849
context: intron
pvalue_mlog: 8.522878745280337
platform: Illumina [up to 871,502]
cnv: N
initial_samplesize:
300 European ancestry cases, up to 1,538 European ancestry controls, 444 African American cases, up to 2,936 African American controls

replication_samplesize:
207 European ancestry cases, up to 1,692 European ancestry controls, 89 African American cases, up to 655 African American controls


dbdate: 2013-11-14
author: Xie P
date: 2013-05-28
journal: Biol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/23726511
study: Genome-wide association study identifies new susceptibility loci for posttraumatic stress disorder.
trait: Post-traumatic stress disorder (asjusted for relatedness)
region: 7p12.1
chrom: 7
reported_genes: COBL
mapped_gene: CICP17 - POM121L12
upstream_gene_id: 642663
downstream_gene_id: 285877
strongest_risk_snp: rs406001
snps: rs406001
snp_id_current: 406001
context: Intergenic
pvalue_mlog: 7.698970004336018
platform: Illumina [up to 871,502]
cnv: N
initial_samplesize:
up to 308 European ancestry cases, up to 1,538 European ancestry controls, up to 456 African American cases, up to 2,936 African American controls


dbdate: 2013-11-20
author: Cordell HJ
date: 2013-05-26
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23708191
trait: Congenital heart disease
region: 4p16.2
chrom: 4
reported_genes: STX18, MSX1, LOC100507266
mapped_gene: STX18-AS1
snp_gene_ids: 100507266
strongest_risk_snp: rs870142
strongest_risk_allele: A
snps: rs870142
snp_id_current: 870142
context: intron
pvalue_mlog: 9.522878745280336
ci_95: [NR]
platform: Illumina [514,952]
cnv: N
study:
Genome-wide association study of multiple congenital heart disease phenotypes identifies a susceptibility locus for atrial septal defect at chromosome 4p16.

initial_samplesize:
1,479 European ancestry congenital heart disease cases, 340 European ancestry ostium secundum atrial septal defect cases, 5,159 European ancestry controls

replication_samplesize:
417 European ancestry ostium secundum atrial septal defect cases, 209 European ancestry ventricular septal defect cases, 2,520 European ancestry controls


dbdate: 2013-11-15
author: Hu Z
date: 2013-05-26
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23708190
trait: Congenital heart malformation
initial_samplesize: 945 Han Chinese ancestry cases, 1,246 Han Chinese ancestry controls
replication_samplesize: 2,160 Han Chinese ancestry cases, 3,866 Han Chinese ancestry controls
region: 1p12
chrom: 1
reported_genes: TBX15, SPAG17
mapped_gene: RNA5SP56 - PSMC1P12
upstream_gene_id: 100873294
downstream_gene_id: 644094
strongest_risk_snp: rs2474937
strongest_risk_allele: C
snps: rs2474937
snp_id_current: 2474937
context: Intergenic
pvalue_mlog: 9.096910013008054
ci_95: [1.26-1.56]
platform: Illumina [708,275]
cnv: N
study:
A genome-wide association study identifies two risk loci for congenital heart malformations in Han Chinese populations.


dbdate: 2013-11-15
author: Kerns SL
date: 2013-05-26
journal: Radiother Oncol
link: http://www.ncbi.nlm.nih.gov/pubmed/23719583
trait: Adverse response to radiation therapy
region: 4q28.3
chrom: 4
reported_genes: LOC646316, PCDH18
mapped_gene: TERF1P3 - SERF1AP1
upstream_gene_id: 646316
downstream_gene_id: 100131921
strongest_risk_snp: rs10519410
snps: rs10519410
snp_id_current: 10519410
context: Intergenic
pvalue_mlog: 5.999999999999999
ci_95: [1.0-2.3]
platform: Affymetrix [614,453]
cnv: N
study:
Genome-wide association study identifies a region on chromosome 11q14.3 associated with late rectal bleeding following radiation therapy for prostate cancer.

initial_samplesize:
79 European, African, Asian, and Hispanic ancestry cases, 241 European, African, Asian, and Hispanic ancestry controls

replication_samplesize:
107 European, African, Asian, and Hispanic ancestry cases, 671 European, African, Asian, and Hispanic ancestry controls


dbdate: 2013-11-15
author: Fatemifar G
date: 2013-05-23
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23704328
trait: Primary tooth development (number of teeth)
initial_samplesize: 11,513 European ancestry individuals
region: 2q35
chrom: 2
mapped_gene: TNP1 - DIRC3
upstream_gene_id: 7141
downstream_gene_id: 729582
strongest_risk_snp: rs10932688
strongest_risk_allele: G
snps: rs10932688
snp_id_current: 10932688
context: Intergenic
pvalue_mlog: 7.522878745280337
ci_95: [0.092-0.194] unit increase
platform: Illumina [2,446,724] (Imputed)
cnv: N
study:
Genome-wide association study of primary tooth eruption identifies pleiotropic loci associated with height and craniofacial distances.


dbdate: 2013-11-13
author: Ding K
date: 2013-05-20
journal: G3 (Bethesda)
link: http://www.ncbi.nlm.nih.gov/pubmed/23696099
trait: Red blood cell traits
initial_samplesize: 1904 African American individuals
replication_samplesize: 411 African American individuals
region: 11p15.4
chrom: 11
mapped_gene: OR51V1 - HBB
upstream_gene_id: 283111
downstream_gene_id: 3043
strongest_risk_snp: rs7120391
strongest_risk_allele: C
snps: rs7120391
snp_id_current: 7120391
context: Intergenic
pvalue_mlog: 8.301029995663981
ci_95: [0.20-0.40] unit increase
platform: Illumina [907,954]
cnv: N
study:
Genetic variants that confer resistance to malaria are associated with red blood cell traits in African-Americans: an electronic medical record-based genome-wide association study.


dbdate: 2013-11-14
author: Kim JJ
date: 2013-05-16
journal: J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23677057
trait: Coronary arterial lesions in patients with Kawasaki disease
initial_samplesize: 17 Korean ancestry cases, 123 Korean ancestry controls
replication_samplesize: 32 Korean ancestry cases, 191 Korean ancestry controls
region: 5q22.3
chrom: 5
reported_genes: KCNN2
mapped_gene: KCNN2;LOC101927078
snp_gene_ids: 3781;101927078
strongest_risk_snp: rs17136627
strongest_risk_allele: A
snps: rs17136627
snp_id_current: 17136627
context: intron;intron
pvalue_mlog: 7.698970004336018
ci_95: [4.13-38.5]
platform: Affymetrix [652,397]
cnv: N
study:
Identification of KCNN2 as a susceptibility locus for coronary artery aneurysms in Kawasaki disease using genome-wide association analysis.


dbdate: 2013-11-03
author: Graff M
date: 2013-05-12
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23669352
trait: Body mass index
initial_samplesize: Up to 13,627 European ancestry individuals
replication_samplesize: Up to 16,253 European ancestry individuals
region: 2p25.3
chrom: 2
reported_genes: TMEM18
mapped_gene: FAM150B - TMEM18
upstream_gene_id: 285016
downstream_gene_id: 129787
strongest_risk_snp: rs12463617
strongest_risk_allele: A
snps: rs12463617
snp_id_current: 12463617
context: Intergenic
pvalue_mlog: 16.52287874528034
ci_95: [0.076-0.124] unit decrease
platform: Illumina & Affymetrix [557,887] (imputed)
cnv: N
study:
Genome-wide analysis of BMI in adolescents and young adults reveals additional insight into the effects of genetic loci over the life course.


dbdate: 2013-09-27
author: Kou I
date: 2013-05-12
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23666238
study: Genetic variants in GPR126 are associated with adolescent idiopathic scoliosis.
trait: Scoliosis
initial_samplesize: 1,033 Japanese ancestry cases, 1,473 Japanese ancestry controls
region: 6q24.1
chrom: 6
reported_genes: GPR126
mapped_gene: GPR126
snp_gene_ids: 57211
strongest_risk_snp: rs6570507
snps: rs6570507
snp_id_current: 6570507
context: intron
pvalue_mlog: 14
ci_95: [1.20-1.35]
platform: Illumina [465,762]
cnv: N
replication_samplesize:
786 Japanese ancestry cases, 24,466 Japanese ancestry controls, 743 Han Chinese ancestry cases, 1,209 Han Chinese ancestry controls, 447 European ancestry cases, 737 European ancestry controls


dbdate: 2013-11-09
author: Ruark E
date: 2013-05-12
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23666240
trait: Testicular germ cell tumor
initial_samplesize: 986 European ancestry cases, 4,946 European ancestry controls
replication_samplesize: 1,064 European ancestry cases, 10,082 European ancestry controls
region: 1q22
chrom: 1
reported_genes: SLC25A44
mapped_gene: SLC25A44
snp_gene_ids: 9673
strongest_risk_snp: rs2072499
strongest_risk_allele: G
snps: rs2072499
snp_id_current: 2072499
context: intron
pvalue_mlog: 7.522878745280337
ci_95: [1.08-1.30]
platform: Illumina [307,291]
cnv: N
study:
Identification of nine new susceptibility loci for testicular cancer, including variants near DAZL and PRDM14.


dbdate: 2013-09-28
author: Dubinsky MC
date: 2013-05-09
journal: Inflamm Bowel Dis
link: http://www.ncbi.nlm.nih.gov/pubmed/23665963
trait: Crohn's disease (need for surgery)
region: 9q34.3
chrom: 9
reported_genes: RXRA, COL5A1
mapped_gene: MIR4669 - COL5A1
upstream_gene_id: 100616236
downstream_gene_id: 1289
strongest_risk_snp: rs11103429
strongest_risk_allele: G
snps: rs11103429
snp_id_current: 11103429
context: Intergenic
pvalue_mlog: 5.221848749616356
ci_95: [2.10-6.30]
platform: Illumina [483,359]
cnv: N
study:
Multidimensional prognostic risk assessment identifies association between IL12B variation and surgery in Crohn's disease.

initial_samplesize:
239 European ancestry cases that required surgery within 5 year, 375 European ancestry cases that did not require surgery within 5 years


dbdate: 2013-09-21
author: Tang W
date: 2013-05-05
journal: Genet Epidemiol
link: http://www.ncbi.nlm.nih.gov/pubmed/23650146
trait: Venous thromboembolism
initial_samplesize: 1,618 European ancestry cases, 42,881 European ancestry controls
replication_samplesize: 3,231 European ancestry cases, 3,536 European ancestry controls
region: 1q24.2
chrom: 1
reported_genes: F5
mapped_gene: F5
snp_gene_ids: 2153
strongest_risk_snp: rs6427196
strongest_risk_allele: C
snps: rs6427196
snp_id_current: 6427196
context: UTR-3
pvalue_mlog: 50.39794000867204
ci_95: [1.89-2.28]
platform: Illumina & Affymetrix [2,543,885] (Imputed)
cnv: N
study:
A genome-wide association study for venous thromboembolism: the extended cohorts for heart and aging research in genomic epidemiology (CHARGE) consortium.


dbdate: 2013-09-20
author: Wu C
date: 2013-05-05
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23644492
trait: Esophageal squamous cell cancer (length of survival)
initial_samplesize: 1,331 Chinese ancestry cases
replication_samplesize: 1,062 Chinese ancestry individuals
region: 18q12.2
chrom: 18
reported_genes: SLC39A6
mapped_gene: SLC39A6
snp_gene_ids: 25800
strongest_risk_snp: rs1050631
strongest_risk_allele: T
snps: rs1050631
snp_id_current: 1050631
context: cds-synon
pvalue_mlog: 7.397940008672037
ci_95: [1.19-1.43]
platform: Affymetrix [665,999]
cnv: N
study:
Genome-wide association study identifies common variants in SLC39A6 associated with length of survival in esophageal squamous-cell carcinoma.


dbdate: 2013-11-14
author: Low SK
date: 2013-05-04
journal: Cancer Sci
link: http://www.ncbi.nlm.nih.gov/pubmed/23648065
trait: Adverse response to chemotherapy (neutropenia/leucopenia) (5-fluorouracil)
initial_samplesize: 177 Japanese ancestry cases, 952 Japanese ancestry controls
region: 2q36.1
chrom: 2
reported_genes: SERPINE2
mapped_gene: SERPINE2 - FAM124B
upstream_gene_id: 5270
downstream_gene_id: 79843
strongest_risk_snp: rs6740660
strongest_risk_allele: G
snps: rs6740660
snp_id_current: 6740660
context: Intergenic
pvalue_mlog: 5.397940008672037
ci_95: [1.87-6.131]
platform: Illumina [733,202]
cnv: N
study:
Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.


dbdate: 2013-09-21
author: Cheong KA
date: 2013-05-02
journal: J Korean Med Sci
link: http://www.ncbi.nlm.nih.gov/pubmed/23678272
trait: Vitiligo (non-segmental)
initial_samplesize: 20 Korean ancestry cases, 192 Korean ancestry controls
replication_samplesize: 184 Korean ancestry cases, 192 Korean ancestry controls
region: 16q12.2
chrom: 16
reported_genes: KIAA1005
mapped_gene: RPGRIP1L
snp_gene_ids: 23322
strongest_risk_snp: rs3213758
strongest_risk_allele: A
snps: rs3213758
snp_id_current: 3213758
context: missense
pvalue_mlog: 10.22184874961635
ci_95: [2.04-3.76]
platform: Affymetrix [500,568]
cnv: N
study:
Three new single nucleotide polymorphisms identified by a genome-wide association study in Korean patients with vitiligo.


dbdate: 2013-11-16
author: Naj AC
date: 2013-05-01
journal: Ann Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23577725
trait: Age-related macular degeneration
initial_samplesize: 1,207 European ancestry cases, 686 European ancestry controls
replication_samplesize: 122 European ancestry cases, 86 European ancestry controls
region: 1q31.3
chrom: 1
reported_genes: CFH, CFHR4, CFHR5, KCNT2
mapped_gene: CFH
snp_gene_ids: 3075
strongest_risk_snp: rs1831282
snps: rs1831282
snp_id_current: 1831282
context: intron
pvalue_mlog: 31
ci_95: [2.08-2.78]
platform: Affymetrix [2,543,887] (Imputed)
cnv: N
study:
Genetic factors in nonsmokers with age-related macular degeneration revealed through genome-wide gene-environment interaction analysis.


dbdate: 2013-11-16
author: Naj AC
date: 2013-05-01
journal: Ann Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23577725
trait: Age-related macular degeneration (smoking status interaction)
region: 5p15.2
chrom: 5
reported_genes: Intergenic
mapped_gene: TAS2R1 - FAM173B
upstream_gene_id: 50834
downstream_gene_id: 134145
strongest_risk_snp: rs553169
strongest_risk_allele: A
snps: rs553169
snp_id_current: 553169
context: Intergenic
pvalue_mlog: 5.045757490560675
platform: Affymetrix [2,543,887] (Imputed)
cnv: N
initial_samplesize:
548 European ancestry ever smoking cases, 278 European ancestry ever smoking controls, 346 European ancestry never smoking cases, 247 European ancestry never smoking controls


dbdate: 2013-09-18
author: Tanaka T
date: 2013-05-01
journal: Am J Clin Nutr
link: http://www.ncbi.nlm.nih.gov/pubmed/23636237
trait: Dietary macronutrient intake
initial_samplesize: 37,537 European ancestry individuals
replication_samplesize: 33,533 European ancestry individuals
region: 8p23.2
chrom: 8
mapped_gene: RPL23AP54 - MCPH1
upstream_gene_id: 100271466
downstream_gene_id: 79648
strongest_risk_snp: rs2840445
strongest_risk_allele: A
snps: rs2840445
snp_id_current: 2840445
context: Intergenic
pvalue_mlog: 5.301029995663981
ci_95: [0.12-0.32] % decrease
platform: Illumina & Affymetrix [2.5 million] (Imputed)
cnv: N
study:
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake.


dbdate: 2013-09-16
author: Rinella ES
date: 2013-04-30
journal: J Clin Endocrinol Metab
link: http://www.ncbi.nlm.nih.gov/pubmed/23633212
trait: Weight loss (gastric bypass surgery)
initial_samplesize: 86 European ancestry individuals with least EBWL, 89 European ancestry individuals with most EBWL
replication_samplesize: 164 European ancestry individuals with least EBWL, 169 European ancestry individuals with most EBWL
region: 6p12.3
chrom: 6
reported_genes: PKHD1
mapped_gene: PKHD1
snp_gene_ids: 5314
strongest_risk_snp: rs728996
snps: rs728996
snp_id_current: 728996
context: intron
pvalue_mlog: 6.30102999566398
ci_95: [NR]
platform: Affymetrix [730,767]
cnv: N
study:
Genome-wide association of single-nucleotide polymorphisms with weight loss outcomes after Roux-en-Y gastric bypass surgery.


dbdate: 2013-09-14
author: Sulkava S
date: 2013-04-29
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23620144
trait: Job-related exhaustion
initial_samplesize: 1,256 European ancestry individuals
replication_samplesize: 13,864 European ancestry individuals
region: 6q25.1
chrom: 6
reported_genes: UST
mapped_gene: UST
snp_gene_ids: 10090
strongest_risk_snp: rs13219957
strongest_risk_allele: A
snps: rs13219957
snp_id_current: 13219957
context: intron
pvalue_mlog: 6.154901959985743
ci_95: [0.050-0.112] unit increase
platform: Illumina [555,388]
cnv: N
study:
Genome-wide scan of job-related exhaustion with three replication studies implicate a susceptibility variant at the UST gene locus.


dbdate: 2013-09-14
author: Zhao SX
date: 2013-04-29
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23612905
trait: Graves' disease
initial_samplesize: 1,442 Han Chinese ancestry cases, 1,468 Han Chinese ancestry controls
replication_samplesize: 7,891 Han Chinese ancestry cases, 8,351 Han Chinese ancestry controls
region: 1q23.2
chrom: 1
reported_genes: SLAMF6
mapped_gene: SLAMF6
snp_gene_ids: 114836
strongest_risk_snp: rs1265883
strongest_risk_allele: C
snps: rs1265883
snp_id_current: 1265883
context: intron
pvalue_mlog: 17.69897000433602
ci_95: [1.25-1.43]
platform: Illumina [8,019,905] (Imputed)
cnv: N
study:
Robust evidence for five new Graves' disease risk loci from a staged genome-wide association analysis.


dbdate: 2013-09-12
author: Deng M
date: 2013-04-28
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23624525
trait: Amyotrophic lateral sclerosis
initial_samplesize: 506 Han Chinese ancestry cases, 1,859 Han Chinese ancestry controls
replication_samplesize: 706 Han Chinese ancestry cases, 1,777 Han Chinese ancestry controls
region: 1q32.2
chrom: 1
reported_genes: CAMK1G
mapped_gene: MIR205 - CAMK1G
upstream_gene_id: 406988
downstream_gene_id: 57172
strongest_risk_snp: rs6703183
strongest_risk_allele: A
snps: rs6703183
snp_id_current: 6703183
context: Intergenic
pvalue_mlog: 7.522878745280337
ci_95: [NR]
platform: Illumina [473,683]
cnv: N
study:
Genome-wide association analyses in Han Chinese identify two new susceptibility loci for amyotrophic lateral sclerosis.


dbdate: 2013-09-10
author: Reiner AP
date: 2013-04-24
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23620142
trait: Circulating myeloperoxidase levels (plasma)
initial_samplesize: 9,260 European ancestry individuals
region: 17q22
chrom: 17
reported_genes: C17orf71
mapped_gene: SMG8
snp_gene_ids: 55181
strongest_risk_snp: rs6503905
strongest_risk_allele: A
snps: rs6503905
snp_id_current: 6503905
context: cds-synon
pvalue_mlog: 11.52287874528034
ci_95: [0.040-0.080] unit decrease
platform: Illumina & Affymetrix [2,421,770]
cnv: N
study:
Genome-wide and gene-centric analyses of circulating myeloperoxidase levels in the charge and care consortia.


dbdate: 2013-09-07
author: Cox AJ
date: 2013-04-19
journal: Atherosclerosis
link: http://www.ncbi.nlm.nih.gov/pubmed/23642732
trait: Bilirubin levels
initial_samplesize: 1,180 European ancestry individuals from ~475 families
region: 2q37.1
chrom: 2
reported_genes: UGT1A
mapped_gene: UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A1;UGT1A3
snp_gene_ids: 54575;54576;54577;54578;54579;54600;54657;54658;54659
strongest_risk_snp: rs887829
strongest_risk_allele: T
snps: rs887829
snp_id_current: 887829
context: intron;intron;intron;intron;intron;intron;intron;nearGene-5;intron
pvalue_mlog: 19.04575749056067
platform: Illumina & Affymetrix [371,951]
cnv: N
study:
Association of SNPs in the UGT1A gene cluster with total bilirubin and mortality in the Diabetes Heart Study.


dbdate: 2014-08-06
author: Noth I
date: 2013-04-17
journal: Lancet Respir Med
link: http://www.ncbi.nlm.nih.gov/pubmed/24429156
trait: Idiopathic pulmonary fibrosis
initial_samplesize: 542 European ancestry patients, 542 European ancestry controls
replication_samplesize: 868 European ancestry patients, 1,389 European ancestry controls
region: 11p15.5
chrom: 11
reported_genes: MUC5B, MUC5AC, TOLLIP
mapped_gene: MUC5AC - MUC5B
upstream_gene_id: 4586
downstream_gene_id: 727897
strongest_risk_snp: rs35705950
strongest_risk_allele: T
snps: rs35705950
snp_id_current: 35705950
context: Intergenic
pvalue_mlog: 49.69897000433602
ci_95: [2.13-2.77]
platform: Affymetrix [10,601,812] (imputed)
cnv: N
study:
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.


dbdate: 2013-08-23
author: Monda KL
date: 2013-04-14
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23583978
trait: Body mass index
initial_samplesize: 37,956 African American individuals, 1,188 Nigerian ancestry individuals
region: 1q25.2
chrom: 1
reported_genes: SEC16B
mapped_gene: BRINP2 - SEC16B
upstream_gene_id: 57795
downstream_gene_id: 89866
strongest_risk_snp: rs543874
strongest_risk_allele: G
snps: rs543874
snp_id_current: 543874
context: Intergenic
pvalue_mlog: 12.69897000433602
ci_95: [0.044-0.076] unit increase
platform: Illumina and Affymetrix [3,283,202] (Imputed)
cnv: N
study:
A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry.

replication_samplesize:
27,661 African America/Afro-Caribbean individuals, 4,607 Sub-Saharan African ancestry individuals, 123,706 European ancestry inidividuals


dbdate: 2013-08-20
author: den Hoed M
date: 2013-04-14
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23583979
trait: Heart rate
initial_samplesize: 85,787 European ancestry individuals, 6,568 Indian Asian ancestry indiviudals
replication_samplesize: 88,823 European ancestry individuals
region: 14q11.2
chrom: 14
reported_genes: MYH6
mapped_gene: MYH6
snp_gene_ids: 4624
strongest_risk_snp: rs365990
strongest_risk_allele: G
snps: rs365990
snp_id_current: 365990
context: missense
pvalue_mlog: 44.30102999566397
ci_95: [0.47-0.66] unit increase
platform: Illumina and Affymetrix [2,516,789] (Imputed)
cnv: N
study:
Identification of heart rate-associated loci and their effects on cardiac conduction and rhythm disorders.


dbdate: 2013-08-23
author: Go MJ
date: 2013-04-11
journal: J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23575436
trait: Glycemic traits
initial_samplesize: 7,696 Korean ancestry individuals
replication_samplesize: 6,536 Korean ancestry individuals
region: 7p13
chrom: 7
reported_genes: GCK
mapped_gene: GCK
snp_gene_ids: 2645
strongest_risk_snp: rs1799884
strongest_risk_allele: A
snps: rs1799884
snp_id_current: 1799884
context: nearGene-5
pvalue_mlog: 17.30102999566398
ci_95: [0.049-0.077] mmol-1 increase
platform: Affymetrix [357,789]
cnv: N
study:
New susceptibility loci in MYL2, C12orf51 and OAS1 associated with 1-h plasma glucose as predisposing risk factors for type 2 diabetes in the Korean population.


dbdate: 2013-08-13
author: Kirin M
date: 2013-04-11
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23585552
trait: Rhegmatogenous retinal detachment
initial_samplesize: 867 European ancestry cases, 1,953 European ancestry controls
replication_samplesize: 1,966 European ancestry cases, 5,918 European ancestry controls
region: 1q21.3
chrom: 1
reported_genes: CERS2,SETBD1,CTSS,MCL1,ANXA9,PRUNE,ARNT,GOLPH3L, CTSK, FAM63A,HORMAD1,ADAMTSL4,ENSA
mapped_gene: CERS2
snp_gene_ids: 29956
strongest_risk_snp: rs267738
strongest_risk_allele: A
snps: rs267738
snp_id_current: 267738
context: missense
pvalue_mlog: 7
ci_95: [1.14-1.33]
platform: Illumina [299,737]
cnv: N
study:
Genome-wide association study identifies genetic risk underlying primary rhegmatogenous retinal detachment.


dbdate: 2013-08-24
author: Reitz C
date: 2013-04-10
journal: JAMA
link: http://www.ncbi.nlm.nih.gov/pubmed/23571587
trait: Alzheimer's disease (late onset)
initial_samplesize: 1,968 African American cases, 3,928 African American controls
region: 19p13.3
chrom: 19
reported_genes: ABCA7, HMHA1, GRIN3B
mapped_gene: ABCA7
snp_gene_ids: 10347
strongest_risk_snp: rs115550680
strongest_risk_allele: G
snps: rs115550680
snp_id_current: 115550680
context: intron
pvalue_mlog: 8.698970004336019
ci_95: [1.47-2.12]
platform: Illumina [17,332,474] (Imputed)
cnv: N
study:
Variants in the ATP-binding cassette transporter (ABCA7), apolipoprotein E &#x003f5;4,and the risk of late-onset Alzheimer disease in African Americans.


dbdate: 2013-08-17
author: Urbanek M
date: 2013-04-10
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23575227
trait: Adiposity in newborns
replication_samplesize: 2,296 European ancestry individuals
region: 3q25.31
chrom: 3
reported_genes: LEKR1, CCNL1
mapped_gene: KLF3P2 - LINC00880
upstream_gene_id: 100124394
downstream_gene_id: 339894
strongest_risk_snp: rs1482853
strongest_risk_allele: C
snps: rs1482853
snp_id_current: 1482853
context: Intergenic
pvalue_mlog: 20.22184874961635
ci_95: [0.036-0.076] mm increase
platform: Illumina [565,808] (Imputed)
cnv: N
study:
The chromosome 3q25 genomic region is associated with measures of adiposity in newborns in a multi-ethnic genome-wide association study.

initial_samplesize:
1,095 Afro-Caribbean ancestry individuals, 1,363 European ancestry individuals, 616 Mexican American individuals, 1,207 Thai ancestry individuals


dbdate: 2013-08-07
author: Zheng HF
date: 2013-04-09
journal: J Med Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23572186
trait: Bone mineral density
initial_samplesize: 5,866 European ancestry individuals
replication_samplesize: 715 Mexican American individuals
region: 5q14.3
chrom: 5
reported_genes: MEF2C
mapped_gene: MEF2C
snp_gene_ids: 4208
strongest_risk_snp: rs11951031
strongest_risk_allele: T
snps: rs11951031
snp_id_current: 11951031
context: intron
pvalue_mlog: 8.045757490560675
ci_95: [0.12-0.28] unit decrease
platform: Illumina [NR] (imputed)
cnv: N
study:
Meta-analysis of genome-wide studies identifies MEF2C SNPs associated with bone mineral density at forearm.


dbdate: 2013-09-12
author: Berndt SI
date: 2013-04-07
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23563607
trait: Body mass index
region: 16q12.2
chrom: 16
reported_genes: FTO
mapped_gene: FTO
snp_gene_ids: 79068
strongest_risk_snp: rs11075990
strongest_risk_allele: G
snps: rs11075990
snp_id_current: 11075990
context: intron
pvalue_mlog: 50.69897000433601
ci_95: [NR]
platform: Illumina & Affymetrix [~2.8 millions] (Imputed)
cnv: N
study:
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.

initial_samplesize:
7,962 European ancestry individuals with high body mass index, 8,106 European ancestry individuals with low body mass index

replication_samplesize:
4,900 European ancestry individuals with high body mass index, 4,891 European ancestry individuals with low body mass index


dbdate: 2013-09-12
author: Berndt SI
date: 2013-04-07
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23563607
trait: Obesity
region: 13q32.1
chrom: 13
reported_genes: HS6ST3
mapped_gene: HS6ST3
snp_gene_ids: 266722
strongest_risk_snp: rs7989336
strongest_risk_allele: A
snps: rs7989336
snp_id_current: 7989336
context: intron
pvalue_mlog: 8
ci_95: [NR]
platform: Illumina & Affymetrix [~2.8 millions] (Imputed)
cnv: N
initial_samplesize:
93,015 European ancestry overweight individuals, 32,858 European ancestry individuals with class I obesity, 9,889 European ancestry individuals with class II obesity, 2,896 European ancestry individuals with class III obesity, up to 65,840 European ancestry controls

replication_samplesize:
65,332 European ancestry overweight individuals, 22,373 European ancestry individuals with class I obesity, 5,476 European ancestry individuals with class II obesity, 1,162 European ancestry individuals with class III obesity, up to 39,294 European ancestry controls


dbdate: 2013-09-12
author: Berndt SI
date: 2013-04-07
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23563607
trait: Waist-hip ratio
region: 6p25.1
chrom: 6
reported_genes: LY86
mapped_gene: LY86 - BTF3P7
upstream_gene_id: 9450
downstream_gene_id: 652960
strongest_risk_snp: rs1294421
strongest_risk_allele: G
snps: rs1294421
snp_id_current: 1294421
context: Intergenic
pvalue_mlog: 9.698970004336017
ci_95: [NR]
platform: Illumina & Affymetrix [~2.8 millions] (Imputed)
cnv: N
initial_samplesize:
4,774 European ancestry individuals with high waist-to-hip ratio, 5,481 European ancestry individuals with low waist-to-hip ratio

replication_samplesize:
3,351 European ancestry individuals with high waist-to-hip ratio, 3,352 European ancestry individuals with low waist-to-hip ratio


dbdate: 2013-10-24
author: Wheeler E
date: 2013-04-07
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23563609
trait: Obesity (early onset extreme)
initial_samplesize: 1,509 European ancestry cases, 5,380 European ancestry controls
replication_samplesize: 971 European ancestry cases, 1,990 European ancestry controls
region: 16q12.2
chrom: 16
reported_genes: FTO
mapped_gene: FTO
snp_gene_ids: 79068
strongest_risk_snp: rs1421085
strongest_risk_allele: C
snps: rs1421085
snp_id_current: 1421085
context: intron
pvalue_mlog: 27.52287874528033
ci_95: [1.35-1.54]
platform: Affymetrix [~2 million] (Imputed)
cnv: N
study:
Genome-wide SNP and CNV analysis identifies common and low-frequency variants associated with severe early-onset obesity.


dbdate: 2013-09-24
author: Ran S
date: 2013-04-04
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/23593202
trait: Femoral neck bone geometry and menarche (age at onset)
initial_samplesize: 1,728 European ancestry individuals
replication_samplesize: 501 European ancestry individuals, 826 Chinese ancestry individuals
region: 19q12
chrom: 19
reported_genes: LOC148145
mapped_gene: LOC100420587;LOC101927210
snp_gene_ids: 100420587;101927210
strongest_risk_snp: rs4141232
snps: rs4141232
snp_id_current: 4141232
context: intron;intron
pvalue_mlog: 6.698970004336019
platform: Affymetrix [760,794]
cnv: N
study:
Bivariate genome-wide association analyses identified genes with pleiotropic effects for femoral neck bone geometry and age at menarche.


dbdate: 2013-07-12
author: Miyashita A
date: 2013-04-02
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/23565137
trait: Alzheimer's disease (late onset)
initial_samplesize: 891 Japanese ancestry cases, 844 Japanese ancestry controls
region: 11q24.1
chrom: 11
reported_genes: SORL1
mapped_gene: SORL1
snp_gene_ids: 6653
strongest_risk_snp: rs11218343
snps: rs11218343
snp_id_current: 11218343
context: intron
pvalue_mlog: 8.698970004336019
ci_95: [1.15-1.33]
platform: Affymetrix [5,877,918] (Imputed)
cnv: N
study:
SORL1 is genetically associated with late-onset Alzheimer's disease in Japanese, Koreans and Caucasians.

replication_samplesize:
1,224 East Asian ancestry cases, 2,114 East Asian ancestry controls, 11,840 European ancestry cases, 10,931 European ancestry controls


dbdate: 2013-09-27
author: Zhao L
date: 2013-04-02
journal: Ann Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23551011
trait: Preeclampsia
region: 13q33.1
chrom: 13
reported_genes: FGF14
mapped_gene: FGF14
snp_gene_ids: 2259
strongest_risk_snp: rs11617740
snps: rs11617740
snp_id_current: 11617740
context: intron
pvalue_mlog: 6.154901959985743
ci_95: [5.53-51.97]
platform: Illumina [2,485,249] (Imputed)
cnv: N
study:
Genome-Wide Association Study of Pre-Eclampsia Detects Novel Maternal Single Nucleotide Polymorphisms and Copy-Number Variants in Subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study Cohort.

initial_samplesize:
21 Afro-Caribbean ancestry cases, 1,010 Afro-Caribbean ancestry controls, 50 European ancestry cases, 1,202 European ancestry controls, 62 Hispanic cases, 658 Hispanic controls


dbdate: 2013-09-27
author: Ebejer JL
date: 2013-04-01
journal: Twin Res Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23527680
trait: Attention deficit hyperactivity disorder (combined symptoms)
initial_samplesize: 1,851 individuals
replication_samplesize: 155 individuals
region: 20q13.13
chrom: 20
mapped_gene: LINC00494 - PREX1
upstream_gene_id: 284749
downstream_gene_id: 57580
strongest_risk_snp: rs910191
strongest_risk_allele: A
snps: rs910191
snp_id_current: 910191
context: Intergenic
pvalue_mlog: 5.698970004336018
platform: Illumina [2,373,249] (Imputed)
cnv: N
study:
Genome-wide association study of inattention and hyperactivity-impulsivity measured as quantitative traits.


dbdate: 2013-09-16
author: Eeles RA
date: 2013-04-01
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23535732
trait: Prostate cancer
initial_samplesize: 11,085 European ancestry cases, 11,463 European ancestry controls
replication_samplesize: 19,662 European ancestry cases, 19,715 European ancestry controls
region: 1q21.3
chrom: 1
mapped_gene: KCNN3
snp_gene_ids: 3782
strongest_risk_snp: rs1218582
strongest_risk_allele: G
snps: rs1218582
snp_id_current: 1218582
context: intron
pvalue_mlog: 7.698970004336018
ci_95: [1.03-1.09]
platform: Illumina [~2.6 million] (Imputed)
cnv: N
study:
Identification of 23 new prostate cancer susceptibility loci using the iCOGS custom genotyping array.

reported_genes:
ADAM15, ADAR, CKS1B, DCST1, DCST2, DPM3, EFNA1, EFNA3,EFNA4, FLAD1, KCNN3, LENEP, LOC10050, LOC100505666,MIR4258, PBXIP1, PMVK, PYGO2, SHC1, SLC50A1, ZBTB7B


dbdate: 2013-09-16
author: Eeles RA
date: 2013-04-01
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23535732
trait: Prostate cancer
initial_samplesize: 11,085 European ancestry cases, 11,463 European ancestry controls
replication_samplesize: 19,662 European ancestry cases, 19,715 European ancestry controls
region: 6p21.32
chrom: 6
mapped_gene: NOTCH4
snp_gene_ids: 4855
strongest_risk_snp: rs3096702
strongest_risk_allele: A
snps: rs3096702
snp_id_current: 3096702
context: nearGene-5
pvalue_mlog: 8.301029995663981
ci_95: [1.04-1.10]
platform: Illumina [~2.6 million] (Imputed)
cnv: N
reported_genes:
AGER, AGPAT1, ATF6B, BTNL2, C2, C4A, C4B, C6orf10, CFB,CYP21A1P, CYP21A2, DOM3Z, EGFL8, FKBPL, GPSM3,HCG23, HLA-DQA1, HLA-DQB1, HLA-DRA, HLA-DRB1, HLA-DRB5,HLA-DRB6, LOC10029, LOC100293534, LOC10050,LOC100507547, MIR1236, NOTCH4, PBX2, PPT2, PPT2-EGF,PPT2-EGFL8, PRRT1, RDBP, RNF5, RNF5P1, SKIV2L, STK19,TNXA, TNXB


dbdate: 2013-09-16
author: Eeles RA
date: 2013-04-01
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23535732
trait: Prostate cancer
initial_samplesize: 11,085 European ancestry cases, 11,463 European ancestry controls
replication_samplesize: 19,662 European ancestry cases, 19,715 European ancestry controls
region: 10q24.32
chrom: 10
mapped_gene: TRIM8
snp_gene_ids: 81603
strongest_risk_snp: rs3850699
strongest_risk_allele: A
snps: rs3850699
snp_id_current: 3850699
context: intron
pvalue_mlog: 9.301029995663981
ci_95: [1.06-1.12]
platform: Illumina [~2.6 million] (Imputed)
cnv: N
reported_genes:
ACTR1A, ARL3, AS3MT, C10orf32, C10orf32-AS3MT, C10orf95,CNNM2, CUEDC2, CYP17A1, FBXL15, LOC100505761,MIR146B, PSD, SFXN2, SUFU, TMEM180, TRIM8, WBP1L


dbdate: 2013-09-16
author: Eeles RA
date: 2013-04-01
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23535732
trait: Prostate cancer
initial_samplesize: 11,085 European ancestry cases, 11,463 European ancestry controls
replication_samplesize: 19,662 European ancestry cases, 19,715 European ancestry controls
region: 20q13.33
chrom: 20
mapped_gene: RBBP8NL - GATA5
upstream_gene_id: 140893
downstream_gene_id: 140628
strongest_risk_snp: rs2427345
strongest_risk_allele: G
snps: rs2427345
snp_id_current: 2427345
context: Intergenic
pvalue_mlog: 7.397940008672037
ci_95: [1.03-1.1]
platform: Illumina [~2.6 million] (Imputed)
cnv: N
reported_genes:
ADRM1, C20orf15, C20orf151, C20orf166, C20orf166-AS1,CABLES2, GATA5, GTPBP5, HRH3, LAMA5, MIR1-1,MIR133A2, MIR4758, OSBPL2, RPS21


dbdate: 2013-09-16
author: Eeles RA
date: 2013-04-01
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23535732
trait: Prostate cancer
initial_samplesize: 11,085 European ancestry cases, 11,463 European ancestry controls
replication_samplesize: 19,662 European ancestry cases, 19,715 European ancestry controls
region: 20q13.33
chrom: 20
mapped_gene: ZGPAT
snp_gene_ids: 84619
strongest_risk_snp: rs6062509
strongest_risk_allele: A
snps: rs6062509
snp_id_current: 6062509
context: intron
pvalue_mlog: 15.39794000867204
ci_95: [1.09-1.16]
platform: Illumina [~2.6 million] (Imputed)
cnv: N
reported_genes:
ABHD16B, ARFRP1, C20orf195, DNAJC5, EEF1A2, GMEB2,LIME1, LOC100505815, MIR1914, MIR647, MIR941-1,MIR941-2, MIR941-3, MIR941-4, PPDPF, PRIC285, PRPF6,PTK6, RTEL1, RTEL1-TN, RTEL1-TNFRSF6B, SAMD10,SLC2A4RG, SRMS, STMN3, TNFRSF6B, TPD52L2, UCKL1,UCKL1-AS1, ZBTB46, ZGPAT, ZNF512B


dbdate: 2013-10-30
author: Melen E
date: 2013-04-01
journal: Clin Exp Allergy
link: http://www.ncbi.nlm.nih.gov/pubmed/23517042
study: Genome-wide association study of body mass index in 23 000 individuals with and without asthma.
trait: Body mass index (asthmatics)
replication_samplesize: 979 European ancestry children, 921 Hispanic children, 120 Other ancestry children
region: 18p11.31
chrom: 18
reported_genes: LPIN2
mapped_gene: LPIN2;LOC727896
snp_gene_ids: 9663;727896
strongest_risk_snp: rs643507
strongest_risk_allele: C
snps: rs643507
snp_id_current: 643507
context: intron;ncRNA
pvalue_mlog: 8.096910013008056
platform: Illumina [536,451]
cnv: N
initial_samplesize:
1,881 European ancestry children, 109 European and other ancestry children, 701 Other ancestry children


dbdate: 2013-10-30
author: Melen E
date: 2013-04-01
journal: Clin Exp Allergy
link: http://www.ncbi.nlm.nih.gov/pubmed/23517042
study: Genome-wide association study of body mass index in 23 000 individuals with and without asthma.
trait: Body mass index (non-asthmatics)
replication_samplesize: 841 European ancestry children, 421 Hispanic children, 381 Other ancestry children
region: 9q33.3
chrom: 9
reported_genes: DENND1A
mapped_gene: DENND1A
snp_gene_ids: 57706
strongest_risk_snp: rs10818854
strongest_risk_allele: A
snps: rs10818854
snp_id_current: 10818854
context: intron
pvalue_mlog: 6.698970004336019
platform: Illumina [536,451]
cnv: N
initial_samplesize:
5,184 European ancestry children, 186 Other ancestry children, 7,861 European ancestry adults, 331 European and other ancestry adults, 192 Other ancestry adults


dbdate: 2013-07-12
author: Pharoah PD
date: 2013-04-01
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23535730
study: GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
trait: Ovarian cancer
initial_samplesize: 3,769 European ancestry cases, 4,396 European ancestry controls
region: 9p22.2
chrom: 9
mapped_gene: LSM1P1 - RPL31P42
upstream_gene_id: 100820732
downstream_gene_id: 100271197
strongest_risk_snp: rs3814113
snps: rs3814113
snp_id_current: 3814113
context: Intergenic
pvalue_mlog: 28.39794000867204
ci_95: [1.17-1.25]
platform: Illumina [2,508,744] (Imputed)
cnv: N
replication_samplesize:
211 East Asian cases, 972 East Asian controls, 39,674 European ancestry individuals, 106 Malaysian cases, 106 Malaysian controls


dbdate: 2013-07-12
author: Pharoah PD
date: 2013-04-01
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23535730
study: GWAS meta-analysis and replication identifies three new susceptibility loci for ovarian cancer.
trait: Ovarian cancer
initial_samplesize: 3,769 European ancestry cases, 4,396 European ancestry controls
region: 17q12
chrom: 17
mapped_gene: HNF1B
snp_gene_ids: 6928
strongest_risk_snp: rs757210
strongest_risk_allele: G
snps: rs757210
snp_id_current: 757210
context: intron
pvalue_mlog: 9.096910013008054
ci_95: [1.08-1.17]
platform: Illumina [2,508,744] (Imputed)
cnv: N
reported_genes:
HNF1B, ACACA, C17orf78, TADA2A, DUSP14, SYNRG, DDX52, TBC1D3F, TBC1D3, MRPL45, GPR179, SOCS7, ARHGAP23


dbdate: 2013-07-27
author: Yang SK
date: 2013-04-01
journal: Inflamm Bowel Dis
link: http://www.ncbi.nlm.nih.gov/pubmed/23511034
trait: Ulcerative colitis
initial_samplesize: 388 Korean ancestry cases, 739 Korean ancestry controls
replication_samplesize: 810 Korean ancestry cases, 1709 Korean ancestry controls
region: 13q12.13
chrom: 13
reported_genes: Intergenic
mapped_gene: FGFR1OP2P1 - RPS21P8
upstream_gene_id: 100873883
downstream_gene_id: 100873798
strongest_risk_snp: rs17085007
strongest_risk_allele: C
snps: rs17085007
snp_id_current: 17085007
context: Intergenic
pvalue_mlog: 6.522878745280337
ci_95: [1.22-1.55]
platform: Illumina [581,060]
cnv: N
study:
Genome-wide association study of ulcerative colitis in Koreans suggests extensive overlapping of genetic susceptibility with Caucasians.


dbdate: 2013-08-10
author: Zhang M
date: 2013-04-01
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23548203
trait: Eye color
initial_samplesize: 3871 European ancestry individuals
replication_samplesize: 2,496 European ancestry individuals
region: 1q32.3
chrom: 1
reported_genes: VASH2
mapped_gene: VASH2
snp_gene_ids: 79805
strongest_risk_snp: rs3002288
strongest_risk_allele: A
snps: rs3002288
snp_id_current: 3002288
context: intron
pvalue_mlog: 7.154901959985742
ci_95: [0.14-0.30] unit decrease
platform: Illumina & Affymetrix [2,469,762] (Imputed)
cnv: N
study:
Genome-wide association studies identify several new loci associated with pigmentation traits and skin cancer risk in European Americans.


dbdate: 2013-07-25
author: Cui J
date: 2013-03-28
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23555300
trait: Response to anti-TNF treatment in rheumatoid arthritis
initial_samplesize: Up to 2,706 European ancestry cases
region: 10p14
chrom: 10
mapped_gene: PRKCQ-AS1 - LINC00706
upstream_gene_id: 439949
downstream_gene_id: 100652997
strongest_risk_snp: rs12570744
strongest_risk_allele: T
snps: rs12570744
snp_id_current: 12570744
context: Intergenic
pvalue_mlog: 6.698970004336019
ci_95: [NR] unit decrease
platform: Illumina and Affymetrix [~ 2 Million] (Imputed)
cnv: N
study:
Genome-wide association study and gene expression analysis identifies CD84 as a predictor of response to etanercept therapy in rheumatoid arthritis.


dbdate: 2013-07-31
author: Jeff JM
date: 2013-03-28
journal: Ann Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23534349
trait: Heart rate
initial_samplesize: 455 African American individuals
region: 8p11.23
chrom: 8
reported_genes: Intergenic
mapped_gene: SMARCE1P4 - ZNF703
upstream_gene_id: 642879
downstream_gene_id: 80139
strongest_risk_snp: rs1015003
strongest_risk_allele: G
snps: rs1015003
snp_id_current: 1015003
context: Intergenic
pvalue_mlog: 5.999999999999999
ci_95: [NR] ms increase
platform: Illumina [>930,000]
cnv: N
study:
Generalization of variants identified by genome-wide association studies for electrocardiographic traits in african americans.


dbdate: 2013-07-05
author: Kitamoto T
date: 2013-03-28
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23535911
trait: Non-alcoholic fatty liver disease
initial_samplesize: 392 Japanese ancestry cases, 934 Japanese ancestry controls
replication_samplesize: 172 Japanese ancestry cases, 1,012 Japanese ancestry controls
region: 1p35.2
chrom: 1
reported_genes: PTPRU
mapped_gene: PTPRU - MATN1
upstream_gene_id: 10076
downstream_gene_id: 4146
strongest_risk_snp: rs6691847
strongest_risk_allele: C
snps: rs6691847
snp_id_current: 6691847
context: Intergenic
pvalue_mlog: 5.154901959985742
ci_95: [0.98-1.77]
platform: Illumina [261,540]
cnv: N
study:
Genome-wide scan revealed that polymorphisms in the PNPLA3, SAMM50, and PARVB genes are associated with development and progression of nonalcoholic fatty liver disease in Japan.


dbdate: 2013-07-05
author: Tin A
date: 2013-03-28
journal: J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23535967
trait: Glomerular filtration rate
initial_samplesize: 9,049 European ancestry individuals
region: 2p13.1
chrom: 2
reported_genes: NAT8
mapped_gene: ALMS1P
snp_gene_ids: 200420
strongest_risk_snp: rs10206899
strongest_risk_allele: C
snps: rs10206899
snp_id_current: 10206899
context: intron
pvalue_mlog: 7.397940008672037
ci_95: [0.76-1.58] unit increase
platform: Affymetrix [>2.5 million] imputed
cnv: N
study:
Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate.


dbdate: 2013-08-02
author: Couch FJ
date: 2013-03-27
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23544013
trait: Breast Cancer in BRCA1 mutation carriers
initial_samplesize: 1,426 European ancestry cases, 1,301 European ancestry controls
replication_samplesize: 6,031 European ancestry cases, 5,933 European ancestry controls
region: 1q32.1
chrom: 1
reported_genes: MDM4
mapped_gene: MDM4
snp_gene_ids: 4194
strongest_risk_snp: rs2290854
strongest_risk_allele: A
snps: rs2290854
snp_id_current: 2290854
context: intron
pvalue_mlog: 7
ci_95: [1.08-1.18]
platform: Illumina [2,568,349] (Imputed)
cnv: N
study:
Genome-wide association study in BRCA1 mutation carriers identifies novel loci associated with breast and ovarian cancer risk.


dbdate: 2013-06-27
author: Li X
date: 2013-03-27
journal: J Allergy Clin Immunol
link: http://www.ncbi.nlm.nih.gov/pubmed/23541324
trait: Pulmonary function in asthmatics
initial_samplesize: 1,544 European ancestry individuals
region: 22q13.31
chrom: 22
reported_genes: UPK3A
mapped_gene: MIR1249 - RPS10P31
upstream_gene_id: 100302149
downstream_gene_id: 100129939
strongest_risk_snp: rs58667
strongest_risk_allele: A
snps: rs58667
snp_id_current: 58667
context: Intergenic
pvalue_mlog: 6.397940008672037
ci_95: [NR] unit increase
platform: Illumina [369,771]
cnv: N
study:
Genome-wide association study identifies TH1 pathway genes associated with lung function in asthmatic patients.


dbdate: 2013-06-26
author: Ma RC
date: 2013-03-27
journal: Diabetologia
link: http://www.ncbi.nlm.nih.gov/pubmed/23532257
trait: Type 2 diabetes
initial_samplesize: 684 Han Chinese ancestry cases, 955 Han Chinese ancestry controls
region: 7q32.1
chrom: 7
reported_genes: ARF5, PAX4, SND1
mapped_gene: FSCN3 - PAX4
upstream_gene_id: 29999
downstream_gene_id: 5078
strongest_risk_snp: rs10229583
strongest_risk_allele: G
snps: rs10229583
snp_id_current: 10229583
context: Intergenic
pvalue_mlog: 9.698970004336017
ci_95: [1.09-1.19]
platform: Illumina [2,925,090] (Imputed)
cnv: N
study:
Genome-wide association study in a Chinese population identifies a susceptibility locus for type 2 diabetes at 7q32 near PAX4.

replication_samplesize:
18,954 East Asian ancestry cases, 18,029 East Asian ancestry controls, 794 Singaporean Malay ancestry cases, 1,204 Singaporean Malay ancestry controls, 977 Singaporean Indian ancestry cases, 1,169 Singaporean Indian ancestry controls, 8,130 European ancestry cases, 38,987 European ancestry controls


dbdate: 2013-06-26
author: Liu M
date: 2013-03-21
journal: Mol Endocrinol
link: http://www.ncbi.nlm.nih.gov/pubmed/23518928
study: TSPYL5 SNPs: association with plasma estradiol concentrations and aromatase expression.
trait: Estradiol plasma levels (breast cancer)
region: 8q22.1
chrom: 8
reported_genes: TSPYL5
mapped_gene: LOC101927066
snp_gene_ids: 101927066
strongest_risk_snp: rs1864729
snps: rs1864729
snp_id_current: 1864729
context: intron
pvalue_mlog: 7.522878745280337
ci_95: [1.35-1.871] unit increase
platform: Illumina [563,945]
cnv: N
initial_samplesize:
700 European ancestry cases, 50 African ancestry cases, 17 Asian ancestry cases, 5 American Indian cases


dbdate: 2013-07-26
author: Xu H
date: 2013-03-19
journal: J Natl Cancer Inst
link: http://www.ncbi.nlm.nih.gov/pubmed/23512250
trait: Acute lymphoblastic leukemia (childhood)
region: 7p12.2
chrom: 7
reported_genes: IKZF1,DDC,GRB10
mapped_gene: IKZF1
snp_gene_ids: 10320
strongest_risk_snp: rs6964969
strongest_risk_allele: C
snps: rs6964969
snp_id_current: 6964969
context: nearGene-3
pvalue_mlog: 28.69897000433602
ci_95: [1.53-1.83]
platform: Affymetrix [709,059]
cnv: N
study:
Novel susceptibility variants at 10p12.31-12.2 for childhood acute lymphoblastic leukemia in ethnically diverse populations.

initial_samplesize:
972 European ancestry cases, 1,386 European ancestry controls, 89 African American cases, 1,363 African American controls, 305 Hispanic cases, 1,008 Hispanic controls

replication_samplesize:
574 European ancestry cases, 2,601 European ancestry controls, 128 African American cases, 1,075 African American controls, 143 Hispanic cases, 640 Hispanic controls


dbdate: 2013-06-20
author: Luca G
date: 2013-03-18
journal: J Sleep Res
link: http://www.ncbi.nlm.nih.gov/pubmed/23496005
trait: Narcolepsy with cataplexy
initial_samplesize: 585 European ancestry cases
replication_samplesize: 387 European ancestry cases
region: 19q12
chrom: 19
mapped_gene: RNA5SP471 - CTC-360P9.3
upstream_gene_id: 100873714
downstream_gene_id: 100996665
strongest_risk_snp: rs16966122
snps: rs16966122
snp_id_current: 16966122
context: Intergenic
pvalue_mlog: 5.698970004336018
ci_95: [NR] unit decrease
cnv: N
study:
Clinical, polysomnographic and genome-wide association analyses of narcolepsy with cataplexy: a European Narcolepsy Network study.


dbdate: 2013-07-01
author: Zhou G
date: 2013-03-18
journal: J Biol Chem
link: http://www.ncbi.nlm.nih.gov/pubmed/23508960
trait: Aspirin hydrolysis (plasma)
initial_samplesize: 2,054 European ancestry individuals
region: 3q26.1
chrom: 3
reported_genes: BCHE
mapped_gene: SLITRK3 - BCHE
upstream_gene_id: 22865
downstream_gene_id: 590
strongest_risk_snp: rs6445035
strongest_risk_allele: A
snps: rs6445035
snp_id_current: 6445035
context: Intergenic
pvalue_mlog: 16.04575749056067
platform: Affymetrix [2,421,779] (Imputed)
cnv: N
study:
Aspirin hydrolysis in plasma is a variable function of butyrylcholinesterase and platelet-activating factor acetylhydrolase 1b2 (PAFAH1b2).


dbdate: 2013-06-21
author: Germain M
date: 2013-03-17
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23502781
trait: Pulmonary arterial hypertension (without BMPR2 mutations)
initial_samplesize: 340 European ancestry cases, 1,068 European ancestry controls
replication_samplesize: 285 cases, 457 controls
region: 18q22.3
chrom: 18
reported_genes: CBLN2
mapped_gene: GTSCR1 - CBLN2
upstream_gene_id: 220158
downstream_gene_id: 147381
strongest_risk_snp: rs2217560
strongest_risk_allele: G
snps: rs2217560
snp_id_current: 2217560
context: Intergenic
pvalue_mlog: 9.154901959985741
ci_95: [1.59-2.45]
platform: Illumina [462,499]
cnv: N
study:
Genome-wide association analysis identifies a susceptibility locus for pulmonary arterial hypertension.


dbdate: 2013-06-18
author: van Setten J
date: 2013-03-13
journal: Atherosclerosis
link: http://www.ncbi.nlm.nih.gov/pubmed/23561647
trait: Coronary artery calcification
initial_samplesize: 2,620 European ancestry males
region: 9p21.3
chrom: 9
reported_genes: CDKN2A,CDKN2B
mapped_gene: CDKN2B-AS1
snp_gene_ids: 100048912
strongest_risk_snp: rs1537370
strongest_risk_allele: T
snps: rs1537370
snp_id_current: 1537370
context: intron
pvalue_mlog: 10.69897000433602
ci_95: [0.38-0.69] unit increase
platform: Illumina [2.5 Million] (Imputed)
cnv: N
study:
Genome-wide association study of coronary and aortic calcification implicates risk loci for coronary artery disease and myocardial infarction.


dbdate: 2013-07-01
author: Han JY
date: 2013-03-12
journal: Pharmacogenomics J
link: http://www.ncbi.nlm.nih.gov/pubmed/23478653
trait: Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer
initial_samplesize: 139 individuals
region: 1p31.3
chrom: 1
reported_genes: Intergenic
mapped_gene: SERBP1 - HNRNPCP9
upstream_gene_id: 26135
downstream_gene_id: 100130196
strongest_risk_snp: rs344924
snps: rs344924
snp_id_current: 344924
context: Intergenic
pvalue_mlog: 6.522878745280337
ci_95: [2.70-9.0]
platform: Affymetrix [334,127]
cnv: N
study:
A genome-wide association study of survival in small-cell lung cancer patients treated with irinotecan plus cisplatin chemotherapy.


dbdate: 2013-06-16
author: Stambolian D
date: 2013-03-07
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23474815
trait: Refractive error
initial_samplesize: 6,597 European ancestry individuals, 683 Sardinian inidividuals
replication_samplesize: 19,763 European ancestry individuals
region: 16p13.3
chrom: 16
reported_genes: RBFOX1
mapped_gene: RBFOX1
snp_gene_ids: 54715
strongest_risk_snp: rs10500355
snps: rs10500355
snp_id_current: 10500355
context: intron
pvalue_mlog: 8.397940008672036
ci_95: [0.074-0.147] unit decrease
platform: Illumina & Affymetrix [2,093,862] (Imputed)
cnv: N
study:
Meta-analysis of genome-wide association studies in five cohorts reveals common variants in RBFOX1, a regulator of tissue-specific splicing, associated with refractive error.


dbdate: 2013-06-21
author: Zeng Z
date: 2013-03-07
journal: J Dent Res
link: http://www.ncbi.nlm.nih.gov/pubmed/23470693
trait: Pit-and-Fissure caries
initial_samplesize: 996 European ancestry individuals
region: 6p25.3
chrom: 6
mapped_gene: EXOC2
snp_gene_ids: 55770
strongest_risk_snp: rs9504361
strongest_risk_allele: G
snps: rs9504361
snp_id_current: 9504361
context: intron
pvalue_mlog: 5.221848749616356
ci_95: [NR] unit increase
platform: Illumina [1.2 Million] (Imputed)
cnv: N
study:
Genome-wide association studies of pit-and-fissure- and smooth-surface caries in permanent dentition.


dbdate: 2013-06-28
author: Pare G
date: 2013-03-06
journal: Circulation
link: http://www.ncbi.nlm.nih.gov/pubmed/23467860
study: Genetic determinants of dabigatran plasma levels and their relation to bleeding.
trait: Response to dabigatran etexilate treatment
initial_samplesize: 1,490 European ancestry atrial fibrillation patients at risk of stroke
region: 16q12.2
chrom: 16
reported_genes: CES1
mapped_gene: CES1
snp_gene_ids: 1066
strongest_risk_snp: rs2244613
snps: rs2244613
snp_id_current: 2244613
context: intron
pvalue_mlog: 6.30102999566398
ci_95: [1.10-1.22]
platform: Illumina [551,203]
cnv: N
replication_samplesize:
204 European ancestry atrial fibrillation patients at risk of stroke, 66 Latin American ancestry atrial fibrillation patients at risk of stroke, 1 Arab ancestry atrial fibrillation patient at risk of stroke, 5 Black African atrial fibrillation patients at risk of stroke, 21 Chinese ancestry atrial fibrillation patients at risk of stroke, 1 Colored African atrial fibrillation patient at risk of stroke, 4 Japanese ancestry atrial fibrillation patients at risk of stroke, 9 South Asian ancestry atrial fibrillation patients at risk of stroke, 15 other Asian ancestry atrial fibrillation patients at risk of stroke and 134 atrial fibrillation patients at risk of stroke


dbdate: 2013-06-14
author: Avery CL
date: 2013-03-05
journal: Pharmacogenomics J
link: http://www.ncbi.nlm.nih.gov/pubmed/23459443
trait: QT interval (interaction)
initial_samplesize: 33,781 Euroepan ancestry individuals
region: 10p13
chrom: 10
reported_genes: CAMK1D
mapped_gene: CAMK1D
snp_gene_ids: 57118
strongest_risk_snp: rs10906189
strongest_risk_allele: A
snps: rs10906189
snp_id_current: 10906189
context: intron
pvalue_mlog: 5.221848749616356
platform: Illumina & Affymetrix [~2.5 Million] (imputed)
cnv: N
study:
Drug-gene interactions and the search for missing heritability: a cross-sectional pharmacogenomics study of the QT interval.


dbdate: 2013-06-18
author: Jahanshad N
date: 2013-03-05
journal: Proc Natl Acad Sci U S A
link: http://www.ncbi.nlm.nih.gov/pubmed/23471985
trait: Brain connectivity
initial_samplesize: 331 European ancestry individuals
region: 20p12.1
chrom: 20
reported_genes: MACROD2
mapped_gene: ENSAP1 - PPIAP17
upstream_gene_id: 170511
downstream_gene_id: 170540
strongest_risk_snp: rs16997087
snps: rs16997087
snp_id_current: 16997087
context: Intergenic
pvalue_mlog: 10
platform: Illumina [428,287]
cnv: N
study:
Genome-wide scan of healthy human connectome discovers SPON1 gene variant influencing dementia severity.


dbdate: 2013-06-13
author: Mero IL
date: 2013-03-05
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/23472185
trait: Multiple sclerosis (OCB status)
initial_samplesize: 1,367 European ancestry OCB positive cases, 161 European ancestry OCB negative cases
replication_samplesize: 3,029 European ancestry OCB positive cases, 374 European ancestry OCB negative cases
region: 3q23
chrom: 3
reported_genes: CLSTN2
mapped_gene: CLSTN2
snp_gene_ids: 64084
strongest_risk_snp: rs17411949
snps: rs17411949
snp_id_current: 17411949
context: intron
pvalue_mlog: 6.096910013008056
ci_95: [1.45-2.37]
platform: Illumina [495,970]
cnv: N
study:
Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles.


dbdate: 2013-06-13
author: Mero IL
date: 2013-03-05
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/23472185
trait: Multiple sclerosis (OCB status)
region: 1q23.2
chrom: 1
reported_genes: C10ORF204
mapped_gene: C1orf204
snp_gene_ids: 284677
strongest_risk_snp: rs6659742
snps: rs6659742
snp_id_current: 6659742
context: intron
pvalue_mlog: 6.154901959985743
ci_95: [1.52-2.61]
platform: Illumina [495,970]
cnv: N
initial_samplesize:
1,367 European ancestry OCB positive cases, 161 European ancestry OCB negative cases, 428 European ancestry controls


dbdate: 2013-04-11
author: Crosslin DR
date: 2013-03-03
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23314186
study: Genetic variation associated with circulating monocyte count in the eMERGE Network.
trait: Monocyte count
region: 2q31.3
chrom: 2
reported_genes: ITGA4
mapped_gene: ITGA4
snp_gene_ids: 3676
strongest_risk_snp: rs2124440
strongest_risk_allele: G
snps: rs2124440
snp_id_current: 2124440
context: intron
pvalue_mlog: 16.30102999566398
ci_95: [NR] unit decrease
platform: Illumina [NR]
cnv: N
initial_samplesize:
9,849 European ancestry individuals, 894 African ancestry individuals, 271 other ancestry individuals


dbdate: 2013-07-31
author: Fritsche LG
date: 2013-03-03
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23455636
study: Seven new loci associated with age-related macular degeneration.
trait: Age-related macular degeneration
region: 10q26.13
chrom: 10
reported_genes: ARMS2, HTRA1
mapped_gene: ARMS2
snp_gene_ids: 387715
strongest_risk_snp: rs10490924
strongest_risk_allele: T
snps: rs10490924
snp_id_current: 10490924
context: missense
pvalue_mlog: 539.3979400086721
ci_95: [2.72-2.80]
platform: Illumina & Affymetrix [2,442,884] (Imputed)
cnv: N
initial_samplesize:
6,713 European ancestry cases, 48,402 European ancestry contols, 110 Southern Indian ancestry cases, 119 Southern Indian ancestry controls, 827 Japanese ancestry cases, 3,323 Japanese ancestry controls

replication_samplesize:
9,070 European ancestry cases, 7,683 European ancestry contols, 461 East Asian ancestry cases, 547 East Asian ancestry controls


dbdate: 2013-06-18
author: Park BL
date: 2013-03-01
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23456092
trait: Alcohol dependence
initial_samplesize: 117 Korean ancestry cases, 279 Korean ancestry controls
replication_samplesize: 504 Korean ancestry cases, 471 Korean ancestry controls
region: 4q23
chrom: 4
reported_genes: ADH5, ADH4, ADH6, ADH1A, ADH7, ADH1B, ADH1C
mapped_gene: ADH1B
snp_gene_ids: 125
strongest_risk_snp: rs1229984
snps: rs1229984
snp_id_current: 1229984
context: missense
pvalue_mlog: 20.52287874528034
ci_95: [1.95-2.84]
platform: Illumina [427,349]
cnv: N
study:
Extended genetic effects of ADH cluster genes on the risk of alcohol dependence: from GWAS to replication.


dbdate: 2013-05-30
author: Liu Z
date: 2013-02-28
journal: ScientificWorldJournal
link: http://www.ncbi.nlm.nih.gov/pubmed/23533358
study: NCK2 is significantly associated with opiates addiction in African-origin men.
trait: Addiction
region: 2q12.2
chrom: 2
reported_genes: NCK2
mapped_gene: NCK2
snp_gene_ids: 8440
strongest_risk_snp: rs2377339
strongest_risk_allele: G
snps: rs2377339
snp_id_current: 2377339
context: intron
pvalue_mlog: 11
ci_95: NR unit increase
platform: Illumina [859,185]
cnv: N
initial_samplesize:
1,393 European ancestry women, 1,131 European ancestry men, 568 African ancestry women, 535 African ancestry men


dbdate: 2013-05-26
author: Shi Y
date: 2013-02-28
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23406873
trait: Myopia (pathological)
initial_samplesize: 665 Han Chinese ancestry cases, 960 Han Chinese ancestry controls
replication_samplesize: 2,128 Han Chinese ancestry cases, 3,683 Han Chinese ancestry controls
region: 5q31.3
chrom: 5
reported_genes: PCDH1
mapped_gene: ARAP3 - PCDH1
upstream_gene_id: 64411
downstream_gene_id: 5097
strongest_risk_snp: rs248471
strongest_risk_allele: G
snps: rs248471
snp_id_current: 248471
context: Intergenic
pvalue_mlog: 5.698970004336018
ci_95: [1.11-1.28]
platform: Illumina [286,031]
cnv: N
study:
A genome-wide meta-analysis identifies two novel loci associated with high myopia in the Han Chinese population.


dbdate: 2013-05-31
author: Cousminer DL
date: 2013-02-27
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23449627
trait: Pubertal anthropometrics
initial_samplesize: 7,161 European ancestry males, 6,879 European ancestry females
replication_samplesize: 5,133 European ancestry males, 4,577 European ancestry females
region: 16p11.2
chrom: 16
reported_genes: MAPK3
mapped_gene: KCTD13 - TMEM219
upstream_gene_id: 253980
downstream_gene_id: 124446
strongest_risk_snp: rs4788196
strongest_risk_allele: G
snps: rs4788196
snp_id_current: 4788196
context: Intergenic
pvalue_mlog: 10.04575749056067
ci_95: [0.048-0.092] unit increase
platform: Illumina & Affymetrix [~2.5 million] (imputed)
cnv: N
study:
Genome-wide association and longitudinal analyses reveal genetic loci linking pubertal height growth, pubertal timing and childhood adiposity.


dbdate: 2013-06-06
author: Smoller JW
date: 2013-02-27
journal: Lancet
link: http://www.ncbi.nlm.nih.gov/pubmed/23453885
region: 20p13
chrom: 20
mapped_gene: TCF15 - SRXN1
upstream_gene_id: 6939
downstream_gene_id: 140809
strongest_risk_snp: rs1533087
strongest_risk_allele: T
snps: rs1533087
snp_id_current: 1533087
context: Intergenic
pvalue_mlog: 5.045757490560675
ci_95: [1.03-1.09]
platform: NR [1,252,901] (imputed)
cnv: N
study:
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.

trait:
Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined)

initial_samplesize:
6,990 European ancestry Bipolar disorder cases, 9,227 European ancestry Major depressive disorder cases, 9,379 European ancestry Schizophrenia cases, 161 European ancestry Autism spectrum disorder cases, 4,788 European ancestry Autism spectrum disorder trio cases, 840 European ancestry Attention deficit-hyperactivity disorder cases, 1,947 European ancestry Attention defcit-hyperactivity disorder trio cases, 27,888 European ancestry controls


dbdate: 2013-05-26
author: Zuo L
date: 2013-02-27
journal: Drug Alcohol Depend
link: http://www.ncbi.nlm.nih.gov/pubmed/23455491
trait: Alcohol dependence
initial_samplesize: 1,409 European ancestry cases, 1,518 European ancestry controls
replication_samplesize: 6,438 European ancestry individuals from 1,645 affected families
region: 1p35.2
chrom: 1
reported_genes: NKAIN1, SNRNP40, ZCCHC17, FABP3, SERINC2
mapped_gene: SERINC2
snp_gene_ids: 347735
strongest_risk_snp: rs4478858
strongest_risk_allele: G
snps: rs4478858
snp_id_current: 4478858
context: intron
pvalue_mlog: 7.522878745280337
platform: Illumina [805,814]
cnv: N
study:
NKAIN1-SERINC2 is a functional, replicable and genome-wide significant risk gene region specific for alcohol dependence in subjects of European descent.


dbdate: 2013-06-28
author: Chen Z
date: 2013-02-26
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23446634
study: Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network.
trait: Red blood cell traits
initial_samplesize: Up to 16,485 African American individuals
region: Xq28
chrom: 23
reported_genes: G6PD, TKTL1, MECP2, MPP1
mapped_gene: G6PD
snp_gene_ids: 2539
strongest_risk_snp: rs762516
strongest_risk_allele: T
snps: rs762516
snp_id_current: 762516
context: intron
pvalue_mlog: 15.69897000433602
ci_95: [0.34-0.56] % decrease
platform: Affymetrix & Illumina [NR]
cnv: N
replication_samplesize:
9,692 African American individuals, 21,020 European ancestry individuals, 14,088 Japanese ancestry individuals


dbdate: 2013-05-26
author: Kamboh MI
date: 2013-02-24
journal: Autoimmune Dis
link: http://www.ncbi.nlm.nih.gov/pubmed/23509613
study: Genome-wide association study of antiphospholipid antibodies.
trait: Presence of antiphospholipid antibodies
region: 5q11.2
chrom: 5
reported_genes: PELO
mapped_gene: RPS17P11 - PELO
upstream_gene_id: 100271072
downstream_gene_id: 53918
strongest_risk_snp: rs6889746
snps: rs6889746
snp_id_current: 6889746
context: Intergenic
pvalue_mlog: 5.221848749616356
ci_95: [NR]
platform: Affymetrix [906,600]
cnv: N
initial_samplesize:
183 European ancestry ACL-positive cases, 487 European ancestry ACL-negative controls, 127 European ancestry LAC-positive cases, 581 European ancestry LAC-negative controls, 136 European ancestry Anti-B2GPI-positive cases, 360 European ancestry Anti-B2GPI-negative controls


dbdate: 2013-05-21
author: Paternoster L
date: 2013-02-21
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23437003
trait: Bone mineral density
initial_samplesize: up to 5,878 European ancestry individuals
replication_samplesize: up to 1,052 European ancestry individuals
region: 13q14.11
chrom: 13
reported_genes: TNFSF11
mapped_gene: FABP3P2 - TNFSF11
upstream_gene_id: 56677
downstream_gene_id: 8600
strongest_risk_snp: rs1021188
strongest_risk_allele: C
snps: rs1021188
snp_id_current: 1021188
context: Intergenic
pvalue_mlog: 13.39794000867204
ci_95: [0.11-0.19] unit decrease
platform: Illumina [2,401,124] (Imputed)
cnv: N
study:
Genetic determinants of trabecular and cortical volumetric bone mineral densities and bone microstructure.


dbdate: 2013-06-06
author: Duggal P
date: 2013-02-19
journal: Ann Intern Med
link: http://www.ncbi.nlm.nih.gov/pubmed/23420232
trait: Chronic hepatitis C infection
initial_samplesize: 1,482 chronic HCV patients, 919 spontaneously cleared HCV patients
replication_samplesize: 461 chronic HCV patients, 284 spontaneously cleared HCV patients
region: 19q13.2
chrom: 19
reported_genes: IL-28B
mapped_gene: IFNL4
snp_gene_ids: 101180976
strongest_risk_snp: rs12979860
snps: rs12979860
snp_id_current: 12979860
context: intron
pvalue_mlog: 29.69897000433602
platform: Illumina [792,721] (Imputed)
cnv: N
study:
Genome-wide association study of spontaneous resolution of hepatitis C virus infection: data from multiple cohorts.


dbdate: 2013-05-17
author: Ludwig KU
date: 2013-02-19
journal: Transl Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/23423138
trait: Mathematical ability in children with dyslexia
initial_samplesize: 200 European ancestry cases
replication_samplesize: 510 European ancestry cases
region: 22q12.1
chrom: 22
reported_genes: MYO18B
mapped_gene: MYO18B
snp_gene_ids: 84700
strongest_risk_snp: rs133885
snps: rs133885
snp_id_current: 133885
context: missense
pvalue_mlog: 9.096910013008054
ci_95: % increase
platform: Illumina [NR]
cnv: N
study:
A common variant in myosin-18B contributes to mathematical abilities in children with dyslexia and intraparietal sulcus variability in adults.


dbdate: 2013-06-06
author: Ramanan VK
date: 2013-02-19
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/23419831
trait: Alzheimer's disease biomarkers
initial_samplesize: 555 European ancestry individuals
region: 3q26.1
chrom: 3
reported_genes: BCHE
mapped_gene: MTND3P7 - PSAT1P4
upstream_gene_id: 100873183
downstream_gene_id: 100287630
strongest_risk_snp: rs509208
strongest_risk_allele: G
snps: rs509208
snp_id_current: 509208
context: Intergenic
pvalue_mlog: 7.522878745280337
platform: Illumina [6,108,668] (imputed)
cnv: N
study:
APOE and BCHE as modulators of cerebral amyloid deposition: a florbetapir PET genome-wide association study.


dbdate: 2013-08-21
author: Thanassoulis G
date: 2013-02-17
journal: N Engl J Med
link: http://www.ncbi.nlm.nih.gov/pubmed/23388002
study: Genetic associations with valvular calcification and aortic stenosis.
trait: Aortic-valve calcification
initial_samplesize: 6,942 European ancestry individuals
region: 6q26
chrom: 6
reported_genes: LPA
mapped_gene: LPA
snp_gene_ids: 4018
strongest_risk_snp: rs10455872
strongest_risk_allele: G
snps: rs10455872
snp_id_current: 10455872
context: intron
pvalue_mlog: 10.52287874528034
ci_95: [1.66-2.53]
platform: Affymetrix & Illumina [>2.5 million] (Imputed)
cnv: N
replication_samplesize:
745 European ancestry individuals, 2,497 African American individuals, 2,027 Hispanic individuals, 774 Chinese ancestry individuals


dbdate: 2013-06-06
author: Tin A
date: 2013-02-16
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23417110
trait: Beta-2 microglubulin plasma levels
initial_samplesize: 6,728 European ancestry individuals
region: 6p22.1
chrom: 6
reported_genes: HLA-A
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs9260489
strongest_risk_allele: G
snps: rs9260489
snp_id_current: 9260489
pvalue_mlog: 21.69897000433602
ci_95: [0.032-0.048] unit decrease
platform: Affymetrix [2.5 million] (Imputed)
cnv: N
study:
Genome-wide association study identified the human leukocyte antigen region as a novel locus for plasma beta-2 microglobulin.


dbdate: 2013-05-11
author: Del-Aguila JL
date: 2013-02-12
journal: Pharmacogenomics J
link: http://www.ncbi.nlm.nih.gov/pubmed/23400010
trait: Thiazide-induced adverse metabolic effects in hypertensive patients
initial_samplesize: 425 European ancestry cases, 342 African American cases
region: 17q24.3
chrom: 17
reported_genes: SLC39A11
mapped_gene: LINC00511
snp_gene_ids: 400619
strongest_risk_snp: rs11077614
strongest_risk_allele: G
snps: rs11077614
snp_id_current: 11077614
context: ncRNA
pvalue_mlog: 5.522878745280337
ci_95: [1.92-4.58] mg/dL decrease
platform: Illumina and Affymetrics [>2 million] (Imputed)
cnv: N
study:
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.


dbdate: 2013-06-06
author: Verhoeven VJ
date: 2013-02-10
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23396134
trait: Refractive error
region: 2q37.1
chrom: 2
reported_genes: CHRNG, PRSS56
mapped_gene: CHRNG
snp_gene_ids: 1146
strongest_risk_snp: rs1881492
strongest_risk_allele: T
snps: rs1881492
snp_id_current: 1881492
context: intron
pvalue_mlog: 10.30102999566398
ci_95: [0.098-0.18] unit decrease
platform: Illumina & Affymetrix [2.5 million] (imputed)
cnv: N
study:
Genome-wide meta-analyses of multiancestry cohorts identify multiple new susceptibility loci for refractive error and myopia.

initial_samplesize:
37,382 European ancestry individuals, 578 Han Chinese ancestry individuals, 3,417 Singaporean Chinese ancestry individuals, 2,273 Singaporean Malay ancestry individuals, 2,108 Singaporean Indian ancestry individuals


dbdate: 2013-05-14
author: Porcu E
date: 2013-02-07
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23408906
trait: Thyroid hormone levels
region: 5q13.3
chrom: 5
reported_genes: PDE8B
mapped_gene: PDE8B
snp_gene_ids: 8622
strongest_risk_snp: rs6885099
snps: rs6885099
snp_id_current: 6885099
context: intron
pvalue_mlog: 25.69897000433602
ci_95: [0.12-0.16] unit decrease
platform: Illumina, Affymetrix [~2.5 Million] (Imputed)
cnv: N
study:
A meta-analysis of thyroid-related traits reveals novel loci and gender-specific differences in the regulation of thyroid function.

initial_samplesize:
up to 12,289 European ancestry females, up to 9,019 European ancestry males, up to 433 Old Order Amish females, up to 592 Old Order Amish males, 2,170 Sardinian females, 1,917 Sardinian males


dbdate: 2013-05-09
author: Verweij N
date: 2013-02-04
journal: Hypertension
link: http://www.ncbi.nlm.nih.gov/pubmed/23381795
trait: Circulating vasoactive peptide levels
initial_samplesize: 3,444 Euorpean ancestry individuals
replication_samplesize: 3,230 European ancestry individuals
region: 1q32.2
chrom: 1
reported_genes: KCNH1
mapped_gene: KCNH1
snp_gene_ids: 3756
strongest_risk_snp: rs1501550
strongest_risk_allele: A
snps: rs1501550
snp_id_current: 1501550
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [0.0071-0.0149] nmol/l decrease
platform: Illumina [2,269,099] (Imputed)
cnv: N
study:
Genome-wide association study on plasma levels of midregional-proadrenomedullin and C-terminal-pro-endothelin-1.


dbdate: 2013-05-08
author: Aberg KA
date: 2013-02-01
journal: JAMA Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/23894747
study: A comprehensive family-based replication study of schizophrenia genes.
trait: Schizophrenia
initial_samplesize: 11,185 European ancestry cases, 10,768 European ancestry controls
region: 1p34.3
chrom: 1
reported_genes: GRIK3
mapped_gene: FTLP18 - GRIK3
upstream_gene_id: 100462786
downstream_gene_id: 2899
strongest_risk_snp: rs589249
strongest_risk_allele: G
snps: rs589249
snp_id_current: 589249
context: Intergenic
pvalue_mlog: 6.522878745280337
ci_95: [NR]
platform: NR [1,085,772] (Imputed)
cnv: N
replication_samplesize:
1,262 African American ancestry individuals, 2,740 European ancestry individuals, 2,296 Asian ancestry individuals


dbdate: 2013-05-09
author: GENDEP Investigators
date: 2013-02-01
journal: Am J Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/23377640
trait: Major depressive disorder
initial_samplesize: Up to 2,256 European ancestry cases
region: 5p15.1
chrom: 5
reported_genes: MYO10
mapped_gene: MYO10
snp_gene_ids: 4651
strongest_risk_snp: rs17651119
strongest_risk_allele: C
snps: rs17651119
snp_id_current: 17651119
context: intron
pvalue_mlog: 7.698970004336018
ci_95: [2.77-3.59]
platform: Illumina & Affymetrix [1.2 million] (Imputed)
cnv: N
study:
Common genetic variation and antidepressant efficacy in major depressive disorder: a meta-analysis of three genome-wide pharmacogenetic studies.


dbdate: 2013-05-09
author: Xie W
date: 2013-02-01
journal: Diabetes
link: http://www.ncbi.nlm.nih.gov/pubmed/23378610
trait: Metabolite levels
initial_samplesize: 1,004 European ancestry individuals
replication_samplesize: 339 European ancestry individuals
region: 1p12
chrom: 1
reported_genes: PHGDH
mapped_gene: PHGDH
snp_gene_ids: 26227
strongest_risk_snp: rs478093
strongest_risk_allele: G
snps: rs478093
snp_id_current: 478093
context: intron
pvalue_mlog: 13.69897000433602
platform: Affymetrix [909,508] (imputed)
cnv: N
study:
Genetic variants associated with glycine metabolism and their role in insulin sensitivity and type 2 diabetes.


dbdate: 2013-05-09
author: Dai X
date: 2013-01-31
journal: Genet Epidemiol
link: http://www.ncbi.nlm.nih.gov/pubmed/23371916
trait: Bilirubin levels
initial_samplesize: 1,452 Han Chinese ancestry individuals
replication_samplesize: 8,830 Han Chinese ancestry individuals
region: 2q37.1
chrom: 2
reported_genes: UGT1A1
mapped_gene: UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A1;UGT1A3
snp_gene_ids: 54575;54576;54577;54578;54579;54600;54657;54658;54659
strongest_risk_snp: rs6742078
snps: rs6742078
snp_id_current: 6742078
context: intron;intron;intron;intron;intron;intron;intron;intron;intron
pvalue_mlog: 88.99999999999999
ci_95: [0.14-0.17] unit increase
platform: Affymetrix [658,288] (Imputed)
cnv: N
study:
A genome-wide association study for serum bilirubin levels and gene-environment interaction in a Chinese population.


dbdate: 2013-05-09
author: Kerns SL
date: 2013-01-31
journal: J Urol
link: http://www.ncbi.nlm.nih.gov/pubmed/23376709
trait: Urinary symptoms in response to radiotherapy in prostate cancer
initial_samplesize: 346 European, African, Hispanic and Asian ancestry individuals
replication_samplesize: 377 European, African, Hispanic and Asian ancestry individuals
region: 9p21.2
chrom: 9
reported_genes: IFNK, MOB3B
mapped_gene: MOB3B
snp_gene_ids: 79817
strongest_risk_snp: rs17779457
snps: rs17779457
snp_id_current: 17779457
context: intron
pvalue_mlog: 6.154901959985743
ci_95: [1.1-3.6] unit increase
platform: Affymetrix [613,496]
cnv: N
study:
A 2-stage genome-wide association study to identify single nucleotide polymorphisms associated with development of urinary symptoms after radiotherapy for prostate cancer.


dbdate: 2013-06-14
author: Lauc G
date: 2013-01-31
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23382691
trait: IgG glycosylation
initial_samplesize: 1,848 European ancestry individuals
region: 3q27.3
chrom: 3
reported_genes: ST6GAL1
mapped_gene: ST6GAL1
snp_gene_ids: 6480
strongest_risk_snp: rs11710456
strongest_risk_allele: G
snps: rs11710456
snp_id_current: 11710456
context: intron
pvalue_mlog: 6.096910013008056
ci_95: [0.027-0.061] unit decrease
platform: Illumina [~ 2.5 Million] (Imputed)
cnv: N
study:
Loci associated with N-glycosylation of human immunoglobulin G show pleiotropy with autoimmune diseases and haematological cancers.


dbdate: 2013-05-02
author: Borglum AD
date: 2013-01-29
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/23358160
trait: Schizophrenia
initial_samplesize: 888 European ancestry cases, 882 European ancestry controls
replication_samplesize: 2539 European ancestry cases, 5486 European ancestry controls
region: 11p15.2
chrom: 11
reported_genes: ARNTL
mapped_gene: ARNTL
snp_gene_ids: 406
strongest_risk_snp: rs4757144
strongest_risk_allele: G
snps: rs4757144
snp_id_current: 4757144
context: intron
pvalue_mlog: 5.301029995663981
platform: Illumina [541,148]
cnv: N
study:
Genome-wide study of association and interaction with maternal cytomegalovirus infection suggests new schizophrenia loci.


dbdate: 2013-05-02
author: Martinelli-Boneschi F
date: 2013-01-29
journal: Neurobiol Aging
link: http://www.ncbi.nlm.nih.gov/pubmed/23374588
trait: Response to cholinesterase inhibitors in Alzheimer's disease
initial_samplesize: 92 European ancestry cases, 77 European ancestry controls
replication_samplesize: 94 European ancestry cases, 74 European ancestry controls
region: 3q24
chrom: 3
reported_genes: SLC9A9
mapped_gene: SLC9A9
snp_gene_ids: 285195
strongest_risk_snp: rs17636071
strongest_risk_allele: G
snps: rs17636071
snp_id_current: 17636071
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [NR] unit decrease
platform: Illumina [522,109]
cnv: N
study:
Pharmacogenomics in Alzheimer's disease: a genome-wide association study of response to cholinesterase inhibitors.


dbdate: 2013-06-05
author: Wu JH
date: 2013-01-29
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23362303
trait: Oleic acid (18:1n-9) plasma levels
initial_samplesize: 8,961 European ancestry individuals
region: 11q12.2
chrom: 11
reported_genes: C11orf10, C11orf9, FADS1, FADS2, FADS3, FEN1, RAB3IL1
mapped_gene: TMEM258
snp_gene_ids: 746
strongest_risk_snp: rs102275
strongest_risk_allele: C
snps: rs102275
snp_id_current: 102275
context: intron
pvalue_mlog: 31.69897000433602
ci_95: [0.192-0.268] unit increase
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortium.


dbdate: 2013-05-01
author: Xu C
date: 2013-01-29
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/23382809
trait: Schizophrenia (negative symptoms)
initial_samplesize: 1,774 European ancestry cases, 2,726 European ancestry controls
region: 1q21.2
chrom: 1
reported_genes: BCL9
mapped_gene: BCL9
snp_gene_ids: 607
strongest_risk_snp: rs583583
strongest_risk_allele: A
snps: rs583583
snp_id_current: 583583
context: intron
pvalue_mlog: 6.221848749616355
ci_95: [NR]
platform: Affymetrix [729,454]
cnv: N
study:
BCL9 and C9orf5 are associated with negative symptoms in schizophrenia: meta-analysis of two genome-wide association studies.


dbdate: 2013-04-23
author: Fernandez-Rozadilla C
date: 2013-01-26
journal: BMC Genomics
link: http://www.ncbi.nlm.nih.gov/pubmed/23350875
trait: Colorectal cancer
initial_samplesize: 882 European ancestry cases, 473 European ancestry controls
replication_samplesize: 1,436 European ancestry cases, 1,780 European ancestry controls
region: 3p21.31
chrom: 3
mapped_gene: KLHL18 - PTPN23
upstream_gene_id: 23276
downstream_gene_id: 25930
strongest_risk_snp: rs8180040
snps: rs8180040
snp_id_current: 8180040
context: Intergenic
pvalue_mlog: 5.698970004336018
ci_95: [1.15-1.41]
platform: Affymetrix [674,718]
cnv: N
study:
A colorectal cancer genome-wide association study in a Spanish cohort identifies two variants associated with colorectal cancer risk at 1p33 and 8p12.


dbdate: 2013-04-24
author: Rinella ES
date: 2013-01-25
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23354978
trait: Breast cancer
initial_samplesize: 477 Ashkenazi Jewish cases, 524 Ashkenazi Jewish controls
replication_samplesize: 203 Ashkenazi Jewish cases, 263 Ashkenazi Jewish contols
region: 6p22.3
chrom: 6
reported_genes: Intergenic
mapped_gene: RNA5SP205 - KRT18P38
upstream_gene_id: 100873466
downstream_gene_id: 441133
strongest_risk_snp: rs16882214
snps: rs16882214
snp_id_current: 16882214
context: Intergenic
pvalue_mlog: 5.698970004336018
ci_95: [NR]
platform: Affymetrix [435,632]
cnv: N
study:
Genetic variants associated with breast cancer risk for Ashkenazi Jewish women with strong family histories but no identifiable BRCA1/2 mutation.


dbdate: 2013-04-17
author: Dong J
date: 2013-01-17
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23341777
trait: Squamous cell carcinoma
initial_samplesize: 833 Han Chinese ancestry cases, 3,094 Han Chinese ancestry controls
replication_samplesize: 2,223 Han Chinese ancestry cases, 6,409 Han Chinese ancestry controls
region: 12q23.1
chrom: 12
reported_genes: SLC17A8, NR1H4, SCYL2, GAS2L3
mapped_gene: SLC17A8 - NR1H4
upstream_gene_id: 246213
downstream_gene_id: 9971
strongest_risk_snp: rs12296850
strongest_risk_allele: A
snps: rs12296850
snp_id_current: 12296850
context: Intergenic
pvalue_mlog: 10
ci_95: [1.19-1.39]
platform: Affymetrix [570,009]
cnv: N
study:
Genome-wide association study identifies a novel susceptibility locus at 12q23.1 for lung squamous cell carcinoma in han chinese.


dbdate: 2013-04-17
author: Vijai J
date: 2013-01-17
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23349640
study: Susceptibility loci associated with specific and shared subtypes of lymphoid malignancies.
trait: Lymphoma
region: 6p23
chrom: 6
reported_genes: RNF182, JARID2
mapped_gene: LOC101928354
snp_gene_ids: 101928354
strongest_risk_snp: rs707824
strongest_risk_allele: T
snps: rs707824
snp_id_current: 707824
context: intron
pvalue_mlog: 6.221848749616355
ci_95: [1.17-1.47]
platform: Affymetrix [530,583]
cnv: N
initial_samplesize:
275 Follicular non-Hodgkin�s Lymphoma cases, 269 diffuse large B-cell non-Hodgkin�s Lymphoma cases, 198 other non-Hodgkin�s Lymphoma cases, 202 Hodgkin�s Lymphoma cases, 4,044 controls

replication_samplesize:
202 European ancestry Follicular non-Hodgkin�s Lymphoma cases, 367 European ancestry diffuse large B-cell non-Hodgkin�s Lymphoma cases, 577 European ancestry other non-Hodgkin�s Lymphoma cases, 99 European ancestry Hodgkin�s Lymphoma cases, 2,596 European ancestry controls


dbdate: 2013-04-04
author: Tin A
date: 2013-01-16
journal: Nephrol Dial Transplant
link: http://www.ncbi.nlm.nih.gov/pubmed/23328707
trait: Beta-trace protein levels
initial_samplesize: 6,720 European ancestry individuals
replication_samplesize: 1,734 African American individuals
region: 9q34.3
chrom: 9
reported_genes: PTGDS
mapped_gene: LOC101928638
snp_gene_ids: 101928638
strongest_risk_snp: rs57024841
strongest_risk_allele: A
snps: rs57024841
snp_id_current: 57024841
context: nearGene-5
pvalue_mlog: 23
ci_95: [0.040-0.060] unit increase
platform: Affymetrix [~2.5 Million] (Imputed)
cnv: N
study:
Genome-wide significant locus of beta-trace protein, a novel kidney function biomarker, identified in European and African Americans.


dbdate: 2013-03-26
author: Urabe Y
date: 2013-01-12
journal: J Hepatol
link: http://www.ncbi.nlm.nih.gov/pubmed/23321320
trait: Hepatitis C induced liver cirrhosis
initial_samplesize: 682 Japanese ancestry cases, 1,045 Japanese ancestry controls
replication_samplesize: 936 Japanese ancestry cases, 3,809 Japanese ancestry controls
region: 6p21.32
chrom: 6
reported_genes: C6orf10
mapped_gene: C6orf10
snp_gene_ids: 10665
strongest_risk_snp: rs910049
strongest_risk_allele: A
snps: rs910049
snp_id_current: 910049
context: intron
pvalue_mlog: 10.04575749056067
ci_95: [1.28-1.62]
platform: Illumina [431,618]
cnv: N
study:
A genome-wide association study of HCV-induced liver cirrhosis in the Japanese population identifies novel susceptibility loci at the MHC region.


dbdate: 2013-04-19
author: Holliday EG
date: 2013-01-11
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/23326517
trait: Age-related macular degeneration
initial_samplesize: 3,772 European ancestry cases, 16,033 European ancestry controls
replication_samplesize: 264 Asian ancestry cases, 3,926 Asian ancestry controls
region: 1q31.3
chrom: 1
reported_genes: CFH
mapped_gene: CFH
snp_gene_ids: 3075
strongest_risk_snp: rs1329424
strongest_risk_allele: T
snps: rs1329424
snp_id_current: 1329424
context: intron
pvalue_mlog: 30.69897000433602
ci_95: [1.33-1.49]
platform: Illumina & Affymetrix [~2.5 million] Imputed
cnv: N
study:
Insights into the genetic architecture of early stage age-related macular degeneration: a genome-wide association study meta-analysis.


dbdate: 2013-04-12
author: Greenwood TA
date: 2013-01-10
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/23326512
trait: Bipolar disorder (mania)
replication_samplesize: 121 European ancestry Irritable maniacases, 1026 European ancestry Elated mania cases
region: 13q31.1
chrom: 13
reported_genes: SLITRK1, SLITRK6
mapped_gene: MTND5P3 - LINC00351
upstream_gene_id: 100873210
downstream_gene_id: 100874137
strongest_risk_snp: rs17079247
strongest_risk_allele: T
snps: rs17079247
snp_id_current: 17079247
context: Intergenic
pvalue_mlog: 5.096910013008055
platform: Affymetrix [703,012]
cnv: N
study:
Genome-wide association study of irritable vs. elated mania suggests genetic differences between clinical subtypes of bipolar disorder.

initial_samplesize:
117 European ancestry Irritable mania cases, 843 European ancestry Elated mania cases, 1033 European ancestry controls


dbdate: 2013-05-01
author: Rubicz R
date: 2013-01-10
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23326239
trait: Epstein-Barr virus immune response (EBNA-1)
initial_samplesize: 1,367 Mexican American indivduals
replication_samplesize: 589 Mexican American indivduals
region: 6p21.32
chrom: 6
reported_genes: HLA-DRB1
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs477515
strongest_risk_allele: T
snps: rs477515
snp_id_current: 477515
pvalue_mlog: 12.52287874528034
ci_95: [NR] unit decrease
platform: Illumina [944,565]
cnv: N
study:
A genome-wide integrative genomic study localizes genetic factors influencing antibodies against Epstein-Barr virus nuclear antigen 1 (EBNA-1).


dbdate: 2013-03-27
author: Saxena R
date: 2013-01-08
journal: Diabetes
link: http://www.ncbi.nlm.nih.gov/pubmed/23300278
trait: Type 2 diabetes
initial_samplesize: 842 Punjabi Sikh cases, 774 Punjabi Sikh controls
region: 10q25.2
chrom: 10
reported_genes: TCF7L2
mapped_gene: TCF7L2
snp_gene_ids: 6934
strongest_risk_snp: rs7903146
strongest_risk_allele: T
snps: rs7903146
snp_id_current: 7903146
context: intron
pvalue_mlog: 18.52287874528033
ci_95: [1.33 - 1.56]
platform: Illumina [1,232,008] (imputed)
cnv: N
study:
Genome-wide association study identifies a novel locus contributing to type 2 diabetes susceptibility in Sikhs of Punjabi origin from India.

replication_samplesize:
up to 2,512 Punjabi Sikh cases and 3,201 Punjabi Sikh controls; up to 16,128 South Asian cases and 23,846 South Asian controls; up to 16,746 East Asian ancestry cases and 16,961 East Asian ancestry controls; up to 8,130 European ancestry cases and 38,987 European ancestry controls


dbdate: 2013-04-17
author: Cordell HJ
date: 2013-01-07
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23297363
trait: Tetralogy of Fallot
initial_samplesize: 835 European ancestry cases, 5,159 European ancestry controls
replication_samplesize: 798 European ancestry cases and 2,931 European ancestry controls
region: 10p14
chrom: 10
reported_genes: Intergenic
mapped_gene: RNA5SP299 - LINC00709
upstream_gene_id: 100873574
downstream_gene_id: 100507163
strongest_risk_snp: rs2388896
strongest_risk_allele: G
snps: rs2388896
snp_id_current: 2388896
context: Intergenic
pvalue_mlog: 7.045757490560674
ci_95: [1.15-1.43]
platform: Illumina [516,131]
cnv: N
study:
Genome-wide association study identifies loci on 12q24 and 13q32 associated with tetralogy of Fallot.


dbdate: 2013-04-11
author: He M
date: 2013-01-07
journal: Gut
link: http://www.ncbi.nlm.nih.gov/pubmed/23300138
trait: Tumor biomarkers
initial_samplesize: 3,451 Han Chinese ancestry individuals
replication_samplesize: 10,326 Chinese ancestry individuals
region: 19p13.11
chrom: 19
reported_genes: B3GNT3
mapped_gene: FCHO1 - B3GNT3
upstream_gene_id: 23149
downstream_gene_id: 10331
strongest_risk_snp: rs265548
strongest_risk_allele: C
snps: rs265548
snp_id_current: 265548
context: Intergenic
pvalue_mlog: 13
ci_95: [0.029-0.115] U/ml decrease
platform: Illumina & Affymetrix [NR] imputed
cnv: N
study:
A genome wide association study of genetic loci that influence tumour biomarkers cancer antigen 19-9, carcinoembryonic antigen and &#x003b1; fetoprotein and their associations with cancer risk.


dbdate: 2013-03-21
author: Donnelly
date: 2013-01-06
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23291585
trait: Leishmaniasis (visceral)
replication_samplesize: 889 Indian ancestry cases, 948 Indian ancestry controls.
region: 6p21.32
chrom: 6
reported_genes: HLA-DRB1, HLA-DQA1, HLA
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs9271858
strongest_risk_allele: G
snps: rs9271858
snp_id_current: 9271858
pvalue_mlog: 16.52287874528034
ci_95: [1.30-1.52]
platform: Illumina [521,134]
cnv: N
study:
Common variants in the HLA-DRB1-HLA-DQA1 HLA class II region are associated with susceptibility to visceral leishmaniasis.

initial_samplesize:
889 Indian ancestry cases, 977 Indian ancestry controls, 357 Brazilian ancestry cases, and 1,615 Brazilian ancestry unaffected relatives


dbdate: 2013-03-27
author: Kirino Y
date: 2013-01-06
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23291587
trait: Behcet's disease
initial_samplesize: 435 Turkish cases with uveitis, 780 Turkish cases without uveitis, 1,278 Turkish controls
region: 3p21.31
chrom: 3
reported_genes: CCR1, CCR3
mapped_gene: FLT1P1 - CCR1
upstream_gene_id: 391533
downstream_gene_id: 1230
strongest_risk_snp: rs7616215
strongest_risk_allele: C
snps: rs7616215
snp_id_current: 7616215
context: Intergenic
pvalue_mlog: 12.39794000867204
ci_95: [1.27-1.52]
platform: Illumina [779,465] (imputed)
cnv: N
study:
Genome-wide association analysis identifies new susceptibility loci for Beh&#x000e7;et's disease and epistasis between HLA-B*51 and ERAP1.

replication_samplesize:
355 Turkish cases with uveitis, 483 Turkish cases without uveitis, 601 Turkish controls, up to 612 Japanese ancestry cases, up to 740 Japanese ancestry controls


dbdate: 2013-03-28
author: Lu Y
date: 2013-01-06
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23291589
trait: Corneal structure
region: 1p34.3
chrom: 1
reported_genes: COL8A2
mapped_gene: COL8A2
snp_gene_ids: 1296
strongest_risk_snp: rs96067
strongest_risk_allele: A
snps: rs96067
snp_id_current: 96067
context: intron
pvalue_mlog: 10.52287874528034
ci_95: [-0.0092-0.0692] unit increase
platform: Illumina & Affymetrix [~1 Million] (Imputed)
cnv: N
study:
Genome-wide association analyses identify multiple loci associated with central corneal thickness and keratoconus.

initial_samplesize:
13,057 European ancestry individuals, 2,538 Indian ancestry individuals, 2,542 Malay ancestry individuals, 1,883 Chinese ancestry individuals


dbdate: 2013-03-20
author: Guggenheim JA
date: 2013-01-03
journal: Mol Vis
link: http://www.ncbi.nlm.nih.gov/pubmed/23401653
trait: Corneal curvature
initial_samplesize: 2,023 European ancestry children
region: 4q12
chrom: 4
reported_genes: PDGFRA
mapped_gene: RPL22P13
snp_gene_ids: 442108
strongest_risk_snp: rs17084051
strongest_risk_allele: A
snps: rs17084051
snp_id_current: 17084051
pvalue_mlog: 13.30102999566398
ci_95: [0.093-0.159] (unit decrease)
platform: Illumina [2,543,887] (Imputed)
cnv: N
study:
A genome-wide association study for corneal curvature identifies the platelet-derived growth factor receptor &#x003b1; gene as a quantitative trait locus for eye size in white Europeans.

replication_samplesize:
2,008 Chinese ancestry adults, 2,281 Malay ancestry adults, 2,142 Indian ancestry adults, 929 Chinese ancestry children


dbdate: 2013-03-19
author: Athanasiadis G
date: 2013-01-02
journal: J Thromb Haemost
link: http://www.ncbi.nlm.nih.gov/pubmed/23279374
trait: &beta;2-Glycoprotein I (&beta;2-GPI) plasma levels
initial_samplesize: 306 European ancestry individuals
region: 11p13
chrom: 11
reported_genes: ELF5
mapped_gene: ELF5 - EHF
upstream_gene_id: 2001
downstream_gene_id: 26298
strongest_risk_snp: rs836132
strongest_risk_allele: C
snps: rs836132
snp_id_current: 836132
context: Intergenic
pvalue_mlog: 7.30102999566398
ci_95: (unit increase)
platform: Illumina [283,437]
cnv: N
study:
Genetic determinants of plasma &#x003b2;&#x02082;-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.


dbdate: 2013-06-18
author: Li WD
date: 2013-01-02
journal: Obesity (Silver Spring)
link: http://www.ncbi.nlm.nih.gov/pubmed/23703922
trait: Uric acid levels
initial_samplesize: 487 European ancestry obese individuals, 472 non-obese individuals
region: 4p16.1
chrom: 4
reported_genes: SLC2A9
mapped_gene: SLC2A9
snp_gene_ids: 56606
strongest_risk_snp: rs6449213
snps: rs6449213
snp_id_current: 6449213
context: intron
pvalue_mlog: 11.52287874528034
platform: Illumina [~550,000]
cnv: N
study:
A genome wide association study of plasma uric acid levels in obese cases and never-overweight controls.


dbdate: 2013-03-27
author: Jin G
date: 2013-01-01
journal: Neoplasia
link: http://www.ncbi.nlm.nih.gov/pubmed/23359319
trait: Prostate-specific antigen levels
initial_samplesize: 3,192 European ancestry individuals
replication_samplesize: 1,722 European ancestry individuals
region: 12p13.1
chrom: 12
reported_genes: ATF7IP
mapped_gene: ATF7IP
snp_gene_ids: 55729
strongest_risk_snp: rs3213764
strongest_risk_allele: G
snps: rs3213764
snp_id_current: 3213764
context: missense
pvalue_mlog: 8.698970004336019
ci_95: % increase
platform: Illumina [642,584]
cnv: N
study:
Genome-wide association study identifies loci at ATF7IP and KLK2 associated with percentage of circulating free PSA.


dbdate: 2013-03-22
author: Sun J
date: 2012-12-27
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23269536
trait: Prostate-specific antigen levels
initial_samplesize: 1,999 Chinese ancestry males
replication_samplesize: 1,496 Chinese ancestry males
region: 1q32.1
chrom: 1
reported_genes: SLC45A3, NUCKS1, RAB7L1, SLC41A1, FLJ32569
mapped_gene: SLC45A3
snp_gene_ids: 85414
strongest_risk_snp: rs12409639
strongest_risk_allele: A
snps: rs12409639
snp_id_current: 12409639
context: intron
pvalue_mlog: 18.69897000433602
ci_95: [NR] % higher levels
platform: Illumina [>709,211] (imputed)
cnv: N
study:
Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.


dbdate: 2013-02-21
author: Yang W
date: 2012-12-27
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23273568
trait: Systemic lupus erythematosus
initial_samplesize: 1,656 Han Chinese ancestry cases, 3,394 Han Chinese ancestry controls
region: 2p13.1
chrom: 2
reported_genes: TET3, DGUOK
mapped_gene: DGUOK-AS1
snp_gene_ids: 100874048
strongest_risk_snp: rs6705628
strongest_risk_allele: C
snps: rs6705628
snp_id_current: 6705628
context: ncRNA
pvalue_mlog: 16.15490195998574
platform: Illumina [2,100,739] (imputed)
cnv: N
study:
Meta-analysis followed by replication identifies loci in or near CDKN1B, TET3, CD80, DRAM1, and ARID5B as associated with systemic lupus erythematosus in Asians.

replication_samplesize:
3,256 Han Chinese ancestry cases, 5,667 Han Chinese ancestry controls, 453 Thai ancestry cases, 963 Thai ancestry controls


dbdate: 2013-02-21
author: Desch KC
date: 2012-12-24
journal: Proc Natl Acad Sci U S A
link: http://www.ncbi.nlm.nih.gov/pubmed/23267103
trait: Coagulation factor levels
initial_samplesize: 3,250 European ancestry individuals, up to 212 individuals
region: 9q34.2
chrom: 9
reported_genes: ABO, LOC653163, ADAMTS13, OBP2B, OBP2A, C9orf96, LOC286310, SURF6, SURF5
mapped_gene: ABO
snp_gene_ids: 28
strongest_risk_snp: rs687289
strongest_risk_allele: T
snps: rs687289
snp_id_current: 687289
context: intron
pvalue_mlog: 128
ci_95: [0.30-0.36] lU/dL increase
platform: Illumina [723,716]
cnv: N
study:
Linkage analysis identifies a locus for plasma von Willebrand factor undetected by genome-wide association.


dbdate: 2013-03-05
author: Jia WH
date: 2012-12-23
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23263487
trait: Colorectal cancer
initial_samplesize: 2,098 East Asian ancestry cases, 5,749 East Asian ancestry controls
region: 12p13.32
chrom: 12
reported_genes: CCND2, PARP11, FGF23, FGF6, C12orf5, RAD51AP1
mapped_gene: RPL18P9 - CCND2
upstream_gene_id: 100129645
downstream_gene_id: 894
strongest_risk_snp: rs10774214
strongest_risk_allele: T
snps: rs10774214
snp_id_current: 10774214
context: Intergenic
pvalue_mlog: 7.522878745280337
ci_95: [1.06-1.13]
platform: Illumina & Affymetrix (1,636,380) imputed
cnv: N
study:
Genome-wide association analyses in East Asians identify new susceptibility loci for colorectal cancer.

replication_samplesize:
5,358 East Asian ancestry cases, 5,922 East Asian ancestry controls, 26,060 European ancestry individuals


dbdate: 2013-02-19
author: Peters U
date: 2012-12-21
journal: Gastroenterology
link: http://www.ncbi.nlm.nih.gov/pubmed/23266556
study: Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis.
trait: Colorectal cancer
initial_samplesize: 12,696 European ancestry colorectal tumor cases, and 15,113 European ancestry controls
region: 8q24.21
chrom: 8
reported_genes: MYC
mapped_gene: CCAT2;LOC101930033
snp_gene_ids: 101805488;101930033
strongest_risk_snp: rs6983267
strongest_risk_allele: G
snps: rs6983267
snp_id_current: 6983267
context: ncRNA;intron
pvalue_mlog: 11
ci_95: [1.09-1.18]
platform: Illumina & Affymetrix [2,708,280] imputed
cnv: N
replication_samplesize:
958 European ancestry colorectal tumor cases, up to 2,098 East Asian ancestry colorectal tumor cases, 909 European ancestry controls, up to 5,749 East Asian ancestry controls


dbdate: 2013-02-26
author: Wang X
date: 2012-12-21
journal: BMC Oral Health
link: http://www.ncbi.nlm.nih.gov/pubmed/23259602
study: Genome-wide association scan of dental caries in the permanent dentition.
trait: Dental caries
region: 1p21.3
chrom: 1
reported_genes: PAP2D, SNX7
mapped_gene: LPPR5
snp_gene_ids: 163404
strongest_risk_snp: rs1571500
snps: rs1571500
snp_id_current: 1571500
context: intron
pvalue_mlog: 5.698970004336018
platform: Illumina and Affymetrix [~ 1.4 Million] (imputed)
cnv: N
initial_samplesize:
1,483 comparatively younger European ancestry individuals, 5,960 comparatively older European ancestry individuals


dbdate: 2013-02-27
author: Yamazaki K
date: 2012-12-21
journal: Gastroenterology
link: http://www.ncbi.nlm.nih.gov/pubmed/23266558
trait: Crohn's disease
initial_samplesize: 372 Japanese ancestry cases and 3,389 Japanese ancestry controls
replication_samplesize: Up to 1,151 Japanese ancestry cases and up to 15,800 Japanese ancestry controls
region: 1p36.11
chrom: 1
reported_genes: RUNX3
mapped_gene: RUNX3
snp_gene_ids: 864
strongest_risk_snp: rs7551188
strongest_risk_allele: T
snps: rs7551188
snp_id_current: 7551188
context: intron
pvalue_mlog: 5.045757490560675
ci_95: [1.10-1.28]
platform: Illumina [4,929,034] (imputed)
cnv: N
study:
A genome-wide association study identifies 2 susceptibility Loci for Crohn's disease in a Japanese population.


dbdate: 2013-02-27
author: Hancock DB
date: 2012-12-20
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23284291
trait: Pulmonary function (interaction)
initial_samplesize: 50,047 European ancestry individuals
region: 1p36.13
chrom: 1
reported_genes: MFAP2
mapped_gene: MFAP2
snp_gene_ids: 4237
strongest_risk_snp: rs2284746
snps: rs2284746
snp_id_current: 2284746
context: intron
pvalue_mlog: 10.69897000433602
platform: NR [~2.5 Million] (imputed)
cnv: N
study:
Genome-wide joint meta-analysis of SNP and SNP-by-smoking interaction identifies novel loci for pulmonary function.


dbdate: 2013-03-15
author: Li J
date: 2012-12-20
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23263863
trait: Hematology traits
initial_samplesize: 7,943 African American children, 6,234 European ancestry children
region: 11p15.4
chrom: 11
reported_genes: HBE1, HBB, HBD, HBBP1, HBG1
mapped_gene: LCRB
snp_gene_ids: 387281
strongest_risk_snp: rs2213169
strongest_risk_allele: T
snps: rs2213169
snp_id_current: 2213169
pvalue_mlog: 10.30102999566398
ci_95: [0.31-0.58] unit decrease
platform: Illumina [544,917]
cnv: N
study:
GWAS of blood cell traits identifies novel associated loci and epistatic interactions in Caucasian and African-American children.


dbdate: 2013-03-06
author: Makela KM
date: 2012-12-17
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23247145
trait: LDL (oxidized)
initial_samplesize: 2,080 European ancestry individuals
replication_samplesize: 4,238 European ancestry individuals
region: 2p24.1
chrom: 2
reported_genes: apoB
mapped_gene: APOB
snp_gene_ids: 338
strongest_risk_snp: rs676210
strongest_risk_allele: G
snps: rs676210
snp_id_current: 676210
context: missense
pvalue_mlog: 46.52287874528033
ci_95: (U/L increase)
platform: Illumina [2,543,887] (imputed)
cnv: N
study:
Genome-wide association study pinpoints a new functional apolipoprotein B variant influencing oxidized low-density lipoprotein levels but not cardiovascular events: AtheroRemo Consortium.


dbdate: 2013-03-11
author: Jiang DK
date: 2012-12-16
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23242368
trait: Hepatocellular carcinoma (hepatitis B virus related)
initial_samplesize: 1,161 Chinese ancestry cases, 1,353 Chinese ancestry controls
replication_samplesize: 4,319 Chinese ancestry cases, 4,966 Chinese ancestry controls
region: 2q32.3
chrom: 2
reported_genes: STAT4
mapped_gene: STAT4
snp_gene_ids: 6775
strongest_risk_snp: rs7574865
strongest_risk_allele: G
snps: rs7574865
snp_id_current: 7574865
context: intron
pvalue_mlog: 9.698970004336017
ci_95: [1.14-1.28]
platform: Illumina (1,672,517) imputed
cnv: N
study:
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.


dbdate: 2013-02-27
author: Yu B
date: 2012-12-16
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23247143
trait: Cardiac Troponin-T levels
initial_samplesize: 9,491 European ancestry individuals, up to 2,053 African American individuals
region: 8q13.3
chrom: 8
reported_genes: NCOA2, TRAM1
mapped_gene: LOC101926892
snp_gene_ids: 101926892
strongest_risk_snp: rs10091374
strongest_risk_allele: A
snps: rs10091374
snp_id_current: 10091374
context: intron
pvalue_mlog: 8.045757490560675
ci_95: [0.027-0.059] ug/L decrease
platform: Affymetrix and Illumina [~2.5 Million] (imputed)
cnv: N
study:
Association of genome-wide variation with highly sensitive cardiac troponin-T levels in European Americans and Blacks: a meta-analysis from atherosclerosis risk in communities and cardiovascular health studies.


dbdate: 2013-02-19
author: Clark SL
date: 2012-12-12
journal: Pharmacogenet Genomics
link: http://www.ncbi.nlm.nih.gov/pubmed/23241943
trait: Response to antipsychotic treatment
region: 1q23.2
chrom: 1
reported_genes: ATP1A2
mapped_gene: IGSF8 - ATP1A2
upstream_gene_id: 93185
downstream_gene_id: 477
strongest_risk_snp: rs6688363
strongest_risk_allele: T
snps: rs6688363
snp_id_current: 6688363
context: Intergenic
pvalue_mlog: 6.698970004336019
platform: Affymetrix [492,900]
cnv: N
study:
Genome-wide association study of patient-rated and clinician-rated global impression of severity during antipsychotic treatment.

initial_samplesize:
Up to 421 European ancestry Schizophrenia cases, up to 214 African American individuals, up to 103 individuals


dbdate: 2013-02-19
author: Aragam N
date: 2012-12-11
journal: J Mol Neurosci
link: http://www.ncbi.nlm.nih.gov/pubmed/23229837
trait: Neuroticism
initial_samplesize: 2,748 European ancestry cases
region: 19p13.3
chrom: 19
reported_genes: TMPRSS9
mapped_gene: TMPRSS9
snp_gene_ids: 360200
strongest_risk_snp: rs4806846
strongest_risk_allele: A
snps: rs4806846
snp_id_current: 4806846
context: intron
pvalue_mlog: 5.096910013008055
platform: Perlegen [437,547]
cnv: N
study:
TMPRSS9 and GRIN2B are associated with neuroticism: a genome-wide association study in a European sample.


dbdate: 2013-03-15
author: Ramsey LB
date: 2012-12-11
journal: Blood
link: http://www.ncbi.nlm.nih.gov/pubmed/23233662
study: Genome-wide study of methotrexate clearance replicates SLCO1B1.
trait: Methotrexate clearance (acute lymphoblastic leukemia)
replication_samplesize: 699 European ancestry cases
region: 12p12.1
chrom: 12
reported_genes: SLCO1B1
mapped_gene: SLCO1B1
snp_gene_ids: 10599
strongest_risk_snp: rs4149080
strongest_risk_allele: C
snps: rs4149080
snp_id_current: 4149080
context: intron
pvalue_mlog: 20.22184874961635
ci_95: [NR] mL/min/m2 decrease
platform: Affymetrix [~5.2 Million] (imputed)
cnv: N
initial_samplesize:
22 East Asian ancestry cases, 58 African ancestry, African American, or Afro-Caribbean ancestry cases, 266 Hispanic, or Latin American ancestry cases, 806 European ancestry cases, 127 other ancestry cases


dbdate: 2012-12-16
author: Hou S
date: 2012-12-06
journal: Arthritis Rheum
link: http://www.ncbi.nlm.nih.gov/pubmed/23001997
trait: Behcet's disease
initial_samplesize: 147 Han Chinese ancestry cases, 951 Han Chinese ancestry controls
replication_samplesize: 554 Han Chinese ancestry cases, 1,159 Han Chinese ancestry controls
region: 2q14.2
chrom: 2
reported_genes: TFCP2L1
mapped_gene: TFCP2L1
snp_gene_ids: 29842
strongest_risk_snp: rs17006292
snps: rs17006292
snp_id_current: 17006292
context: intron
pvalue_mlog: 8.301029995663981
ci_95: [2.50-5.00]
platform: Affyemtrix [661,736]
cnv: N
study:
Identification of a susceptibility locus in STAT4 for Beh&#x000e7;et's disease in Han Chinese in a genome-wide association study.


dbdate: 2013-02-08
author: Le Clerc S
date: 2012-12-06
journal: J Invest Dermatol
link: http://www.ncbi.nlm.nih.gov/pubmed/23223146
trait: Aging (facial)
initial_samplesize: 502 European ancestry women
region: 3q13.33
chrom: 3
reported_genes: STXBP5L, FBXO40
mapped_gene: NAP1L1P3 - STXBP5L
upstream_gene_id: 100130335
downstream_gene_id: 9515
strongest_risk_snp: rs322458
strongest_risk_allele: G
snps: rs322458
snp_id_current: 322458
context: Intergenic
pvalue_mlog: 7.698970004336018
platform: Illumina [795,063]
cnv: N
study:
A genome-wide association study in Caucasian women points out a putative role of the STXBP5L gene in facial photoaging.


dbdate: 2013-03-05
author: Zuo L
date: 2012-12-06
journal: Alcohol Clin Exp Res
link: http://www.ncbi.nlm.nih.gov/pubmed/23216389
trait: Alcohol and nictotine co-dependence
initial_samplesize: 818 European ancestry cases, 1,396 European ancestry controls
region: 5q12.1
chrom: 5
reported_genes: HTR1A, IPO11
mapped_gene: ISCA1P1 - HTR1A
upstream_gene_id: 389293
downstream_gene_id: 3350
strongest_risk_snp: rs7445832
strongest_risk_allele: A
snps: rs7445832
snp_id_current: 7445832
context: Intergenic
pvalue_mlog: 8.999999999999998
ci_95: [NR]
platform: Illumina [805,814]
cnv: N
study:
Genome-wide significant association signals in IPO11-HTR1A region specific for alcohol and nicotine codependence.

replication_samplesize:
Up to 907 European ancestry cases, up to 2,830 European ancestry controls, up to 449 African American cases, up to 480 African American controls


dbdate: 2013-02-20
author: Adams LA
date: 2012-12-05
journal: Hepatology
link: http://www.ncbi.nlm.nih.gov/pubmed/23213074
trait: Non-alcoholic fatty liver disease histology (other)
initial_samplesize: 126 European ancestry adolescent cases, 802 European ancestry adolescent controls
region: 1p21.2
chrom: 1
reported_genes: LPPR4
mapped_gene: LPPR4 - PALMD
upstream_gene_id: 9890
downstream_gene_id: 54873
strongest_risk_snp: rs12743824
strongest_risk_allele: C
snps: rs12743824
snp_id_current: 12743824
context: Intergenic
pvalue_mlog: 5.301029995663981
ci_95: [-0.05200-4.65200]
platform: Illumina [2,078,805] (imputed)
cnv: N
study:
Association between liver-specific gene polymorphisms and their expression levels with nonalcoholic fatty liver disease.


dbdate: 2013-04-09
author: Comuzzie AG
date: 2012-12-04
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/23251661
trait: Obesity-related traits
initial_samplesize: 815 Hispanic children from 263 families
region: 1q31.3
chrom: 1
reported_genes: EEF1A1P14
mapped_gene: EEF1A1P14 - KCNT2
upstream_gene_id: 647167
downstream_gene_id: 343450
strongest_risk_snp: rs3001167
strongest_risk_allele: G
snps: rs3001167
snp_id_current: 3001167
context: Intergenic
pvalue_mlog: 5.522878745280337
ci_95: [NR] ng/mL increase
platform: Illumina [899,892]
cnv: N
study:
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.


dbdate: 2013-03-05
author: Lasky-Su J
date: 2012-12-04
journal: Clin Exp Allergy
link: http://www.ncbi.nlm.nih.gov/pubmed/23181788
trait: Asthma
initial_samplesize: Up to 1,238 European ancestry cases, up to 2,617 European ancestry controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DQA1
mapped_gene: HLA-DQA1
snp_gene_ids: 3117
strongest_risk_snp: rs9272346
snps: rs9272346
snp_id_current: 9272346
context: nearGene-5
pvalue_mlog: 7.698970004336018
platform: Affymetrix (455,089)
cnv: N
study:
HLA-DQ strikes again: genome-wide association study further confirms HLA-DQ in the diagnosis of asthma among adults.

replication_samplesize:
Up to 1,837 European ancestry cases, up to 3,803 European ancestry controls, up to 2,806 cases, up to 2,150 controls, up to 603 Costa Rican ancestry cases and their parents


dbdate: 2013-03-05
author: Sprooten E
date: 2012-12-04
journal: Psychiatry Res
link: http://www.ncbi.nlm.nih.gov/pubmed/23218918
trait: White matter integrity
initial_samplesize: 70 unaffected relatives of patients with bipolar disorder, 80 controls
region: 8p21.2
chrom: 8
reported_genes: ADAM7
mapped_gene: ADAM7 - NEFM
upstream_gene_id: 8756
downstream_gene_id: 4741
strongest_risk_snp: rs11781622
snps: rs11781622
snp_id_current: 11781622
context: Intergenic
pvalue_mlog: 5.522878745280337
platform: Illumina (565,404)
cnv: N
study:
White matter integrity as an intermediate phenotype: exploratory genome-wide association analysis in individuals at high risk of bipolar disorder.


dbdate: 2013-03-19
author: Tabassum R
date: 2012-12-03
journal: Diabetes
link: http://www.ncbi.nlm.nih.gov/pubmed/23209189
trait: Type 2 diabetes
initial_samplesize: 1,101 Indo-European ancestry cases, 1,027 Indo-European ancestry controls
region: 2q21.3
chrom: 2
reported_genes: TMEM163
mapped_gene: TMEM163 - ACMSD
upstream_gene_id: 81615
downstream_gene_id: 130013
strongest_risk_snp: rs6723108
strongest_risk_allele: T
snps: rs6723108
snp_id_current: 6723108
context: Intergenic
pvalue_mlog: 7.154901959985742
ci_95: [1.17-1.39]
platform: Illumina [536,420]
cnv: N
study:
Genome-wide association study for type 2 diabetes in Indians identifies a new susceptibility locus at 2q21.

replication_samplesize:
3,607 Indo-European ancestry cases, 2,924 Indo-European ancestry controls, 1,184 Dravidian ancestry cases, 1,061 Dravidian ancestry controls, 11,285 European ancestry cases, 11,285 European ancestry controls


dbdate: 2013-02-28
author: Horikoshi M
date: 2012-12-02
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23202124
trait: Birth weight
initial_samplesize: Up to 26,836 European ancestry individuals
replication_samplesize: Up to 42,519 European ancestry individuals
region: 3q25.31
chrom: 3
reported_genes: CCNL1
mapped_gene: KLF3P2 - LINC00880
upstream_gene_id: 100124394
downstream_gene_id: 339894
strongest_risk_snp: rs900400
strongest_risk_allele: C
snps: rs900400
snp_id_current: 900400
context: Intergenic
pvalue_mlog: 37.39794000867204
ci_95: [0.060-0.084] gram decrease
platform: Illumina & Affymetrix (~2.7 million) imputed
cnv: N
study:
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.


dbdate: 2013-02-20
author: Fanous AH
date: 2012-12-01
journal: Am J Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/23212062
trait: Schizophrenia
initial_samplesize: 2,454 European ancestry cases
region: 18q23
chrom: 18
reported_genes: CTDP1, CTD
mapped_gene: NFATC1 - FLJ25715
upstream_gene_id: 4772
downstream_gene_id: 284241
strongest_risk_snp: rs7233060
snps: rs7233060
snp_id_current: 7233060
context: Intergenic
pvalue_mlog: 6.522878745280337
ci_95: [NR] unit increase
platform: Affymetrix [696,491]
cnv: N
study:
Genome-wide association study of clinical dimensions of schizophrenia: polygenic effect on disorganized symptoms.


dbdate: 2013-02-14
author: Velez Edwards DR
date: 2012-11-29
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23192594
trait: Body mass index (interaction)
initial_samplesize: 8,203 African American women, 3,484 Hispanic ancestry women
region: 14q22.3
chrom: 14
reported_genes: LOC645687, PELI2
mapped_gene: LINC00520 - PELI2
upstream_gene_id: 645687
downstream_gene_id: 57161
strongest_risk_snp: rs7350721
strongest_risk_allele: C
snps: rs7350721
snp_id_current: 7350721
context: Intergenic
pvalue_mlog: 6.221848749616355
ci_95: [0.25-0.58] unit increase
platform: Affymetrix [706,791]
cnv: N
study:
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.


dbdate: 2013-02-06
author: Deo R
date: 2012-11-23
journal: Heart Rhythm
link: http://www.ncbi.nlm.nih.gov/pubmed/23183192
trait: Resting heart rate
initial_samplesize: 13,372 African American individuals
region: 6q22.31
chrom: 6
reported_genes: GJA1, HMGB3P18
mapped_gene: RPL23AP48 - HMGB3P18
upstream_gene_id: 728567
downstream_gene_id: 644502
strongest_risk_snp: rs9320841
snps: rs9320841
snp_id_current: 9320841
context: Intergenic
pvalue_mlog: 14.30102999566398
ci_95: [9.67-16.33] ms increase
platform: Illumina & Affymetrix [2,954,965] (imputed)
cnv: N
study:
Common genetic variation near the connexin-43 gene is associated with resting heart rate in African Americans: a genome-wide association study of 13,372 participants.


dbdate: 2013-01-30
author: Justice CM
date: 2012-11-18
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23160099
trait: Sagittal craniosynostosis
initial_samplesize: 130 European ancestry trios
replication_samplesize: 172 Other ancestry cases, 548 Other ancestry controls
region: 20p12.3
chrom: 20
reported_genes: BMP2
mapped_gene: BMP2 - MIR8062
upstream_gene_id: 650
downstream_gene_id: 102465865
strongest_risk_snp: rs1884302
strongest_risk_allele: C
snps: rs1884302
snp_id_current: 1884302
context: Intergenic
pvalue_mlog: 38.99999999999999
ci_95: [3.51-5.45]
platform: Illumina [915,307]
cnv: N
study:
A genome-wide association study identifies susceptibility loci for nonsyndromic sagittal craniosynostosis near BMP2 and within BBS9.


dbdate: 2014-02-13
author: Jonsson T
date: 2012-11-14
journal: N Engl J Med
link: http://www.ncbi.nlm.nih.gov/pubmed/23150908
study: Variant of TREM2 associated with the risk of Alzheimer's disease.
trait: Alzheimer's disease
initial_samplesize: 3,550 European ancestry cases, 8,888 European ancestry controls
region: 6p21.1
chrom: 6
reported_genes: TREM2
mapped_gene: TREM2
snp_gene_ids: 54209
strongest_risk_snp: rs75932628
strongest_risk_allele: T
snps: rs75932628
snp_id_current: 75932628
context: missense
pvalue_mlog: 11.69897000433602
ci_95: [2.16-3.91]
cnv: N
replication_samplesize:
694 European ancestry cases, 4,375 European ancestry controls, 1,343 Other ancestry cases, 5,352 Other ancestry controls


dbdate: 2013-02-01
author: Lan Q
date: 2012-11-11
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23143601
trait: Lung cancer
initial_samplesize: 5,510 East Asian ancestry cases, 4,544 East Asian ancestry controls
replication_samplesize: 1,099 East Asian ancestry cases, 2,913 East Asian ancestry controls
region: 3q28
chrom: 3
reported_genes: TP63
mapped_gene: TP63
snp_gene_ids: 8626
strongest_risk_snp: rs4488809
strongest_risk_allele: C
snps: rs4488809
snp_id_current: 4488809
context: intron
pvalue_mlog: 8.397940008672036
ci_95: [1.12-1.26]
platform: Illumina [596,032]
cnv: N
study:
Genome-wide association analysis identifies new lung cancer susceptibility loci in never-smoking women in Asia.


dbdate: 2013-01-23
author: Whitcomb DC
date: 2012-11-11
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23143602
trait: Pancreatitis
initial_samplesize: 676 European ancestry cases, 4,507 European ancestry controls
replication_samplesize: 910 European ancestry cases, 4,170 European ancestry controls
region: 7q34
chrom: 7
reported_genes: PRSS1, PRSS2
mapped_gene: PRSS1
snp_gene_ids: 5644
strongest_risk_snp: rs10273639
strongest_risk_allele: C
snps: rs10273639
snp_id_current: 10273639
context: nearGene-5
pvalue_mlog: 13.69897000433602
ci_95: [1.30-1.42]
platform: Illumina (625,739)
cnv: N
study:
Common genetic variants in the CLDN2 and PRSS1-PRSS2 loci alter risk for alcohol-related and sporadic pancreatitis.


dbdate: 2013-01-29
author: Aslibekyan S
date: 2012-11-10
journal: Nutr Metab Cardiovasc Dis
link: http://www.ncbi.nlm.nih.gov/pubmed/23149075
trait: Response to fenofibrate (adiponectin levels)
initial_samplesize: 793 European ancestry individuals
region: 20q13.31
chrom: 20
reported_genes: PMEPA1, PCK1, ZBP1
mapped_gene: PMEPA1 - MIR4532
upstream_gene_id: 56937
downstream_gene_id: 100616353
strongest_risk_snp: rs12481680
snps: rs12481680
snp_id_current: 12481680
context: Intergenic
pvalue_mlog: 6.698970004336019
ci_95: [0.14-0.30] ng/dL increase
platform: Affymterix [2,543,887] (imputed)
cnv: N
study:
Preliminary evidence of genetic determinants of adiponectin response to fenofibrate in the Genetics of Lipid Lowering Drugs and Diet Network.


dbdate: 2013-02-06
author: Levin AM
date: 2012-11-10
journal: J Allergy Clin Immunol
link: http://www.ncbi.nlm.nih.gov/pubmed/23146381
trait: IgE levels
initial_samplesize: 2,469 African American individuals, 259 Latino individuals, 1,564 European ancestry individuals
region: 3p14.1
chrom: 3
reported_genes: SUCLG2
mapped_gene: SUCLG2
snp_gene_ids: 8801
strongest_risk_snp: rs2363709
strongest_risk_allele: G
snps: rs2363709
snp_id_current: 2363709
context: intron
pvalue_mlog: 5.301029995663981
ci_95: [0.07-0.17] unit decrease
platform: Affymetrix and Illumina [NR] (imputed)
cnv: N
study:
A meta-analysis of genome-wide association studies for serum total IgE in diverse study populations.

replication_samplesize:
2,961 African American individuals, 1,477 Latino individuals, 649 European ancestry individuals, 680 Hutterites


dbdate: 2013-01-18
author: Butler AM
date: 2012-11-08
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23139255
trait: PR interval
initial_samplesize: 13,415 African American individuals
region: 2p14
chrom: 2
reported_genes: MEIS1
mapped_gene: MEIS1
snp_gene_ids: 4211
strongest_risk_snp: rs3891585
strongest_risk_allele: A
snps: rs3891585
snp_id_current: 3891585
context: intron
pvalue_mlog: 11
ci_95: [1.52-2.74] unit increase
platform: Affymetrix & Illumina [2,845,108] (imputed)
cnv: N
study:
Novel loci associated with PR interval in a genome-wide association study of 10 African American cohorts.


dbdate: 2013-01-25
author: Lee Y
date: 2012-11-08
journal: Carcinogenesis
link: http://www.ncbi.nlm.nih.gov/pubmed/23144319
trait: Non-small cell lung cancer
initial_samplesize: 348 Korean ancestry cases
region: 9p22.1
chrom: 9
reported_genes: FAM154A
mapped_gene: FAM154A
snp_gene_ids: 158297
strongest_risk_snp: rs1571228
snps: rs1571228
snp_id_current: 1571228
context: intron
pvalue_mlog: 6.698970004336019
platform: Affymetrix [271,817]
cnv: N
study:
Prognostic implications of genetic variants in advanced non-small cell lung cancer: a genome-wide association study.


dbdate: 2013-01-23
author: Betcheva ET
date: 2012-11-07
journal: Psychiatr Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23142968
trait: Schizophrenia
initial_samplesize: 188 European ancestry cases, 376 European ancestry controls
replication_samplesize: 99 European ancestry cases, 328 European ancestry controls
region: 1q32.2
chrom: 1
reported_genes: HHAT
mapped_gene: HHAT
snp_gene_ids: 55733
strongest_risk_snp: rs7527939
strongest_risk_allele: C
snps: rs7527939
snp_id_current: 7527939
context: intron
pvalue_mlog: 8.221848749616356
ci_95: [1.89-3.66]
platform: Illumina [495,089]
cnv: N
study:
Whole-genome-wide association study in the Bulgarian population reveals HHAT as schizophrenia susceptibility gene.


dbdate: 2013-01-22
author: Brown CC
date: 2012-11-01
journal: Pharmacogenet Genomics
link: http://www.ncbi.nlm.nih.gov/pubmed/23047291
trait: Response to temozolomide
initial_samplesize: 516 European ancestry lymphoblastoid cell lines
region: 10q26.3
chrom: 10
reported_genes: MGMT
mapped_gene: MGMT
snp_gene_ids: 4255
strongest_risk_snp: rs477692
snps: rs477692
snp_id_current: 477692
context: intron
pvalue_mlog: 8
platform: Illumina [2,074,734] (imputed)
cnv: N
study:
A genome-wide association analysis of temozolomide response using lymphoblastoid cell lines shows a clinically relevant association with MGMT.


dbdate: 2013-01-30
author: Chu AY
date: 2012-11-01
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23118302
trait: Lipoprotein-associated phospholipase A2 activity and mass
initial_samplesize: 6,851 European ancestry individuals
replication_samplesize: 13,664 European ancestry individuals
region: 2p23.3
chrom: 2
reported_genes: GCKR
mapped_gene: GCKR
snp_gene_ids: 2646
strongest_risk_snp: rs1260326
strongest_risk_allele: T
snps: rs1260326
snp_id_current: 1260326
context: missense
pvalue_mlog: 5.301029995663981
ci_95: [-0.00215-0.01275] ng/ml decrease
platform: Illumina [796,174]
cnv: N
study:
Genome-wide association study evaluating lipoprotein-associated phospholipase A2 mass and activity at baseline and after rosuvastatin therapy.


dbdate: 2013-01-11
author: Candille SI
date: 2012-10-31
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/23118974
trait: Eye color
initial_samplesize: 175 European ancestry individuals
replication_samplesize: 293 European ancestry individuals
region: 15q13.1
chrom: 15
reported_genes: HERC2, OCA2
mapped_gene: HERC2
snp_gene_ids: 8924
strongest_risk_snp: rs1667394
strongest_risk_allele: C
snps: rs1667394
snp_id_current: 1667394
context: intron
pvalue_mlog: 19.69897000433602
ci_95: [0.28-0.42] unit increase
platform: Illumina [313,763]
cnv: N
study:
Genome-wide association studies of quantitatively measured skin, hair, and eye pigmentation in four European populations.


dbdate: 2013-01-11
author: Yang M
date: 2012-10-31
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/23118916
trait: IgM levels
initial_samplesize: 1,999 Han Chinese ancestry individuals
replication_samplesize: 1,496 East Asian ancestry individuals
region: 17p13.1
chrom: 17
reported_genes: TNFSF13
mapped_gene: TNFSF13;TNFSF12-TNFSF13
snp_gene_ids: 8741;407977
strongest_risk_snp: rs11552708
strongest_risk_allele: G
snps: rs11552708
snp_id_current: 11552708
context: missense;intron
pvalue_mlog: 8.397940008672036
platform: Illumina [1,940,243] (imputed)
cnv: N
study:
Genome-wide scan identifies variant in TNFSF13 associated with serum IgM in a healthy Chinese male population.


dbdate: 2013-01-16
author: Guo YF
date: 2012-10-30
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23108985
trait: Body mass (lean)
initial_samplesize: 1,627 Han Chinese individuals
replication_samplesize: 2,286 European ancestry individuals
region: 11q12.1
chrom: 11
reported_genes: GLYAT
mapped_gene: CNTF - GLYAT
upstream_gene_id: 1270
downstream_gene_id: 10249
strongest_risk_snp: rs2507838
strongest_risk_allele: A
snps: rs2507838
snp_id_current: 2507838
context: Intergenic
pvalue_mlog: 7.698970004336018
platform: Affymetrix [689,368]
cnv: N
study:
Suggestion of GLYAT gene underlying variation of bone size and body lean mass as revealed by a bivariate genome-wide association study.


dbdate: 2013-01-15
author: Wang LE
date: 2012-10-29
journal: Cancer Res
link: http://www.ncbi.nlm.nih.gov/pubmed/23108145
trait: Lung Cancer (DNA repair capacity)
initial_samplesize: 914 European ancestry non-small cell lung cancer cases, 860 European ancestry controls
replication_samplesize: 679 European ancestry ancestry non-small cell lung cancer cases, 695 European ancestry controls
region: 19q13.32
chrom: 19
reported_genes: ERCC2, XPD
mapped_gene: ERCC2;KLC3
snp_gene_ids: 2068;147700
strongest_risk_snp: rs13181
strongest_risk_allele: C
snps: rs13181
snp_id_current: 13181
context: missense;nearGene-3
pvalue_mlog: 6.045757490560675
platform: Illumina [303,669]
cnv: N
study:
Genome-wide association study reveals novel genetic determinants of DNA repair capacity in lung cancer.


dbdate: 2013-01-11
author: Nyholt DR
date: 2012-10-28
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23104006
study: Genome-wide association meta-analysis identifies new endometriosis risk loci.
trait: Endometriosis
replication_samplesize: 1,044 Japanese ancestry, 4,017 Japanese ancestry controls
region: 1p36.12
chrom: 1
reported_genes: WNT4
mapped_gene: WNT4 - MIR4418
upstream_gene_id: 54361
downstream_gene_id: 100616433
strongest_risk_snp: rs7521902
strongest_risk_allele: A
snps: rs7521902
snp_id_current: 7521902
context: Intergenic
pvalue_mlog: 10.52287874528034
ci_95: [1.13-1.25]
platform: Illumina [407,632]
cnv: N
initial_samplesize:
3,181 European ancestry cases, 8,075 European ancestry controls, 1,423 Japanese ancestry cases, 1,318 Japanese ancestry controls


dbdate: 2013-01-18
author: Jin G
date: 2012-10-25
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23103227
study: Genetic variants at 6p21.1 and 7p15.3 are associated with risk of multiple cancers in Han Chinese.
trait: Multiple cancers (lung cancer, gastric cancer, and squamous cell carcinoma)
region: 6p21.1
chrom: 6
reported_genes: LRFN2
mapped_gene: LRFN2
snp_gene_ids: 57497
strongest_risk_snp: rs2494938
strongest_risk_allele: A
snps: rs2494938
snp_id_current: 2494938
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [1.08-1.22]
platform: Affymetrix [NR]
cnv: N
initial_samplesize:
2,331 Han Chinese ancestry lung cancer cases, 1,006 Han Chinese ancestry non-cardia gastric cancer cases, 2,031 Han Chinese ancestry esophageal squamous-cell carcinoma cases, 4,006 Han Chinese ancestry controls

replication_samplesize:
2,665 Han Chinese ancestry lung cancer cases, 3,330 Han Chinese ancestry non-cardia gastric cancer cases, 3,006 Han Chinese ancestry esophageal squamous-cell carcinoma cases, 11,436 Han Chinese ancestry controls


dbdate: 2013-01-10
author: Amin Al Olama A
date: 2012-10-12
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23065704
trait: Prostate cancer
region: 19q13.2
chrom: 19
reported_genes: ATP5SL, CEACAM21
mapped_gene: PCAT19
snp_gene_ids: 100505495
strongest_risk_snp: rs11672691
strongest_risk_allele: G
snps: rs11672691
snp_id_current: 11672691
context: intron
pvalue_mlog: 8
ci_95: [1.02-1.20]
platform: Illumina [~2.6 million] (imputed)
cnv: N
study:
A meta-analysis of genome-wide association studies to identify prostate cancer susceptibility loci associated with aggressive and non-aggressive disease.

initial_samplesize:
5,132 European ancestry non-aggressive cases, 5,953 European ancestry aggressive cases, 11,463 European ancestry controls

replication_samplesize:
22,387 European ancestry non-aggressive cases, 2,008 European ancestry aggressive cases, up to 24,726 European ancestry controls


dbdate: 2013-01-16
author: Meng W
date: 2012-10-09
journal: Invest Ophthalmol Vis Sci
link: http://www.ncbi.nlm.nih.gov/pubmed/23049088
trait: Myopia (pathological)
initial_samplesize: 187 European ancestry cases, 1064 European ancestry controls
region: 8p23.1
chrom: 8
reported_genes: PPP1R3B, MYP10, MIR4660, MIR124-1, MSRA
mapped_gene: MIR4660 - PPP1R3B
upstream_gene_id: 100616350
downstream_gene_id: 79660
strongest_risk_snp: rs189798
snps: rs189798
snp_id_current: 189798
context: Intergenic
pvalue_mlog: 6.221848749616355
ci_95: [NR]
platform: Affymetrix & Illumina [152,234]
cnv: N
study:
A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population.


dbdate: 2012-12-21
author: Hirota T
date: 2012-10-07
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23042114
trait: Atopic dermatitis
initial_samplesize: 1,472 Japanese ancestry cases, 7,971 Japanese ancestry controls
replication_samplesize: 1,856 Japanese ancestry cases, 7,021 Japanese ancestry controls
region: 2q12.1
chrom: 2
reported_genes: IL1RL1, IL18R1, IL18RAP
mapped_gene: IL18R1
snp_gene_ids: 8809
strongest_risk_snp: rs13015714
strongest_risk_allele: G
snps: rs13015714
snp_id_current: 13015714
context: nearGene-5
pvalue_mlog: 17.09691001300806
ci_95: [1.20-1.34]
platform: Illumina [606,164]
cnv: N
study:
Genome-wide association study identifies eight new susceptibility loci for atopic dermatitis in the Japanese population.


dbdate: 2013-01-09
author: Lee YH
date: 2012-10-07
journal: Mol Biol Rep
link: http://www.ncbi.nlm.nih.gov/pubmed/23053960
trait: Systemic lupus erythematosus
initial_samplesize: 1,527 European ancestry cases, 3,421 European ancestry controls,
region: 2q32.3
chrom: 2
reported_genes: STAT4
mapped_gene: STAT4
snp_gene_ids: 6775
strongest_risk_snp: rs7574865
strongest_risk_allele: T
snps: rs7574865
snp_id_current: 7574865
context: intron
pvalue_mlog: 13.39794000867204
ci_95: [1.335-1.634]
platform: Illumina [737,984]
cnv: N
study:
Genome-wide pathway analysis of genome-wide association studies on systemic lupus erythematosus and rheumatoid arthritis.


dbdate: 2013-01-09
author: Traylor M
date: 2012-10-05
journal: Lancet Neurol
link: http://www.ncbi.nlm.nih.gov/pubmed/23041239
trait: Stroke (ischemic)
initial_samplesize: 12,389 European ancestry cases, 62,004 European ancestry controls
region: 7p21.1
chrom: 7
reported_genes: HDAC9
mapped_gene: TWIST1
snp_gene_ids: 7291
strongest_risk_snp: rs2107595
strongest_risk_allele: A
snps: rs2107595
snp_id_current: 2107595
context: intron
pvalue_mlog: 5.397940008672037
ci_95: [1.07-1.17]
platform: Affymetrix & Illumina [NR] (imputed)
cnv: N
study:
Genetic risk factors for ischaemic stroke and its subtypes (the METASTROKE collaboration): a meta-analysis of genome-wide association studies.

replication_samplesize:
1,322 Pakistani ancestry cases, 1,143 Pakistani ancestry controls, 12,025 European ancestry cases, 27,940 European ancestry controls


dbdate: 2012-12-21
author: Surakka I
date: 2012-10-03
journal: Twin Res Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23031429
trait: Apolipoprotein Levels
initial_samplesize: 1,720 European ancestry monozygotic twins
region: 10q26.2
chrom: 10
reported_genes: DOCK1
mapped_gene: DOCK1
snp_gene_ids: 1793
strongest_risk_snp: rs9733352
strongest_risk_allele: C
snps: rs9733352
snp_id_current: 9733352
context: intron
pvalue_mlog: 7.397940008672037
ci_95: [0.038-0.082] unit increase
platform: Illumina [~2.5 million] (imputed)
cnv: N
study:
A genome-wide association study of monozygotic twin-pairs suggests a locus related to variability of serum high-density lipoprotein cholesterol.


dbdate: 2012-12-11
author: Xu J
date: 2012-09-30
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23023329
trait: Prostate cancer
initial_samplesize: 1,417 Han Chinese ancestry cases, 1,008 Han Chinese ancestry controls
replication_samplesize: 3,067 Han Chinese ancestry cases, 7,926 Han Chinese ancestry controls
region: 9q31.2
chrom: 9
reported_genes: RAD23B, KLF4
mapped_gene: RAD23B - HMGN2P32
upstream_gene_id: 5887
downstream_gene_id: 100874473
strongest_risk_snp: rs817826
strongest_risk_allele: C
snps: rs817826
snp_id_current: 817826
context: Intergenic
pvalue_mlog: 13.30102999566398
ci_95: [1.29-1.54]
platform: Illumina [587,294]
cnv: N
study:
Genome-wide association study in Chinese men identifies two new prostate cancer risk loci at 9q31.2 and 19q13.4.


dbdate: 2012-12-07
author: Ramasamy A
date: 2012-09-28
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/23028483
trait: Asthma
initial_samplesize: 1,716 European ancestry cases, 16,888 European ancestry controls
replication_samplesize: 4,035 European ancestry cases, 11,251 European ancestry controls
region: 2q12.1
chrom: 2
reported_genes: IL1RL1, IL18R1
mapped_gene: IL1RL1
snp_gene_ids: 9173
strongest_risk_snp: rs13408661
strongest_risk_allele: G
snps: rs13408661
snp_id_current: 13408661
context: intron
pvalue_mlog: 8.999999999999998
ci_95: [1.15-1.31]
platform: Affymetrix & Ilumina [~2.2 million] (imputed)
cnv: N
study:
Genome-wide association studies of asthma in population-based cohorts confirm known and suggested loci and identify an additional association near HLA.


dbdate: 2012-12-21
author: Kumasaka N
date: 2012-09-25
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/23049750
trait: Smoking behavior
initial_samplesize: 11,696 Japanese ancestry smokers
replication_samplesize: 5,462 Japanese ancestry smokers
region: 19q13.2
chrom: 19
reported_genes: CYP2A6
mapped_gene: CYP2A6 - CYP2A7
upstream_gene_id: 1548
downstream_gene_id: 1549
strongest_risk_snp: rs8102683
snps: rs8102683
snp_id_current: 8102683
context: Intergenic
pvalue_mlog: 41.39794000867203
ci_95: [2.36-3.16] unit increase
platform: Illumina [2,312,503] (imputed)
cnv: N
study:
Haplotypes with copy number and single nucleotide polymorphisms in CYP2A6 locus are associated with smoking quantity in a Japanese population.


dbdate: 2012-12-05
author: Mangino M
date: 2012-09-25
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23001564
trait: Telomere length
initial_samplesize: 9,190 European ancestry individuals
replication_samplesize: 2,226 individuals
region: 19p12
chrom: 19
reported_genes: ZNF676
mapped_gene: VN1R85P - ZNF676
upstream_gene_id: 100312830
downstream_gene_id: 163223
strongest_risk_snp: rs412658
strongest_risk_allele: T
snps: rs412658
snp_id_current: 412658
context: Intergenic
pvalue_mlog: 8
ci_95: [0.032-0.067] unit increase
platform: Affymetrix & Illumina [2.5 million] (imputed)
cnv: N
study:
Genome-wide meta-analysis points to CTC1 and ZNF676 as genes regulating telomere homeostasis in humans.


dbdate: 2012-12-06
author: Niu N M D Ph D
date: 2012-09-24
journal: BMC Cancer
link: http://www.ncbi.nlm.nih.gov/pubmed/23006423
trait: Response to taxane treatment (docetaxel)
region: 1p31.1
chrom: 1
reported_genes: TTLL7
mapped_gene: ST13P20 - ARF4P5
upstream_gene_id: 729828
downstream_gene_id: 100316867
strongest_risk_snp: rs10874322
snps: rs10874322
snp_id_current: 10874322
context: Intergenic
pvalue_mlog: 5.698970004336018
platform: Affymetrix & Illumina [~1.3 Million]
cnv: N
study:
Genetic association with overall survival of taxane-treated lung cancer patients - A genome-wide association study in human lymphoblastoid cell lines followed by a clinical association study.

initial_samplesize:
96 African American lymphoblastoid cell lines, 96 European ancestry lymphoblastoid cell lines, 96 Han Chinese ancestry lymphoblastoid cell lines


dbdate: 2012-12-04
author: Voruganti VS
date: 2012-09-24
journal: Cytokine
link: http://www.ncbi.nlm.nih.gov/pubmed/23017229
trait: Monocyte chemoattractant protein-1
initial_samplesize: 815 Hispanic children
region: 1q23.2
chrom: 1
reported_genes: DARC
mapped_gene: ACKR1
snp_gene_ids: 2532
strongest_risk_snp: rs12075
strongest_risk_allele: A
snps: rs12075
snp_id_current: 12075
context: missense
pvalue_mlog: 21
platform: Ilumina [NR]
cnv: N
study:
Genome-wide association replicates the association of Duffy antigen receptor for chemokines (DARC) polymorphisms with serum monocyte chemoattractant protein-1 (MCP-1) levels in Hispanic children.


dbdate: 2012-12-06
author: Yang JJ
date: 2012-09-24
journal: Blood
link: http://www.ncbi.nlm.nih.gov/pubmed/23007406
trait: Acute lymphoblastic leukemia (childhood)
region: 14q22.1
chrom: 14
reported_genes: PYGL
mapped_gene: PYGL
snp_gene_ids: 5836
strongest_risk_snp: rs7142143
strongest_risk_allele: C
snps: rs7142143
snp_id_current: 7142143
context: intron
pvalue_mlog: 8.154901959985743
ci_95: [2.34-5.57]
platform: Affymetrix [444,044]
cnv: N
study:
Genome-wide association study identifies germline polymorphisms associated with relapse of childhood acute lymphoblastic leukemia.

initial_samplesize:
1,268 cases of European, South Asian, East Asian, African American/Afro-Caribbean, Hispanic and other ancestries

replication_samplesize:
1,267 cases of European, South Asian, East Asian, African American/Afro-Caribbean, Hispanic and other ancestries


dbdate: 2012-12-02
author: Orr N
date: 2012-09-23
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23001122
trait: Breast cancer (male)
initial_samplesize: 823 European ancestry cases, 2,795 European ancestry controls
replication_samplesize: 438 European ancestry cases, 474 European ancestry controls
region: 1p31.1
chrom: 1
reported_genes: PRKACB
mapped_gene: PRKACB;LOC101927611
snp_gene_ids: 5567;101927611
strongest_risk_snp: rs903263
snps: rs903263
snp_id_current: 903263
context: intron;intron
pvalue_mlog: 5.999999999999999
ci_95: [1.10-1.34]
platform: Illumina [447,760]
cnv: N
study:
Genome-wide association study identifies a common variant in RAD51B associated with male breast cancer risk.


dbdate: 2012-12-04
author: Arning A
date: 2012-09-20
journal: Blood
link: http://www.ncbi.nlm.nih.gov/pubmed/22990015
trait: Stroke (pediatric)
initial_samplesize: 270 European ancestry trios
region: 11q23.3
chrom: 11
reported_genes: TRIM29
mapped_gene: TRIM29 - OAF
upstream_gene_id: 23650
downstream_gene_id: 220323
strongest_risk_snp: rs2084898
strongest_risk_allele: A
snps: rs2084898
snp_id_current: 2084898
context: Intergenic
pvalue_mlog: 6.397940008672037
ci_95: [NR]
platform: Illumina [334,581]
cnv: N
study:
A genome-wide association study identifies a gene network of ADAMTS genes in the predisposition to pediatric stroke.


dbdate: 2012-12-11
author: Sandholm N
date: 2012-09-20
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23028342
study: New susceptibility loci associated with kidney disease in type 1 diabetes.
trait: Type 1 diabetes nephropathy
region: 2q34
chrom: 2
reported_genes: ERBB4
mapped_gene: ERBB4
snp_gene_ids: 2066
strongest_risk_snp: rs7588550
strongest_risk_allele: A
snps: rs7588550
snp_id_current: 7588550
context: intron
pvalue_mlog: 6.698970004336019
ci_95: [1.30-1.79]
platform: Affymetrix & Illumina [~2.5 Million] (imputed)
cnv: N
initial_samplesize:
Up to 2,916 European ancestry Type 1 Diabetes cases with nephropathy, 3,315 European ancestry Type 1 Diabetes cases without nephropathy

replication_samplesize:
Up to 1,493 European ancestry Type 1 Diabetes cases with nephropathy, 3,191 European ancestry Type 1 Diabetes cases without nephropathy


dbdate: 2012-12-06
author: Williams FM
date: 2012-09-19
journal: Ann Rheum Dis
link: http://www.ncbi.nlm.nih.gov/pubmed/22993228
trait: Disc degeneration (lumbar)
initial_samplesize: 4,683 European ancestry individuals
region: 3p26.2
chrom: 3
reported_genes: Intergenic
mapped_gene: CRBN - SUMF1
upstream_gene_id: 51185
downstream_gene_id: 285362
strongest_risk_snp: rs17034687
strongest_risk_allele: C
snps: rs17034687
snp_id_current: 17034687
context: Intergenic
pvalue_mlog: 8.698970004336019
ci_95: [0.16-0.30] unit increase
platform: Affymetrix & Illumina [2,552,511] (imputed)
cnv: N
study:
Novel genetic variants associated with lumbar disc degeneration in northern Europeans: a meta-analysis of 4600 subjects.


dbdate: 2012-11-28
author: Huang J
date: 2012-09-18
journal: Blood
link: http://www.ncbi.nlm.nih.gov/pubmed/22990020
trait: Plasminogen activator inhibitor type 1 levels (PAI-1)
initial_samplesize: 19,599 European ancestry individuals
replication_samplesize: 10,764 European ancestry individuals
region: 3p25.2
chrom: 3
reported_genes: PPARG
mapped_gene: PPARG
snp_gene_ids: 5468
strongest_risk_snp: rs11128603
snps: rs11128603
snp_id_current: 11128603
context: intron
pvalue_mlog: 7.045757490560674
ci_95: [NR] unit increase
platform: Affymetrix & Illumina [2,445,683] (imputed)
cnv: N
study:
Genome-wide association study for circulating levels of PAI-1 provides novel insights into its regulation.


dbdate: 2012-11-29
author: Nakamura M
date: 2012-09-18
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23000144
trait: Primary biliary cirrhosis
initial_samplesize: 487 Japanese ancestry cases, 476 Japanese ancestry controls
replication_samplesize: 787 Japanese ancestry cases, 615 Japanese ancestry controls
region: 9q32
chrom: 9
reported_genes: TNFSF15
mapped_gene: TNFSF15
snp_gene_ids: 9966
strongest_risk_snp: rs4979462
strongest_risk_allele: T
snps: rs4979462
snp_id_current: 4979462
context: intron
pvalue_mlog: 13.52287874528034
ci_95: [1.39-1.76]
platform: Affymetrix [421,245]
cnv: N
study:
Genome-wide association study identifies TNFSF15 and POU2AF1 as susceptibility loci for primary biliary cirrhosis in the Japanese population.


dbdate: 2012-11-28
author: Myouzen K
date: 2012-09-13
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/23028356
trait: Rheumatoid arthritis
initial_samplesize: 2,303 Japanese ancestry cases, 3,380 Japanese ancestry controls
replication_samplesize: 5,604 Japanese ancestry cases, 31,982 Japanese ancestry controls
region: 6p21.1
chrom: 6
reported_genes: NFKBIE
mapped_gene: NFKBIE
snp_gene_ids: 4794
strongest_risk_snp: rs2233434
strongest_risk_allele: G
snps: rs2233434
snp_id_current: 2233434
context: missense
pvalue_mlog: 15
ci_95: [1.15-1.26]
platform: Illumina [NR]
cnv: N
study:
Functional variants in NFKBIE and RTKN2 involved in activation of the NF-&#x003ba;B pathway are associated with rheumatoid arthritis in Japanese.


dbdate: 2012-11-30
author: Siddiq A
date: 2012-09-13
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22976474
trait: Breast cancer
region: 20q11.22
chrom: 20
reported_genes: RALY, EIF2S2, ASIP
mapped_gene: RALY
snp_gene_ids: 22913
strongest_risk_snp: rs2284378
strongest_risk_allele: T
snps: rs2284378
snp_id_current: 2284378
context: intron
pvalue_mlog: 8
ci_95: [1.10-1.22]
platform: Illumina [2,608,509] (imputed)
cnv: N
study:
A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11.

initial_samplesize:
3,666 European ancestry cases, 28,864 European ancestry controls, 1,004 African American cases, 2,744 African American controls

replication_samplesize:
562 European ancestry cases, 6,410 European ancestry controls, 84 Japanese ancestry cases, 830 Japanese ancestry controls, 300 Latino cases, 1,164 Latino controls


dbdate: 2013-04-09
author: Tang WH
date: 2012-09-13
journal: Arterioscler Thromb Vasc Biol
link: http://www.ncbi.nlm.nih.gov/pubmed/22982463
trait: Paraoxonase activity
initial_samplesize: 2,136 European ancestry individuals
region: 7q21.3
chrom: 7
reported_genes: PON-1
mapped_gene: PON1
snp_gene_ids: 5444
strongest_risk_snp: rs2057681
strongest_risk_allele: G
snps: rs2057681
snp_id_current: 2057681
context: intron
pvalue_mlog: 302.9999999999999
platform: Affymetrix [2,421,770] (Imputed)
cnv: N
study:
Clinical and genetic association of serum paraoxonase and arylesterase activities with cardiovascular risk.


dbdate: 2012-12-11
author: Wu C
date: 2012-09-09
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22960999
trait: Esophageal cancer (alcohol interaction)
initial_samplesize: 2,031 Han Chinese ancestry cases, 2,044 Han Chinese ancestry controls
replication_samplesize: 8,092 Chinese ancestry cases, 8,620 Chinese ancestry controls
region: 4q23
chrom: 4
reported_genes: ADH1B
mapped_gene: ADH1B
snp_gene_ids: 125
strongest_risk_snp: rs1042026
snps: rs1042026
snp_id_current: 1042026
context: UTR-3
pvalue_mlog: 6.522878745280337
ci_95: [1.16-1.38]
cnv: N
study:
Genome-wide association analyses of esophageal squamous cell carcinoma in Chinese identify multiple susceptibility loci and gene-environment interactions.


dbdate: 2013-01-15
author: Buck D
date: 2012-09-08
journal: Ann Neurol
link: http://www.ncbi.nlm.nih.gov/pubmed/23225573
trait: IgG levels
initial_samplesize: 229 European ancestry multiple sclerosis cases
replication_samplesize: 409 European ancestry multiple sclerosis cases
region: 14q32.33
chrom: 14
reported_genes: IGHG3, IGHG1, IGHG2
mapped_gene: IGH
snp_gene_ids: 3492
strongest_risk_snp: rs10136766
strongest_risk_allele: A
snps: rs10136766
snp_id_current: 10136766
pvalue_mlog: 15.09691001300805
ci_95: [NR] unit increase
platform: Illumina [526,014]
cnv: N
study:
Genetic variants in the immunoglobulin heavy chain locus are associated with the IgG index in multiple sclerosis.


dbdate: 2012-11-06
author: Elgazzar S
date: 2012-09-06
journal: J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22951594
trait: Breast cancer
initial_samplesize: 1,086 Japanese ancestry cases, 1,816 Japanese ancestry controls
replication_samplesize: 1,653 Japanese ancestry cases, 2,797 Japanese ancestry controls
region: 3q25.1
chrom: 3
reported_genes: SIAH2
mapped_gene: SIAH2
snp_gene_ids: 6478
strongest_risk_snp: rs6788895
strongest_risk_allele: G
snps: rs6788895
snp_id_current: 6788895
context: intron
pvalue_mlog: 7.045757490560674
ci_95: [1.13-1.31]
platform: Illumina [453,627]
cnv: N
study:
A genome-wide association study identifies a genetic variant in the SIAH2 locus associated with hormonal receptor-positive breast cancer in Japanese.


dbdate: 2012-11-13
author: Foroud T
date: 2012-09-06
journal: Stroke
link: http://www.ncbi.nlm.nih.gov/pubmed/22961961
trait: Intracranial aneurysm
initial_samplesize: 1,483 European ancestry cases, 1,683 European ancestry controls
region: 9p21.3
chrom: 9
reported_genes: CDKN2B-AS1
mapped_gene: CDKN2B-AS1
snp_gene_ids: 100048912
strongest_risk_snp: rs6475606
strongest_risk_allele: T
snps: rs6475606
snp_id_current: 6475606
context: intron
pvalue_mlog: 7.397940008672037
ci_95: [NR]
platform: Axiom & Affymetrix [451,088]
cnv: N
study:
Genome-wide association study of intracranial aneurysms confirms role of Anril and SOX17 in disease risk.


dbdate: 2012-11-15
author: Li H
date: 2012-09-06
journal: Diabetes
link: http://www.ncbi.nlm.nih.gov/pubmed/22961080
trait: Type 2 diabetes
initial_samplesize: 1,839 Han Chinese ancestry cases, 1,873 Han Chinese ancestry controls
region: 10q26.11
chrom: 10
reported_genes: GRK5
mapped_gene: GRK5
snp_gene_ids: 2869
strongest_risk_snp: rs10886471
strongest_risk_allele: C
snps: rs10886471
snp_id_current: 10886471
context: intron
pvalue_mlog: 8.154901959985743
ci_95: [1.08-1.16]
platform: Illumina [2,234,194] (imputed)
cnv: N
study:
A genome-wide association study identifies GRK5 and RASGRP1 as type 2 diabetes loci in Chinese Hans.

replication_samplesize:
15,979 East Asian ancestry cases, 19,360 East Asian ancestry controls, 794 Singaporean Malay ancestry cases, 1,240 Singaporean Malay ancestry controls, 159 South Asian ancestry cases, 1,624 South Asian ancestry controls


dbdate: 2012-11-13
author: Peters MJ
date: 2012-09-06
journal: Ann Rheum Dis
link: http://www.ncbi.nlm.nih.gov/pubmed/22956598
trait: Pain
initial_samplesize: 1,308 European ancestry female cases, 5,791 European ancestry female controls
replication_samplesize: 1,480 European ancestry female cases, 7,989 European ancestry female controls
region: 5p15.2
chrom: 5
reported_genes: CCT5, FAM173B
mapped_gene: TAS2R1 - FAM173B
upstream_gene_id: 50834
downstream_gene_id: 134145
strongest_risk_snp: rs13361160
strongest_risk_allele: C
snps: rs13361160
snp_id_current: 13361160
context: Intergenic
pvalue_mlog: 6.30102999566398
ci_95: [1.10-1.24]
platform: Illumina [2,224,068](imputed)
cnv: N
study:
Genome-wide association study meta-analysis of chronic widespread pain: evidence for involvement of the 5p15.2 region.


dbdate: 2012-11-02
author: EPICURE Consortium
date: 2012-09-04
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22949513
trait: Epilepsy (generalized)
region: 1p34.3
chrom: 1
reported_genes: C1orf94
mapped_gene: C1orf94 - MIR552
upstream_gene_id: 84970
downstream_gene_id: 693137
strongest_risk_snp: rs771390
strongest_risk_allele: C
snps: rs771390
snp_id_current: 771390
context: Intergenic
pvalue_mlog: 6.221848749616355
ci_95: [1.12-1.32]
platform: Affymetrix [4.56 million] (imputed)
cnv: N
study:
Genome-wide association analysis of genetic generalized epilepsies implicates susceptibility loci at 1q43, 2p16.1, 2q22.3 and 17q21.32

initial_samplesize:
702 European ancestry GAE cases, 586 European ancestry JME cases, 239 European ancestry other GGE cases, 2,461 European ancestry controls

replication_samplesize:
347 European ancestry GAE parent-child trios, 166 European ancestry JME parent-child trios, 91 European ancestry other GGE parent-child trios, 385 European ancestry GAE cases, 382 European ancestry JME cases, 122 European ancestry other GGE cases, up to 889 European ancestry controls


dbdate: 2012-11-02
author: Diskin SJ
date: 2012-09-02
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22941191
study: Common variation at 6q16 within HACE1 and LIN28B influences susceptibility to neuroblastoma.
trait: Neuroblastoma
initial_samplesize: 2,101 European ancestry cases, 4,202 European ancestry controls
region: 6q16.3
chrom: 6
reported_genes: HACE1
mapped_gene: HACE1
snp_gene_ids: 57531
strongest_risk_snp: rs4336470
strongest_risk_allele: C
snps: rs4336470
snp_id_current: 4336470
context: intron
pvalue_mlog: 10.52287874528034
ci_95: [1.18-1.35]
platform: Illumina [426,697]
cnv: N
replication_samplesize:
351 European ancestry cases, 780 European ancestry controls, 365 African American cases, 2,491 African American controls


dbdate: 2012-11-02
author: Holliday EG
date: 2012-09-02
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22941190
study: Common variants at 6p21.1 are associated with large artery atherosclerotic stroke.
trait: Stroke (ischemic)
region: 6p21.1
chrom: 6
reported_genes: CDC5L, SUPT3H
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs556621
strongest_risk_allele: A
snps: rs556621
snp_id_current: 556621
pvalue_mlog: 7.30102999566398
ci_95: [1.13-1.30]
platform: Illumina [551,514]
cnv: N
initial_samplesize:
421 European ancestry large artery atherosclerosis cases, 741 European ancestry ischemic stroke cases, 1,244 European ancestry controls

replication_samplesize:
1,715 European ancestry large artery atherosclerosis cases, 9,552 European ancestry ischemic stroke cases, 52,695 European ancestry controls


dbdate: 2012-11-19
author: Cummings AC
date: 2012-09-01
journal: Ann Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22881374
trait: Alzheimer's disease (late onset)
initial_samplesize: 109 Amish cases, 689 Amish controls
region: 1q24.2
chrom: 1
reported_genes: MPZL1
mapped_gene: MPZL1
snp_gene_ids: 9019
strongest_risk_snp: rs4145462
strongest_risk_allele: T
snps: rs4145462
snp_id_current: 4145462
context: intron
pvalue_mlog: 5.999999999999999
platform: Affymetrix [614,963]
cnv: N
study:
Genome-wide association and linkage study in the Amish detects a novel candidate late-onset Alzheimer disease gene.


dbdate: 2012-11-28
author: Levinson DF
date: 2012-09-01
journal: Am J Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/22885689
study: Genome-wide association study of multiplex schizophrenia pedigrees.
trait: Schizophrenia
region: 1q44
chrom: 1
reported_genes: Intergenic
mapped_gene: ZBTB18 - C1orf100
upstream_gene_id: 10472
downstream_gene_id: 200159
strongest_risk_snp: rs10429924
snps: rs10429924
snp_id_current: 10429924
context: Intergenic
pvalue_mlog: 5.999999999999999
ci_95: [NR]
platform: Illumina [up to 531,195]
cnv: N
initial_samplesize:
1,218 European ancestry cases, 990 European ancestry controls, 139 Other ancestry cases, 114 Other ancestry controls


dbdate: 2012-11-05
author: Han Y
date: 2012-08-31
journal: Bone
link: http://www.ncbi.nlm.nih.gov/pubmed/22960237
trait: Comprehensive strength and appendicular lean mass
initial_samplesize: 825 Chinese ancestry females, 802 Chinese ancestry males
replication_samplesize: 1,059 European ancestry males, 2,227 European ancestry females
region: 11q12.2
chrom: 11
reported_genes: FADS1, FADS2
mapped_gene: FADS1
snp_gene_ids: 3992
strongest_risk_snp: rs174547
strongest_risk_allele: C
snps: rs174547
snp_id_current: 174547
context: intron
pvalue_mlog: 6.698970004336019
platform: Affymetrix [701,525]
cnv: N
study:
Bivariate genome-wide association study suggests fatty acid desaturase genes and cadherin DCHS2 for variation of both compressive strength index and appendicular lean mass in males.


dbdate: 2012-10-28
author: Jin G
date: 2012-08-30
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22936694
trait: Androgen levels
initial_samplesize: 3,225 European ancestry males
region: 10q21.3
chrom: 10
reported_genes: JMJD1C
mapped_gene: REEP3
snp_gene_ids: 221035
strongest_risk_snp: rs10822184
strongest_risk_allele: T
snps: rs10822184
snp_id_current: 10822184
context: intron
pvalue_mlog: 8
ci_95: [0.038-0.078] unit decrease
platform: Illumina [642,461]
cnv: N
study:
Genome-wide association study identifies a new locus JMJD1C at 10q21 that may influence serum androgen levels in men.


dbdate: 2012-11-16
author: Julia A
date: 2012-08-30
journal: Gut
link: http://www.ncbi.nlm.nih.gov/pubmed/22936669
trait: Crohn's disease
initial_samplesize: 1,277 European ancestry cases, 1,488 European ancestry controls
replication_samplesize: 1,365 European ancestry cases, 1,396 European ancestry controls
region: 6p21.33
chrom: 6
reported_genes: AIF1
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs9348876
strongest_risk_allele: T
snps: rs9348876
snp_id_current: 9348876
pvalue_mlog: 5.522878745280337
ci_95: [1.22-1.63]
platform: Illumina [508,934]
cnv: N
study:
A genome-wide association study on a southern European population identifies a new Crohn's disease susceptibility locus at RBX1-EP300.


dbdate: 2012-11-05
author: Hart AB
date: 2012-08-28
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/22952603
trait: Response to amphetamines
region: 9q34.12
chrom: 9
reported_genes: ABL1
mapped_gene: ABL1
snp_gene_ids: 25
strongest_risk_snp: rs2070997
snps: rs2070997
snp_id_current: 2070997
context: intron
pvalue_mlog: 5.096910013008055
platform: Affymetrix [5,476,100] (imputed)
cnv: N
study:
Genome-wide association study of d-amphetamine response in healthy volunteers identifies putative associations, including cadherin 13 (CDH13).

initial_samplesize:
1 American Indian ancestry individual, 18 African American individuals, 10 Asian ancestry individuals, 325 European ancestry individuals, 17 Hispanic individuals, 6 other ancestry individuals, 4 individuals


dbdate: 2012-11-02
author: Reiner AP
date: 2012-08-28
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22939635
trait: C-reactive protein
initial_samplesize: 8,280 African American females, 3,548 Hispanic females
replication_samplesize: 3,787 African American females, 3,548 Hispanic females, 5,656 European ancestry individuals
region: 6p21.1
chrom: 6
reported_genes: TREM2
mapped_gene: TREM2
snp_gene_ids: 54209
strongest_risk_snp: rs7748513
strongest_risk_allele: G
snps: rs7748513
snp_id_current: 7748513
context: intron
pvalue_mlog: 10
platform: Affymetrix [up to 2,203,609] (imputed)
cnv: N
study:
Genome-wide association and population genetic analysis of C-reactive protein in African American and Hispanic American women.


dbdate: 2012-10-24
author: Vithana EN
date: 2012-08-26
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22922875
trait: Glaucoma (primary open-angle)
region: 11p15.1
chrom: 11
reported_genes: PLEKHA7
mapped_gene: PLEKHA7
snp_gene_ids: 144100
strongest_risk_snp: rs11024102
strongest_risk_allele: G
snps: rs11024102
snp_id_current: 11024102
context: intron
pvalue_mlog: 11.30102999566398
ci_95: [NR]
platform: Illumina [493,501]
cnv: N
study:
Genome-wide association analyses identify three new susceptibility loci for primary angle closure glaucoma.

initial_samplesize:
1,281 East Asian ancestry cases, 1,987 East Asian ancestry controls, 3,065 Singaporean Malay ancestry controls, 573 Singaporean Asian Indian ancestry cases, 2,538 Singaporean Asian Indian ancestry controls, 2,018 Vietnamese ancestry controls

replication_samplesize:
1,545 East Asian ancestry cases, 3,756 East Asian ancestry controls, 165 Saudi Arabian ancestry cases, 175 Saudi Arabian ancestry controls, 127 European ancestry cases, 4,703 European ancestry controls, 80 Indian ancestry cases, 309 Indian ancestry controls


dbdate: 2012-11-19
author: Lee HJ
date: 2012-08-25
journal: J Affect Disord
link: http://www.ncbi.nlm.nih.gov/pubmed/22925353
trait: Bipolar disorder
initial_samplesize: 2,191 European ancestry cases, 1,434 European ancestry controls
region: 1p31.3
chrom: 1
reported_genes: NF1A
mapped_gene: NFIA
snp_gene_ids: 4774
strongest_risk_snp: rs41350144
strongest_risk_allele: T
snps: rs41350144
snp_id_current: 41350144
context: intron
pvalue_mlog: 6.522878745280337
ci_95: [1.66-3.11]
platform: Affymetrix [703,012]
cnv: N
study:
A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder.


dbdate: 2012-10-23
author: Cheng I
date: 2012-08-24
journal: Cancer Epidemiol Biomarkers Prev
link: http://www.ncbi.nlm.nih.gov/pubmed/22923026
study: Evaluating genetic risk for prostate cancer among Japanese and Latinos.
trait: Prostate cancer
region: 5p15.33
chrom: 5
mapped_gene: CTD-2194D22.4
snp_gene_ids: 101929081
strongest_risk_snp: rs12653946
strongest_risk_allele: T
snps: rs12653946
snp_id_current: 12653946
context: intron
pvalue_mlog: 6.522878745280337
ci_95: [1.22-1.57]
platform: Illumina [528,023]
cnv: N
initial_samplesize:
1,033 Japanese ancestry cases, 1,042 Japanese ancestry controls, 1,043 Latino cases, 1,057 Latino controls

replication_samplesize:
1,583 Japanese ancestry cases, 3,386 Japanese ancestry  controls, 1,854 European ancestry cases, 3,748 European ancestry controls


dbdate: 2012-11-19
author: Rasmussen-Torvik LJ
date: 2012-08-23
journal: Clin Transl Sci
link: http://www.ncbi.nlm.nih.gov/pubmed/23067351
trait: LDL cholesterol
initial_samplesize: 1,249 African American individuals
region: 19q13.32
chrom: 19
reported_genes: APOE
mapped_gene: APOE
snp_gene_ids: 348
strongest_risk_snp: rs7412
snps: rs7412
snp_id_current: 7412
context: missense
pvalue_mlog: 8.698970004336019
ci_95: [8.4-16.3] mg/dL decrease
platform: Illumina [910,341]
cnv: N
study:
High density GWAS for LDL cholesterol in African Americans using electronic medical records reveals a strong protective variant in APOE.


dbdate: 2012-10-23
author: Boraska V
date: 2012-08-22
journal: Am J Med Genet B Neuropsychiatr Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22911880
trait: Eating disorders
initial_samplesize: Up to 2,567 European ancestry individuals
replication_samplesize: Up to 767 European ancestry cases, up to 486 European ancestry controls
region: 5q35.3
chrom: 5
reported_genes: RUFY1
mapped_gene: RUFY1;LOC101928445
snp_gene_ids: 80230;101928445
strongest_risk_snp: rs6894268
strongest_risk_allele: A
snps: rs6894268
snp_id_current: 6894268
context: intron;nearGene-5
pvalue_mlog: 5.522878745280337
ci_95: [0.84-2.04] unit increase
platform: Illumina [283,744]
cnv: N
study:
Genome-wide association analysis of eating disorder-related symptoms, behaviors, and personality traits.


dbdate: 2012-10-12
author: Hibar DP
date: 2012-08-18
journal: Brain Imaging Behav
link: http://www.ncbi.nlm.nih.gov/pubmed/22903471
trait: Lentiform nucleus volume
region: 1q24.3
chrom: 1
reported_genes: FMO3, FMO6P
mapped_gene: MIR1295B - FMO6P
upstream_gene_id: 100847009
downstream_gene_id: 388714
strongest_risk_snp: rs1795240
strongest_risk_allele: A
snps: rs1795240
snp_id_current: 1795240
context: Intergenic
pvalue_mlog: 7.30102999566398
ci_95: [NR] unit decrease
platform: Illumina [2,380,200] (imputed)
cnv: N
study:
Genome-wide association identifies genetic variants associated with lentiform nucleus volume in N&#x02009;=&#x02009;1345 young and elderly subjects.

initial_samplesize:
162 European ancestry Alzheimer's disease cases, 346 European ancestry mild cognitive impairment cases, 198 European ancestry controls, 639 European ancestry individuals from 364 families


dbdate: 2012-11-21
author: Inouye M
date: 2012-08-16
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22916037
trait: Metabolite levels
initial_samplesize: 6,608 European ancestry individuals
region: 1p32.3
chrom: 1
reported_genes: PCSK9, USP24
mapped_gene: GOT2P1 - RPSAP20
upstream_gene_id: 645538
downstream_gene_id: 127406
strongest_risk_snp: rs1998013
snps: rs1998013
snp_id_current: 1998013
context: Intergenic
pvalue_mlog: 12.30102999566398
platform: Illumina [~2 million] (imputed)
cnv: N
study:
Novel Loci for metabolic networks and multi-tissue expression studies reveal genes for atherosclerosis.


dbdate: 2012-11-22
author: Timofeeva MN
date: 2012-08-16
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22899653
trait: Lung cancer
initial_samplesize: up to 14,900 European ancestry cases, up to 29,485 European ancestry controls
replication_samplesize: 2,338 Han Chinese ancestry cases, 3,077 Han Chinese ancestry controls
region: 12p13.33
chrom: 12
reported_genes: RAD52
mapped_gene: RAD52
snp_gene_ids: 5893
strongest_risk_snp: rs10849605
snps: rs10849605
snp_id_current: 10849605
context: intron
pvalue_mlog: 6.221848749616355
ci_95: [1.04-1.11]
platform: Illumina [up to 536,008]
cnv: N
study:
Influence of common genetic variation on lung cancer risk: meta-analysis of 14 900 cases and 29 485 controls.


dbdate: 2012-10-23
author: Scharf JM
date: 2012-08-14
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/22889924
study: Genome-wide association study of Tourette's syndrome.
trait: Tourette syndrome
replication_samplesize: 211 Latin American ancestry cases, 285 Latin American ancestry controls
region: 9q32
chrom: 9
reported_genes: COL27A1, KIF12, ORM1
mapped_gene: COL27A1
snp_gene_ids: 85301
strongest_risk_snp: rs7868992
strongest_risk_allele: G
snps: rs7868992
snp_id_current: 7868992
context: intron
pvalue_mlog: 7.522878745280337
ci_95: [NR]
platform: Illumina [484,295]
cnv: N
initial_samplesize:
778 European ancestry cases, 4,414 European ancestry controls, 242 Ashkenazi Jewish cases, 354 Ashkenazi Jewish controls, 265 French Canadian founder cases, 196 French Canadian founder controls


dbdate: 2012-10-12
author: Stewart SE
date: 2012-08-14
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/22889921
study: Genome-wide association study of obsessive-compulsive disorder.
trait: Obsessive-compulsive disorder
region: 12q13.12
chrom: 12
reported_genes: FAIM2, AQP2
mapped_gene: LOC101927292;LOC102723941
snp_gene_ids: 101927292;102723941
strongest_risk_snp: rs297941
snps: rs297941
snp_id_current: 297941
context: ncRNA;nearGene-5
pvalue_mlog: 6.30102999566398
platform: Illumina [479,067]
cnv: N
initial_samplesize:
1,279 European ancestry cases, 5,139 European ancestry controls, 93 South African Afrikaner ancestry cases, 158  South African Afrikaner ancestry controls, 93 Ashkenazi Jewish cases, 260 Ashkenazi Jewish controls, 299 European ancestry trios, 101 trios


dbdate: 2012-10-09
author: Frazier-Wood AC
date: 2012-08-09
journal: Pharmacogenet Genomics
link: http://www.ncbi.nlm.nih.gov/pubmed/22890011
trait: Response to fenofibrate
initial_samplesize: 817 European ancestry individuals
region: 7q32.1
chrom: 7
reported_genes: AHCLY2
mapped_gene: AHCYL2
snp_gene_ids: 23382
strongest_risk_snp: rs11766298
strongest_risk_allele: T
snps: rs11766298
snp_id_current: 11766298
context: intron
pvalue_mlog: 8.397940008672036
ci_95: [2.96-5.86] unit increase
platform: Affymetrix [~2,543,887] (imputed)
cnv: N
study:
Genome-wide association study indicates variants associated with insulin signaling and inflammation mediate lipoprotein responses to fenofibrate.


dbdate: 2012-10-23
author: Hu L
date: 2012-08-07
journal: Clin Cancer Res
link: http://www.ncbi.nlm.nih.gov/pubmed/22872573
trait: Response to platinum-based chemotherapy in non-small-cell lung cancer
initial_samplesize: 528 Han Chinese ancestry cases
replication_samplesize: 340 Han Chinese ancestry cases, 409 European ancestry cases
region: 5p14.1
chrom: 5
reported_genes: CDH9
mapped_gene: MSNP1 - CDH9
upstream_gene_id: 4479
downstream_gene_id: 1007
strongest_risk_snp: rs969088
strongest_risk_allele: C
snps: rs969088
snp_id_current: 969088
context: Intergenic
pvalue_mlog: 5.698970004336018
ci_95: [1.24-1.66]
platform: NR [576,351]
cnv: N
study:
Genome-wide association study of prognosis in advanced non-small cell lung cancer patients receiving platinum-based chemotherapy.


dbdate: 2012-09-29
author: Irish Schizophrenia Genomics Consortium & the Wellcome Trust Case Control Consortium 2
date: 2012-08-07
journal: Biol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/22883433
trait: Schizophrenia
initial_samplesize: 1,606 European ancestry cases, 1,794 European ancestry controls
replication_samplesize: 13,195 European ancestry cases, 31,021 European ancestry controls
region: 6p22.1
chrom: 6
reported_genes: MHC, TRIM26
mapped_gene: TRIM26
snp_gene_ids: 7726
strongest_risk_snp: rs2523722
strongest_risk_allele: G
snps: rs2523722
snp_id_current: 2523722
context: intron
pvalue_mlog: 16
ci_95: [1.12-1.39]
platform: Affymetrix [6,212,339]
cnv: N
study:
Genome-wide association study implicates HLA-C*01:02 as a risk factor at the major histocompatibility complex locus in schizophrenia.


dbdate: 2012-10-13
author: Cheung CL
date: 2012-08-05
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22863731
trait: Thyrotoxic hypokalemic periodic paralysis
initial_samplesize: 69 Chinese ancestry cases, 1,170 East Asian ancestry controls,
replication_samplesize: 54 Chinese ancestry cases, 400 Taiwanese ancestry controls
region: 17q24.3
chrom: 17
reported_genes: KCNJ16, KCNJ2
mapped_gene: CALM2P1 - CASC17
upstream_gene_id: 100128390
downstream_gene_id: 101928165
strongest_risk_snp: rs312691
strongest_risk_allele: C
snps: rs312691
snp_id_current: 312691
context: Intergenic
pvalue_mlog: 13.09691001300805
ci_95: [2.40-4.40]
platform: Illumina [486,782]
cnv: N
study:
Genome-wide association study identifies a susceptibility locus for thyrotoxic periodic paralysis at 17q24.3.


dbdate: 2012-10-09
author: Ludwig KU
date: 2012-08-05
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22863734
trait: Orofacial clefts
initial_samplesize: Up to 666 European ancestry trios, 399 European ancestry cases, 1,318 European ancestry controls
replication_samplesize: up to 795 East Asian ancestry trios
region: 1p22.1
chrom: 1
mapped_gene: ABCA4
snp_gene_ids: 24
strongest_risk_snp: rs560426
strongest_risk_allele: G
snps: rs560426
snp_id_current: 560426
context: intron
pvalue_mlog: 11.52287874528034
ci_95: [1.243-1.623]
platform: NR [497,084]
cnv: N
study:
Genome-wide meta-analyses of nonsyndromic cleft lip with or without cleft palate identify six new risk loci.


dbdate: 2012-10-13
author: Yang C
date: 2012-08-03
journal: Immunogenetics
link: http://www.ncbi.nlm.nih.gov/pubmed/22864923
trait: IgA levels
initial_samplesize: 1,999 Han Chinese ancestry males
replication_samplesize: 1,496 East Asian ancestry males
region: 17p13.1
chrom: 17
reported_genes: TNFSF13
mapped_gene: TNFSF13;TNFSF12-TNFSF13
snp_gene_ids: 8741;407977
strongest_risk_snp: rs3803800
snps: rs3803800
snp_id_current: 3803800
context: missense;missense
pvalue_mlog: 6.522878745280337
platform: Illumina [1,940,243] (imputed)
cnv: N
study:
Genome-wide association study identifies TNFSF13 as a susceptibility gene for IgA in a South Chinese population in smokers.


dbdate: 2012-09-26
author: Patin E
date: 2012-07-26
journal: Gastroenterology
link: http://www.ncbi.nlm.nih.gov/pubmed/22841784
trait: Hepatitis C induced liver fibrosis
initial_samplesize: 1,161 European ancestry HCV-infected individuals
replication_samplesize: 1,181 European ancestry HCV-infected individuals
region: 3q23
chrom: 3
reported_genes: RNF7
mapped_gene: RNF7
snp_gene_ids: 9616
strongest_risk_snp: rs16851720
strongest_risk_allele: C
snps: rs16851720
snp_id_current: 16851720
context: intron
pvalue_mlog: 8.045757490560675
platform: Illumina [780,650] (imputed)
cnv: N
study:
Genome-wide association study identifies variants associated with progression of liver fibrosis from HCV infection.


dbdate: 2012-09-21
author: Qi Q
date: 2012-07-26
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22843503
trait: Resistin levels
initial_samplesize: 3,248 European ancestry individuals
replication_samplesize: 659 European ancestry individuals
region: 1p32.2
chrom: 1
reported_genes: C1orf168
mapped_gene: C1orf168
snp_gene_ids: 199920
strongest_risk_snp: rs17372114
strongest_risk_allele: T
snps: rs17372114
snp_id_current: 17372114
context: intron
pvalue_mlog: 6.30102999566398
ci_95: [0.020-0.060] unit increase
platform: Affymetrix & Illumina [2,543,887] (imputed)
cnv: N
study:
Genome-wide association analysis identifies TYW3/CRYZ and NDST4 loci associated with circulating resistin levels.


dbdate: 2012-09-26
author: Wilk JB
date: 2012-07-26
journal: Am J Respir Crit Care Med
link: http://www.ncbi.nlm.nih.gov/pubmed/22837378
trait: Airflow obstruction
initial_samplesize: up to 3,368 European ancestry cases, up to 29,507 European ancestry controls
replication_samplesize: 331 European ancestry cases, 2,550 European ancestry controls
region: 3p26.1
chrom: 3
reported_genes: ITPR1
mapped_gene: ITPR1
snp_gene_ids: 3708
strongest_risk_snp: rs2322734
snps: rs2322734
snp_id_current: 2322734
context: intron
pvalue_mlog: 5.096910013008055
ci_95: [NR]
platform: Affymetrix & Illumina [up to ~2,500,000] (imputed)
cnv: N
study:
Genome-wide association studies identify CHRNA5/3 and HTR4 in the development of airflow obstruction.


dbdate: 2012-09-20
author: Verweij KJ
date: 2012-07-24
journal: Addict Biol
link: http://www.ncbi.nlm.nih.gov/pubmed/22823124
trait: Cannabis use (initiation)
initial_samplesize: 10,091 individuals from 4,622 families
region: 13q14.2
chrom: 13
reported_genes: GNG5P5
mapped_gene: GNG5P5 - NAP1L4P3
upstream_gene_id: 100101935
downstream_gene_id: 730174
strongest_risk_snp: rs1417205
strongest_risk_allele: A
snps: rs1417205
snp_id_current: 1417205
context: Intergenic
pvalue_mlog: 6.096910013008056
ci_95: unit decrease
platform: Illumina [~2.4 million] (imputed)
cnv: N
study:
The genetic aetiology of cannabis use initiation: a meta-analysis of genome-wide association studies and a SNP-based heritability estimation.


dbdate: 2012-09-26
author: Ellinghaus D
date: 2012-07-23
journal: Hepatology
link: http://www.ncbi.nlm.nih.gov/pubmed/22821403
trait: Sclerosing cholangitis and ulcerative colitis (combined)
region: 2q37.3
chrom: 2
reported_genes: GPR35
mapped_gene: GPR35
snp_gene_ids: 2859
strongest_risk_snp: rs4676410
strongest_risk_allele: A
snps: rs4676410
snp_id_current: 4676410
context: intron
pvalue_mlog: 8.698970004336019
ci_95: [1.24-1.53]
platform: Affymetrix [up to 1,279,891] (imputed)
cnv: N
study:
Genome-wide association analysis in primary sclerosing cholangitis and ulcerative colitis identifies risk loci at GPR35 and TCF4.

initial_samplesize:
Up to 389 European ancestry primary sclerosing cholangitis cases, 987 European ancestry ulcerative colitis cases, 2,968 European ancestry controls

replication_samplesize:
1,012 European ancestry primary sclerosing cholangitis cases, 4,444 European ancestry ulcerative colitis cases, 11,659 European ancestry controls


dbdate: 2012-09-18
author: Hoehn R
date: 2012-07-20
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22814818
trait: Central corneal thickness
initial_samplesize: 3,931 European ancestry individuals
replication_samplesize: 1,418 European ancestry individuals
region: 16q24.2
chrom: 16
reported_genes: ZNF469
mapped_gene: BANP - ZNF469
upstream_gene_id: 54971
downstream_gene_id: 84627
strongest_risk_snp: rs9938149
strongest_risk_allele: A
snps: rs9938149
snp_id_current: 9938149
context: Intergenic
pvalue_mlog: 12
ci_95: [0.12-0.20] SD increase
platform: Affymetrix [NR] (imputed)
cnv: N
study:
Population-based meta-analysis in Caucasians confirms association with COL5A1 and ZNF469 but not COL8A2 with central corneal thickness.


dbdate: 2012-09-25
author: Coviello AD
date: 2012-07-19
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22829776
trait: Sex hormone-binding globulin levels
initial_samplesize: 21,791 European ancestry individuals
replication_samplesize: 8,175 European ancestry individuals
region: 1p13.3
chrom: 1
reported_genes: PRMT6
mapped_gene: NDE1P1 - PRMT6
upstream_gene_id: 100422372
downstream_gene_id: 55170
strongest_risk_snp: rs17496332
strongest_risk_allele: A
snps: rs17496332
snp_id_current: 17496332
context: Intergenic
pvalue_mlog: 11
ci_95: [0.020-0.036] nmol/L decrease
platform: Affmyetrix & Illumina [2,543,887] (imputed)
cnv: N
study:
A genome-wide association meta-analysis of circulating sex hormone-binding globulin reveals multiple Loci implicated in sex steroid hormone regulation.


dbdate: 2012-11-22
author: Gregersen PK
date: 2012-07-16
journal: Ann Neurol
link: http://www.ncbi.nlm.nih.gov/pubmed/23055271
trait: Myasthenia gravis
initial_samplesize: 400 European ancestry cases, 5,505 European ancestry controls
replication_samplesize: 249 European ancestry cases, 3,415 European ancestry controls
region: 1p13.2
chrom: 1
reported_genes: PTPN22
mapped_gene: PTPN22;LOC101928822
snp_gene_ids: 26191;101928822
strongest_risk_snp: rs2476601
strongest_risk_allele: A
snps: rs2476601
snp_id_current: 2476601
context: missense;intron
pvalue_mlog: 9.096910013008054
ci_95: [1.44-2.02]
platform: Illumina [274,256]
cnv: N
study:
Risk for myasthenia gravis maps to a (151) Pro&#x02192;Ala change in TNIP1 and to human leukocyte antigen-B*08.


dbdate: 2012-09-18
author: Okada Y
date: 2012-07-15
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22797727
trait: Renal function-related traits (BUN)
initial_samplesize: 39,717 East Asian ancestry individuals
replication_samplesize: 17,461 East Asian ancestry individuals
region: 1q22
chrom: 1
reported_genes: MTX1, GBA
mapped_gene: GBAP1
snp_gene_ids: 2630
strongest_risk_snp: rs2049805
strongest_risk_allele: T
snps: rs2049805
snp_id_current: 2049805
context: intron
pvalue_mlog: 11.69897000433602
ci_95: [0.0052-0.0092] mg/dl increase
platform: Affymetrix & Illumina [2,281,523] (imputed)
cnv: N
study:
Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations.


dbdate: 2012-09-20
author: Shiraishi K
date: 2012-07-15
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22797724
trait: Lung adenocarcinoma
initial_samplesize: 1,695 Japanese ancestry cases, 5,333 Japanese ancestry controls
replication_samplesize: 4,334 Japanese ancestry cases, 8,202 Japanese ancestry controls
region: 5p15.33
chrom: 5
reported_genes: TERT
mapped_gene: TERT
snp_gene_ids: 7015
strongest_risk_snp: rs2853677
strongest_risk_allele: C
snps: rs2853677
snp_id_current: 2853677
context: intron
pvalue_mlog: 39.52287874528034
ci_95: [1.32-1.50]
platform: Illumina [538,166]
cnv: N
study:
A genome-wide association study identifies two new susceptibility loci for lung adenocarcinoma in the Japanese population.


dbdate: 2012-09-12
author: Chen G
date: 2012-07-12
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22791750
trait: Insulin-related traits
initial_samplesize: 927 African American non-diabetic individuals
replication_samplesize: 570 West African ancestry non-diabetic individuals
region: 4q21.3
chrom: 4
reported_genes: SLC10A6
mapped_gene: SLC10A6
snp_gene_ids: 345274
strongest_risk_snp: rs10050311
strongest_risk_allele: T
snps: rs10050311
snp_id_current: 10050311
context: intron
pvalue_mlog: 5.096910013008055
ci_95: [0.13-0.37] unit decrease
platform: Affymetrix [5,396,838] (imputed)
cnv: N
study:
Genome-wide association study identifies novel loci association with fasting insulin and insulin resistance in African Americans.


dbdate: 2012-09-20
author: Li S
date: 2012-07-12
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22807686
trait: Hepatocellular carcinoma
initial_samplesize: 1,538 Han Chinese ancestry HBV-positive HCC cases, 1,465 Han Chinese ancestry chronic HBV carriers
replication_samplesize: 4,431 Han Chinese ancestry HBV-positive HCC cases, 4,725 Han Chinese ancestry chronic HBV carriers
region: 6p21.32
chrom: 6
reported_genes: HLA-DQA1, HLA-DRB1
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs9272105
strongest_risk_allele: A
snps: rs9272105
snp_id_current: 9272105
pvalue_mlog: 21.30102999566398
ci_95: [1.22-1.35]
platform: NR [523,663]
cnv: N
study:
GWAS identifies novel susceptibility loci on 6p21.32 and 21q21.3 for hepatocellular carcinoma in chronic hepatitis B virus carriers.


dbdate: 2012-07-19
author: Liao M
date: 2012-07-07
journal: Genes Immun
link: http://www.ncbi.nlm.nih.gov/pubmed/22673310
trait: IgG levels
initial_samplesize: 1,999 Chinese ancestry males
replication_samplesize: 1,496 Chinese ancestry males
region: 17p11.2
chrom: 17
reported_genes: TNFRSF13B
mapped_gene: TNFRSF13B
snp_gene_ids: 23495
strongest_risk_snp: rs4792800
strongest_risk_allele: G
snps: rs4792800
snp_id_current: 4792800
context: intron
pvalue_mlog: 12
platform: Illumina [1,940,243] (imputed)
cnv: N
study:
Genome-wide association study identifies common variants at TNFRSF13B associated with IgG level in a healthy Chinese male population.


dbdate: 2012-09-12
author: Himes BE
date: 2012-07-05
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22792082
trait: Asthma (bronchodilator response)
initial_samplesize: 1,644 European ancestry asthmatic cases
replication_samplesize: 1,051 European ancestry asthmatic cases
region: 2q33.1
chrom: 2
reported_genes: SPATS2L
mapped_gene: C2orf47 - SPATS2L
upstream_gene_id: 79568
downstream_gene_id: 26010
strongest_risk_snp: rs295137
strongest_risk_allele: T
snps: rs295137
snp_id_current: 295137
context: Intergenic
pvalue_mlog: 5.999999999999999
platform: Affymetrix & Illumina [4,571,615] (imputed)
cnv: N
study:
Genome-wide association analysis in asthma subjects identifies SPATS2L as a novel bronchodilator response gene.


dbdate: 2012-09-11
author: Medina-Gomez C
date: 2012-07-05
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22792070
trait: Bone mineral density
initial_samplesize: 1,834 European ancestry children, 825 children
replication_samplesize: 11,052 European ancestry individuals
region: 7q31.31
chrom: 7
reported_genes: WNT16
mapped_gene: FAM3C
snp_gene_ids: 10447
strongest_risk_snp: rs917727
strongest_risk_allele: T
snps: rs917727
snp_id_current: 917727
context: intron
pvalue_mlog: 27
ci_95: [NR] unit increase
platform: Illumina [3,021,329] (imputed)
cnv: N
study:
Meta-analysis of genome-wide scans for total body BMD in children and adults reveals allelic heterogeneity and age-specific effects at the WNT16 locus.


dbdate: 2012-09-12
author: Zheng HF
date: 2012-07-05
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22792071
trait: Bone mineral density
initial_samplesize: 5672 European ancestry individuals
region: 7q31.31
chrom: 7
reported_genes: WNT16
mapped_gene: WNT16
snp_gene_ids: 51384
strongest_risk_snp: rs2908004
strongest_risk_allele: G
snps: rs2908004
snp_id_current: 2908004
context: missense
pvalue_mlog: 15
ci_95: [NR] mg/cm3 decrease
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
WNT16 influences bone mineral density, cortical bone thickness, bone strength, and osteoporotic fracture risk.


dbdate: 2012-09-21
author: Adkins DE
date: 2012-07-03
journal: Transl Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/22760553
study: Genome-wide pharmacogenomic study of citalopram-induced side effects in STAR*D.
trait: Response to citalopram treatment
region: 7q22.1
chrom: 7
reported_genes: EMID2
mapped_gene: COL26A1
snp_gene_ids: 136227
strongest_risk_snp: rs17135437
strongest_risk_allele: A
snps: rs17135437
snp_id_current: 17135437
context: intron
pvalue_mlog: 7.522878745280337
platform: Affymetrix [421,789]
cnv: N
initial_samplesize:
1,392 European ancestry depression cases, 264 African American depression cases, 106 depression cases


dbdate: 2012-09-12
author: Loughlin
date: 2012-07-02
journal: Lancet
link: http://www.ncbi.nlm.nih.gov/pubmed/22763110
trait: Osteoarthritis
initial_samplesize: 7,410 European ancestry cases, 11,009 European ancestry controls
replication_samplesize: 7,473 European ancestry cases, 42,938 European ancestry controls
region: 1q41
chrom: 1
mapped_gene: RIMKLBP2 - ZC3H11B
upstream_gene_id: 100422371
downstream_gene_id: 643136
strongest_risk_snp: rs1417066
strongest_risk_allele: G
snps: rs1417066
snp_id_current: 1417066
context: Intergenic
pvalue_mlog: 5.999999999999999
ci_95: [1.04-1.10]
platform: Illumina [485,491]
cnv: N
study:
Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study.


dbdate: 2012-09-08
author: Byrne EM
date: 2012-07-01
journal: Sleep
link: http://www.ncbi.nlm.nih.gov/pubmed/22754043
trait: Insomnia (caffeine-induced)
initial_samplesize: 2,402 European ancestry individuals from 1,470 families
region: 14q32.12
chrom: 14
reported_genes: PRIMA1
mapped_gene: PRIMA1
snp_gene_ids: 145270
strongest_risk_snp: rs6575353
snps: rs6575353
snp_id_current: 6575353
context: intron
pvalue_mlog: 5.999999999999999
ci_95: [1.12-1.89]
platform: Illumina [2,380,486] (imputed)
cnv: N
study:
A genome-wide association study of caffeine-related sleep disturbance: confirmation of a role for a common variant in the adenosine receptor.


dbdate: 2012-09-20
author: Lu X
date: 2012-07-01
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22751097
trait: Coronary heart disease
initial_samplesize: 1,515 Han Chinese ancestry cases, 5,019 Han Chinese ancestry controls
replication_samplesize: 15,460 Han Chinese ancestry cases, 11,472 Han Chinese ancestry controls
region: 2p24.1
chrom: 2
reported_genes: TTC32, WDR35
mapped_gene: OSR1 - CISD1P1
upstream_gene_id: 130497
downstream_gene_id: 130500
strongest_risk_snp: rs2123536
strongest_risk_allele: T
snps: rs2123536
snp_id_current: 2123536
context: Intergenic
pvalue_mlog: 10.15490195998574
ci_95: [1.08-1.16]
platform: Affymetrix [~2.2 million] (imputed)
cnv: N
study:
Genome-wide association study in Han Chinese identifies four new susceptibility loci for coronary artery disease.


dbdate: 2012-08-10
author: Hai R
date: 2012-06-29
journal: Sci China Life Sci
link: http://www.ncbi.nlm.nih.gov/pubmed/22744181
trait: Lean body mass and age at menarche (combined)
initial_samplesize: 801 Han Chinese ancestry females
replication_samplesize: 1,692 European ancestry females
region: 1q23.2
chrom: 1
reported_genes: DARC
mapped_gene: ACKR1;CADM3-AS1
snp_gene_ids: 2532;100131825
strongest_risk_snp: rs3027009
snps: rs3027009
snp_id_current: 3027009
context: UTR-5;nearGene-5
pvalue_mlog: 6.154901959985743
platform: Affymetrix [909,622]
cnv: N
study:
Bivariate genome-wide association study suggests that the DARC gene influences lean body mass and age at menarche.


dbdate: 2012-08-10
author: Nishida N
date: 2012-06-21
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/22737229
trait: Hepatitis B (viral clearance)
region: 6p21.32
chrom: 6
reported_genes: HLA-DPA1
mapped_gene: HLA-DPA1
snp_gene_ids: 3113
strongest_risk_snp: rs3077
strongest_risk_allele: C
snps: rs3077
snp_id_current: 3077
context: UTR-3
pvalue_mlog: 44.39794000867204
ci_95: [1.67-1.96]
platform: Affymetrix [597,789]
cnv: N
study:
Genome-wide association study confirming association of HLA-DP with protection against chronic hepatitis B and viral clearance in Japanese and Korean.

initial_samplesize:
181 East Asian ancestry HBV carriers, 184 East Asian ancestry controls, 185 East Asian ancestry spontaneously HBV-resolved individuals

replication_samplesize:
Up to 8,045 East Asian ancestry HBV carriers, up to 9,003 East Asian ancestry controls, and up to 3,995 East Asian ancestry spontaneously HBV-resolved individuals


dbdate: 2012-08-08
author: Hager J
date: 2012-06-20
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/22745674
trait: Coronary heart disease
initial_samplesize: 1,949 Middle Eastern ancestry individuals
replication_samplesize: 2,547 Middle Eastern ancestry individuals
region: 6p24.1
chrom: 6
reported_genes: PHACTR1
mapped_gene: PHACTR1
snp_gene_ids: 221692
strongest_risk_snp: rs9349379
strongest_risk_allele: G
snps: rs9349379
snp_id_current: 9349379
context: intron
pvalue_mlog: 9.096910013008054
ci_95: [1.22-1.47]
platform: Illumina [513,079]
cnv: N
study:
Genome-wide association study in a Lebanese cohort confirms PHACTR1 as a major determinant of coronary artery stenosis.


dbdate: 2012-08-30
author: Sobrin L
date: 2012-06-15
journal: Ophthalmology
link: http://www.ncbi.nlm.nih.gov/pubmed/22705344
trait: Age-related macular degeneration (CNV vs. GA)
region: 10q26.13
chrom: 10
reported_genes: ARMS2,HTRA1
mapped_gene: ARMS2
snp_gene_ids: 387715
strongest_risk_snp: rs10490924
strongest_risk_allele: T
snps: rs10490924
snp_id_current: 10490924
context: missense
pvalue_mlog: 13.15490195998574
ci_95: [NR]
platform: Affymetrix & Illumina [6,036,699] (imputed)
cnv: N
study:
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.

initial_samplesize:
1,775 European ancestry choroidal neovascularization cases, 819 European ancestry geographic atrophy cases,

replication_samplesize:
4,515 European and unknown ancestry choroidal neovascularization cases, 868 European and unknown ancestry geographic atrophy cases


dbdate: 2012-08-15
author: Sobrin L
date: 2012-06-15
journal: Ophthalmology
link: http://www.ncbi.nlm.nih.gov/pubmed/22705344
trait: Age-related macular degeneration (CNV)
initial_samplesize: 1,775 European ancestry choroidal neovascularization cases, 4,134 European ancestry controls
region: 1q31.3
chrom: 1
reported_genes: CFH
mapped_gene: CFH
snp_gene_ids: 3075
strongest_risk_snp: rs1061170
snps: rs1061170
snp_id_current: 1061170
context: missense
pvalue_mlog: 108
ci_95: [2.5-3.03]
platform: Affymetrix & Illumina [6,036,699] (imputed)
cnv: N
study:
Heritability and genome-wide association study to assess genetic differences between advanced age-related macular degeneration subtypes.

replication_samplesize:
4,515 European and unknown ancestry choroidal neovascularization cases, 15,240 European and unknown ancestry controls


dbdate: 2012-08-10
author: Kawaguchi T
date: 2012-06-14
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/22719876
trait: Nonalcoholic fatty liver disease
initial_samplesize: 529 Japanese ancestry cases, 932 Japanese ancestry controls
region: 22q13.31
chrom: 22
reported_genes: PNPLA3
mapped_gene: PNPLA3
snp_gene_ids: 80339
strongest_risk_snp: rs738409
strongest_risk_allele: G
snps: rs738409
snp_id_current: 738409
context: missense
pvalue_mlog: 10
ci_95: [1.43-1.94]
platform: Illumina [484,751]
cnv: N
study:
Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese.


dbdate: 2012-08-15
author: Tang W
date: 2012-06-14
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22703881
trait: Activated partial thromboplastin time
initial_samplesize: 9,240 European ancestry individuals
replication_samplesize: 2611 European ancestry individuals
region: 1q24.2
chrom: 1
reported_genes: F5, SELP
mapped_gene: F5
snp_gene_ids: 2153
strongest_risk_snp: rs6028
strongest_risk_allele: C
snps: rs6028
snp_id_current: 6028
context: cds-synon
pvalue_mlog: 8.522878745280337
ci_95: [0.14-0.31] unit increase
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.


dbdate: 2012-08-08
author: Cipriani V
date: 2012-06-13
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22694956
trait: Age-related macular degeneration
initial_samplesize: 893 European ancestry cases, 2,199 European ancestry controls
replication_samplesize: 1,411 European ancestry cases, 1,431 European ancestry controls
region: 6p21.33
chrom: 6
reported_genes: TNXB
mapped_gene: TNXB
snp_gene_ids: 7148
strongest_risk_snp: rs12153855
strongest_risk_allele: C
snps: rs12153855
snp_id_current: 12153855
context: intron
pvalue_mlog: 8.999999999999998
ci_95: [1.28-1.63]
platform: Illumina [2,272,849] (imputed)
cnv: N
study:
Genome-wide association study of age-related macular degeneration identifies associated variants in the TNXB-FKBPL-NOTCH4 region of chromosome 6p21.3.


dbdate: 2012-08-07
author: Hotaling JM
date: 2012-06-13
journal: J Urol
link: http://www.ncbi.nlm.nih.gov/pubmed/22704111
trait: Erectile dysfunction
region: 3q13.11
chrom: 3
reported_genes: ALCAM
mapped_gene: TRNAE27P - ALCAM
upstream_gene_id: 100189440
downstream_gene_id: 214
strongest_risk_snp: rs9810233
strongest_risk_allele: G
snps: rs9810233
snp_id_current: 9810233
context: Intergenic
pvalue_mlog: 6.154901959985743
platform: Illumina [840,354]
cnv: N
study:
Pilot genome-wide association search identifies potential loci for risk of erectile dysfunction in type 1 diabetes using the DCCT/EDIC study cohort.

initial_samplesize:
125 European ancestry Erectile dysfunction cases with Type 1 Diabetes, 403 European ancestry non Erectile dysfunction controls with Type 1 Diabetes


dbdate: 2012-08-14
author: Bergen SE
date: 2012-06-12
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/22688191
trait: Bipolar disorder
initial_samplesize: 836 European ancestry cases, 2,093 European ancestry controls
region: 4q34.3
chrom: 4
reported_genes: Intergenic
mapped_gene: RNA5SP173 - LINC00290
upstream_gene_id: 100873437
downstream_gene_id: 728081
strongest_risk_snp: rs17746001
strongest_risk_allele: T
snps: rs17746001
snp_id_current: 17746001
context: Intergenic
pvalue_mlog: 6.522878745280337
ci_95: [NR]
platform: Affymetrix [745,006]
cnv: N
study:
Genome-wide association study in a Swedish population yields support for greater CNV and MHC involvement in schizophrenia compared with bipolar disorder.


dbdate: 2012-08-14
author: Bergen SE
date: 2012-06-12
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/22688191
trait: Bipolar disorder and schizophrenia
region: 4q34.3
chrom: 4
reported_genes: Intergenic
mapped_gene: RNA5SP173 - LINC00290
upstream_gene_id: 100873437
downstream_gene_id: 728081
strongest_risk_snp: rs17746001
strongest_risk_allele: T
snps: rs17746001
snp_id_current: 17746001
context: Intergenic
pvalue_mlog: 6.522878745280337
ci_95: [NR]
platform: Affymetrix [745,006]
cnv: N
initial_samplesize:
2,111 European ancestry schizophrenia cases, 836 European ancestry bipolar disorder cases, 2,535 European ancestry controls


dbdate: 2012-08-07
author: Sinner MF
date: 2012-06-06
journal: Heart Rhythm
link: http://www.ncbi.nlm.nih.gov/pubmed/22683750
trait: Cardiac repolarization
initial_samplesize: 7,482 European ancestry individuals
replication_samplesize: 7,151 European ancestry individuals
region: 17q25.2
chrom: 17
reported_genes: MGAT5B, SEC14L
mapped_gene: MGAT5B - SNHG20
upstream_gene_id: 146664
downstream_gene_id: 654434
strongest_risk_snp: rs11653989
strongest_risk_allele: T
snps: rs11653989
snp_id_current: 11653989
context: Intergenic
pvalue_mlog: 5.522878745280337
ci_95: [1.32-2.0]
platform: Affymetrix & Illumina [2,523,555] (imputed)
cnv: N
study:
A meta-analysis of genome-wide association studies of the electrocardiographic early repolarization pattern.


dbdate: 2012-07-19
author: Han JY
date: 2012-06-05
journal: Pharmacogenomics J
link: http://www.ncbi.nlm.nih.gov/pubmed/22664479
trait: Response to irinotecan in non-small-cell lung cancer
initial_samplesize: 101 non-small-cell lung cancer cases
replication_samplesize: 146 non-small-cell lung cancer cases
region: 8q13.2
chrom: 8
reported_genes: C8orf34
mapped_gene: C8orf34
snp_gene_ids: 116328
strongest_risk_snp: rs1517114
strongest_risk_allele: C
snps: rs1517114
snp_id_current: 1517114
context: intron
pvalue_mlog: 5.045757490560675
ci_95: [2.10-8.00]
platform: Affyemtrix [312,230]
cnv: N
study:
A genome-wide association study for irinotecan-related severe toxicities in patients with advanced non-small-cell lung cancer.


dbdate: 2012-08-15
author: Heit JA
date: 2012-06-05
journal: J Thromb Haemost
link: http://www.ncbi.nlm.nih.gov/pubmed/22672568
trait: Venous thromboembolism
initial_samplesize: 1,503 European and other ancestry cases, 1,459 European and other ancestry controls
replication_samplesize: 1,407 Other ancestry cases, 1,418 Other ancestry controls
region: 1q24.2
chrom: 1
reported_genes: F5
mapped_gene: F5
snp_gene_ids: 2153
strongest_risk_snp: rs6025
strongest_risk_allele: T
snps: rs6025
snp_id_current: 6025
context: missense
pvalue_mlog: 21.69897000433602
ci_95: [2.76-4.60]
platform: Illumina [~2.5 million] (imputed)
cnv: N
study:
A genome-wide association study of venous thromboembolism identifies risk variants in chromosomes 1q24.2 and 9q.


dbdate: 2012-07-27
author: Prescott J
date: 2012-06-04
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/22675492
trait: Estradiol levels
initial_samplesize: 1,583 European ancestry females
region: 20q12
chrom: 20
reported_genes: Intergenic
mapped_gene: ATG3P1 - HSPE1P1
upstream_gene_id: 100135756
downstream_gene_id: 140895
strongest_risk_snp: rs6016142
strongest_risk_allele: T
snps: rs6016142
snp_id_current: 6016142
context: Intergenic
pvalue_mlog: 7.221848749616355
ci_95: [NR] unit decrease
platform: Illumina [~2.5 million] (imputed)
cnv: N
study:
Genome-wide association study of circulating estradiol, testosterone, and sex hormone-binding globulin in postmenopausal women.


dbdate: 2012-08-15
author: Li R
date: 2012-05-31
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22693459
trait: Male-pattern baldness
initial_samplesize: 3,891 European ancestry cases, 8,915 European ancestry controls
region: 1p36.22
chrom: 1
reported_genes: TARDBP
mapped_gene: C1orf127
snp_gene_ids: 148345
strongest_risk_snp: rs12565727
strongest_risk_allele: A
snps: rs12565727
snp_id_current: 12565727
context: intron
pvalue_mlog: 10.04575749056067
ci_95: [1.22-1.45]
platform: Affymetrix & Illumina [2,391,230] (imputed)
cnv: N
study:
Six novel susceptibility Loci for early-onset androgenetic alopecia and their unexpected association with common diseases.


dbdate: 2012-08-07
author: Perry JR
date: 2012-05-31
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22693455
trait: Type 2 diabetes
initial_samplesize: 2,112 lean type 2 diabetes cases, 4,123 obese type 2 diabetes cases, 54,412 controls
replication_samplesize: 2,881 lean type 2 diabetes cases, 8,702 obese type 2 diabetes cases, 18,957 controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DQA2
strongest_risk_snp: rs3916765
strongest_risk_allele: A
snps: rs3916765
snp_id_current: 3916765
context: Intergenic
pvalue_mlog: 5.999999999999999
ci_95: [1.12-1.31]
cnv: N
study:
Stratifying type 2 diabetes cases by BMI identifies genetic risk variants in LAMA1 and enrichment for risk variants in lean compared to obese cases.


dbdate: 2012-07-19
author: Wang KS
date: 2012-05-31
journal: J Mol Neurosci
link: http://www.ncbi.nlm.nih.gov/pubmed/22648509
trait: Formal thought disorder in schizophrenia
initial_samplesize: 835 European ancestry cases, 2,694 European ancestry controls
region: 11q24.2
chrom: 11
reported_genes: PKNOX2
mapped_gene: PKNOX2 - FEZ1
upstream_gene_id: 63876
downstream_gene_id: 9638
strongest_risk_snp: rs1783925
snps: rs1783925
snp_id_current: 1783925
context: Intergenic
pvalue_mlog: 6.397940008672037
ci_95: [NR]
platform: Affymetrix [729,454]
cnv: N
study:
PKNOX2 is associated with formal thought disorder in schizophrenia: a meta-analysis of two genome-wide association studies.


dbdate: 2012-07-17
author: Pajewski NM
date: 2012-05-30
journal: Vaccine
link: http://www.ncbi.nlm.nih.gov/pubmed/22658931
trait: Immune response to anthrax vaccine
initial_samplesize: 726 European ancestry individuals
region: 1p36.22
chrom: 1
reported_genes: SPSB1
mapped_gene: SPSB1
snp_gene_ids: 80176
strongest_risk_snp: rs11121382
strongest_risk_allele: C
snps: rs11121382
snp_id_current: 11121382
context: intron
pvalue_mlog: 5.397940008672037
ci_95: [0.056-0.142] unit decrease
platform: Affymetrix [736,996]
cnv: N
study:
A genome-wide association study of host genetic determinants of the antibody response to Anthrax Vaccine Adsorbed.


dbdate: 2012-07-19
author: Shiffman D
date: 2012-05-30
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/22666496
trait: Response to statin therapy
replication_samplesize: 590 individuals with an event, 4,654 individuals without an event
region: 8q13.1
chrom: 8
reported_genes: DNAJC5B, TRIM55, CRH
mapped_gene: DNAJC5B
snp_gene_ids: 85479
strongest_risk_snp: rs13279522
snps: rs13279522
snp_id_current: 13279522
context: intron
pvalue_mlog: 6.30102999566398
ci_95: [1.33-1.92]
platform: Illumina [657,366]
cnv: N
study:
Genome-wide study of gene variants associated with differential cardiovascular event reduction by pravastatin therapy.

initial_samplesize:
667 European ancestry event individuals, 2,246 European ancestry non-event individuals, 18 African American event individuals, 60 African American non-event individuals, 20 Hispanic event individuals, 65 Hispanic non-event individuals, 6 Asian, Pacific or other ancestry event individuals, 27 Asian, Pacific or other ancestry non-event individuals


dbdate: 2012-07-17
author: Dunlop MG
date: 2012-05-27
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22634755
study: Common variation near CDKN1A, POLD3 and SHROOM2 influences colorectal cancer risk.
trait: Colorectal cancer
initial_samplesize: 8,323 European ancestry cases, 9,457 European ancestry controls
region: 6p21.2
chrom: 6
reported_genes: CDKN1A
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs1321311
snps: rs1321311
snp_id_current: 1321311
pvalue_mlog: 10
ci_95: [1.07-1.13]
platform: Illumina [NR] (imputed)
cnv: N
replication_samplesize:
19,513 European ancestry cases, 17,657 European ancestry controls, 1,583 Japanese ancestry cases, 1,898 Japanese ancestry controls


dbdate: 2012-07-17
author: Wei S
date: 2012-05-27
journal: Carcinogenesis
link: http://www.ncbi.nlm.nih.gov/pubmed/22637743
trait: Lung cancer-asbestos exposure interaction
initial_samplesize: 1,154 European ancestry cases, 1,137 European ancestry controls
region: 2q34
chrom: 2
reported_genes: PTHR2
mapped_gene: LOC101927960
snp_gene_ids: 101927960
strongest_risk_snp: rs13383928
strongest_risk_allele: C
snps: rs13383928
snp_id_current: 13383928
context: intron
pvalue_mlog: 5.698970004336018
platform: Illumina [307,944]
cnv: N
study:
Genome-wide gene-environment interaction analysis for asbestos exposure in lung cancer susceptibility.


dbdate: 2012-08-07
author: Kennedy RB
date: 2012-05-19
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22610502
trait: Immune reponse to smallpox (secreted IFN-alpha)
initial_samplesize: Up to 512 European ancestry individuals, up to 199 African American individuals
region: 2p14
chrom: 2
reported_genes: WDR92
mapped_gene: WDR92
snp_gene_ids: 116143
strongest_risk_snp: rs4078978
strongest_risk_allele: A
snps: rs4078978
snp_id_current: 4078978
context: intron
pvalue_mlog: 17.69897000433602
platform: Illumina [NR]
cnv: N
study:
Genome-wide analysis of polymorphisms associated with cytokine responses in smallpox vaccine recipients.


dbdate: 2012-07-31
author: Melville SA
date: 2012-05-15
journal: Ann Neurol
link: http://www.ncbi.nlm.nih.gov/pubmed/22745009
study: Multiple loci influencing hippocampal degeneration identified by genome scan.
trait: Hippocampal atrophy
replication_samplesize: 419 African American Alzheimer disease cases
region: 2p22.3
chrom: 2
reported_genes: TTC27
mapped_gene: TTC27
snp_gene_ids: 55622
strongest_risk_snp: rs1031261
strongest_risk_allele: C
snps: rs1031261
snp_id_current: 1031261
context: intron
pvalue_mlog: 5.698970004336018
platform: Illumina [2,131,250] (imputed)
cnv: N
initial_samplesize:
1149 European ancestry Alzheimer disease cases, 336 European ancestry individuals with mild cognitive impairment, 188 European ancestry controls


dbdate: 2012-07-11
author: Sasayama D
date: 2012-05-15
journal: Pharmacogenomics J
link: http://www.ncbi.nlm.nih.gov/pubmed/22584459
trait: Response to antidepressants
initial_samplesize: 92 Japanese ancestry cases
replication_samplesize: 136 Japanese ancestry cases
region: 7q22.1
chrom: 7
reported_genes: CUX1
mapped_gene: CUX1
snp_gene_ids: 1523
strongest_risk_snp: rs365836
strongest_risk_allele: A
snps: rs365836
snp_id_current: 365836
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [2.38-9.64]
platform: Illumina [291,512]
cnv: N
study:
Possible association of CUX1 gene polymorphisms with antidepressant response in major depressive disorder.


dbdate: 2012-08-15
author: Manning AK
date: 2012-05-13
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22581228
trait: Fasting glucose-related traits (interaction with BMI)
initial_samplesize: Up to 58,074 European ancestry individuals
replication_samplesize: Up tp 38,422 European ancestry individuals
region: 11q13.4
chrom: 11
reported_genes: ARAP1
mapped_gene: ARAP1
snp_gene_ids: 116985
strongest_risk_snp: rs11603334
snps: rs11603334
snp_id_current: 11603334
context: intron
pvalue_mlog: 13.69897000433602
platform: Affymetrix & Illumina [~2.4 million] (imputed)
cnv: N
study:
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance.


dbdate: 2012-08-17
author: Fox CS
date: 2012-05-10
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22589738
trait: Subcutaneous adipose tissue
initial_samplesize: 5,560 European ancestry females and 4,997 European ancestry males
region: 13q14.2
chrom: 13
reported_genes: HTR2A
mapped_gene: HTR2A-AS1 - GNG5P5
upstream_gene_id: 100874082
downstream_gene_id: 100101935
strongest_risk_snp: rs12583882
strongest_risk_allele: G
snps: rs12583882
snp_id_current: 12583882
context: Intergenic
pvalue_mlog: 5.221848749616356
platform: Affymetrix & Illumina [2.5 million] (imputed)
cnv: N
study:
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.


dbdate: 2012-08-17
author: Fox CS
date: 2012-05-10
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22589738
trait: Visceral adipose tissue adjusted for BMI
initial_samplesize: 5,560 European ancestry females and 4,997 European ancestry males
region: 5q31.3
chrom: 5
reported_genes: PCDHAC1
snp_gene_ids: 9752;56134;56135;56136;56137;56138;56139;56140;56141;56142;56143;56144;56145;56146;56147
strongest_risk_snp: rs31872
strongest_risk_allele: G
snps: rs31872
snp_id_current: 31872
pvalue_mlog: 5.522878745280337
platform: Affymetrix & Illumina [2.5 million] (imputed)
cnv: N
mapped_gene:
PCDHA9;PCDHAC2;PCDHAC1;PCDHA13;PCDHA12;PCDHA11;PCDHA10;PCDHA8;PCDHA7;PCDHA6;PCDHA5;PCDHA4;PCDHA3;PCDHA2;PCDHA1

context:
intron;intron;intron;intron;intron;intron;intron;intron;intron;intron;intron;intron;intron;intron;intron


dbdate: 2012-07-27
author: Castano Betancourt MC
date: 2012-05-07
journal: Proc Natl Acad Sci U S A
link: http://www.ncbi.nlm.nih.gov/pubmed/22566624
trait: Osteoarthritis
initial_samplesize: 6,523 European ancestry individuals
replication_samplesize: 4,442 European ancestry individuals
region: 19p13.3
chrom: 19
reported_genes: DOT1L
mapped_gene: DOT1L
snp_gene_ids: 84444
strongest_risk_snp: rs12982744
strongest_risk_allele: G
snps: rs12982744
snp_id_current: 12982744
context: intron
pvalue_mlog: 11
ci_95: [NR] mm increase
platform: Illumina [2,455,290] (imputed)
cnv: N
study:
Genome-wide association and functional studies identify the DOT1L gene to be involved in cartilage thickness and hip osteoarthritis.


dbdate: 2012-08-09
author: Malhotra AK
date: 2012-05-07
journal: Arch Gen Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/22566560
trait: Antipsychotic drug-induced weight gain
initial_samplesize: 77 European ancestry individuals, 32 African American individuals, 30 Other ancestry individuals
replication_samplesize: 183 European ancestry individuals, 22 African American individuals
region: 18q21.32
chrom: 18
reported_genes: MC4R
mapped_gene: RPS3AP49 - MC4R
upstream_gene_id: 400652
downstream_gene_id: 4160
strongest_risk_snp: rs489693
snps: rs489693
snp_id_current: 489693
context: Intergenic
pvalue_mlog: 11.22184874961635
platform: Illumina [803,582]
cnv: N
study:
Association between common variants near the melanocortin 4 receptor gene and severe antipsychotic drug-induced weight gain.


dbdate: 2012-07-21
author: Turner ST
date: 2012-05-07
journal: Hypertension
link: http://www.ncbi.nlm.nih.gov/pubmed/22566498
trait: Response to angiotensin II receptor blocker therapy
initial_samplesize: 198 European ancestry hypertensive individuals, 193 African American hypertensive individuals
region: 12p13.33
chrom: 12
reported_genes: IQSEC3
mapped_gene: IQSEC3
snp_gene_ids: 440073
strongest_risk_snp: rs2011738
strongest_risk_allele: G
snps: rs2011738
snp_id_current: 2011738
context: intron
pvalue_mlog: 5.221848749616356
ci_95: [0.71-1.97] unit increase
platform: Affymetrix [~2.3 million] (imputed)
cnv: N
study:
Genomic association analysis identifies multiple loci influencing antihypertensive response to an angiotensin II receptor blocker.


dbdate: 2012-07-10
author: Krintel SB
date: 2012-05-06
journal: Pharmacogenet Genomics
link: http://www.ncbi.nlm.nih.gov/pubmed/22569225
trait: Response to TNF-alpha inhibitors in rheumatoid arthritis
initial_samplesize: 196 European ancestry cases
region: 15q26.2
chrom: 15
reported_genes: NR2F2
mapped_gene: LINC00924 - NR2F2-AS1
upstream_gene_id: 145820
downstream_gene_id: 644192
strongest_risk_snp: rs10520789
snps: rs10520789
snp_id_current: 10520789
context: Intergenic
pvalue_mlog: 6.221848749616355
platform: Illumina [486,450]
cnv: N
study:
Investigation of single nucleotide polymorphisms and biological pathways associated with response to TNF&#x003b1; inhibitors in patients with rheumatoid arthritis.


dbdate: 2012-06-20
author: Kenny EE
date: 2012-05-04
journal: Science
link: http://www.ncbi.nlm.nih.gov/pubmed/22556244
study: Melanesian blond hair is caused by an amino acid change in TYRP1.
trait: Hair color
region: 9p23
chrom: 9
reported_genes: TYRP1
mapped_gene: JKAMPP1 - TYRP1
upstream_gene_id: 100049717
downstream_gene_id: 7306
strongest_risk_snp: rs13289810
snps: rs13289810
snp_id_current: 13289810
context: Intergenic
pvalue_mlog: 19
platform: Illumina [589,241]
cnv: N
initial_samplesize:
43 Solomon Islander ancestry blond haired individuals, 42 Solomon Islander ancestry dark haired individuals


dbdate: 2012-07-03
author: Kang SJ
date: 2012-05-03
journal: Genes Brain Behav
link: http://www.ncbi.nlm.nih.gov/pubmed/22554406
trait: Electroencephalographic traits in alcoholism
initial_samplesize: 1,560 European ancestry individuals from 117 families
region: 21q22.13
chrom: 21
reported_genes: KCNJ6
mapped_gene: KCNJ6
snp_gene_ids: 3763
strongest_risk_snp: rs2835872
strongest_risk_allele: G
snps: rs2835872
snp_id_current: 2835872
context: intron
pvalue_mlog: 9.301029995663981
ci_95: [NR] unit decrease
platform: Illumina [634,583]
cnv: N
study:
Family-based genome-wide association study of frontal &#x003b8; oscillations identifies potassium channel gene KCNJ6.


dbdate: 2012-06-22
author: Osman W
date: 2012-04-27
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/22558069
trait: Non-albumin protein levels
initial_samplesize: Up to 9,103 Japanese ancestry individuals
replication_samplesize: Up to 1,629 Japanese ancestry individuals
region: 17p11.2
chrom: 17
reported_genes: TNFRSF13B
mapped_gene: TNFRSF13B
snp_gene_ids: 23495
strongest_risk_snp: rs4985726
strongest_risk_allele: G
snps: rs4985726
snp_id_current: 4985726
context: intron
pvalue_mlog: 14
ci_95: [0.080-0.134] unit increase
platform: Illumina [2,178,644] (imputed)
cnv: N
study:
Association of common variants in TNFRSF13B, TNFSF13, and ANXA3 with serum levels of non-albumin protein and immunoglobulin isotypes in Japanese.


dbdate: 2012-06-18
author: Wiggs JL
date: 2012-04-26
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22570617
trait: Glaucoma (primary open-angle)
initial_samplesize: 3,146 European ancestry cases, 3,487 European ancestry controls
region: 9p21.3
chrom: 9
reported_genes: CDKN2BAS
mapped_gene: CDKN2B-AS1
snp_gene_ids: 100048912
strongest_risk_snp: rs2157719
snps: rs2157719
snp_id_current: 2157719
context: intron
pvalue_mlog: 17.69897000433602
ci_95: [1.33-1.59]
platform: Illumina [495,132] (imputed)
cnv: N
study:
Common variants at 9p21 and 8q22 are associated with increased susceptibility to optic nerve degeneration in glaucoma.


dbdate: 2012-06-18
author: Zhao H
date: 2012-04-26
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22541561
trait: Non-obstructive azoospermia
initial_samplesize: 802 Han Chinese ancestry cases, 1,863 Han Chinese ancestry controls
replication_samplesize: 1,424 Han Chinese ancestry cases, 2,713 Han Chinese ancestry controls
region: 6p21.32
chrom: 6
reported_genes: HLA-DRA
mapped_gene: HLA-DRA
snp_gene_ids: 3122
strongest_risk_snp: rs7192
strongest_risk_allele: T
snps: rs7192
snp_id_current: 7192
context: missense
pvalue_mlog: 5.522878745280337
ci_95: [NR]
platform: Illumina & Affymetrix [912,924]
cnv: N
study:
A genome-wide association study reveals that variants within the HLA region are associated with risk for nonobstructive azoospermia.


dbdate: 2012-06-18
author: Rice JP
date: 2012-04-24
journal: Addiction
link: http://www.ncbi.nlm.nih.gov/pubmed/22524403
trait: Nicotine dependence
initial_samplesize: 2,267 European ancestry individuals, 99 Hispanic individuals, 999 African American individuals
replication_samplesize: 835 individuals
region: 8p11.21
chrom: 8
reported_genes: CHRNB3
mapped_gene: SMIM19 - CHRNB3
upstream_gene_id: 114926
downstream_gene_id: 1142
strongest_risk_snp: rs1451240
snps: rs1451240
snp_id_current: 1451240
context: Intergenic
pvalue_mlog: 15.15490195998574
platform: Illumina [948,658]
cnv: N
study:
CHRNB3 is more strongly associated with Fagerstr&#x000f6;m test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies results.


dbdate: 2012-06-19
author: Rasmussen-Torvik LJ
date: 2012-04-16
journal: Genet Epidemiol
link: http://www.ncbi.nlm.nih.gov/pubmed/22508271
trait: Fasting plasma glucose
region: 11q14.3
chrom: 11
reported_genes: MTNR1B
mapped_gene: MTNR1B
snp_gene_ids: 4544
strongest_risk_snp: rs10830963
strongest_risk_allele: G
snps: rs10830963
snp_id_current: 10830963
context: intron
pvalue_mlog: 12
ci_95: [1.01-1.75] mg/dL increase
platform: Affymetrix [NR] (imputed)
cnv: N
study:
Fasting glucose GWAS candidate region analysis across ethnic groups in the Multiethnic Study of Atherosclerosis (MESA).

initial_samplesize:
2,349 European ancestry individuals, 664 Chinese ancestry individuals, 1,366 African American individuals, 1,171 Hispanic individuals


dbdate: 2012-06-18
author: Rawal R
date: 2012-04-16
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22494929
trait: Thyroid function
initial_samplesize: 3,736 European ancestry individuals
replication_samplesize: 3,727 European ancestry individuals
region: 5q13.3
chrom: 5
reported_genes: PDE8B
mapped_gene: PDE8B
snp_gene_ids: 8622
strongest_risk_snp: rs2046045
strongest_risk_allele: T
snps: rs2046045
snp_id_current: 2046045
context: intron
pvalue_mlog: 26.52287874528033
ci_95: [0.093-0.137] unit decrease
platform: Affymetrix & Illumina [2,524,918] (imputed)
cnv: N
study:
Meta-analysis of two genome-wide association studies identifies four genetic loci associated with thyroid function.


dbdate: 2013-04-11
author: Estrada K
date: 2012-04-15
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22504420
trait: Bone mineral density
initial_samplesize: Up to 32,961 European and East Asian ancestry individuals
replication_samplesize: Up to 50,933 European and East Asian ancestry individuals
region: 7q36.1
chrom: 7
reported_genes: ABCF2
mapped_gene: ABCF2
snp_gene_ids: 10061
strongest_risk_snp: rs7812088
strongest_risk_allele: A
snps: rs7812088
snp_id_current: 7812088
context: intron
pvalue_mlog: 8.154901959985743
ci_95: [NR] unit increase
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.


dbdate: 2012-06-21
author: Stein JL
date: 2012-04-15
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22504417
study: Identification of common variants associated with human hippocampal and intracranial volumes.
trait: Brain structure
initial_samplesize: 2,020 European ancestry neuropsychiatric disorder cases, 5,775 European ancestry controls
region: 12q24.22
chrom: 12
reported_genes: HRK, FBXW8
mapped_gene: HRK - RPL36P15
upstream_gene_id: 8739
downstream_gene_id: 100271334
strongest_risk_snp: rs7294919
strongest_risk_allele: C
snps: rs7294919
snp_id_current: 7294919
context: Intergenic
pvalue_mlog: 15.15490195998574
ci_95: [36.04-59.12] mm3 increase
platform: Affymetrix & Illumina [NR] (imputed)
cnv: N
replication_samplesize:
599 European ancestry neuropsychiatric disorder cases, 11,915 European ancestry controls, 143 European ancestry and African American neuropsychiatric disorder cases, 94 European ancestry and African American controls, 605 Hispanic controls


dbdate: 2012-05-25
author: Jylhava J
date: 2012-04-12
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/22511988
trait: Circulating cell-free DNA
initial_samplesize: 1,841 individuals
region: 2q37.1
chrom: 2
reported_genes: UGT1A1
mapped_gene: UGT1A10;UGT1A8;UGT1A7;UGT1A6;UGT1A5;UGT1A9;UGT1A4;UGT1A1;UGT1A3
snp_gene_ids: 54575;54576;54577;54578;54579;54600;54657;54658;54659
strongest_risk_snp: rs6742078
strongest_risk_allele: T
snps: rs6742078
snp_id_current: 6742078
context: intron;intron;intron;intron;intron;intron;intron;intron;intron
pvalue_mlog: 22.69897000433602
ci_95: [0.27-0.40] ug/ml increase
platform: Illumina [2,543,887] (imputed)
cnv: N
study:
A genome-wide association study identifies UGT1A1 as a regulator of serum cell-free DNA in young adults: The Cardiovascular Risk in Young Finns Study.


dbdate: 2012-06-19
author: Wang J
date: 2012-04-10
journal: Pharmacogenomics J
link: http://www.ncbi.nlm.nih.gov/pubmed/22491018
trait: Response to tocilizumab in rheumatoid arthritis
initial_samplesize: 1,157 European and other ancestry rheumatoid arthritis cases
replication_samplesize: 526 European and other ancestry rheumatoid arthritis cases
region: 20p13
chrom: 20
reported_genes: Intergenic
mapped_gene: EBF4 - RPL19P1
upstream_gene_id: 57593
downstream_gene_id: 140759
strongest_risk_snp: rs6138892
snps: rs6138892
snp_id_current: 6138892
context: Intergenic
pvalue_mlog: 6.522878745280337
ci_95: [NR] unit increase
platform: Illumina [534,053]
cnv: N
study:
Genome-wide association analysis implicates the involvement of eight loci with response to tocilizumab for the treatment of rheumatoid arthritis.


dbdate: 2012-07-16
author: Ellinghaus D
date: 2012-04-06
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22482804
trait: Crohn's disease and psoriasis
region: 10q22.3
chrom: 10
reported_genes: ZMIZ1
mapped_gene: ZMIZ1
snp_gene_ids: 57178
strongest_risk_snp: rs1250544
strongest_risk_allele: G
snps: rs1250544
snp_id_current: 1250544
context: intron
pvalue_mlog: 13.15490195998574
ci_95: [NR]
platform: Affymetrix, Illumina & Perlegen [1,116,213] (imputed)
cnv: N
study:
Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.

initial_samplesize:
2,529 European ancestry psoriasis cases, 2,142 European ancestry Crohn's disease cases, 10,460 European ancestry controls

replication_samplesize:
Up to 3,187 European ancestry psoriasis cases, 4,073 European ancestry Crohn's disease cases, 10,100 European ancestry controls


dbdate: 2012-05-11
author: Doumatey AP
date: 2012-04-05
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22492993
trait: C-reactive protein
initial_samplesize: 837 African American individuals
replication_samplesize: 486 West African ancestry individuals
region: 1q23.2
chrom: 1
reported_genes: CRPP1, CRP
mapped_gene: OR10J6P - CRPP1
upstream_gene_id: 401973
downstream_gene_id: 171422
strongest_risk_snp: rs726640
snps: rs726640
snp_id_current: 726640
context: Intergenic
pvalue_mlog: 12.69897000433602
ci_95: [0.32-0.56] log mg/dl increase
platform: Affymetrix [2,366,856] (imputed)
cnv: N
study:
C-reactive protein (CRP) promoter polymorphisms influence circulating CRP levels in a genome-wide association study of African Americans.


dbdate: 2012-05-15
author: Zuo L
date: 2012-04-04
journal: Am J Med Genet B Neuropsychiatr Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22488850
study: Genome-wide search for replicable risk gene regions in alcohol and nicotine co-dependence.
trait: Alcohol and nictotine co-dependence
region: 2p21
chrom: 2
reported_genes: SIX3
mapped_gene: CAMKMT - SIX3-AS1
upstream_gene_id: 79823
downstream_gene_id: 100506108
strongest_risk_snp: rs528301
snps: rs528301
snp_id_current: 528301
context: Intergenic
pvalue_mlog: 5.301029995663981
platform: Illumina [805,814]
cnv: N
initial_samplesize:
818 European ancestry cases, 1,396 European ancestry controls, 449 African American cases, 480 African American controls


dbdate: 2012-04-28
author: Boraska V
date: 2012-03-29
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/22479309
trait: Brachial circumference
initial_samplesize: 18,753 European ancestry individuals
replication_samplesize: 3,623 European ancestry individuals
region: 7q21.12
chrom: 7
reported_genes: DMTF1, GRM3
mapped_gene: KIAA1324L - DMTF1
upstream_gene_id: 222223
downstream_gene_id: 9988
strongest_risk_snp: rs1476587
strongest_risk_allele: G
snps: rs1476587
snp_id_current: 1476587
context: Intergenic
pvalue_mlog: 5.154901959985742
ci_95: [0.16-0.41] unit increase
platform: Affymetrix & Illumina [2,238,430] (imputed)
cnv: N
study:
Genome-wide association study to identify common variants associated with brachial circumference: a meta-analysis of 14 cohorts.


dbdate: 2012-05-10
author: Dastani Z
date: 2012-03-29
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22479202
trait: Adiponectin levels
initial_samplesize: 29,347 European ancestry individuals
replication_samplesize: 10,536 European ancestry individuals
region: 1p36.11
chrom: 1
mapped_gene: IFNLR1 - GRHL3
upstream_gene_id: 163702
downstream_gene_id: 57822
strongest_risk_snp: rs10794657
strongest_risk_allele: G
snps: rs10794657
snp_id_current: 10794657
context: Intergenic
pvalue_mlog: 6.698970004336019
ci_95: [NR] unit increase
platform: Affymetrix & Illumina [NR](imputed)
cnv: N
study:
Novel loci for adiponectin levels and their influence on type 2 diabetes and metabolic traits: a multi-ethnic meta-analysis of 45,891 individuals.


dbdate: 2012-05-10
author: Dastani Z
date: 2012-03-29
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22479202
trait: Adiponectin levels
region: 1q41
chrom: 1
reported_genes: LYPLAL1
mapped_gene: RIMKLBP2 - ZC3H11B
upstream_gene_id: 100422371
downstream_gene_id: 643136
strongest_risk_snp: rs2791553
strongest_risk_allele: G
snps: rs2791553
snp_id_current: 2791553
context: Intergenic
pvalue_mlog: 6.30102999566398
ci_95: [0.012-0.028] unit decrease
platform: Affymetrix & Illumina [NR] (imputed)
cnv: N
initial_samplesize:
29,347 European ancestry individuals, 4,232 African American individuals, 1,776 Filipino ancestry individuals


dbdate: 2012-04-28
author: Imamura M
date: 2012-03-28
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22456796
trait: Type 2 diabetes
initial_samplesize: 4,470 Japanese ancestry cases, 3,071 Japanese ancestry controls
replication_samplesize: 7,605 Japanese ancestry cases, 3,534 Japanese ancestry controls
region: 8p11.21
chrom: 8
reported_genes: ANK1
mapped_gene: ANK1;MIR486
snp_gene_ids: 286;619554
strongest_risk_snp: rs515071
snps: rs515071
snp_id_current: 515071
context: intron;nearGene-5
pvalue_mlog: 8
ci_95: [1.12-1.25]
platform: NR [2,229,890] (imputed)
cnv: N
study:
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations.


dbdate: 2012-04-28
author: Kim HC
date: 2012-03-27
journal: Breast Cancer Res
link: http://www.ncbi.nlm.nih.gov/pubmed/22452962
trait: Breast cancer
initial_samplesize: 2,273 Korean ancestry cases, 2,052 Korean ancestry controls
replication_samplesize: 4,049 Korean ancestry cases, 3,845 Korean ancestry controls
region: 2q34
chrom: 2
reported_genes: ERBB4
mapped_gene: ERBB4
snp_gene_ids: 2066
strongest_risk_snp: rs13393577
strongest_risk_allele: T
snps: rs13393577
snp_id_current: 13393577
context: intron
pvalue_mlog: 13.04575749056067
ci_95: [1.37-1.70]
platform: Affymetrix [555,525]
cnv: N
study:
A genome-wide association study identifies a breast cancer risk variant in ERBB4 at 2q34: results from the Seoul Breast Cancer Study.


dbdate: 2012-04-25
author: Lee YC
date: 2012-03-25
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22446961
trait: Kawasaki disease
initial_samplesize: 622 Taiwanese Han Chinese ancestry cases, 1,107 Taiwanese Han Chinese ancestry controls
replication_samplesize: 261 Taiwanese Han Chinese ancestry cases, 550 Taiwanese Han Chinese ancestry controls
region: 3q23
chrom: 3
reported_genes: COPB2
mapped_gene: PISRT1 - MRPS22
upstream_gene_id: 140464
downstream_gene_id: 56945
strongest_risk_snp: rs4894410
strongest_risk_allele: G
snps: rs4894410
snp_id_current: 4894410
context: Intergenic
pvalue_mlog: 5.096910013008055
ci_95: [1.498-2.925]
platform: Affymetrix [716,935]
cnv: N
study:
Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis.


dbdate: 2012-04-27
author: Okada Y
date: 2012-03-25
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22446963
trait: Rheumatoid arthritis
initial_samplesize: 4,074 Japanese ancestry cases, 16,891 Japanese ancestry controls
replication_samplesize: 5,277 Japanese ancestry cases, 21,684 Japanese ancestry controls
region: 2p15
chrom: 2
reported_genes: B3GNT2
mapped_gene: MIR5192 - TMEM17
upstream_gene_id: 100847087
downstream_gene_id: 200728
strongest_risk_snp: rs11900673
strongest_risk_allele: T
snps: rs11900673
snp_id_current: 11900673
context: Intergenic
pvalue_mlog: 8
ci_95: [1.07-1.15]
platform: Affymetrix & Illumina [1,948,139]
cnv: N
study:
Meta-analysis identifies nine new loci associated with rheumatoid arthritis in the Japanese population.


dbdate: 2012-04-20
author: Kurose K
date: 2012-03-23
journal: Psychiatry Res
link: http://www.ncbi.nlm.nih.gov/pubmed/22445761
trait: Sexual dysfunction (SSRI/SNRI-related)
initial_samplesize: 201 Japanese ancestry individuals
region: 14q21.3
chrom: 14
reported_genes: MDGA2
mapped_gene: MDGA2
snp_gene_ids: 161357
strongest_risk_snp: rs1160351
strongest_risk_allele: T
snps: rs1160351
snp_id_current: 1160351
context: intron
pvalue_mlog: 6.522878745280337
ci_95: [1.79-4.76]
platform: Affymetrix [186,320]
cnv: N
study:
Genome-wide association study of SSRI/SNRI-induced sexual dysfunction in a Japanese cohort with major depression.


dbdate: 2012-04-06
author: Osman W
date: 2012-03-22
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22419738
trait: Glaucoma (primary open-angle)
initial_samplesize: 1,394 Japanese ancestry cases, 6,599 Japanese ancestry controls
replication_samplesize: 1,802 Japanese ancestry cases, 7,212 Japanese ancestry controls
region: 9p21.3
chrom: 9
reported_genes: CDKN2B
mapped_gene: CDKN2B;CDKN2B-AS1
snp_gene_ids: 1030;100048912
strongest_risk_snp: rs1063192
strongest_risk_allele: T
snps: rs1063192
snp_id_current: 1063192
context: UTR-3;intron
pvalue_mlog: 10.30102999566398
ci_95: [1.22-1.43]
platform: Illumina [602,216]
cnv: N
study:
A genome-wide association study in the Japanese population confirms 9p21 and 14q23 as susceptibility loci for primary open angle glaucoma.


dbdate: 2012-06-18
author: Major JM
date: 2012-03-21
journal: J Nutr
link: http://www.ncbi.nlm.nih.gov/pubmed/22437554
trait: Response to Vitamin E supplementation
initial_samplesize: 2,112 European ancestry individuals
region: 11q23.3
chrom: 11
reported_genes: BUD13, ZNF259, APOA5, LOC100128347, SIK3
mapped_gene: ZPR1
snp_gene_ids: 8882
strongest_risk_snp: rs964184
strongest_risk_allele: G
snps: rs964184
snp_id_current: 964184
context: intron
pvalue_mlog: 11.52287874528034
ci_95: [0.050-0.090] mg/L increase
platform: Illumina [549,989]
cnv: N
study:
Genome-wide association study identifies three common variants associated with serologic response to vitamin E supplementation in men.


dbdate: 2012-04-18
author: Wang KS
date: 2012-03-16
journal: Gene
link: http://www.ncbi.nlm.nih.gov/pubmed/22446040
trait: Body mass index
initial_samplesize: 5,218 European ancestry individuals
replication_samplesize: 762 European ancestry individuals
region: 5p15.2
chrom: 5
reported_genes: ROPN1L
mapped_gene: ROPN1L;LOC101929379
snp_gene_ids: 83853;101929379
strongest_risk_snp: rs2967951
strongest_risk_allele: T
snps: rs2967951
snp_id_current: 2967951
context: intron;missense
pvalue_mlog: 5.999999999999999
ci_95: [NR] unit increase
platform: Illumina [up to 520,531]
cnv: N
study:
A novel locus for body mass index on 5p15.2: a meta-analysis of two genome-wide association studies.


dbdate: 2012-05-18
author: Lill CM
date: 2012-03-15
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22438815
trait: Parkinson's disease
initial_samplesize: 2,197 Other ancestry cases, 2,061 Other ancestry controls
replication_samplesize: Up to 98,080 individuals of European and Asian ancestry
region: 4p16.3
chrom: 4
reported_genes: GAK, DGKQ
mapped_gene: DGKQ
snp_gene_ids: 1609
strongest_risk_snp: rs11248060
snps: rs11248060
snp_id_current: 11248060
context: intron
pvalue_mlog: 11.52287874528034
ci_95: [1.15-1.27]
platform: Illumina and Perlegen [7,123,920] (imputed)
cnv: N
study:
Comprehensive research synopsis and systematic meta-analyses in Parkinson's disease genetics: The PDGene database.


dbdate: 2012-04-18
author: Lopez LM
date: 2012-03-15
journal: Neurobiol Aging
link: http://www.ncbi.nlm.nih.gov/pubmed/22425255
trait: White matter integrity
initial_samplesize: 535 European ancestry individuals
region: 16q23.1
chrom: 16
reported_genes: ADAMTS18
mapped_gene: ADAMTS18
snp_gene_ids: 170692
strongest_risk_snp: rs7192208
strongest_risk_allele: G
snps: rs7192208
snp_id_current: 7192208
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [0.29-0.68] unit decrease
platform: Illumina [542,050]
cnv: N
study:
A genome-wide search for genetic influences and biological pathways related to the brain's white matter integrity.


dbdate: 2012-04-06
author: Athanasiu L
date: 2012-03-12
journal: Psychiatry Res
link: http://www.ncbi.nlm.nih.gov/pubmed/22417934
trait: Body mass index and cholesterol (psychopharmacological treatment)
region: 8q21.3
chrom: 8
reported_genes: MMP16
mapped_gene: RNA5SP272 - RIPK2
upstream_gene_id: 100873525
downstream_gene_id: 8767
strongest_risk_snp: rs7838490
snps: rs7838490
snp_id_current: 7838490
context: Intergenic
pvalue_mlog: 7.221848749616355
platform: Affymetrix [608,239]
cnv: N
study:
Genome-wide association study identifies genetic loci associated with body mass index and high density lipoprotein-cholesterol levels during psychopharmacological treatment - a cross-sectional naturalistic study.

initial_samplesize:
283 European ancestry schizophrenia cases, 213 European ancestry bipolar disorder cases, 98 European ancestry psychosis cases


dbdate: 2012-04-03
author: Nakano M
date: 2012-03-12
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/22428042
trait: Glaucoma (primary open-angle)
initial_samplesize: 833 Japanese ancestry cases, 686 Japanese ancestry controls
replication_samplesize: 411 Japanese ancestry cases, 289 Japanese ancestry controls
region: 9p21.3
chrom: 9
reported_genes: CDKN2B-AS1
mapped_gene: CDKN2B-AS1
snp_gene_ids: 100048912
strongest_risk_snp: rs7865618
strongest_risk_allele: A
snps: rs7865618
snp_id_current: 7865618
context: intron
pvalue_mlog: 10.04575749056067
ci_95: [1.50-2.12]
platform: Affymetrix [653,519]
cnv: N
study:
Common variants in CDKN2B-AS1 associated with optic-nerve vulnerability of glaucoma identified by genome-wide association studies in Japanese.


dbdate: 2012-03-30
author: Jongjaroenprasert W
date: 2012-03-08
journal: J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22399142
trait: Thyrotoxic hypokalemic periodic paralysis
initial_samplesize: 78 Thai ancestry cases, 74 Thai ancestry controls
replication_samplesize: 28 Thai ancestry cases, 48 Thai ancestry controls
region: 17q24.3
chrom: 17
reported_genes: KCNJ2
mapped_gene: CALM2P1 - CASC17
upstream_gene_id: 100128390
downstream_gene_id: 101928165
strongest_risk_snp: rs623011
strongest_risk_allele: A
snps: rs623011
snp_id_current: 623011
context: Intergenic
pvalue_mlog: 11.39794000867204
ci_95: [3.04-9.83]
platform: Illumina [508,393]
cnv: N
study:
A genome-wide association study identifies novel susceptibility genetic variation for thyrotoxic hypokalemic periodic paralysis.


dbdate: 2012-04-03
author: Qayyum R
date: 2012-03-08
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22423221
trait: Mean platelet volume
initial_samplesize: 16,388 African American individuals
region: 6p22.2
chrom: 6
reported_genes: LRRC16A
mapped_gene: LRRC16A
snp_gene_ids: 55604
strongest_risk_snp: rs12526480
strongest_risk_allele: T
snps: rs12526480
snp_id_current: 12526480
context: intron
pvalue_mlog: 8.045757490560675
ci_95: [2.9-5.88] 10^9 L decrease
platform: Affymetrix & Illumina [~2.2 million](imputed)
cnv: N
study:
A meta-analysis and genome-wide association study of platelet count and mean platelet volume in african americans.


dbdate: 2012-04-03
author: Kristiansson K
date: 2012-03-07
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22399527
trait: Metabolic syndrome
initial_samplesize: 2,637 European ancestry cases, 7,927 European ancestry controls
region: 2q31.1
chrom: 2
reported_genes: G6PC2
mapped_gene: G6PC2
snp_gene_ids: 57818
strongest_risk_snp: rs560887
strongest_risk_allele: G
snps: rs560887
snp_id_current: 560887
context: intron
pvalue_mlog: 25.30102999566398
ci_95: [NR] mmol/l increase
platform: Illumina [1,257,079] (imputed)
cnv: N
study:
Genome-wide screen for metabolic syndrome susceptibility Loci reveals strong lipid gene contribution but no evidence for common genetic basis for clustering of metabolic syndrome traits.


dbdate: 2012-03-27
author: Froguel P
date: 2012-03-05
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/22403646
trait: Haptoglobin levels
initial_samplesize: 631 European ancestry children
replication_samplesize: 2,957 European ancestry family members, 1,434 European ancestry individuals
region: 16q22.2
chrom: 16
reported_genes: HP
mapped_gene: HPR;TXNL4B
snp_gene_ids: 3250;54957
strongest_risk_snp: rs2000999
strongest_risk_allele: A
snps: rs2000999
snp_id_current: 2000999
context: intron;intron
pvalue_mlog: 58.09691001300805
ci_95: [0.12-0.15] g/L decrease (SFS family cohort)
platform: Illumina [318,237]
cnv: N
study:
A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels.


dbdate: 2012-03-20
author: Tanikawa C
date: 2012-03-04
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22387998
trait: Duodenal ulcer
initial_samplesize: 1,043 Japanese ancestry cases, 21,694 Japanese ancestry controls
replication_samplesize: 5,992 Japanese ancestry cases, 3,629 Japanese ancestry controls
region: 8q24.3
chrom: 8
reported_genes: PSCA
mapped_gene: PSCA
snp_gene_ids: 8000
strongest_risk_snp: rs2294008
strongest_risk_allele: C
snps: rs2294008
snp_id_current: 2294008
context: intron
pvalue_mlog: 32.69897000433601
ci_95: [NR]
platform: Illumina [480,327]
cnv: N
study:
A genome-wide association study identifies two susceptibility loci for duodenal ulcer in the Japanese population.


dbdate: 2012-04-03
author: McCormack M
date: 2012-03-01
journal: Pharmacogenomics
link: http://www.ncbi.nlm.nih.gov/pubmed/22379998
trait: Adverse response to lamotrigine and phenytoin
region: 3p14.2
chrom: 3
reported_genes: FHIT
mapped_gene: FHIT
snp_gene_ids: 2272
strongest_risk_snp: rs10510829
snps: rs10510829
snp_id_current: 10510829
context: intron
pvalue_mlog: 6.154901959985743
platform: Illumina [NR]
cnv: N
study:
Genome-wide mapping for clinically relevant predictors of lamotrigine- and phenytoin-induced hypersensitivity reactions.

initial_samplesize:
34 European ancestry lamotrigine-induced hypersensitivity cases, 42 European ancestry phenytoin-induced hypersensitivity cases, 1,296 European ancestry controls


dbdate: 2012-03-20
author: Urabe Y
date: 2012-03-01
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22396660
trait: Nephrolithiasis
initial_samplesize: 904 Japanese ancestry cases, 7,471 Japanese ancestry controls
replication_samplesize: 4,892 Japanese ancestry cases, 9,873 Japanese ancestry controls
region: 5q35.3
chrom: 5
reported_genes: RGS14, SLC34A1,PFN3, F12
mapped_gene: RGS14
snp_gene_ids: 10636
strongest_risk_snp: rs11746443
snps: rs11746443
snp_id_current: 11746443
context: intron
pvalue_mlog: 11.04575749056067
ci_95: [1.13-1.24]
platform: Illumina [556,249]
cnv: N
study:
A genome-wide association study of nephrolithiasis in the Japanese population identifies novel susceptible Loci at 5q35.3, 7p14.3, and 13q14.1.


dbdate: 2012-03-17
author: Deshmukh HA
date: 2012-02-24
journal: J Lipid Res
link: http://www.ncbi.nlm.nih.gov/pubmed/22368281
trait: Response to statin therapy
initial_samplesize: 2,702 European ancestry individuals
replication_samplesize: 2,550 European ancestry individuals
region: 6q26
chrom: 6
reported_genes: LPA
mapped_gene: LPA
snp_gene_ids: 4018
strongest_risk_snp: rs10455872
strongest_risk_allele: A
snps: rs10455872
snp_id_current: 10455872
context: intron
pvalue_mlog: 8.999999999999998
ci_95: [0.20-0.36] mmol/L decrease
platform: Perlgen & Illumina [NR] (imputed)
cnv: N
study:
Genome-wide association study of genetic determinants of LDL-c response to atorvastatin therapy: importance of Lp(a).


dbdate: 2012-03-20
author: Guo Y
date: 2012-02-24
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/22384028
trait: Hypertension
initial_samplesize: 315 Hong Kong Chinese ancestry individuals from 111 families
region: 5q31.1
chrom: 5
reported_genes: FSTL4
mapped_gene: MIR1289-2 - C5orf15
upstream_gene_id: 100302134
downstream_gene_id: 56951
strongest_risk_snp: rs6596140
strongest_risk_allele: T
snps: rs6596140
snp_id_current: 6596140
context: Intergenic
pvalue_mlog: 7.045757490560674
platform: Illumina [503,984]
cnv: N
study:
A genome-wide linkage and association scan reveals novel loci for hypertension and blood pressure traits.


dbdate: 2012-03-17
author: Lin X
date: 2012-02-24
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22367966
trait: Vitamin B12 levels
initial_samplesize: 1,999 Han Chinese ancestry individuals
replication_samplesize: 1,496 Chinese ancestry individuals
region: 5q32
chrom: 5
reported_genes: Intergenic
mapped_gene: ASS1P10 - PRELID2
upstream_gene_id: 455
downstream_gene_id: 153768
strongest_risk_snp: rs10515552
snps: rs10515552
snp_id_current: 10515552
context: Intergenic
pvalue_mlog: 7.397940008672037
ci_95: [28.29-59.57] pg/ml increase
platform: Illumina [1,940,245] (imputed)
cnv: N
study:
Genome-wide association study identifies novel loci associated with serum level of vitamin B12 in Chinese men.


dbdate: 2012-03-17
author: Long J
date: 2012-02-23
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22383897
trait: Breast cancer
initial_samplesize: 2,918 Chinese ancestry cases, 2,324 Chinese ancestry controls
replication_samplesize: up to 16,173 East Asian ancestry cases, up to 18,282 East Asian ancestry controls
region: 6q25.1
chrom: 6
reported_genes: TAB2
mapped_gene: UST - TAB2
upstream_gene_id: 10090
downstream_gene_id: 23118
strongest_risk_snp: rs9485372
strongest_risk_allele: G
snps: rs9485372
snp_id_current: 9485372
context: Intergenic
pvalue_mlog: 11.39794000867204
ci_95: [1.09-1.15]
platform: Affymetrix [690,947]
cnv: N
study:
Genome-wide association study in east Asians identifies novel susceptibility loci for breast cancer.


dbdate: 2012-04-28
author: Clark PJ
date: 2012-02-22
journal: J Viral Hepat
link: http://www.ncbi.nlm.nih.gov/pubmed/22497812
trait: Lipid levels in hepatitis C treatment
initial_samplesize: 1,017 European ancestry cases, 207 African American cases, 95 Hispanic cases
region: 19q13.2
chrom: 19
reported_genes: IL28B
mapped_gene: IFNL3P1 - IFNL3
upstream_gene_id: 100421129
downstream_gene_id: 282617
strongest_risk_snp: rs12980275
snps: rs12980275
snp_id_current: 12980275
context: Intergenic
pvalue_mlog: 16.30102999566398
platform: Illumina [565,759]
cnv: N
study:
Interleukin 28B polymorphisms are the only common genetic variants associated with low-density lipoprotein cholesterol (LDL-C) in genotype-1 chronic hepatitis C and determine the association between LDL-C and treatment response.


dbdate: 2012-03-30
author: Greenwood TA
date: 2012-02-22
journal: Biol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/22365631
trait: Temperament (bipolar disorder)
initial_samplesize: 1,263 European ancestry cases, 1,434 European ancestry controls
region: 12q15
chrom: 12
reported_genes: MDM1
mapped_gene: MDM1 - PSMC6P2
upstream_gene_id: 56890
downstream_gene_id: 160410
strongest_risk_snp: rs416350
snps: rs416350
snp_id_current: 416350
context: Intergenic
pvalue_mlog: 7.397940008672037
ci_95: [NR] unit increase
platform: Affymetrix [703,012]
cnv: N
study:
Genome-wide association study of temperament in bipolar disorder reveals significant associations with three novel Loci.


dbdate: 2012-03-30
author: Thompson SD
date: 2012-02-21
journal: Arthritis Rheum
link: http://www.ncbi.nlm.nih.gov/pubmed/22354554
trait: Arthritis (juvenile idiopathic)
initial_samplesize: 814 European ancestry cases, 658 European ancestry controls, 2,400 controls
replication_samplesize: 1,744 European ancestry cases, 7,010 European ancestry controls
region: 3q13.33
chrom: 3
reported_genes: C3orf1
mapped_gene: TIMMDC1
snp_gene_ids: 51300
strongest_risk_snp: rs4688011
strongest_risk_allele: T
snps: rs4688011
snp_id_current: 4688011
context: intron
pvalue_mlog: 7
ci_95: [1.13-1.33]
platform: Affmyetrix [561,137]
cnv: N
study:
Genome-wide association analysis of juvenile idiopathic arthritis identifies a new susceptibility locus at chromosomal region 3q13.


dbdate: 2012-03-19
author: Wen W
date: 2012-02-19
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22344219
study: Meta-analysis identifies common variants associated with body mass index in east Asians.
trait: Body mass index
replication_samplesize: 53,215 East Asian ancestry results, 2,118 Malay ancestry individuals
region: 19q13.32
chrom: 19
reported_genes: GIPR, QPCTL
mapped_gene: GIPR
snp_gene_ids: 2696
strongest_risk_snp: rs11671664
strongest_risk_allele: G
snps: rs11671664
snp_id_current: 11671664
context: intron
pvalue_mlog: 13.22184874961636
ci_95: [2.73-5.71] % increase
platform: Affymetrix & Illumina [2,474,474] (imputed)
cnv: N
initial_samplesize:
22,762 East Asian ancestry individuals, 2,522 Malay ancestry individuals, 2,431 Chinese, Malay and Asian Indian ancestry individuals


dbdate: 2012-03-13
author: Bakken TE
date: 2012-02-16
journal: Proc Natl Acad Sci U S A
link: http://www.ncbi.nlm.nih.gov/pubmed/22343285
trait: Cortical structure
initial_samplesize: 421 European ancestry individuals
replication_samplesize: 760 European ancestry individuals
region: 20p12.3
chrom: 20
reported_genes: GPCPD1
mapped_gene: GPCPD1
snp_gene_ids: 56261
strongest_risk_snp: rs238295
snps: rs238295
snp_id_current: 238295
context: intron
pvalue_mlog: 8.221848749616356
platform: Affymetrix [597,198]
cnv: N
study:
Association of common genetic variants in GPCPD1 with scaling of visual cortical surface area in humans.


dbdate: 2012-03-27
author: Demirkan A
date: 2012-02-16
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22359512
trait: Phospholipid levels (plasma)
initial_samplesize: 4,034 European ancestry individuals
region: 11q12.2
chrom: 11
reported_genes: FADS1, FADS2, FADS3
mapped_gene: TMEM258
snp_gene_ids: 746
strongest_risk_snp: rs102275
snps: rs102275
snp_id_current: 102275
context: intron
pvalue_mlog: 203
ci_95: [0.80-23.0] % increase
platform: Illumina [NR] (imputed)
cnv: N
study:
Genome-wide association study identifies novel loci associated with circulating phospho- and sphingolipid concentrations.


dbdate: 2012-03-13
author: Paternoster L
date: 2012-02-16
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22341974
trait: Facial morphology
initial_samplesize: 2,185 European ancestry adolescents
replication_samplesize: 1,622 European ancestry adolescents
region: 2q36.1
chrom: 2
reported_genes: PAX3
mapped_gene: PAX3
snp_gene_ids: 5077
strongest_risk_snp: rs7559271
strongest_risk_allele: G
snps: rs7559271
snp_id_current: 7559271
context: intron
pvalue_mlog: 15.39794000867204
ci_95: [0.30-0.48] mm increase
platform: Illumina [2,543,887] (imputed)
cnv: N
study:
Genome-wide association study of three-dimensional facial morphology identifies a variant in PAX3 associated with nasion position.


dbdate: 2012-03-14
author: Chasman DI
date: 2012-02-13
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22331829
trait: Response to statin therapy (LDL-C)
initial_samplesize: 6,989 European ancestry individuals
region: 1p32.3
chrom: 1
reported_genes: PCSK9
mapped_gene: PCSK9
snp_gene_ids: 255738
strongest_risk_snp: rs11591147
snps: rs11591147
snp_id_current: 11591147
context: missense
pvalue_mlog: 8.301029995663981
ci_95: [3.43-6.57] mg/dL decrease
platform: Illumina [814,418]
cnv: N
study:
Genetic determinants of statin-induced low-density lipoprotein cholesterol reduction: the Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin (JUPITER) trial.


dbdate: 2012-03-08
author: Cha PC
date: 2012-02-09
journal: J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22318345
trait: Gallbladder cancer
initial_samplesize: 41 Japanese ancestry cases, 866 Japanese ancestry controls
replication_samplesize: 30 Japanese ancestry cases, 898 Japanese ancestry controls
region: 18q21.2
chrom: 18
reported_genes: DCC
mapped_gene: DCC
snp_gene_ids: 1630
strongest_risk_snp: rs7504990
strongest_risk_allele: A
snps: rs7504990
snp_id_current: 7504990
context: intron
pvalue_mlog: 7.154901959985742
ci_95: [3.43-14.08]
platform: Illumina [425,706] (imputed)
cnv: N
study:
A genome-wide association study identifies SNP in DCC is associated with gallbladder cancer in the Japanese population.


dbdate: 2012-03-03
author: Kim SJ
date: 2012-02-09
journal: Circ J
link: http://www.ncbi.nlm.nih.gov/pubmed/22322875
trait: Hypertension risk in short sleep duration
initial_samplesize: 4,965 Korean ancestry individuals
region: 1p34.1
chrom: 1
reported_genes: JMJD2A
mapped_gene: KDM4A
snp_gene_ids: 9682
strongest_risk_snp: rs660899
snps: rs660899
snp_id_current: 660899
context: intron
pvalue_mlog: 5.397940008672037
ci_95: [3.12-16.70]
platform: Affymetrix [334,750]
cnv: N
study:
Genetic association of short sleep duration with hypertension incidence--a 6-year follow-up in the Korean genome and epidemiology study.


dbdate: 2012-03-08
author: Davies RW
date: 2012-02-07
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22319020
trait: Coronary heart disease
initial_samplesize: 7,123 European ancestry cases, 6,826 European ancestry controls
replication_samplesize: 5,211 European ancestry cases, 5,821 European ancestry controls
region: 6p21.33
chrom: 6
reported_genes: HCG27, HLA-C
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs3869109
strongest_risk_allele: G
snps: rs3869109
snp_id_current: 3869109
pvalue_mlog: 8.999999999999998
ci_95: [NR]
platform: Affymetrix [~5 million] (imputed)
cnv: N
study:
A genome-wide association study for coronary artery disease identifies a novel susceptibility locus in the major histocompatibility complex.


dbdate: 2012-03-13
author: Man M
date: 2012-02-07
journal: Pharmacogenomics J
link: http://www.ncbi.nlm.nih.gov/pubmed/22310353
trait: Treatment response for severe sepsis
initial_samplesize: 1,446 individuals
region: 1q43
chrom: 1
reported_genes: KRT18P32
mapped_gene: MIPEPP2 - RPL39P10
upstream_gene_id: 100130099
downstream_gene_id: 100129952
strongest_risk_snp: rs1915279
snps: rs1915279
snp_id_current: 1915279
context: Intergenic
pvalue_mlog: 5.698970004336018
platform: Illumina [856,627]
cnv: N
study:
Beyond single-marker analyses: mining whole genome scans for insights into treatment responses in severe sepsis.


dbdate: 2012-03-09
author: Bellenguez C
date: 2012-02-05
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22306652
trait: Stroke
initial_samplesize: 3,548 European ancestry cases, 5,972 European ancestry controls
replication_samplesize: 6,594 European ancestry cases, 34,864 European ancestry controls
region: 7p21.1
chrom: 7
reported_genes: HDAC9
mapped_gene: HDAC9
snp_gene_ids: 9734
strongest_risk_snp: rs11984041
strongest_risk_allele: A
snps: rs11984041
snp_id_current: 11984041
context: intron
pvalue_mlog: 10.69897000433602
ci_95: [1.28-1.57]
platform: Illumina [495,851]
cnv: N
study:
Genome-wide association study identifies a variant in HDAC9 associated with large vessel ischemic stroke.


dbdate: 2012-03-09
author: Thye T
date: 2012-02-05
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22306650
study: Common variants at 11p13 are associated with susceptibility to tuberculosis.
trait: Tuberculosis
initial_samplesize: 1,329 African ancestry cases, 1,847 African ancestry controls
region: 11p13
chrom: 11
reported_genes: WT1
mapped_gene: RCN1 - WT1
upstream_gene_id: 5954
downstream_gene_id: 7490
strongest_risk_snp: rs2057178
snps: rs2057178
snp_id_current: 2057178
context: Intergenic
pvalue_mlog: 10.52287874528034
ci_95: [1.01-1.22] Russian samples
platform: Affymetrix [793,964]
cnv: N
replication_samplesize:
2,024 African ancestry cases, 5,154 African ancestry controls, 1,025 Indonesian ancestry cases, 983 Indonesian ancestry controls, 4,441 European ancestry cases, 5,874 European ancestry controls


dbdate: 2012-03-10
author: Huang J
date: 2012-02-01
journal: Eur J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22293688
trait: Crohn's disease
initial_samplesize: 16,179 European ancestry individuals
region: 1p31.3
chrom: 1
reported_genes: IL23R
mapped_gene: IL23R
snp_gene_ids: 149233
strongest_risk_snp: rs11209026
snps: rs11209026
snp_id_current: 11209026
context: missense
pvalue_mlog: 20.39794000867204
ci_95: [2.91-3.44]
platform: NR [6,233,112] (imputed)
cnv: N
study:
1000 Genomes-based imputation identifies novel and refined associations for the Wellcome Trust Case Control Consortium phase 1 Data.


dbdate: 2012-02-25
author: Ryu J
date: 2012-01-30
journal: Hum Mutat
link: http://www.ncbi.nlm.nih.gov/pubmed/22290723
trait: Glycated hemoglobin levels
initial_samplesize: 4,275 Korean ancestry individuals
replication_samplesize: 3,782 Korean ancestry individuals
region: 6p22.3
chrom: 6
reported_genes: CDKAL1
mapped_gene: CDKAL1
snp_gene_ids: 54901
strongest_risk_snp: rs7747752
strongest_risk_allele: C
snps: rs7747752
snp_id_current: 7747752
context: intron
pvalue_mlog: 11
ci_95: [NR] % decrease
platform: Affymetrix [1,693,116] (imputed)
cnv: N
study:
Association of glycosylated hemoglobin with the gene encoding CDKAL1 in the Korean Association Resource (KARE) study.


dbdate: 2012-03-23
author: Kiyotani K
date: 2012-01-29
journal: Pharmacogenet Genomics
link: http://www.ncbi.nlm.nih.gov/pubmed/22293537
trait: Response to gemcitabine in pancreatic cancer
initial_samplesize: 21 Japanese ancestry adverse reaction cases, 58 Japanese ancestry non-adverse reaction individuals
replication_samplesize: 33 Japanese ancestry adverse reaction cases, 62 Japanese ancestry non-adverse reaction individuals
region: 9q21.33
chrom: 9
reported_genes: DAPK1
mapped_gene: DAPK1
snp_gene_ids: 1612
strongest_risk_snp: rs11141915
strongest_risk_allele: T
snps: rs11141915
snp_id_current: 11141915
context: intron
pvalue_mlog: 5.999999999999999
ci_95: [2.21-7.62]
platform: Illumina [470,064]
cnv: N
study:
A genome-wide association study identifies four genetic markers for hematological toxicities in cancer patients receiving gemcitabine therapy.


dbdate: 2012-02-25
author: Cusanovich DA
date: 2012-01-27
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22286170
trait: Lymphocyte counts
initial_samplesize: 462 Hutterite individuals
region: 1p32.2
chrom: 1
reported_genes: PRKAA2
mapped_gene: PRKAA2
snp_gene_ids: 5563
strongest_risk_snp: rs2746347
snps: rs2746347
snp_id_current: 2746347
context: intron
pvalue_mlog: 6.397940008672037
platform: Affymetrix [279,749]
cnv: N
study:
The combination of a genome-wide association study of lymphocyte count and analysis of gene expression data reveals novel asthma candidate genes.


dbdate: 2012-02-23
author: Low SK
date: 2012-01-27
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22286173
trait: Intracranial aneurysm
initial_samplesize: 1,383 Japanese ancestry cases, 5,484 Japanese ancestry controls
replication_samplesize: 1,048 Japanese ancestry cases, 7,212 Japanese ancestry controls
region: 4q31.22
chrom: 4
reported_genes: EDNRA
mapped_gene: EDNRA
snp_gene_ids: 1909
strongest_risk_snp: rs6842241
strongest_risk_allele: C
snps: rs6842241
snp_id_current: 6842241
context: nearGene-5
pvalue_mlog: 8
ci_95: [1.161-1.343]
platform: Illumina [565,149]
cnv: N
study:
Genome-wide association study for intracranial aneurysm in the Japanese population identifies three candidate susceptible loci and a functional genetic variant at EDNRA.


dbdate: 2012-02-23
author: Urayama KY
date: 2012-01-27
journal: J Natl Cancer Inst
link: http://www.ncbi.nlm.nih.gov/pubmed/22286212
trait: Hodgkin's lymphoma
initial_samplesize: 1,200 European ancestry cases, 6,417 European ancestry controls
replication_samplesize: 563 European ancestry cases, 613 European ancestry controls
region: 6p21.33
chrom: 6
reported_genes: MICB
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs2248462
snps: rs2248462
snp_id_current: 2248462
pvalue_mlog: 15.15490195998574
ci_95: [1.45-1.85]
platform: Illumina [502,514]
cnv: N
study:
Genome-wide association study of classical Hodgkin lymphoma and Epstein-Barr virus status-defined subgroups.


dbdate: 2012-02-22
author: Naitza S
date: 2012-01-26
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22291609
trait: Inflammatory biomarkers
initial_samplesize: 4,694 European ancestry individuals
replication_samplesize: 1,392 European ancestry individuals
region: 9q34.2
chrom: 9
reported_genes: ABO
mapped_gene: ABO
snp_gene_ids: 28
strongest_risk_snp: rs643434
strongest_risk_allele: A
snps: rs643434
snp_id_current: 643434
context: intron
pvalue_mlog: 24.04575749056067
platform: Affymetrix [~1.9 million] (imputed)
cnv: N
study:
A genome-wide association scan on the levels of markers of inflammation in Sardinians reveals associations that underpin its complex regulation.


dbdate: 2012-02-21
author: Okada Y
date: 2012-01-26
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22291604
trait: Systemic lupus erythematosus
initial_samplesize: 891 Japanese ancestry cases, 3,384 Japanese ancestry controls
replication_samplesize: 1,387 Japanese ancestry cases, 28,564 Japanese ancestry controls
region: 4q21.3
chrom: 4
reported_genes: AFF1
mapped_gene: AFF1
snp_gene_ids: 4299
strongest_risk_snp: rs340630
strongest_risk_allele: A
snps: rs340630
snp_id_current: 340630
context: intron
pvalue_mlog: 8.096910013008056
ci_95: [1.14-1.30]
platform: Illumina [430,797]
cnv: N
study:
A genome-wide association study identified AFF1 as a susceptibility locus for systemic lupus eyrthematosus in Japanese.


dbdate: 2012-02-10
author: Stolk L
date: 2012-01-22
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22267201
trait: Menopause (age at onset)
initial_samplesize: 38,968 European ancestry females
replication_samplesize: Up to 14,435 European ancestry females
region: 1p34.3
chrom: 1
reported_genes: RHBDL2
mapped_gene: RHBDL2
snp_gene_ids: 54933
strongest_risk_snp: rs4246511
strongest_risk_allele: T
snps: rs4246511
snp_id_current: 4246511
context: intron
pvalue_mlog: 16.04575749056067
ci_95: [0.18-0.3] years increase
platform: Affymetrix & Illumina [2,551,160] (imputed)
cnv: N
study:
Meta-analyses identify 13 loci associated with age at menopause and highlight DNA repair and immune pathways.


dbdate: 2012-03-20
author: Zhang CK
date: 2012-01-19
journal: Am J Hematol
link: http://www.ncbi.nlm.nih.gov/pubmed/22388998
trait: Gaucher disease severity
initial_samplesize: 139 Ashkenazi Jewish cases
region: 8p23.3
chrom: 8
reported_genes: CLN8
mapped_gene: CLN8 - MIR3674
upstream_gene_id: 2055
downstream_gene_id: 100500912
strongest_risk_snp: rs11986414
strongest_risk_allele: A
snps: rs11986414
snp_id_current: 11986414
context: Intergenic
pvalue_mlog: 5.999999999999999
ci_95: [2.19-6.31]
platform: Illumina [540,902]
cnv: N
study:
Genome-wide association study of N370S homozygous Gaucher disease reveals the candidacy of CLN8 gene as a genetic modifier contributing to extreme phenotypic variation.


dbdate: 2012-04-25
author: Oudot-Mellakh T
date: 2012-01-16
journal: Br J Haematol
link: http://www.ncbi.nlm.nih.gov/pubmed/22443383
trait: Hemostatic factors and hematological phenotypes
initial_samplesize: 951 European ancestry individuals
region: 1q24.2
chrom: 1
reported_genes: F5
mapped_gene: F5
snp_gene_ids: 2153
strongest_risk_snp: rs2420371
strongest_risk_allele: G
snps: rs2420371
snp_id_current: 2420371
context: intron
pvalue_mlog: 79.39794000867202
ci_95: [1.04-1.28] unit decrease
platform: Illumina [472,123]
cnv: N
study:
Genome wide association study for plasma levels of natural anticoagulant inhibitors and protein C anticoagulant pathway: the MARTHA project.


dbdate: 2012-02-09
author: Murray SS
date: 2012-01-11
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/22247754
trait: Life threatening arrhythmia
initial_samplesize: 607 European ancestry cases, 297 European ancestry controls
region: 15q13.1
chrom: 15
reported_genes: KIAA0574
mapped_gene: FAM189A1
snp_gene_ids: 23359
strongest_risk_snp: rs11856574
strongest_risk_allele: G
snps: rs11856574
snp_id_current: 11856574
context: intron
pvalue_mlog: 5.301029995663981
platform: Illumina [NR] (imputed)
cnv: N
study:
Genome-wide association of implantable cardioverter-defibrillator activation with life-threatening arrhythmias.


dbdate: 2012-02-08
author: Karns R
date: 2012-01-09
journal: Ann Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22229870
trait: Uric acid levels
initial_samplesize: 1,300 European ancestry individuals
region: 4p16.1
chrom: 4
reported_genes: SLC2A9, WDR1
mapped_gene: SLC2A9
snp_gene_ids: 56606
strongest_risk_snp: rs13129697
strongest_risk_allele: G
snps: rs13129697
snp_id_current: 13129697
context: intron
pvalue_mlog: 18.69897000433602
ci_95: [NR] umol/L decrease
platform: Affymetrix [2,241,249] (imputed)
cnv: N
study:
Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia.


dbdate: 2012-03-10
author: Aslibekyan S
date: 2012-01-05
journal: Pharmacogenet Genomics
link: http://www.ncbi.nlm.nih.gov/pubmed/22228203
trait: Inflammatory biomarkers
initial_samplesize: 1,092 European ancestry individuals
region: 10p15.1
chrom: 10
reported_genes: IL2RA
mapped_gene: IL15RA - IL2RA
upstream_gene_id: 3601
downstream_gene_id: 3559
strongest_risk_snp: rs7911500
snps: rs7911500
snp_id_current: 7911500
context: Intergenic
pvalue_mlog: 8.301029995663981
platform: Affymetrix [2,543,887](imputed)
cnv: N
study:
A genome-wide association study of inflammatory biomarker changes in response to fenofibrate treatment in the Genetics of Lipid Lowering Drug and Diet Network.


dbdate: 2012-03-31
author: Tao S
date: 2012-01-04
journal: Carcinogenesis
link: http://www.ncbi.nlm.nih.gov/pubmed/22219177
trait: Prostate cancer (gene x gene interaction)
initial_samplesize: 4,723 European ancestry cases, 4,792 European ancestry controls
region: 15q21.1
chrom: 15
reported_genes: CEP152
mapped_gene: CEP152
snp_gene_ids: 22995
strongest_risk_snp: rs784411
snps: rs784411
snp_id_current: 784411
context: intron
pvalue_mlog: 7
ci_95: [1.25-1.61]
platform: Affymetrix & Illumina [1,117,531] (imputed)
cnv: N
study:
A genome-wide search for loci interacting with known prostate cancer risk-associated genetic variants.


dbdate: 2012-10-16
author: O'Donnell PH
date: 2012-01-03
journal: Cancer
link: http://www.ncbi.nlm.nih.gov/pubmed/22864933
study: Identification of novel germline polymorphisms governing capecitabine sensitivity.
trait: Capecitabine sensitivity
region: 1q23.3
chrom: 1
reported_genes: Intergenic
mapped_gene: SLAMF7 - LY9
upstream_gene_id: 57823
downstream_gene_id: 4063
strongest_risk_snp: rs576523
snps: rs576523
snp_id_current: 576523
context: Intergenic
pvalue_mlog: 6.698970004336019
platform: NR [~2 million]
cnv: N
initial_samplesize:
Up to 84 East Asian ancestry lymphoblastoid cell lines, up to 164 European ancestry lymphoblastoid cell lines, up to 173 African ancestry lymphoblastoid cell lines, up to 82 African American lymphoblastoid cell lines


dbdate: 2012-01-20
author: Mead S
date: 2011-12-30
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22210626
trait: Prion diseases
region: 20p13
chrom: 20
reported_genes: PRNP
mapped_gene: PRNP
snp_gene_ids: 5621
strongest_risk_snp: rs1799990
snps: rs1799990
snp_id_current: 1799990
context: missense
pvalue_mlog: 6.154901959985743
ci_95: [NR]
platform: Illumina [NR] (imputed)
cnv: N
study:
Genome-wide association study in multiple human prion diseases suggests genetic risk factors additional to PRNP.

initial_samplesize:
1,281 European ancestry cases, 6,015 European ancestry controls, 290 Papua New Guinea cases, 286 Papua New Guinea controls.


dbdate: 2012-01-10
author: Tan A
date: 2011-12-30
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22171074
trait: Triglycerides
initial_samplesize: 1,999 Chinese ancestry individuals
replication_samplesize: 1,496 Chinese ancestry individuals.
region: 8p21.3
chrom: 8
reported_genes: LPL
mapped_gene: LPL
snp_gene_ids: 4023
strongest_risk_snp: rs328
snps: rs328
snp_id_current: 328
context: STOP-GAIN
pvalue_mlog: 8.999999999999998
platform: Illumina [1,940,243] (imputed)
cnv: N
study:
A genome-wide association and gene-environment interaction study for serum triglycerides levels in a healthy Chinese male population.


dbdate: 2012-01-19
author: Hu Z
date: 2011-12-25
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22197933
trait: Non-obstructive azoospermia
initial_samplesize: 981 Chinese ancestry cases, 1,657 Chinese ancestry controls.
replication_samplesize: 1,946 Chinese ancestry cases, 4,077 Chinese ancestry controls.
region: 1p13.3
chrom: 1
reported_genes: PRMT6
mapped_gene: SEPT2P1 - NDE1P1
upstream_gene_id: 100873333
downstream_gene_id: 100422372
strongest_risk_snp: rs12097821
snps: rs12097821
snp_id_current: 12097821
context: Intergenic
pvalue_mlog: 9.221848749616356
ci_95: [1.17-1.34]
platform: Affymetrix [587,347]
cnv: N
study:
A genome-wide association study in Chinese men identifies three risk loci for non-obstructive azoospermia.


dbdate: 2012-01-28
author: Paternoster L
date: 2011-12-25
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22197932
trait: Atopic dermatitis
initial_samplesize: 5,606 European ancestry cases, 20,565 European ancestry controls
replication_samplesize: 5,419 European ancestry cases, 19,833 European ancestry controls
region: 11q13.1
chrom: 11
reported_genes: OVOL1
mapped_gene: AP5B1 - OVOL1
upstream_gene_id: 91056
downstream_gene_id: 5017
strongest_risk_snp: rs479844
strongest_risk_allele: G
snps: rs479844
snp_id_current: 479844
context: Intergenic
pvalue_mlog: 13
ci_95: [1.10-1.18]
platform: Afftmetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Meta-analysis of genome-wide association studies identifies three new risk loci for atopic dermatitis.


dbdate: 2012-01-24
author: Yu XQ
date: 2011-12-25
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22197929
trait: IgA nephropathy
initial_samplesize: 1,434 Chinese ancestry cases, 4,270 Chinese ancestry controls.
replication_samplesize: 2,703 Chinese ancestry cases, 3,464 Chinese ancestry controls.
region: 8p23.1
chrom: 8
reported_genes: DEFAs
mapped_gene: DEFA9P - DEFA10P
upstream_gene_id: 449492
downstream_gene_id: 449493
strongest_risk_snp: rs2738048
strongest_risk_allele: A
snps: rs2738048
snp_id_current: 2738048
context: Intergenic
pvalue_mlog: 13.52287874528034
ci_95: [1.19-1.35]
platform: Illumina [444,882]
cnv: N
study:
A genome-wide association study in Han Chinese identifies multiple susceptibility loci for IgA nephropathy.


dbdate: 2012-01-27
author: Murabito JM
date: 2011-12-23
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22199011
trait: Ankle-brachial index
initial_samplesize: 41,692 European ancestry individuals
replication_samplesize: 16,717 European ancestry individuals
region: 9p21.3
chrom: 9
reported_genes: CDKN2B
mapped_gene: CDKN2B-AS1;LOC102724137
snp_gene_ids: 100048912;102724137
strongest_risk_snp: rs10757269
strongest_risk_allele: G
snps: rs10757269
snp_id_current: 10757269
context: intron;nearGene-5
pvalue_mlog: 8.045757490560675
ci_95: [0.0029-0.0061] unit decrease
platform: Affymetrix, Illumina & Perlgen [~2.5 million] (imputed)
cnv: N
study:
Association between chromosome 9p21 variants and the ankle-brachial index identified by a meta-analysis of 21 genome-wide association studies.


dbdate: 2012-01-27
author: Chen DT
date: 2011-12-20
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/22182935
trait: Bipolar disorder
replication_samplesize: 1,115 European ancestry cases, 2,728 European ancestry controls
region: 1p31.1
chrom: 1
reported_genes: PTGFR
mapped_gene: RPL23P3 - ELTD1
upstream_gene_id: 100130630
downstream_gene_id: 64123
strongest_risk_snp: rs4650608
strongest_risk_allele: T
snps: rs4650608
snp_id_current: 4650608
context: Intergenic
pvalue_mlog: 8.096910013008056
platform: Affymetrix & Illumina [748,555]
cnv: N
study:
Genome-wide association study meta-analysis of European and Asian-ancestry samples identifies three novel loci associated with bipolar disorder.

initial_samplesize:
5,568 European ancestry cases, 7,187 European ancestry controls, 1,000 Taiwanese cases, 1,000 Taiwanese controls


dbdate: 2012-01-14
author: Kiyotani K
date: 2011-12-16
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22180457
trait: Response to tamoxifen in breast cancer
initial_samplesize: 240 Japanese ancestry cases
replication_samplesize: 222 Japanese ancestry cases
region: 10q22.3
chrom: 10
reported_genes: C10orf11
mapped_gene: C10orf11
snp_gene_ids: 83938
strongest_risk_snp: rs10509373
strongest_risk_allele: C
snps: rs10509373
snp_id_current: 10509373
context: intron
pvalue_mlog: 7.221848749616355
ci_95: [2.72-7.51]
platform: Illumina [470,796]
cnv: N
study:
A genome-wide association study identifies locus at 10q22 associated with clinical outcomes of adjuvant tamoxifen therapy for breast cancer patients in Japanese.


dbdate: 2012-01-11
author: Rankinen T
date: 2011-12-15
journal: J Appl Physiol (1985)
link: http://www.ncbi.nlm.nih.gov/pubmed/22174390
trait: Heart rate variability traits
initial_samplesize: 472 European ancestry individuals from 99 families
region: 2p25.1
chrom: 2
reported_genes: YWHAQ
mapped_gene: ADAM17 - YWHAQ
upstream_gene_id: 6868
downstream_gene_id: 10971
strongest_risk_snp: rs6432018
snps: rs6432018
snp_id_current: 6432018
context: Intergenic
pvalue_mlog: 6.096910013008056
platform: Illumina [320,000]
cnv: N
study:
Heritability of submaximal exercise heart rate response to exercise training is accounted for by nine SNPs.


dbdate: 2012-01-31
author: Lingappa JR
date: 2011-12-12
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/22174851
trait: HIV-1 susceptibility
initial_samplesize: 798 African ancestry
region: 16p13.3
chrom: 16
reported_genes: IL32
mapped_gene: IL32 - RNU1-22P
upstream_gene_id: 9235
downstream_gene_id: 100873863
strongest_risk_snp: rs4349147
snps: rs4349147
snp_id_current: 4349147
context: Intergenic
pvalue_mlog: 5.096910013008055
platform: Illumina [990,115]
cnv: N
study:
Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.


dbdate: 2012-01-18
author: Cho YS
date: 2011-12-11
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22158537
trait: Type 2 diabetes
region: 4p16.3
chrom: 4
reported_genes: MAEA
mapped_gene: MAEA
snp_gene_ids: 10296
strongest_risk_snp: rs6815464
strongest_risk_allele: C
snps: rs6815464
snp_id_current: 6815464
context: intron
pvalue_mlog: 19.69897000433602
ci_95: [1.10�1.16]
platform: Affymetrix & Illumina [2,626,356](imputed)
cnv: N
study:
Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians.

initial_samplesize:
4,026 Chinese ancestry cases, 1,042 Korean ancestry cases, 794 Malaysian ancestry cases, 931 Japanese ancestry cases, 159 Filipino ancestry cases, 4,654 Chinese ancestry controls, 2,943 Korean ancestry controls, 1,240 Malaysian ancestry controls, 1,404 Japanese ancestry controls, 1,624 Filipino ancestry controls.

replication_samplesize:
9,723 Japanese ancestry cases, 1,815 Korean ancestry cases, 6,589 Chinese ancestry cases, 8,974 Japanese ancestry controls, 2,066 Korean ancestry controls, Chinese ancestry controls.


dbdate: 2012-01-18
author: Wu C
date: 2011-12-11
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22158540
trait: Pancreatic cancer
initial_samplesize: 981 Chinese ancestry cases, 1,991 Chinese ancestry contorls.
replication_samplesize: 2,603 Chinese ancestry cases, 2,877 Chinese ancestry controls.
region: 21q21.3
chrom: 21
reported_genes: BACH1
mapped_gene: BACH1
snp_gene_ids: 571
strongest_risk_snp: rs372883
strongest_risk_allele: T
snps: rs372883
snp_id_current: 372883
context: intron
pvalue_mlog: 12.69897000433602
ci_95: [1.19-1.33]
platform: Affymetrix [666,141]
cnv: N
study:
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.


dbdate: 2012-01-06
author: Innocenti F
date: 2011-12-05
journal: Clin Cancer Res
link: http://www.ncbi.nlm.nih.gov/pubmed/22142827
trait: Response to gemcitabine in pancreatic cancer
initial_samplesize: 294 European ancestry cases
region: 6p12.2
chrom: 6
reported_genes: IL17F
mapped_gene: IL17F
snp_gene_ids: 112744
strongest_risk_snp: rs763780
strongest_risk_allele: G
snps: rs763780
snp_id_current: 763780
context: missense
pvalue_mlog: 7.522878745280337
ci_95: [2.10-5.10]
platform: Illumina [330,690]
cnv: N
study:
A genome-wide association study of overall survival in pancreatic cancer patients treated with gemcitabine in CALGB 80303.


dbdate: 2012-01-06
author: O'Donnell CJ
date: 2011-12-05
journal: Circulation
link: http://www.ncbi.nlm.nih.gov/pubmed/22144573
trait: Coronary artery calcification
initial_samplesize: 9,961 European ancestry individuals
replication_samplesize: 6,032 European ancestry individuals
region: 9p21.3
chrom: 9
reported_genes: CDKN2B
mapped_gene: UBA52P6 - DMRTA1
upstream_gene_id: 100130239
downstream_gene_id: 63951
strongest_risk_snp: rs1333049
strongest_risk_allele: C
snps: rs1333049
snp_id_current: 1333049
context: Intergenic
pvalue_mlog: 23.52287874528033
ci_95: [0.16-0.24] % increase
platform: Affyemtrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Genome-wide association study for coronary artery calcification with follow-up in myocardial infarction.


dbdate: 2012-01-04
author: Lin Z
date: 2011-12-04
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22138694
trait: Ankylosing spondylitis
initial_samplesize: 1,837 Han Chinese cases, 4,231 Han Chinese controls
replication_samplesize: 2,100 Han Chinese cases, 3,496 Han Chinese controls
region: 5q14.3
chrom: 5
reported_genes: HAPLN1, EDIL3
mapped_gene: RPL13AP14 - EDIL3
upstream_gene_id: 100271278
downstream_gene_id: 10085
strongest_risk_snp: rs4552569
strongest_risk_allele: C
snps: rs4552569
snp_id_current: 4552569
context: Intergenic
pvalue_mlog: 9.045757490560675
ci_95: [1.14-1.29]
platform: Illumina [1,356,350] (imputed)
cnv: N
study:
A genome-wide association study in Han Chinese identifies new susceptibility loci for ankylosing spondylitis.


dbdate: 2011-12-24
author: Fan Q
date: 2011-12-01
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22144915
trait: Corneal astigmatism
region: 4q12
chrom: 4
reported_genes: Intergenic
mapped_gene: RPL22P13
snp_gene_ids: 442108
strongest_risk_snp: rs17084051
strongest_risk_allele: A
snps: rs17084051
snp_id_current: 17084051
pvalue_mlog: 5.698970004336018
ci_95: [1.13-1.29]
platform: Illumina [460,528]
cnv: N
study:
Genome-wide meta-analysis of five Asian cohorts identifies PDGFRA as a susceptibility locus for corneal astigmatism.

initial_samplesize:
1,231 Chinese ancestry cases, 785 Chinese ancestry controls, 1,018 Malaysian ancestry cases, 1,220 Malaysian ancestry controls

replication_samplesize:
825 Indian ancestry cases, 1,314 Indian ancestry controls, 760 Chinese ancestry cases, 169 Chinese ancestry controls, 1,191 Chinese ancestry individuals from 397 parent-trios


dbdate: 2013-08-21
author: Irvin MR
date: 2011-12-01
journal: Pharmacogenet Genomics
link: http://www.ncbi.nlm.nih.gov/pubmed/21897333
trait: Fat distribution (HIV)
initial_samplesize: 192 European ancestry male cases
region: 8q21.3
chrom: 8
reported_genes: SLC26A7
mapped_gene: SLC26A7
snp_gene_ids: 115111
strongest_risk_snp: rs921231
strongest_risk_allele: G
snps: rs921231
snp_id_current: 921231
context: intron
pvalue_mlog: 5.999999999999999
platform: Illumina [319,818]
cnv: N
study:
Genes linked to energy metabolism and immunoregulatory mechanisms are associated with subcutaneous adipose tissue distribution in HIV-infected men.


dbdate: 2012-01-11
author: Nam RK
date: 2011-12-01
journal: Cancer Biol Ther
link: http://www.ncbi.nlm.nih.gov/pubmed/22130093
trait: Prostate cancer
initial_samplesize: 316 cases, 229 controls
region: 10q26.12
chrom: 10
reported_genes: Intergenic
mapped_gene: LINC01153 - FGFR2
upstream_gene_id: 101927889
downstream_gene_id: 2263
strongest_risk_snp: rs11199874
snps: rs11199874
snp_id_current: 11199874
context: Intergenic
pvalue_mlog: 9.522878745280336
platform: Affymetrix [443,816]
cnv: N
study:
New variants at 10q26 and 15q21 are associated with aggressive prostate cancer in a genome-wide association study from a prostate biopsy screening cohort.

replication_samplesize:
55 Asian ancestry cases, 1,382 European ancestry cases, 184 African American ancestry cases, 42 Other ancestry cases, 134 Asian ancestry controls, 1,428 European ancestry controls, 127 African American ancestry controls, 87 Other ancestry controls


dbdate: 2011-12-20
author: LeBlanc M
date: 2011-11-28
journal: J Psychiatr Res
link: http://www.ncbi.nlm.nih.gov/pubmed/22126837
trait: Cognitive function
region: 12p12.3
chrom: 12
reported_genes: PTPRO
mapped_gene: PTPRO
snp_gene_ids: 5800
strongest_risk_snp: rs2300290
snps: rs2300290
snp_id_current: 2300290
context: intron
pvalue_mlog: 8
ci_95: [0.73-1.47] unit decrease
platform: Affymetrix [550,291]
cnv: N
study:
Genome-wide study identifies PTPRO and WDR72 and FOXQ1-SUMO1P1 interaction associated with neurocognitive function.

initial_samplesize:
190 European ancestry schizophrenia cases, 157 European ancestry  bipolar disorder cases, 353 European ancestry controls


dbdate: 2011-12-20
author: Guo Y
date: 2011-11-24
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22116939
trait: Epilepsy
initial_samplesize: 504 Han Chinese cases, 2,947 Han Chinese controls
replication_samplesize: 583 Han Chinese cases, 497 Han Chinese controls
region: 1q32.1
chrom: 1
reported_genes: CAMSAP1L1
mapped_gene: CAMSAP2
snp_gene_ids: 23271
strongest_risk_snp: rs2292096
snps: rs2292096
snp_id_current: 2292096
context: intron
pvalue_mlog: 8
ci_95: [NR]
platform: Illumina [461,024]
cnv: N
study:
Two-stage genome-wide association study identifies variants in CAMSAP1L1 as susceptibility loci for epilepsy in Chinese.


dbdate: 2012-01-11
author: Schuh-Huerta SM
date: 2011-11-24
journal: Hum Reprod
link: http://www.ncbi.nlm.nih.gov/pubmed/22116950
trait: Ovarian reserve
initial_samplesize: 232 European ancestry women, 200 African American ancestry women
region: 2p22.3
chrom: 2
reported_genes: MYADML
mapped_gene: SLC25A5P2 - MIR548AD
upstream_gene_id: 344371
downstream_gene_id: 100616475
strongest_risk_snp: rs6543833
snps: rs6543833
snp_id_current: 6543833
context: Intergenic
pvalue_mlog: 7.096910013008055
platform: Affymetrix [677,261]
cnv: N
study:
Genetic variants and environmental factors associated with hormonal markers of ovarian reserve in Caucasian and African American women.


dbdate: 2011-12-17
author: Kho AN
date: 2011-11-19
journal: J Am Med Inform Assoc
link: http://www.ncbi.nlm.nih.gov/pubmed/22101970
trait: Type 2 diabetes
region: 10q25.2
chrom: 10
reported_genes: TCF7L2
mapped_gene: TCF7L2
snp_gene_ids: 6934
strongest_risk_snp: rs7903146
strongest_risk_allele: T
snps: rs7903146
snp_id_current: 7903146
context: intron
pvalue_mlog: 14.69897000433602
ci_95: [NR]
platform: Illumina [NR]
cnv: N
study:
Use of diverse electronic medical record systems to identify genetic risk for type 2 diabetes within a genome-wide association study.

initial_samplesize:
2,413 European ancestry cases, 810 African American cases, 2,392 European ancestry controls, 873 African American controls


dbdate: 2011-12-20
author: Lange CM
date: 2011-11-16
journal: Hepatology
link: http://www.ncbi.nlm.nih.gov/pubmed/22095909
trait: Response to hepatitis C treatment
initial_samplesize: 707 European ancestry cases
region: 1p33
chrom: 1
reported_genes: KIAA0494
mapped_gene: EFCAB14
snp_gene_ids: 9813
strongest_risk_snp: rs10789491
strongest_risk_allele: G
snps: rs10789491
snp_id_current: 10789491
context: intron
pvalue_mlog: 5.999999999999999
ci_95: [0.19-0.44] ug/L increase
cnv: N
study:
Serum ferritin levels are associated with a distinct phenotype of chronic hepatitis C poorly responding to pegylated interferon-alpha and ribavirin therapy.


dbdate: 2011-12-17
author: Khor CC
date: 2011-11-13
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22081228
study: Genome-wide association study identifies FCGR2A as a susceptibility locus for Kawasaki disease.
trait: Kawasaki disease
initial_samplesize: 405 European ancestry cases, 6,252 European ancestry controls
region: 1q23.3
chrom: 1
reported_genes: FCGR2A
mapped_gene: FCGR2A
snp_gene_ids: 2212
strongest_risk_snp: rs1801274
strongest_risk_allele: A
snps: rs1801274
snp_id_current: 1801274
context: missense
pvalue_mlog: 10.15490195998574
ci_95: [1.22-1.44]
platform: Illumina [494,236]
cnv: N
replication_samplesize:
1815 European ancestry individuals and 405 non-European ancestry individuals from 740 trios, 139 additional discordant European ancestry siblings, 1,028 East Asian ancestry cases, 1,512 East Asian ancestry controls


dbdate: 2012-01-06
author: Ellinghaus E
date: 2011-11-11
journal: Leukemia
link: http://www.ncbi.nlm.nih.gov/pubmed/22076464
trait: Acute lymphoblastic leukemia (childhood)
initial_samplesize: 419 European ancestry cases, 474 European ancestry controls
replication_samplesize: Up to 1,277 European ancestry cases and 3,061 European ancestry controls
region: 11q12.1
chrom: 11
reported_genes: OR8U8
mapped_gene: OR5AL2P - OR5AL1
upstream_gene_id: 79476
downstream_gene_id: 79482
strongest_risk_snp: rs1945213
snps: rs1945213
snp_id_current: 1945213
context: Intergenic
pvalue_mlog: 7.522878745280337
ci_95: [1.19-1.43]
platform: Affymetrix [355,750]
cnv: N
study:
Identification of germline susceptibility loci in ETV6-RUNX1-rearranged childhood acute lymphoblastic leukemia.


dbdate: 2011-12-03
author: Mitchell GF
date: 2011-11-08
journal: Circ Cardiovasc Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22068335
trait: Aortic stiffness
initial_samplesize: 20,634 European ancestry individuals
replication_samplesize: 5,306 European ancestry individuals
region: 14q32.2
chrom: 14
reported_genes: BCL11B
mapped_gene: C14orf64 - C14orf177
upstream_gene_id: 388011
downstream_gene_id: 283598
strongest_risk_snp: rs7152623
snps: rs7152623
snp_id_current: 7152623
context: Intergenic
pvalue_mlog: 14.52287874528034
ci_95: [0.056-0.096] unit decrease
platform: Affymetrix & Illumina [~2.5 million] (imputed)
cnv: N
study:
Common genetic variation in the 3'-BCL11B gene desert is associated with carotid-femoral pulse wave velocity and excess cardiovascular disease risk: the AortaGen Consortium.


dbdate: 2011-12-14
author: Morisaki H
date: 2011-11-07
journal: Hum Mutat
link: http://www.ncbi.nlm.nih.gov/pubmed/22065538
trait: Adiponectin levels
initial_samplesize: 3,310 Japanese ancestry individuals
region: 16q23.3
chrom: 16
reported_genes: CDH13
mapped_gene: CDH13
snp_gene_ids: 1012
strongest_risk_snp: rs12051272
snps: rs12051272
snp_id_current: 12051272
context: intron
pvalue_mlog: 39.30102999566397
platform: Illumina [348,622]
cnv: N
study:
CDH13 gene coding T-cadherin influences variations in plasma adiponectin levels in the Japanese population.


dbdate: 2011-12-14
author: Sun L
date: 2011-11-07
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/22087292
trait: Femoral neck bone geometry
initial_samplesize: 1,627 Han Chinese individuals
replication_samplesize: 2,286 European ancestry individuals
region: 2p12
chrom: 2
reported_genes: HK2
mapped_gene: HK2
snp_gene_ids: 3099
strongest_risk_snp: rs681900
snps: rs681900
snp_id_current: 681900
context: intron
pvalue_mlog: 5.522878745280337
platform: Affymetrix [689,368]
cnv: N
study:
Bivariate genome-wide association analyses of femoral neck bone geometry and appendicular lean mass.


dbdate: 2011-12-03
author: Bown MJ
date: 2011-11-04
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22055160
trait: Abdominal aortic aneurysm
initial_samplesize: 1,866 cases, 5,435 controls
replication_samplesize: 4,362 cases, 43,747 controls
region: 12q13.3
chrom: 12
reported_genes: LRP1
mapped_gene: LRP1
snp_gene_ids: 4035
strongest_risk_snp: rs1466535
strongest_risk_allele: C
snps: rs1466535
snp_id_current: 1466535
context: intron
pvalue_mlog: 9.301029995663981
ci_95: [1.10-1.21]
platform: Illumina [535,296]
cnv: N
study:
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1.


dbdate: 2011-12-03
author: Foster MC
date: 2011-11-01
journal: BMC Med Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22044751
trait: Renal sinus fat
initial_samplesize: 2,809 European ancestry individuals
region: 12q24.33
chrom: 12
reported_genes: GLT1D1
mapped_gene: SLC15A4 - GLT1D1
upstream_gene_id: 121260
downstream_gene_id: 144423
strongest_risk_snp: rs10744391
strongest_risk_allele: A
snps: rs10744391
snp_id_current: 10744391
context: Intergenic
pvalue_mlog: 5.999999999999999
ci_95: [0.13-0.31] unit decrease
platform: Affymetrix [~2.5 million] (imputed)
cnv: N
study:
Heritability and genome-wide association analysis of renal sinus fat accumulation in the Framingham Heart Study.


dbdate: 2011-12-08
author: Middelberg RP
date: 2011-11-01
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22010049
trait: Gamma gluatamyl transferase levels
initial_samplesize: 12,526 European ancestry individuals
region: 1p36.13
chrom: 1
reported_genes: Intergenic
mapped_gene: EPHA2 - ARHGEF19
upstream_gene_id: 1969
downstream_gene_id: 128272
strongest_risk_snp: rs1497406
strongest_risk_allele: T
snps: rs1497406
snp_id_current: 1497406
context: Intergenic
pvalue_mlog: 7.397940008672037
ci_95: [0.051-0.105] unit decrease
platform: Illumina [2,380,486](imputed)
cnv: N
study:
Loci affecting gamma-glutamyl transferase in adults and adolescents show age &#x000d7; SNP interaction and cardiometabolic disease associations.


dbdate: 2011-12-01
author: Ramasamy A
date: 2011-11-01
journal: J Allergy Clin Immunol
link: http://www.ncbi.nlm.nih.gov/pubmed/22036096
trait: Allergic rhinitis
initial_samplesize: 3,933 European ancestry cases, 8,965 European ancestry controls
region: 11q13.5
chrom: 11
reported_genes: C11orf30, LRRC32
mapped_gene: C11orf30 - LRRC32
upstream_gene_id: 56946
downstream_gene_id: 2615
strongest_risk_snp: rs2155219
strongest_risk_allele: T
snps: rs2155219
snp_id_current: 2155219
context: Intergenic
pvalue_mlog: 7.397940008672037
ci_95: [1.11-1.24]
platform: Affymetrix & Illumina [2,217,510] (imputed)
cnv: N
study:
A genome-wide meta-analysis of genetic variants associated with allergic rhinitis and grass sensitization and their interaction with birth order.


dbdate: 2011-12-16
author: Crosslin DR
date: 2011-10-30
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22037903
trait: White blood cell count
region: 1q23.2
chrom: 1
reported_genes: DARC
mapped_gene: ACKR1
snp_gene_ids: 2532
strongest_risk_snp: rs12075
snps: rs12075
snp_id_current: 12075
context: missense
pvalue_mlog: 23.30102999566398
ci_95: [1.03-1.51] K/ul increase
platform: Illumina [532,566]
cnv: N
study:
Genetic variants associated with the white blood cell count in 13,923 subjects in the eMERGE Network.

initial_samplesize:
62 American Indian or Alaska Native ancestry individuals, 158 Asian ancestry individuals, 3,272 African American ancestry individuals, 114 other ancestry individuals, 23,244 European ancestry individuals, 996 unknown ancestry individuals


dbdate: 2011-11-24
author: Haiman CA
date: 2011-10-30
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22037553
trait: Breast cancer
replication_samplesize: 2,222 European ancestry cases, 16,363 European ancestry controls
region: 5p15.33
chrom: 5
reported_genes: TERT
mapped_gene: TERT
snp_gene_ids: 7015
strongest_risk_snp: rs10069690
snps: rs10069690
snp_id_current: 10069690
context: intron
pvalue_mlog: 10
ci_95: [1.13-1.25]
platform: Illumina [3,154,485] (imputed)
cnv: N
study:
A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer.

initial_samplesize:
1,004 African ancestry cases, 2,745 African ancestry controls,1,718 European ancestry cases, 3,670 European ancestry controls


dbdate: 2011-12-02
author: Shi Y
date: 2011-10-30
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22037551
trait: Gastric cancer
initial_samplesize: 1,006 Chinese ancestry cases, 2,273 Chinese ancestry controls
replication_samplesize: 3,288 Chinese ancestry cases, 3,609 Chinese ancestry controls
region: 3q13.31
chrom: 3
reported_genes: ZBTB20
mapped_gene: ZBTB20;LOC102723469
snp_gene_ids: 26137;102723469
strongest_risk_snp: rs9841504
snps: rs9841504
snp_id_current: 9841504
context: intron;intron
pvalue_mlog: 8.698970004336019
ci_95: [1.20-1.45]
platform: Affymetrix [555,896]
cnv: N
study:
A genome-wide association study identifies new susceptibility loci for non-cardia gastric cancer at 3q13.31 and 5p13.1.


dbdate: 2011-12-02
author: Yue WH
date: 2011-10-30
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22037552
trait: Schizophrenia
initial_samplesize: 746 Chinese ancestry cases, 1,599 Chinese ancestry controls
replication_samplesize: 4,027 Chinese ancestry cases, 5,603 Chinese ancestry controls
region: 6p22.1
chrom: 6
reported_genes: NKAPL
mapped_gene: NKAPL;ZKSCAN4
snp_gene_ids: 222698;387032
strongest_risk_snp: rs1635
snps: rs1635
snp_id_current: 1635
context: missense;nearGene-5
pvalue_mlog: 11.15490195998574
ci_95: [1.22-1.37]
platform: Illumina [493,203]
cnv: N
study:
Genome-wide association study identifies a susceptibility locus for schizophrenia in Han Chinese at 11p11.2.


dbdate: 2011-12-13
author: Brockschmidt FF
date: 2011-10-27
journal: Br J Dermatol
link: http://www.ncbi.nlm.nih.gov/pubmed/22032556
trait: Male-pattern baldness
initial_samplesize: 581 European ancestry male cases, 617 European ancestry male controls
replication_samplesize: 461 European ancestry male cases, 151 European ancestry male controls
region: 20p11.22
chrom: 20
reported_genes: Intergenic
mapped_gene: RPL41P1 - LINC00261
upstream_gene_id: 22971
downstream_gene_id: 140828
strongest_risk_snp: rs2180439
snps: rs2180439
snp_id_current: 2180439
context: Intergenic
pvalue_mlog: 16.39794000867203
ci_95: [1.76-2.47]
platform: Illumina [560,387]
cnv: N
study:
Susceptibility variants on chromosome 7p21.1 suggest HDAC9 as a new candidate gene for male-pattern baldness.


dbdate: 2011-11-24
author: Takahashi Y
date: 2011-10-23
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22019779
trait: Scoliosis
initial_samplesize: 1,033 Japanese ancestry adolescent female cases, 1,473 Japanese ancestry female controls
replication_samplesize: 326 Japanese ancestry adolescent female cases, 9,823 Japanese ancestry female controls
region: 10q24.31
chrom: 10
reported_genes: LBX1
mapped_gene: RNY5P7 - LBX1
upstream_gene_id: 100169835
downstream_gene_id: 10660
strongest_risk_snp: rs11190870
snps: rs11190870
snp_id_current: 11190870
context: Intergenic
pvalue_mlog: 19
ci_95: [1.41-1.71]
platform: Illumina [455,121]
cnv: N
study:
A genome-wide association study identifies common variants near LBX1 associated with adolescent idiopathic scoliosis.


dbdate: 2011-11-25
author: Carty CL
date: 2011-10-21
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22021425
trait: Height
initial_samplesize: 8,149 African American ancestry women
replication_samplesize: Up to 20,809 African American ancestry and African ancestry individuals
region: 17q22
chrom: 17
reported_genes: TMEM100, PCTP
mapped_gene: MMD - TMEM100
upstream_gene_id: 23531
downstream_gene_id: 55273
strongest_risk_snp: rs1549519
strongest_risk_allele: T
snps: rs1549519
snp_id_current: 1549519
context: Intergenic
pvalue_mlog: 8.221848749616356
ci_95: [0.024-0.072] unit decrease
platform: Affymetrix [855,034]
cnv: N
study:
Genome-wide association study of body height in African Americans: the Women's Health Initiative SNP Health Association Resource (SHARe).


dbdate: 2011-11-24
author: Won HH
date: 2011-10-21
journal: Cancer
link: http://www.ncbi.nlm.nih.gov/pubmed/22020760
trait: Response to platinum-based agents
initial_samplesize: 96 colon cancer cases
replication_samplesize: 247 colon cancer cases
region: 7q21.3
chrom: 7
reported_genes: TAC1
mapped_gene: RPL7AP40 - TAC1
upstream_gene_id: 442712
downstream_gene_id: 6863
strongest_risk_snp: rs10486003
snps: rs10486003
snp_id_current: 10486003
context: Intergenic
pvalue_mlog: 6.30102999566398
ci_95: [1.92-5.26]
platform: Affymetrix [656,843]
cnv: N
study:
Polymorphic markers associated with severe oxaliplatin-induced, chronic peripheral neuropathy in colon cancer patients.


dbdate: 2011-11-30
author: Surakka I
date: 2011-10-20
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22028671
trait: Lipid traits
initial_samplesize: Up to 32,225 European ancestry individuals
replication_samplesize: 22,702 European ancestry individuals
region: 4p15.1
chrom: 4
reported_genes: PCDH7
mapped_gene: PCDH7 - MAPRE1P2
upstream_gene_id: 5099
downstream_gene_id: 642305
strongest_risk_snp: rs6448771
snps: rs6448771
snp_id_current: 6448771
context: Intergenic
pvalue_mlog: 8.301029995663981
ci_95: [-0.00728-0.06328] unit increase
platform: Affymetrix, Illumina & Perlegen [~2.5 million] (imputed)
cnv: N
study:
A genome-wide screen for interactions reveals a new locus on 4p15 modifying the effect of waist-to-hip ratio on total cholesterol.


dbdate: 2011-11-30
author: Hinney A
date: 2011-10-19
journal: Am J Med Genet B Neuropsychiatr Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22012869
study: Genome-wide association study in German patients with attention deficit/hyperactivity disorder.
trait: Attention deficit hyperactivity disorder
initial_samplesize: 495 European ancestry child and adolescent cases, 1,300 European ancestry adult controls
region: 2p16.1
chrom: 2
reported_genes: BCL11A
mapped_gene: BCL11A
snp_gene_ids: 53335
strongest_risk_snp: rs2556378
strongest_risk_allele: T
snps: rs2556378
snp_id_current: 2556378
context: intron
pvalue_mlog: 5.154901959985742
platform: Illumina [487,484]
cnv: N
replication_samplesize:
1023 individuals (from 320 families with at least one affected child), 896 controls and 2455 cases (from 2064 trios)


dbdate: 2011-11-18
author: Frank J
date: 2011-10-18
journal: Addict Biol
link: http://www.ncbi.nlm.nih.gov/pubmed/22004471
trait: Alcohol dependence
initial_samplesize: 1,333 European ancestry cases, 2,168 European ancestry controls
region: 2q35
chrom: 2
mapped_gene: MREG - PECR
upstream_gene_id: 55686
downstream_gene_id: 55825
strongest_risk_snp: rs1344694
snps: rs1344694
snp_id_current: 1344694
context: Intergenic
pvalue_mlog: 5.301029995663981
ci_95: [1.15-1.41]
platform: Illumina [463,044]
cnv: N
study:
Genome-wide significant association between alcohol dependence and a variant in the ADH gene cluster.


dbdate: 2011-11-19
author: Hollingworth P
date: 2011-10-18
journal: Mol Psychiatry
link: http://www.ncbi.nlm.nih.gov/pubmed/22005930
study: Genome-wide association study of Alzheimer's disease with psychotic symptoms.
trait: Alzheimer's disease
region: 10q22.1
chrom: 10
reported_genes: RP11-242G20.2
mapped_gene: C10orf35 - RPL5P26
upstream_gene_id: 219738
downstream_gene_id: 100271206
strongest_risk_snp: rs4746003
snps: rs4746003
snp_id_current: 4746003
context: Intergenic
pvalue_mlog: 5.221848749616356
ci_95: [NR]
platform: Illumina [>1.8 million] (imputed)
cnv: N
initial_samplesize:
1,299 European ancestry, African American ancestry and Native American ancestry cases with psychosis, 735 European ancestry, African American ancestry and Native American ancestry cases without psychosis, 5,659 European ancestry, African American ancestry and Native American ancestry controls


dbdate: 2011-11-09
author: Wu X
date: 2011-10-18
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22010048
trait: Renal cell carcinoma
initial_samplesize: 894 European ancestry cases, 1,516 European ancestry controls
replication_samplesize: 3,772 European ancestry cases, 8,505 European ancestry controls
region: 12p12.1
chrom: 12
reported_genes: ITPR2
mapped_gene: SSPN - ITPR2
upstream_gene_id: 8082
downstream_gene_id: 3709
strongest_risk_snp: rs718314
snps: rs718314
snp_id_current: 718314
context: Intergenic
pvalue_mlog: 9.045757490560675
ci_95: [1.13-1.26]
platform: Illumina [533,191]
cnv: N
study:
A genome-wide association study identifies a novel susceptibility locus for renal cell carcinoma on 12p11.23.


dbdate: 2011-11-15
author: Yoon D
date: 2011-10-18
journal: Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22006218
trait: Smoking behavior
initial_samplesize: 8,842 Korean ancestry individuals
replication_samplesize: 1,366 African American ancestry individuals, 671 European ancestry individuals
region: 5q33.2
chrom: 5
reported_genes: Intergenic
mapped_gene: PPIGP1 - SGCD
upstream_gene_id: 100131033
downstream_gene_id: 6444
strongest_risk_snp: rs11134474
snps: rs11134474
snp_id_current: 11134474
context: Intergenic
pvalue_mlog: 5.096910013008055
platform: Affymetrix [352,228]
cnv: N
study:
Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence.


dbdate: 2011-11-18
author: Chambers JC
date: 2011-10-16
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22001757
trait: Liver enzyme levels (alanine transaminase)
initial_samplesize: Up to 52,350 European ancestry individuals, up to 8,739 Indian Asian individuals
region: 4q22.1
chrom: 4
reported_genes: HSD17B13, MAPK10
mapped_gene: GAPDHP60 - MIR5705
upstream_gene_id: 2601
downstream_gene_id: 100847027
strongest_risk_snp: rs6834314
strongest_risk_allele: A
snps: rs6834314
snp_id_current: 6834314
context: Intergenic
pvalue_mlog: 8.522878745280337
ci_95: [1.90-3.40] % increase
platform: Affymetrix, Illumina, and Perlegen [~2.6 million] (imputed)
cnv: N
study:
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma.


dbdate: 2011-11-09
author: Khor CC
date: 2011-10-16
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/22001756
trait: Dengue shock syndrome
initial_samplesize: 2,008 Vietnamese ancestry cases, 2,018 Vietnamese ancestry controls
replication_samplesize: 1,737 Vietnamese ancestry cases, 2,934 Vietnamese ancestry controls
region: 6p21.33
chrom: 6
reported_genes: MICB
mapped_gene: MICB
snp_gene_ids: 4277
strongest_risk_snp: rs3132468
snps: rs3132468
snp_id_current: 3132468
context: intron
pvalue_mlog: 10.39794000867204
ci_95: [1.23-1.46]
platform: Illumina [481,342]
cnv: N
study:
Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.


dbdate: 2011-11-16
author: Grallert H
date: 2011-10-14
journal: Eur Heart J
link: http://www.ncbi.nlm.nih.gov/pubmed/22003152
trait: Lipoprotein-associated phospholipase A2 activity and mass
initial_samplesize: 12,126 European ancestry individuals, 1,538 Other ancestry individuals
region: 19q13.32
chrom: 19
reported_genes: APOC1
mapped_gene: APOC1
snp_gene_ids: 341
strongest_risk_snp: rs4420638
strongest_risk_allele: A
snps: rs4420638
snp_id_current: 4420638
context: nearGene-3
pvalue_mlog: 29.30102999566398
ci_95: [0.044-0.064] unit decrease
platform: Affymetrix & Illumina [2,661,766] (imputed)
cnv: N
study:
Eight genetic loci associated with variation in lipoprotein-associated phospholipase A2 mass and activity and coronary heart disease: meta-analysis of genome-wide association studies from five community-based studies.


dbdate: 2011-11-18
author: Kuparinen T
date: 2011-10-13
journal: Genes Immun
link: http://www.ncbi.nlm.nih.gov/pubmed/21993531
trait: Cytomegalovirus antibody response
initial_samplesize: 1,485 European ancestry sero-postitive individuals, 648 European ancestry sero-negative individuals
region: 7p14.3
chrom: 7
reported_genes: Intergenic
mapped_gene: RNA5SP229 - FLJ20712
upstream_gene_id: 100873487
downstream_gene_id: 55025
strongest_risk_snp: rs17170316
strongest_risk_allele: A
snps: rs17170316
snp_id_current: 17170316
context: Intergenic
pvalue_mlog: 6.096910013008056
ci_95: [0.20-0.45] unit decrease
platform: Illumina [546,677]
cnv: N
study:
Genome-wide association study does not reveal major genetic determinants for anti-cytomegalovirus antibody response.


dbdate: 2011-11-04
author: Drago A
date: 2011-10-11
journal: Am J Med Genet B Neuropsychiatr Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21990027
trait: Response to antipsychotic therapy (extrapyramidal side effects)
initial_samplesize: 409 European or other ancestry bipolar cases
region: 4p15.33
chrom: 4
mapped_gene: LINC01182
snp_gene_ids: 101929071
strongest_risk_snp: rs10805321
snps: rs10805321
snp_id_current: 10805321
context: intron
pvalue_mlog: 5.045757490560675
ci_95: [NR] unit increase
platform: Affymetrix [NR]
cnv: N
study:
The genetics of antipsychotic induced tremors: a genome-wide pathway analysis on the STEP-BD SCP sample.


dbdate: 2011-12-10
author: Denny JC
date: 2011-10-07
journal: Am J Hum Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21981779
trait: Hypothyroidism
initial_samplesize: 1,317 European ancestry cases, 5,053 European ancestry controls
replication_samplesize: 263 European ancestry cases, 1,616 European ancestry controls
region: 9q22.33
chrom: 9
reported_genes: FOXE1
mapped_gene: KRT18P13 - FOXE1
upstream_gene_id: 392371
downstream_gene_id: 2304
strongest_risk_snp: rs7850258
snps: rs7850258
snp_id_current: 7850258
context: Intergenic
pvalue_mlog: 8.397940008672036
ci_95: [1.04-1.47]
platform: Illumina [522,164]
cnv: N
study:
Variants near FOXE1 are associated with hypothyroidism and other thyroid conditions: using electronic medical records for genome- and phenome-wide studies.


dbdate: 2011-11-04
author: Li X
date: 2011-10-06
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21979947
trait: Corneal structure
initial_samplesize: 222 European ancestry cases, 3,324 European ancestry controls
region: 2q21.3
chrom: 2
reported_genes: RAB3GAP1
mapped_gene: MAP3K19 - RAB3GAP1
upstream_gene_id: 80122
downstream_gene_id: 22930
strongest_risk_snp: rs4954218
snps: rs4954218
snp_id_current: 4954218
context: Intergenic
pvalue_mlog: 8.999999999999998
platform: Illumina [~290,000]
cnv: N
study:
A genome-wide association study identifies a potential novel gene locus for keratoconus, one of the commonest causes for corneal transplantation in developed countries.

replication_samplesize:
304 European ancestry cases, 518 European ancestry controls, 146 European ancestry cases and 161 European ancestry controls from 70 families


dbdate: 2011-11-08
author: N'Diaye A
date: 2011-10-06
journal: PLoS Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21998595
trait: Height
initial_samplesize: 20,427 African ancestry individuals
replication_samplesize: Up to 16,436 African American individuals
region: 2q35
chrom: 2
reported_genes: Intergenic
mapped_gene: TNP1 - DIRC3
upstream_gene_id: 7141
downstream_gene_id: 729582
strongest_risk_snp: rs2553026
strongest_risk_allele: A
snps: rs2553026
snp_id_current: 2553026
context: Intergenic
pvalue_mlog: 7.221848749616355
ci_95: [0.036-0.076] unit increase
platform: Affymetrix & Illumina [3,310,998] (imputed)
cnv: N
study:
Identification, replication, and fine-mapping of Loci associated with adult height in individuals of african ancestry.


dbdate: 2011-11-04
author: Liu L
date: 2011-10-01
journal: Viral Immunol
link: http://www.ncbi.nlm.nih.gov/pubmed/22004137
trait: Hepatitis B
initial_samplesize: 1,944 Han Chinese ancestry progressed cases, 854 Han Chinese ancestry asymptomatic carriers
region: 16p13.2
chrom: 16
reported_genes: GRIN2A
mapped_gene: GRIN2A
snp_gene_ids: 2903
strongest_risk_snp: rs11866328
strongest_risk_allele: G
snps: rs11866328
snp_id_current: 11866328
context: intron
pvalue_mlog: 7.698970004336018
ci_95: [1.40-2.02]
platform: Affymetrix [NR] (pooled)
cnv: N
study:
A genome-wide association study with DNA pooling identifies the variant rs11866328 in the GRIN2A gene that affects disease progression of chronic HBV infection.


dbdate: 2011-10-22
author: Zuo L
date: 2011-09-28
journal: Neuropsychopharmacology
link: http://www.ncbi.nlm.nih.gov/pubmed/21956439
study: Genome-wide association study of alcohol dependence implicates KIAA0040 on chromosome 1q.
trait: Alcohol dependence
region: 3p25.1
chrom: 3
reported_genes: SH3BP5
mapped_gene: SH3BP5;SH3BP5-AS1
snp_gene_ids: 9467;100505696
strongest_risk_snp: rs1318937
snps: rs1318937
snp_id_current: 1318937
context: nearGene-3;nearGene-5
pvalue_mlog: 5.522878745280337
platform: Illumina [805,814]
cnv: N
initial_samplesize:
1,409 European ancestry cases, 1,518 European ancestry controls, 681 African American cases, 508 African American controls


dbdate: 2011-10-20
author: Middelberg RP
date: 2011-09-24
journal: BMC Med Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21943158
trait: Cardiovascular disease risk factors
initial_samplesize: 11,683 European ancestry individuals
region: 1p13.3
chrom: 1
reported_genes: CELSR2
mapped_gene: CELSR2
snp_gene_ids: 1952
strongest_risk_snp: rs660240
strongest_risk_allele: T
snps: rs660240
snp_id_current: 660240
context: UTR-3
pvalue_mlog: 21.69897000433602
ci_95: [0.14-0.20] mmol/l decrease
platform: Illumina [NR] (imputed)
cnv: N
study:
Genetic variants in LPL, OASL and TOMM40/APOE-C1-C2-C4 genes are associated with multiple cardiovascular-related traits.


dbdate: 2011-10-07
author: Amos CI
date: 2011-09-22
journal: Hum Mol Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21926416
study: Genome-wide association study identifies novel loci predisposing to cutaneous melanoma.
trait: Melanoma
initial_samplesize: 1,804 European ancestry cases, 1,026 European ancestry controls
region: 1q21.3
chrom: 1
reported_genes: ANXA9
mapped_gene: ANXA9
snp_gene_ids: 8416
strongest_risk_snp: rs1722784
snps: rs1722784
snp_id_current: 1722784
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [NR]
platform: Illumina [818,977]
cnv: N
replication_samplesize:
6,483 European and Middle East/North African ancestry cases, 23,324 European and Middle East/North African ancestry controls


dbdate: 2011-10-19
author: Sklar P
date: 2011-09-18
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21926972
trait: Bipolar disorder
initial_samplesize: 7,481 European ancestry cases, 9,250 European ancestry controls
replication_samplesize: 4,496 European ancestry cases, 42,422 European ancestry controls
region: 12p13.33
chrom: 12
reported_genes: CANCNA1C
mapped_gene: CACNA1C
snp_gene_ids: 775
strongest_risk_snp: rs4765913
strongest_risk_allele: A
snps: rs4765913
snp_id_current: 4765913
context: intron
pvalue_mlog: 7.698970004336018
ci_95: [NR]
platform: Affymetrix & Illumina [2,415,422] (imputed)
cnv: N
study:
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.


dbdate: 2011-10-19
author: Sklar P
date: 2011-09-18
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21926972
trait: Bipolar disorder
initial_samplesize: 7,481 European ancestry cases, 9,250 European ancestry controls
replication_samplesize: 4,496 European ancestry cases, 42,422 European ancestry controls
region: 11q13.2
chrom: 11
mapped_gene: C11orf80
snp_gene_ids: 79703
strongest_risk_snp: rs10896135
strongest_risk_allele: G
snps: rs10896135
snp_id_current: 10896135
context: intron
pvalue_mlog: 6.698970004336019
ci_95: [NR]
platform: Affymetrix & Illumina [2,415,422] (imputed)
cnv: N
study:
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.

reported_genes:
ZDHHC24, YIF1A, TMEM151A, SYT12, SPTBN2,SLC29A2, SF3B2, RIN1, RCE1, RBM4B, RBM4, RBM14, RAB1B, PELI3, PC, PACS1, NPAS4, MRPL11, LRFN4, KLC2, GAL3ST3, DPP3, CTSF, CNIH2, CD248, CCS, CCDC87, C11orf86, C11orf80, BRMS1, BBS1, B3GNT1, ACTN3


dbdate: 2011-10-19
author: Sklar P
date: 2011-09-18
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21926972
trait: Bipolar disorder
initial_samplesize: 7,481 European ancestry cases, 9,250 European ancestry controls
replication_samplesize: 4,496 European ancestry cases, 42,422 European ancestry controls
region: 3p21.1
chrom: 3
mapped_gene: ITIH3
snp_gene_ids: 3699
strongest_risk_snp: rs736408
strongest_risk_allele: C
snps: rs736408
snp_id_current: 736408
context: intron
pvalue_mlog: 5.698970004336018
ci_95: [NR]
platform: Affymetrix & Illumina [2,415,422] (imputed)
cnv: N
reported_genes:
WDR82, TWF2, TNNC1, TMEM110, TLR9, STAB1,SPCS1, SNORD69, SNORD19, SNORD19B, SFMBT1, SEMA3G, RFT1, PRKCD, PPM1M, PHF7, PBRM1, NT5DC2, NISCH, NEK4, MUSTN1, LOC440957, ITIH1, ITIH3, ITIH4, GNL3, GLYCTK, GLT8D1, DNAH1, BAP1, ALAS1


dbdate: 2011-10-06
author: Paternoster L
date: 2011-09-15
journal: PLoS One
link: http://www.ncbi.nlm.nih.gov/pubmed/21935397
trait: Obesity (extreme)
initial_samplesize: 2,633 European ancestry extremely obese adults, 2,740 European ancestry controls
replication_samplesize: 29,181 European ancestry individuals
region: 6p12.3
chrom: 6
reported_genes: TFAP2B
mapped_gene: TRNAI25
snp_gene_ids: 100189401
strongest_risk_snp: rs734597
strongest_risk_allele: A
snps: rs734597
snp_id_current: 734597
pvalue_mlog: 7.522878745280337
platform: Illumina [545,349]
cnv: N
study:
Genome-wide population-based association study of extremely overweight young adults--the GOYA study.


dbdate: 2011-10-07
author: Tohkin M
date: 2011-09-13
journal: Pharmacogenomics J
link: http://www.ncbi.nlm.nih.gov/pubmed/21912425
trait: Stevens-Johnson syndrome and toxic epidermal necrolysis (SJS-TEN)
initial_samplesize: 14 Japanese ancestry cases, 991 Japanese ancestry controls
region: 6p21.33
chrom: 6
mapped_gene: DDX39B;SNORD117;ATP6V1G2-DDX39B
snp_gene_ids: 7919;692233;100532737
strongest_risk_snp: rs2734583
snps: rs2734583
snp_id_current: 2734583
context: intron;nearGene-5;intron
pvalue_mlog: 7.698970004336018
ci_95: [19.8-225.0]
platform: Illumina [890,321]
cnv: N
study:
A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients.

reported_genes:
BAT1, HCP5, MICC, PPIAP9, PSORS1C1, POLR2LP, CCHCR1, TCF19, POU5F1, HLA-C, HCP5, PSORS1C3, HLA-B*5801


dbdate: 2011-10-05
author: Arakawa S
date: 2011-09-11
journal: Nat Genet
link: http://www.ncbi.nlm.nih.gov/pubmed/21909106
trait: Age-related macular degeneration
initial_samplesize: 827 Japanese ancestry cases, 3,323 Japanese ancestry controls
replication_samplesize: 709 Japanese ancestry cases, 15,571 Japanese ancestry controls
region: 8p21.3
chrom: 8
reported_genes: TNFRSF10A, LOC389641
mapped_gene: TNFRSF10A;LOC389641
snp_gene_ids: 8797;389641
strongest_risk_snp: rs13278062
strongest_risk_allele: T
snps: rs13278062
snp_id_current: 13278062
context: nearGene-5;ncRNA
pvalue_mlog: 12
ci_95: [1.25-1.49]
platform: Illumina [457,489]
cnv: N
study:
Genome-wide association study identifies two susceptibility loci for exudative age-related macular degeneration in the Japanese population.


