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Analysis Details for My Projects->Mac - Oyster RNA-Seq->20220810_NOPP-gigas-ploidy-temp_pval_only 10:49 AM->desiccation_ploidy Workspace My Projects Project Mac - Oyster RNA-Seq Analysis desiccation_ploidy Date Wed Aug 10 10:51:14 PDT 2022 Analysis ID 39750471 Analysis Settings Cutoff before duplicate resolution true Resolve duplicate on Expression pvalue Color using Expression logfoldchange Cutoff for Expression pvalue 0.05 Cutoff for Expression logfoldchange -- Reference set Ingenuity Knowledge Base (Genes Only) Relationship to include Direct and Indirect Includes Endogenous Chemicals Yes Optional Analyses My Pathways My List Filter Summary Consider only molecules and/or relationships where (confidence = Experimentally Observed) AND (mol. types = biologic drug OR canonical pathway OR chemical - endogenous mammalian OR chemical - endogenous non-mammalian OR chemical - kinase inhibitor OR chemical - other OR chemical - protease inhibitor OR chemical drug OR chemical reagent OR chemical toxicant OR complex OR cytokine OR disease OR enzyme OR function OR fusion gene/product OR G-protein coupled receptor OR group OR growth factor OR ion channel OR kinase OR ligand-dependent nuclear receptor OR mature microRNA OR microRNA OR other OR peptidase OR phosphatase OR transcription regulator OR translation regulator OR transmembrane receptor OR transporter) Canonical Pathways for My Projects->Mac - Oyster RNA-Seq->20220810_NOPP-gigas-ploidy-temp_pval_only 10:49 AM->desiccation_ploidy Ingenuity Canonical Pathways -log(p-value) zScore Ratio Molecules 3-phosphoinositide Biosynthesis -0E00 4.78E-03 PPP1CA 3-phosphoinositide Degradation -0E00 5.13E-03 PPP1CA Actin Cytoskeleton Signaling -0E00 4.10E-03 ITGB3 Acute Phase Response Signaling -0E00 5.41E-03 PLG Adipogenesis pathway -0E00 7.41E-03 CEBPD Aldosterone Signaling in Epithelial Cells -0E00 5.95E-03 HSPA12B Atherosclerosis Signaling -0E00 7.63E-03 TNFSF14 Autophagy -0E00 4.63E-03 CALM1 (includes others) B Cell Receptor Signaling -0E00 1.57E-03 CALM1 (includes others) CCR5 Signaling in Macrophages -0E00 4.01E-03 CALM1 (includes others),GNAO1 CD28 Signaling in T Helper Cells -0E00 1.93E-03 CALM1 (includes others) CDC42 Signaling -0E00 1.73E-03 ITGB3 CDX Gastrointestinal Cancer Signaling Pathway -0E00 4.95E-03 TNFSF14 CLEAR Signaling Pathway -0E00 7.02E-03 GLB1,MAPK4 CXCR4 Signaling -0E00 5.95E-03 GNAO1 Calcium-induced T Lymphocyte Apoptosis -0E00 2.17E-03 CALM1 (includes others) Cardiac Hypertrophy Signaling -0E00 7.66E-03 CALM1 (includes others),GNAO1 Cardiac Hypertrophy Signaling (Enhanced) -0E00 5.54E-03 CALM1 (includes others),ITGB3,TNFSF14 Cellular Effects of Sildenafil (Viagra) -0E00 6.67E-03 CALM1 (includes others) D-myo-inositol (1,4,5,6)-Tetrakisphosphate Biosynthesis -0E00 5.46E-03 PPP1CA D-myo-inositol (3,4,5,6)-tetrakisphosphate Biosynthesis -0E00 5.46E-03 PPP1CA D-myo-inositol-5-phosphate Metabolism -0E00 5.03E-03 PPP1CA EIF2 Signaling -0E00 4.41E-03 PPP1CA Epithelial Adherens Junction Signaling -0E00 6.37E-03 NANOS1 Estrogen Receptor Signaling -0E00 2.44E-03 GNAO1 FAK Signaling -0E00 -0.3779644730092272 6.72E-03 ADGRG6,CALCRL,CELSR1,HCRTR2,ITGB3,MAPK4,PTGIR G Beta Gamma Signaling -0E00 7.75E-03 GNAO1 GABA Receptor Signaling -0E00 7.58E-03 GNAO1 GNRH Signaling -0E00 5.24E-03 CALM1 (includes others) Glucocorticoid Receptor Signaling -0E00 3.43E-03 KRT8,TSG101 Gustation Pathway -0E00 4.93E-03 PNLIP Gαi Signaling -0E00 7.14E-03 GNAO1 HER-2 Signaling in Breast Cancer -0E00 4.41E-03 ITGB3 HGF Signaling -0E00 7.58E-03 ITGB3 HMGB1 Signaling -0E00 5.99E-03 TNFSF14 Hepatic Cholestasis -0E00 5.24E-03 TNFSF14 Human Embryonic Stem Cell Pluripotency -0E00 6.02E-03 GNAO1 Huntington's Disease Signaling -0E00 7.07E-03 CASP2,SNAP25 ICOS-ICOSL Signaling in T Helper Cells -0E00 1.97E-03 CALM1 (includes others) Insulin Receptor Signaling -0E00 7.14E-03 PPP1CA Insulin Secretion Signaling Pathway -0E00 3.68E-03 SNAP25 Integrin Signaling -0E00 4.72E-03 ITGB3 Macrophage Classical Activation Signaling Pathway -0E00 5.29E-03 TNFSF14 Multiple Sclerosis Signaling Pathway -0E00 4.50E-03 TNFSF14 NAD Signaling Pathway -0E00 6.62E-03 TRPM2 NUR77 Signaling in T Lymphocytes -0E00 1.95E-03 CALM1 (includes others) P2Y Purigenic Receptor Signaling Pathway -0E00 7.52E-03 ITGB3 PI3K Signaling in B Lymphocytes -0E00 6.90E-03 CALM1 (includes others) PI3K/AKT Signaling -0E00 5.00E-03 ITGB3 PTEN Signaling -0E00 6.67E-03 ITGB3 Phospholipase C Signaling -0E00 2.93E-03 CALM1 (includes others),ITGB3 Production of Nitric Oxide and Reactive Oxygen Species in Macrophages -0E00 5.24E-03 PPP1CA Pulmonary Fibrosis Idiopathic Signaling Pathway -0E00 3.07E-03 PLG Regulation Of The Epithelial Mesenchymal Transition By Growth Factors Pathway -0E00 5.21E-03 TNFSF14 Regulation of IL-2 Expression in Activated and Anergic T Lymphocytes -0E00 2.16E-03 CALM1 (includes others) Regulation of eIF4 and p70S6K Signaling -0E00 5.52E-03 ITGB3 Relaxin Signaling -0E00 6.45E-03 GNAO1 Ribonucleotide Reductase Signaling Pathway -0E00 5.88E-03 RRM2 Role Of Chondrocytes In Rheumatoid Arthritis Signaling Pathway -0E00 7.09E-03 CEBPD Role of NFAT in Cardiac Hypertrophy -0E00 4.50E-03 CALM1 (includes others) Role of NFAT in Regulation of the Immune Response -0E00 3.38E-03 CALM1 (includes others),GNAO1 Role of Pattern Recognition Receptors in Recognition of Bacteria and Viruses -0E00 6.41E-03 TNFSF14 Sertoli Cell-Sertoli Cell Junction Signaling -0E00 4.85E-03 ITGB3 Signaling by Rho Family GTPases -0E00 7.49E-03 GNAO1,ITGB3 Superpathway of Inositol Phosphate Compounds -0E00 4.20E-03 PPP1CA Synaptic Long Term Depression -0E00 5.10E-03 GNAO1 Systemic Lupus Erythematosus In B Cell Signaling Pathway -0E00 2.76E-03 CALM1 (includes others),TNFSF14 Systemic Lupus Erythematosus In T Cell Signaling Pathway -0E00 1.55E-03 CASP2 T Cell Receptor Signaling -0E00 1.62E-03 CALM1 (includes others) TEC Kinase Signaling -0E00 3.46E-03 GNAO1,ITGB3 Thrombin Signaling -0E00 4.44E-03 GNAO1 Tight Junction Signaling -0E00 5.59E-03 SNAP25 Tumor Microenvironment Pathway -0E00 5.59E-03 ITGB3 White Adipose Tissue Browning Pathway -0E00 7.25E-03 ANGPT2 Wound Healing Signaling Pathway -0E00 3.97E-03 TNFSF14 Xenobiotic Metabolism General Signaling Pathway -0E00 6.99E-03 GSTM3 FXR/RXR Activation 2.03E-01 7.94E-03 FASN Glioma Signaling 2.07E-01 8.06E-03 CALM1 (includes others) IL-15 Production 2.09E-01 8.13E-03 PTK7 LXR/RXR Activation 2.09E-01 8.13E-03 FASN Neuroprotective Role of THOP1 in Alzheimer's Disease 2.13E-01 8.26E-03 PLG Nitric Oxide Signaling in the Cardiovascular System 2.15E-01 8.33E-03 CALM1 (includes others) Sphingosine-1-phosphate Signaling 2.15E-01 8.33E-03 CASP2 Airway Pathology in Chronic Obstructive Pulmonary Disease 2.2E-01 8.47E-03 TNFSF14 Neuregulin Signaling 2.22E-01 8.55E-03 ITGB3 PAK Signaling 2.22E-01 8.55E-03 ITGB3 Role of Tissue Factor in Cancer 2.24E-01 8.62E-03 ITGB3 Regulation of Actin-based Motility by Rho 2.27E-01 8.70E-03 ITGB3 Paxillin Signaling 2.46E-01 9.35E-03 ITGB3 Axonal Guidance Signaling 2.51E-01 7.86E-03 ADAMTS16,GNAO1,ITGB3,L1CAM Pathogen Induced Cytokine Storm Signaling Pathway 2.56E-01 8.06E-03 CGAS,MAPK4,TNFSF14 Apelin Cardiomyocyte Signaling Pathway 2.68E-01 1.01E-02 MAPK4 IL-1 Signaling 2.77E-01 1.04E-02 GNAO1 Small Cell Lung Cancer Signaling 2.77E-01 1.04E-02 BIRC2 Neurovascular Coupling Signaling Pathway 2.79E-01 8.85E-03 CALM1 (includes others),PTGIR Fcγ Receptor-mediated Phagocytosis in Macrophages and Monocytes 2.83E-01 1.06E-02 RAB11A Actin Nucleation by ARP-WASP Complex 2.87E-01 1.08E-02 ITGB3 RHOGDI Signaling 2.91E-01 9.09E-03 GNAO1,ITGB3 Apelin Adipocyte Signaling Pathway 2.93E-01 1.10E-02 MAPK4 Crosstalk between Dendritic Cells and Natural Killer Cells 2.93E-01 1.10E-02 CD209 Immunogenic Cell Death Signaling Pathway 2.96E-01 1.11E-02 CGAS Unfolded protein response 2.96E-01 1.11E-02 CEBPD Regulation of Cellular Mechanics by Calpain Protease 3E-01 1.12E-02 ITGB3 ERK/MAPK Signaling 3.01E-01 9.30E-03 ITGB3,PPP1CA Heparan Sulfate Biosynthesis 3.03E-01 1.14E-02 SULT1A2 Heparan Sulfate Biosynthesis (Late Stages) 3.29E-01 1.23E-02 SULT1A2 Ephrin Receptor Signaling 3.3E-01 9.90E-03 GNAO1,ITGB3 Chemokine Signaling 3.32E-01 1.25E-02 CALM1 (includes others) Dopamine Receptor Signaling 3.32E-01 1.25E-02 PPP1CA ILK Signaling 3.33E-01 9.95E-03 FLNC,ITGB3 NF-κB Activation by Viruses 3.4E-01 1.28E-02 ITGB3 VDR/RXR Activation 3.4E-01 1.28E-02 LRP5 Oxytocin In Brain Signaling Pathway 3.43E-01 1.02E-02 CALM1 (includes others),GNAO1 PPARα/RXRα Activation 3.48E-01 1.03E-02 ACAA1,FASN Neuroinflammation Signaling Pathway 3.48E-01 9.46E-03 BIRC2,BIRC3,MAPK4 Angiopoietin Signaling 3.49E-01 1.32E-02 ANGPT2 Macropinocytosis Signaling 3.49E-01 1.32E-02 ITGB3 Ephrin B Signaling 3.66E-01 1.39E-02 GNAO1 IL-17 Signaling 3.68E-01 1.07E-02 TNFSF14,TRAF3IP2 Dopamine-DARPP32 Feedback in cAMP Signaling 3.74E-01 1.08E-02 CALM1 (includes others),PPP1CA Hepatic Fibrosis Signaling Pathway 3.78E-01 9.46E-03 CALM1 (includes others),ITGB3,LRP5,LRP6 Eicosanoid Signaling 3.85E-01 1.47E-02 PTGIR Cardiac β-adrenergic Signaling 3.88E-01 1.11E-02 GNAO1,PPP1CA IL-17A Signaling in Airway Cells 3.9E-01 1.49E-02 TRAF3IP2 Superpathway of Melatonin Degradation 3.9E-01 1.49E-02 SULT1A2 Glutamate Receptor Signaling 3.95E-01 1.52E-02 CALM1 (includes others) Melatonin Degradation I 4.15E-01 1.61E-02 SULT1A2 Gαq Signaling 4.18E-01 1.18E-02 CALM1 (includes others),GNAO1 Androgen Signaling 4.21E-01 1.18E-02 CALM1 (includes others),GNAO1 Oxytocin Signaling Pathway 4.25E-01 1.06E-02 CALM1 (includes others),GNAO1,MAPK4 Dermatan Sulfate Biosynthesis 4.27E-01 1.67E-02 SULT1A2 PCP (Planar Cell Polarity) Pathway 4.27E-01 1.67E-02 CELSR1 Opioid Signaling Pathway 4.32E-01 1.08E-02 CALM1 (includes others),GNAO1,MAPK4 Triacylglycerol Degradation 4.32E-01 1.69E-02 PNLIP Chondroitin Sulfate Biosynthesis 4.38E-01 1.72E-02 SULT1A2 Inhibition of ARE-Mediated mRNA Degradation Pathway 4.44E-01 1.23E-02 MAPK4,TNFSF14 Protein Ubiquitination Pathway 4.45E-01 1.09E-02 BIRC2,BIRC3,HSPA12B Colorectal Cancer Metastasis Signaling 4.52E-01 1.11E-02 GNAO1,LRP5,LRP6 Aryl Hydrocarbon Receptor Signaling 4.54E-01 1.26E-02 ALDH7A1,GSTM3 Phagosome Maturation 4.58E-01 1.27E-02 SNAP25,TSG101 Transcriptional Regulatory Network in Embryonic Stem Cells 4.63E-01 1.85E-02 L1CAM Necroptosis Signaling Pathway 4.65E-01 1.28E-02 BIRC2,BIRC3 Factors Promoting Cardiogenesis in Vertebrates 4.8E-01 1.32E-02 LRP5,LRP6 Corticotropin Releasing Hormone Signaling 4.83E-01 1.32E-02 CALM1 (includes others),GNAO1 Semaphorin Neuronal Repulsive Signaling Pathway 4.87E-01 1.33E-02 ITGB3,NCAN Chondroitin Sulfate Biosynthesis (Late Stages) 4.9E-01 2.00E-02 SULT1A2 MYC Mediated Apoptosis Signaling 4.9E-01 2.00E-02 CASP2 Endocannabinoid Neuronal Synapse Pathway 4.91E-01 1.34E-02 GNAO1,MAPK4 Sperm Motility 4.96E-01 1.18E-02 CALM1 (includes others),GNAO1,PTK7 Endocannabinoid Cancer Inhibition Pathway 4.99E-01 1.36E-02 CASP2,GNAO1 Apelin Muscle Signaling Pathway 5.05E-01 2.08E-02 GNAO1 nNOS Signaling in Skeletal Muscle Cells 5.05E-01 2.08E-02 CALM1 (includes others) Dermatan Sulfate Biosynthesis (Late Stages) 5.12E-01 2.13E-02 SULT1A2 Retinol Biosynthesis 5.12E-01 2.13E-02 PNLIP Role of IL-17F in Allergic Inflammatory Airway Diseases 5.12E-01 2.13E-02 TRAF3IP2 iNOS Signaling 5.12E-01 2.13E-02 CALM1 (includes others) nNOS Signaling in Neurons 5.12E-01 2.13E-02 CALM1 (includes others) Apelin Endothelial Signaling Pathway 5.23E-01 1.42E-02 CALM1 (includes others),GNAO1 Iron homeostasis signaling pathway 5.35E-01 1.45E-02 NUBP1,TMPRSS6 G Protein Signaling Mediated by Tubby 5.36E-01 2.27E-02 GNAO1 RAC Signaling 5.4E-01 1.46E-02 ANK1,ITGB3 Role Of Osteoblasts In Rheumatoid Arthritis Signaling Pathway 5.42E-01 1.25E-02 LRP5,LRP6,TNFSF14 NRF2-mediated Oxidative Stress Response 5.52E-01 1.27E-02 Cyp2d22,GSTM3,SOD3 CCR3 Signaling in Eosinophils 5.53E-01 1.49E-02 CALM1 (includes others),GNAO1 Osteoarthritis Pathway 5.55E-01 1.27E-02 C1QTNF4,CASP2,ITGB3 cAMP-mediated signaling 5.58E-01 1.28E-02 CALM1 (includes others),GNAO1,PTGIR Ferroptosis Signaling Pathway 5.62E-01 1.52E-02 CHAC1,H2AC21 Synaptic Long Term Potentiation 5.67E-01 1.53E-02 CALM1 (includes others),PPP1CA fMLP Signaling in Neutrophils 5.67E-01 1.53E-02 CALM1 (includes others),GNAO1 Thyroid Hormone Metabolism II (via Conjugation and/or Degradation) 5.71E-01 2.50E-02 SULT1A2 Endocannabinoid Developing Neuron Pathway 5.85E-01 1.57E-02 GNAO1,MAPK4 GP6 Signaling Pathway 5.85E-01 1.57E-02 CALM1 (includes others),ITGB3 Gαs Signaling 5.95E-01 1.60E-02 GNAO1,PTGIR Complement System 6E-01 2.70E-02 CR1 Glutathione-mediated Detoxification 6E-01 2.70E-02 GSTM3 Noradrenaline and Adrenaline Degradation 6E-01 2.70E-02 ALDH7A1 Calcium Signaling 6.14E-01 1.37E-02 CALM1 (includes others),CHRNA10,CHRNB3 Coagulation System 6.21E-01 2.86E-02 PLG Ethanol Degradation II 6.21E-01 2.86E-02 ALDH7A1 Fatty Acid β-oxidation I 6.21E-01 2.86E-02 ACAA1 Synaptogenesis Signaling Pathway 6.37E-01 0.0 1.27E-02 CALM1 (includes others),NLGN2,SNAP25,SYT12 Amyotrophic Lateral Sclerosis Signaling 6.42E-01 1.72E-02 BIRC2,BIRC3 CDK5 Signaling 6.47E-01 1.74E-02 MAPK4,PPP1CA IL-8 Signaling 6.49E-01 1.43E-02 ANGPT2,GNAO1,ITGB3 Role Of Osteoclasts In Rheumatoid Arthritis Signaling Pathway 6.59E-01 -2.0 1.30E-02 BIRC2,BIRC3,CALM1 (includes others),ITGB3 Protein Kinase A Signaling 6.66E-01 0.0 1.22E-02 CALM1 (includes others),FLNC,PPP1CA,PTPRG,PTPRK Ubiquinol-10 Biosynthesis (Eukaryotic) 6.67E-01 3.23E-02 Cyp2d22 Kinetochore Metaphase Signaling Pathway 6.7E-01 1.80E-02 H2AC21,PPP1CA ID1 Signaling Pathway 6.85E-01 1.49E-02 CHRNA10,CHRNB3,PTK7 α-Adrenergic Signaling 6.88E-01 1.85E-02 CALM1 (includes others),GNAO1 Senescence Pathway 6.89E-01 0.0 1.34E-02 CALM1 (includes others),CGAS,MAPK4,PPP1CA Adrenomedullin signaling pathway 6.94E-01 1.51E-02 CALCRL,CALM1 (includes others),MAPK4 Histidine Degradation VI 7.07E-01 3.57E-02 Cyp2d22 Sirtuin Signaling Pathway 7.1E-01 1.37E-02 MAPK4,PGK1,SOD3,WRN CREB Signaling in Neurons 7.12E-01 -0.8164965809277261 1.16E-02 ADGRG6,CALCRL,CALM1 (includes others),CELSR1,GNAO1,HCRTR2,PTGIR Virus Entry via Endocytic Pathways 7.12E-01 1.92E-02 FLNC,ITGB3 Xenobiotic Metabolism Signaling 7.17E-01 1.37E-02 ALDH7A1,GSTM3,SOD3,SULT1A2 Clathrin-mediated Endocytosis Signaling 7.2E-01 1.55E-02 ITGB3,RAB11A,TSG101 Gluconeogenesis I 7.21E-01 3.70E-02 PGK1 Glycolysis I 7.21E-01 3.70E-02 PGK1 Pregnenolone Biosynthesis 7.21E-01 3.70E-02 Cyp2d22 Tryptophan Degradation X (Mammalian, via Tryptamine) 7.21E-01 3.70E-02 ALDH7A1 Endothelin-1 Signaling 7.25E-01 1.56E-02 CASP2,GNAO1,MAPK4 Tryptophan Degradation III (Eukaryotic) 7.36E-01 3.85E-02 L3HYPDH G-Protein Coupled Receptor Signaling 7.4E-01 -0.7071067811865475 1.14E-02 ADGRG6,CALCRL,CALM1 (includes others),CELSR1,GNAO1,HCRTR2,MEGF6,PTGIR Breast Cancer Regulation by Stathmin1 7.41E-01 -0.3779644730092272 1.18E-02 ADGRG6,CALCRL,CELSR1,HCRTR2,PPP1CA,PTGIR,TSG101 Ethanol Degradation IV 7.51E-01 4.00E-02 ALDH7A1 Apelin Cardiac Fibroblast Signaling Pathway 7.84E-01 4.35E-02 ANGPT2 Erythropoietin Signaling Pathway 7.96E-01 1.69E-02 BIRC2,BIRC3,TNFSF14 Putrescine Degradation III 8.02E-01 4.55E-02 ALDH7A1 WNT/β-catenin Signaling 8.12E-01 1.72E-02 GNAO1,LRP5,LRP6 Androgen Biosynthesis 8.2E-01 4.76E-02 HSD3B2 Fatty Acid α-oxidation 8.2E-01 4.76E-02 ALDH7A1 Xenobiotic Metabolism AHR Signaling Pathway 8.32E-01 2.30E-02 ALDH7A1,GSTM3 HIPPO signaling 8.4E-01 2.33E-02 FAT4,PPP1CA TR/RXR Activation 8.57E-01 2.38E-02 FASN,SYT12 Glutaryl-CoA Degradation 8.6E-01 5.26E-02 L3HYPDH Molecular Mechanisms of Cancer 8.68E-01 1.35E-02 BIRC2,BIRC3,GNAO1,ITGB3,LRP5,LRP6 eNOS Signaling 9.13E-01 1.92E-02 CALM1 (includes others),CHRNA10,CHRNB3 Caveolar-mediated Endocytosis Signaling 9.37E-01 2.67E-02 FLNC,ITGB3 Glioma Invasiveness Signaling 9.56E-01 2.74E-02 ITGB3,PLG Melatonin Signaling 9.66E-01 2.78E-02 CALM1 (includes others),GNAO1 Serotonin Degradation 9.76E-01 2.82E-02 ALDH7A1,SULT1A2 DNA Double-Strand Break Repair by Non-Homologous End Joining 9.85E-01 7.14E-02 WRN Glucocorticoid Biosynthesis 9.85E-01 7.14E-02 HSD3B2 Mineralocorticoid Biosynthesis 1.02E00 7.69E-02 HSD3B2 γ-glutamyl Cycle 1.02E00 7.69E-02 CHAC1 Stearate Biosynthesis I (Animals) 1.02E00 2.99E-02 ASPG,FASN Phagosome Formation 1.03E00 -0.3333333333333333 1.30E-02 ADGRG6,CALCRL,CD209,CELSR1,CR1,HCRTR2,ITGB3,MAPK4,PTGIR Induction of Apoptosis by HIV1 1.04E00 3.08E-02 BIRC2,BIRC3 Sucrose Degradation V (Mammalian) 1.08E00 9.09E-02 TKFC Oxidative Ethanol Degradation III 1.14E00 3.51E-02 ALDH7A1,Cyp2d22 Lymphotoxin β Receptor Signaling 1.17E00 3.64E-02 BIRC2,TNFSF14 Phosphatidylethanolamine Biosynthesis II 1.17E00 1.11E-01 ETNK1 Xenobiotic Metabolism PXR Signaling Pathway 1.2E00 1.0 2.08E-02 ALDH7A1,GSTM3,PPP1CA,SULT1A2 Xenobiotic Metabolism CAR Signaling Pathway 1.21E00 2.0 2.09E-02 ALDH7A1,GSTM3,SOD3,SULT1A2 Triacylglycerol Biosynthesis 1.21E00 3.85E-02 ASPG,DGAT1 Superoxide Radicals Degradation 1.22E00 1.25E-01 SOD3 LPS/IL-1 Mediated Inhibition of RXR Function 1.31E00 1.97E-02 ALDH7A1,Cyp2d22,GSTM3,SOD3,SULT1A2 Apoptosis Signaling 1.32E00 2.88E-02 BIRC2,BIRC3,CASP2 Role of Macrophages, Fibroblasts and Endothelial Cells in Rheumatoid Arthritis 1.34E00 1.81E-02 CALM1 (includes others),CEBPD,GNAO1,LRP5,LRP6,TRAF3IP2 AMPK Signaling 1.39E00 2.07E-02 CHRNA10,CHRNB3,FASN,GNAO1,RAB11A Mechanisms of Viral Exit from Host Cells 1.39E00 4.88E-02 TSG101,VPS25 Death Receptor Signaling 1.41E00 3.12E-02 BIRC2,BIRC3,CASP2 Lactose Degradation III 1.42E00 2.00E-01 GLB1 Lysine Degradation II 1.42E00 2.00E-01 ALDH7A1 Lysine Degradation V 1.42E00 2.00E-01 ALDH7A1 IL-17A Signaling in Fibroblasts 1.45E00 5.26E-02 CEBPD,TRAF3IP2 RANK Signaling in Osteoclasts 1.47E00 3.30E-02 BIRC2,BIRC3,CALM1 (includes others) TWEAK Signaling 1.47E00 5.41E-02 BIRC2,BIRC3 Dopamine Degradation 1.59E00 6.25E-02 ALDH7A1,SULT1A2 TNFR2 Signaling 1.59E00 6.25E-02 BIRC2,BIRC3 Palmitate Biosynthesis I (Animals) 1.64E00 3.33E-01 FASN SNARE Signaling Pathway 1.66E00 -1.0 2.94E-02 CALM1 (includes others),RAB11A,SNAP25,SYT12 Asparagine Degradation I 1.81E00 5.00E-01 ASPG Choline Degradation I 1.81E00 5.00E-01 ALDH7A1 Fatty Acid Biosynthesis Initiation II 1.81E00 5.00E-01 FASN Pyrimidine Deoxyribonucleotides De Novo Biosynthesis I 1.86E00 8.70E-02 DUT,RRM2 Histamine Degradation 1.94E00 9.52E-02 ALDH7A1,AOC1 Role of Osteoblasts, Osteoclasts and Chondrocytes in Rheumatoid Arthritis 2.08E00 2.68E-02 BIRC2,BIRC3,CALM1 (includes others),ITGB3,LRP5,LRP6 TNFR1 Signaling 2.13E00 5.88E-02 BIRC2,BIRC3,CASP2 Upstream Regulators for My Projects->Mac - Oyster RNA-Seq->20220810_NOPP-gigas-ploidy-temp_pval_only 10:49 AM->desiccation_ploidy Analysis ID Upstream Regulator Expr Log Ratio Molecule Type Predicted Activation State Activation z-score Notes Bias Term Bias-corrected z-score p-value of overlap Target molecules in dataset Mechanistic Network desiccation_ploidy miR-127 prodrug chemical reagent 1.83E-05 FASN,NANOS1,SUSD2 desiccation_ploidy EPAS1 0.000 transcription regulator -0.589 -0.076 -0.408 4.95E-05 ANGPT2,BIRC3,DGAT1,FASN,GLB1,ITGB3,L1CAM,PLIN2,SLC16A4,TMPRSS6 desiccation_ploidy chalcone-24 chemical reagent 6.64E-05 BIRC2,BIRC3 desiccation_ploidy 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one chemical reagent 3.94E-04 BIRC2,BIRC3 desiccation_ploidy nelfinavir chemical drug Inhibited -2.186 -0.077 -2.018 5.34E-04 AKNA,CHAC1,DGAT1,MEGF10,SSPOP desiccation_ploidy ATR -0.000 kinase 5.52E-04 POLI,RRM2,WRN desiccation_ploidy mir-182 microrna -1.387 0.024 -1.440 5.65E-04 CASP2,CLEC10A,DGAT1,LRP6,NLGN2 desiccation_ploidy tunicamycin chemical - endogenous non-mammalian -1.081 -0.056 -0.944 5.68E-04 BIRC2,BIRC3,CASP2,CEBPD,CHAC1,DGAT1,FASN,LRP6,PLIN2 desiccation_ploidy MIR17HG other -0.896 0.078 -1.086 6.00E-04 BBX,CELSR1,LRP4,LRP6,PTK7,PTPRK desiccation_ploidy CTSA peptidase 6.53E-04 GLB1,SOD3 desiccation_ploidy PSAP -0.000 other 6.53E-04 BIRC2,BIRC3 desiccation_ploidy tofogliflozin chemical drug 6.53E-04 DGAT1,FASN desiccation_ploidy ACSS2 0.000 enzyme 7.36E-04 ACAA1,DGAT1,FASN desiccation_ploidy PLEKHO2 other 9.74E-04 BIRC2,BIRC3 desiccation_ploidy XPC -0.000 transcription regulator 9.74E-04 CASP2,POLI desiccation_ploidy indomethacin chemical drug 1.480 -0.031 1.566 1.22E-03 ABCA3,ANGPT2,BIRC3,DGAT1,FASN,GSTM3,KRT8,PLIN2 desiccation_ploidy IER3 other 1.36E-03 BIRC2,BIRC3 desiccation_ploidy N-acetyl-L-aspartic acid chemical - endogenous mammalian 1.36E-03 DGAT1,FASN desiccation_ploidy ST13 0.000 other 1.36E-03 CEBPD,DGAT1 desiccation_ploidy PTN growth factor 0.000 -0.092 0.184 1.38E-03 DGAT1,FASN,ITGB3,PLIN2 desiccation_ploidy BHLHE40 transcription regulator Activated 2.158 -0.062 2.331 1.40E-03 ALDH7A1,CALCRL,FASN,GSTM3,KRT8,PGK1,PLIN2,SCARF1,TNFSF14 desiccation_ploidy DIABLO other 1.80E-03 BIRC2,BIRC3 desiccation_ploidy HCFC1 0.000 transcription regulator 1.80E-03 FASN,KMT5A desiccation_ploidy SLC25A4 transporter 1.80E-03 BIRC3,CLPB desiccation_ploidy Vhl complex 1.80E-03 BIRC2,BIRC3 desiccation_ploidy nimbolide chemical - endogenous non-mammalian 1.80E-03 BIRC2,BIRC3 desiccation_ploidy ERBB2 -0.000 kinase -0.492 -0.043 -0.365 2.04E-03 ADAMTS16,AIMP2,ANGPT2,BIRC3,DGAT1,DPY19L3,FASN,FRRS1,ITGB3,L1CAM,LITAF,MAPK4,PGK1,PLIN2,POLI,PTPRK,RRM2 desiccation_ploidy STK25 -0.000 kinase 2.30E-03 FASN,PLIN2 desiccation_ploidy manassantin B chemical - endogenous non-mammalian 2.30E-03 CEBPD,FASN desiccation_ploidy HOXB5 transcription regulator 2.86E-03 ANGPT2,ITGB3 desiccation_ploidy HGF -0.000 growth factor Inhibited -2.222 -0.071 -2.025 3.31E-03 AIMP2,ANGPT2,BIRC2,BIRC3,CALCRL,CALM1 (includes others),CASP2,CELSR1,L1CAM,LGMN,PGK1 desiccation_ploidy xanthohumol chemical drug 3.40E-03 BIRC2,BIRC3,FASN desiccation_ploidy KU-55933 chemical drug 3.48E-03 GLB1,RRM2 desiccation_ploidy amodiaquine chemical drug 3.48E-03 DGAT1,FASN desiccation_ploidy PPARD 0.000 ligand-dependent nuclear receptor -0.606 -0.033 -0.527 3.48E-03 ACAA1,ANGPTL3,CYP39A1,FASN,FCGBP,LRP5,PLIN2,SERINC2 desiccation_ploidy prostaglandin E2 chemical - endogenous mammalian -0.766 -0.014 -0.726 3.55E-03 ANGPT2,BIRC3,CALCRL,CASP2,CEBPD,DGAT1,FASN,HSD3B2,TNFSF14 desiccation_ploidy sucrose chemical - endogenous mammalian 3.95E-03 FASN,SNAP25,TKFC desiccation_ploidy STK24 0.000 kinase 4.15E-03 DGAT1,FASN desiccation_ploidy tanespimycin chemical drug 1.342 0.049 1.232 4.77E-03 BIRC3,CALM1 (includes others),FASN,HNRNPM,KRT8 desiccation_ploidy TSG101 -0.357 transcription regulator 4.88E-03 RAB11A,TSG101 desiccation_ploidy gambogic acid chemical - endogenous non-mammalian 4.88E-03 BIRC2,BIRC3 desiccation_ploidy gamma-linolenic acid chemical - endogenous mammalian 4.88E-03 FASN,PLIN2 desiccation_ploidy ATF3 transcription regulator 0.371 -0.005 0.381 5.57E-03 BIRC3,CHAC1,DUT,RAB11A,RRM2 desiccation_ploidy Ck2 alpha group 5.66E-03 BIRC2,BIRC3 desiccation_ploidy D-tubocurarine chemical drug 5.66E-03 LITAF,MATR3 desiccation_ploidy dehydroxymethylepoxyquinomicin chemical reagent 5.66E-03 BIRC2,BIRC3 desiccation_ploidy glycochenodeoxycholate chemical - endogenous mammalian 5.66E-03 BIRC2,BIRC3 desiccation_ploidy noscapine chemical drug 5.66E-03 BIRC2,BIRC3 desiccation_ploidy ATP2B2 0.000 transporter 5.91E-03 FLNC,RAB11A,SOD3 desiccation_ploidy 1'-acetoxychavicol acetate chemical reagent 6.50E-03 BIRC2,BIRC3 desiccation_ploidy EHHADH 0.000 enzyme 6.50E-03 ACAA1,FASN desiccation_ploidy MAS1 g-protein coupled receptor 6.50E-03 CLEC10A,FASN desiccation_ploidy ZFTA-RELA fusion gene/product 6.68E-03 BIRC3,L1CAM,LITAF desiccation_ploidy SYVN1 -0.000 transporter -1.342 -0.090 -1.140 6.84E-03 CALM1 (includes others),FASN,HNRNPM,IFI44,L1CAM desiccation_ploidy MAPT other 7.37E-03 ASPG,B4GALT1,CALML3,DPY19L3,FASN,FLNC,FRRS1,GNAO1,IFI44,PGK1,SNAP25 desiccation_ploidy lonafarnib chemical drug 7.39E-03 BIRC2,BIRC3 desiccation_ploidy doxycycline chemical drug 7.42E-03 CEBPD,CHAC1,L1CAM,TNFSF14 desiccation_ploidy diethylnitrosamine chemical toxicant 7.44E-03 ANGPT2,BIRC2,BIRC3,GSTM3,KRT8 desiccation_ploidy MDM2 transcription regulator -0.152 -0.013 -0.127 7.99E-03 CASP2,H2BC21,TSG101,WRN desiccation_ploidy ARL6IP5 -0.000 other 8.17E-03 ITGB3 desiccation_ploidy ATM/ATR group 8.17E-03 RRM2 desiccation_ploidy BARX1 transcription regulator 8.17E-03 L1CAM desiccation_ploidy BC-DXI01 chemical reagent 8.17E-03 AIMP2 desiccation_ploidy BI 836845 biologic drug 8.17E-03 RRM2 desiccation_ploidy CAMK2 group 8.17E-03 BIRC3 desiccation_ploidy CCDC22 -0.000 other 8.17E-03 BIRC3 desiccation_ploidy CWH43 0.000 other 8.17E-03 L1CAM desiccation_ploidy DNAJC5 0.000 other 8.17E-03 SNAP25 desiccation_ploidy GSTT1 enzyme 8.17E-03 GSTM3 desiccation_ploidy KIF22 other 8.17E-03 MKX desiccation_ploidy MIR4500 microrna 8.17E-03 RRM2 desiccation_ploidy MIR5095 microrna 8.17E-03 RRM2 desiccation_ploidy PC -0.000 enzyme 8.17E-03 FASN desiccation_ploidy PPDPF other 8.17E-03 FASN desiccation_ploidy PPP1R9B -0.000 enzyme 8.17E-03 PPP1CA desiccation_ploidy Pantr2 other 8.17E-03 POU3F3 desiccation_ploidy RGL1 other 8.17E-03 PPP1CA desiccation_ploidy SAMD4B 0.000 other 8.17E-03 NANOS1 desiccation_ploidy SPAST 0.000 enzyme 8.17E-03 EMX2 desiccation_ploidy TBRG4 other 8.17E-03 RRM2 desiccation_ploidy forchlorfenuron chemical reagent 8.17E-03 SNAP25 desiccation_ploidy miR-502-5p (and other miRNAs w/seed UCCUUGC) mature microrna 8.17E-03 KMT5A desiccation_ploidy miR-99a-3p (and other miRNAs w/seed AAGCUCG) mature microrna 8.17E-03 RRM2 desiccation_ploidy procymidone chemical reagent 8.17E-03 TRPM2 desiccation_ploidy rhapontin chemical - endogenous non-mammalian 8.17E-03 FASN desiccation_ploidy vanoxerine chemical drug 8.17E-03 SOD3 desiccation_ploidy decursin chemical - endogenous non-mammalian 8.33E-03 ANGPT2,FASN desiccation_ploidy etoposide chemical drug -1.633 -0.052 -1.505 8.42E-03 BIRC2,BIRC3,CASP2,FASN,SLC16A4,WRN desiccation_ploidy Irgm1 other 0.000 0.103 -0.205 8.58E-03 CGAS,IFI44,RRM2,TRIM56 desiccation_ploidy forskolin chemical toxicant -1.246 -0.047 -1.102 9.03E-03 ADAMTS16,B4GALT1,C1QL1,CALM1 (includes others),CEBPD,FLNC,FRRS1,HSD3B2,LITAF,PGK1,RRM2,SERINC2,SNAP25 desiccation_ploidy RAB2A -0.000 enzyme 9.32E-03 FASN,PLIN2 desiccation_ploidy iloprost chemical drug 9.32E-03 ANGPT2,PTGIR desiccation_ploidy indirubin chemical drug 9.32E-03 BIRC2,BIRC3 desiccation_ploidy CDKN2A transcription regulator -0.522 0.010 -0.547 1.00E-02 CEBPD,FAM111A,FASN,GLB1,ITGB3,KIFC1,RRM2,TSG101 desiccation_ploidy EIF2S1 0.000 translation regulator 1.03E-02 CHAC1,MEGF10,SSPOP desiccation_ploidy SATB2 0.000 transcription regulator 1.03E-02 ADGRG6,IFI44,KRT8 desiccation_ploidy oblimersen biologic drug 1.03E-02 CEBPD,IFI44,SULT1A2 desiccation_ploidy ANGPTL4 -0.000 other 1.04E-02 FASN,PLIN2 desiccation_ploidy SCP2 -0.000 transporter 1.04E-02 ACAA1,PLIN2 desiccation_ploidy beta-estradiol chemical - endogenous mammalian -0.192 -0.044 0.031 1.11E-02 ABCA3,ACAA1,ALDH7A1,ANK1,B4GALT1,BIRC3,CALM1 (includes others),CEBPD,CUBN,FAM111A,FASN,FLNC,GLB1,GSTM3,H2BC21,HCRTR2,ITGB3,KRT8,L1CAM,LGMN,LITAF,MEGF11,MMRN1,PGK1,PLIN2,PTPRK,RRM2,SNAP25,SOD3,SUSD2,SYT12,THSD4 desiccation_ploidy 8-bromo-cAMP chemical reagent 0.094 -0.081 0.347 1.12E-02 AOC1,B4GALT1,BIRC3,FLNC,GLB1,HSD3B2,ITGB3,KRT8,LGMN,RRM2 desiccation_ploidy DETA-NONOate chemical reagent 1.14E-02 BIRC2,BIRC3,SOD3 desiccation_ploidy MAP2K7 -0.000 kinase 1.14E-02 ANGPT2,BIRC3,DUT desiccation_ploidy dacinostat chemical drug 1.14E-02 ANGPT2,CEBPD desiccation_ploidy SIRT1 -0.000 transcription regulator 0.379 0.037 0.283 1.16E-02 BIRC3,CLEC10A,FASN,GSTM3,HCRTR2,IFI44,NLGN2,SOD3,TSG101 desiccation_ploidy ARID1A 0.000 transcription regulator 1.17E-02 KRT8,L1CAM,LRP5,LRP6,PGK1,PTPRK desiccation_ploidy AKT1 kinase -1.746 -0.045 -1.639 1.23E-02 BIRC3,CEBPD,FASN,HNRNPM,MATR3,PLG,RAB11A desiccation_ploidy MDL 73811 chemical reagent 1.26E-02 GLB1,ITGB3 desiccation_ploidy MGLL -0.000 enzyme 1.26E-02 DGAT1,FASN desiccation_ploidy quercetin chemical drug 0.816 -0.020 0.865 1.27E-02 BCHE,BIRC3,FASN,FCGBP,KRT8,THSD4 desiccation_ploidy IKBKB 0.000 kinase -1.387 -0.066 -1.240 1.27E-02 BIRC2,BIRC3,CEBPD,FASN,ITGB3,KRT8,SOD3 desiccation_ploidy ESR2 ligand-dependent nuclear receptor -0.905 -0.030 -0.804 1.29E-02 ANK1,B4GALT1,CEBPD,DUT,FASN,GLB1,IFI44,KRT8,MAPK4,MEGF10,PLIN2,RRP12,SLC5A7 desiccation_ploidy salinosporamide A chemical drug 1.38E-02 BIRC2,BIRC3 desiccation_ploidy SUPT20H 0.000 other 1.50E-02 BIRC3,TNFSF14 desiccation_ploidy evodiamine chemical - endogenous non-mammalian 1.50E-02 BIRC2,BIRC3 desiccation_ploidy PRKAA1 kinase -1.387 0.049 -1.495 1.53E-02 BIRC3,H2BC21,HSD3B2,IFI44,LITAF desiccation_ploidy miR-182-5p (and other miRNAs w/seed UUGGCAA) mature microrna 1.55E-02 CASP2,LRP6,NLGN2 desiccation_ploidy PTK2 -0.000 kinase 1.62E-02 BIRC2,BIRC3,KRT8 desiccation_ploidy birabresib chemical drug 1.62E-02 H2BC21,IFI44,NANOS1 desiccation_ploidy ADAMTS13 peptidase 1.63E-02 ANGPT2 desiccation_ploidy AJ5012 chemical reagent 1.63E-02 FASN desiccation_ploidy BCAN 0.000 other 1.63E-02 ITGB3 desiccation_ploidy CCNDBP1 -0.000 other 1.63E-02 MKX desiccation_ploidy CHIR-124 chemical reagent 1.63E-02 RRM2 desiccation_ploidy CIDEB other 1.63E-02 PLIN2 desiccation_ploidy DBX1 0.000 transcription regulator 1.63E-02 TNFSF14 desiccation_ploidy DDX41 -0.000 enzyme 1.63E-02 CGAS desiccation_ploidy HSD17B13 enzyme 1.63E-02 FASN desiccation_ploidy IPP-204106N chemical drug 1.63E-02 ANGPT2 desiccation_ploidy LILRB2 transmembrane receptor 1.63E-02 FASN desiccation_ploidy METTL5 enzyme 1.63E-02 CALM1 (includes others) desiccation_ploidy PS-K chemical drug 1.63E-02 BIRC2 desiccation_ploidy SELENOH 0.000 other 1.63E-02 GLB1 desiccation_ploidy SENP5 0.000 peptidase 1.63E-02 BIRC2 desiccation_ploidy SNF8 0.000 enzyme 1.63E-02 VPS25 desiccation_ploidy TAT -0.000 enzyme 1.63E-02 GLB1 desiccation_ploidy TIMM50 0.000 phosphatase 1.63E-02 HSD3B2 desiccation_ploidy TRIM54 0.000 other 1.63E-02 FLNC desiccation_ploidy ZBTB14 -0.000 transcription regulator 1.63E-02 TNFSF14 desiccation_ploidy ZM 306416 chemical drug 1.63E-02 ANGPT2 desiccation_ploidy clofazimine chemical drug 1.63E-02 PLIN2 desiccation_ploidy desflurane chemical drug 1.63E-02 BIRC2 desiccation_ploidy miltefosine chemical drug 1.63E-02 ABCA3 desiccation_ploidy BRD7 -0.000 transcription regulator 1.63E-02 FASN,KRT8 desiccation_ploidy NRG (family) group 1.63E-02 CHRNA10,CHRNB3 desiccation_ploidy UBA1 -0.000 enzyme 1.63E-02 BIRC2,BIRC3 desiccation_ploidy zerumbone chemical - endogenous non-mammalian 1.63E-02 BIRC2,BIRC3 desiccation_ploidy prednisolone chemical drug 0.000 0.044 -0.109 1.67E-02 BIRC2,BIRC3,CASP2,CEBPD,PGK1,SOD3 desiccation_ploidy paraquat chemical toxicant -0.927 -0.060 -0.808 1.70E-02 ANGPT2,CEBPD,LRP4,SOD3 desiccation_ploidy HOXA10 transcription regulator 0.342 0.032 0.272 1.74E-02 AIMP2,BCHE,EMX2,ITGB3,TNXB desiccation_ploidy SOX7 -0.000 transcription regulator 1.75E-02 CALCRL,EMX2,LRP5 desiccation_ploidy COMMD1 -0.000 transporter 1.76E-02 BIRC3,PGK1 desiccation_ploidy HSD17B4 0.000 enzyme 1.76E-02 ACAA1,FASN desiccation_ploidy plumbagin chemical drug 1.76E-02 BIRC2,BIRC3 desiccation_ploidy tosylphenylalanyl chloromethyl ketone chemical - protease inhibitor 1.76E-02 BIRC2,BIRC3 desiccation_ploidy metribolone chemical reagent -0.236 -0.078 -0.022 1.79E-02 ACAA1,ADRM1,AKNA,B4GALT1,FASN,KMT5A,PGK1,RRP12,TRIM36 desiccation_ploidy IL6 cytokine -0.187 -0.054 -0.028 1.84E-02 C1QL1,CD209,CEBPD,CLEC10A,FGL1,FRRS1,ITGB3,KIFC1,KRT8,LRP6,PLG,REG1A,RRM2 desiccation_ploidy fatty acid chemical - endogenous mammalian 0.895 -0.071 1.038 1.89E-02 AOC1,DGAT1,FASN,PLIN2 desiccation_ploidy USP19 -0.000 peptidase 1.90E-02 BIRC2,BIRC3 desiccation_ploidy miR-128-3p (and other miRNAs w/seed CACAGUG) mature microrna 1.90E-02 PTPRG,SNAP25 desiccation_ploidy 3-deazaneplanocin chemical drug 1.97E-02 AKNA,SLC5A7,SNX33 desiccation_ploidy GW3965 chemical reagent 0.625 0.007 0.611 2.00E-02 ANGPTL3,FASN,PLIN2,TNFSF14 desiccation_ploidy CA4 enzyme 2.18E-02 ANK1,PNLIP desiccation_ploidy HMOX1 enzyme Inhibited -2.000 0.015 -2.030 2.21E-02 ANGPT2,ANGPTL3,ITGB3,TNFSF14 desiccation_ploidy OGA -0.000 enzyme -1.414 0.010 -1.442 2.30E-02 ADRM1,CALCRL,CASP2,CELSR1,COLEC11,LRP4,MMRN2,PLIN2 desiccation_ploidy MAP2K1 0.000 kinase 2.31E-02 BIRC2,BIRC3,FASN,ITGB3,RRM2 desiccation_ploidy NR5A2 -0.000 ligand-dependent nuclear receptor 0.338 -0.061 0.455 2.32E-02 CEBPD,FASN,HSD3B2,PNLIP desiccation_ploidy GABARAPL2 0.000 other 2.33E-02 LGMN,SERINC2 desiccation_ploidy PRKDC -0.000 kinase 2.33E-02 BIRC3,FASN desiccation_ploidy 25-hydroxycholesterol chemical reagent 2.36E-02 ANGPTL3,CHAC1,FASN desiccation_ploidy ATOX1 transporter 2.43E-02 SOD3 desiccation_ploidy Ank2 other 2.43E-02 L1CAM desiccation_ploidy BCLAF3 other 2.43E-02 REG1A desiccation_ploidy CARD8 other 2.43E-02 BIRC2 desiccation_ploidy CK1 group 2.43E-02 BIRC2 desiccation_ploidy F5 other 2.43E-02 MMRN1 desiccation_ploidy H1-1 other 2.43E-02 GLB1 desiccation_ploidy IRS group 2.43E-02 DGAT1 desiccation_ploidy IRX1 transcription regulator 2.43E-02 H2BC21 desiccation_ploidy PAGR1 other 2.43E-02 CEBPD desiccation_ploidy PBK kinase 2.43E-02 BIRC3 desiccation_ploidy Pick1 other 2.43E-02 AIMP2 desiccation_ploidy RAB3B enzyme 2.43E-02 SNAP25 desiccation_ploidy SRT2104 chemical drug 2.43E-02 TSG101 desiccation_ploidy VAMP7 0.000 transporter 2.43E-02 L1CAM desiccation_ploidy ixabepilone chemical drug 2.43E-02 BIRC2 desiccation_ploidy tolylfluanid chemical toxicant 2.43E-02 FASN desiccation_ploidy GABARAPL1 other 2.48E-02 LGMN,SERINC2 desiccation_ploidy JINK1/2 group 2.48E-02 FASN,PLG desiccation_ploidy LPIN1 phosphatase 2.48E-02 DGAT1,FASN desiccation_ploidy PD 123319 chemical drug 2.48E-02 ANGPT2,FASN desiccation_ploidy carbohydrate chemical - endogenous mammalian 2.48E-02 FASN,TKFC desiccation_ploidy GABARAP -0.000 transporter 2.64E-02 LGMN,SERINC2 desiccation_ploidy MDM4 -0.000 transcription regulator 2.64E-02 CELSR1,KRT8 desiccation_ploidy molybdenum disulfide chemical reagent 1.000 0.044 0.912 2.80E-02 ABCA3,IFI44,L1CAM,MEGF6 desiccation_ploidy PTTG1 transcription regulator 2.87E-02 CEBPD,POLI,WRN desiccation_ploidy NF-Y complex 2.97E-02 EMX2,FASN,RRM2 desiccation_ploidy NRXN1 0.000 transporter 2.97E-02 MMRN1,NCAN desiccation_ploidy NOTCH1 1.552 transcription regulator -1.109 -0.020 -1.067 3.00E-02 BIRC2,BIRC3,CEBPD,KRT8,PGK1,PTPRK desiccation_ploidy GATA6 0.000 transcription regulator 0.762 -0.002 0.765 3.04E-02 CLEC10A,EMX2,Fcna,HSD3B2,PGK1 desiccation_ploidy ACOX1 0.000 enzyme 0.105 0.019 0.067 3.13E-02 ACAA1,FASN,KRT8,PLIN2 desiccation_ploidy FGFR4 0.000 kinase 3.14E-02 DGAT1,FASN desiccation_ploidy SOST other 3.14E-02 FASN,PLIN2 desiccation_ploidy ZBED6 transcription regulator 3.14E-02 ANKRD50,MB21D2 desiccation_ploidy bryostatin 1 chemical drug 3.14E-02 BIRC3,CD209 desiccation_ploidy 1-(2-hydroxy-5-methylphenyl)-3-phenyl-1,3-propanedione chemical reagent 3.23E-02 CEBPD desiccation_ploidy 4beta-hydroxycholesterol chemical - endogenous mammalian 3.23E-02 FASN desiccation_ploidy APPL1 -0.000 other 3.23E-02 SNAP25 desiccation_ploidy ASCC1 -0.000 transcription regulator 3.23E-02 BIRC2 desiccation_ploidy CCDC3 other 3.23E-02 FASN desiccation_ploidy CLASP2 other 3.23E-02 SNAP25 desiccation_ploidy CTNNAL1 0.000 other 3.23E-02 ITGB3 desiccation_ploidy FASTK kinase 3.23E-02 BIRC2 desiccation_ploidy GPR55 g-protein coupled receptor 3.23E-02 FASN desiccation_ploidy IBSP other 3.23E-02 ITGB3 desiccation_ploidy MK-8776 chemical drug 3.23E-02 RRM2 desiccation_ploidy Mt3 other 3.23E-02 CEBPD desiccation_ploidy RNF139 0.000 enzyme 3.23E-02 FASN desiccation_ploidy SHBG other 3.23E-02 FASN desiccation_ploidy SRT2183 chemical reagent 3.23E-02 FASN desiccation_ploidy TOP2B enzyme 3.23E-02 FASN desiccation_ploidy USP27X peptidase 3.23E-02 CGAS desiccation_ploidy VLDL complex 3.23E-02 PLIN2 desiccation_ploidy ZSCAN4 transcription regulator 3.23E-02 TNFSF14 desiccation_ploidy beta,beta-dimethylacrylshikonin chemical reagent 3.23E-02 BIRC3 desiccation_ploidy hemicholinium 3 chemical reagent 3.23E-02 SLC5A7 desiccation_ploidy triacsin C chemical reagent 3.23E-02 PLIN2 desiccation_ploidy PPARGC1A transcription regulator 1.183 -0.023 1.241 3.24E-02 CALM1 (includes others),CEBPD,DGAT1,EMILIN2,FASN,HSD3B2,PLIN2,SVEP1 desiccation_ploidy 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine chemical reagent 3.31E-02 BIRC2,BIRC3 desiccation_ploidy trabectedin chemical drug 3.31E-02 LGMN,WRN desiccation_ploidy NFYA 0.000 transcription regulator 3.35E-02 FASN,PGK1,RRM2 desiccation_ploidy APP -0.000 other -0.447 -0.037 -0.364 3.43E-02 CALML3,DPY19L3,GNAO1,GSTM3,ITGB3,L1CAM,LRP5,LRP6,P2rx7,PGK1,POU3F3,SNAP25,THSD4,TPPP3 desiccation_ploidy KDM1A 0.000 enzyme 3.44E-02 B4GALT1,FASN,FLNC,FRRS1,IFI44,KRT8,SNAP25 desiccation_ploidy MAFB transcription regulator 3.45E-02 FCGBP,LGMN,PTGIR desiccation_ploidy SCAP 0.000 other 3.55E-02 ABCA3,FASN,REG1A desiccation_ploidy ERN1 -0.000 kinase -0.747 -0.054 -0.640 3.55E-02 CEBPD,DGAT1,FASN,PLIN2 desiccation_ploidy N6AMT1 enzyme 0.000 -0.103 0.205 3.55E-02 ALDH7A1,ANGPT2,POLI,ZMYM1 desiccation_ploidy NFKBIA -0.000 transcription regulator 0.522 -0.026 0.591 3.57E-02 BIRC2,BIRC3,CEBPD,KRT8,LITAF,NCAN,SOD3,TNFSF14 desiccation_ploidy DUSP1 -0.000 phosphatase -0.152 0.032 -0.216 3.63E-02 CLEC10A,IFI44,PLIN2,PTPRK desiccation_ploidy NEDD9 -0.000 other 3.65E-02 PGK1,PLIN2,TPPP3 desiccation_ploidy IL20 cytokine 3.67E-02 FGL1,PLG desiccation_ploidy benzo(a)pyrene chemical toxicant 3.71E-02 ADAMTS16,FASN,GNAO1,PTPRG,SOD3 desiccation_ploidy CTF1 cytokine 3.85E-02 CEBPD,FASN desiccation_ploidy SN-38 chemical drug 3.85E-02 BIRC2,BIRC3 desiccation_ploidy PGR ligand-dependent nuclear receptor -1.724 -0.053 -1.597 3.91E-02 BIRC2,BIRC3,CEBPD,GSTM3,IFI44,SNAP25 desiccation_ploidy IKBKE -0.325 kinase 3.97E-02 BIRC2,BIRC3,PGK1 desiccation_ploidy Arg-Gly-Asp chemical reagent 4.02E-02 ITGB3 desiccation_ploidy Collagen type V complex 4.02E-02 ITGB3 desiccation_ploidy DASA-58 chemical reagent 4.02E-02 FASN desiccation_ploidy GYS2 0.000 enzyme 4.02E-02 FASN desiccation_ploidy HU-210 chemical reagent 4.02E-02 FASN desiccation_ploidy Mamld1 other 4.02E-02 HSD3B2 desiccation_ploidy PSMB1 -0.000 peptidase 4.02E-02 REG1A desiccation_ploidy RAD51C -0.000 enzyme 4.02E-02 KRT8 desiccation_ploidy SIRT group 4.02E-02 FASN desiccation_ploidy ZNF598 -0.000 enzyme 4.02E-02 IFI44 desiccation_ploidy butylphen chemical toxicant 4.02E-02 RSL24D1 desiccation_ploidy saxagliptin chemical drug 4.02E-02 TRAF3IP2 desiccation_ploidy vinclozolin chemical reagent 4.02E-02 TRPM2 desiccation_ploidy 22(R)-hydroxycholesterol chemical - endogenous mammalian 4.04E-02 ANGPTL3,FASN desiccation_ploidy CIDEC other 4.04E-02 DGAT1,FASN desiccation_ploidy piceatannol chemical - endogenous non-mammalian 4.04E-02 ANGPT2,BIRC3 desiccation_ploidy thalidomide chemical drug 4.04E-02 ANGPT2,BIRC3 desiccation_ploidy elaidic acid chemical - endogenous mammalian 4.08E-02 ANGPTL3,DGAT1,FASN desiccation_ploidy E2F4 0.000 transcription regulator 4.08E-02 CALM1 (includes others),DUT,H2BC21,PRKCSH,RRM2 desiccation_ploidy SREBF2 transcription regulator 4.19E-02 FASN,PLIN2,REG1A desiccation_ploidy nicotine chemical drug 4.21E-02 FASN,GNAO1,HCRTR2,LITAF,MATR3 desiccation_ploidy DSCAM 0.000 other 4.30E-02 L1CAM,NLGN2,SYT12 desiccation_ploidy cisplatin chemical drug -1.450 -0.042 -1.315 4.34E-02 ADRM1,ANK1,BIRC2,BIRC3,FASN,GSTM3,L1CAM,LRP6,MEGF10,MEGF6,RRM2,SUSD2 desiccation_ploidy DYSF 0.000 other 4.41E-02 DGAT1,FASN,ITGB3 desiccation_ploidy NCOA3 0.000 transcription regulator 4.41E-02 FASN,PGK1,PLIN2 desiccation_ploidy SNAI1 transcription regulator 4.41E-02 FASN,FLNC,KRT8,L1CAM desiccation_ploidy LG100268 chemical reagent 4.42E-02 BIRC2,PLIN2 desiccation_ploidy NR0B1 -0.000 ligand-dependent nuclear receptor 4.42E-02 FASN,HSD3B2 desiccation_ploidy PAX8 transcription regulator 4.42E-02 L1CAM,TNFSF14 desiccation_ploidy PGF growth factor 4.42E-02 BIRC2,NANOS1 desiccation_ploidy T3-TR-RXR complex 4.42E-02 FASN,SYT12 desiccation_ploidy epicatechin chemical drug 4.52E-02 PLIN2,SNAP25,SVEP1 desiccation_ploidy KRAS enzyme 4.54E-02 ABCA3,AIMP2,BIRC3,CASP2,CLEC10A,DPY19L3,FASN,GSTM3,ITGB3,L1CAM,PPP1CA,SOD3 desiccation_ploidy PSEN1 -0.000 peptidase 4.55E-02 CALML3,DPY19L3,GNAO1,L1CAM,PGK1,SNAP25,TNXB desiccation_ploidy valproic acid chemical drug 1.496 -0.004 1.508 4.58E-02 ADRM1,B4GALT1,CD209,Cyp2d22,CYP39A1,HSD3B2,TENM3,THSD4 desiccation_ploidy ELAVL1 other 4.61E-02 CACHD1,CALM1 (includes others),CASP2,DGAT1,IFI44 desiccation_ploidy KDM3A transcription regulator 4.62E-02 FLNC,TNXB desiccation_ploidy PCGEM1 other 4.62E-02 FASN,PGK1 desiccation_ploidy S-nitrosoglutathione chemical toxicant 4.62E-02 BIRC2,BIRC3 desiccation_ploidy fisetin chemical drug 4.62E-02 BIRC2,BIRC3 desiccation_ploidy medroxyprogesterone acetate chemical drug 0.000 -0.067 0.188 4.63E-02 ANGPT2,B4GALT1,BIRC3,FASN,FLNC,GLB1,ITGB3,LGMN desiccation_ploidy ADCYAP1 other -0.447 -0.023 -0.396 4.68E-02 CEBPD,FRRS1,KRT8,MAPK4,SNAP25 desiccation_ploidy HDAC3 0.000 transcription regulator 4.76E-02 BIRC3,FASN,PLIN2 desiccation_ploidy TSC1 -0.000 other 4.76E-02 AGA,FASN,LITAF desiccation_ploidy 2,2'-dipyridyl chemical toxicant 4.80E-02 TMPRSS6 desiccation_ploidy CCAR1 0.000 transcription regulator 4.80E-02 CEBPD desiccation_ploidy CDHR1 0.000 other 4.80E-02 CEBPD desiccation_ploidy COIL enzyme 4.80E-02 H2AC21 desiccation_ploidy CV 3988 chemical reagent 4.80E-02 ITGB3 desiccation_ploidy Fructus xanthii aqueous extract chemical - endogenous non-mammalian 4.80E-02 FASN desiccation_ploidy Hmgb2 (includes others) transcription regulator 4.80E-02 CASP2 desiccation_ploidy Hrg other 4.80E-02 ANGPT2 desiccation_ploidy Irs3 other 4.80E-02 FASN desiccation_ploidy MAP4K1 kinase 4.80E-02 BIRC3 desiccation_ploidy OBP2B transporter 4.80E-02 FASN desiccation_ploidy Rp-8-pCPT-cGMPS-triethylamine chemical reagent 4.80E-02 SOD3 desiccation_ploidy SENP6 -0.000 peptidase 4.80E-02 BIRC2 desiccation_ploidy SWI-SNF complex 4.80E-02 RRM2 desiccation_ploidy ZNF395 transcription regulator 4.80E-02 IFI44 desiccation_ploidy juglone chemical toxicant 4.80E-02 FASN desiccation_ploidy miR-3118 (and other miRNAs w/seed GUGACUG) mature microrna 4.80E-02 GNAO1 desiccation_ploidy mir-488 microrna 4.80E-02 PRKCSH desiccation_ploidy myristic acid chemical - endogenous mammalian 4.80E-02 PLIN2 desiccation_ploidy osimertinib chemical drug 4.80E-02 FASN desiccation_ploidy vaccenic acid chemical - endogenous mammalian 4.80E-02 PLIN2 desiccation_ploidy ABCB6 -0.000 transporter 4.82E-02 Cyp2d22,CYP39A1 desiccation_ploidy NFU1 0.000 other 4.82E-02 DGAT1,FASN desiccation_ploidy SLC27A2 transporter 4.82E-02 ACAA1,PLIN2 desiccation_ploidy pituitary adenylate cyclase-activating polypeptide biologic drug 4.82E-02 C1QL1,FRRS1 desiccation_ploidy TWIST1 -0.000 transcription regulator Activated 2.000 -0.038 2.076 5.01E-02 CELSR1,FAT4,FCGBP,ITGB3 desiccation_ploidy trans-hydroxytamoxifen chemical drug Activated 2.000 0.017 1.967 6.14E-02 ANGPT2,H2BC21,L1CAM,LITAF desiccation_ploidy hydrogen peroxide chemical - endogenous mammalian Inhibited -2.157 -0.054 -2.008 8.73E-02 BIRC3,DUT,FASN,GSTM3,ITGB3,LRP6,PPP1CA,PRKCSH desiccation_ploidy IRF3 transcription regulator 1.982 -0.081 2.143 9.25E-02 ANOS1,BIRC2,BIRC3,IFI44 desiccation_ploidy estradiol-17beta-benzoate chemical reagent Activated 2.000 -0.041 2.081 9.88E-02 C1QTNF4,GSTM3,PTPRG,TNXB desiccation_ploidy CITED2 transcription regulator -1.981 0.086 -2.151 1.13E-01 BBX,CLEC10A,IFI44,PGK1 desiccation_ploidy N-acetyl-L-cysteine chemical drug 1.982 0.062 1.860 1.63E-01 BIRC2,BIRC3,FASN,GLB1 desiccation_ploidy Interferon alpha group 1.980 -0.073 2.124 1.96E-01 BCHE,CD209,CELSR1,CGAS,FASN,GSTM3,IFI44 desiccation_ploidy D-glucose chemical - endogenous mammalian -1.820 -0.031 -1.737 2.90E-01 ACAA1,ANGPT2,FASN,PGK1,RRM2,SLC16A4,SNAP25,SUSD2 desiccation_ploidy progesterone chemical - endogenous mammalian Inhibited -2.387 -0.026 -2.326 3.34E-01 BIRC3,CEBPD,FAM111A,ITGB3,LITAF,RRM2,TNXB desiccation_ploidy FOS transcription regulator -1.976 -0.033 -1.911 3.46E-01 B4GALT1,FASN,HSD3B2,KRT8,MMRN1,NUBP1 desiccation_ploidy CREB1 transcription regulator Inhibited -2.161 -0.035 -2.085 5.12E-01 CEBPD,FASN,LITAF,MGAT4C,SERINC2 desiccation_ploidy SMARCA4 transcription regulator 1.964 -0.085 2.131 1.00E00 PLIN2,RRM2,SOD3,TRIM36 desiccation_ploidy dihydrotestosterone chemical - endogenous mammalian -1.982 -0.043 -1.896 1.00E00 FASN,HSD3B2,PTK7,SLC16A7,SOD3 Causal Networks for My Projects->Mac - Oyster RNA-Seq->20220810_NOPP-gigas-ploidy-temp_pval_only 10:49 AM->desiccation_ploidy Master Regulator Molecule Type Expr Log Ratio Depth Predicted Activation State Notes Activation z-score p-value of overlap Network bias-corrected p-value Participating regulators Target molecules in dataset Causal network Target-connected regulators Relationships Between Master Regulators(Increases/Downstream) Relationships Between Master Regulators(Decreases/Downstream) Relationships Between Master Regulators(Affects/Downstream) Relationships Between Master Regulators(Increases/Upstream) Relationships Between Master Regulators(Decreases/Upstream) Relationships Between Master Regulators(Affects/Upstream) Relationships Between Master Regulators(Increases/Both) Relationships Between Master Regulators(Decreases/Both) Relationships Between Master Regulators(Affects/Both) KN 93 chemical drug 3 1.937 1.20E-07 1.00E-04 26s Proteasome,Akt,AKT1,Ap1,ATF3,ATF4,CAMK2A,CaMKII,CASP3,CDK1,CDK4,CDKN1B,CDKN2A,CFLAR,CITED2,Creb,CREB1,CTNNB1,CXCL8,DICER1,EGLN,EIF2AK2,ELAVL1,ERK,ERK1/2,ESR1,ETS2,FADD,FOXO3,GNE,HDAC4,HIF1A,HIPK2,HNF1A,HNF4A,HRAS,IFNAR1,IFNG,IGF1,IL10,IL2,IRF3,Jnk,JUN,KN 93,MAP3K5,MAP3K7,MAPK1,MAPK14,MAPK3,MAPT,MITF,MYB,NFATC2,NFKBIA,NGEF,NRAS,P38 MAPK,PDPK1,Pkc(s),PPARGC1A,PRKCE,PTK2B,RB1,RICTOR,SNCA,SOX2,SPARC,STK11,TCF7L2,TNF,TNFSF11,TWIST1 ACAA1,ADGRG6,ADRM1,AIMP2,ANGPT2,ANK1,ANOS1,AOC1,ASPG,ATL2,B4GALT1,BBX,C1QL1,CACHD1,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,DPY19L3,EMX2,ETNK1,FAM111A,FCGBP,FGL1,FLNC,FRRS1,FUT6,H2AC21,H2BC21,HNRNPM,ITGB3,KIFC1,KMT5A,KRT8,LITAF,LRP5,LRP6,MAPK4,MATR3,MEGF11,MGAT4C,MKX,NCAN,PGK1,PIF1,PKD1L2,PLG,PLIN2,POLI,PTGIR,PTPRK,RAB11A,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SOD3,SUSD2,SVEP1,TENM3,TMPRSS6,TNFSF14,TRIM2,TRIM3,TRIM56,TRPM2,TULP4,VPS25,XPO7 77 (73) 61 Cofilin AKT1,ATF2,CALC,CAMK2,CASP3,HAS2,LHB,MAP3K7,PEA15 LRP8 transmembrane receptor 3 -0.651 1.50E-07 2.00E-04 AHR,AKT1,ALK,Ap1,APP,AR,CD3,CDKN1B,CTNNB1,ESR2,ETS2,FGFR2,FGFR4,GRIN3A,HIF1A,HIPK2,HMOX1,HRAS,IGF1R,INSR,IRF3,KLF4,L-tyrosine,LRP8,MAPK8,MAPT,MDM2,MYC,NFATC2,NFKB1,NFKBIA,NMDA Receptor,NR1I3,NRAS,PAWR,PDPK1,PGR,PP2A,PPARG,PRKCE,PRMT1,PTK,RAF1,Sfk,SLC6A4,SNCA,SOX2,SPARC,SRC (family),TLR3,TNFSF11,TP53,TWIST1 ABCA3,ANGPTL3,ANOS1,ASPG,BBX,BCHE,BIRC3,C1QL1,CALM1 (includes others),CEBPD,CHAC1,CHRNB3,CLPB,CSMD3,CUBN,Cyp2d22,CYP39A1,DGAT1,DUT,EMILIN2,EMX2,FASN,FCGBP,FRRS1,GNAO1,GSTM3,H2BC21,HCRTR2,HNRNPM,HSD3B2,ITGB3,LGMN,LRP4,LRP5,MATR3,MEGF11,MKX,MMRN1,NCAN,PLG,POU3F3,PPP1CA,RAB11A,RRP12,SLC16A4,SLC16A7,SLC5A7,SUSD2,SYT12,TENM3,THSD4,TMPRSS6,TNR,TPPP3,TRIM2,TRIM3,TULP4,VPS25,XPO7 59 (53) 47 AKT1,NMDA Receptor SOD1 enzyme 0.000 3 -0.762 1.34E-06 5.00E-04 26s Proteasome,ACHE,AHR,Akt,AMPK,Ap1,APP,ATF4,beta-estradiol,Calcineurin protein(s),CASP3,CASP9,CDKN1B,CEBPA,CEBPB,CFTR,CREB1,CXCL8,DICER1,DLX5,ELAVL1,ESR2,FOS,glutathione peroxidase,GSTK1,Hdac,HRAS,IGF1,IL1B,IL2,IL6,INSR,MAPK8,MAPT,MDM2,MLXIPL,MYC,NFATC2,NFkB (complex),NFKB2,NGEF,NR1I2,PAK2,PDPK1,PPARGC1A,PPP3CA,PPP3R1,PRKAA,PSMB1,RB1,REL,RET,RICTOR,RXRA,SOD1,SOD2,STAT1,STAT4,TSC1,TWIST1 ABCA5,ADRM1,AGA,AIMP2,ALDH7A1,ANGPT2,ANGPTL3,ASPG,ATL2,B4GALT1,BBX,BIRC3,C1QTNF3,CACHD1,CALM1 (includes others),CASP2,CEBPD,CGAS,CHAC1,CLPB,CR1,CUBN,Cyp2d22,CYP39A1,DGAT1,EMILIN2,FAM111A,FASN,FAT4,FCGBP,FGL1,KRT8,L1CAM,LGMN,LRP4,LRP5,MAPK4,MEGF10,MEGF11,MGAT4C,MMRN1,NUBP1,PLG,POU3F3,PTGIR,RAB11A,REG1A,RRP12,RSL24D1,SCARF1,SERINC2,SLC5A7,SOD3,SVEP1,TENM3,THSD4,TKFC,TNFSF14,TPPP3,TRAF3IP2,TSG101,WRN 62 (60) 54 BTG2,EPAS1,HNF4A,paraquat,quercetin,SOST,VEGFB 1-methyl-4-phenylpyridinium,carbon tetrachloride,INS,prednisolone,propofol PPP3CA,prostaglandin E2 CDKN2A,CGB3 (includes others),iron,NFkB (complex) LRP6 transmembrane receptor 1.614 3 0.630 1.48E-06 5.00E-04 ACHE,Akt,Alpha catenin,APP,CDKN1B,CEBPA,CREB1,CTNNB1,CYP19A1,EIF4E,ERK,ERK1/2,ESR2,ETS2,FADD,FOS,FOXA1,GSK3B,HIF1A,HNF1A,HNF4A,IFNAR1,IL10,IRF3,Jnk,JUN,KLF6,KRT8,LEF1,LGALS3,LRP6,MAPK14,MAPT,MITF,MTORC1,MYOD1,NGEF,PPARGC1A,RB1,RXRA,S100A9,SIRT1,SREBF2,STAT1,STK11,TCF4,TCF7L2,TNF,transcription factor,VAMP8,VDR,YAP1 ACAA1,ADGRG6,ADRM1,AIMP2,ANGPT2,ANGPTL3,ANOS1,AOC1,ASPG,BCHE,BIRC3,C1QTNF3,CASP2,CD209,CEBPD,CGAS,CLEC10A,CLPB,CR1,CUBN,EMILIN2,EMX2,ETNK1,FAM111A,FGL1,FUT6,GNAO1,HCRTR2,ITGB3,KIFC1,KMT5A,L1CAM,Lgals6,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NANOS1,NLGN2,NUBP1,PGK1,PIF1,PKD1L2,PLG,PLIN2,POLI,PRKCSH,RAB11A,REG1A,RRP12,SCARF1,SLC16A4,SLC5A7,SUSD2,SVEP1,THSD4,TMPRSS6,TNFSF14,TNR,TPPP3,TRIM2,TRIM56 63 (52) 48 CCN5,CK1,EXT1,FSTL1,LRP5,phorbol 12,13-dibutyrate,tanespimycin,WNT1,WNT3A chondroitin sulfate E,huaier extract granule,mir-182,miR-182-5p (and other miRNAs w/seed UUGGCAA),MIR17-92,MIR17HG,tunicamycin,WNT5A MMP7 KRT18 ANGPT1 growth factor 0.000 3 Inhibited -3.010 4.85E-06 1.00E-03 26s Proteasome,ACHE,AHR,Akt,ANGPT1,APP,CASP3,CD24,CDC42,CDKN1B,CDKN2A,CEBPA,CITED2,CREB1,CTNNB1,CXCL8,CYP1A2,DICER1,ELAVL1,EPAS1,ERK,ERK1/2,ESR2,ETS2,FADD,FOS,Hdac,HIF1A,HNF1A,HNF4A,HRAS,hydrogen peroxide,IFNAR1,IFNG,IGF1,IL6,IL6ST,INSR,Integrin,Interferon alpha,Jnk,L-triiodothyronine,L-tyrosine,MAP2K1,Mapk,MAPK1,MAPK14,MAPK3,Mek,MITF,MYB,MYOD1,NFATC2,NGEF,P38 MAPK,p70 S6k,PDPK1,PI3K (complex),PPARA,PPARGC1A,PRKCE,RAC1,RAF1,RAS,Ras homolog,RB1,REL,RHOA,RICTOR,ROCK1,S100A9,STK11,TAFAZZIN,TCF7L2,TGFB1,TNF,TWIST1 ADGRG6,ADRM1,AGA,AIMP2,ANGPT2,ANK1,AOC1,ATL2,BBX,BCHE,BIRC2,BIRC3,CACHD1,CALCRL,CALML3,CASP2,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,EMILIN2,ETNK1,FAM111A,FCGBP,FGL1,FLNC,FUT6,H2AC21,IFI44,KMT5A,KRT8,L1CAM,Lgals6,LRP4,LRP5,LRP6,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NUBP1,PIF1,PKD1L2,PRKCSH,PTPRK,RAB11A,REG1A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SSPOP,SUSD2,SVEP1,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TPPP3,TRIM2,TRIM56 69 (77) 63 FOXO4,GRN,POU5F1,PROCR,prostaglandin E2 CNTF,glyceollin,HMOX1,indomethacin,MEOX2,tacrolimus,WNT3A CDH5,TIE1 CASP3,FASLG cocaine chemical drug 2 -1.219 5.73E-06 6.00E-04 Akt,AKT1,Ap1,BCL2,CDK5,cocaine,Creb,CREB1,dopamine,DUSP1,ERK,ERK1/2,FOS,MAPK3,MAPK9,MAPT,P38 MAPK,PRKCE,SRC,STAT ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,ASPG,B4GALT1,BIRC2,CALM1 (includes others),CEBPD,CHRNB3,CLEC10A,DPY19L3,GLB1,HNRNPM,HSD3B2,IFI44,ITGB3,KRT8,L1CAM,LITAF,MATR3,MGAT4C,NUBP1,PGK1,PLG,PPP1CA,PTPRK,RRM2,SERINC2,SNAP25,SOD3,TNFSF14 33 (20) 19 AKT1,BHLHE40,CASP3,CASR,GRM5,LOC102724428/SIK1,mir-154,mir-488,NMDA Receptor,PDGFB,Sik1 GPSM1,NPY,SLC6A3 LOXO-195 chemical drug 3 1.441 6.90E-06 1.30E-03 ACHE,Akt,AKT1,Creb,CREB1,ERK,ERK1/2,HRAS,Jnk,JUN,KRAS,LOXO-195,MAPK1,Mek,NFkB (complex),NRAS,NTRK1,NTRK2,P38 MAPK,p85 (pik3r),Pkc(s),PPARG,RHOB,SRC,Trk Receptor ACAA1,ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,BIRC2,CALCRL,CASP2,CD209,CEBPD,CLEC10A,DGAT1,DPY19L3,FASN,FLNC,HNRNPM,IFI44,ITGB3,KRT8,L1CAM,LITAF,MATR3,MGAT4C,PGK1,PLIN2,POLI,PPP1CA,PTPRK,RRM2,SERINC2,SLC5A7,SNAP25,SOD3,TENM3,TNFSF14,TULP4,VPS25 39 (25) 22 NTRK1 SENP2 peptidase 3 -1.576 7.45E-06 2.30E-03 26s Proteasome,ACHE,AHR,Akt,Alpha catenin,APC,APP,AR,CDKN1B,CDKN2A,CEBPA,CEBPB,CTNNB1,CXCL8,DDX58,DLX5,EIF2AK3,ESR2,estrogen receptor,HIPK2,IFIH1,IKK (complex),IL1B,IL6,INSR,MAPK1,MAPK8,MAVS,MDM2,MYC,NFATC2,NFkB (complex),NFKB2,NFKBIA,NGEF,NR1I2,PRKAA,RB1,RICTOR,RXRA,SENP2,STAT4,TCF7L2,TSG101,TWIST1,VDR ACAA1,ADRM1,AIMP2,ALDH7A1,ANGPTL3,BBX,BIRC2,C1QTNF3,CASP2,CEBPD,CGAS,CLPB,CR1,CUBN,Cyp2d22,CYP39A1,DGAT1,EMX2,FAM111A,FAT4,FCGBP,FGL1,FLNC,GSTM3,H2BC21,IFI44,ITGB3,KIFC1,KMT5A,L1CAM,LGMN,LRP6,MAPK4,MEGF10,MMRN1,NCAN,PGK1,PLG,PLIN2,PNLIP,POU3F3,RAB11A,REG1A,RRM2,RRP12,RSL24D1,SCARF1,SLC5A7,SOD3,SUSD2,SYT12,THSD4,TNFSF14,TPPP3,TRAF3IP2,TSG101,WRN,XPO7 58 (46) 43 etoposide,forskolin MSTN acetylcholine,MDM2,PDK1,SLC2A1 CASR G-protein coupled receptor 3 -0.762 8.20E-06 1.20E-03 ACHE,Akt,Ap1,APP,ATF4,CASP3,CASR,CD28,CEBPA,COP1,CTNNB1,CTNND1,DICER1,EIF4E,ERK,ERK1/2,ESR2,FADD,FYN,GABBR1,HNF4A,HRAS,IFNAR1,IGF1,IL1B,IL2,Inflammasome (Nalp3, Asc, Casp1),IRF3,Jnk,JUN,MAPK1,MAPK3,MAPK8,MITF,MYB,NEDD9,NGEF,PIK3R1,PLC,PPARGC1A,PRKCE,PRKD2,Ras homolog,RB1,RICTOR,RUNX3,RXRA,SMAD2,SNCA,SRC,STAT5B,TAFAZZIN,TCF7L2,TGFB1,TNF,VDR,WBP2,WWOX ACAA1,ADGRG6,ADRM1,AIMP2,ANGPT2,ANGPTL3,ANOS1,AOC1,ATL2,B4GALT1,CALM1 (includes others),CALML3,CD209,CEBPD,CGAS,CHAC1,CHRNB3,CLEC10A,CUBN,DGAT1,EMILIN2,EMX2,ETNK1,FASN,FLNC,FUT6,IFI44,KIFC1,KMT5A,L1CAM,LRP5,MAPK4,MEGF10,MEGF11,MMRN1,NLGN2,PGK1,PIF1,PLG,PLIN2,POLI,PPP1CA,PTGIR,PTPRK,RRM2,RRP12,RSL24D1,SCARF1,SLC5A7,SUSD2,SVEP1,SYT12,TENM3,THSD4,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM2,TRIM3,TRIM56,TULP4 62 (58) 48 cocaine,denatonium benzoate,tunicamycin BMP7,CASP3,CCND2,CXCL10,CYP2B6,KIF22,PPP1CA,PRKD2,PTTG1,RAPGEF1,S100A9 CISH,SOCS3 sorbitol chemical - endogenous mammalian 3 -0.351 1.03E-05 2.80E-03 ACHE,AGT,Akt,AKT1,AMPK,Ap1,APP,CASP3,CDKN2A,CHRNA7,CXCL8,DICER1,EGFR,ERK,ERK1/2,ESR2,FADD,FOS,HIPK2,HSPB1,IFNGR1,IGF1,IL10,IL1B,IL2,IL6ST,IRF3,JAK1,Jnk,JUN,MAP2K6,MAP2K7,MAP3K1,MAP3K7,Map3k7,MAPK1,MAPK14,MAPK3,MAPK7,MAPK8,MAPK9,MAPKAPK2,MKNK1,MLXIPL,MYOD1,NFkB (complex),NFKBIA,NRAS,P38 MAPK,PAWR,PDPK1,PI3K (complex),PPP3R1,PRKAA1,PRKAA2,PRKCE,PTK2B,RICTOR,S100A9,SNCA,sorbitol,SOX2,SPARC,TFRC,TNF,TNFSF11,TP53,TREM2 ABCA5,ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,ARL6IP4,ATL2,B4GALT1,BCHE,C1QL1,CALCRL,CALM1 (includes others),CASP2,CD209,CELSR1,CHAC1,CHRNA10,CHRNB3,CLEC10A,CR1,CSMD3,DGAT1,DUT,ETNK1,FAM111A,FLNC,FRRS1,GLB1,GNAO1,GSTM3,H2BC21,HNRNPM,HSD3B2,ITGB3,KIFC1,L1CAM,Lgals6,LRP4,LRP5,LRP6,MATR3,MEGF11,NCAN,NUBP1,PLIN2,POLI,POU3F3,PPP1CA,PTGIR,PTK7,PTPRK,RAB11A,RRP12,RSL24D1,SLC5A7,SNAP25,SSPOP,THSD4,TKFC,TNFSF14,TNR,TNXB,TPPP3,TRAF3IP2,TRIM2,TRIM3,TRIM56,TSG101,VPS25,XPO7 73 (68) 53 SLC2A1 CASP3,Focal adhesion kinase,HSPB1,MAP3K11,Map3k7,MAP3K7,MAPK7,NFkB (complex),PRKAA1,Sapk,TAOK2 AKT1 FGR kinase -0.000 3 -0.882 1.13E-05 1.60E-03 26s Proteasome,ABL1,ACHE,Akt,AKT1,ALOX5,Alpha catenin,APP,CASP3,CASP8,CBL,COP1,DICER1,EIF4E,ERK1/2,ESR2,FADD,FGR,FOS,GAB2,HIPK2,HNF1A,HNF4A,HRAS,IFNAR1,IKZF1,IKZF3,IL10,IL1B,IL6ST,IRF3,Jnk,LAT,MAPK1,MAPK14,MAPK3,MAPK8,MITF,MYC,MYOD1,NEDD9,NGEF,NRAS,PAWR,PDPK1,PGR,PI3K (complex),PPARGC1A,RAF1,REL,RICTOR,RIPK2,S100A9,SIRT1,SNCA,SOS1,SOX2,SPARC,STAT3,SYK,SYK/ZAP,TNF,TNFSF11,VAV1 ADRM1,AGA,AIMP2,ANGPT2,ANOS1,AOC1,B4GALT1,BCHE,BIRC2,C1QL1,C1QTNF3,CD209,CGAS,CHAC1,CLEC10A,CR1,DGAT1,EMILIN2,ETNK1,FASN,FGL1,FLNC,FRRS1,FUT6,GSTM3,HCRTR2,HNRNPM,IFI44,ITGB3,L1CAM,Lgals6,LRP4,LRP5,LRP6,MATR3,MEGF11,NLGN2,NUBP1,PGK1,PIF1,PKD1L2,PTPRK,RAB11A,RRM2,RRP12,RSL24D1,SCARF1,SLC16A7,SLC5A7,SNAP25,SVEP1,SYT12,TENM3,THSD4,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM2,TRIM3,TRIM56,VPS25,XPO7 63 (64) 53 phytohemagglutinin miR-128-3p (and other miRNAs w/seed CACAGUG) LCP2,PGR,VAV1 AKT1,CASP3 infliximab biologic drug 3 0.342 1.21E-05 1.05E-02 26s Proteasome,AGT,Akt,AKT1,APP,AR,BCL2,CD40,CDK2,CDK5,CEBPB,COPS5,CREB1,CTNNB1,CYP1A1,EGF,EGFR,EIF2AK3,EIF4E,ERK1/2,FOS,FOXP3,Hdac,HIF1A,HSF1,IGF1,IL6,IL6ST,infliximab,INSR,IRF3,MAPT,Mmp,NFkB (complex),NFKB2,P38 MAPK,PDPK1,PPARD,PPARGC1A,PRKCE,PTEN,PTPN11,RAF1,RB1,REL,RUNX1,SP1,SREBF1,TERT,TNF,TNFSF11,TP53 ABCA3,ADGRG6,ADRM1,AGA,AIMP2,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,ASPG,ATL2,B4GALT1,BIRC2,BIRC3,C1QTNF3,CACHD1,CASP2,CD209,CEBPD,CELSR1,CGAS,CHRNB3,CR1,CSMD3,Cyp2d22,CYP39A1,EMILIN2,EMX2,FASN,FAT4,FCGBP,FGL1,FRRS1,GLB1,GSTM3,H2BC21,HNRNPM,HSD3B2,ITGB3,KIFC1,KRT8,LGMN,LITAF,LRP4,LRP6,MAPK4,MATR3,MGAT4C,NCAN,NLGN2,NUBP1,PLG,PLIN2,PNLIP,POU3F3,PPP1CA,RAB11A,REG1A,RRM2,RRP12,SERINC2,SLC16A4,SLC16A7,SLC5A7,SNAP25,SSPOP,SUSD2,SVEP1,TMPRSS6,TNFSF14,TNR,TNXB,TPPP3,TRIM56,TSG101,WRN 77 (52) 50 CCND2,ceramide,CYP27B1,prostaglandin E2,SPHK1,TRAF1,WNT3A NOX4 enzyme 3 -0.122 1.24E-05 2.10E-03 26s Proteasome,AKT1,ALK,Alpha catenin,APP,ARNTL,ATF4,CDK1,CDKN1B,COP1,EIF2A,EIF2AK3,EPAS1,ERK,ERK1/2,ESR2,ETS2,FADD,FGFR2,FMR1,GLI1,GRIN3A,HIF1A,HRAS,IFNAR1,IGF1,IL10,INSR,Jnk,Mapk,MAPK1,MAPK3,mir-21,MITF,MYB,NEDD9,NFE2L2,NOX4,NR1I3,P38 MAPK,PAWR,PDPK1,PGR,PKD1,PPARA,PPARGC1A,PRKCE,PTK,PTPN1,RB1,RICTOR,RPS6KB1,RUNX3,S100A9,SIRT1,SNCA,SOX2,SPARC,SRC,STAT3,STAT5B,STK11,TNF,TNFSF11,TSC1,WBP2,WWOX ADGRG6,ADRM1,AGA,ANGPT2,ANK1,AOC1,ATL2,B4GALT1,BCHE,BIRC2,BIRC3,C1QL1,C1QTNF3,CALCRL,CD209,CELSR1,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,CUBN,CYP39A1,DGAT1,EMILIN2,ETNK1,FCGBP,FLNC,FRRS1,GSTM3,H2BC21,HCRTR2,HNRNPM,HSD3B2,IFI44,L1CAM,LRP4,MAPK4,MATR3,MEGF11,MKX,PGK1,PIF1,PLG,PLIN2,PNLIP,POU3F3,PTPRK,RAB11A,RRM2,RRP12,RSL24D1,SLC16A4,SLC5A7,SOD3,SVEP1,SYCE2,SYT12,TENM3,THSD4,TMPRSS6,TPPP3,TRIM2,TRIM3,TRIM56,TULP4 67 (67) 60 avexitide,carbon monoxide,ERN1,HNF4A,leukotriene B4,PAK2,PLA2G6,SATB2,SOST 3-deazaneplanocin,BTG2,CBLC,CDKN2A,mefunidone,zoledronic acid EPAS1,GSTA1,HAS2,PDK1,radical,RPS6KB1,SLC2A1,TJP1 KIT,TFAM denatonium benzoate chemical drug 3 -0.365 1.27E-05 4.00E-04 Akt,Ap1,CASR,CHUK,CTNNB1,denatonium benzoate,ERK,ERK1/2,GNAT1,IKBKB,Jnk,JUN,MAPK1,MAPK3,MAPK8,SRC,TWIST1 ACAA1,ADGRG6,AIMP2,ANGPT2,AOC1,B4GALT1,CALM1 (includes others),CD209,CELSR1,CLEC10A,DGAT1,EMX2,FASN,FAT4,FCGBP,FLNC,IFI44,KIFC1,KRT8,L1CAM,PGK1,PLG,PLIN2,POLI,PPP1CA,PTPRK,RRM2,SOD3,SUSD2,TNFSF14 30 (17) 15 Ca2+,CASR EIF2AK1 kinase -0.000 3 0.283 1.32E-05 2.60E-03 AHR,Akt,AKT1,Ap1,ATF4,CDKN1B,CEBPA,CSF2,CXCL8,cytokine,EIF2A,EIF2AK1,EIF2S1,ERK,estrogen receptor,HIF1A,HNF4A,IL1B,IL6,IRF3,JUN,MTORC1,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,PAX6,POU2F2,REL,RICTOR,SMAD3,STAT1,STAT4,STAT5A,VAMP8 ABCA3,ADGRG6,AGA,AIMP2,ALDH7A1,ANGPT2,ANGPTL3,ANOS1,AOC1,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALM1 (includes others),CD209,CEBPD,CHAC1,CLEC10A,CLPB,CR1,Cyp2d22,CYP39A1,EMILIN2,FASN,FAT4,FGL1,FLNC,FUT6,GNAO1,GSTM3,H2BC21,HNRNPM,HSD3B2,IFI44,LITAF,LRP6,MATR3,MMRN1,NCAN,PGK1,POLI,PTPRK,RAB11A,RSL24D1,SLC16A4,SOD3,SYT12,TMPRSS6,TNFSF14,TRAF3IP2 50 (36) 33 DETA-NONOate,Hsp90 GnRH-A NFkB (complex) iron 4-phenylbutyric acid chemical - endogenous mammalian 3 -0.239 1.35E-05 3.00E-03 4-phenylbutyric acid,ACOX1,Akt,AKT1,APP,ATF4,CASP3,CAT,CDKN1B,CDKN2A,CEBPA,cisplatin,COP1,CREB1,CYP1B1,cytarabine,decitabine,DICER1,DLX5,DNMT3B,doxorubicin,EIF2A,EIF2AK3,etoposide,ETS2,FADD,Hdac,HDAC2,HDAC3,HDAC4,HDAC5,HDAC7,HIPK2,HNF4A,hydrogen peroxide,IFNAR1,IGF1,Jnk,KLF3,KRT8,MAPK8,mir-21,MITF,MYB,MYOD1,NGEF,NOS3,P38 MAPK,p70 S6k,PDPK1,POR,PPARGC1A,PRKAA,RICTOR,S100A9,SOX2,SPARC,STAT3,STING1,TGFB1,TNF,TNFSF11,topotecan,TSC1,WWOX ABCA3,ACAA1,ADRM1,AGA,AIMP2,ANGPT2,ANK1,ATL2,B4GALT1,BCHE,C1QL1,CACHD1,CALML3,CASP2,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,DGAT1,EMILIN2,EMX2,ETNK1,FAM111A,FGL1,FRRS1,FUT6,GLB1,GSTM3,HNRNPM,ITGB3,KMT5A,Lgals6,LRP4,LRP5,LRP6,MATR3,MEGF10,MEGF6,MGAT4C,MKX,MMRN1,PGK1,PIF1,PLIN2,PNLIP,POU3F3,PPP1CA,PRKCSH,PTPRG,PTPRK,RAB11A,REG1A,RRM2,RSL24D1,SCARF1,SLC16A4,SOD3,SUSD2,SVEP1,SYT12,TKFC,TNFSF14,TNR,TPPP3,TRIM2,TRIM36,TRIM56,TULP4,XPO7 70 (65) 54 AKT1,CAMP,EHHADH,etoposide,MOG,SOCS3,TJP1,VAMP7 CASP3,ERN1,leucine RPSA translation regulator 0.000 3 1.250 1.47E-05 2.70E-03 APP,CDKN1B,CEBPA,Creb,CREB1,CTNNB1,CYP19A1,EGFR,EIF2AK3,EIF4E,ERK,ERK1/2,ESR1,ETS2,FADD,FOS,HIF1A,HNF1A,HNF4A,HRAS,IFNAR1,IGF1,IL10,IRF3,ITGB1,Jnk,JUN,KRT8,MAPK14,MAPK8,MAPT,MITF,MYB,MYOD1,NFATC2,NFKB2,NFKBIA,P38 MAPK,PDPK1,PGR,PP2A,PPARA,PPARGC1A,RB1,REL,RHOA,RICTOR,RPSA,RXRA,S100A9,SIRT1,STK11,TNF,TWIST1 ADGRG6,AGA,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ASPG,ATL2,B4GALT1,BBX,BCHE,C1QTNF3,CD209,CEBPD,CGAS,CLEC10A,CLPB,CR1,DGAT1,DPY19L3,EMILIN2,ETNK1,FASN,FAT4,FGL1,FUT6,GSTM3,HCRTR2,ITGB3,KRT8,Lgals6,LITAF,LRP6,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NCAN,NLGN2,NUBP1,PIF1,PKD1L2,PNLIP,POLI,POU3F3,RAB11A,REG1A,RSL24D1,SERINC2,SLC16A4,SOD3,SUSD2,SVEP1,TENM3,THSD4,TMPRSS6,TNR,TNXB,TPPP3,TRIM56,TRPM2,TULP4 64 (54) 51 FASLG CASP3,DUSP2,TAP1,TRAF1 suramin chemical drug 3 0.000 1.57E-05 3.20E-03 AGT,AHR,Akt,AKT1,APP,CARM1,CDC25A,CDKN1B,CITED2,COP1,CYP1B1,doxorubicin,E2F3,EGFR,EIF2AK3,ERK1/2,ETS2,FADD,FHIT,FOS,FSHR,HOXA10,IFNAR1,IFNGR1,IGF1,IL1B,IL6ST,INSR,JAK2,MAPK1,MAPK3,mir-21,MITF,mitomycin C,NEDD9,NFATC2,NFkB (complex),NFKB2,NGEF,NRAS,P38 MAPK,PI3K (complex),PRKCZ,PRMT1,PTPN1,RELA,S100A9,SIRT1,SMAD3,SMARCA4,SOX2,SPARC,STAT3,suramin,TGFB1,TNFSF11,Trk Receptor,VDR ABCA3,AIMP2,AKNA,ALDH7A1,ANGPT2,ANK1,AOC1,ARL6IP4,ATL2,B4GALT1,BBX,BCHE,BIRC2,C1QL1,C1QTNF3,CACHD1,CALML3,CASP2,CD209,CEBPD,CGAS,CLEC10A,CLPB,CUBN,DGAT1,ETNK1,FCGBP,FLNC,FRRS1,GLB1,GSTM3,HCRTR2,HNRNPM,HSD3B2,IFI44,ITGB3,KMT5A,KRT8,L1CAM,LGMN,LRP4,LRP5,MATR3,MKX,NUBP1,PGK1,PIF1,PLG,PNLIP,RAB11A,RRM2,SCARF1,SOD3,SSPOP,SYT12,THSD4,TNFSF14,TNR,TNXB,TPPP3,TRAF3IP2,TRIM2,TRIM36,TSG101,TULP4,VPS25 66 (58) 51 HMOX1,mitomycin C AKT1,Ca2+,CASP3,caspase,CDH2,MSTN,NFkB (complex),prostaglandin E2 benzo(a)pyrene chemical toxicant 3 -1.068 1.62E-05 5.10E-03 2-amino-1-methyl-6-phenylimidazo-4-5-b-pyridine,26s Proteasome,ACHE,AHR,Akt,APP,benzo(a)pyrene,BHLHE40,CASP3,CASP8,CAT,CDK1,CDKN2A,clopidogrel,CREB1,CXCL8,CYP,CYP1A1,CYP1B1,DICER1,DLX5,EIF2AK3,EIF4E,ERK,ERK1/2,ESR2,ETS2,FADD,FOS,GLI1,HNF4A,HRAS,hydrogen peroxide,IL10,IL1B,IL22,Jnk,JUN,MAP2K4,MAPK8,MYB,MYOD1,NFATC2,NFkB (complex),NFKB2,NGEF,Nos,PPARA,PPARGC1A,PRKCE,PTPRJ,RAC1,RICTOR,RXRA,SIRT1,SOX2,TCF7L2,TGFB1,TNF,TP53 ADGRG6,ADRM1,AIMP2,ALDH7A1,ANGPT2,ANGPTL3,ANK1,AOC1,B4GALT1,BBX,BIRC3,C1QL1,C1QTNF3,CACHD1,CALCRL,CALML3,CASP2,CD209,CEBPD,CELSR1,CHAC1,CHRNB3,CLEC10A,CR1,CSMD3,DGAT1,DUT,EMILIN2,ETNK1,FAM111A,FASN,FUT6,GLB1,GNAO1,GSTM3,HCRTR2,ITGB3,KIFC1,KMT5A,L1CAM,Lgals6,LRP4,LRP5,MEGF10,MGAT4C,MKX,NANOS1,NLGN2,NUBP1,PNLIP,POLI,POU3F3,PPP1CA,PRKCSH,RAB11A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC5A7,SOD3,SVEP1,SYT12,TENM3,THSD4,TNFSF14,TPPP3,TRAF3IP2,TRIM56,TSG101 71 (60) 53 beta-naphthoflavone ALDH3A1,Ca2+,CASP3,caspase,FGF9,Hsp90,IGFBP6,MDM2,NFkB (complex),NMI,SOD3,XPC CKS1B,FGFR3,GSTA1,ITPR1,NQO2,PDCD6,PDLIM1 BMS-906024 chemical drug 3 1.633 1.65E-05 5.00E-04 Akt,AKT1,BMS-906024,MAPK14,MAPK8,MDM2,Notch,NOTCH1,NOTCH3,PI3K (complex),PSEN1,PSEN2,Secretase gamma,TREM2 AIMP2,B4GALT1,BIRC2,BIRC3,CASP2,CLEC10A,DGAT1,FASN,H2BC21,HNRNPM,ITGB3,KRT8,L1CAM,LRP6,MATR3,PGK1,PLG,PTK7,PTPRK,RRM2,TNFSF14,TNXB,TSG101,WRN 24 (14) 12 Notch,Secretase gamma HNF4A transcription regulator 0.000 3 -1.291 1.69E-05 5.10E-03 2-amino-1-methyl-6-phenylimidazo-4-5-b-pyridine,AHR,ATR,CAT,CEBPA,clopidogrel,Creb,CREBBP,CTNNB1,CXCL8,CYP1A2,CYP2B6,CYP7A1,EGFR,ESR2,FOXA1,glutathione peroxidase,GSTK1,HIF1A,HMOX1,HNF1A,HNF4A,hydrogen peroxide,IL1B,IL6,INSR,IRF3,JUN,MAPT,MYB,MYOD1,NFkB (complex),NFKBIA,POU2F2,PTPRJ,RB1,REL,SOX2,STAT,TCF4,TCF7L2,transcription factor,VDR ACAA1,AGA,ALDH7A1,ANGPT2,ANGPTL3,ANOS1,ASPG,B4GALT1,BBX,BIRC2,BIRC3,C1QL1,CACHD1,CEBPD,CGAS,CHAC1,CR1,CUBN,DPY19L3,EMILIN2,EMX2,FAM111A,FASN,FCGBP,FGL1,FUT6,GSTM3,H2BC21,ITGB3,KIFC1,KMT5A,L1CAM,Lgals6,LITAF,LRP4,MEGF10,NANOS1,NCAN,PGK1,PKD1L2,PLG,PLIN2,POLI,PRKCSH,RAB11A,REG1A,RRP12,SLC16A4,SLC5A7,SOD3,SUSD2,SYT12,TMPRSS6,TNFSF14,TNR,TNXB,TRAF3IP2,TRIM2,TRPM2,TULP4 60 (43) 38 CNN1,EP300 CDN1163,JINK1/2,LRP5,NR0B1 ACSL1,ACSS2,AHNAK,ATOX1,ATP7A,Ca2+,CIDEC,CYP2B6,G6PC3,GSTA1,HMOX1,LOC102724788/PRODH,mir-154,Mt,NOX4,SCP2,SOD1,TAT,urea BMP7,deoxycholate,leukotriene B4,miR-142-5p (and other miRNAs w/seed AUAAAGU),Mt3,PDK1,POR,SLC2A1 PPARD ligand-dependent nuclear receptor 0.000 3 1.152 1.70E-05 3.80E-03 26s Proteasome,ABCB4,ACHE,AHR,Akt,AKT1,Alpha catenin,AMPK,ATF4,CASP3,CTNNB1,DICER1,DOCK8,EIF2AK3,EIF4E,ELAVL1,ERK1/2,ESR2,FOXO1,GSK3B,HIPK2,IL1B,IL2,IL6,KLF6,LGALS3,MAP2K1/2,MAP3K7,MITF,MLXIPL,MYOD1,NFATC2,NFkB (complex),NFKB2,NFKBIA,NGEF,PAK2,PAWR,PDPK1,PPARA,PPARD,PPARG,PRKAA,PRKCA,progesterone,RAF1,SIRT1,SOX2,SPARC,STAT3,TNFSF11,VDR ACAA1,ADRM1,AIMP2,ALDH7A1,ANGPTL3,AOC1,B4GALT1,BBX,C1QL1,C1QTNF3,CACHD1,CASP2,CD209,CEBPD,CGAS,CHAC1,CLEC10A,CUBN,CYP39A1,DGAT1,EMX2,FAM111A,FCGBP,FGL1,FRRS1,GSTM3,HCRTR2,HNRNPM,ITGB3,KIFC1,KRT8,Lgals6,LITAF,LRP4,LRP5,MATR3,NCAN,NLGN2,PGK1,PIF1,PLIN2,PNLIP,PRKCSH,PTGIR,RAB11A,RRP12,SCARF1,SERINC2,SLC16A7,SLC5A7,SOD3,SUSD2,SYT12,TKFC,TNFSF14,TNR,TRAF3IP2,TRIM2,TSG101,WRN,XPO7 61 (52) 45 12(S)-hydroxyeicosatetraenoic acid,8(S)-hydroxyeicosatetraenoic acid,8-bromo-cAMP,anandamide,delta-tocotrienol,linsidomine,PD173074,prostaglandin A1,prostaglandin A2 indomethacin,N-cor,NCOA3,PLCL1 AKT1,CCNE1,CYP2B6,MAP3K7,MDFI,MERTK,MOG,NFkB (complex),oleic acid,PAK2,PDK1,RASGRP1,RBP1 ANGPTL4,CASP3,CCL3L3,CCND2,CLEC7A,GPAM,IGFBP6,IgG,Irgm1,NPY,TFF2,VLDL Hsp90 group 3 0.000 1.80E-05 9.60E-03 26s Proteasome,AHR,Akt,APP,ATF3,CD24,CDKN1B,CDKN2A,CHRNA7,CREB1,CYP1A1,doxorubicin,EIF2AK2,EIF2AK3,EIF4E,ERBB2,ERK,ERK1/2,ESR2,estrogen receptor,FGFR2,FGFR3,geldanamycin,GLI1,HRAS,HSF1,Hsp90,HSP90AB1,IGF1,IL10,IL10RA,IL1B,IL22,IL6,IRF3,Jnk,KDM3A,KRT8,lipopolysaccharide,MAP3K5,MAPT,mir-21,MYB,MYOD1,Nfat (family),NOS3,NR1I2,P38 MAPK,PDPK1,PGR,PP2A,PPARA,PRMT1,RAF1,REL,RICTOR,S100A9,SIRT1,SMAD3,SMARCA4,STAT1,STAT3,STK11,TGFB1,TLR2,TLR4,TNF,TP53,TRAF3IP2,TSSK4,TWIST1 ACAA1,ADGRG6,ADRM1,AGA,AIMP2,ANGPT2,ANK1,ANOS1,AOC1,ASPG,ATL2,B4GALT1,BCHE,C1QTNF3,CACHD1,CALCRL,CALML3,CASP2,CD209,CHRNA10,CLEC10A,CLPB,CR1,CSMD3,CYP39A1,DGAT1,DPY19L3,EMILIN2,FAM111A,FAT4,FGL1,FLNC,GLB1,GNAO1,GSTM3,HCRTR2,HSD3B2,ITGB3,KIFC1,KMT5A,L1CAM,Lgals6,LRP5,MAPK4,MEGF10,MGAT4C,NLGN2,PGK1,PLG,PLIN2,PNLIP,POLI,PPP1CA,PTPRG,PTPRK,RAB11A,REG1A,RRP12,RSL24D1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SNAP25,SNX33,SOD3,SYT12,TENM3,THSD4,TNFSF14,TNR,TNXB,TPPP3,TRAF3IP2,TRIM2,TRIM3,TRIM36,TRIM56,TSG101,TULP4 80 (71) 61 benzo(a)pyrene,carmustine,hydrogen sulfide,lactacystin,prostaglandin A1,riluzole caffeic acid phenethyl ester,quercetin,retaspimycin,S-adenosylmethionine,tanespimycin AKT1,CCND2,EIF2AK1,EPAS1,ESR2,FGFR3,Focal adhesion kinase,KDM3A,KIR2DS2 (includes others),MAP3K7 ATR,PGR,PPARA,radical miR-127 prodrug chemical reagent 1 1.732 1.83E-05 2.00E-04 miR-127 prodrug FASN,NANOS1,SUSD2 3 (1) 1 deferoxamine chemical drug 3 -1.650 1.88E-05 4.90E-03 ACHE,AHR,AKT1,antioxidant,APP,BHLHE40,CASP3,CAT,CDKN1B,CDKN2A,CTNNB1,deferoxamine,DICER1,DIO2,EIF2AK3,ERBB2,ERK,ERK1/2,ESR2,ETS2,FADD,GRIN3A,HIF1A,HRAS,hydrogen peroxide,IGF1,IL6,JINK1/2,Jnk,KRT8,MAPT,MMP2,Nfat (family),NFATC2,NFkB (complex),NR1I2,NRAS,P38 MAPK,PAWR,PGR,PI3K (complex),PPARA,PPARGC1A,PRKCE,PRKRA,PTPRJ,REL,RELA,RICTOR,S100A9,Sapk,SIRT1,SNCA,SOX2,SRC,STING1,TCF7L2,TNF,TNFSF11,TP53,TWIST1,VDR ACAA1,ADGRG6,AGA,ALDH7A1,ANGPT2,ANK1,AOC1,ASPG,ATL2,B4GALT1,BBX,BCHE,C1QL1,CALCRL,CASP2,CD209,CELSR1,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CSMD3,CUBN,DPY19L3,DUT,EMILIN2,EMX2,ETNK1,FAM111A,FASN,FAT4,FGL1,FRRS1,GLB1,GSTM3,HCRTR2,HNRNPM,ITGB3,KIFC1,KMT5A,LRP4,LRP5,MATR3,MEGF11,MKX,PGK1,PLG,PLIN2,PNLIP,POLI,POU3F3,PRKCSH,PTPRK,REG1A,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC5A7,SOD3,SUSD2,SYCE2,TENM3,THSD4,TMPRSS6,TNFSF14,TRIM3,TRIM56,TSG101,VPS25 72 (62) 55 AKT1,ANGPT4,ANGPTL4,ATF2,BHLHE40,CAMP,CCL3L3,CCNE1,CCR7,DIO2,DUSP16,EPAS1,HMOX1,IRS1,JINK1/2,KIT,MDM2,PIP5K1B,Sapk,SLC2A1,SOST,SULF2 CASP3,CCND2,CDKN2A,FASLG,iron,MFN2,NFkB (complex),SLC5A5,TAOK2 angustibalin chemical - endogenous non-mammalian 3 -0.263 1.93E-05 8.40E-03 AHR,Akt,angustibalin,Ap1,CCND1,CEBPA,CEBPB,CSF2,CXCL8,CYP19A1,cytokine,estrogen receptor,HIF1A,HNF4A,IKBKB,IL1B,IL6,INSR,IRF3,JUN,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,POU2F2,PRKCE,REL,SMAD3,SP1,STAT1,STAT4,TP53,VitaminD3-VDR-RXR ABCA3,AGA,AIMP2,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,ASPG,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CHRNB3,CLEC10A,CR1,CSMD3,Cyp2d22,CYP39A1,DUT,EMILIN2,FCGBP,FGL1,FLNC,FUT6,GLB1,GNAO1,GSTM3,H2BC21,IFI44,ITGB3,KIFC1,L1CAM,LGMN,LITAF,LRP5,LRP6,MMRN1,NCAN,PGK1,PLG,POLI,PPP1CA,PTPRK,REG1A,RRM2,SLC16A4,SOD3,SYT12,TMPRSS6,TNFSF14,TRAF3IP2,TSG101 58 (34) 33 NFkB (complex) phospholipid chemical - endogenous mammalian 3 1.969 2.27E-05 2.30E-03 26s Proteasome,ABCB4,AHR,Akt,AKT1,ANXA7,CAPN1,CDKN1B,CXCL8,EIF4E,ELAVL1,ESR1,ETS2,F3,F7,FADD,FGFR2,FMR1,FOS,Gpcr,GSK3B,HNF4A,HRAS,IL1B,IL6,INSR,IRF3,KLF6,LGALS3,MGAT1,MITF,NFkB (complex),NFKB2,NGEF,NRAS,PAK2,PDPK1,phospholipid,Pkc(s),PKN1,PPARA,PPARGC1A,PRKCE,PRKCZ,PRKD1,PROC,REL,RGS4,RICTOR,RPS6KB1,RXFP2,S100A8,S100A9,SNCA,SNCB,SOX2,SPARC,SYN1,TNF,TNFSF11,TOP1,TWIST1 ACAA1,ADRM1,AGA,AIMP2,ALDH7A1,ANGPT2,ANOS1,B4GALT1,BCHE,C1QL1,C1QTNF3,CACHD1,CASP2,CGAS,CHAC1,CHRNB3,CLPB,CR1,DGAT1,ETNK1,FASN,FAT4,FCGBP,FGL1,FRRS1,FUT6,GLB1,GSTM3,HNRNPM,HSD3B2,ITGB3,KRT8,L1CAM,LRP5,MATR3,MEGF11,MEGF6,MKX,NLGN2,NUBP1,PIF1,PLG,PLIN2,PRKCSH,RAB11A,REG1A,RRM2,RSL24D1,SCARF1,SERINC2,SOD3,SSPOP,SVEP1,SYCE2,SYT12,TENM3,TNFSF14,TRAF3IP2,TRIM2,TRIM3,TRIM56,TRPM2,TSG101,TULP4,VPS25,WRN 66 (62) 51 PTN,S-adenosylmethionine oleic acid,SAA,SAA1,SCP2,TFPI AKT1,CCL3L3,CXCL10,F10,leukotriene B4,PAK2,PKN2,PTAFR,RPS6KB1 NFkB (complex) complex 3 0.000 2.27E-05 1.04E-02 26s Proteasome,AHR,Ap1,APP,BCL2,BHLHE40,CCND1,CD24,CEBPA,CREB1,CSF2,CXCL8,CYP1A1,CYP1A2,cytokine,E2F3,EIF4E,ELAVL1,ESR2,estrogen receptor,FOXA1,GJA1,HIF1A,HNF1A,HNF4A,hydrogen peroxide,ICAM1,IFNG,IGF1,IKBKB,IL1B,IL6,IL6ST,INSR,IRF3,JUN,KMT2A,L-triiodothyronine,MAPK8,MITF,NFATC2,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,NRAS,POU2F2,PPARG,PPARα-RXRα,PPIF,PRKCD,PXR ligand-PXR-Retinoic acid-RXRα,REL,Retinoic acid-RAR-RXR,RICTOR,SIRT1,SMAD3,SP1,STAT1,STAT4,STAT5A,tetradecanoylphorbol acetate,TNF,TP53,tretinoin,VDR ABCA3,ACAA1,ADRM1,AGA,AKNA,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,ATL2,B4GALT1,BBX,BIRC2,BIRC3,C1QTNF3,CACHD1,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CHAC1,CLEC10A,CR1,CSMD3,CUBN,Cyp2d22,CYP39A1,EMILIN2,FCGBP,Fcna,FGL1,FLNC,FUT6,GLB1,GNAO1,GSTM3,H2AC21,H2BC21,HCRTR2,HSD3B2,IFI44,ITGB3,KIFC1,L1CAM,LITAF,LRP6,MEGF10,MGAT4C,MKX,MMRN1,NCAN,NLGN2,PGK1,PIF1,PKD1L2,POLI,POU3F3,PPP1CA,PRKCSH,PTPRG,PTPRK,REG1A,RRP12,RSL24D1,SCARF1,SLC16A4,SLC5A7,SOD3,SSPOP,SYCE2,SYT12,TMPRSS6,TNR,TPPP3,TRAF3IP2,TRIM2,TRIM56,TSG101,TULP4,VPS25 82 (67) 60 1-methyl-4-phenylpyridinium,12(S)-hydroxyeicosatetraenoic acid,3-methyladenine,6-hydroxydopamine,AGAP2,AKT1,apicularen A,aplidine,benzo(a)pyrene,Ca2+,CALM1 (includes others),camptothecin,carbon monoxide,carbon tetrachloride,ceramide,Ck2 alpha,CLEC7A,daunorubicin,deoxycholate,doxycycline,EIF2AK1,EP300,ERN1,etoposide,fatty acid,Fc gamma receptor,G protein,G protein beta gamma,ganglioside,IgG,INS,irinotecan,IRS1,isatin,lauric acid,LCP2,leukotriene B4,LRRFIP1,MALP-2s,Map3k7,MAP3K7,MAPK7,MEOX2,MOG,MRAS,N-acetylmuramyl-L-alanyl-D-isoglutamine,NOX1,NQO2,NTRK1,ouabain,p85 (pik3r),Pak,Pam3-Cys,paraquat,PDLIM1,peptidoglycan,peroxynitrite,phytohemagglutinin,PIK3CG,PPARD,prednisolone,PRKD2,PRNP,PTAFR,radical,RPS6KA4,RRM2,S100A9,SDCBP,SENP6,sorbitol,SPHK1,ST14,tacrolimus,TACSTD2,TAT,TIRAP,TNFRSF11A,TP53BP2,TRPC4AP,tyrosine kinase,USP2,USPL1,VAV1,WNT1,WNT5A,XDH,YES1 1'-acetoxychavicol acetate,14,15-epoxyeicosatrienoic acid,3-hydroxyanthranilic acid,angustibalin,ANXA4,arginine,ASCC1,ATR,bisindolylmaleimide II,caffeic acid phenethyl ester,capsazepine,CARD8,CDKN2A,cerivastatin,chondroitin sulfate E,CHP1,CISH,CYP27B1,DAB2IP,deferoxamine,dehydroxymethylepoxyquinomicin,DETA-NONOate,ellagic acid,epicatechin,ESR2,evodiamine,FAF1,FANCC,forskolin,gambogic acid,glabridin,GPAM,indirubin,indole-3-carbinol,indomethacin,IRAK3,KU-55933,L-triiodothyronine,LG100268,LHB,lonafarnib,N,N-dimethylsphingosine,naproxen,nimbolide,NLRX1,noscapine,oleic acid,PD 123319,PELI3,PGR,piceatannol,PIK3CA,PLC gamma,plumbagin,prostaglandin A1,prostaglandin A2,PS-K,quercetin,resiniferatoxin,RGS3,RNF41,rofecoxib,salinosporamide A,sanguinarine,SELENOS,SLC25A4,SOD1,suramin,tanespimycin,telmisartan,TFPI,tosylphenylalanyl chloromethyl ketone,TSC22D3,tunicamycin,USP18,USP19,Vhl,wogonin,xanthohumol,Z-YVAD-FMK,zerumbone,ZMYND11 ATF2,CAMP,CAV3,CCL7,CCND2,CCR7,CDX1,CLCF1,CX3CL1,CXCL10,CXCL9,DBP,DEFB103A/DEFB103B,EPAS1,FCGR1A,HAS2,HSPB1,IL27,KIT,MDM2,MSTN,MTSS1,SDC4,SLC2A1,SOCS3,SOD3,TAP1,TERT DIO1,iron,ITPR1,TRPC6 galanthamine chemical drug 3 -1.521 2.32E-05 1.20E-03 ACHE,Akt,Calcineurin protein(s),CHRNA4,CHRNA7,CHRNB2,Creb,CREB1,DUSP1,ERK,ERK1/2,galanthamine,GRIN3A,L-glutamic acid,MAPK1,MAPK14,MAPK8,Nfat (family),NFkB (complex),nicotinic acetylcholine receptor,NMDA Receptor,NRAS,NTRK2,P38 MAPK,Pkc(s),PRKCE,SRC,SRC (family) ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,BIRC2,CALCRL,CEBPD,CHRNA10,CHRNB3,CLEC10A,DGAT1,DPY19L3,FLNC,HCRTR2,IFI44,ITGB3,KRT8,L1CAM,LITAF,LRP6,MGAT4C,PGK1,PLG,PLIN2,PTPRK,SERINC2,SLC5A7,SNAP25,SOD3,TNFSF14,TSG101,TULP4,VPS25 35 (28) 23 acetylcholine,Ca2+,CHRNA4,NMDA Receptor ACHE farnesol chemical reagent 3 -0.882 2.44E-05 2.40E-03 ACHE,Akt,APP,AR,CASP3,CDK2,CEBPA,COP1,CREB1,DICER1,E2F3,EGFR,EIF4E,ERK,ERK1/2,ESR1,ESR2,ETS2,FADD,farnesol,FOS,HIF1A,HMOX1,HNF4A,HRAS,IGF1,IL10,INSR,IRF3,ITGB1,Jnk,KRT8,MITF,MYB,MYOD1,NFATC2,NGEF,NR1H4,NR1I2,NR1I3,NRAS,P38 MAPK,Pld,PPARA,PPARGC1A,RAS,RICTOR,Rxr,RXRA,S100A9,SIRT1,SMARCA4,SOX2,STK11,TNF,TWIST1 ADGRG6,AIMP2,AKNA,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ATL2,B4GALT1,BBX,BCHE,BIRC2,BIRC3,C1QL1,CD209,CEBPD,CLEC10A,CR1,Cyp2d22,CYP39A1,EMILIN2,ETNK1,FASN,FAT4,FCGBP,FUT6,HCRTR2,ITGB3,L1CAM,Lgals6,LRP5,MEGF10,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PIF1,PLG,REG1A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC5A7,SNAP25,SOD3,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TNXB,TPPP3,TRIM36,TRIM56,TRPM2,VPS25 63 (56) 52 ATF3,CASP3,PPARA Focal adhesion kinase group 3 -0.122 2.51E-05 6.10E-03 26s Proteasome,ACHE,Akt,Alpha catenin,APP,ATF4,BHLHE40,CASP8,CDKN1A,CDKN1B,CDKN2A,COP1,ERK,ERK1/2,ESR2,ETS2,FADD,Focal adhesion kinase,GJA1,GLI1,Hdac,HIF1A,HIPK2,IGF1,IL10,IL1B,IL6,Jnk,MAPK1,MAPK3,MAPK8,MDM2,NANOG,NEDD9,NGEF,NRAS,P38 MAPK,PI3K (complex),PKD1,PRKCE,PTK2,PTK2B,Rab5,RAC1,RAS,REL,RET,RGS4,RHOA,RICTOR,S100A9,SNCA,SRC,STING1,STK11,TCF7L2,tetradecanoylphorbol acetate,TNF,TP53,WBP2,WWOX ADGRG6,ADRM1,AGA,AIMP2,ANGPT2,ANK1,AOC1,ATL2,BCHE,BIRC2,BIRC3,C1QTNF3,CALCRL,CASP2,CD209,CELSR1,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,CSMD3,DGAT1,DUT,ETNK1,FAM111A,FASN,FGL1,FLNC,GLB1,H2BC21,IFI44,KIFC1,KMT5A,KRT8,L1CAM,LRP4,MEGF11,MEGF6,MKX,PGK1,PLG,PPP1CA,PTGIR,PTPRG,PTPRK,RRM2,RRP12,RSL24D1,SCARF1,SLC16A4,SLC5A7,SSPOP,SYT12,TMPRSS6,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM2,TRIM3,TRIM56,TSG101,VPS25,WRN,XPO7 67 (61) 51 12(S)-hydroxyeicosatetraenoic acid,AGAP2,AKT1,barium,CAMP,CDH17,chenodeoxycholic acid,Ecm,Fc receptor,FPR1,GAST,HAS2,Hsp90,IFT20,ITGA4,MAPK7,NCOA3,NRP2,oleic acid,peptidoglycan,prostaglandin E2,PTAFR,PTN,SDC4,SDCBP,sorbitol,sucrose Arg-Gly-Asp,DAB2,doxycycline,MEN1,MGAT3,MGAT5,MME,PF-573228,PIK3CA,PND-1186,RGMA,SOCS3,zoledronic acid CDH2,FASLG,Rab5 KRT18,MDM2 cytokine receptor group 3 -1.214 2.90E-05 1.90E-03 Alpha catenin,APP,CBL,CD40,CDKN1B,CREB1,CTNNB1,CXCR1,cytokine,cytokine receptor,EIF2AK3,EIF4E,ESR1,FADD,GRIN3A,Hdac,HIPK2,HNF4A,HOXA10,HRAS,IFNGR1,IKK (complex),IL10RA,IL1R1,IL2,IL2RA,IL2RB,IL4,IL4R,IL5RA,IL6,IL6R,IL6ST,IRF3,JAK,JAK2,Jnk,KRT8,MAPT,MDM2,MITF,NEDD9,NFKB2,NRAS,PGR,PIK3CA,PIK3CB,PIK3CD,PKD1,PPARGC1A,PRKCE,PTK2,RAS,RB1,REL,RICTOR,RXRA,SNCA,SOX4,SRC,SRC (family),STAT,TNF,TRAF2,TRAF6,TWIST1,WBP2,WWOX ADRM1,AGA,ANGPTL3,ANOS1,ARL6IP4,ASPG,B4GALT1,BCHE,BIRC2,BIRC3,C1QTNF3,CACHD1,CEBPD,CHAC1,CHRNB3,CLEC10A,CLPB,EMILIN2,ETNK1,FCGBP,FGL1,FUT6,GSTM3,H2BC21,HCRTR2,ITGB3,LRP4,MAPK4,MEGF11,MGAT4C,NLGN2,PGK1,PIF1,PLG,PNLIP,POU3F3,PTGIR,REG1A,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SUSD2,TENM3,THSD4,TNR,TPPP3,TRIM2,TRIM3,TRIM56,TRPM2,TULP4,VPS25,XPO7 55 (68) 53 LIF PIK3CA,PIK3CD CDK4/6 group 3 0.135 2.92E-05 3.40E-03 ACHE,Akt,AKT1,Ap1,APP,CDK2,CDK4,CDK4/6,CDK6,CDKN1A,CDKN1B,CDKN2A,CREB1,DLX5,E2F3,EGFR,EIF2AK3,EIF4EBP1,ESR1,ESR2,estrogen receptor,FOS,FOXM1,GLI1,GSK3B,INSR,IRF3,KLF6,LGALS3,MAPK1,MITF,MTOR,MYB,NGEF,NR1I2,p70 S6k,PDPK1,PPARGC1A,PSEN1,RB1,RBL2,RICTOR,SMARCA4,SOX2,TSC1,TWIST1,Vegf ADRM1,AGA,AIMP2,AKNA,ANGPT2,ANOS1,BIRC3,C1QL1,C1QTNF3,CALCRL,CALM1 (includes others),CEBPD,CELSR1,CLPB,CYP39A1,EMILIN2,FAM111A,FASN,FAT4,FCGBP,FLNC,GLB1,H2BC21,HNRNPM,ITGB3,KIFC1,L1CAM,LRP4,MAPK4,MATR3,MEGF10,MGAT4C,NUBP1,PGK1,PIF1,PLG,PNLIP,POU3F3,PRKCSH,RAB11A,RRM2,RRP12,RSL24D1,SCARF1,SLC5A7,SNAP25,SVEP1,THSD4,TNFSF14,TNR,TNXB,TPPP3,TRIM36,TRPM2,TULP4 55 (47) 45 CDKN2A AHNAK,NCOA3,RRM2 HSPB1,KRT10,LASP1 zoledronic acid chemical drug 3 0.585 2.95E-05 7.60E-03 AHR,Akt,AKT1,AR,BCL2,BHLHE40,CASP3,CASP8,CDKN2A,CEBPA,CREB1,CYP19A1,CYP1B1,DICER1,EIF2AK3,ERK,ERK1/2,ESR1,ETS2,FADD,Focal adhesion kinase,FOS,GLI1,GSK3B,Hdac,HIF1A,HNF4A,HRAS,IL1B,IL6,IRF3,LGALS3,MITF,MMP9,MYOD1,NFATC2,NGEF,NRAS,paclitaxel,PDPK1,PPIF,RAC1,RAF1,RAS,RELA,RHOA,SIRT1,SMAD3,SOX2,SPARC,STAT3,STAT5B,STING1,TCF7L2,TNF,TNFSF11,TP53,TWIST1,VDR,zoledronic acid ADGRG6,AIMP2,ANGPT2,ANK1,ANOS1,AOC1,ASPG,B4GALT1,BBX,BIRC2,BIRC3,C1QL1,C1QTNF3,CACHD1,CALCRL,CASP2,CD209,CEBPD,CELSR1,CGAS,CSMD3,CUBN,Cyp2d22,DGAT1,DUT,ETNK1,FAM111A,FAT4,FGL1,FRRS1,FUT6,GLB1,HCRTR2,HNRNPM,ITGB3,KIFC1,KMT5A,KRT8,L1CAM,Lgals6,LRP4,LRP5,MATR3,MGAT4C,MKX,MMRN1,NUBP1,PGK1,PIF1,PLG,PLIN2,PNLIP,PPP1CA,PRKCSH,PTPRK,RAB11A,REG1A,RRM2,SCARF1,SLC16A7,SNAP25,SYT12,TENM3,TMPRSS6,TNFSF14,TNR,TRAF3IP2,TRIM2,TRIM56,TRPM2,TSG101,TULP4,VPS25 73 (60) 55 CASP3,IgG AKT1,ceramide,Focal adhesion kinase,GGPS1,IRAK3,LPAR1,NOX4,TNFRSF11A nelfinavir chemical drug 3 0.762 3.13E-05 5.30E-03 2-amino-1-methyl-6-phenylimidazo-4-5-b-pyridine,20s proteasome,26s Proteasome,ABCB4,Akt,AKT1,AR,beta-estradiol,CDK2,CDKN1B,CFTR,clopidogrel,CREB1,CTNNB1,CYP19A1,CYP1A2,CYP2C19,DLX5,EIF2AK3,ETS2,HIF1A,HMOX1,HSP90AB1,IL1B,Inflammasome,IRF3,KLF4,MAPT,MYC,MYOD1,nelfinavir,NFATC2,NGEF,NR1I2,P glycoprotein,PPARGC1A,PSMB1,SMARCA4,SOX2,SPARC,SREBF2,STING1,STK11,TNFSF11,TWIST1 ABCA3,ADRM1,AIMP2,AKNA,ANGPTL3,ANOS1,ASPG,BBX,BIRC2,BIRC3,C1QL1,CACHD1,CEBPD,CGAS,CHAC1,CLPB,CUBN,Cyp2d22,CYP39A1,DGAT1,EMILIN2,EMX2,FAM111A,FASN,FAT4,FCGBP,FRRS1,GSTM3,HCRTR2,HNRNPM,HSD3B2,L1CAM,Lgals6,LRP4,MATR3,MEGF10,MEGF11,MGAT4C,MKX,MMRN1,NANOS1,PLG,PNLIP,POU3F3,RAB11A,REG1A,RRM2,SCARF1,SERINC2,SLC16A4,SLC16A7,SNAP25,SOD3,SSPOP,SVEP1,SYT12,TMPRSS6,TNFSF14,TNR,TRAF3IP2,TRIM2,TRIM36 62 (45) 40 ATF3,HMOX1,PPP1R15A,RNF41,TSC22D3 AKT1 DIO1 enzyme 3 -1.461 3.19E-05 1.20E-03 AKT1,Ap1,CFTR,CYP19A1,DIO1,DIO2,DIO3,ERK,ERK1/2,GRIN3A,levothyroxine,MIF,NOS3,Pkc(s),PNPT1,PRKCE,RB1,RBL2,STAT1,thyroid hormone,TSH,VDR ACAA1,ADAMTS16,ADGRG6,AOC1,ASPG,BIRC3,CALCRL,CALM1 (includes others),CASP2,CEBPD,CELSR1,CHRNB3,DGAT1,FASN,H2BC21,HCRTR2,HNRNPM,IFI44,ITGB3,KIFC1,KRT8,LRP5,MAPK4,MATR3,PPP1CA,SERINC2,SLC16A4,SOD3,SYCE2,SYT12 30 (22) 21 forskolin,PPARA,SCD,SLC5A5 DIO2,NFkB (complex) thyroid hormone KN 93 chemical drug 2 Activated 2.596 3.50E-05 3.30E-03 Akt,AKT1,Ap1,Creb,CREB1,CTNNB1,EIF2AK2,ERK,ERK1/2,Jnk,JUN,KN 93,MAPK1,MAPK14,MAPK3,MAPT,NFKBIA,P38 MAPK,Pkc(s),RB1 ACAA1,ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,ASPG,B4GALT1,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CLEC10A,DPY19L3,EMX2,FLNC,H2BC21,HNRNPM,ITGB3,KIFC1,KRT8,LITAF,LRP6,MAPK4,MATR3,MGAT4C,NCAN,PGK1,PLG,PLIN2,POLI,PTPRK,RRM2,SERINC2,SOD3,SUSD2,TNFSF14 38 (20) 19 Cofilin AKT1,ATF2,CALC,CAMK2,CASP3,HAS2,LHB,MAP3K7,PEA15 lycopene chemical drug 3 Activated 2.321 3.57E-05 5.70E-03 26s Proteasome,ACHE,Akt,APP,AR,CASP3,CAT,CDK2,CDK4,CDKN1B,CDKN2A,COP1,CREB1,CTNNB1,CXCL8,CYP19A1,CYP1A1,DICER1,E2F3,EGFR,EGLN,EIF2AK3,EIF4E,ESR2,FOS,GLI1,Hdac,HIF1A,HRAS,hydrogen peroxide,IGF1,IGF1R,INSR,IRF3,lycopene,MAPT,MITF,MMP9,MTOR,NGEF,NR1I2,NRAS,oxaliplatin,P38 MAPK,PPARA,PPARGC1A,quinacrine,RAS,RB1,RBL2,reactive oxygen species,RICTOR,S100A9,SIRT1,SMARCA4,SOX2,SREBF2,STING1,STK11,TGFB1,TNF,TWIST1 ADRM1,AIMP2,AKNA,ANGPT2,ANGPTL3,ANK1,ANOS1,ASPG,ATL2,B4GALT1,BCHE,BIRC2,C1QL1,C1QTNF3,CACHD1,CALCRL,CALML3,CEBPD,CELSR1,CGAS,CLPB,CR1,Cyp2d22,CYP39A1,EMILIN2,FAM111A,FASN,FAT4,FCGBP,GSTM3,H2BC21,HCRTR2,HSD3B2,ITGB3,KIFC1,LRP4,LRP5,MAPK4,MGAT4C,NLGN2,NUBP1,PIF1,PLG,PNLIP,PRKCSH,REG1A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC5A7,SNAP25,SOD3,SUSD2,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TNXB,TPPP3,TRIM36,TRIM56,VPS25 67 (62) 55 CASP3,MMP7 TRPC4AP transporter -0.000 3 1.155 3.80E-05 7.10E-03 AHR,Akt,Ap1,ATF4,CCND1,CEBPA,CSF2,CXCL8,cytokine,ERK,estrogen receptor,HIF1A,HNF4A,IKBKB,IL1B,IL6,IRF3,JUN,MDM2,MYCN,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,PPARG,PPARα-RXRα,REL,SP1,STAT1,STAT4,STAT5A,TRPC4AP ABCA3,ACAA1,ADGRG6,AGA,AIMP2,ALDH7A1,ANGPT2,ANGPTL3,ANOS1,AOC1,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALM1 (includes others),CD209,CEBPD,CHAC1,CLEC10A,CR1,Cyp2d22,CYP39A1,EMILIN2,FGL1,FLNC,FUT6,GNAO1,GSTM3,HSD3B2,IFI44,ITGB3,L1CAM,LITAF,LRP6,MMRN1,NCAN,PGK1,POLI,PTPRK,REG1A,SLC16A4,SLC16A7,SOD3,SYT12,TMPRSS6,TNFSF14,TRAF3IP2,WRN 48 (33) 32 NFkB (complex) adaphostin chemical drug 3 -0.258 4.12E-05 5.40E-03 ACHE,adaphostin,Akt,APP,BCR-ABL1,BHLHE40,CASP3,CASP8,CDK2,CDKN1B,CDKN2A,COP1,Cyclin E,DICER1,DLX5,E2F3,EIF2AK3,ERK1/2,ESR2,ETS2,FADD,FMR1,Gsk3,HIF1A,HNF1A,HNF4A,HRAS,IGF1,IL10,IL1B,IL6,Jnk,KRT8,MAFB,MAPK14,MYB,NFATC2,NGEF,P38 MAPK,PRKCE,RB1,RPS6KB1,RXRA,S100A9,SIRT1,SMARCA4,SOX2,STK11,TGFB1,TP53 AIMP2,AKNA,ANGPT2,ANGPTL3,ANK1,AOC1,ATL2,BBX,BCHE,BIRC2,C1QL1,CALCRL,CALML3,CASP2,CD209,CEBPD,CELSR1,CHRNB3,CLEC10A,CLPB,CR1,CSMD3,DUT,ETNK1,FAM111A,FGL1,FUT6,GLB1,H2BC21,HCRTR2,KIFC1,L1CAM,LRP5,LRP6,MAPK4,MKX,PGK1,PKD1L2,PNLIP,POU3F3,PPP1CA,PTGIR,REG1A,RRM2,RRP12,SCARF1,SLC16A4,SLC5A7,SNAP25,SYCE2,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TPPP3,TRAF3IP2,TRIM36,TSG101,TULP4 60 (50) 44 CASP3 RPS6KB1 hydrogen sulfide chemical - endogenous mammalian 3 -0.508 4.16E-05 5.30E-03 26s Proteasome,Akt,AKT1,APP,AR,CEBPA,CFTR,COP1,DLX5,doxorubicin,EIF4E,FGFR2,HMOX1,HNF1A,HNF4A,HRAS,hydrogen sulfide,IFNAR1,IL10,IRF3,IRS1,KRT8,MAPK1,MAPK14,MAPK3,MYB,MYOD1,NGEF,NOS3,NRAS,PDPK1,PI3K (complex),Pkg,PPARGC1A,PRKCE,PTEN,REL,RGS4,RXRA,S100A9,SIRT1,SOX2,SPARC,SPP1,SREBF2,STAT3,STAT4,TGFB1,TNFSF11 ACAA1,ADRM1,AGA,AIMP2,ANGPT2,ANGPTL3,ANOS1,B4GALT1,BCHE,BIRC2,BIRC3,C1QL1,CALCRL,CALML3,CD209,CEBPD,CELSR1,CGAS,CHRNB3,CR1,CUBN,Cyp2d22,CYP39A1,EMILIN2,FGL1,FLNC,FRRS1,FUT6,HCRTR2,HNRNPM,IFI44,ITGB3,KMT5A,L1CAM,Lgals6,LRP4,LRP6,MATR3,MEGF6,MMRN1,NLGN2,PGK1,PKD1L2,PLG,POU3F3,PTPRK,RAB11A,REG1A,RRM2,SCARF1,SOD3,SSPOP,SVEP1,SYT12,TENM3,THSD4,TNFSF14,TNR,TPPP3,TRIM2,TULP4,VPS25 62 (49) 47 Ca2+ AKT1,carbon monoxide,HMOX1,Hsp90,IRS1 lead acetylcholine chemical - endogenous mammalian 3 -0.640 4.52E-05 2.40E-03 acetylcholine,ACHE,Akt,AMPK,APP,AR,CD40LG,CDKN1B,CEBPA,CFTR,CHRM1,CHRM2,CHRM3,CHRM5,CHRNA7,CNR1,CNTF,COP1,Creb,doxorubicin,EIF2AK3,EIF4E,ELAVL1,EPAS1,ERK1/2,ESR2,ETS2,FADD,GLI1,HIF1A,IFNG,IGF1,IL17F,IL1B,IL2,IL4,INSR,KDR,Mapk,MAPK3,MAVS,mir-21,MITF,MLXIPL,MYB,NGEF,nitric oxide,Nos,NOS3,NRAS,P38 MAPK,Pka,PLC,PLK1,PPARD,PRKCE,Pro-inflammatory Cytokine,RGS4,Rsk,S100A9,SMTNL1,SNCA,STAT3,STING1,TGFB1,TNFSF11,TWIST1,XDH AIMP2,ANGPT2,ANK1,AOC1,ATL2,B4GALT1,BCHE,BIRC3,C1QTNF3,CACHD1,CALML3,CD209,CEBPD,CGAS,CHRNA10,CHRNB3,CLPB,CUBN,Cyp2d22,DPY19L3,ETNK1,FASN,FAT4,FCGBP,FLNC,FRRS1,H2AC21,HSD3B2,ITGB3,KMT5A,L1CAM,LRP4,MEGF10,MEGF11,MEGF6,MFSD1,MKX,MMRN1,NLGN2,PGK1,PIF1,PLG,PNLIP,PTGIR,PTPRG,RRP12,SCARF1,SLC16A4,SLC5A7,SOD3,SSPOP,SYT12,THSD4,TKFC,TMPRSS6,TNFSF14,TPPP3,TRAF3IP2,TRIM3,VPS25,XPO7 61 (68) 55 galanthamine,GDF2,pregnenolone sulfate,rivastigmine,scopolamine ACHE,NR5A2,SENP2 Ca2+,CHRM1,CHRM2,CHRNA4,cyclic ADP-ribose,NMDA Receptor GNAI3,XDH KT5823 chemical - kinase inhibitor 3 1.522 5.09E-05 1.03E-02 ABCB4,Akt,AKT1,Ap1,APP,ATF4,CASP3,CDKN1B,CDKN2A,CEBPA,CFTR,CHUK,CITED2,COP1,Creb,CREB1,CTNNB1,CYP19A1,DICER1,EIF4E,ERK,ERK1/2,ESR1,ETS2,FOS,GLI1,Hdac,HIF1A,HNF1A,HNF4A,HRAS,IFNAR1,IGF1,IKBKB,IL10,IRF3,ITPR1,KT5823,MAPK1,MAPK14,MAPK3,MAPT,MITF,MYOD1,NFATC2,NFkB (complex),NFKB2,NGEF,NRAS,P glycoprotein,P38 MAPK,Pkg,PPARGC1A,RAF1,RAS,RGS4,S100A9,Sfk,SIRT1,SLC6A4,SOX2,SPARC,STK11,TGFB1,TNFSF11,TWIST1,Vegf ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,ASPG,ATL2,BBX,BCHE,BIRC2,BIRC3,C1QL1,C1QTNF3,CALM1 (includes others),CALML3,CEBPD,CGAS,CHAC1,CLPB,CR1,CUBN,DPY19L3,EMILIN2,FAM111A,FCGBP,FGL1,FLNC,FRRS1,FUT6,GNAO1,HCRTR2,HNRNPM,IFI44,ITGB3,KRT8,L1CAM,Lgals6,LITAF,LRP4,LRP5,LRP6,MATR3,MEGF6,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PIF1,PKD1L2,PLG,PTPRK,RRM2,SCARF1,SERINC2,SLC16A4,SLC16A7,SOD3,SSPOP,SUSD2,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TPPP3,TRIM2,TRPM2,VPS25 73 (67) 59 CASP3,ITPR1,Na+,K+ -ATPase AKT1,Ca2+,CNN1,CNTF,SLC2A1 Ca2+ chemical - endogenous mammalian 2 -0.687 5.44E-05 1.55E-02 ADAM12,Akt,AKT1,APP,Ca2+,CASR,CEBPB,CFTR,Creb,CREB1,CTNNB1,CXCL8,CYP19A1,DICER1,EGFR,EIF2AK3,ERK,ERK1/2,F2,F5,FOS,G protein alphai,GPRC6A,HRAS,Jnk,JUN,MAPK1,MAPK3,MAPK9,MMP2,Nfat (family),NFATC2,NFkB (complex),PKD1,PRKCE,RAF1,STK25,TERT,TWIST1 ADGRG6,AIMP2,ALDH7A1,AOC1,B4GALT1,BBX,C1QTNF3,CALCRL,CEBPD,CELSR1,CHRNB3,CLEC10A,CR1,CUBN,DPY19L3,DUT,EMX2,FASN,FAT4,FCGBP,FLNC,GLB1,GSTM3,HNRNPM,HSD3B2,IFI44,KIFC1,KRT8,L1CAM,LGMN,LITAF,LRP5,MATR3,MGAT4C,MMRN1,NUBP1,PLG,PLIN2,PNLIP,POLI,POU3F3,PPP1CA,SERINC2,SLC16A4,SLC16A7,SUSD2,SVEP1,TENM3,THSD4,TNFSF14,TNXB,TPPP3,TSG101 53 (39) 39 1,2-dioctanoyl-sn-glycerol,1-methyl-4-phenylpyridinium,12(S)-hydroxyeicosatetraenoic acid,4-hydroxycinnamyl aldehyde,8-bromo-cAMP,[D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin,acetylcholine,alpha-estradiol,ASIP,BDKRB2,benzo(a)pyrene,buserelin,calcium chloride,camptothecin,carbon tetrachloride,CCL3L3,CCL7,CCR9,CD19,CDN1163,CHI3L1,chlorocresol,CX3CL1,CXCL10,CXCL9,cyclic ADP-ribose,CYP27B1,denatonium benzoate,DVL1,ESR2,etoposide,F2RL3,FFAR1,FFAR4,FGF4,FGF7,forskolin,G protein,G protein beta gamma,galanthamine,gamma-linolenic acid,HNF4A,IBSP,iloprost,lauric acid,LCP2,lead,leucine,leukotriene B4,lithocholic acid,LY83583,MAS1,Mt,N-arachidonylglycine,nor-binaltorphimine,NRG (family),NUCB2,oleic acid,ouabain,p85 (pik3r),PDGFB,phosphatidylinositol,phytohemagglutinin,PLC gamma,PLCB3,PLCL1,PMP22,pregnenolone sulfate,PRNP,propofol,quercetin,racemic flurbiprofen,RAPGEF3,resiniferatoxin,SAA1,SPHK1,TACSTD2,tauroursodeoxycholic acid,TNFRSF11A,vildagliptin,WNT5A,wogonin,ZP3 8-(4-chlorophenylthio)-guanosine-3', 5'-cyclic monophosphate,anisomycin,ATP2B2,benzamil,Ca2 ATPase,capsazepine,carboxyamido-triazole,D-2-amino-5-phosphonovaleric acid,delta-tocopherol,GRK2,IgG,indomethacin,INS,KT5823,L-cysteine,linsidomine,LRP5,N,N-dimethylsphingosine,nifedipine,PD 123319,pentobarbital,phorbol 12,13-dibutyrate,phosphate,POU2AF1,PPP1R9B,SR 144528,suramin,TFPI,Trolox C,tunicamycin ADAM10,AKT1,ATF3,BCAR1,bile acid,CAMK2,CASP3,caspase,CCND2,DBP,EP300,FASLG,IL31,KRT10,LHB,NFkB (complex),PIK3CA,PLA2G6,PLD1,PNPLA8,PPARA,PPP3CA,PTTG1,radical,RASGRP1,RPS6KB1,sGC,ST14,STK25,TRPM2,VEGFD,YES1 Ank2,ceramide,E2F2,F10,F5,hydrogen sulfide,LPIN1,MMP7,Na+,K+ -ATPase,TERT tozasertib chemical drug 3 1.576 5.53E-05 8.60E-03 ABL1,Akt,AKT1,Ap1,APP,AURK,AURKA,AURKB,BIRC5,CASP3,CDK2,CDKN1B,CEBPA,CREB1,CTNNB1,DICER1,E2F3,EGFR,ERBB2,ESR1,ESR2,estrogen receptor,ETS2,FADD,HIF1A,HIPK2,Histone h3,HMOX1,ITGB1,KLF4,KMT2A,MAPT,MYC,NEDD9,NFATC2,NFKB1,NR1I2,PAWR,PDPK1,RB1,SMARCA4,SNCA,SOX2,SPARC,TNFSF11,tozasertib,TWIST1 ABCA3,AIMP2,AKNA,ANGPT2,ANGPTL3,ANK1,ASPG,BBX,BIRC3,C1QL1,CALCRL,CALM1 (includes others),CEBPD,CELSR1,CHAC1,CLPB,CSMD3,CYP39A1,DPY19L3,EMX2,ETNK1,FASN,FAT4,FCGBP,FLNC,FRRS1,GNAO1,H2BC21,HNRNPM,LRP4,LRP5,MAPK4,MATR3,MEGF11,MGAT4C,MKX,MMRN1,PLG,POU3F3,PTPRK,RAB11A,RRM2,RRP12,SERINC2,SLC16A4,SLC5A7,SNAP25,SUSD2,THSD4,TMPRSS6,TNR,TNXB,TPPP3,TRIM2,TRIM3,TRIM36,TRPM2,XPO7 58 (47) 42 CASP3 AKT1 Secretase gamma complex 2 -1.789 5.66E-05 7.00E-04 Akt,AKT1,MDM2,Notch,NOTCH1,PSEN1,PSEN2,Secretase gamma,TREM2 AIMP2,BIRC2,BIRC3,CASP2,CLEC10A,FASN,H2BC21,HNRNPM,KRT8,L1CAM,MATR3,PGK1,PLG,PTK7,PTPRK,RRM2,TNFSF14,TNXB,TSG101,WRN 20 (9) 8 prostaglandin E2,sphingomyelin 22(R)-hydroxycholesterol,BMS-906024,nirogacestat,phosphatidylinositol MDM2,MME,Notch,SLC2A1 RELN,TREM2 isorhamnetin chemical - endogenous non-mammalian 3 1.213 5.69E-05 7.90E-03 2-amino-1-methyl-6-phenylimidazo-4-5-b-pyridine,ACHE,Akt,Ap1,APP,AR,CDKN1B,CEBPA,COP1,CREB1,CTNNB1,CYP19A1,CYP1A1,EGFR,EIF4E,ERK1/2,ESR1,ESR2,ETS2,FADD,FOS,HIF1A,HNF1A,HNF4A,IFNAR1,IGF1,IL10,IRF3,isorhamnetin,ITGB1,Jnk,KRT8,MAPK14,MAPT,MITF,MYB,MYC,MYOD1,NFATC2,NFkB (complex),NGEF,P38 MAPK,PPARA,PPARGC1A,RAF1,RB1,RICTOR,RXRA,S100A9,SIRT1,STAT4,STK11,TGFB1,TNF,TWIST1,Vegf AIMP2,ALDH7A1,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ASPG,ATL2,BBX,BCHE,BIRC2,BIRC3,CACHD1,CALM1 (includes others),CALML3,CD209,CEBPD,CGAS,CLEC10A,CLPB,CR1,Cyp2d22,EMILIN2,ETNK1,FASN,FAT4,FCGBP,FGL1,FUT6,GSTM3,HCRTR2,ITGB3,L1CAM,Lgals6,LRP6,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PIF1,PKD1L2,PLG,RAB11A,REG1A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SUSD2,SVEP1,SYT12,THSD4,TMPRSS6,TNFSF14,TNR,TNXB,TPPP3,TRIM56,TRPM2,TULP4 68 (56) 55 GSTA1 G protein beta gamma complex 2 -1.414 5.78E-05 2.70E-03 Akt,AKT1,EGFR,ERK,ERK1/2,G protein beta gamma,GNB3,Jnk,MAP2K4,MAPK8,Mek,MMP2,NFkB (complex),PI3K (complex),PI3K (family),PIK3CG,PRKAA1,RGS4,SNCA,SRC ADGRG6,AIMP2,ALDH7A1,ANGPT2,AOC1,BIRC2,BIRC3,CASP2,CD209,CEBPD,CHAC1,CLEC10A,DGAT1,FASN,GNAO1,H2BC21,HNRNPM,HSD3B2,IFI44,KRT8,LITAF,MATR3,MEGF11,MEGF6,PGK1,PLG,RRM2,SOD3,SSPOP,TNFSF14,TNXB,TRIM3 32 (20) 19 AKT1,Ca2+,NFkB (complex),PIK3CG,PLCB3,PRKAA1 RGS4 phospholipid chemical - endogenous mammalian 2 1.095 5.94E-05 2.70E-03 Akt,AKT1,ANXA7,INSR,MGAT1,NFkB (complex),PAK2,PDPK1,phospholipid,Pkc(s),PPARA,PRKCE,PRKCZ,PROC,SNCA,TOP1 ACAA1,AIMP2,ALDH7A1,ANGPT2,B4GALT1,CASP2,CHAC1,CHRNB3,DGAT1,FASN,FCGBP,GLB1,GSTM3,HNRNPM,HSD3B2,ITGB3,KRT8,L1CAM,MATR3,MEGF11,PLG,PLIN2,RAB11A,RRM2,SERINC2,SOD3,TNFSF14,TRIM3,TSG101,WRN 30 (16) 15 PTN,S-adenosylmethionine oleic acid,SAA,SAA1,SCP2,TFPI AKT1,CCL3L3,CXCL10,F10,leukotriene B4,PAK2,PKN2,PTAFR,RPS6KB1 roscovitine chemical drug 3 0.788 5.95E-05 4.10E-03 Akt,AR,ATM,CASP8,Cdk,CDK1,CDK2,CDK5,CDKN2A,CFTR,CHEK1,CHRNA7,COP1,E2F3,FADD,FMR1,FOXO1,GLI1,GRIN1,Gsk3,GSK3B,HIF1A,HIPK2,HNF4A,IGF1,IL1B,IL2,IRF3,Jnk,KAT5,KRT8,MAFB,MAPT,MITF,MLXIPL,NCL,NGEF,NMDA Receptor,NRAS,P38 MAPK,PDPK1,Pka,PPARG,PPARGC1A,PRKN,PRNP,progesterone,RB1,RGS4,roscovitine,RPS6KB1,Rsk,S100A9,SMARCA4,SNCA,SOX2,SREBF2,STAT5A,STING1,STK11,SYN1,TSC1 ACAA1,AGA,AIMP2,AKNA,ANGPT2,ANK1,ANOS1,ASPG,ATL2,BCHE,BIRC2,C1QL1,C1QTNF3,CALCRL,CASP2,CD209,CELSR1,CGAS,CHRNA10,CLEC10A,CUBN,Cyp2d22,DGAT1,EMILIN2,ETNK1,FAM111A,FUT6,GLB1,H2BC21,HSD3B2,ITGB3,L1CAM,LRP4,MAPK4,MEGF11,MEGF6,PIF1,PLIN2,POLI,PTGIR,RAB11A,REG1A,RRM2,SCARF1,SLC16A4,SOD3,SSPOP,SVEP1,SYCE2,SYT12,TKFC,TMPRSS6,TNFSF14,TRAF3IP2,TRIM3,TRIM36,VPS25,XPO7 58 (62) 48 CYP2B6,NMDA Receptor CASP3,MDM2,PRNP,RPS6KB1 NOX1 enzyme 3 0.372 6.04E-05 8.10E-03 AGT,AHR,Akt,AKT1,APP,CDKN1B,CHUK,CREB1,CTNNB1,CXCL8,CYP19A1,EGFR,ERK,ERK1/2,ESR1,ETS2,FADD,FOS,HIF1A,HIPK2,HNF4A,HRAS,IL10,IL1B,IL6,IL6ST,Jnk,MAPT,MITF,MMP9,MYC,MYCN,NEDD9,NFATC2,NFkB (complex),NFKB2,NFKBIA,NGEF,NOX1,NRAS,PDPK1,PPARA,PRKCE,PTPase,PTPN11,PTPRJ,RAF1,RICTOR,ROCK,SIRT1,SMAD2,SNCA,SOX2,SPARC,SRC (family),STK11,TNF,TNFSF11,TWIST1,WBP2 ABCA3,ADGRG6,ADRM1,AIMP2,ALDH7A1,ANGPT2,AOC1,ASPG,B4GALT1,BBX,C1QL1,C1QTNF3,CD209,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,ETNK1,FAT4,FCGBP,FGL1,FRRS1,FUT6,HCRTR2,HNRNPM,ITGB3,KRT8,LITAF,LRP4,MATR3,MEGF11,MGAT4C,MKX,NCAN,NUBP1,PIF1,PLG,PNLIP,RAB11A,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SOD3,SSPOP,SUSD2,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TNXB,TPPP3,TRAF3IP2,TRIM2,TRIM3,TRIM56,TRPM2,TULP4,VPS25,XPO7 65 (60) 55 6-hydroxydopamine,PD 123319,PLA2G6 AKT1,Cofilin,EPAS1,NFkB (complex) HMOX1 linsidomine chemical drug 3 Inhibited -2.077 6.09E-05 1.05E-02 20s proteasome,AKT1,ALOX15,Ap1,APP,AR,CDKN1B,CEBPA,CEBPB,COP1,CREB1,CXCL8,EIF2AK3,ERK,ERK1/2,ESR1,ESR2,ETS2,ETV4,FOS,GATA1,GSK3B,HIF1A,HMOX1,HNF1A,HNF4A,HRAS,IDH1,IFNAR1,IGF1,IL10,IL2,INSR,IRF3,KLF6,KRT8,LGALS3,linsidomine,MAPK11,MAPK13,MAPK14,MAPK8,MAPT,MDM2,MITF,MYC,MYCN,MYOD1,NFATC2,NFKBIA,NOS1,P38 MAPK,PPARGC1A,PRKCE,PSMB1,PTGS1,RAF1,RICTOR,S100A9,SIRT1,STAT4,STK11,TGFB1,TP53,VitaminD3-VDR-RXR ADGRG6,ADRM1,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ASPG,ATL2,B4GALT1,BBX,BCHE,BIRC2,BIRC3,CALM1 (includes others),CALML3,CGAS,CHRNB3,CLPB,CR1,CSMD3,Cyp2d22,DGAT1,DUT,EMILIN2,FASN,FCGBP,FGL1,FUT6,HCRTR2,HNRNPM,ITGB3,Lgals6,LGMN,LRP5,LRP6,MATR3,MEGF10,MGAT4C,MKX,MMRN1,NCAN,NUBP1,PIF1,PKD1L2,PLG,PNLIP,POU3F3,PPP1CA,PRKCSH,PTGIR,REG1A,RRM2,RRP12,RSL24D1,SLC16A4,SLC16A7,SLC5A7,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TPPP3,TRPM2,TSG101 67 (65) 59 carbon monoxide,CDKN2A,HMOX1,PPARD Ca2+,FASLG,OPRK1 LIF cytokine 3 Inhibited -2.528 6.23E-05 1.03E-02 26s Proteasome,AHR,Akt,AKT1,APP,CAMK4,CaMKII,CASP3,CDKN1B,CDKN2A,CREB1,DICER1,EIF4E,EPAS1,ERK,ERK1/2,ETS2,FADD,FOS,Gsk3,Hdac,HIF1A,HNF1A,HRAS,IFNG,IGF1,IL10RA,IL2,IL6ST,JAK,JAK1,JAK2,Jnk,L-tyrosine,LIF,MAFB,MAP2K1,MAP2K1/2,MAP2K5,Mapk,MAPK1,MAPK3,mir-21,MITF,MYOD1,NGEF,NRAS,P38 MAPK,p70 S6k,PDPK1,PGR,PI3K (complex),PIM1,PPARA,PPARGC1A,PPP3R1,RAF1,REL,RICTOR,Rsk,RUNX3,SOCS3,SOX2,SPARC,STAT1,STAT3,STAT4,STAT5A,STK11,TNF,TNFSF11,YAP1 ABCA5,ADGRG6,ADRM1,AGA,AIMP2,ANGPT2,ANK1,AOC1,ATL2,B4GALT1,BIRC2,BIRC3,C1QL1,CACHD1,CD209,CEBPD,CGAS,CHAC1,CLEC10A,CLPB,Cyp2d22,EMILIN2,ETNK1,FAM111A,FGL1,FLNC,FRRS1,FUT6,GLB1,GSTM3,H2AC21,HNRNPM,HSD3B2,IFI44,ITGB3,L1CAM,Lgals6,LITAF,LRP4,LRP5,MATR3,MGAT4C,MKX,NLGN2,NUBP1,PGK1,PIF1,PKD1L2,PLG,PTGIR,PTPRK,RAB11A,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SVEP1,TENM3,THSD4,TMPRSS6,TNFSF14,TPPP3,TRIM2,TRIM56,TRPM2,VPS25 69 (72) 60 8-bromo-cAMP,BHLHE40,CNTF,PROCR AKT1,BMP7,CCL3L3,CCNE1,CDH5,CISH,CXCL10,cytokine receptor,FGF4,NMI,PLD1,RGS4,SOCS3,TMEM176B,WNT5A AHNAK,anandamide,CASP3,DSPP,IBSP,PGR anandamide chemical - endogenous mammalian 3 -1.116 6.27E-05 6.50E-03 AKT1,anandamide,Ap1,APP,AR,ATF4,CASP3,CDKN1B,CDKN2A,CNR1,COP1,CTNNB1,CXCL8,CYP19A1,DICER1,EIF4E,ERK,ERK1/2,ESR1,ESR2,ETS2,FAAH,FADD,GRIN3A,HIF1A,Histone h3,HNF1A,HNF4A,HRAS,IFNAR1,IGF1,IL10,IL2,IRF3,Jnk,KMT2A,KRT8,MAPK14,MAPT,MITF,MYB,MYOD1,NEDD9,NFATC2,NFkB (complex),NFKB1,NMDA Receptor,NOS1,NRAS,P38 MAPK,p70 S6k,PAWR,PGR,PPARA,PPARGC1A,PRKCE,PTK2,RICTOR,S100A9,SIRT1,SOX2,SPARC,STAT4,TGFB1,TNF,TNFSF11,TRPV1,TWIST1 ADGRG6,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,ASPG,ATL2,BBX,BCHE,BIRC2,C1QL1,CALM1 (includes others),CALML3,CEBPD,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,Cyp2d22,EMILIN2,ETNK1,FAM111A,FAT4,FCGBP,FGL1,FRRS1,FUT6,GNAO1,GSTM3,HCRTR2,HNRNPM,ITGB3,Lgals6,LRP4,LRP5,LRP6,MATR3,MKX,NLGN2,PIF1,PKD1L2,PLG,PLIN2,POU3F3,PTGIR,REG1A,RRM2,RRP12,RSL24D1,SLC5A7,SUSD2,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TPPP3,TRIM2,TRIM56,TRPM2,TULP4,VPS25 65 (68) 62 6-hydroxydopamine,cyclophosphamide,oleic acid LIF AKT1,ANGPTL4,BCAR1,cannabinoid receptor,CASP3,HSBP1,PPARD NMDA Receptor,NTRK1 8-(4-chlorophenylthio)-guanosine-3', 5'-cyclic monophosphate chemical reagent 3 -1.364 6.35E-05 6.60E-03 26s Proteasome,8-(4-chlorophenylthio)-guanosine-3', 5'-cyclic monophosphate,ACHE,Akt,APP,AR,ATF4,CDKN1B,CEBPA,CFTR,CITED2,COP1,Creb,CREB1,CTNNB1,EIF2AK3,EIF4E,ERK,ERK1/2,ESR1,ESR2,ETS2,FOS,HIF1A,HNF1A,HNF4A,HRAS,Hsp27,IFNAR1,IL10,IRF3,MAPK1,MAPK14,MAPK8,MITF,MPRIP,MYB,MYOD1,NFAT (complex),NFATC2,NFKBIA,NGEF,PGR,Pkg,PPARA,PPARGC1A,PPP1R1B,PRKG1,RAF1,RB1,RICTOR,RXRA,S100A9,SIRT1,STAT4,STK11,TGFB1 ADGRG6,ADRM1,AIMP2,ANGPT2,ANGPTL3,ANOS1,AOC1,B4GALT1,BBX,BCHE,BIRC2,BIRC3,CALML3,CEBPD,CGAS,CHAC1,CLPB,CR1,CUBN,Cyp2d22,DGAT1,DPY19L3,EMILIN2,FASN,FGL1,FLNC,FUT6,GSTM3,HCRTR2,IFI44,ITGB3,L1CAM,Lgals6,LRP6,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NCAN,NLGN2,NUBP1,PIF1,PKD1L2,PLG,PNLIP,PTPRK,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SUSD2,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TPPP3,TRPM2,TULP4 65 (57) 50 cyclic ADP-ribose,LASP1 Ca2+,CCL3L3 STO-609 chemical - kinase inhibitor 3 1.134 6.44E-05 9.00E-03 26s Proteasome,ACACA,ACHE,Akt,AMPK,Ap1,APP,AR,ATF4,BAD,CAMK4,CDKN1B,CEBPA,Creb,CREB1,CTNNB1,CYP19A1,doxorubicin,EGFR,EIF2AK3,EIF4E,ELAVL1,ELK1,ERK1/2,ESR1,ESR2,ETS2,FADD,FOS,Hdac,HNF4A,HRAS,IL10,INSR,IRF3,ITGB1,Jnk,KRT8,MAPT,MITF,MLXIPL,MYC,MYOD1,NFkB (complex),NGEF,NOS3,NR1I3,PPARA,PPARGC1A,PRKAA,RAF1,RB1,RICTOR,RXRA,SIRT1,STO-609,TNF,TSC1,TWIST1,Vegf ADRM1,AGA,AIMP2,ALDH7A1,ANGPT2,ANGPTL3,ANOS1,AOC1,ASPG,BIRC2,BIRC3,CACHD1,CALM1 (includes others),CD209,CHAC1,CLEC10A,CLPB,CR1,Cyp2d22,CYP39A1,DPY19L3,EMILIN2,ETNK1,FASN,FAT4,FCGBP,FUT6,HCRTR2,ITGB3,KMT5A,L1CAM,Lgals6,LRP4,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PIF1,PLG,PNLIP,REG1A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A7,SLC5A7,SOD3,SUSD2,SVEP1,TENM3,THSD4,TKFC,TNFSF14,TNR,TNXB,TPPP3,TRIM56,TRPM2 63 (60) 56 Cofilin phytohemagglutinin chemical drug 3 0.000 6.60E-05 8.70E-03 ACHE,ADCY,AHR,Akt,Ap1,APP,CASP3,CDK4,CDKN1B,CDKN2A,CLOCK,CREB1,CTNNB1,CXCL8,CYP19A1,DICER1,DOCK8,EGLN,EIF4E,ELAVL1,ERK,ESR1,ESR2,FADD,FOS,GNE,Hdac,HIF1A,HNF4A,HRAS,IGF1,IL1B,IL2,IL6,Jnk,LCK,MAFB,MAPT,Nfat (family),NFATC2,NFkB (complex),NGEF,NRAS,phytohemagglutinin,Pkc(s),PLC gamma,PPARA,PPARGC1A,PRKCA,PRKCE,PRKCQ,RB1,REL,RELA,RICTOR,SIRT1,SLC18A3,STK11,TERT,TNF,TWIST1,USP15,USP7,USP9X ADGRG6,AGA,AIMP2,ALDH7A1,ANGPT2,ANOS1,ASPG,ATL2,B4GALT1,BBX,BCHE,BIRC2,BIRC3,CACHD1,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,DDX20,ETNK1,FAM111A,FAT4,FGL1,FUT6,GLB1,H2BC21,HCRTR2,IFI44,ITGB3,KRT8,L1CAM,LRP4,LRP5,MAPK4,MEGF10,MGAT4C,NLGN2,NUBP1,PLG,PLIN2,PTGIR,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC5A7,SOD3,SUSD2,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM56,TRPM2,TULP4,VPS25 70 (64) 56 ARR3,Ca2+,CASP3,CCND2,CCR7,CXCL10,ENG,FASLG,FGFR3,FGR,GSTT1,KIT,KLRC4-KLRK1/KLRK1,NFkB (complex),PEMT,PGF,PLC gamma,PLD1,RASA1,RXRA,SPHK1,TERT,TFAM,TFPI,TRAF1,VAMP7 HCFC1 chalcone-24 chemical reagent 1 1.414 6.64E-05 1.00E-04 chalcone-24 BIRC2,BIRC3 2 (1) 1 nefiracetam chemical drug 3 -1.567 6.80E-05 3.50E-03 Calcineurin protein(s),CaMKII,CHRNA7,CHRNB2,Creb,CREB1,DUSP1,ERK,ERK1/2,GRIN3A,L-glutamic acid,MAPK1,MAPK14,MAPK8,MAPT,nefiracetam,Nfat (family),NFkB (complex),nicotinic acetylcholine receptor,NMDA Receptor,NRAS,NTRK2,P38 MAPK,Pkc(s),SRC,SRC (family) ADGRG6,ALDH7A1,ANGPT2,ANK1,AOC1,ASPG,BIRC2,BIRC3,CALCRL,CEBPD,CHRNA10,CLEC10A,DGAT1,DPY19L3,FLNC,HCRTR2,IFI44,ITGB3,KRT8,LITAF,LRP6,MGAT4C,PGK1,PLIN2,PTPRK,RRM2,SERINC2,SNAP25,SOD3,TNFSF14,TSG101,TULP4,VPS25 33 (26) 22 NMDA Receptor CSNK1D kinase -0.000 3 -0.630 6.81E-05 1.89E-02 26s Proteasome,AKT1,Ap1,APC,ARNTL,AXIN1,BACE1,BHLHE40,CDH1,CDKN2A,CEBPA,CREB1,CSNK1D,CTNNB1,cytarabine,DVL1,DVL2,EIF2AK3,EIF4E,ESR1,estrogen receptor,genistein,GJA1,HIPK2,HNF4A,IL1B,IL6,Jnk,LRRK2,MAPT,MDM2,NCOA3,NFATC2,NR5A2,PER2,PGR,PPARGC1A,PPIF,PRKCE,PRKN,PSEN2,REST,RIPK3,RUNX3,SNCA,SOX2,STING1,T3-TR-RXR,tetradecanoylphorbol acetate,TP53,TSG101,VDR,VitaminD3-VDR-RXR ACAA1,ADRM1,AGA,ANK1,ASPG,BBX,BIRC2,C1QL1,CALCRL,CALM1 (includes others),CASP2,CELSR1,CGAS,CHRNB3,CLEC10A,CSMD3,CUBN,DUT,EMILIN2,EMX2,FAM111A,Fcna,FGL1,FLNC,FUT6,GLB1,GSTM3,H2BC21,HCRTR2,HNRNPM,ITGB3,KIFC1,L1CAM,LRP4,LRP5,MATR3,MEGF11,MGAT4C,MMRN1,NLGN2,PIF1,PNLIP,PPP1CA,PTGIR,PTPRG,PTPRK,RAB11A,REG1A,RRM2,SCARF1,SERINC2,SNAP25,SUSD2,SVEP1,SYT12,TNR,TNXB,TRAF3IP2,TRIM3,TRPM2,TSG101,WRN,XPO7 63 (53) 42 camptothecin,etoposide,prednisolone,SETD2 DVL1,LRRK2,MDM2,NCOA3 FANCC other 3 -0.630 6.99E-05 1.18E-02 26s Proteasome,AHR,APP,ATF3,ATM,CD24,CD40,Cdc2,COP1,Creb,CREB1,CTNNB1,CXCL8,CYP19A1,EIF2AK2,ESR2,FADD,FANCC,HIF1A,HIPK2,HNF4A,Hsp70,IFNGR1,IGF1,IL10RA,IL1B,IL6ST,IRF3,JAK1,Jnk,LEP,MAPT,MDM2,mir-21,MITF,mitomycin C,MYB,NFATC2,NFkB (complex),NFKB2,NPM1,NR1I2,P38 MAPK,POR,POU2F2,PPARA,PPARGC1A,PRKRA,RB1,REL,RICTOR,RXRA,S100A9,SIRT1,SMARCA4,STAT1,STAT3,STAT5A,STAT5B,STK11,TNF,TP53,TWIST1,TYK2 ADRM1,AGA,ALDH7A1,ANGPT2,ANGPTL3,ANK1,ANOS1,ARL6IP4,ASPG,ATL2,B4GALT1,BBX,BCHE,BIRC2,C1QTNF3,CACHD1,CLEC10A,CLPB,CR1,CSMD3,CYP39A1,DPY19L3,ETNK1,FASN,FAT4,FCGBP,FGL1,FUT6,H2BC21,HCRTR2,HSD3B2,ITGB3,KIFC1,MAPK4,MEGF10,MGAT4C,PGK1,PIF1,PLG,POU3F3,PPP1CA,RAB11A,REG1A,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC5A7,SOD3,SUSD2,SVEP1,SYT12,THSD4,TMPRSS6,TNR,TPPP3,TRAF3IP2,TRIM2,TRIM36,TRIM56,TULP4,XPO7 63 (64) 57 lactacystin GnRH-A,prednisolone SFRP1 FZD4,NFkB (complex) p85 (pik3r) group 3 0.000 7.05E-05 1.37E-02 26s Proteasome,AHR,Akt,AKT1,ANGPT1,Ap1,APP,CASP3,CDKN1B,CITED2,CREB1,CXCL8,DICER1,EIF2AK3,ELAVL1,ERK1/2,ESR1,ETS2,FMR1,FOS,HIF1A,HNF4A,IGF1,IL10,IL1B,IL2,IL6,IL6ST,ITGB1,MAPK1,MAPK3,Mek,mir-21,MITF,MYOD1,NEDD9,NFATC2,NFkB (complex),NFKB2,NGEF,NRAS,p85 (pik3r),PDPK1,PI3K (complex),PIK3R1,PPARA,PPARGC1A,PTK2B,PTPN11,RAF1,REL,RICTOR,RPS6KB1,SNCA,SOX2,SPARC,SREBF2,STAT3,STK11,TCF7L2,TNFSF11,TWIST1 ABCA3,ADRM1,AGA,AIMP2,ALDH7A1,ANGPT2,AOC1,ATL2,B4GALT1,BBX,BIRC2,BIRC3,C1QL1,C1QTNF3,CACHD1,CALM1 (includes others),CASP2,CD209,CGAS,CHAC1,CLPB,CR1,FASN,FCGBP,FGL1,FLNC,FRRS1,FUT6,HNRNPM,IFI44,KMT5A,L1CAM,Lgals6,LRP4,LRP5,LRP6,MATR3,MEGF11,MGAT4C,MKX,NUBP1,PGK1,PIF1,PLG,PNLIP,PTGIR,PTPRK,RAB11A,REG1A,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SOD3,SVEP1,SYCE2,SYT12,THSD4,TMPRSS6,TNFSF14,TNR,TNXB,TPPP3,TRAF3IP2,TRIM2,TRIM3,TRPM2,VPS25 70 (62) 57 CAPNS1,CD19,KIT,L-triiodothyronine,NTRK1,oleic acid,PDGFB leucine,MEN1 AKT1,Ca2+,NFkB (complex),RPS6KB1 CASP3,RASA1 suramin chemical drug 2 -0.164 7.10E-05 6.20E-03 Akt,AKT1,doxorubicin,EGFR,ERK1/2,FHIT,FSHR,INSR,MAPK1,MAPK3,mitomycin C,NFkB (complex),P38 MAPK,PRKCZ,PRMT1,RELA,SIRT1,SMAD3,STAT3,suramin ABCA3,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,CASP2,CD209,CEBPD,CLEC10A,DGAT1,FCGBP,FLNC,GLB1,GSTM3,HCRTR2,HNRNPM,HSD3B2,IFI44,ITGB3,KMT5A,KRT8,L1CAM,LGMN,LRP5,MATR3,PGK1,PLG,RAB11A,RRM2,SOD3,TNFSF14,TNXB,TSG101,TULP4 37 (20) 19 HMOX1,mitomycin C AKT1,Ca2+,CASP3,caspase,CDH2,MSTN,NFkB (complex),prostaglandin E2 tyrosine kinase group 3 0.372 7.14E-05 9.50E-03 AHR,Akt,APP,CAV1,CDK1,CREB1,CTNNB1,CXCL8,CYP19A1,CYP1A1,DLX5,E2F3,EIF4E,ERBB2,ERBB3,ERK1/2,ESR1,estrogen receptor,ETS2,FER,GRIN3A,HIF1A,HNF4A,HRAS,IL10,IL1B,IL6ST,IRF3,JAK,KIT,KMT2A,LCK,MAPT,MITF,MYOD1,NFkB (complex),NGEF,NRAS,PIK3CA,PIK3CB,PIK3CD,PKD1,PLC,Pld,PPARA,PPARGC1A,PRKCE,PTPRJ,RAS,REL,RHOA,RICTOR,RUNX3,SNCA,SOX2,SRC,STAT,STK11,TRIM28,TSC1,TWIST1,tyrosine kinase,WBP2,WWOX ADRM1,AGA,AIMP2,AKNA,ALDH7A1,ANGPT2,ANOS1,AOC1,ASPG,BBX,BIRC2,BIRC3,C1QL1,CACHD1,CD209,CEBPD,CGAS,CHAC1,CHRNB3,CR1,DPY19L3,FASN,FAT4,FCGBP,FLNC,FUT6,GSTM3,HCRTR2,ITGB3,KRT8,L1CAM,Lgals6,LRP6,MEGF11,MGAT4C,MKX,NLGN2,PGK1,PIF1,PLG,POLI,POU3F3,PTPRK,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC5A7,SOD3,SUSD2,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TNXB,TRAF3IP2,TRIM2,TRIM3,TRPM2,TULP4,VPS25 65 (64) 52 paraquat,PPARA KIT,NFkB (complex),PIK3CA,PIK3CD PCGF1 other 0.366 3 -1.789 7.30E-05 8.00E-04 AKT1,ATM,AURKB,ETS2,FSH,H2AB3 (includes others),H2AZ1,Histone h2a,MACROH2A1,PCGF1,POU5F1,SETD2,SNAI2 ADAMTS16,ANGPTL3,ANK1,BIRC2,BIRC3,CASP2,CEBPD,CHAC1,FASN,FLNC,GLB1,HNRNPM,HSD3B2,L1CAM,MAPK4,MATR3,MKX,PLG,RRM2,SNAP25 20 (13) 11 camptothecin POU5F1 Histone h2a tolfenamic acid chemical drug 3 -0.651 7.35E-05 1.29E-02 AKT1,APP,BHLHE40,CASP3,CDKN1B,CDKN2A,COP1,DICER1,EIF2AK3,EIF4E,ERK,ERK1/2,ETS2,FADD,GLI1,HIF1A,HNF4A,IGF1,IL10,IL6,IRF3,Jnk,KRT8,MYB,NFATC2,NR1I3,P38 MAPK,PPARGC1A,PRKCE,RICTOR,RXRA,S100A9,SIRT1,STING1,STK11,TNF,tolfenamic acid,TP53,TWIST1 ADGRG6,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ATL2,BBX,BCHE,BIRC2,C1QTNF3,CALCRL,CASP2,CD209,CEBPD,CELSR1,CGAS,CHRNB3,CLEC10A,CLPB,CR1,CSMD3,CYP39A1,DUT,EMILIN2,ETNK1,FAM111A,FASN,FAT4,FCGBP,FGL1,FUT6,GLB1,HCRTR2,HNRNPM,KIFC1,LRP5,MATR3,MEGF10,MKX,NLGN2,PLG,PNLIP,POU3F3,PPP1CA,REG1A,RRM2,RSL24D1,SCARF1,SLC16A4,SVEP1,SYT12,THSD4,TMPRSS6,TNR,TPPP3,TRIM56,TSG101,TULP4 59 (39) 37 ATF2,ATF3,CASP3,caspase sildenafil chemical drug 2 0.626 7.89E-05 1.60E-03 Akt,CFTR,Creb,CYP1A2,ERK1/2,MTORC1,NOS3,PIK3CA,sildenafil,SIRT1,TWIST1 ACAA1,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CACHD1,CEBPD,CELSR1,CLEC10A,CUBN,DPY19L3,FASN,FAT4,FCGBP,GSTM3,HCRTR2,IFI44,L1CAM,PLG,SOD3,TNFSF14,TSG101 23 (11) 10 HMOX1,Na+,K+ -ATPase,VEGFB,VEGFC CASP3,fatty acid,PIK3CA,TRPC6 CHP1 other -0.000 3 -1.050 7.95E-05 2.23E-02 AHR,AKT1,Ap1,APP,Calcineurin protein(s),CEBPA,CHP1,Creb,CREB1,CSF2,CXCL8,ERK1/2,estrogen receptor,Hdac,HIF1A,HNF4A,IL1B,IL6,IRF3,JUN,MAPK14,MAPT,MMP9,Nfat (family),NFATC2,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,P38 MAPK,POU2F2,PPARG,PPARα-RXRα,PPP3R1,RACK1,RAF1,REL,SLC9A1,SMAD3,STAT4,STAT5A,TFEB,TP53 ABCA3,ABCA5,ACAA1,AGA,ALDH7A1,ANK1,ANOS1,AOC1,ASPG,B4GALT1,BBX,BIRC2,BIRC3,C1QTNF3,CALCRL,CALM1 (includes others),CEBPD,CELSR1,CR1,CSMD3,Cyp2d22,CYP39A1,DPY19L3,EMILIN2,FGL1,FLNC,FUT6,GLB1,GNAO1,GSTM3,H2BC21,HNRNPM,HSD3B2,IFI44,KIFC1,L1CAM,LRP4,LRP6,MATR3,MGAT4C,MMRN1,NCAN,POLI,POU3F3,PPP1CA,PTPRK,REG1A,SERINC2,SLC16A4,SLC16A7,SOD3,SYT12,THSD4,TMPRSS6,TNFSF14,TPPP3,TRAF3IP2,TSG101 58 (44) 42 NFkB (complex) VEGFC growth factor 3 -1.250 7.95E-05 9.00E-03 26s Proteasome,AHR,Akt,AKT1,Ap1,APP,CDKN1B,CDKN2A,CREB1,doxorubicin,EIF4E,ERK,ERK1/2,ESR1,ETS2,FADD,FOS,HIF1A,IL10,INSR,IRF3,ITGB1,Jnk,KDR,KRT8,L-tyrosine,MITF,MYC,MYCN,NEDD9,NFATC2,NFkB (complex),NGEF,nitric oxide,NOS3,NR1I3,NRAS,p70 S6k,PDPK1,PGR,PI3K (complex),PLCG1,PPARA,PPARGC1A,PTK2B,RAF1,REL,RICTOR,SHC1,SIRT1,SNCA,SOX2,SPARC,STAT5B,STK11,TNF,TNFSF11,TWIST1,Vegf,VEGFC ADGRG6,ADRM1,AGA,AIMP2,ALDH7A1,ANGPT2,ANOS1,AOC1,BBX,BIRC2,BIRC3,C1QL1,CALM1 (includes others),CD209,CEBPD,CHAC1,CLEC10A,CLPB,CR1,CYP39A1,EMILIN2,ETNK1,FAM111A,FASN,FAT4,FCGBP,FRRS1,GSTM3,HCRTR2,HNRNPM,KMT5A,L1CAM,LRP4,LRP6,MATR3,MEGF11,MGAT4C,MKX,NLGN2,NUBP1,PIF1,PLG,RAB11A,REG1A,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SOD3,SVEP1,SYT12,THSD4,TMPRSS6,TNFSF14,TNXB,TPPP3,TRIM2,TRIM3,TRIM56,TRPM2,TULP4,VPS25 64 (60) 55 CALC,CAMP,prostaglandin E2,sildenafil,tacrolimus,TMPRSS2-ERG,VEGFD 8-bromo-cAMP,MEOX2,rofecoxib,WNT1 AKT1,ITGA4,PROX1 Pam3-Cys chemical toxicant 3 -1.414 8.00E-05 1.06E-02 ACHE,AHR,Akt,Ap1,APP,CDKN1B,CEBPA,COP1,CREB1,CTNNB1,CXCL8,CYP19A1,EGFR,EIF2AK3,EIF4E,ERK,ERK1/2,ESR2,ETS2,FADD,FOS,HIF1A,HNF1A,HNF4A,IFNAR1,IFNG,IGF1,IL10,IL10RA,IL1B,IL4,IRAK1,ITGB1,Jnk,KDM3A,MAPK14,MAPK8,MAPT,MITF,MKNK1,MYB,MYC,MYCN,MYOD1,NFATC2,NFkB (complex),NFKB2,P38 MAPK,Pam3-Cys,PPARA,PPARGC1A,PRKCE,RAF1,RB1,REL,RELA,RICTOR,RPS6KA5,S100A9,SIRT1,STK11,TGFB1,Tlr,TLR2,TNF,TWIST1,Vegf,ZC3H12A ADGRG6,AGA,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,ASPG,ATL2,B4GALT1,BBX,BCHE,BIRC2,BIRC3,C1QTNF3,CACHD1,CALM1 (includes others),CALML3,CD209,CEBPD,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,DGAT1,ETNK1,FAM111A,FASN,FAT4,FUT6,GNAO1,H2AC21,HCRTR2,ITGB3,L1CAM,Lgals6,LRP6,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PIF1,PKD1L2,PLG,PNLIP,RRM2,RRP12,RSL24D1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SNAP25,SOD3,SUSD2,SVEP1,SYT12,THSD4,TMPRSS6,TNFSF14,TNR,TNXB,TPPP3,TRAF3IP2,TRIM56,TULP4,XPO7 72 (68) 64 CXCL10,FPR1,IFNB1,NFkB (complex),POU2AF1 TIRAP FFAR4 G-protein coupled receptor 0.000 3 0.283 8.02E-05 5.10E-03 APP,CASP3,CDKN1B,COP1,DICER1,EIF2AK3,ERK1/2,ETS2,FADD,FFAR4,HIF1A,HRAS,IGF1,IL10,IL1B,IL6,IL6ST,Inflammasome (Nalp3, Asc, Casp1),Insulin,IRF3,Jnk,MYB,NFATC2,NFKB2,NFKBIA,NR1I3,NRAS,P38 MAPK,PDPK1,PPARGC1A,PRKCE,REL,RXRA,S100A9,STAT5B,TNF,TWIST1 AGA,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ATL2,BBX,BCHE,BIRC2,C1QTNF3,CD209,CGAS,CHRNB3,CLEC10A,CLPB,CR1,CYP39A1,EMILIN2,ETNK1,FASN,FAT4,FGL1,HSD3B2,KRT8,LITAF,LRP5,MEGF10,MKX,NCAN,PGK1,PLG,PNLIP,POU3F3,RAB11A,RRM2,SLC5A7,SNAP25,SOD3,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNR,TPPP3,TRAF3IP2,TRIM56,TULP4,VPS25 50 (37) 34 fatty acid Ca2+,IRS1 CASP3,LDL-cholesterol,prostaglandin E2 VAMP2 other 3 -1.257 8.08E-05 1.70E-03 Calcineurin protein(s),CaMKII,Creb,CREB1,DUSP1,ERK,ERK1/2,GRIN3A,L-glutamic acid,MAPK1,MAPK14,Nfat (family),NMDA Receptor,NRAS,NTRK2,P38 MAPK,Pkc(s),SNCA,SRC,Synuclein,VAMP2 ADGRG6,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CALCRL,CEBPD,CHAC1,CLEC10A,DPY19L3,FLNC,HCRTR2,IFI44,ITGB3,KRT8,LITAF,LRP6,MEGF11,MGAT4C,PGK1,PLIN2,PTPRK,RRM2,SERINC2,SNAP25,TNFSF14,TRIM3,TSG101,TULP4,VPS25 31 (21) 18 APPL1 NMDA Receptor mir-326 microRNA 3 0.898 8.24E-05 3.20E-03 Akt,AKT1,CDK2,CEBPA,GADD45A,IL6ST,MAPK14,MAPK8,mir-326,Notch,NOTCH1,NOTCH3,PI3K (complex),PPARG,SREBF1,STAT3,VitaminD3-VDR-RXR ABCA3,ACAA1,AIMP2,ANGPT2,B4GALT1,BIRC2,BIRC3,CD209,CGAS,CLEC10A,DPY19L3,EMX2,FASN,GLB1,HNRNPM,ITGB3,KRT8,L1CAM,LITAF,LRP5,LRP6,MATR3,MMRN1,PGK1,PLG,PLIN2,PTPRK,RRM2,SLC5A7,SNAP25,TNFSF14 31 (17) 16 Notch forskolin chemical toxicant 2 Inhibited -2.213 8.53E-05 1.87E-02 26s Proteasome,Akt,AR,CAV1,CFTR,CNR1,Creb,CREB1,CTNNB1,CXCL8,CYP1B1,DIO2,DUSP1,ERK,ERK1/2,ESR1,ESR2,estrogen receptor,forskolin,FOS,HRAS,IGF1,Jnk,MAPK1,MAPK8,MAPT,NFkB (complex),NFKB1,P38 MAPK,Pkc(s),PPP1R9B,PSEN1,PTPN11,RAF1,RB1,SIRT1,STAT5B,STK11 ABCA3,ACAA1,ADAMTS16,ADGRG6,ADRM1,AIMP2,ALDH7A1,ANK1,AOC1,ASPG,ATL2,B4GALT1,CACHD1,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CLEC10A,CR1,CUBN,Cyp2d22,DGAT1,DPY19L3,DUT,EMX2,FLNC,GLB1,GNAO1,H2BC21,HCRTR2,HSD3B2,KIFC1,KRT8,LITAF,LRP4,LRP6,MAPK4,MEGF10,MGAT4C,MMRN1,NUBP1,PPP1CA,PTPRK,RRM2,RRP12,SERINC2,SLC16A4,SLC16A7,SLC5A7,SNAP25,SUSD2,SYCE2,TENM3,THSD4,TNFSF14,TNXB,TRPM2,TSG101 59 (38) 38 ATF3,BHLHE40,BTG2,Ca2+,CALM1 (includes others),CAMP,CCND2,CDH2,ceramide,CGB3 (includes others),CIDEC,CNN1,CRTC1,CYP27B1,DIO1,DIO2,ESR2,GAST,GRN,HAS2,HMOX1,IGFBP6,IL11,INHA,IRS1,LHB,MAPK7,MGAT3,mir-182,Na+,K+ -ATPase,NPY,NRG (family),PDC,PENK,PGR,PPP1R9B,PROS1,RAP1A,RAPGEF1,RAPGEF3,RPS6KB1,RRM2,SCD,SENP2,Sik1,SLC2A1,SLC5A5,SLC6A3,TAT AKT1,ALDH3A1,CASP3,CDKN2A,FASLG,IFNB1,KRT18,MDM2,mir-145,NFkB (complex),SSTR5,TJP1,USP18 SLC2A1 transporter -0.000 3 -0.544 8.55E-05 7.10E-03 ACHE,Akt,AKT1,Ap1,CASP3,CD3,CDKN1B,CITED2,COP1,DICER1,EGFR,EIF4E,ESR1,ESR2,ETS2,FOS,GSK3B,HIPK2,HNF1A,HNF4A,HRAS,IFNAR1,INSR,IRF3,KLF6,LGALS3,MAPK1,MAPK14,MYB,MYOD1,NGEF,PPARGC1A,PRKCE,PSEN1,RB1,RPS6KA,RXRA,S100A9,SIRT1,SLC2A1,SNCA,SPP1,SRC (family),TGFB1,TWIST1,Vegf ADRM1,AIMP2,ANGPTL3,ANOS1,BBX,BCHE,BIRC3,CALM1 (includes others),CALML3,CEBPD,CGAS,CHAC1,CHRNB3,CLPB,CYP39A1,EMILIN2,FASN,FCGBP,FGL1,FLNC,FUT6,HCRTR2,HNRNPM,IFI44,ITGB3,L1CAM,Lgals6,LRP5,LRP6,MAPK4,MATR3,MEGF10,MEGF11,MKX,MMRN1,NLGN2,NUBP1,PKD1L2,PLG,PRKCSH,PTPRK,RRM2,RRP12,SCARF1,SLC5A7,SVEP1,SYT12,TENM3,TNFSF14,TNXB,TRIM3,TRPM2,TULP4,XPO7 54 (46) 43 2-mercaptoethanol,8-bromo-cAMP,AKT1,APBA3,BHLHE40,carbon tetrachloride,DBH-AS1,deferoxamine,EP300,EPAS1,fatty acid,forskolin,INS,L-triiodothyronine,MSTN,NCOA3,NFkB (complex),NOX4,phenformin,Pi3k class I,SCD,Secretase gamma,sodium azide,SPHK1,SYVN1,tanespimycin,TRPM2,tunicamycin,XDH FFAR1,HNF4A,KT5823,NLRX1,plumbagin,PRKAA1,SENP2,TFAM IgG,sorbitol CASP3,HMOX1,PPARA eflornithine chemical drug 2 0.894 8.58E-05 1.60E-03 AKT1,CDK2,eflornithine,Hdac,MAPK1,MAPK3,RB1 ANGPT2,B4GALT1,BIRC3,CALCRL,CEBPD,CELSR1,EMX2,FLNC,GLB1,H2BC21,HNRNPM,IFI44,ITGB3,LRP4,MAPK4,MATR3,PLG,PTPRK,RRM2,SNAP25 20 (7) 7 AKT1,LGALS3BP,SLC3A2 CASP3 SLK kinase 0.000 3 -0.620 8.63E-05 1.20E-02 AKT1,Ap1,APP,AR,Calcineurin protein(s),CCND3,CDKN1B,CFTR,COP1,Creb,CREB1,CSF2,CTNNB1,CXCL8,CYP19A1,EGFR,EIF2AK3,EIF4E,ERBB2,ESR1,EZR,FADD,FOXO1,HIF1A,HNF1A,HNF4A,HRAS,IGF1,IL2,Jnk,KRT8,MAP3K5,MAPK14,MAPK8,MAPT,MDM2,Mek,MSN,MYC,MYOD1,PDPK1,Plk,PLK1,PPARA,PPARGC1A,PRDM1,PRKCZ,RB1,RHOA,RICTOR,RXRA,S100A9,SIRT1,SLK,SNCA,SPP1,STAT1,STAT4,TGFB1,TNF,TP53,TP73,TWIST1 ABCA3,ANGPTL3,ASPG,ATL2,B4GALT1,BCHE,BIRC3,CALM1 (includes others),CALML3,CASP2,CD209,CEBPD,CHAC1,CLEC10A,CLPB,CR1,CSMD3,CUBN,Cyp2d22,CYP39A1,DGAT1,DPY19L3,EMILIN2,ETNK1,FASN,FAT4,FGL1,FUT6,GSTM3,H2BC21,HCRTR2,HNRNPM,KIFC1,Lgals6,LRP6,MAPK4,MATR3,MEGF11,MGAT4C,NLGN2,PKD1L2,PLG,PNLIP,POU3F3,PPP1CA,PTGIR,RAB11A,REG1A,RRM2,RSL24D1,SERINC2,SLC16A4,SUSD2,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNR,TNXB,TPPP3,TRIM3,TRIM56,TRPM2,TSG101 65 (63) 56 SCD enzyme 3 1.386 8.74E-05 9.20E-03 26s Proteasome,Akt,AKT1,AMPK,Ap1,CASP3,CDKN1B,COP1,CREB1,CTNNB1,DICER1,DLX5,EIF2AK3,EIF4E,ELAVL1,ERK1/2,ESR1,ETS2,FOS,GPAM,HMOX1,HNF4A,HRAS,IFNAR1,IGF1,IL10,INSR,IRF3,IRS1,MITF,MLXIPL,MTOR,MYB,NFATC2,NFKBIA,NGEF,NR1I3,P38 MAPK,PDPK1,PPARA,PPARGC1A,PRKAA,PRKCE,PTPN1,RICTOR,S100A9,SCD,SOX2,SPARC,STAT1,STAT5B,TNFSF11,TSC1,TWIST1,Vegf ADRM1,AGA,AIMP2,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ATL2,BBX,BCHE,BIRC2,BIRC3,C1QL1,CACHD1,CALM1 (includes others),CASP2,CEBPD,CGAS,CHRNB3,CLPB,CR1,CYP39A1,DGAT1,EMILIN2,FASN,FAT4,FCGBP,FRRS1,FUT6,HNRNPM,HSD3B2,ITGB3,L1CAM,LRP4,LRP5,MATR3,MGAT4C,MKX,NCAN,NLGN2,NUBP1,PIF1,PLG,PLIN2,PNLIP,POU3F3,RAB11A,RRM2,RSL24D1,SCARF1,SERINC2,SUSD2,SVEP1,SYT12,TENM3,THSD4,TKFC,TNFSF14,TNR,TRIM2,TRPM2,TULP4 63 (55) 50 4beta-hydroxycholesterol,ACSS2,arginine,carbohydrate,CIDEC,D-fructose,ESR2,FGF4,FGF7,forskolin,FOXO4,ghrelin,GW3965,JINK1/2,L-cysteine,LG100268,PPP3R1,PTN,sucrose,tolylfluanid 25-hydroxycholesterol,CDN1163,CNTF,DYSF,ERN1,FGF19,GDF2,HOXA10,INS,L-triiodothyronine,LOC102724428/SIK1,manassantin B,Map3k7,MAP4K4,miR-217-5p (and other miRNAs w/seed ACUGCAU),N-cor,OSMR,POR,SFRP1,SIRT,SLC39A14,sphingomyelin,tanespimycin,tofogliflozin,TRIB1,xanthohumol ceramide,DIO1,gamma-linolenic acid,palmitoyl-coenzyme A,PEMT,SLC2A1,VLDL AKT1,ANGPTL4,ATF3,bile acid,CASP3,CXCL10,IRS1,RBP1,S100A9,SAA1 EP300 transcription regulator 0.000 3 -1.013 8.79E-05 2.93E-02 26s Proteasome,AKT1,Ap1,APP,AR,ATF2,ATF4,ATM,BCL6,BHLHE40,BTK,CDK9,CHEK2,CREBBP,CRTC2,CXCL8,CYP1A2,E2F3,EGFR,EIF2AK3,EIF4E,ELF3,EP300,ESR1,estrogen receptor,ETV1,FADD,FOS,FOXA1,FOXA2,GATA4,GATA6,HCFC1,HIF1A,HIPK2,HNF1A,HNF4A,IGF1,IKZF1,IL1B,JUN,JUNB,KMT2A,L-triiodothyronine,MAP3K1,MDM2,MEF2C,mir-21,MYOD1,NCAM1,NEUROD1,NFE2L2,NFkB (complex),NR1I2,PPARG,PPIF,REL,SMARCA4,SOX2,SP1,STAT3,STAT5B,T3-TR-RXR,TCF,TCF4,TNF,TP53,transcription factor,VDR,VitaminD3-VDR-RXR ACAA1,ADGRG6,ADRM1,AGA,AKNA,ALDH7A1,ANGPT2,ANK1,ATL2,B4GALT1,C1QL1,CACHD1,CALCRL,CALM1 (includes others),CASP2,CD209,CEBPD,CELSR1,CHAC1,CLEC10A,CLPB,CR1,CSMD3,CUBN,Cyp2d22,CYP39A1,DGAT1,DUT,EMX2,ETNK1,Fcna,FLNC,FUT6,GLB1,GSTM3,H2BC21,HNRNPM,HSD3B2,IFI44,ITGB3,KIFC1,KMT5A,L1CAM,Lgals6,LITAF,LRP4,LRP5,MATR3,MKX,NANOS1,NLGN2,NUBP1,PGK1,PIF1,PKD1L2,PLG,PLIN2,PNLIP,POLI,POU3F3,PPP1CA,SCARF1,SLC16A4,SNAP25,SOD3,SSPOP,SYT12,TENM3,TMPRSS6,TNXB,TPPP3,TRAF3IP2,TRIM2,TRIM36,TRIM56,TRPM2,TSG101,WRN,XPO7 79 (70) 57 AKT1,Beta Arrestin,Ca2+,HIPK2,PRKAA1,WNT5A dorsomorphin,EBF1 ACHE,Ahr-aryl hydrocarbon-Arnt,ATF2,BDKRB2,CAV3,CD19,CDKN2A,ETV1,GAST,HCFC1,HMOX1,HNF4A,INS,KDM3A,LHB,MDM2,MME,MMP7,NFkB (complex),PGR,PPARA,SLC2A1,TERT,TFAM CASP3,caspase,MMD ETV1 transcription regulator -0.000 3 0.218 8.79E-05 1.10E-03 CTNNB1,EIF4EBP1,ETV1,IRF3,NOS3,RB1,TERT ACAA1,ANGPT2,ANOS1,BIRC2,BIRC3,CALCRL,CEBPD,CELSR1,EMX2,FASN,GLB1,H2BC21,IFI44,ITGB3,KIFC1,L1CAM,MAPK4,PGK1,PLIN2,SOD3,SUSD2 21 (7) 7 EP300,MRAS,NCOA3 MMP7,TERT 6-hydroxydopamine chemical toxicant 3 0.516 8.88E-05 6.90E-03 26s Proteasome,6-hydroxydopamine,ACHE,Akt,AKT1,AMPK,APP,ATF4,CAMK2A,CASP3,CAT,CEBPA,CREB1,CXCL8,DICER1,DLX5,EIF2AK3,EIF4E,ERN1,ESR2,ETS2,FAAH,FOS,Gsk3,HNF4A,HRAS,hydrogen peroxide,IGF1,IL6,Jnk,JUN,MAFB,MAP3K5,MAPK1,MAPK10,MITF,MLXIPL,MYB,MYC,NFkB (complex),NFKB2,NGEF,NR1I2,P38 MAPK,PAWR,PDPK1,PPARA,PRKCD,PRKCE,RAF1,REL,RELA,RICTOR,S100A9,SHC1,SIRT1,SOX2,SPARC,TGFB1,TNFSF11 ADRM1,AGA,AIMP2,ALDH7A1,ANK1,ATL2,B4GALT1,BCHE,BIRC3,C1QL1,C1QTNF3,CALML3,CD209,CHAC1,CHRNB3,CLEC10A,CR1,CYP39A1,DGAT1,FGL1,FLNC,FRRS1,FUT6,HCRTR2,HNRNPM,IFI44,ITGB3,L1CAM,LRP4,LRP5,MATR3,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PIF1,PLIN2,PNLIP,POLI,POU3F3,PRKCSH,PTGIR,PTPRK,RAB11A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A7,SLC5A7,SOD3,TENM3,THSD4,TKFC,TNFSF14,TPPP3,TRIM2,TULP4 60 (60) 50 AKT1,anandamide,ASCC1,CASP3,caspase,ERN1,iron,MAP3K11,MDM2,NFkB (complex),NOX1,NPY,PENK prostaglandin E2,SLC6A3 SPHK1 kinase 2 -1.859 9.11E-05 8.70E-03 Akt,AKT1,Ap1,Ca2+,CHUK,CTNNB1,EIF4EBP1,ERK,ERK1/2,ERN1,HRAS,IKBKB,JUN,MAPK1,MAPK3,MAPK8,NFkB (complex),NFKBIA,nitric oxide,NRAS,P38 MAPK,SPHK1 ACAA1,ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CALCRL,CALM1 (includes others),CEBPD,EMX2,FLNC,HNRNPM,IFI44,ITGB3,KIFC1,LITAF,MATR3,NCAN,PGK1,PLG,POLI,PTPRK,RRM2,SLC16A4,SOD3,SUSD2,TENM3,TNFSF14,TSG101,TULP4,VPS25 35 (22) 22 carbon tetrachloride,EPAS1,G Protein I,IL11,LPAR1,Map3k7,N,N-dimethylsphingosine,phorbol 12,13-dibutyrate,phytohemagglutinin,PLD1 CISH,ESR2,etoposide,infliximab,NADH,oleic acid,onapristone AKT1,Ca2+,NFkB (complex),SLC2A1,TRAF1 CASP3,CDKN2A,ceramide,ERN1,RPS6KB1,SOCS3 TRAF1 other -0.000 3 -1.250 9.32E-05 1.64E-02 Ap1,APP,AR,Calcineurin protein(s),CASP8,CDKN1B,CEBPA,Creb,CREB1,CTNNB1,CYP19A1,EGFR,EIF2AK3,EIF4E,ELAVL1,ERK1/2,ESR1,ESR2,ETS2,FADD,FOS,FOXA1,FOXA2,HIF1A,IFN Beta,IL10,IL6,ITGB1,Jnk,JUN,MAPK1,MAPK8,MAPT,Mek,MITF,MKNK1,MYC,NFATC2,NFKB1,NR1I3,PAK2,PGR,PPARA,RAF1,RICTOR,RXRA,SIRT1,STK11,TCF4,TCF7L2,TFAM,TICAM1,TNF,TP53,TRAF1,transcription factor,TWIST1 ANGPT2,ANGPTL3,AOC1,ASPG,B4GALT1,BBX,BIRC2,BIRC3,CACHD1,CALM1 (includes others),CASP2,CD209,CEBPD,CGAS,CLEC10A,CLPB,CR1,CSMD3,Cyp2d22,CYP39A1,DGAT1,DPY19L3,ETNK1,FAM111A,FASN,FAT4,FGL1,FLNC,GNAO1,GSTM3,HCRTR2,ITGB3,KIFC1,KMT5A,MEGF10,MGAT4C,MKX,MMRN1,NANOS1,NLGN2,NUBP1,PIF1,PLG,PNLIP,POLI,POU3F3,PPP1CA,RRP12,RSL24D1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SUSD2,THSD4,TMPRSS6,TNR,TNXB,TPPP3,TRIM2,TRIM56,TRPM2,TSG101,WRN 64 (57) 54 bryostatin 1,camptothecin,phytohemagglutinin,SPHK1 gambogic acid,indole-3-carbinol,infliximab,lonafarnib,MEOX2,noscapine,RPSA,salinosporamide A,zerumbone IFNB1 CCNE1 transcription regulator -0.000 3 -1.576 9.46E-05 1.57E-02 APP,AR,ATF4,CASP3,CCNB1,CCNE1,CDK1,CDK2,CDK6,CDKN1B,CREB1,DICER1,E2f,E2F1,EIF2AK3,EIF2AK4,EIF4E,ETS2,FOS,FOXM1,HIF1A,HRAS,ID2,MAPT,MYB,MYBL2,MYC,NFKBIA,NPM1,NR1I2,POU5F1,PPARGC1A,RB1,RBL2,SIRT1,SMARCA4,SOX2,SREBF2,STING1,TSC1 ABCA3,AGA,AIMP2,ANGPT2,ANGPTL3,ASPG,BIRC2,BIRC3,C1QL1,CALCRL,CASP2,CEBPD,CELSR1,CGAS,CHAC1,CLPB,Cyp2d22,CYP39A1,EMILIN2,EMX2,FASN,GLB1,H2BC21,HCRTR2,HSD3B2,IFI44,ITGB3,KIFC1,LGMN,LRP4,LRP5,MAPK4,MEGF10,MGAT4C,MKX,NCAN,NLGN2,NUBP1,PGK1,PNLIP,POU3F3,REG1A,RRM2,SERINC2,SLC16A4,SLC16A7,SNAP25,SOD3,SVEP1,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TPPP3,TRIM36,TULP4,WRN 58 (40) 34 AKT1,ammonium,CCND2,DBH-AS1,deferoxamine,E2F2,ESR2,Fc gamma receptor,L-triiodothyronine,LIF,MIR17HG,NCOA3,PIK3CD,PPARD,PROX1,RPS6KB1,TFF2,VTCN1 3',4',7-trihydroxyisoflavone,ATF3,BTG2,caffeic acid phenethyl ester,CDKN2A,HMOX1,INHA,iron,KRT10,PCGF2,PPARA,vatalanib CASP3,POU5F1 anisomycin chemical - endogenous non-mammalian 2 -0.745 9.56E-05 1.18E-02 anisomycin,Ap1,APP,BCL2,CREB1,EIF4E,ERK,ERK1/2,Jnk,JUN,MAPK1,MAPK14,MAPK3,MAPK8,MAPK9,MAPT,MDM2,MYB,MZF1,NFKB1,NR4A1,P38 MAPK,PDPK1,PPARG,STAT1,TP53,WWOX ACAA1,ADGRG6,ANGPT2,ANK1,AOC1,ASPG,B4GALT1,CALCRL,CALM1 (includes others),CASP2,CD209,CELSR1,CLEC10A,CSMD3,DGAT1,DUT,FLNC,GLB1,GNAO1,GSTM3,H2BC21,HSD3B2,ITGB3,KIFC1,LITAF,LRP6,MEGF10,MGAT4C,NLGN2,PGK1,PLG,POLI,POU3F3,PPP1CA,PTPRK,RAB11A,SERINC2,SNAP25,SOD3,THSD4,TPPP3,TRIM2,TSG101,TULP4,WRN 45 (27) 26 ATF2,ATF3,CASP3,caspase,FASLG,IRS1,MAP3K10,MDM2,RPS6KB1,Sapk,TERT Ca2+,DUSP8 VAV1 transcription regulator -0.000 3 -0.593 9.70E-05 1.13E-02 26s Proteasome,Akt,AKT1,Ap1,APP,BTK,CDC42,CHUK,CREB1,CTNNB1,CXCL8,EIF2AK3,EIF4E,ELAVL1,EPAS1,ERK,ERK1/2,ESR1,ETS2,FADD,FGF2,FOS,HIF1A,HNF1A,HNF4A,HRAS,IFNAR1,IGF1,IKZF1,IL10,IL1B,IL2,IRF3,Jnk,JUN,MAPK1,MAPK14,MAPK3,MAPK8,MITF,MYC,MYCN,MYOD1,Nfat (family),NFATC1,NFkB (complex),NFKB1,NFKB2,NGEF,NRAS,Pak,PDPK1,PI3K (complex),PLC gamma,PLCG2,PPARA,PPARGC1A,PRKD1,PTK2B,Rac,RAC1,RAC2,RAF1,REL,RHOA,RICTOR,S100A9,SIRT1,SNCA,SOX2,SPARC,SRF,STK11,TCF7L2,TEC,TNF,TNFSF11,VAV1 ADGRG6,ADRM1,AGA,AIMP2,ALDH7A1,ANGPT2,ANOS1,AOC1,ATL2,B4GALT1,BCHE,BIRC3,C1QL1,C1QTNF3,CACHD1,CALCRL,CALM1 (includes others),CD209,CGAS,CHAC1,CLEC10A,CR1,DGAT1,ETNK1,FLNC,FRRS1,FUT6,GNAO1,HCRTR2,HNRNPM,IFI44,ITGB3,KMT5A,L1CAM,Lgals6,LRP5,LRP6,MATR3,MEGF11,MGAT4C,MKX,NLGN2,NUBP1,PIF1,PKD1L2,PLG,PNLIP,POLI,PTGIR,PTPRK,RAB11A,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SOD3,SUSD2,SVEP1,TENM3,THSD4,TMPRSS6,TNFSF14,TPPP3,TRAF3IP2,TRIM2,TRIM3,TRIM56,TRPM2,VPS25 71 (78) 64 CD19,CNTF,CR1L,CRKL,FGR,PDK1 KLRC4-KLRK1/KLRK1 AKT1,CCND2,IgG,NFkB (complex),Pak,PLC gamma,RAC2,RHOG peroxynitrite chemical toxicant 3 -0.970 9.73E-05 5.10E-03 26s Proteasome,Akt,AKT1,AMPK,APP,ATF4,beta-estradiol,CASP3,CDKN1B,CFTR,CITED2,CYP19A1,DICER1,doxorubicin,EGFR,EIF4E,ELAVL1,EPAS1,ERK1/2,ETS2,FADD,FOS,HIF1A,HNF1A,HNF4A,IFNAR1,IKK (complex),IL1B,MAP2K1,MAP2K4,Mapk,MAPK1,MAPK14,MAPK8,MAPT,MITF,MLXIPL,Mmp,MYB,MYOD1,NEDD9,NFATC2,NFkB (complex),NFKB1,NGEF,NOS3,peroxynitrite,Ppp2c,PRKAA1,PRKCZ,PRKG1,PTPN1,RAF1,RCAN1,RGS4,RICTOR,S100A9,SLC6A3,SMARCA4,SNCA,SOX2,SPARC,STK11,TGFB1,TNF,TNFSF11,TPH1,TRPV1 ADRM1,AIMP2,ALDH7A1,ANGPT2,AOC1,ASPG,B4GALT1,BBX,BCHE,BIRC2,BIRC3,C1QL1,CACHD1,CALML3,CASP2,CD209,CEBPD,CGAS,CHAC1,CLPB,CUBN,DGAT1,DUT,ETNK1,FAM111A,FLNC,FRRS1,FUT6,GNAO1,H2BC21,HNRNPM,HSD3B2,IFI44,ITGB3,KMT5A,L1CAM,Lgals6,LGMN,LITAF,LRP4,LRP5,LRP6,MATR3,MEGF6,MKX,NLGN2,NUBP1,PGK1,PIF1,PKD1L2,PLG,PTPRK,RSL24D1,SCARF1,SLC16A4,SLC16A7,THSD4,TKFC,TMPRSS6,TNFSF14,TNXB,TPPP3,TRAF3IP2,TRIM2,TRIM3,TRIM36,TRIM56,TULP4 68 (68) 57 N,N-dimethylarginine propofol AKT1,CASP3,iron,NFkB (complex),PRKAA1 SLC6A3 MOG other 3 0.962 1.04E-04 2.10E-02 AHR,Akt,AKT1,Ap1,CEBPA,CSF2,CXCL8,cytokine,ERK,estrogen receptor,GNB1,HIF1A,HNF4A,IL1B,IL6,IRF3,JUN,MAPK14,MHC II,MOG,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,POU2F2,PPARG,PPARα-RXRα,REL,SMAD3,STAT1,STAT4,STAT5A,TP53 ABCA3,ACAA1,ADGRG6,AGA,AIMP2,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CLEC10A,CR1,CSMD3,Cyp2d22,CYP39A1,EMILIN2,FGL1,FLNC,FUT6,GLB1,GNAO1,GSTM3,H2BC21,HNRNPM,HSD3B2,IFI44,KIFC1,L1CAM,LITAF,LRP6,MATR3,MMRN1,NCAN,POLI,PPP1CA,PTPRK,REG1A,SLC16A4,SOD3,SYT12,TMPRSS6,TNFSF14,TRAF3IP2,TSG101 53 (34) 31 4-phenylbutyric acid,PPARD CCL3L3,CXCL10,IL27,NFkB (complex) PGR ligand-dependent nuclear receptor 3 Inhibited -2.566 1.08E-04 1.34E-02 AHR,Akt,Alpha catenin,APP,AR,CDKN1B,CREB1,CTNNB1,EIF4E,ERK1/2,estrogen receptor,FOXA1,GRIN3A,HIPK2,HNF4A,HRAS,IL1B,IL6,IRF3,MAPT,mir-21,MITF,MMP2,NCOA1,NEDD9,Nfat (family),NFkB (complex),NFKB2,NR5A2,PGR,PPARD,PRKCE,promegestone,PTK2,PTPRJ,REL,RUNX3,SMAD2,SNCA,SOX2,SRC,SRC (family),STAT1,STAT3,STAT4,STAT5B,TCF4,TCF7L2,TGFB1,transcription factor,VDR,VitaminD3-VDR-RXR,WBP2,WWOX ACAA1,ADRM1,AGA,ALDH7A1,ANOS1,AOC1,ASPG,B4GALT1,BBX,BIRC2,BIRC3,C1QL1,C1QTNF3,CALML3,CASP2,CD209,CEBPD,CHAC1,CHRNB3,CLPB,CUBN,Cyp2d22,CYP39A1,EMILIN2,EMX2,FAM111A,FASN,FCGBP,FGL1,FLNC,FUT6,GSTM3,HCRTR2,HSD3B2,IFI44,ITGB3,KIFC1,KMT5A,KRT8,L1CAM,LRP4,LRP5,MEGF11,MGAT4C,MMRN1,NANOS1,NLGN2,PIF1,PLG,PLIN2,PNLIP,POU3F3,REG1A,RRM2,SNAP25,SOD3,SUSD2,SVEP1,TENM3,THSD4,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM2,TRIM3,XPO7 67 (54) 48 8-bromo-cAMP,alpha-estradiol,EP300,FGR,forskolin,L-triiodothyronine,lead,MAP3K8,NCOA3,NR5A2,PAK2 CALM1 (includes others),CDK2AP1,cerivastatin,ESR2,GPS2,Hsp90,LIF,NR0B1,onapristone,RAD51C,TAOK2 ACSL1,CCN5,DSCAM,EPAS1,MFAP5,MTSS1,NET1,NQO2,PDLIM1,PIP5K1B,TGFBI,TSC22D3 IRS1,LHB,NFkB (complex) radical chemical - other 3 0.962 1.08E-04 2.19E-02 AHR,AKT1,Ap1,CASP9,CCND1,CEBPA,CSF2,CXCL8,cytokine,estrogen receptor,HIF1A,HNF4A,IKBKB,IL1B,IL6,IRF3,JUN,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,PAK2,POU2F2,PPARG,PPARα-RXRα,radical,REL,SMAD3,SP1,STAT1,STAT4,STAT5A,TP53 ABCA3,ACAA1,AGA,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CLEC10A,CR1,CSMD3,Cyp2d22,CYP39A1,EMILIN2,FGL1,FLNC,FUT6,GLB1,GNAO1,GSTM3,H2BC21,HNRNPM,HSD3B2,IFI44,ITGB3,KIFC1,L1CAM,LITAF,LRP6,MATR3,MMRN1,NCAN,PGK1,POLI,PPP1CA,PTPRK,REG1A,SLC16A4,SOD3,SYT12,TMPRSS6,TRAF3IP2,TSG101,WRN 53 (34) 32 1-methyl-4-phenylpyridinium,Ca2+,NMDA Receptor,NOX4 Hsp90,Trolox C NFkB (complex) DBH-AS1 other 3 -1.152 1.14E-04 1.72E-02 AKT1,Alpha catenin,Ap1,APP,CEBPA,COP1,Creb,CREB1,CTNNB1,CYP19A1,DBH-AS1,EGFR,EIF4E,ERK,ESR1,FADD,FOS,IGF1,IRF3,Jnk,JUN,KAT5,KRT8,MAPT,MITF,MYB,NFATC2,NFKBIA,P38 MAPK,PGR,PPARA,PPARGC1A,RB1,RICTOR,RXRA,S100A9,SIRT1,TCF7L2,TNF,TWIST1,VDR,Wnt,WNT3A,WNT5A ACAA1,ADGRG6,ANGPTL3,ANK1,ANOS1,ASPG,ATL2,BBX,BCHE,BIRC3,C1QTNF3,CALM1 (includes others),CD209,CEBPD,CLEC10A,CSRNP3,CUBN,DPY19L3,EMILIN2,EMX2,ETNK1,FAM234B,FASN,FAT4,FCGBP,GSTM3,H2BC21,HCRTR2,HNRNPM,ITGB3,KIFC1,KMT5A,L1CAM,LITAF,LRP5,MAPK4,MATR3,MEGF10,MGAT4C,MMRN1,NLGN2,NUBP1,PGK1,PIF1,PLG,PLIN2,POLI,POU3F3,REG1A,RSL24D1,SERINC2,SUSD2,SVEP1,SYT12,THSD4,TNR,TNXB,TPPP3,TRIM56,TRPM2,TULP4 61 (44) 42 CCNE1,SLC2A1 CDKN2A PPP5C phosphatase -0.000 3 -0.372 1.18E-04 1.89E-02 26s Proteasome,APP,ATM,BHLHE40,CDKN1B,CDKN2A,CHEK2,COP1,E2F3,EGFR,EIF2AK3,EIF4E,ERK1/2,ESR1,ETS2,FADD,FASN,GLI1,Hdac,HIPK2,HNF4A,HRAS,IL10,IL2,IL6,IRF3,ITGB1,Jnk,JUN,KRT8,MAP2K4,MAP3K5,MAPK8,MAPT,MYOD1,NFATC2,NR1I3,NR3C1,PDPK1,PPARG,PPARGC1A,PPP5C,PRKCE,PRKDC,progesterone,RAF1,RICTOR,RXRA,SIRT1,SMARCA4,STAT5B,TGFB1,TNF,TP53,TSG101,TWIST1 ACAA1,ADRM1,AKNA,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ASPG,B4GALT1,BBX,BIRC3,C1QTNF3,CALCRL,CALML3,CASP2,CD209,CELSR1,CHRNB3,CLEC10A,CLPB,CR1,CSMD3,CYP39A1,DGAT1,DUT,EMILIN2,ETNK1,FAM111A,FASN,FAT4,FGL1,FUT6,GLB1,HCRTR2,KIFC1,Lgals6,LRP4,MKX,NLGN2,PLG,PLIN2,PNLIP,POLI,POU3F3,PPP1CA,PTGIR,RAB11A,REG1A,RRM2,RSL24D1,SCARF1,SLC16A7,SVEP1,SYT12,TENM3,THSD4,TNR,TNXB,TPPP3,TRIM36,TRIM56,TRPM2,TSG101,XPO7 65 (56) 52 lactacystin lead MDM2 ANXA4 other -0.000 3 0.577 1.19E-04 1.59E-02 AHR,ANXA4,Ap1,arachidonic acid,ATF4,CCND1,CEBPA,Creb,CREB1,CSF2,CTNNB1,CXCL8,cytokine,estrogen receptor,HIF1A,HNF4A,IKBKB,IL1B,IL6,IRF3,JUN,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,PLA2,PLA2G2A,POU2F2,PPARGC1A,REL,SMAD3,SP1,STAT1,STAT4,STAT5A ABCA3,AGA,ALDH7A1,ANGPT2,ANGPTL3,ANOS1,AOC1,ASPG,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALM1 (includes others),CD209,CEBPD,CHAC1,CLEC10A,CR1,Cyp2d22,CYP39A1,DPY19L3,FGL1,FLNC,FUT6,GNAO1,GSTM3,H2BC21,HSD3B2,IFI44,ITGB3,L1CAM,LITAF,LRP6,MGAT4C,MMRN1,NCAN,POLI,PTPRK,REG1A,RRM2,SERINC2,SLC16A4,SOD3,SUSD2,SVEP1,SYT12,TMPRSS6,TRAF3IP2 48 (36) 34 RGS4 NFkB (complex) apicularen A chemical reagent 3 -0.135 1.20E-04 2.27E-02 AHR,Ap1,apicularen A,CCND1,CEBPA,CSF2,CXCL8,cytokine,estrogen receptor,FOS,HIF1A,HNF4A,IGF1,IKBKB,IL1B,IL2,IL6,IRF3,Nfat (family),NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,POU2F2,PPARG,PPARα-RXRα,REL,SMAD3,SP1,STAT1,STAT4,TP53 ABCA3,ACAA1,AGA,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,ATL2,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CGAS,CLEC10A,CR1,CSMD3,Cyp2d22,CYP39A1,EMILIN2,FGL1,FLNC,FUT6,GLB1,GNAO1,GSTM3,H2BC21,IFI44,ITGB3,KIFC1,L1CAM,LITAF,LRP6,MMRN1,NCAN,NUBP1,PGK1,PPP1CA,PTGIR,PTPRK,REG1A,RRM2,SLC16A4,SOD3,SYT12,THSD4,TMPRSS6,TNFSF14,TRAF3IP2,TSG101 55 (33) 32 GRN,JINK1/2,NFkB (complex) bile acid chemical - endogenous mammalian 3 -0.620 1.21E-04 1.11E-02 ACHE,AGT,Akt,Ap1,APP,bile acid,caspase,CDKN1B,CEBPA,CREB1,CX3CR1,EIF4E,ELAVL1,ERK1/2,ESR2,ETS2,FADD,FGF19,FGFR2,FOS,FOXA1,GCG,GNE,Gpcr,HIF1A,HNF4A,HRAS,IGF1,IL2,INSR,IRF3,JINK1/2,Jnk,JUN,mir-21,MITF,Mmp,MYB,MYC,NFKB1,NGEF,NR0B2,NR1H4,NR1I2,NR5A2,NRAS,P38 MAPK,Pkc(s),PPARGC1A,PRKCE,RAF1,RB1,RICTOR,RXFP2,S100A8,S100A9,SLC18A3,STAT3,STK11,TNF,TNFSF11,trypsin,TWIST1,VDR AIMP2,ANGPT2,ANK1,ANOS1,AOC1,ATL2,BCHE,BIRC3,CACHD1,CALM1 (includes others),CD209,CEBPD,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CUBN,CYP39A1,EMILIN2,ETNK1,FAT4,FCGBP,FRRS1,FUT6,GNAO1,GSTM3,ITGB3,KRT8,L1CAM,LRP5,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PGK1,PIF1,PLG,PLIN2,PNLIP,POLI,PPP1CA,PTGIR,RRM2,RRP12,RSL24D1,SCARF1,SLC16A4,SLC16A7,SLC5A7,SOD3,SSPOP,SVEP1,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TRIM2,TRIM3,TRIM56,VPS25 65 (64) 57 ATF3,Ca2+,CREB3L3,POR,taurocholic acid FGFR4,PPARA,S-adenosylmethionine,SCD,SCP2 caspase,DIO2,JINK1/2,NR5A2,tauroursodeoxycholic acid tiron chemical reagent 2 1.279 1.22E-04 1.60E-03 Akt,ATF4,ATF6,Jnk,MAPK1,MAPK8,P38 MAPK,SRC,tiron AIMP2,ANGPTL3,ANK1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CHAC1,CLEC10A,DGAT1,FASN,FLNC,IFI44,ITGB3,L1CAM,PGK1,PLG,PLIN2,PTPRK,RRM2,TNFSF14 22 (9) 8 HMOX1 nelfinavir chemical drug 2 0.626 1.24E-04 1.20E-03 26s Proteasome,Akt,AKT1,AR,CDK2,CYP1A2,nelfinavir ADRM1,AIMP2,AKNA,BIRC2,BIRC3,CACHD1,CEBPD,CHAC1,Cyp2d22,DGAT1,FASN,GSTM3,HNRNPM,HSD3B2,L1CAM,MATR3,MEGF10,PLG,RRM2,SNAP25,SOD3,SSPOP,TNFSF14 23 (7) 7 ATF3,HMOX1,PPP1R15A,RNF41,TSC22D3 AKT1 WNT1 cytokine -0.000 3 0.485 1.24E-04 2.85E-02 26s Proteasome,ACHE,AHR,Akt,Ap1,APP,BHLHE40,CASP3,CDKN2A,CHEK2,CSNK2A2,CTNNB1,CXCL8,DICER1,DLX5,E2F3,EIF2AK3,EIF4E,ESR1,ESR2,FOS,GSK3B,HIPK2,HMOX1,HRAS,IL10,IL1B,IL6,INSR,IRF3,KLF6,LEF1,LGALS3,MAP3K7,MAPT,MYOD1,NFkB (complex),NGEF,NLK,NR1I2,NRAS,PDPK1,PI3K (complex),PPARGC1A,PRKCE,RB1,RBPJ,REL,RHOA,SNCA,STING1,TCF7L2,TERT,TP53,TWIST1,Vegf,WNT1 ACAA1,ADRM1,AGA,AIMP2,AKNA,ALDH7A1,ANGPT2,ANGPTL3,ANK1,ANOS1,ASPG,B4GALT1,CALCRL,CALM1 (includes others),CASP2,CEBPD,CELSR1,CGAS,CHAC1,CHRNB3,CR1,CSMD3,CYP39A1,DUT,EMX2,FAM111A,FAT4,FCGBP,FGL1,GLB1,GNAO1,H2BC21,IFI44,KMT5A,Lgals6,LRP5,MAPK4,MEGF10,MEGF11,NLGN2,NUBP1,PGK1,PLG,PLIN2,PNLIP,POU3F3,PPP1CA,PRKCSH,RAB11A,RRM2,RRP12,SCARF1,SLC5A7,SOD3,SUSD2,SVEP1,SYT12,TENM3,THSD4,TNFSF14,TPPP3,TRAF3IP2,TRIM3,TRPM2,TSG101,TULP4,VPS25,XPO7 68 (57) 48 miR-34a-5p (and other miRNAs w/seed GGCAGUG),SFRP2 CCN5,CDKN2A,CDX1,DVL1,Frizzled,LRP6,MAP3K7,MRAS,NFkB (complex),prostaglandin E2,TERT,TFF2,TJP1 CASP3,RELN,VEGFC PROCR other 3 -1.722 1.25E-04 9.60E-03 ACHE,Akt,ATF4,CDKN1B,CDKN2A,COP1,Creb,EGFR,ELAVL1,ERK,ERK1/2,ESR1,ESR2,ETS2,F2R,FLCN,FOS,GSK3B,HIPK2,HNF1A,HNF4A,IFNAR1,IGF1,IL10,INSR,ITGB1,KRT8,LGALS3,MAPK14,Mek,MYB,MYOD1,NFATC2,NFKB2,NGEF,P38 MAPK,p70 S6k,PPARGC1A,PRKAA1,PRKCE,PROC,PROCR,PSEN1,RB1,RXRA,S100A9,SNCA,SRC (family),TCF7L2,TWIST1 ADGRG6,AGA,AIMP2,ANGPT2,ANGPTL3,ANK1,AOC1,ATL2,BBX,BCHE,C1QTNF3,CACHD1,CASP2,CEBPD,CGAS,CHAC1,CHRNB3,CLPB,CR1,DPY19L3,EMILIN2,FAM111A,FAT4,FCGBP,FGL1,FUT6,H2BC21,HSD3B2,IFI44,ITGB3,KMT5A,KRT8,L1CAM,Lgals6,LITAF,LRP6,MAPK4,MEGF10,MEGF11,MKX,NUBP1,PKD1L2,PLG,PRKCSH,REG1A,RRM2,RRP12,SCARF1,SLC5A7,SVEP1,SYT12,TNFSF14,TNXB,TRIM3,TRPM2,TULP4,XPO7 57 (50) 47 BHLHE40,HMOX1,WNT3A CCN5 ANGPT1,LIF,PRKAA1,TJP1 F10 TPOR dimer complex 3 -1.543 1.26E-04 1.35E-02 Akt,AKT1,BCL2,CDKN1B,CTNNB1,EGFR,ERBB2,ERK,ERK1/2,HOXA10,HRAS,IFNGR1,IL6ST,Insulin,IRF3,IRS,IRS2,JAK2,Jnk,LEPR,MPL,NFKBIA,NRAS,P38 MAPK,Pkc(s),PLC gamma,PTPN11,RAF1,REL,SHC1,SP1,STAT4,STAT5A,STAT5B,TPOR dimer ABCA3,ACAA1,ADGRG6,AGA,AIMP2,ANK1,ANOS1,AOC1,ARL6IP4,BCHE,CALCRL,CGAS,CLEC10A,CLPB,Cyp2d22,CYP39A1,DGAT1,DPY19L3,DUT,FASN,HNRNPM,HSD3B2,KIFC1,KRT8,L1CAM,LGMN,LITAF,MATR3,MMRN1,NCAN,PLG,PLIN2,POLI,SLC16A7,SLC5A7,SNAP25,SUSD2,TENM3,TNFSF14,TNXB,TULP4,VPS25 42 (35) 30 PLC gamma TNFSF4 cytokine 3 0.429 1.26E-04 2.02E-02 AHR,Akt,Ap1,CEBPA,CSF2,CXCL8,cytokine,estrogen receptor,HIF1A,HNF4A,IL6,IRF3,JUN,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,POU2F2,PPARG,PPARα-RXRα,REL,SMAD3,STAT1,STAT4,STAT5A,TNFRSF4,TNFSF4,TP53 ABCA3,ACAA1,AGA,AIMP2,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CLEC10A,CR1,CSMD3,Cyp2d22,CYP39A1,EMILIN2,FGL1,FLNC,FUT6,GLB1,GNAO1,GSTM3,H2BC21,HSD3B2,IFI44,KIFC1,LITAF,LRP6,MMRN1,NCAN,PGK1,POLI,PPP1CA,PTPRK,REG1A,SLC16A4,SOD3,SYT12,TMPRSS6,TNFSF14,TSG101 49 (29) 27 DETA-NONOate,KLRC4-KLRK1/KLRK1,POU5F1 MEOX2 IgG MK2206 chemical drug 3 1.633 1.29E-04 1.02E-02 Akt,AKT1,AKT2,Alpha catenin,APP,ARNTL,CDKN2A,CEBPA,CHEK1,CLOCK,CTNNB1,DLX5,E2F3,ERK,ERK1/2,FOS,FOXO3,FSH,Gsk3,GSK3B,H2AB3 (includes others),Histone h2a,HMOX1,HRAS,IL10,KLF6,LGALS3,MAFB,MITF,MK2206,MTOR,MYB,NGEF,NOS1,NR1I3,p70 S6k,PDPK1,PPARGC1A,RICTOR,RXRA,SETD2,SIRT1,SOX2,SPARC,TCF7L2,TNF,TNFSF11,TWIST1,VDR,Wnt,WNT5A ACAA1,ADAMTS16,ADGRG6,ADRM1,AIMP2,AKNA,ANGPT2,ANGPTL3,AOC1,C1QL1,C1QTNF3,CHAC1,CR1,CSRNP3,CUBN,CYP39A1,EMILIN2,EMX2,FAM111A,FAM234B,FAT4,FRRS1,HCRTR2,HNRNPM,ITGB3,KIFC1,KMT5A,LRP4,LRP5,MAPK4,MATR3,MEGF10,MMRN1,NUBP1,PGK1,PIF1,PLG,PLIN2,POU3F3,PRKCSH,PTGIR,RAB11A,RRM2,RSL24D1,SCARF1,SUSD2,SVEP1,TENM3,THSD4,TNFSF14,TPPP3,TRIM2,TRIM56,TULP4 54 (51) 41 CASP3,Cofilin,TJP1 AKT1,CDH2,Histone h2a,PCGF2,PDK1 RAC2 enzyme -0.000 3 -1.213 1.29E-04 1.17E-02 ACHE,Akt,Ap1,APP,AR,CDKN1B,CEBPA,COP1,CREB1,CTNNB1,CYP19A1,EIF4E,ELAVL1,ERK1/2,ESR1,ESR2,ETS2,FADD,FOS,GLI1,HIF1A,HNF1A,HNF4A,IFNAR1,IGF1,IL10,IRF3,Jnk,MAP3K3,MAPK1,MAPK14,MAPT,MITF,MYB,MYC,MYOD1,NGEF,NRAS,P38 MAPK,PAK1,PDPK1,PGR,Plc beta,PLCG2,PLD1,PLD2,PPARA,PPARGC1A,PPP3R1,RAC2,RAF1,RB1,RICTOR,RXRA,S100A9,SIRT1,STAT4,STK11,TGFB1,TNF,TWIST1,Vegf ABCA5,AIMP2,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ASPG,ATL2,BCHE,BIRC2,BIRC3,C1QTNF3,CACHD1,CALM1 (includes others),CALML3,CASP2,CD209,CEBPD,CGAS,CLEC10A,CLPB,CR1,Cyp2d22,EMILIN2,ETNK1,FASN,FCGBP,FGL1,FLNC,FUT6,GSTM3,HCRTR2,ITGB3,L1CAM,Lgals6,LRP6,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PIF1,PKD1L2,PLG,PTPRK,RAB11A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SUSD2,SVEP1,SYT12,THSD4,TMPRSS6,TNFSF14,TNR,TPPP3,TRIM56,TRPM2,VPS25 68 (62) 55 8-bromo-cAMP,ENG,HIPK2,ITGA4,VAV1,WNT5A AKT1,cyclophosphamide CDH5,PLD1 NTRK1 kinase 2 -1.372 1.32E-04 6.90E-03 ACHE,Akt,AKT1,Creb,CREB1,ERK,ERK1/2,HRAS,JUN,MAPK1,Mek,NFkB (complex),NTRK1,P38 MAPK,p85 (pik3r),Pkc(s),PPARG,RHOB,SRC ACAA1,ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,BIRC2,CALCRL,CASP2,CEBPD,DGAT1,DPY19L3,FASN,FLNC,HNRNPM,IFI44,ITGB3,KRT8,L1CAM,LITAF,MATR3,MGAT4C,PGK1,PLG,PLIN2,POLI,PTPRK,RRM2,SERINC2,SLC5A7,SOD3,TENM3,TNFSF14 34 (19) 18 8-bromo-cAMP,CNTF,ganglioside,GDF2,PRNP,RXRA anandamide,AZ-23,birabresib,ESR2,HIPK2,L-triiodothyronine,LOXO-195,resiniferatoxin ACHE,AKT1,NFkB (complex),p85 (pik3r),phosphatidylinositol 3,4-diphosphate,PLC gamma STRADB kinase 3 -0.944 1.34E-04 2.62E-02 AKT1,Ap1,APP,CCND1,CCND3,CDKN1A,Creb,CTNNB1,CYP19A1,EIF2AK3,EIF4E,ERK1/2,ESR1,estrogen receptor,ETV1,FOS,HIF1A,HNF4A,HSF1,INSR,IRF3,Jnk,JUN,JUNB,KAT5,MAPK10,MAPK12,MAPK8,MAPK9,MAPT,MKNK1,MYC,MYOD1,NFATC1,NFATC2,P38 MAPK,PAX2,RICTOR,RXRA,SIRT1,SPIB,STAT3,STAT4,STRADB,TP53 ABCA3,ACAA1,ADGRG6,ANGPTL3,ANK1,ANOS1,AOC1,ASPG,B4GALT1,BBX,BIRC3,CALCRL,CALM1 (includes others),CASP2,CD209,CELSR1,CSMD3,Cyp2d22,DGAT1,DPY19L3,DUT,EMX2,FASN,FCGBP,FLNC,FUT6,GNAO1,GSTM3,HCRTR2,HNRNPM,ITGB3,KIFC1,KRT8,Lgals6,LGMN,LRP6,MATR3,NLGN2,NUBP1,PLIN2,PNLIP,POLI,POU3F3,PPP1CA,RSL24D1,SLC16A4,SLC16A7,SOD3,SUSD2,THSD4,TMPRSS6,TPPP3,TRPM2,TSG101,WRN 55 (45) 42 indole-3-carbinol chemical drug 3 -0.258 1.35E-04 2.53E-02 AHR,APP,CASP3,CDK2,CDK6,CDKN1A,CDKN1B,CDKN2A,CTNNB1,CXCL8,Cyclin E,CYP19A1,CYP1A1,DICER1,doxorubicin,E2F3,EIF2AK3,ESR1,ESR2,FOS,GST,GSTK1,GSTO1,HIF1A,HNF4A,HRAS,IFN alpha/beta,IL1B,IL22,IL6,indole-3-carbinol,INSR,IRF3,Jnk,MAPT,MITF,MYB,NFkB (complex),NFKB1,NFKB2,nitric oxide,NOS3,NR1I2,PARP1,PPARGC1A,RB1,SIRT1,SMARCA4,SOX2,STAT5B ADGRG6,AKNA,ALDH7A1,ANGPT2,ANOS1,ASPG,B4GALT1,BIRC2,C1QL1,C1QTNF3,CACHD1,CALCRL,CALML3,CEBPD,CELSR1,CGAS,CHAC1,CLEC10A,CLPB,CR1,CYP39A1,EMILIN2,FAM111A,FCGBP,FGL1,FUT6,GLB1,GNAO1,H2BC21,HCRTR2,IFI44,ITGB3,KMT5A,LRP4,LRP5,MAPK4,MEGF10,NUBP1,PIF1,PNLIP,POU3F3,REG1A,RRM2,RRP12,SLC16A4,SLC5A7,SNAP25,SOD3,SUSD2,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNR,TPPP3,TRAF3IP2,TRIM36,TRPM2,TULP4 60 (50) 44 CASP3 NFkB (complex),TRAF1 PTPA phosphatase 0.000 2 1.265 1.35E-04 4.00E-04 AKT1,MDM2,PTPA BIRC3,CASP2,CEBPD,FASN,H2BC21,HNRNPM,MATR3,PLG,TSG101,WRN 10 (3) 2 AKT1,MDM2 MAP3K10 kinase 3 -1.386 1.37E-04 1.95E-02 APP,CDKN1B,CEBPA,CITED2,CREB1,CTNNB1,CYP19A1,EGFR,EIF2AK3,EIF4E,ERK,ESR1,ETS2,FADD,FOS,HIF1A,HNF1A,HNF4A,IFNAR1,IGF1,IRF3,Jnk,JUN,MAP2K4,MAP2K7,MAP3K,MAP3K10,MAPK1,MAPK10,MAPK14,MAPK8,MAPK9,MAPT,MITF,MYB,MYOD1,NCAM1,NDP,NEUROD1,NFATC2,NFkB (complex),NFKBIA,P38 MAPK,PGR,PPARA,PPARGC1A,RB1,RICTOR,RXRA,S100A9,SIRT1,SPP1,TCF3,TNF ADGRG6,ALDH7A1,ANGPT2,ANGPTL3,ANK1,ANOS1,ASPG,ATL2,B4GALT1,BBX,BCHE,BIRC2,BIRC3,CD209,CEBPD,CGAS,CLEC10A,CLPB,CYP39A1,DGAT1,EMILIN2,ETNK1,FGL1,FLNC,FUT6,GSTM3,H2BC21,HCRTR2,IFI44,ITGB3,Lgals6,LITAF,LRP6,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PGK1,PIF1,PKD1L2,PLG,PLIN2,PNLIP,POLI,POU3F3,PTPRK,RSL24D1,SERINC2,SLC16A4,SOD3,SUSD2,SVEP1,THSD4,TMPRSS6,TNR,TNXB,TPPP3,TRIM56,TRPM2,TULP4 63 (54) 49 anisomycin,caspase MAP3K11 L-triiodothyronine chemical - endogenous mammalian 3 0.367 1.42E-04 1.30E-02 ACHE,Akt,AKT1,AMPK,CDK2,CDKN2A,CFTR,CHRNA7,CREB1,CTNNB1,CYP19A1,DIO2,DIO3,doxorubicin,E2F3,EIF2AK3,ERK,ERK1/2,FADD,FGF2,FGFR1,HIPK2,HNF1A,HOXA10,IFNGR1,IL6,JAK1,JAK2,Jnk,L-triiodothyronine,MAP3K7,MITF,MLXIPL,NFkB (complex),NFKBIA,NOS3,NRAS,p70 S6k,PI3K (complex),Pka,PLA2G2A,PRKCE,RB1,SMAD3,SMARCA4,SNCA,SOX2,SPARC,SRC (family),STAT3,TCF7L2,TGFB1,THRA,THRB,TNF,TNFSF11 ACAA1,ADAMTS16,ADGRG6,AIMP2,AKNA,ALDH7A1,ANGPTL3,AOC1,ARL6IP4,ASPG,B4GALT1,BCHE,C1QL1,CALCRL,CALML3,CD209,CELSR1,CHAC1,CHRNA10,CHRNB3,CLEC10A,CUBN,DGAT1,EMX2,ETNK1,FAM111A,FASN,FGL1,FRRS1,H2BC21,HNRNPM,IFI44,ITGB3,KIFC1,KMT5A,KRT8,L1CAM,LRP4,LRP5,MAPK4,MATR3,MEGF11,MGAT4C,NCAN,PGK1,PIF1,PKD1L2,PLIN2,PNLIP,PTPRK,SERINC2,SLC16A4,SLC5A7,SNAP25,SSPOP,SUSD2,SYCE2,SYT12,TKFC,TNFSF14,TNR,TRIM2,TRIM3,TRIM36,TRIM56,VPS25,XPO7 67 (56) 45 SLC5A5 carbon tetrachloride,iopanoic acid,LG100268,tunicamycin ACHE,ACSL1,AKT1,CCNE1,DAB2IP,DBP,ENG,EPAS1,ESR2,fatty acid,FZD8,INHA,ITPR1,MAP3K7,Na+,K+ -ATPase,NR5A2,p85 (pik3r),PGR,POR,POU5F1,PTAFR,RASGRP1,RBP1,RGS16,RPS6KA4,RPS6KB1,SEMA7A,SFRP2,SLC2A1 ADAM10,BTG2,CASP3,CDKN2A,CYP27B1,DVL1,EHHADH,FASLG,Frizzled,IGFBP6,INS,miR-133a-3p (and other miRNAs w/seed UUGGUCC),NFkB (complex),NR0B1,NTRK1,PTTG1,RELN,SCD,UBA1,urea ICOS transmembrane receptor 3 Activated 2.177 1.43E-04 9.20E-03 26s Proteasome,AHR,APP,CD40,CD40LG,CTNNB1,CXCL8,EGLN,ELAVL1,ERK,FADD,GNE,Hdac,HIF1A,HNF4A,HRAS,ICOS,IFNG,IL10,IL1B,IL6,IRF3,ITGB1,Jnk,NFkB (complex),NFKB2,NRAS,PDPK1,PI3K (complex),Pkc(s),PLC gamma,PRKCE,PSEN1,RB1,REL,RICTOR,S100A8,S100A9,SIRT1,SLC18A3,STAT6,TNF,TWIST1 ADGRG6,ADRM1,AGA,ALDH7A1,ANOS1,B4GALT1,BBX,BCHE,BIRC2,BIRC3,C1QTNF3,CACHD1,CD209,CGAS,CHAC1,CHRNB3,CLEC10A,CR1,EMILIN2,ETNK1,FASN,FAT4,FCGBP,FGL1,FUT6,H2AC21,HCRTR2,IFI44,ITGB3,KRT8,LRP4,MAPK4,PLG,POU3F3,PTPRG,RAB11A,RRP12,RSL24D1,SLC16A4,SLC5A7,SOD3,SUSD2,SYT12,TENM3,THSD4,TMPRSS6,TNR,TNXB,TPPP3,TRAF3IP2,TRIM56,TULP4,VPS25,XPO7 54 (43) 41 ADAM10,EPAS1,IL27 SUPT20H,tacrolimus IgG,PLC gamma CASR G-protein coupled receptor 2 -1.177 1.44E-04 4.00E-03 Akt,Ap1,CASR,CTNNB1,ERK,ERK1/2,Jnk,JUN,MAPK1,MAPK3,MAPK8,SRC ACAA1,ADGRG6,AIMP2,ANGPT2,AOC1,B4GALT1,CALM1 (includes others),CD209,CEBPD,CLEC10A,DGAT1,EMX2,FASN,FLNC,IFI44,KIFC1,L1CAM,PGK1,PLG,PLIN2,POLI,PPP1CA,PTPRK,RRM2,SUSD2,TNFSF14 26 (12) 12 cocaine,denatonium benzoate,tunicamycin BMP7,CASP3,CCND2,CXCL10,CYP2B6,KIF22,PPP1CA,PRKD2,PTTG1,RAPGEF1,S100A9 CISH,SOCS3 lactacystin chemical - protease inhibitor 3 0.728 1.46E-04 2.74E-02 20s proteasome,26s Proteasome,Akt,AKT1,Alpha catenin,APP,ATF4,beta-estradiol,CASP3,CASP8,CCND1,CDK2,CDKN2A,CFTR,CTNNB1,Cyclin E,DICER1,doxorubicin,DRD2,E2F3,EIF2AK3,ERK1/2,ESR1,ETS2,FADD,FMR1,FOS,GJA1,HIF1A,HRAS,IL10,IL1B,lactacystin,MET,MITF,MYCN,MYOD1,NFATC2,NGEF,nitric oxide,NOS1,NOS3,p70 S6k,PDPK1,PRKCE,PSMB1,RB1,RGS4,RICTOR,RPS6KB1,SMARCA4,SPARC,STAT1,STK11,TCF7L2,tetradecanoylphorbol acetate,TNFSF11,TSC1,TWIST1,VDR ABCA3,ACAA1,ADGRG6,ADRM1,AGA,AIMP2,AKNA,ANGPT2,AOC1,BBX,C1QTNF3,CALCRL,CASP2,CELSR1,CHAC1,CHRNB3,CR1,CUBN,EMX2,ETNK1,FAM111A,FASN,FAT4,FRRS1,H2BC21,HCRTR2,HNRNPM,IFI44,ITGB3,KIFC1,KMT5A,L1CAM,Lgals6,LRP5,MAPK4,MATR3,MEGF11,MEGF6,MKX,NUBP1,PIF1,PLG,PLIN2,PNLIP,PTGIR,PTPRG,PTPRK,RAB11A,REG1A,RRM2,RSL24D1,SCARF1,SLC16A4,SLC16A7,SNAP25,SOD3,SSPOP,SUSD2,SYCE2,TENM3,THSD4,TMPRSS6,TNFSF14,TPPP3,TRAF3IP2,TRIM2,TRIM36,TRPM2 68 (60) 51 AKT1,ATF3,CASP3,caspase,CAV3,CCND2,FANCC,HMOX1,Hsp90,HSPB1,IRS1,MDM2,PAK2,PEA15,PPP5C,RPS6KB1,SIAH1,SLC3A2 BCAR1,FASLG,prostaglandin E2,RGS4,TACSTD2 CHI3L1 enzyme 3 Inhibited -2.216 1.46E-04 1.59E-02 26s Proteasome,ACHE,Akt,Alpha catenin,AMPK,Ap1,APP,AR,CDKN1B,CEBPA,CHI3L1,COP1,CREB1,CTNNB1,CXCL8,CYP19A1,EGFR,EIF2AK3,EIF4E,ELAVL1,ERK1/2,ESR1,ESR2,ETS2,FOS,HNF4A,HRAS,IGF1,IL10,INSR,IRF3,ITGB1,MAPT,MITF,MLXIPL,MMP9,MYB,MYC,NEDD9,NFATC2,NFkB (complex),NGEF,NR1I3,P38 MAPK,PPARA,PPARGC1A,PRKAA,PTK2,RAF1,RB1,S100A9,SIRT1,TCF7L2,TGFB1,TNF,TSC1,TWIST1,VDR,Vegf ACAA1,ADRM1,AGA,AIMP2,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,ASPG,ATL2,BBX,BCHE,BIRC2,BIRC3,C1QTNF3,CACHD1,CALM1 (includes others),CALML3,CEBPD,CLPB,CR1,CUBN,Cyp2d22,CYP39A1,EMILIN2,EMX2,FASN,FAT4,FCGBP,FUT6,HCRTR2,ITGB3,KIFC1,KMT5A,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PGK1,PIF1,PLG,PLIN2,PNLIP,RRM2,RRP12,SCARF1,SERINC2,SLC16A7,SLC5A7,SUSD2,SVEP1,SYT12,TENM3,THSD4,TKFC,TNFSF14,TNR,TNXB,TPPP3,TRIM56,TRPM2,TULP4 66 (59) 57 mir-182 Ca2+ DAB2IP other 3 0.516 1.47E-04 1.36E-02 AHR,Akt,AKT1,APP,AR,CDKN1B,CEBPA,CREB1,CTNNB1,CXCL8,DAB2IP,DLX5,EPAS1,ERK,ETS2,FADD,FMR1,HIF1A,HNF1A,IL10,IL1B,IL6,Jnk,MAP3K5,Mapk,MITF,NFATC2,NFkB (complex),NGEF,NR1I2,NRAS,PDPK1,PI3K (complex),PLK1,PPARGC1A,REL,RPS6KA1,RPS6KB1,SNCA,SOX2,SPARC,STK11,TCF,TCF4,TCF7L2,TNF,TNFSF11,VDR ACAA1,ADGRG6,AGA,AIMP2,ALDH7A1,B4GALT1,BBX,BIRC2,C1QL1,CD209,CEBPD,CHAC1,CLEC10A,CLPB,CR1,CUBN,Cyp2d22,CYP39A1,EMX2,ETNK1,FAM111A,FGL1,FRRS1,HNRNPM,HSD3B2,ITGB3,KIFC1,KMT5A,LRP4,MATR3,MEGF11,MGAT4C,MKX,MMRN1,NANOS1,PGK1,PIF1,PKD1L2,PLIN2,POU3F3,RAB11A,RRM2,SCARF1,SERINC2,SLC16A4,SOD3,SUSD2,SVEP1,SYCE2,SYT12,THSD4,TMPRSS6,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM2,TRIM3,TRIM56,VPS25 60 (48) 40 L-triiodothyronine MIR17HG AKT1,EPAS1,KIT,NFkB (complex),RPS6KB1 prostaglandin A2 chemical - endogenous non-mammalian 3 Inhibited -2.433 1.48E-04 1.28E-02 ABCB4,AHR,AR,CASP3,CDK4,CDKN1B,CDKN2A,Creb,CREB1,CXCL8,Cyclin E,DICER1,EIF4E,ERK,ESR1,FADD,FOS,GLI1,HRAS,IGF1,IL1B,IL2,IL6,Jnk,KRT8,MITF,MYB,MYOD1,NFATC2,NFkB (complex),NFKB2,P38 MAPK,PDPK1,PPARA,PPARD,PPARG,PPARGC1A,progesterone,prostaglandin A2,RAC1,RB1,REL,RICTOR,S100A9,SIRT1,SMARCA4,STAT4,TCF7L2,TNF,TWIST1 ACAA1,ADGRG6,AGA,ALDH7A1,ANGPT2,ANGPTL3,ANK1,ATL2,B4GALT1,BBX,BCHE,BIRC2,C1QTNF3,CALCRL,CD209,CELSR1,CGAS,CLEC10A,CLPB,CR1,Cyp2d22,CYP39A1,DGAT1,DPY19L3,EMILIN2,ETNK1,FAM111A,FASN,FAT4,FCGBP,FGL1,GSTM3,H2BC21,HCRTR2,ITGB3,KMT5A,Lgals6,LRP5,MAPK4,MEGF10,MGAT4C,NLGN2,NUBP1,PIF1,PLG,PLIN2,PTGIR,RAB11A,REG1A,RRM2,RSL24D1,SERINC2,SOD3,SVEP1,TENM3,TNR,TRAF3IP2,TRIM36,TRIM56,TRPM2,TULP4 61 (50) 45 CASP3,HMOX1,PPARA,PPARD NFkB (complex) MAP3K8 kinase 3 -1.195 1.49E-04 2.28E-02 ACHE,Akt,Ap1,APP,BHLHE40,CASP3,CDKN1B,CDKN2A,CEBPA,CHUK,CXCL8,DICER1,ELAVL1,ELK1,EPAS1,ERK,ERK1/2,ESR2,ETS2,FADD,FOS,HIF1A,HNF1A,IFNAR1,IGF1,IKBKB,IL10,IL1B,IL2,Jnk,JUN,MAP2K1,MAP2K5,MAP2K6,Map3k7,MAP3K8,Mapk,MAPK1,MAPK10,MAPK12,MAPK14,MAPK3,MAPK7,MAPK8,MAPK9,Mek,MITF,MYB,MYOD1,Nfat (family),NFATC2,NFkB (complex),NFKB1,NFKBIA,NGEF,P38 MAPK,PDPK1,PIN1,PP2A,PPIF,PPP3R1,PRKCE,PRMT1,RB1,REL,RICTOR,Rsk,S100A9,STING1,STK11,TCF7L2,TNF,TP53,VDR ABCA5,ADGRG6,AGA,AIMP2,ALDH7A1,ANGPT2,AOC1,ATL2,B4GALT1,BBX,BCHE,CACHD1,CALCRL,CALM1 (includes others),CASP2,CD209,CEBPD,CELSR1,CGAS,CHRNB3,CLEC10A,CLPB,CR1,CSMD3,CUBN,DGAT1,DUT,ETNK1,FAM111A,FLNC,GLB1,GNAO1,IFI44,ITGB3,KIFC1,KMT5A,L1CAM,Lgals6,LITAF,LRP5,LRP6,MAPK4,MEGF10,MKX,MMRN1,NCAN,NUBP1,PIF1,PKD1L2,PLG,PLIN2,POLI,PPP1CA,PTGIR,RAB11A,RRM2,RRP12,RSL24D1,SCARF1,SLC16A4,SLC5A7,THSD4,TMPRSS6,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM56,TSG101,TULP4 70 (74) 62 AKT1,Collagen type II,phorbol 12,13-dibutyrate piceatannol CASP3,Map3k7,MAPK7,PGR,SOCS3 IFNB1,RGS3 PLAC8 other -0.000 2 -1.265 1.51E-04 5.00E-04 AKT1,MDM2,PLAC8 BIRC3,CASP2,CEBPD,FASN,H2BC21,HNRNPM,MATR3,PLG,TSG101,WRN 10 (3) 2 BHLHE40 quercetin AKT1,MDM2 Map3k7 kinase 3 -0.868 1.51E-04 1.67E-02 26s Proteasome,ACHE,Akt,Ap1,APP,CASP3,CEBPA,CHUK,CREB1,CXCL8,CYP19A1,DICER1,EIF2AK3,EIF4E,ERK,ERK1/2,ESR2,ETS2,FADD,HIPK2,IGF1,IL10,IL1B,IL2,IL6,IRF3,JINK1/2,Jnk,JUN,MAP3K3,Map3k7,Mapk,MAPK8,MAPT,MITF,MYB,NFATC2,NFkB (complex),NFKBIA,NGEF,NLK,P38 MAPK,PDPK1,PPARA,PPP3R1,PRKAA,PRKAA1,PRKAA2,RB1,RICTOR,S100A9,SMAD2,SMAD3,SMARCA4,STK11,TCF7L2,TNF,TWIST1,VDR ABCA5,ADGRG6,ADRM1,AIMP2,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,ASPG,ATL2,B4GALT1,BBX,BCHE,CALM1 (includes others),CEBPD,CGAS,CLEC10A,CR1,CUBN,DUT,ETNK1,FASN,FAT4,FGL1,H2BC21,HSD3B2,ITGB3,KMT5A,KRT8,L1CAM,LITAF,LRP5,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NCAN,NLGN2,PGK1,PIF1,PLG,PNLIP,POLI,PTGIR,PTPRK,RAB11A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC5A7,SOD3,THSD4,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM36,TRIM56,TULP4,XPO7 65 (59) 52 camptothecin,MAP3K8,quercetin,sorbitol Ppp1cc,PPP3CA,PPP3R1,TNFAIP8L2,USP18,USP19 BHLHE40,CCL3L3,CXCL10,HAS2,IFNB1,JINK1/2,NFkB (complex),PRKAA1,SPHK1 CASP3,S100A9,SCD,Srebp nifedipine chemical drug 2 Activated 2.043 1.53E-04 5.00E-03 Akt,AKT1,Creb,ERK,ERK1/2,IGF1R,Jnk,MAPK1,Nfat (family),NFKB1,nifedipine,NOS3,NR1I2,P38 MAPK,Pkc(s),PPARG,SMAD3 ACAA1,ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,CEBPD,CLEC10A,CYP39A1,DGAT1,DPY19L3,FLNC,GNAO1,GSTM3,HNRNPM,HSD3B2,IFI44,ITGB3,KRT8,L1CAM,MATR3,PLG,PLIN2,PTPRK,RRM2,SOD3,TNFSF14 29 (17) 16 CYP2B6,FGF7,IRS1 AKT1,ATP2B2,Ca2+,CASP3,iron iron chemical - endogenous mammalian 3 -0.674 1.54E-04 1.47E-02 26s Proteasome,ACHE,Akt,AMPK,APP,CASP3,CDKN1B,CEBPA,CREB1,DICER1,DLX5,docosahexaenoic acid,EGFR,EGLN,EIF2AK3,ELAVL1,ERK,ERK1/2,ESR1,ESR2,ETS2,FADD,HIF1A,HIPK2,HNF4A,HRAS,IKK (complex),IL10,IL27,IRF3,iron,ITGB1,Jnk,MAP3K7,MAPT,MITF,mitomycin C,MLXIPL,NFKBIA,NGEF,Nos,NR1I3,PPARA,PPARD,PPARGC1A,RICTOR,SIRT1,STK11,TNF ADGRG6,ADRM1,AIMP2,ANGPT2,ANGPTL3,ANOS1,AOC1,ASPG,BBX,BIRC2,CACHD1,CD209,CEBPD,CLEC10A,CLPB,CR1,CYP39A1,EMILIN2,ETNK1,FASN,FUT6,HCRTR2,IFI44,ITGB3,L1CAM,LRP5,MEGF10,MGAT4C,MKX,MMRN1,NCAN,PGK1,PIF1,PNLIP,POU3F3,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC5A7,SVEP1,TENM3,THSD4,TKFC,TMPRSS6,TNFSF14,TNR,TNXB,TPPP3,TRIM56,TRPM2,TULP4,XPO7 55 (49) 46 1-methyl-4-phenylpyridinium,6-hydroxydopamine,GAST,l-asparaginase,peroxynitrite deferoxamine,EIF2AK1,NFkB (complex),nifedipine,protocatechuic acid,SOD1 CASP3,caspase,CCND2,MAP3K7,Mt CCNE1,PPP1R15A NLRX1 other 3 -0.832 1.54E-04 1.69E-02 AHR,APP,CDKN1B,CDKN2A,CEBPA,CHUK,Creb,CSF2,CXCL8,EIF4E,ERK,ERK1/2,estrogen receptor,FADD,FOS,FOXA2,GLI1,HIF1A,HNF4A,IKBKB,IKK (complex),IL1B,IL6,IRF3,Jnk,KRT8,MAPT,MAVS,MYC,NFkB (complex),NFKB1,NFKB2,NFKBIA,NLRX1,NR1I2,REL,RICTOR,RXRA,TNF,TWIST1 ABCA3,ADGRG6,AGA,ALDH7A1,ANGPTL3,ANOS1,AOC1,ASPG,B4GALT1,BIRC2,BIRC3,C1QTNF3,CD209,CEBPD,CGAS,CLEC10A,CLPB,CR1,CYP39A1,DPY19L3,EMILIN2,ETNK1,FAM111A,FAT4,FCGBP,FGL1,FLNC,FUT6,GNAO1,GSTM3,ITGB3,KRT8,LGMN,MMRN1,NCAN,NLGN2,NUBP1,PLG,POU3F3,REG1A,RSL24D1,SLC16A4,SLC16A7,SOD3,SYT12,THSD4,TMPRSS6,TNR,TPPP3,TRAF3IP2,TRIM56,WRN 52 (40) 39 quercetin ammonium FASLG,IFNB1,NFkB (complex),SLC2A1 SH3BP2 other -0.000 3 -1.638 1.55E-04 1.56E-02 Akt,AKT1,Alpha catenin,Ap1,APP,AR,CDKN1B,CREB1,CTNNB1,CYP19A1,EIF4E,ERK,ERK1/2,ESR1,ETS2,FADD,FOS,HIF1A,HIPK2,HRAS,IKZF1,IL10,Jnk,KIT,KRT8,LAT,LYN,MAP2K1/2,MAPT,MITF,MYC,MYCN,NFATC2,NGEF,NR1I3,NRAS,PGR,PLC gamma,PPARA,PPARGC1A,PRKCE,RAF1,REL,RICTOR,SH3BP2,SIRT1,SNCA,SOX2,SPARC,SRC (family),STAT1,STK11,SYK,SYK/ZAP,TNF,TNFSF11,TWIST1,Vegf ADGRG6,AGA,AIMP2,ANGPT2,AOC1,ASPG,BBX,BIRC2,C1QL1,C1QTNF3,CALM1 (includes others),CASP2,CD209,CEBPD,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,Cyp2d22,CYP39A1,EMILIN2,ETNK1,FASN,FAT4,FCGBP,FRRS1,GSTM3,HCRTR2,HNRNPM,ITGB3,L1CAM,LRP4,MATR3,MEGF11,MGAT4C,MKX,NLGN2,NUBP1,PIF1,PLG,PTPRK,REG1A,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SUSD2,SVEP1,TENM3,THSD4,TMPRSS6,TNFSF14,TPPP3,TRIM2,TRIM3,TRIM56,TRPM2,TULP4,VPS25,XPO7 63 (58) 50 CDKN2A AKT1,PLC gamma FAF1 other -0.000 3 -0.927 1.56E-04 2.01E-02 26s Proteasome,AHR,AKT1,APP,CD24,CD40,CDKN2A,CEBPA,Creb,CTNNB1,CXCL8,EIF4E,ESR1,estrogen receptor,FADD,FAF1,FOS,HMOX1,HNF4A,Hsp70,IKBKB,IL1B,IL6,IRF3,Jnk,JUN,KRT8,MAPT,MTOR,NFkB (complex),NR1I2,PDPK1,REL,RELA,RICTOR,RXRA,SIRT1,TCF7L2,TNF,TWIST1,VDR ACAA1,ADRM1,AGA,ALDH7A1,ANGPTL3,ANOS1,ASPG,B4GALT1,BIRC2,CD209,CEBPD,CLEC10A,CR1,CUBN,CYP39A1,DPY19L3,EMILIN2,EMX2,ETNK1,FAM111A,FASN,FAT4,FCGBP,FGL1,FLNC,FUT6,GSTM3,HCRTR2,HNRNPM,ITGB3,KIFC1,KMT5A,KRT8,L1CAM,MATR3,MMRN1,NLGN2,NUBP1,PGK1,PLG,PLIN2,POLI,POU3F3,RAB11A,REG1A,RRP12,RSL24D1,SOD3,SUSD2,SYT12,THSD4,TNR,TPPP3,TRAF3IP2,TRIM2,TRIM56,TRPM2 57 (41) 39 HOXA10 NFkB (complex) Ahr-aryl hydrocarbon-Arnt complex 3 0.324 1.58E-04 1.19E-02 AHR,Ahr-aryl hydrocarbon-Arnt,Akt,ARNT,aryl hydrocarbon,EGFR,Esr1-Estrogen-Sp1,ESR2,estrogen,estrogen receptor,Estrogen-ER,HIF1A,IL22,Jnk,MAPK8,MITF,NFKBIA,P38 MAPK,RAF1,RB1,SMAD4,SP1,tanespimycin AIMP2,ALDH7A1,ANK1,B4GALT1,CALCRL,CALM1 (includes others),CALML3,CD209,CELSR1,CLEC10A,DGAT1,DUT,EMILIN2,FLNC,GLB1,H2BC21,HNRNPM,ITGB3,KIFC1,LITAF,MAPK4,MEGF10,NCAN,PGK1,PIF1,PLG,PTPRK,RAB11A,RRP12,SLC16A4,SLC16A7,SLC5A7,SNAP25,SOD3,SYT12,TMPRSS6,TNFSF14,TNXB 38 (23) 19 EP300,NCOA3 FASLG gallamine triethiodide chemical drug 3 1.800 1.59E-04 3.50E-03 ACHE,Akt,AKT1,CHRM2,EGFR,ERK,ERK1/2,gallamine triethiodide,MAPK1,MAPK14,MAPT,PRKCE,RAS,RGS4 ADGRG6,AIMP2,ANGPT2,AOC1,ASPG,B4GALT1,BIRC2,BIRC3,CEBPD,CHRNB3,FLNC,HNRNPM,IFI44,ITGB3,L1CAM,LRP6,MATR3,MEGF6,PLG,PTPRK,RRM2,SLC5A7,SSPOP,TNFSF14,TNXB 25 (14) 12 ACHE PD173074 chemical reagent 2 Activated 2.132 1.59E-04 2.40E-03 Akt,AKT1,ERK,ERK1/2,FGFR2,FGFR4,PD173074,RB1 ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CALCRL,CEBPD,CELSR1,CUBN,DGAT1,FASN,H2BC21,HNRNPM,ITGB3,L1CAM,MAPK4,MATR3,PLG,RRM2,TENM3,TNFSF14 22 (8) 7 CCR7,CDH5,LHB,MFAP5,PGF,PPARD,VTCN1 AKT1,CCND2,FGFR3,FGFR4,RPS6KB1 glabridin chemical - endogenous non-mammalian 3 -1.807 1.62E-04 2.31E-02 AHR,AKT1,AMPK,Ap1,APP,CDKN1B,CEBPA,Creb,CREB1,CSF2,CXCL8,EGLN,EIF2AK3,EIF4E,ELAVL1,ERBB2,ERK,ERK1/2,FOS,glabridin,GNE,Hdac,HIF1A,HRAS,IL1B,IL2,IL6,INSR,IRF3,ITGB1,MLXIPL,MYC,NFkB (complex),NFKB2,NFKBIA,NRAS,Pkc(s),PPARA,PPARGC1A,PRKCE,PSEN1,RAF1,RB1,REL,S100A8,S100A9,SIRT1,SLC18A3,Sod,STAT4 ADGRG6,AGA,ALDH7A1,ANGPTL3,ANOS1,AOC1,B4GALT1,BBX,BCHE,BIRC2,BIRC3,C1QTNF3,CACHD1,CALM1 (includes others),CEBPD,CGAS,CHAC1,CHRNB3,CLPB,CR1,Cyp2d22,DPY19L3,DUT,EMILIN2,FASN,FCGBP,FGL1,HCRTR2,HNRNPM,KRT8,LGMN,LRP4,MAPK4,MATR3,MGAT4C,MMRN1,NCAN,NLGN2,NUBP1,PNLIP,POU3F3,PTGIR,REG1A,SERINC2,SLC16A4,SLC16A7,SLC5A7,SOD3,SVEP1,SYT12,TENM3,THSD4,TKFC,TMPRSS6,TNXB,TPPP3,TRAF3IP2,TULP4,VPS25,WRN 60 (50) 48 NFkB (complex) RPS6KA4 kinase -0.000 3 -0.405 1.65E-04 2.24E-02 AHR,APP,ATF4,CEBPA,COP1,Creb,CREB1,CSF2,CXCL8,EIF4E,ERK,ERK1/2,estrogen receptor,FADD,FOS,HISTONE,Histone h3,HNF4A,IL1B,IL6,IRF3,Jnk,JUN,KMT2A,KRT8,MAPT,MYC,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,PPARGC1A,RB1,REL,RICTOR,RPS6KA4,TGFB1,TNF,TWIST1 ABCA3,ADGRG6,AGA,ALDH7A1,ANOS1,AOC1,ASPG,B4GALT1,BIRC2,C1QTNF3,CALML3,CD209,CEBPD,CHAC1,CLEC10A,CR1,CYP39A1,DPY19L3,ETNK1,FASN,FAT4,FCGBP,FGL1,FLNC,FUT6,GNAO1,GSTM3,HSD3B2,KRT8,LGMN,LITAF,MAPK4,MGAT4C,MKX,MMRN1,NCAN,NLGN2,NUBP1,PLG,POLI,POU3F3,REG1A,RRM2,RSL24D1,SERINC2,SLC16A7,SOD3,SVEP1,SYT12,THSD4,TNR,TPPP3,TRAF3IP2,TRIM56,WRN 55 (40) 38 L-triiodothyronine NFkB (complex) IFNB1 WNT3A cytokine 3 -0.970 1.67E-04 1.67E-02 ACHE,Akt,ALK,AR,CDKN1B,CTNNB1,EIF4E,ERK,ERK1/2,ESR2,ETS2,FADD,FGFR2,FOS,FOXM1,GSK3B,HNF1A,HRAS,IGF1,IL10,INSR,IRF3,Jnk,LEF1,LGALS3,LRP5,MAP3K3,mir-21,NGEF,NR1I3,NRAS,PI3K (complex),PIK3CA,PLD1,PPARGC1A,PPP3R1,PRKCI,PTK,PTPRJ,REL,RICTOR,ROCK,RUNX3,SNCA,SOX2,SP1,SRC,STAT3,STAT5B,STING1,TCF,TCF/LEF,TCF4,Tcf7,TCF7L2,TERT,TNF,TWIST1,WBP2,Wnt,WNT3A,WNT5A,WWOX ABCA5,ACAA1,ADGRG6,ADRM1,AGA,AIMP2,ANGPT2,ANOS1,AOC1,ATL2,BBX,BCHE,C1QL1,CD209,CEBPD,CGAS,CHAC1,CLEC10A,CLPB,CR1,CSRNP3,Cyp2d22,CYP39A1,EMILIN2,EMX2,ETNK1,FAM111A,FAM234B,FAT4,FCGBP,FGL1,FUT6,GLB1,GNAO1,HSD3B2,IFI44,ITGB3,KIFC1,KMT5A,LRP4,LRP6,MEGF10,MEGF11,MKX,NANOS1,NLGN2,NUBP1,PKD1L2,PLG,PLIN2,PRKCSH,RRM2,RRP12,RSL24D1,SCARF1,SLC5A7,SNAP25,SOD3,SUSD2,SVEP1,TENM3,TNFSF14,TNXB,TRIM2,TRIM3,TRIM56,TULP4,VPS25 68 (63) 52 BMP7,FSTL1,N-acetylmuramyl-L-alanyl-D-isoglutamine infliximab,SALL4 ACADS,ADAM10,caspase,CCN5,CCND2,CXCL10,Dishevelled,DVL1,EPAS1,FOXQ1,Frizzled,HAS2,Irgm1,IRS1,KIT,LRP5,LRP6,MMD,NR5A2,PIK3CA,PLD1,POU5F1,PROCR,SDC4,SFRP2,TERT,WNT5A ANGPT1,CCL3L3,CDH2,ENG,FZD4,PDGFRA,PMP22 wogonin chemical - endogenous non-mammalian 3 -1.313 1.67E-04 7.10E-03 2-amino-1-methyl-6-phenylimidazo-4-5-b-pyridine,26s Proteasome,ACHE,Akt,AMPK,CASP3,CAV1,CD40LG,clopidogrel,CNTF,CXCL8,CYP1A2,CYP2C19,DICER1,DLX5,EIF2AK3,EIF4E,ERK,ESR2,ETS2,HIF1A,HRAS,IFNG,IGF1,IL10,IL17F,IL1B,IL2,IL4,IL6,ITGB1,MAPK1,MAPK14,MITF,MLXIPL,NFkB (complex),NFKB2,NGEF,NR1I2,NRAS,P38 MAPK,PDPK1,PI3K (complex),Pro-inflammatory Cytokine,REL,S100A9,SIRT1,SREBF2,TGFB1,TNF,TNFSF11,wogonin ADGRG6,ADRM1,AGA,AIMP2,ALDH7A1,ANK1,ATL2,B4GALT1,BCHE,BIRC2,BIRC3,C1QTNF3,CACHD1,CALML3,CGAS,CHAC1,CR1,CYP39A1,FASN,FGL1,FLNC,FRRS1,GSTM3,H2AC21,HCRTR2,IFI44,LRP5,LRP6,MFSD1,MKX,NANOS1,NLGN2,PGK1,PIF1,PLG,PNLIP,POU3F3,PTGIR,PTPRG,PTPRK,RAB11A,REG1A,RRM2,RRP12,SCARF1,SLC16A4,SLC5A7,SOD3,TENM3,THSD4,TKFC,TMPRSS6,TNFSF14,TNR,TRAF3IP2,TRIM56,VPS25,XPO7 58 (52) 48 Ca2+,CASP3 NFkB (complex) Ppp1cc phosphatase 3 0.492 1.70E-04 2.82E-02 Ap1,APP,Calcineurin protein(s),CCND3,CDKN1B,COP1,Creb,CREB1,CTNNB1,CYP19A1,EGFR,EIF4E,ERK1/2,ESR1,ETS2,FADD,FOS,FOXO1,HIF1A,IGF1,IL10,IRF3,ITGB1,Jnk,JUN,KAT5,KRT8,LEP,Map3k7,MAPT,MDM2,MITF,MYB,MYOD1,NFATC2,NFkB (complex),NFKB2,NFKBIA,NR1I3,P38 MAPK,PGR,PPARA,PPARGC1A,Ppp1cc,PRKCH,RB1,REL,RICTOR,RXRA,S100A9,STAT1,STK11,TNF,TP53,TP73,TWIST1 AGA,ALDH7A1,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ASPG,ATL2,BBX,BCHE,C1QTNF3,CALCRL,CALM1 (includes others),CASP2,CD209,CEBPD,CELSR1,CLEC10A,CLPB,CR1,CSMD3,CYP39A1,DPY19L3,EMILIN2,ETNK1,FASN,FAT4,FCGBP,GSTM3,H2BC21,ITGB3,KIFC1,KRT8,Lgals6,LITAF,MAPK4,MEGF10,MGAT4C,MKX,NCAN,NLGN2,NUBP1,PIF1,PLG,POLI,POU3F3,PPP1CA,REG1A,RRM2,RSL24D1,SERINC2,SLC16A4,SOD3,SUSD2,SVEP1,SYT12,THSD4,TMPRSS6,TNR,TNXB,TPPP3,TRIM56,TRPM2,TSG101,TULP4 66 (56) 54 PPP1R9A,PPP1R9B Map3k7 huperzine A chemical drug 3 0.156 1.70E-04 1.50E-02 2-amino-1-methyl-6-phenylimidazo-4-5-b-pyridine,ACHE,ADAM10,ADAM17,aflatoxin B1,Akt,AKT1,Ap1,APP,AR,benzo(a)pyrene,CYP1A2,EGFR,ERBB2,ERBB3,ERK,ERK1/2,huperzine A,IGF1R,MAPK1,MAPK3,MAPT,MDM2,NFKBIA,Notch,NOTCH1,P38 MAPK,PRKCE,Ras homolog,STAT3 ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,ASPG,B4GALT1,CACHD1,CALM1 (includes others),CASP2,CD209,CHRNB3,CLEC10A,Cyp2d22,DPY19L3,FLNC,GNAO1,GSTM3,H2BC21,HNRNPM,HSD3B2,IFI44,ITGB3,KIFC1,KRT8,L1CAM,LITAF,LRP6,MATR3,NCAN,PGK1,POLI,POU3F3,RAB11A,SLC5A7,THSD4,TNFSF14,TNXB,TPPP3,TSG101,WRN 41 (30) 27 ADAM10 ACHE SOCS3 phosphatase 3 0.367 1.71E-04 1.69E-02 26s Proteasome,Akt,AKT1,APP,CDKN1B,CFTR,CHRNA7,Creb,EPO,ERK,ERK1/2,ETS2,FADD,Focal adhesion kinase,GLI1,HIF1A,HIPK2,HOXA10,HRAS,IFNGR1,Ige,IGF1,IL10,IL10RA,IL2,IL4,IL6,IL6ST,INSR,JAK,JAK1,JAK2,Jnk,JUN,LEP,LEPR,MAP2K1,MAP3K7,MAPK3,mir-21,MITF,MYOD1,NFKB2,NFKBIA,NGEF,norepinephrine,NRAS,P38 MAPK,PDPK1,PI3K (complex),Pka,PPARA,PPARGC1A,PTPN11,RICTOR,S100A9,SOCS3,SOX2,SPARC,SREBF1,STAT1,STAT3,STAT4,STAT5A,STAT5B,STAT6,TGFB1,TNFSF11,TWIST1 ABCA3,ACAA1,ADGRG6,ADRM1,AIMP2,ANGPT2,ANK1,AOC1,ARL6IP4,ATL2,B4GALT1,BCHE,C1QL1,C1QTNF3,CACHD1,CALML3,CD209,CHRNA10,CLEC10A,CLPB,CR1,CUBN,Cyp2d22,CYP39A1,DPY19L3,ETNK1,FASN,FAT4,FCGBP,FGL1,FRRS1,GLB1,GSTM3,HNRNPM,HSD3B2,KRT8,Lgals6,LGMN,LITAF,LRP4,MATR3,MKX,MMRN1,NCAN,PGK1,PIF1,PLG,POLI,PPP1CA,PTGIR,PTPRG,RAB11A,RRM2,RSL24D1,SCARF1,SERINC2,SLC5A7,SNAP25,SOD3,SVEP1,TENM3,THSD4,TMPRSS6,TNFSF14,TRIM2,VPS25,XPO7 67 (69) 62 4-phenylbutyric acid,BHLHE40,C5,CLCF1,clenbuterol,CNTF,fatty acid,Fc gamma receptor,GW3965,IL11,IL27,IL31,LIF,MAP3K8,mir-182,NFkB (complex),POU5F1,PRKAA1,prostaglandin E2,RAPGEF3,RETN,S100A9,SULF2,WNT5A BMP7,CASR,irinotecan,SPHK1,TRA,tunicamycin,USP18 PPARA AKT1,ATF3,CXCL10,Focal adhesion kinase,IRS1,ITPR1,MAP3K7,OSMR BTG2 transcription regulator 3 Activated 2.066 1.75E-04 2.48E-02 26s Proteasome,ACHE,Akt,AKT1,Ap1,APP,ATR,BTG2,CDK1,CDKN1B,CEBPA,CREB1,CTNNB1,CYP19A1,E2f,E2F3,ERBB2,ERBB3,ESR1,ESR2,ETS2,FOS,GLI1,GLI3,HIF1A,HMOX1,HRAS,IRF3,Jnk,MAPT,MDM2,NFE2L2,NFKB1,NFKBIA,NGEF,PDPK1,PGR,PPARGC1A,PTTG1,RB1,RICTOR,SOX2,STAT3,STAT5B,STK11,TSC1,TWIST1,Vegf ADRM1,AGA,AIMP2,AKNA,ANGPT2,ANGPTL3,ANOS1,ASPG,BIRC2,C1QL1,C1QTNF3,CALM1 (includes others),CD209,CELSR1,CLEC10A,CLPB,CYP39A1,DPY19L3,EMILIN2,EMX2,FASN,FAT4,GSTM3,H2BC21,HNRNPM,ITGB3,L1CAM,LRP4,MAPK4,MATR3,MEGF10,MGAT4C,MKX,MMRN1,NCAN,NUBP1,PGK1,PLG,PLIN2,POLI,PTPRK,RAB11A,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC5A7,SOD3,SUSD2,SVEP1,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TNXB,TPPP3,TRPM2,WRN 60 (48) 45 camptothecin,CDKN2A,dalfampridine,forskolin,GnRH-A,mitomycin C,SALL4 ESR2,indomethacin,l-asparaginase,L-triiodothyronine,WNT5A SOD1 CCNE1,IGFBP6,NOX4 isorhamnetin chemical - endogenous non-mammalian 2 0.943 1.76E-04 8.00E-04 Akt,CYP1A1,ERK1/2,isorhamnetin,Jnk,MAPK14,P38 MAPK AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CACHD1,CD209,CEBPD,CLEC10A,FASN,GSTM3,ITGB3,L1CAM,LRP6,PLG,RRM2,TNFSF14 18 (7) 6 GSTA1 retaspimycin chemical drug 3 -1.180 1.78E-04 2.26E-02 AHR,Akt,CD24,EGFR,ERBB2,ERK1/2,ESR2,estrogen receptor,geldanamycin,Hsp90,HSP90AA1,HSP90AB1,Jnk,KDM3A,MAPT,NCL,Nfat (family),NOS3,NR1I2,P38 MAPK,PGR,PPARA,RAF1,retaspimycin,SMAD3,STAT1,STAT3,STK11,TP53,TWIST1 ACAA1,AIMP2,ANGPT2,ANK1,AOC1,ASPG,B4GALT1,CALCRL,CASP2,CD209,CLEC10A,CSMD3,CYP39A1,DGAT1,DPY19L3,EMILIN2,FAT4,FCGBP,FLNC,GLB1,GNAO1,GSTM3,HSD3B2,KIFC1,L1CAM,MAPK4,MEGF10,PLG,PLIN2,POLI,PPP1CA,PTPRK,RRP12,SERINC2,SLC16A4,SLC16A7,SLC5A7,SNAP25,SNX33,SOD3,SYT12,TNFSF14,TNXB,TRIM2,TRIM3,TSG101 46 (30) 26 Hsp90,KIT SYNM other 2 Inhibited -2.357 1.79E-04 8.00E-04 Akt,AKT1,CDKN1A,RB1,SYNM AIMP2,ANGPT2,BIRC2,BIRC3,CALCRL,CEBPD,CELSR1,FASN,GLB1,H2BC21,HNRNPM,ITGB3,L1CAM,MAPK4,MATR3,PLG,RRM2,TNFSF14 18 (5) 4 AKT1 tyrosine kinase group 2 -1.347 1.84E-04 5.00E-03 Akt,CAV1,CYP1A1,ERBB2,ERBB3,ERK1/2,estrogen receptor,IL6ST,JAK,NFkB (complex),PIK3CA,SRC,STAT,tyrosine kinase AIMP2,ALDH7A1,ANGPT2,AOC1,BIRC2,BIRC3,CACHD1,CD209,CEBPD,CGAS,DPY19L3,FASN,FLNC,GSTM3,ITGB3,KRT8,L1CAM,LRP6,PGK1,PLG,POLI,PTPRK,RRM2,SLC5A7,SOD3,TNFSF14,TNXB 27 (14) 13 paraquat,PPARA KIT,NFkB (complex),PIK3CA,PIK3CD peptidoglycan chemical - endogenous non-mammalian 3 -0.831 1.84E-04 2.65E-02 26s Proteasome,ACHE,Akt,APP,CASP1,CASP3,CASP8,CD40,CDKN1B,CEBPA,CHUK,CREB1,CTCF,CTNNB1,CXCL8,DICER1,EIF2AK3,EIF4E,ELK1,ERK,ERK1/2,ESR2,ETS2,FADD,Focal adhesion kinase,FOS,Hdac,HIF1A,HNF1A,HNF4A,HRAS,Hsp27,IFNAR1,IFNG,IGF1,IL1,IL10,IL10RA,IL1B,IL4,IRAK1,Jnk,JUN,MAP2K7,MAPK14,MAPK3,MAPK8,MITF,MYB,MYOD1,NFATC2,NFkB (complex),NFKB1,NFKB2,NFKBIA,NOD2,NRAS,P38 MAPK,PDPK1,peptidoglycan,PI3K (complex),PPARGC1A,PRKCE,RAF1,RAS,RB1,RICTOR,S100A9,SIRT1,STK11,Tlr,TLR2,TNF,TWIST1,ZC3H12A ADGRG6,ADRM1,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,ATL2,BBX,BCHE,C1QL1,C1QTNF3,CACHD1,CD209,CEBPD,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,DGAT1,ETNK1,FAM111A,FAT4,FUT6,GNAO1,H2AC21,HCRTR2,ITGB3,KRT8,L1CAM,Lgals6,LITAF,LRP4,LRP5,LRP6,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NCAN,NLGN2,NUBP1,PIF1,PKD1L2,PLG,PNLIP,POLI,RAB11A,RRM2,RRP12,RSL24D1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SOD3,SUSD2,SVEP1,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM56,VPS25,XPO7 71 (75) 62 CASP3,CCL3L3,Focal adhesion kinase,HMOX1,IFNB1,NFkB (complex),POU2AF1,S100A9 peroxynitrite chemical toxicant 2 -1.061 1.86E-04 8.10E-03 26s Proteasome,Akt,AKT1,EGFR,ERK1/2,IKK (complex),MAP2K1,MAP2K4,MAPK1,MAPK14,MAPK8,Mmp,NFkB (complex),NFKB1,peroxynitrite,PRKAA1,PRKCZ,RAF1,STK11,TPH1 ADRM1,AIMP2,ALDH7A1,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CASP2,CD209,CEBPD,DGAT1,DUT,FLNC,GNAO1,H2BC21,HNRNPM,HSD3B2,IFI44,ITGB3,L1CAM,LGMN,LITAF,LRP6,MATR3,PGK1,PLG,PTPRK,SLC16A4,SLC16A7,TNFSF14,TNXB 32 (20) 19 N,N-dimethylarginine propofol AKT1,CASP3,iron,NFkB (complex),PRKAA1 SLC6A3 pregnenolone sulfate chemical - endogenous mammalian 3 -1.300 1.89E-04 5.00E-03 Calcineurin protein(s),CaMKII,Creb,CREB1,DUSP1,ERK,ERK1/2,GABA-A receptor,GRIN3A,L-glutamic acid,MAPK1,MAPK14,MAPT,Nfat (family),NMDA Receptor,NRAS,NTRK2,P38 MAPK,Pkc(s),pregnenolone sulfate,SRC ADGRG6,ANGPT2,ANK1,AOC1,ASPG,BIRC2,BIRC3,CALCRL,CEBPD,CLEC10A,DPY19L3,FLNC,HCRTR2,IFI44,ITGB3,KRT8,LITAF,LRP6,MGAT4C,PGK1,PLIN2,PTPRK,RRM2,SERINC2,SNAP25,TNFSF14,TSG101,TULP4,VPS25 29 (21) 18 acetylcholine,Ca2+,NMDA Receptor 3-hydroxyanthranilic acid chemical - endogenous mammalian 3 -0.816 1.92E-04 3.22E-02 3-hydroxyanthranilic acid,AHR,Akt,AKT1,CCND1,CEBPA,CSF2,CXCL8,cytokine,EGFR,ERK,ERK1/2,estrogen receptor,HIF1A,HNF4A,IKBKB,IL1B,IL6,IRF3,Jnk,JUN,MAPT,MYC,NFkB (complex),NFKB1,NFKB2,NOS2,NR1I2,PDPK1,POU2F2,PPARG,PPARα-RXRα,PRKCE,PTGS2,REL,SMAD3,SP1,STAT1,STAT5A,TP53 ACAA1,ADGRG6,AGA,AIMP2,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,ASPG,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALCRL,CD209,CEBPD,CELSR1,CHRNB3,CR1,CSMD3,CYP39A1,EMILIN2,FASN,FGL1,FLNC,FUT6,GLB1,GNAO1,GSTM3,H2BC21,HNRNPM,HSD3B2,ITGB3,KIFC1,LGMN,LRP6,MATR3,MMRN1,PGK1,POLI,PTPRK,RAB11A,REG1A,SLC16A4,SLC16A7,SOD3,SYT12,TMPRSS6,TNFSF14,TNXB,TRAF3IP2,TSG101,WRN 54 (40) 39 HMOX1 NFkB (complex) MCTS1 other -0.000 2 -0.905 1.93E-04 7.00E-04 AKT1,COP1,MCTS1,MDM2 BIRC3,CASP2,CEBPD,FASN,H2BC21,HNRNPM,MATR3,PLG,SYT12,TSG101,WRN 11 (4) 3 ammonium AKT1,MDM2 D-2-amino-5-phosphonovaleric acid chemical reagent 3 0.522 1.93E-04 8.40E-03 Calcineurin protein(s),CaMKII,CREB1,CSF2,D-2-amino-5-phosphonovaleric acid,DUSP1,ERK,ERK1/2,GATA4,GRIN3A,L-glutamic acid,MAP2,MAPK1,MAPK14,MEF2D,Nfat (family),NFAT5,NFATC1,NFATC2,NMDA Receptor,NRAS,NTRK2,P38 MAPK,Pkc(s),RGS4,SRC,SRC (family),SYN1 ADGRG6,ANGPT2,ANK1,AOC1,B4GALT1,BBX,BIRC2,BIRC3,CALCRL,CASP2,CD209,CEBPD,CLEC10A,EMX2,FLNC,HCRTR2,HSD3B2,ITGB3,KRT8,LITAF,LRP6,MEGF6,MGAT4C,PGK1,PLIN2,SERINC2,SNAP25,SOD3,SSPOP,TNFSF14,TSG101,TULP4,VPS25 33 (28) 24 Ca2+,NMDA Receptor mitomycin C chemical drug 3 -1.673 1.94E-04 3.32E-02 Ap1,APP,AR,ATF4,ATM,BCL2L1,BHLHE40,CASP3,CASP8,CDKN1B,CDKN2A,CEBPA,COP1,Creb,CREB1,CTNNB1,DICER1,EIF2A,EIF2AK3,EIF4E,EIF4EBP1,ERBB2,ERN1,ESR1,ESR2,estrogen receptor,FADD,FOS,GLI1,HIPK2,HNF1A,HNF4A,IL1B,IL6,IRF7,Jnk,KRT8,MAPK1,MAPK10,MAPK11,MAPK12,MAPK13,MAPK14,MAPK8,MAPK9,mitomycin C,MYOD1,NFATC2,PARP1,PGR,PPARA,PPARGC1A,PPIF,PRKCE,RICTOR,RNASEL,RXRA,S100A9,SIRT1,SMARCA4,SPP1,STAT4,TGFB1,TNF,TP53,TWIST1 ANGPTL3,ANK1,B4GALT1,BBX,BCHE,BIRC2,BIRC3,C1QTNF3,CALCRL,CALM1 (includes others),CALML3,CASP2,CD209,CELSR1,CHAC1,CHRNB3,CLEC10A,CLPB,CSMD3,Cyp2d22,CYP39A1,DGAT1,DPY19L3,DUT,EMILIN2,ETNK1,FAM111A,FAT4,FGL1,FLNC,FUT6,GLB1,GSTM3,HCRTR2,IFI44,KIFC1,Lgals6,LRP5,LRP6,MEGF10,MGAT4C,MMRN1,NLGN2,NUBP1,PIF1,PKD1L2,PLG,PNLIP,POU3F3,PPP1CA,REG1A,RRP12,RSL24D1,SCARF1,SERINC2,SLC5A7,SOD3,SUSD2,SVEP1,SYT12,THSD4,TNR,TPPP3,TRAF3IP2,TRIM36,TRIM56,TRPM2,TSG101,TULP4,XPO7 70 (66) 56 POR,suramin,XDH ATF3,BTG2,CASP3,ERN1,FASLG,MDM2,POU5F1,PPP1R15A PAK2 kinase 0.000 3 -0.944 1.94E-04 1.60E-02 ABL1,Akt,APP,ATF4,AURKA,AURKB,CDKN2A,CEBPA,CTNNB1,EIF2AK3,EIF2AK4,ERK,FADD,GLI1,HIF1A,HIPK2,HNF1A,HNF4A,IFNAR1,IGF1,Jnk,JUN,KRT8,MAPK10,MAPK12,MAPK14,MAPK8,MAPK9,MITF,MYB,MYC,MYOD1,NEDD9,Nfat (family),NGEF,P38 MAPK,PAK2,PDPK1,RAC1,RAF1,RICTOR,RXRA,SIRT1,SNCA,SPP1,STK11,TCF7L2,TNF ABCA3,ADGRG6,AIMP2,ANGPT2,ANGPTL3,ANK1,ATL2,B4GALT1,BIRC3,C1QTNF3,CD209,CGAS,CHAC1,CLEC10A,CYP39A1,DGAT1,EMX2,ETNK1,FAM111A,FGL1,FUT6,HCRTR2,IFI44,KMT5A,L1CAM,Lgals6,LGMN,LRP6,MEGF11,MMRN1,PGK1,PIF1,PKD1L2,PLG,PLIN2,PNLIP,POLI,RAB11A,REG1A,RRM2,RSL24D1,SCARF1,SLC16A4,SLC16A7,SOD3,SUSD2,TMPRSS6,TNFSF14,TNR,TPPP3,TRIM3,TRIM56,TULP4,WRN,XPO7 55 (48) 43 caspase,fatty acid,INS,lactacystin,NET1,phospholipid,PIK3CG,PPARD FRAX-597 NOX4,PGR,ZEB2 Cofilin,MDM2,PROX1 TEX11 other -0.000 2 0.229 1.95E-04 2.70E-03 Akt,ERK,ESR2,TEX11 ADGRG6,AIMP2,ANK1,B4GALT1,BIRC2,CEBPD,DUT,GLB1,IFI44,ITGB3,KRT8,L1CAM,MAPK4,MEGF10,PLG,RRM2,RRP12,SLC5A7,TNFSF14 19 (4) 3 ESR2 beta-naphthoflavone chemical toxicant 3 -1.500 1.96E-04 3.00E-02 2-amino-1-methyl-6-phenylimidazo-4-5-b-pyridine,26s Proteasome,AHR,AKT1,androstenedione,APP,AR,ARNT,benzo(a)pyrene,beta-naphthoflavone,Calcineurin protein(s),CEBPA,CHRNA7,CYP19A1,CYP1A1,CYP1A2,dextromethorphan,diclofenac,DIO2,EGFR,EIF2AK3,EIF4E,ESR2,FADD,FOXO1,GLI1,GST,GSTK1,GSTO1,HIF1A,HRAS,IGF1,IL22,IL6,Jnk,JUN,KAT5,KRT8,LEP,MAPT,MITF,MYB,MYC,NFATC2,NFE2L2,NR1I3,P38 MAPK,phenacetin,PPARGC1A,propranolol,RAF1,RICTOR,S100A9,STAT1,testosterone,TNF,TP53,TP73,TWIST1 ADRM1,ALDH7A1,ANK1,ASPG,ATL2,BBX,BCHE,BIRC3,C1QTNF3,CACHD1,CALML3,CASP2,CD209,CEBPD,CGAS,CHAC1,CHRNA10,CLEC10A,CSMD3,Cyp2d22,CYP39A1,EMILIN2,ETNK1,FAT4,FCGBP,FGL1,GNAO1,GSTM3,HCRTR2,HSD3B2,L1CAM,MATR3,MEGF10,MMRN1,NLGN2,PGK1,PIF1,PLG,PLIN2,PNLIP,POLI,POU3F3,PPP1CA,RAB11A,REG1A,RRP12,RSL24D1,SLC16A4,SLC16A7,SLC5A7,SOD3,SVEP1,SYCE2,SYT12,TENM3,THSD4,TMPRSS6,TNR,TNXB,TPPP3,TRIM56,TSG101,TULP4,WRN 64 (59) 53 benzo(a)pyrene,GSTA1,lauric acid SAA1 NPY other 3 -0.126 1.97E-04 1.42E-02 ACHE,Akt,APP,CaMKII,CDKN1B,CEBPA,CFTR,CLOCK,COP1,CREB1,CTNNB1,DDX41,EGFR,EIF2AK3,EIF4E,ELAVL1,ERK,ERK1/2,ESR1,ESR2,ETS2,FOS,FSH,G protein,GNRH1,HIF1A,HNF1A,HNF4A,HRAS,IFNG,IL10,ITGB1,MAPK1,MAPK14,MAPK3,MAPK8,MAPT,MITF,MYB,MYC,MYCN,MYOD1,NGEF,NPY,PARP1,PGR,PPARA,PPARGC1A,PRKCA,RAF1,RAPGEF3,RICTOR,RXRA,S100A9,SIRT1,SLC9A3R1,TGFB1,TNS1 ADAMTS16,ADGRG6,AIMP2,ANGPT2,ANGPTL3,AOC1,ASPG,B4GALT1,BCHE,BIRC2,BIRC3,CACHD1,CALML3,CEBPD,CGAS,CHAC1,CLPB,CR1,CUBN,DGAT1,EMILIN2,FASN,FGL1,FLNC,FUT6,GSTM3,H2AC21,HCRTR2,HSD3B2,IFI44,ITGB3,KRT8,L1CAM,Lgals6,LRP6,MEGF10,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PIF1,PKD1L2,PLG,PNLIP,PTPRK,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A7,SLC5A7,SUSD2,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TNXB,TPPP3,TRPM2,TULP4 63 (58) 51 6-hydroxydopamine,amitriptyline,ASIP,etoposide,forskolin,GDF2,IL20,pilocarpine,RETN CNTF,cocaine,dorsomorphin,ESR2,INS,oleic acid,PPARD,RXRA,vildagliptin G protein,LPIN1 DDX41,levothyroxine,RAPGEF3 tozasertib chemical drug 2 1.807 1.97E-04 1.20E-03 AKT1,AURK,AURKB,CDK2,Histone h3,RB1,tozasertib ANGPT2,ANK1,BIRC3,CALCRL,CEBPD,CELSR1,CSMD3,FASN,H2BC21,HNRNPM,MAPK4,MATR3,PLG,RRM2,SNAP25 15 (7) 6 CASP3 AKT1 Fc gamma receptor group 3 -0.243 1.97E-04 1.62E-02 26s Proteasome,Akt,AKT1,APP,CBL,CD36,CDKN1B,CREB1,CTNNB1,CXCL8,doxorubicin,EIF2AK3,EIF4E,EPAS1,ERK,ETS2,FADD,Fc gamma receptor,FOS,FYN,GAB2,HIF1A,HNF4A,HRAS,IGF1,IKZF1,IL10,IL1B,IL6,IL6ST,INSR,Jnk,LAT,LYN,Mapk,MAPK1,MAPK3,MITF,MYOD1,NFkB (complex),NGEF,nitric oxide,NOS3,NRAS,P38 MAPK,PAK1,PDPK1,PI3K (complex),PLC,Pld,PPARA,PPARGC1A,PRKCE,RB1,REL,RICTOR,S100A9,SNCA,SOX2,SPARC,STK11,SYK,SYK/ZAP,TGFB1,TNF,TNFSF11,TWIST1 ADGRG6,ADRM1,AGA,AIMP2,ALDH7A1,ANGPT2,ANK1,ATL2,B4GALT1,BCHE,C1QL1,CALCRL,CALML3,CD209,CEBPD,CELSR1,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,DGAT1,ETNK1,FASN,FCGBP,FGL1,FLNC,FRRS1,FUT6,H2BC21,HNRNPM,IFI44,ITGB3,KMT5A,L1CAM,Lgals6,LRP4,MAPK4,MATR3,MEGF11,MGAT4C,MKX,NLGN2,NUBP1,PIF1,PLG,PNLIP,PTPRK,RAB11A,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SOD3,SUSD2,SVEP1,TENM3,THSD4,TMPRSS6,TNFSF14,TPPP3,TRAF3IP2,TRIM2,TRIM3,TRIM56,VPS25 68 (67) 55 IgG AKT1,CCNE1,LCP2,NFkB (complex),SOCS3 PELI3 enzyme 3 Inhibited -2.023 1.98E-04 2.81E-02 AHR,AKT1,APP,ATF4,CEBPA,COP1,Creb,CXCL8,EGFR,EIF4E,ELK1,ERK,FADD,FOS,HIF1A,HIPK2,HNF4A,IKK (complex),IL6,IRAK1,Jnk,JUN,MAP3K7,MAPT,MYC,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,PELI3,PPARGC1A,RB1,RICTOR,RXRA,TAB1,TGFB1,TNF,TWIST1,ZC3H12A ABCA3,ADGRG6,ALDH7A1,ANGPTL3,ASPG,B4GALT1,C1QTNF3,CALML3,CD209,CEBPD,CHAC1,CLEC10A,CR1,CYP39A1,DPY19L3,EMILIN2,ETNK1,FAM111A,FAT4,FCGBP,FGL1,FUT6,GNAO1,GSTM3,HNRNPM,IFI44,ITGB3,KRT8,L1CAM,LGMN,LITAF,MAPK4,MATR3,MMRN1,NCAN,NLGN2,NUBP1,PGK1,PLG,POLI,POU3F3,RRM2,RSL24D1,SLC16A4,SLC16A7,SOD3,SVEP1,SYT12,THSD4,TMPRSS6,TNR,TNXB,TPPP3,TRIM56,XPO7 55 (40) 35 MAP3K7,NFkB (complex) MAPK7 kinase -0.000 3 0.372 1.98E-04 3.11E-02 26s Proteasome,AKT1,ALK,APP,ARNTL,ATF4,CDKN2A,Creb,CXCL8,EGFR,EIF2AK4,EIF4E,ESR2,ETS1,ETS2,FOS,GATA6,HNF4A,HRAS,IL1B,IL2,IL6,ITGB1,JUN,Mapk,MAPK7,MEF2C,MEF2D,MYB,MYC,MYOD1,NFATC2,NFE2L2,NFkB (complex),NFKB1,NR1I2,PAWR,PDPK1,PPARG,PPARGC1A,PPP3R1,progesterone,PTGS2,PTK2,RB1,REL,RELA,RHOA,RUNX1,SOX2,SPARC,STAT5B,STUB1,TGFB1,TNFSF11,TWIST1 ABCA5,ACAA1,ADRM1,AGA,AIMP2,ALDH7A1,ANGPT2,B4GALT1,BBX,BCHE,BIRC3,C1QL1,CALCRL,CALML3,CD209,CELSR1,CGAS,CHAC1,CR1,CYP39A1,DGAT1,DPY19L3,EMX2,FAM111A,FASN,FAT4,FCGBP,Fcna,FGL1,FRRS1,FUT6,GNAO1,H2BC21,HCRTR2,HNRNPM,ITGB3,L1CAM,Lgals6,LGMN,LRP4,MAPK4,MATR3,MKX,NLGN2,NUBP1,PLG,PLIN2,POLI,POU3F3,PTGIR,RAB11A,RRM2,RRP12,SLC16A7,SLC5A7,SOD3,SVEP1,TENM3,THSD4,TNR,TNXB,TRAF3IP2,TRIM2,TULP4,WRN 65 (56) 52 Dynamin,forskolin,GAST,KIT,MAP2K4/7,MAP3K20,MAP3K8,NRG (family),sorbitol mir-145,prostaglandin E2 ACSS2,AKT1,CXCL10,Focal adhesion kinase,HMOX1,IFNB1,NFkB (complex),PPP3R1 CDH2 PBK kinase 2 -1.528 2.02E-04 1.60E-03 Akt,Ap1,DUSP1,JUN,MAPK8,NFKBIA,P38 MAPK,PBK AIMP2,ANK1,B4GALT1,BIRC3,CALM1 (includes others),CEBPD,CLEC10A,DGAT1,IFI44,ITGB3,KRT8,L1CAM,LITAF,NCAN,PLG,PLIN2,POLI,PTPRK,RRM2,SOD3,TNFSF14 21 (8) 8 RABGEF1 enzyme -0.000 2 1.698 2.03E-04 9.00E-04 Akt,ERK,ERK1/2,Jnk,RABGEF1,RAS ADGRG6,AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,L1CAM,LGMN,PLG,RRM2,TNFSF14,TRIM3 17 (6) 6 ARR3,Rab5 CXCL10,IFNB1 HSPB1 other 3 0.000 2.12E-04 6.70E-03 26s Proteasome,ACHE,Akt,CASP3,CASP8,CEBPA,DICER1,DLX5,EIF4E,ELAVL1,ERK1/2,ESR2,ETS2,FADD,Hdac,HNF1A,HNF4A,HSF1,HSPB1,IFNAR1,IGF1,IL10,IL1B,JUN,KRT8,MAP2K4,MAP2K7,MAP3K5,MAPK14,MITF,MYB,MYOD1,NFATC2,NGEF,NR1I3,P38 MAPK,PDPK1,PRKCD,PRKD1,RXRA,SIRT1,SPP1,TFRC,TGFB1,TNF ADRM1,AIMP2,ANGPT2,ANGPTL3,ANK1,AOC1,ATL2,BBX,BIRC3,CACHD1,CALML3,CELSR1,CGAS,CHAC1,CR1,CYP39A1,ETNK1,FASN,FGL1,FUT6,HCRTR2,ITGB3,L1CAM,Lgals6,LRP4,LRP5,LRP6,MKX,MMRN1,NLGN2,PGK1,PIF1,PKD1L2,PLG,POLI,POU3F3,RAB11A,REG1A,RRM2,RRP12,SCARF1,SLC5A7,THSD4,TNFSF14,TNR,TRAF3IP2,TRIM56,TULP4 48 (45) 39 ATF3,camptothecin,fatty acid,lactacystin,lith-O-Asp,NFkB (complex),sorbitol,SYVN1 BMP7,caffeic acid phenethyl ester,CDK4/6,IgG,UBA1 CASP3,caspase TERT enzyme 2 0.447 2.13E-04 1.90E-03 CTNNB1,EIF4EBP1,IRF3,NOS3,RB1,TERT ACAA1,ANGPT2,ANOS1,BIRC2,BIRC3,CALCRL,CEBPD,CELSR1,EMX2,FASN,GLB1,H2BC21,IFI44,KIFC1,L1CAM,MAPK4,PGK1,PLIN2,SOD3,SUSD2 20 (6) 6 AKT1,anisomycin,calcium chloride,DETA-NONOate,doramapimod,EP300,EPAS1,ETV1,NFkB (complex),phorbol 12,13-dibutyrate,phytohemagglutinin,S100A9,TFAP2B,WNT1,WNT3A Ca2+,costunolide,daunorubicin,etoposide,histone deacetylase inhibitor,MAP3K7,MDM2,NMI,PPARA,tacrolimus,tanespimycin,WNT5A,ZEB2 ATF3,CX3CL1,CXCL10,DDX41,IFNB1,KRT18,POU5F1 CASP3,CDH2 CALM1 (includes others) other -0.699 3 0.651 2.14E-04 4.32E-02 AHR,AKT1,CALM1 (includes others),CAMK2A,CAMK2G,CAMK4,CAMKK1,CDKN1B,CEBPA,CEBPB,CREB1,CSF2,CTNNB1,CXCL8,cytokine,doxorubicin,EGFR,ERK,estrogen receptor,Hdac,HIF1A,HNF4A,IL1B,IL6,INSR,IRF3,JUN,MAP3K7,MYOD1,NFkB (complex),NFKB1,NFKB2,NFKBIA,nitric oxide,NOS3,NR1H2,NR1I2,NR4A1,POU2F2,PPARG,PPARα-RXRα,PRKCE,RARA,REL,SMAD3,STAT3,STAT4,STAT5A,TERT,TP53,VitaminD3-VDR-RXR ABCA3,ACAA1,ADGRG6,AGA,ALDH7A1,ANK1,ANOS1,AOC1,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALCRL,CD209,CELSR1,CHRNB3,CLEC10A,CLPB,CR1,CSMD3,Cyp2d22,CYP39A1,DUT,EMILIN2,FCGBP,FGL1,FLNC,FUT6,GNAO1,H2BC21,HNRNPM,HSD3B2,IFI44,KMT5A,Lgals6,LGMN,LITAF,LRP4,LRP5,LRP6,MATR3,MGAT4C,MMRN1,NCAN,PLG,POLI,PPP1CA,PTPRK,REG1A,RRM2,SERINC2,SLC16A4,SOD3,SUSD2,SYT12,TMPRSS6,TNXB,TRAF3IP2,TSG101 59 (51) 47 forskolin,SYVN1 METTL5,tanespimycin NFkB (complex) PGR phenformin chemical drug 3 -1.605 2.14E-04 2.04E-02 ACACB,AKT1,AMPK,Ap1,ATF4,CDKN1B,CEBPB,CFTR,CTNNB1,EIF2AK3,ELAVL1,ERK,ERN1,FLCN,FMR1,FOS,HIF1A,HIPK2,HNF4A,HRAS,IFNAR1,INSR,MAPK1,MAPK3,MAPK8,MDM2,MED1,MKNK1,MLXIPL,NFkB (complex),NFKB1,NFKB2,phenformin,PPARA,PPARGC1A,PRKAA1,PRKAA2,PRKACA,PRKCE,RARB,RB1,RICTOR,RNASEL,RPS6KB1,SLC6A4 ACAA1,ADGRG6,AGA,ALDH7A1,ANGPTL3,B4GALT1,BIRC2,BIRC3,C1QTNF3,CACHD1,CALM1 (includes others),CEBPD,CGAS,CHAC1,CHRNB3,CLPB,CUBN,DGAT1,EMILIN2,EMX2,FAT4,FCGBP,FLNC,FUT6,GNAO1,H2BC21,HNRNPM,HSD3B2,IFI44,LGMN,LITAF,MAPK4,MATR3,NUBP1,PLIN2,PNLIP,PTPRK,REG1A,RSL24D1,SUSD2,SVEP1,SYCE2,TENM3,TKFC,TMPRSS6,WRN,XPO7 47 (45) 40 ERN1,PRKAA1,SLC2A1 dATP,RPS6KB1 CC 401 chemical drug 3 0.525 2.20E-04 3.47E-02 AKT1,Ap1,APP,AR,Calcineurin protein(s),CC 401,CDKN1B,Creb,CREB1,CTNNB1,DYRK1A,DYRK1B,EIF2AK3,EIF4E,EPAS1,ERK1/2,estrogen receptor,FADD,FOS,GLI1,HNF1A,HRAS,INSR,Jnk,KRT8,MAPT,MYC,NFkB (complex),RBL2,RICTOR,RXRA,SIRT1,SMAD3,SNCA,TNF,TP53,TWIST1 ABCA3,ADGRG6,ALDH7A1,ANGPTL3,AOC1,ASPG,BIRC3,C1QTNF3,CALM1 (includes others),CD209,CHAC1,CLEC10A,CLPB,CSMD3,Cyp2d22,DPY19L3,DUT,EMX2,ETNK1,FAT4,FCGBP,FGL1,FLNC,FUT6,GSTM3,HCRTR2,HNRNPM,KIFC1,LGMN,LITAF,MATR3,MEGF11,MGAT4C,NCAN,NLGN2,NUBP1,PKD1L2,PLG,PNLIP,POU3F3,PPP1CA,PTPRK,REG1A,RSL24D1,SERINC2,SLC16A7,SOD3,SUSD2,TENM3,THSD4,TMPRSS6,TNR,TPPP3,TRIM3,TRIM56,TRPM2,TSG101,WRN 58 (37) 35 MAP3K20 kinase 0.000 3 -1.612 2.21E-04 3.04E-02 APP,ATF2,ATF4,CDKN1B,CDKN2A,CEBPA,Creb,CREB1,CTNNB1,CYP19A1,EIF2AK3,EIF2AK4,EIF4E,ELK1,ERK,FADD,FOS,GLI1,HIF1A,IFNAR1,IGF1,IRF3,Jnk,JUN,KRT8,MAP2K3,MAP3K20,MAPK12,MAPK14,MAPK7,MAPK8,MAPT,MDM2,MITF,MYB,MYC,MYOD1,NFATC2,NFkB (complex),P38 MAPK,PGR,PPARA,PPARGC1A,PPP3R1,RB1,RICTOR,RXRA,S100A9,SIRT1,SPP1,TNF,TWIST1 ABCA3,ABCA5,ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANGPTL3,ANK1,ANOS1,ASPG,ATL2,B4GALT1,BBX,BCHE,BIRC2,BIRC3,C1QTNF3,CD209,CGAS,CHAC1,CLEC10A,CLPB,CYP39A1,DGAT1,DPY19L3,EMILIN2,EMX2,ETNK1,FAM111A,FAT4,GSTM3,H2BC21,HCRTR2,IFI44,ITGB3,Lgals6,LGMN,LRP6,MAPK4,MEGF10,MGAT4C,MMRN1,NLGN2,NUBP1,PGK1,PIF1,PLG,PNLIP,POLI,POU3F3,REG1A,RRM2,RSL24D1,SERINC2,SLC16A4,SLC16A7,SUSD2,SVEP1,THSD4,TMPRSS6,TNR,TPPP3,TRIM56,TULP4,WRN 65 (52) 46 ATF2,MAP2K4/7,MAPK7 GPSM1 other 3 Inhibited -2.100 2.22E-04 1.60E-02 26s Proteasome,ACHE,ADCY1,Akt,Ap1,AR,CDKN1B,CEBPA,CFTR,COP1,CTNNB1,DLX5,ERK1/2,ESR2,ETS2,FMR1,FOS,GPSM1,IGF1,IL10,IRF3,ITGB1,MAPK14,MITF,MTOR,MYB,NFATC2,NFKBIA,NGEF,NR1I3,P38 MAPK,PDPK1,PGR,PPARA,PPARGC1A,RB1,RICTOR,RPS6KB1,S100A9,SIRT1,TSC1,TSC2,TWIST1,Vegf ADRM1,AGA,AIMP2,ANGPT2,ANK1,ANOS1,AOC1,ATL2,BBX,BCHE,BIRC2,BIRC3,CALM1 (includes others),CEBPD,CLPB,CR1,CUBN,Cyp2d22,CYP39A1,EMILIN2,FASN,FAT4,FCGBP,GSTM3,HCRTR2,IFI44,ITGB3,L1CAM,LRP6,MAPK4,MEGF10,MKX,MMRN1,NCAN,NUBP1,PIF1,PLG,POU3F3,RAB11A,RRM2,RRP12,RSL24D1,SCARF1,SLC5A7,SUSD2,SVEP1,SYCE2,SYT12,THSD4,TNFSF14,TULP4 51 (44) 41 cocaine GNAI3 RPS6KB1 INS other 2 -1.809 2.22E-04 2.58E-02 26s Proteasome,Akt,AKT1,CREB1,CTNNB1,ERK,ERK1/2,FOXA2,FOXO1,GATA2,INS,INSR,Jnk,MAPK1,MAPK14,MAPK3,MAPK8,NFkB (complex),NRAS,P38 MAPK,PAK2,PDPK1,PRKCZ,RB1,RICTOR,STAT5B ACAA1,ADGRG6,ADRM1,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,CASP2,CD209,CELSR1,CLEC10A,CYP39A1,EMX2,FASN,FCGBP,FLNC,GSTM3,H2BC21,HNRNPM,HSD3B2,ITGB3,KIFC1,LITAF,LRP6,MAPK4,MATR3,MGAT4C,MMRN1,PGK1,PLG,PLIN2,PTPRK,RAB11A,RSL24D1,SERINC2,SOD3,SUSD2,TNFSF14,TRPM2,TULP4,VPS25,WRN 44 (26) 26 EP300,urea FGF7,L-triiodothyronine,prednisolone,tacrolimus,tunicamycin ADAM10,AKT1,CIDEC,ERN1,Na+,K+ -ATPase,NFkB (complex),PAK2,PIK3CA,RPS6KB1,RPS6KB2,SLC2A1,SSTR5 Ca2+,fatty acid,FOXO4,GABARAPL1,IRS,miR-133a-3p (and other miRNAs w/seed UUGGUCC),NPY,SCD,SOD1,TFAM CDH5 other 3 0.714 2.28E-04 1.64E-02 ACHE,Akt,Alpha catenin,ATF4,CDH5,CEBPB,CTNNB1,CYP19A1,DLX5,ESR2,FOXO1,HRAS,IRF3,ITGB1,MAPK8,MAPT,MLXIPL,MYC,NEDD9,NGEF,NR1I2,PPARG,PPARGC1A,PTK2B,RAC1,RB1,REL,SHC1,SIRT1,SMAD3,SNCA,STAT5B,TCF7L2,TWIST1,VDR ABCA3,ACAA1,AGA,AIMP2,ANGPTL3,ANOS1,ASPG,BIRC2,BIRC3,C1QTNF3,CASP2,CEBPD,CHAC1,CUBN,CYP39A1,DGAT1,EMILIN2,EMX2,FASN,FAT4,FCGBP,GSTM3,HCRTR2,ITGB3,KIFC1,KMT5A,L1CAM,LGMN,LRP6,MAPK4,MEGF10,MEGF11,MMRN1,PGK1,PLG,PLIN2,POU3F3,RRM2,RRP12,SCARF1,SLC5A7,SUSD2,SVEP1,TENM3,TKFC,TNFSF14,TNXB,TPPP3,TRIM3 49 (35) 31 ANGPT1,ENG,KU-55933,LIF,PD173074,PIK3CA,RAC2 ADAM10,FOXO4 Pak Mt group 3 0.882 2.31E-04 2.76E-02 ACHE,Akt,AKT1,Ap1,CASP3,CDKN1B,CDKN2A,CEBPA,COP1,DICER1,doxorubicin,EGFR,EIF2AK3,EIF4E,ERK,ESR1,ESR2,FADD,FOS,GLI1,GSK3B,HNF1A,HNF4A,IL6,INSR,IRF3,Jnk,KLF6,KRT8,LGALS3,MAPK14,MITF,Mt,Mt3,MYOD1,NOS3,PPARGC1A,PPIF,PRKCE,PSEN1,RICTOR,RXRA,S100A9,SIRT1,SPP1,TGFB1,TNF,TP53,TWIST1,Vegf ADGRG6,ADRM1,AIMP2,ANGPTL3,ANK1,ANOS1,BCHE,C1QTNF3,CALCRL,CALM1 (includes others),CALML3,CASP2,CD209,CEBPD,CELSR1,CHRNB3,CLEC10A,CLPB,CSMD3,CYP39A1,DUT,EMILIN2,ETNK1,FAM111A,FASN,FAT4,FCGBP,FGL1,FUT6,GLB1,HCRTR2,HNRNPM,ITGB3,KIFC1,KMT5A,L1CAM,Lgals6,LRP5,LRP6,MATR3,MEGF10,MMRN1,NLGN2,NUBP1,PIF1,PKD1L2,PLG,PNLIP,PPP1CA,PRKCSH,REG1A,RRP12,RSL24D1,SLC5A7,SOD3,SVEP1,SYT12,TNFSF14,TNR,TNXB,TRIM56,TRPM2,TSG101 63 (50) 47 HNF4A,IL27,iron,sodium arsenate carbon tetrachloride Ca2+,TFAM CASP3,ERN1 YES1 kinase -0.000 3 0.630 2.32E-04 1.73E-02 AGT,AKT1,APP,ARNTL,CBL,CDKN1B,CREB1,CTNNB1,CXCL8,EGFR,EIF4E,ELAVL1,EPAS1,ERK1/2,ESR2,ETS2,FAS,FOS,HIF1A,HNF4A,HRAS,IFNG,IL10,IL1B,IL6,IL6ST,IRF3,ITGB1,Jnk,Mapk,MAPK8IP1,MITF,NEDD9,NFATC2,NFkB (complex),NRAS,PDPK1,PI3K (complex),PPARA,PRKCD,PTK2B,REL,RICTOR,SNCA,SOX2,SPARC,STK11,TCF7L2,TNF,TNFSF11,TWIST1,VDR,WBP2,YAP1,YES1 ACAA1,ADRM1,AGA,ALDH7A1,ANGPT2,ANOS1,AOC1,B4GALT1,BBX,BIRC2,C1QL1,CACHD1,CD209,CGAS,CHAC1,CLEC10A,CLPB,CR1,CUBN,EMX2,FAT4,FCGBP,FGL1,FRRS1,FUT6,H2AC21,HCRTR2,HNRNPM,KIFC1,KMT5A,L1CAM,LRP4,LRP6,MATR3,MEGF11,MGAT4C,MKX,NLGN2,NUBP1,PGK1,PIF1,PLG,PLIN2,POU3F3,RAB11A,RRM2,RRP12,RSL24D1,SERINC2,SLC16A4,SOD3,SSPOP,SUSD2,SVEP1,TENM3,THSD4,TMPRSS6,TPPP3,TRAF3IP2,TRIM2,TRIM3,TRIM56,VPS25 63 (55) 47 Ca2+,CRKL,FASLG,leukotriene B4,POU5F1,RELN,WNT5A mir-145 AKT1,NFkB (complex) leucine chemical - endogenous mammalian 3 -0.729 2.37E-04 9.60E-03 26s Proteasome,ACHE,AKT1,AMPK,APP,CDKN2A,CEBPA,EIF2AK3,EIF2AK4,ELAVL1,ERK1/2,ESR2,ETS2,FMR1,GSK3B,Hdac,HNF4A,HRAS,INSR,IRF3,KLF6,leucine,LGALS3,LIPE,MAPT,MITF,MLXIPL,MTOR,MTORC1,naringin,NFATC2,NFKBIA,NRAS,ODC1,p70 S6k,PAWR,PAX6,PI3K (complex),PPARGC1A,REL,RICTOR,RPS6KB1,RPTOR,SESN2,SOX2,SPARC,SREBF2,STAT5B,TNFSF11,TWIST1 ADRM1,AGA,ANGPT2,ANOS1,AOC1,ASPG,BBX,BIRC2,C1QL1,CACHD1,CHAC1,DGAT1,EMILIN2,FAM111A,FASN,FAT4,FCGBP,FRRS1,FUT6,HNRNPM,HSD3B2,ITGB3,LRP4,MATR3,MKX,MMRN1,NCAN,PIF1,PLG,PLIN2,PNLIP,POU3F3,PRKCSH,REG1A,RRP12,RSL24D1,SLC5A7,SVEP1,SYCE2,TENM3,THSD4,TKFC,TNR,TPPP3,TRIM2,TULP4,VPS25 47 (50) 40 4-phenylbutyric acid AKT1,Ca2+,PPARA,RPS6KB1 ATF2,ATF3,p85 (pik3r),PPP1R15A caspase group 3 0.980 2.38E-04 1.37E-02 26s Proteasome,ACHE,AHR,Akt,APP,ATF3,CASP1,CASP3,CASP4,CASP8,caspase,Cdk,CDKN2A,CXCL8,DICER1,DLX5,EIF2AK2,EIF2AK3,EIF4E,ERK1/2,ESR2,ETS2,FADD,FOS,HNF4A,IL1,IL10,IL1B,IL6,Jnk,MAP3K1,MAPK8,MITF,MYOD1,NFATC2,NFkB (complex),NFKB2,NGEF,PAK2,PPARGC1A,RB1,REL,RICTOR,ROCK1,RXRA,STAT1,STK24,TNF ADRM1,AGA,AIMP2,ALDH7A1,ANGPTL3,AOC1,B4GALT1,BBX,BIRC3,C1QTNF3,CALCRL,CASP2,CD209,CEBPD,CELSR1,CLEC10A,CR1,EMILIN2,ETNK1,FAM111A,FASN,FGL1,FUT6,H2BC21,ITGB3,L1CAM,Lgals6,LRP5,MAPK4,MEGF10,MKX,NLGN2,NUBP1,PIF1,PNLIP,POU3F3,RAB11A,RRP12,RSL24D1,SCARF1,SLC5A7,SOD3,SVEP1,SYT12,THSD4,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM56,WRN 51 (48) 42 1-methyl-4-phenylpyridinium,3-methyladenine,6-hydroxydopamine,anisomycin,benzo(a)pyrene,bile acid,Ca2+,camptothecin,CDKN2A,ceramide,citalopram,CLEC7A,dATP,daunorubicin,DIABLO,etoposide,FASLG,gambogic acid,IL11,indomethacin,iron,lactacystin,MEN1,PDCD6,PRNP,sanguinarine,SOX7,tacrolimus,tolfenamic acid,WNT3A AKT1,CARD8,EP300,GPI,HSPB1,MDM2,mir-154,PD 169316,PEA15,POR,quercetin,SFRP2,suramin,tauroursodeoxycholic acid CCND2,MAP3K10,PAK2,STK24 IFNB1 tacrolimus chemical drug 3 0.651 2.41E-04 1.95E-02 26s Proteasome,ABCC4,ACHE,AHR,Akt,ANGPT1,Calcineurin protein(s),CASP3,CDK4,CDKN2A,COP1,CTNNB1,DICER1,EIF2AK3,ERK,ERK1/2,ESR2,ETS2,FADD,Gsk3,Hdac,HRAS,HTT,IFNG,IGF1,IL2,IL6,Jnk,JUN,MAP2K1,MAPK1,MAPK8,MMP2,MMP9,MTOR,MYOD1,NFATC2,NFkB (complex),NFKB1,NGEF,NOS1,NR1I2,NR1I3,NR4A1,NRAS,P38 MAPK,p70 S6k,PDPK1,PGF,PPARGC1A,PPP3CA,PPP3R1,S100A9,STAT5B,tacrolimus,TGFB1,TNF,VDR,Vegf ABCA3,ABCA5,ACAA1,ADGRG6,ADRM1,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,ATL2,BBX,BCHE,CALCRL,CALM1 (includes others),CALML3,CD209,CELSR1,CGAS,CHAC1,CLEC10A,CUBN,CYP39A1,DGAT1,EMX2,ETNK1,FAM111A,FGL1,FLNC,GNAO1,H2AC21,HSD3B2,IFI44,KIFC1,KRT8,Lgals6,LRP4,LRP5,MKX,NANOS1,PGK1,PLG,PLIN2,PNLIP,POLI,PTGIR,RAB11A,RRM2,RRP12,SCARF1,SLC5A7,SUSD2,SVEP1,SYT12,TENM3,TNR,TRIM56,TSG101,VPS25 59 (59) 49 CARD8,caspase,CD6,NFkB (complex),TJP1,VEGFC ANGPT1,CASP3,CAV3,CXCL10,CXCL9,F5,FASLG,ICOS,INS,ITPR1,KLRC4-KLRK1/KLRK1,Na+,K+ -ATPase,PPP3CA,PPP3R1,PRNP,SDCBP,TERT PGF growth factor 2 -1.706 2.41E-04 4.50E-03 Akt,AKT1,ERK1/2,Jnk,KDR,MAPK1,MAPK3,NFATC2,P38 MAPK,PGF,Ras homolog AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BBX,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,FLNC,HNRNPM,IFI44,ITGB3,L1CAM,MATR3,NANOS1,PLG,RRM2,TNFSF14 22 (11) 11 arecoline,EPAS1,PD173074,phytohemagglutinin,prostaglandin E2 mir-182,miR-182-5p (and other miRNAs w/seed UUGGCAA),WNT5A AKT1,ATF3,E2F2,KIT VRK2 kinase 3 0.882 2.46E-04 3.22E-02 26s Proteasome,AKT1,Ap1,APP,AR,BHLHE40,CDKN1B,CDKN2A,CEBPA,CREB1,EGFR,ERK,ERK1/2,ETS2,FOS,GLI1,HIF1A,IL10,IL6,IRF3,ITGB1,Jnk,MAPK8,MAVS,MITF,NFATC2,NR1I3,PLK1,PPARA,PPIF,PRKCE,RB1,RICTOR,RXRA,SIRT1,SNCA,STING1,STK11,TNF,TP53,TWIST1,VRK2 ADGRG6,ADRM1,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,B4GALT1,BBX,BIRC2,BIRC3,C1QTNF3,CALCRL,CALM1 (includes others),CASP2,CD209,CEBPD,CELSR1,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,CSMD3,Cyp2d22,CYP39A1,DGAT1,DUT,FAM111A,FASN,FAT4,FGL1,GLB1,HCRTR2,HNRNPM,ITGB3,KIFC1,MAPK4,MATR3,MEGF11,MGAT4C,MKX,MMRN1,NUBP1,PIF1,PLG,POU3F3,PPP1CA,PTPRK,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,THSD4,TMPRSS6,TNR,TNXB,TPPP3,TRIM3,TRIM56,TSG101 63 (42) 40 3',4',7-trihydroxyisoflavone chemical - endogenous non-mammalian 3 0.832 2.46E-04 1.28E-02 26s Proteasome,3',4',7-trihydroxyisoflavone,Akt,AKT1,Ap1,APP,c-Src,CDK2,CDK4,CDKN1B,CDKN2A,CXCL8,DLX5,E2F3,ESR1,ETS2,FOS,GLI1,GSK3B,HMOX1,HNF4A,IGF1,IL10,IL2,INSR,IRF3,KLF6,LGALS3,MITF,NFATC2,NGEF,NR1I2,NRAS,PDPK1,PI3K (complex),PPARGC1A,RB1,REL,SMARCA4,SOX2,SPARC,TNFSF11,TWIST1 ADRM1,AGA,AIMP2,AKNA,ANGPT2,ANGPTL3,ANOS1,ATL2,BBX,C1QL1,C1QTNF3,CALCRL,CALM1 (includes others),CEBPD,CELSR1,CGAS,CLPB,CR1,CYP39A1,EMILIN2,FAM111A,FASN,FAT4,FCGBP,FRRS1,FUT6,H2BC21,HNRNPM,L1CAM,LRP4,MAPK4,MATR3,MKX,NUBP1,PIF1,PLG,POU3F3,PRKCSH,PTGIR,RAB11A,RRM2,SCARF1,SNAP25,SVEP1,TNFSF14,TNR,TPPP3,TRIM2,TRIM36,TRPM2,TULP4,VPS25 52 (43) 38 ESR2 AKT1,CCNE1 Glycine Receptor complex 3 -1.461 2.47E-04 8.00E-03 Akt,Calcineurin protein(s),CaMKII,Creb,CREB1,DUSP1,ERK,ERK1/2,Glycine Receptor,GRIN3A,L-glutamic acid,MAPK1,MAPK14,Nfat (family),NMDA Receptor,NRAS,NTRK2,P38 MAPK,Pkc(s),RPS6,SRC ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CALCRL,CEBPD,CLEC10A,DPY19L3,FLNC,HCRTR2,IFI44,ITGB3,KRT8,L1CAM,LITAF,LRP6,MGAT4C,PGK1,PLG,PLIN2,PTPRK,SERINC2,SNAP25,TNFSF14,TSG101,TULP4,VPS25 30 (21) 18 NMDA Receptor cerivastatin chemical drug 3 1.723 2.49E-04 2.39E-02 ABCB4,ACE,ACHE,AGT,AHR,Akt,Ap1,APP,CASP8,CDKN1B,cerivastatin,clopidogrel,COP1,CREB1,CTNNB1,CYP19A1,doxorubicin,EGFR,EIF4E,EPAS1,ERK,ERK1/2,ESR2,ETS2,FADD,FOS,Hdac,HIF1A,HMGCR,IGF1,IL2,IL6,IRF3,ITGB1,Jnk,Mapk,MAPT,MITF,MYB,MYC,MYCN,NEDD9,NFATC2,NFkB (complex),NFKB1,NFKB2,NGEF,NOS3,NR1I3,ODC1,P38 MAPK,PDPK1,PGR,PON1,PPARA,PPARG,progesterone,PTK2,RAF1,RAS,RB1,REL,RELA,RICTOR,S100A9,TNF,TWIST1 ACAA1,ADGRG6,AGA,AIMP2,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,ASPG,ATL2,BBX,BCHE,BIRC2,BIRC3,C1QTNF3,CALM1 (includes others),CD209,CEBPD,CGAS,CHAC1,CLEC10A,CLPB,CYP39A1,DGAT1,ETNK1,FAM111A,FAT4,FGL1,GNAO1,IFI44,ITGB3,KMT5A,L1CAM,LRP4,MAPK4,MEGF10,MGAT4C,MKX,NANOS1,NLGN2,NUBP1,PIF1,PLG,PLIN2,PNLIP,PTGIR,RAB11A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A7,SLC5A7,SNAP25,SSPOP,SUSD2,SYT12,THSD4,TMPRSS6,TNFSF14,TNR,TNXB,TPPP3,TRIM56 66 (67) 58 CYP2B6,HMOX1,PPARA,TSC22D3 NFkB (complex),PGR CRBN enzyme -0.000 2 -0.229 2.53E-04 3.40E-03 Ap1,APP,CRBN,ERK1/2,Gsk3,MAPT,P38 MAPK,PRKAA,PRKAA1 ANGPT2,ANK1,AOC1,ASPG,BIRC2,CALM1 (includes others),CEBPD,FASN,GSTM3,H2BC21,HSD3B2,IFI44,ITGB3,LITAF,LRP6,POU3F3,RRM2,THSD4,TPPP3 19 (9) 8 fatty acid ERN1,PRKAA1 PD 169316 chemical drug 3 1.131 2.53E-04 1.12E-02 ACHE,Akt,APP,BCL2,CASP3,CASP8,CDKN1B,CDKN2A,CEBPA,DICER1,DLX5,ESR2,FADD,FOS,HMOX1,HNF1A,HNF4A,HRAS,IFNAR1,IGF1,IL10,IL1B,Jnk,JUN,KRT8,MAPK14,MITF,MYB,MYOD1,NFATC2,NGEF,NRAS,P38 MAPK,p70 S6k,PD 169316,PGR,PI3K (complex),PPARA,REL,RHOA,RICTOR,Rsk,RXRA,S100A9,SIRT1,SLC6A4,SPP1,TGFBR1,TNF AGA,AIMP2,ANGPTL3,ANK1,ATL2,BBX,BCHE,BIRC2,BIRC3,CD209,CGAS,CLEC10A,CLPB,CR1,CYP39A1,ETNK1,FAM111A,FGL1,FUT6,GNAO1,GSTM3,HCRTR2,ITGB3,L1CAM,Lgals6,LRP5,LRP6,MMRN1,NUBP1,PIF1,PKD1L2,POLI,POU3F3,PTPRK,REG1A,RRM2,RRP12,RSL24D1,SCARF1,SLC5A7,SNAP25,TENM3,THSD4,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM56,TULP4,VPS25 50 (49) 43 CCND2,IRS1 CASP3,caspase phosphatase group 2 Activated 2.183 2.54E-04 1.40E-03 AKT1,BCL2,Jnk,P38 MAPK,phosphatase,RB1 ANGPT2,ANK1,BIRC3,CALCRL,CD209,CEBPD,CELSR1,CLEC10A,FASN,H2BC21,HNRNPM,ITGB3,MAPK4,MATR3,PLG,RRM2,SNAP25 17 (6) 5 8-bromo-cAMP AKT1,RPS6KB1 diosgenin chemical - endogenous non-mammalian 3 0.750 2.59E-04 2.83E-02 ACE,aflatoxin B1,AGT,Ap1,APP,AR,CCNH,CEBPA,CFLAR,Ck2,Creb,CREB1,CTCF,CXCL8,CYP19A1,CYP3A4,diosgenin,ESR1,F3,F5,FADD,FGF2,FOS,HIF1A,HNF4A,IGF1,IL1B,IL2,IRF2,IRF3,MAPK8,MAPT,MDM2,mir-21,MMP2,MYB,MYC,MYCN,MYOD1,NCOA4,NFATC2,NFkB (complex),NFKB1,NFKBIA,PGR,RICTOR,RXRA,SIRT1,SMARCA4,SNCA,Sod,SPP1,STAT3,TCF7L2,TNF ALDH7A1,ANGPT2,ANGPTL3,ANOS1,ASPG,ATL2,B4GALT1,BBX,BIRC2,BIRC3,C1QL1,CALM1 (includes others),CD209,CEBPD,CGAS,CHAC1,CLPB,CR1,Cyp2d22,CYP39A1,DGAT1,DPY19L3,ETNK1,FAM111A,FASN,FUT6,GNAO1,GSTM3,H2BC21,HCRTR2,ITGB3,KMT5A,L1CAM,Lgals6,LGMN,LRP5,MEGF10,MEGF11,MGAT4C,MKX,MMRN1,NCAN,NUBP1,PLG,POU3F3,PTGIR,REG1A,RRM2,RSL24D1,SERINC2,SLC16A4,SLC16A7,SSPOP,SVEP1,THSD4,TMPRSS6,TNR,TPPP3,TRAF3IP2,TRIM3,TRIM36,TRIM56,TRPM2,TULP4 64 (55) 48 leukotriene B4 MDM2 TAP1 transporter -0.000 3 0.000 2.62E-04 2.85E-02 Akt,AKT1,Ap1,BCL2,CHUK,CREB1,CTNNB1,EGFR,ERK,HIPK2,IKBKB,IKK (complex),IRF3,JINK1/2,Jnk,JUN,MAP3K7,MAPK1,MAPK14,MAPK3,MAPK8,Mek,NFkB (complex),NFKB1,NFKB2,NFKBIA,P38 MAPK,PRKAA1,PTGS2,REL,SREBF1,SREBF2,STAT3,TAP1 ACAA1,ADGRG6,AGA,AIMP2,ALDH7A1,ANGPT2,ANK1,ANOS1,B4GALT1,BIRC2,C1QTNF3,CALM1 (includes others),CASP2,CD209,CEBPD,CLEC10A,DGAT1,DPY19L3,DUT,FLNC,GLB1,GNAO1,H2BC21,HNRNPM,IFI44,ITGB3,KIFC1,KRT8,LITAF,LRP6,MATR3,MGAT4C,NCAN,PLG,POLI,PTPRK,REG1A,SERINC2,SNAP25,SOD3,SUSD2,TNFSF14,TNXB,XPO7 44 (34) 32 camptothecin,CNTF,daunorubicin,IL27,NFkB (complex),ZFTA-RELA PIK3CG,RPSA MAP3K7 RGS4 enzyme 2 1.147 2.63E-04 2.10E-03 Akt,Calcineurin protein(s),ERK,ERK1/2,GPRC6A,Jnk,P38 MAPK,RGS4 ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,L1CAM,MEGF6,PLG,PLIN2,RRM2,SSPOP,TNFSF14,TSG101 19 (8) 8 CHRM1,CHRM2,EPAS1,G Protein I,LIF [D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin,G protein beta gamma,lactacystin,NR5A2,PROX1,Rab5 ANXA4,GNAI3,PTAFR ESR2,fatty acid,G protein,PPP3R1 oleic acid chemical - endogenous mammalian 3 -0.122 2.64E-04 2.66E-02 26s Proteasome,ABCB4,ACHE,Akt,AKT1,AR,BHLHE40,CASP3,CD36,CDKN2A,CITED2,clopidogrel,Creb,DICER1,doxorubicin,EIF2AK3,ERK1/2,ESR2,ETS2,FADD,Focal adhesion kinase,FOS,Gsk3,HIF1A,HIPK2,HRAS,IFNAR1,IGF1,IL6,Jnk,LPIN1,MAFB,MAPK1,MGAT1,MMP9,MYB,NFATC2,NFkB (complex),NFKBIA,NGEF,NOS3,oleic acid,P38 MAPK,PAWR,PDPK1,PLD2,PON1,PPARA,PRKAA,PRKAA1,RICTOR,S100A9,SNCA,SOX2,SPARC,SRC (family),STAT3,STAT4,STING1,TGFB1,TNFSF11,TP53,TXNIP ACAA1,ADRM1,AIMP2,ALDH7A1,ANK1,AOC1,ATL2,B4GALT1,BBX,BCHE,C1QL1,CALCRL,CALML3,CASP2,CD209,CELSR1,CGAS,CLEC10A,CSMD3,Cyp2d22,DGAT1,DPY19L3,DUT,ETNK1,FAM111A,FASN,FGL1,FLNC,FRRS1,GLB1,GSTM3,H2BC21,HNRNPM,HSD3B2,ITGB3,KIFC1,KMT5A,KRT8,LRP4,LRP5,MATR3,MEGF11,MKX,NANOS1,NCAN,NUBP1,PGK1,PLIN2,PNLIP,PPP1CA,PTGIR,PTPRK,RAB11A,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC5A7,TENM3,TMPRSS6,TNFSF14,TRIM2,TRIM3,TSG101,TULP4,XPO7 67 (63) 56 PPARD quercetin AKT1,anandamide,ANGPTL4,Ca2+,CASP3,CDKN2A,CX3CL1,fatty acid,FFAR1,Focal adhesion kinase,JINK1/2,LHB,p85 (pik3r),PPARA,RXRA ceramide,HMOX1,IRS1,leukotriene B4,LPIN1,Na+,K+ -ATPase,NFkB (complex),NPY,phospholipid,PIK3IP1,PRKAA1,SPHK1 TSC22D3 transcription regulator 3 0.485 2.65E-04 2.12E-02 AHR,Akt,AKT1,Ap1,APP,ATF4,CDKN1B,CFTR,COP1,CREB1,CTNNB1,CXCL8,EIF4E,ERK,ERK1/2,ESR1,ETS2,FADD,FOS,FOXO1,FOXO3,Hdac,HIF1A,HNF4A,HRAS,IGF1,IL10,IL2,IL6,Jnk,MAP2K1/2,MAPK1,MAPK3,Mek,MITF,MLXIPL,NEDD4L,NFkB (complex),NFKB1,NFKB2,NGEF,NRAS,P38 MAPK,PPARA,PPARGC1A,PRKCA,RAF1,RAS,RB1,REL,RELA,RICTOR,S100A9,SGK1,SOX2,SPARC,STK11,TCF7L2,TGFB1,TNF,TNFSF11,TSC22D3,TSG101 ADGRG6,AGA,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,ATL2,BCHE,BIRC2,C1QL1,C1QTNF3,CALCRL,CALM1 (includes others),CALML3,CD209,CEBPD,CELSR1,CGAS,CHAC1,CLEC10A,CLPB,CR1,CUBN,ETNK1,FGL1,FLNC,FRRS1,FUT6,GNAO1,H2BC21,HNRNPM,IFI44,ITGB3,KMT5A,L1CAM,LRP4,MAPK4,MATR3,MGAT4C,MKX,NLGN2,NUBP1,PIF1,PLG,PTGIR,PTPRK,RAB11A,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SOD3,SUSD2,SVEP1,SYT12,TENM3,THSD4,TKFC,TMPRSS6,TNFSF14,TPPP3,TRIM2,TRIM56,TRPM2,VPS25 68 (63) 55 3-deazaneplanocin,cerivastatin,IgG,nelfinavir,PGR,prednisolone CASP3 AKT1,FASLG,NFkB (complex),SALL4 PKN2 kinase 3 -0.640 2.66E-04 3.21E-02 AKT1,APP,AR,BHLHE40,CD28,CDKN1B,CDKN2A,CEBPA,CTNNB1,EIF4E,ELAVL1,ESR2,ETS2,FOS,FYN,HNF4A,HRAS,IL6,IRF3,Jnk,PAWR,PKN2,PPIF,PRKCD,PRKCE,PRKCZ,REL,RICTOR,SNCA,SOX2,SPARC,STING1,TCF7L2,TNF,TNFSF11,TP53,TWIST1,VDR ACAA1,AGA,ANK1,ANOS1,BIRC2,C1QL1,CACHD1,CALCRL,CASP2,CD209,CEBPD,CELSR1,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CSMD3,CUBN,Cyp2d22,DUT,EMX2,FAM111A,FAT4,FCGBP,FGL1,FRRS1,FUT6,GLB1,HNRNPM,HSD3B2,KIFC1,KMT5A,L1CAM,LRP4,MATR3,MEGF11,MKX,MMRN1,NLGN2,NUBP1,PGK1,PIF1,PLG,PLIN2,POU3F3,PPP1CA,RRM2,RRP12,RSL24D1,SCARF1,SLC5A7,SOD3,SUSD2,TENM3,THSD4,TPPP3,TRIM2,TRIM3,TRIM56,TSG101 61 (38) 36 ciprofloxacin,PDK1,phospholipid ganglioside GT1 chemical - endogenous mammalian 3 0.882 2.66E-04 2.13E-02 Akt,AKT1,Ap1,AR,BAD,CD38,CEBPA,COP1,CREB1,CTNNB1,DIO3,DLX5,EIF4E,ERK1/2,ETS2,FGF2,FGFR2,FOS,ganglioside GT1,HIF1A,HMOX1,HNF1A,HRAS,IGF1,IL10,ILK,INSR,IRAK1,ITGB1,MITF,MYB,MYC,NEDD9,NGEF,NR1I3,P38 MAPK,PGR,PPARA,PPARGC1A,RAF1,RICTOR,S100A9,SIRT1,SNCA,SOX2,SPARC,TNFSF11,TWIST1,Vegf,ZC3H12A ADAMTS16,AIMP2,ANGPT2,ANGPTL3,ANK1,AOC1,ATL2,BCHE,BIRC2,BIRC3,C1QL1,CALM1 (includes others),CEBPD,CHAC1,CR1,CUBN,Cyp2d22,CYP39A1,EMILIN2,FAM111A,FASN,FAT4,FCGBP,FGL1,FRRS1,FUT6,GSTM3,HCRTR2,HNRNPM,L1CAM,LRP4,LRP5,MATR3,MEGF11,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PGK1,PIF1,PKD1L2,PLG,POU3F3,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A7,SUSD2,SVEP1,SYCE2,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TNXB,TPPP3,TRIM2,TRIM3,TULP4 63 (50) 45 CASP3 AKT1 DAB2 other 2 -0.209 2.67E-04 5.10E-03 Akt,Ap1,DAB2,ERK,ERK1/2,Focal adhesion kinase,GATA4,JINK1/2,Jnk,LRP5,MAPK1,MYO6,NOS3,P38 MAPK,SRC ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,CALM1 (includes others),CD209,CLEC10A,EMX2,FASN,FLNC,HSD3B2,IFI44,KRT8,L1CAM,LRP6,NLGN2,PGK1,PLG,PTPRK,RRM2,SOD3,TNFSF14 23 (15) 14 ESR2,PDGFRA,SYVN1 PRNP,WNT5A Focal adhesion kinase,JINK1/2,LRP5 CISH other 3 0.000 2.67E-04 2.57E-02 AHR,APP,CISH,CITED2,CREB1,CTNNB1,CXCL8,ESR2,ETS2,FADD,FOXA2,HOXA10,HRAS,IFNG,IFNGR1,IL10RA,IL1B,IL2RB,IL4,IL6,IL6ST,IRF3,JAK,JAK1,JAK2,Jnk,MAPK1,MAPT,MYB,Nfat (family),NFATC2,NFkB (complex),NFKB2,NR1I2,PPARA,RB1,REL,RICTOR,RXRA,SIRT1,STAT,STAT1,STAT3,STAT5A,STAT5B,STAT6,TNF,TWIST1 AGA,ALDH7A1,ANGPT2,ANGPTL3,ANOS1,ARL6IP4,ASPG,B4GALT1,BBX,BCHE,C1QTNF3,CACHD1,CEBPD,CHAC1,CLEC10A,CR1,CYP39A1,EMILIN2,ETNK1,FCGBP,FGL1,FLNC,GLB1,GSTM3,H2AC21,HCRTR2,HSD3B2,IFI44,ITGB3,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,PGK1,PLG,POU3F3,PTPRK,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC5A7,SOD3,SUSD2,SYT12,TENM3,THSD4,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM56,TULP4,XPO7 56 (48) 44 AKT1,CNTF,IL31,LIF,Stat5b dimer CASR DNAJC5,TGFBI CA4,CCL3L3,CXCL10,DUSP2,HMOX1,leukotriene B4,NFkB (complex),PPP1R15A,SPHK1 prostaglandin A2 chemical - endogenous non-mammalian 2 -0.200 2.70E-04 5.60E-03 ERK,Jnk,NFkB (complex),P38 MAPK,PPARA,PPARD,PPARG,prostaglandin A2,RB1 ACAA1,ADGRG6,ALDH7A1,ANGPT2,ANGPTL3,ANK1,B4GALT1,BIRC2,CALCRL,CD209,CELSR1,CLEC10A,CYP39A1,DGAT1,FASN,FCGBP,GSTM3,H2BC21,ITGB3,MAPK4,PLG,PLIN2,RRM2,SERINC2,SOD3 25 (9) 8 CASP3,HMOX1,PPARA,PPARD NFkB (complex) Z36 chemical reagent 2 Inhibited -2.121 2.74E-04 1.60E-03 EIF2AK3,ERN1,Z36 BIRC2,BIRC3,CEBPD,CHAC1,DGAT1,FASN,PLIN2,PNLIP 8 (3) 3 ERN1,HMOX1,PPP1R15A,RETREG1 SENP2 peptidase 2 -0.853 2.77E-04 4.40E-03 Akt,APC,CTNNB1,DDX58,MAPK8,MDM2,NFkB (complex),SENP2 ACAA1,AIMP2,ALDH7A1,BIRC2,CASP2,CEBPD,DGAT1,EMX2,H2BC21,IFI44,ITGB3,KIFC1,L1CAM,PGK1,PLG,PLIN2,RRM2,SOD3,SUSD2,TNFSF14,TSG101,WRN 22 (8) 8 etoposide,forskolin MSTN acetylcholine,MDM2,PDK1,SLC2A1 UBB enzyme -0.000 3 0.272 2.78E-04 2.71E-02 26s Proteasome,AKT1,APP,CDKN2A,CEBPB,COP1,Creb,CREB1,CTNNB1,EGFR,EIF4E,ERK1/2,ESR1,FADD,FOS,HIF1A,HIPK2,HNF4A,IRF3,Jnk,JUN,KRT8,MAP2K4,MAP3K7,MAPK1,MAPT,NCAM1,NFKB2,NFKBIA,RB1,REL,RICTOR,RXRA,SNCA,SREBF1,SREBF2,TGFB1,TNF,TRAF2,TWIST1,UBB,UCHL1,XPC ADRM1,AGA,ANGPTL3,ANOS1,AOC1,ASPG,BIRC2,C1QTNF3,CALML3,CASP2,CD209,CEBPD,CGAS,CHAC1,CLEC10A,DPY19L3,ETNK1,FAM111A,FAT4,FCGBP,FLNC,FUT6,GSTM3,HNRNPM,IFI44,KRT8,LITAF,MAPK4,MATR3,MEGF11,MGAT4C,NCAN,NLGN2,NUBP1,PLG,POLI,POU3F3,REG1A,RSL24D1,SERINC2,SLC16A4,SOD3,SUSD2,SYT12,THSD4,TMPRSS6,TNR,TNXB,TPPP3,TRIM2,TRIM3,TRIM56,TRPM2,XPO7 54 (43) 41 MAP3K7,XPC ANAPC11 enzyme 3 Activated 2.357 2.79E-04 4.60E-03 Akt,ANAPC11,BCL2L1,CCNB1,CDK2,CDKN1B,FGF2,MAPT,PBK,PI3K (family),PTTG1,RB1 AIMP2,ANGPT2,ASPG,BIRC2,BIRC3,CEBPD,CLPB,H2BC21,L1CAM,LRP5,LRP6,MAPK4,PGK1,PLG,POLI,SNAP25,TNFSF14,WRN 18 (12) 10 PTTG1 ANAPC2 other -0.000 3 Activated 2.357 2.79E-04 4.60E-03 Akt,ANAPC2,BCL2L1,CCNB1,CDK2,CDKN1B,FGF2,MAPT,PBK,PI3K (family),PTTG1,RB1 AIMP2,ANGPT2,ASPG,BIRC2,BIRC3,CEBPD,CLPB,H2BC21,L1CAM,LRP5,LRP6,MAPK4,PGK1,PLG,POLI,SNAP25,TNFSF14,WRN 18 (12) 10 PTTG1 UBE2C enzyme 0.000 3 Activated 2.357 2.79E-04 4.60E-03 Akt,BCL2L1,CCNB1,CDK2,CDKN1B,FGF2,MAPT,PBK,PI3K (family),PTTG1,RB1,UBE2C AIMP2,ANGPT2,ASPG,BIRC2,BIRC3,CEBPD,CLPB,H2BC21,L1CAM,LRP5,LRP6,MAPK4,PGK1,PLG,POLI,SNAP25,TNFSF14,WRN 18 (12) 10 Irgm1,l-asparaginase,MFAP5 PTTG1 L-triiodothyronine chemical - endogenous mammalian 2 -0.949 2.80E-04 1.49E-02 ACHE,Akt,AKT1,CDK2,CFTR,CREB1,CTNNB1,CYP19A1,DIO2,DIO3,ERK,ERK1/2,Jnk,L-triiodothyronine,MAP3K7,NFkB (complex),NFKBIA,PLA2G2A,RB1,SMAD3,STAT3 ACAA1,ADAMTS16,ADGRG6,AIMP2,ALDH7A1,ANGPTL3,AOC1,ASPG,B4GALT1,CALCRL,CD209,CELSR1,CLEC10A,CUBN,DGAT1,EMX2,FASN,H2BC21,HNRNPM,IFI44,ITGB3,KIFC1,KRT8,L1CAM,MAPK4,MATR3,MGAT4C,NCAN,PGK1,PLIN2,PTPRK,SERINC2,SLC16A4,SLC5A7,SNAP25,SSPOP,SUSD2,SYCE2,SYT12,TNFSF14 40 (21) 21 SLC5A5 carbon tetrachloride,iopanoic acid,LG100268,tunicamycin ACHE,ACSL1,AKT1,CCNE1,DAB2IP,DBP,ENG,EPAS1,ESR2,fatty acid,FZD8,INHA,ITPR1,MAP3K7,Na+,K+ -ATPase,NR5A2,p85 (pik3r),PGR,POR,POU5F1,PTAFR,RASGRP1,RBP1,RGS16,RPS6KA4,RPS6KB1,SEMA7A,SFRP2,SLC2A1 ADAM10,BTG2,CASP3,CDKN2A,CYP27B1,DVL1,EHHADH,FASLG,Frizzled,IGFBP6,INS,miR-133a-3p (and other miRNAs w/seed UUGGUCC),NFkB (complex),NR0B1,NTRK1,PTTG1,RELN,SCD,UBA1,urea IFNB1 cytokine 3 0.000 2.84E-04 3.38E-02 AHR,Akt,AKT1,APP,ATM,CASP3,CASP8,CDKN1B,CDKN2A,CHEK2,CITED2,COP1,Creb,DICER1,DLX5,E2F3,EIF2AK3,EIF4E,ETS2,FMR1,FOS,GLI1,GSK3B,Hdac,HIPK2,HNF1A,HNF4A,HRAS,IFNAR1,IFNB1,IFNG,IFNGR1,IGF1,IL1B,IRF3,JAK1,KLF6,LGALS3,MAPK1,MAPK14,mir-21,MKNK1,MMP9,MYOD1,NFATC2,NFkB (complex),NFKB2,NRAS,P38 MAPK,p70 S6k,PPARGC1A,PRKCE,RAC1,RAF1,RAS,RB1,REL,RELA,RICTOR,RPS6KB1,S100A9,SIRT1,SMARCA4,SOX2,SPARC,STAT1,STAT3,STAT4,TCF7L2,TNF,TNFSF11,TP53 ADRM1,AGA,AIMP2,AKNA,ALDH7A1,ANK1,ANOS1,ARL6IP4,ATL2,BBX,BCHE,C1QL1,C1QTNF3,CALCRL,CASP2,CD209,CELSR1,CGAS,CHRNB3,CLPB,CSMD3,Cyp2d22,DPY19L3,DUT,FAM111A,FLNC,FRRS1,FUT6,GLB1,GNAO1,H2AC21,H2BC21,HCRTR2,HNRNPM,ITGB3,KIFC1,KMT5A,L1CAM,Lgals6,LRP4,LRP5,LRP6,MAPK4,MATR3,MKX,NLGN2,NUBP1,PGK1,PKD1L2,PNLIP,POU3F3,PPP1CA,PRKCSH,PTPRK,RSL24D1,SLC16A7,SNAP25,SOD3,SVEP1,SYCE2,SYT12,TENM3,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM2,TRIM36,TRIM56,TSG101,VPS25,XPO7 72 (72) 61 1,1-diethyl-2-hydroxy-2-nitrosohydrazine,3-deazaneplanocin,ATF2,CAMP,chenodeoxycholic acid,CRKL,DDX41,EBF1,etoposide,IgG,irinotecan,LRRFIP1,Map3k7,MAPK7,Pam3-Cys,peptidoglycan,PHLPP1,PPP1R15A,PRKAA1,RNF41,RPS6KB2,S100A9,TERT,tunicamycin,USP27X,WNT5A 3-methyladenine,4-(2-aminoethyl)benzenesulfonylfluoride,8-bromo-cAMP,camptothecin,caspase,CLEC4C,dorsomorphin,forskolin,HMOX1,IRAK3,MAP3K8,MERTK,miR-182-5p (and other miRNAs w/seed UUGGCAA),NLRX1,prednisolone,PROS1,prostaglandin E2,quercetin,RABGEF1,RPS6KA4,SOCS6,TIRAP,TNFAIP8L2,TRAF1,XAV939 BHLHE40,CCL7,CXCL10,IL27,miR-34a-5p (and other miRNAs w/seed GGCAGUG),NMI KLRC4-KLRK1/KLRK1 PRNP other 2 -0.962 2.87E-04 7.30E-03 26s Proteasome,AKT1,ATM,CTNNB1,ERK1/2,MAPK1,MAPK3,MAPK8,MAPK9,NFkB (complex),P38 MAPK,PDPK1,Pkc(s),PRNP ACAA1,ADRM1,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,DGAT1,EMX2,FLNC,HNRNPM,IFI44,ITGB3,KIFC1,KRT8,L1CAM,MATR3,PGK1,PLG,PTPRK,RAB11A,RRM2,SNAP25,SUSD2 27 (14) 14 tunicamycin beta-cyclodextrin,prednisolone,roscovitine,tacrolimus AKT1,Ca2+,CASP3,caspase,CDKN2A,FGF9,NFkB (complex),NTRK1,prostaglandin E2 DAB2,IRS1,MDM2 PAK3 kinase 3 Inhibited -2.216 2.90E-04 3.11E-02 Ap1,APP,AR,Calcineurin protein(s),CDKN1B,CEBPA,COP1,Creb,CREB1,CTNNB1,CYP19A1,EIF2AK3,ERBB2,ESR1,ESR2,FADD,FOS,HIF1A,HNF1A,HNF4A,HRAS,IFNAR1,IGF1,IRF3,Jnk,KRT8,LEP,MAP2K1,MAP3K1,MAPK10,MAPK11,MAPK12,MAPK13,MAPK14,MAPK8,MAPK9,MAPT,MITF,MYB,MYO6,MYOD1,NFATC2,P38 MAPK,PAK3,PGR,PPARA,PPARGC1A,RAF1,RB1,RICTOR,RXRA,S100A9,SIRT1,SPP1,STAT4,STK11,TGFB1,TNF,TP53,TWIST1 ANGPTL3,ANK1,ANOS1,ASPG,ATL2,B4GALT1,BBX,BCHE,BIRC2,BIRC3,CALM1 (includes others),CALML3,CD209,CEBPD,CGAS,CLEC10A,CLPB,CSMD3,Cyp2d22,CYP39A1,DGAT1,DPY19L3,EMILIN2,ETNK1,FAT4,FGL1,FUT6,GSTM3,H2BC21,HCRTR2,ITGB3,KIFC1,Lgals6,LRP6,MGAT4C,MMRN1,NLGN2,NUBP1,PIF1,PKD1L2,PLG,PLIN2,PNLIP,POU3F3,PPP1CA,REG1A,RRM2,RRP12,RSL24D1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SOD3,SUSD2,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNR,TPPP3,TRIM56,TRPM2,TSG101,TULP4 66 (60) 55 FRAX-597 Hsp90 group 2 0.729 2.90E-04 3.26E-02 AHR,Akt,CD24,ERBB2,ERK,ERK1/2,ESR2,estrogen receptor,geldanamycin,HSF1,Hsp90,Jnk,KDM3A,MAPT,Nfat (family),NOS3,NR1I2,P38 MAPK,PGR,PPARA,RAF1,SMAD3,STAT1,STAT3,STK11,TP53 ACAA1,ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,ASPG,B4GALT1,CALCRL,CASP2,CD209,CLEC10A,CSMD3,CYP39A1,DGAT1,DPY19L3,EMILIN2,FLNC,GLB1,GNAO1,GSTM3,HSD3B2,ITGB3,KIFC1,L1CAM,MAPK4,MEGF10,PGK1,PLG,PLIN2,POLI,PPP1CA,PTPRK,RRP12,SERINC2,SLC16A4,SLC16A7,SLC5A7,SNAP25,SNX33,SOD3,SYT12,TNFSF14,TNXB,TRIM2,TRIM3,TSG101 47 (26) 25 benzo(a)pyrene,carmustine,hydrogen sulfide,lactacystin,prostaglandin A1,riluzole caffeic acid phenethyl ester,quercetin,retaspimycin,S-adenosylmethionine,tanespimycin AKT1,CCND2,EIF2AK1,EPAS1,ESR2,FGFR3,Focal adhesion kinase,KDM3A,KIR2DS2 (includes others),MAP3K7 ATR,PGR,PPARA,radical levothyroxine chemical - endogenous mammalian 2 -1.569 2.91E-04 4.70E-03 Akt,AKT1,CFTR,DIO2,DIO3,ERK,ERK1/2,GRIN3A,ITGB3,levothyroxine,MIF,PNPT1,STAT1,THRB ACAA1,ADAMTS16,ADGRG6,AIMP2,ANGPT2,ANGPTL3,AOC1,BIRC2,BIRC3,CASP2,CEBPD,CUBN,DGAT1,FASN,HCRTR2,HNRNPM,IFI44,ITGB3,L1CAM,MATR3,PLG,RRM2,SERINC2,SLC16A4,SYCE2,TNFSF14 26 (14) 14 CCR7,thyroid hormone carbon tetrachloride,LG100268,NPY,PRCP PENK,SFRP2,SSTR5 CDKN2A,GSTA1,IGFBP6,LHB RAPGEF3 other 3 -0.882 2.92E-04 2.50E-02 ACHE,Akt,AMPK,APP,ATF4,CaMK I,CITED2,COP1,Creb,CREB1,CTNNB1,CYP19A1,EIF2AK3,EIF4E,ELAVL1,ERK1/2,ESR1,ESR2,ETS2,FADD,H/K/NRAS,HDAC5,HIF1A,HNF4A,HRAS,IGF1,IL10,INSR,IRF3,Jnk,MAPK1,MAPK3,MAPT,MITF,MLXIPL,MYB,MYOD1,NEDD9,NFATC2,NGEF,NR1I3,NRAS,P38 MAPK,PDPK1,PIK3CG,PLC,PPARGC1A,PRKCE,PTK2,PTK2B,RAC1,RAP1A,RAPGEF3,RB1,RICTOR,RXRA,S100A9,SIRT1,SNCA,STAT3,STAT5B,STK11,TCF7L2,TNF,TWIST1 AIMP2,ANGPTL3,ANK1,ANOS1,AOC1,ASPG,ATL2,B4GALT1,BBX,BCHE,BIRC2,BIRC3,CACHD1,CALCRL,CHAC1,CHRNB3,CLEC10A,CR1,CYP39A1,DPY19L3,EMILIN2,ETNK1,FCGBP,FLNC,FUT6,HCRTR2,IFI44,ITGB3,KMT5A,KRT8,L1CAM,Lgals6,MAPK4,MEGF10,MEGF11,MGAT4C,MKX,NLGN2,PGK1,PIF1,PLG,PNLIP,PTPRK,RAB11A,RRP12,RSL24D1,SCARF1,SLC16A4,SLC5A7,SUSD2,SVEP1,SYT12,TENM3,THSD4,TKFC,TMPRSS6,TNFSF14,TNR,TPPP3,TRIM3,TRIM56,TRPM2,VPS25 63 (65) 56 BIIE 0246,forskolin,NTN1 NPY Ca2+,RAP1A,SOCS3 PIK3CG ceramide chemical - endogenous mammalian 3 -0.397 2.95E-04 1.52E-02 AGT,AHR,Akt,AKT1,AMPK,Ap1,CASP1,CASP8,CEBPB,ceramide,COP1,CYP19A1,doxorubicin,EGFR,ERK,ERK1/2,FADD,FAS,Gsk3,GSK3B,Hdac,HIPK2,HNF1A,HRAS,IFNG,IGF1,IL1,IL1B,IL2,Jnk,LGALS3,MAFB,MAP3K7,MAPK14,MAPK8,MLXIPL,MYOD1,Nfat (family),NFkB (complex),NFKB2,NGEF,NOS3,NUPR1,P38 MAPK,PDPK1,PI3K (complex),Pkc(s),PP2A,PRKCZ,PRKRA,RAF1,RB1,RELA,RICTOR,S100A8,S100A9,SET,SOX2,SPARC,SREBF1,TGFB1,TNFSF11 ADGRG6,AIMP2,ALDH7A1,AOC1,ASPG,ATL2,BCHE,C1QL1,C1QTNF3,CALCRL,CALM1 (includes others),CALML3,CASP2,CD209,CELSR1,CLEC10A,DGAT1,DPY19L3,DUT,ETNK1,FAM111A,FRRS1,GLB1,H2AC21,H2BC21,HNRNPM,IFI44,ITGB3,KIFC1,KMT5A,KRT8,L1CAM,Lgals6,LGMN,LRP4,LRP6,MAPK4,MATR3,PKD1L2,PLIN2,PRKCSH,PTGIR,RAB11A,REG1A,RSL24D1,SCARF1,SLC16A7,SOD3,SSPOP,SYT12,TENM3,TKFC,TNFSF14,TNXB,TRAF3IP2,TRIM2,XPO7 57 (62) 52 camptothecin,cerebroside 3-sulfate,daunorubicin,deguelin,deoxycholate,dorsomorphin,EPAS1,FASLG,fatty acid,forskolin,perifosine,SCD,sphingomyelin amitriptyline,Ca2+,fumonisin B1,infliximab,KIT,oleic acid,SPHK1,zoledronic acid CASP3,caspase,GSTA1,KSR1,MAP3K11,MAP3K7,NFkB (complex),prostaglandin E2,Sapk,SFRP1 SLC5A5 GAST other 3 -1.732 2.96E-04 2.62E-02 26s Proteasome,AGT,Akt,AKT1,Alpha catenin,Ap1,APP,ATF2,ATF4,CASP3,CDKN1B,CNR1,Creb,CREB1,CTNNB1,CXCL8,DICER1,EGFR,ELAVL1,ELK1,EPAS1,ERK,ERK1/2,ETS2,FADD,FGFR2,Focal adhesion kinase,FOS,GAST,Gpcr,HIF1A,HNF1A,HNF4A,HOXA10,HRAS,IFNGR1,IGF1,IL10,IL2,IRF3,JAK2,Jnk,JUN,Mapk,MAPK1,MAPK14,MAPK3,MAPK7,MAPK8,mir-21,MITF,MYOD1,NGEF,NRAS,P38 MAPK,PI3K (complex),PKD1,PPARG,PPP3R1,PRKCA,PRKCE,progesterone,PTK2,RAF1,REL,RELA,RICTOR,RXFP2,S100A9,SHC1,SNCA,SOX2,SP1,SPARC,SRC,SST,STAT3,STK11,TCF7L2,TNF,TNFSF11,TSH,VitaminD3-VDR-RXR,WBP2,WWOX ABCA5,ADGRG6,ADRM1,AGA,AIMP2,ANGPT2,ANK1,ANOS1,AOC1,ARL6IP4,ATL2,B4GALT1,BCHE,BIRC3,C1QL1,C1QTNF3,CACHD1,CALM1 (includes others),CD209,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,DGAT1,DPY19L3,EMX2,ETNK1,FAM111A,FGL1,FLNC,FRRS1,FUT6,HNRNPM,IFI44,ITGB3,KIFC1,KMT5A,KRT8,Lgals6,LITAF,LRP4,LRP5,LRP6,MATR3,MEGF11,MGAT4C,MKX,NUBP1,PGK1,PIF1,PKD1L2,PLG,PLIN2,POLI,PTGIR,PTPRK,REG1A,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SNAP25,SSPOP,SUSD2,TENM3,THSD4,TMPRSS6,TNFSF14,TNXB,TRIM2,TRIM56,VPS25 75 (85) 74 EP300,forskolin AKT1,ATF2,Focal adhesion kinase,HCFC1,iron,LOC102724428/SIK1,MAP3K11,MAPK7,MMP7,POR,PRKD2,PRKD3 CASP3,IL11 KIT transmembrane receptor 3 -1.612 2.96E-04 1.71E-02 26s Proteasome,Akt,AKT1,APP,AR,CDKN1B,CDKN2A,COP1,CREB1,EIF2AK3,EIF4E,ELAVL1,EPAS1,ERK1/2,ETS2,FADD,FOS,FYN,GAB2,GRB2,Hdac,HIF1A,HNF4A,HRAS,IGF1,IL10,JAK,Jnk,KIT,LCK,MAP2K1/2,Mapk,MAPK1,MAPK7,MAPK8,Mek,MITF,MYOD1,NEDD9,NGEF,NRAS,P38 MAPK,p70 S6k,PGR,PI3K (complex),PKD1,PLC gamma,PPARA,PPARGC1A,PPP3R1,PTPN11,RAF1,RAS,REL,RICTOR,RUNX3,SH2B2,Shc,SNCA,Sos,SOX2,SPARC,SRC,STAT,Stat dimer,STAT1,STAT4,STK11,TCF7L2,TNF,TNFSF11,WBP2,WWOX ABCA3,ABCA5,ADRM1,AGA,AIMP2,ANGPT2,ANK1,AOC1,ATL2,BIRC2,BIRC3,C1QL1,CACHD1,CD209,CEBPD,CHAC1,CLEC10A,CLPB,CR1,Cyp2d22,DGAT1,EMILIN2,EMX2,ETNK1,FAM111A,FLNC,FRRS1,FUT6,GSTM3,HNRNPM,IFI44,ITGB3,KIFC1,KMT5A,L1CAM,Lgals6,LRP4,MATR3,MEGF11,MGAT4C,MKX,NLGN2,NUBP1,PGK1,PIF1,PLG,PNLIP,PTPRK,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TPPP3,TRIM2,TRIM3,TRIM56,VPS25 65 (73) 60 8-bromo-cAMP,deferoxamine,INHA,NFkB (complex),PGF,phytohemagglutinin,TFAP2B,tyrosine kinase,WNT3A,WNT5A AKN-028,ATP2B2,BHLHE40,DAB2IP,ESR2,huaier extract granule,mir-154,MIR17HG,NOX4,OSI-930,retaspimycin,tanespimycin,vatalanib AKT1,MAPK7,p85 (pik3r),PLC gamma CCND2,ceramide ajoene chemical - endogenous non-mammalian 3 -1.192 2.97E-04 2.48E-02 ACHE,ajoene,Akt,AMPK,Ap1,APP,CASP3,CDKN1B,CEBPA,CITED2,COP1,CREB1,CYP19A1,DICER1,EGFR,EIF4E,ESR2,ETS2,FOS,HIF1A,HNF4A,HRAS,IGF1,IRF3,MAPK1,MAPK3,MAPK8,MAPK9,MAPT,MITF,MLXIPL,MYB,MYC,NFATC2,NFkB (complex),NFKBIA,NGEF,P38 MAPK,PPARA,PPARGC1A,PRKAA1,PRKCD,RAF1,RICTOR,RXRA,S100A9,SIRT1,SREBF2,STAT4,STK11,Vegf AIMP2,ALDH7A1,ANGPTL3,ANK1,ANOS1,ASPG,ATL2,B4GALT1,BBX,BCHE,BIRC2,BIRC3,CALM1 (includes others),CEBPD,CLPB,Cyp2d22,DGAT1,EMILIN2,FLNC,FUT6,HCRTR2,IFI44,ITGB3,L1CAM,LITAF,LRP5,MEGF10,MGAT4C,MKX,MMRN1,NCAN,NLGN2,NUBP1,PIF1,PLG,PLIN2,PTPRK,REG1A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SOD3,SVEP1,SYT12,TENM3,THSD4,TKFC,TMPRSS6,TNFSF14,TNXB,TPPP3,TULP4 57 (51) 48 CASP3 chondroitin sulfate E chemical - endogenous mammalian 2 0.655 2.99E-04 4.10E-03 chondroitin sulfate E,CTNNB1,ERK1/2,FGFR2,NFkB (complex),SMAD3 ACAA1,ALDH7A1,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,CUBN,DGAT1,EMX2,FASN,ITGB3,KIFC1,L1CAM,PGK1,PLIN2,PTPRK,SOD3,SUSD2,TENM3 21 (6) 5 LRP6,NFkB (complex) farnesol chemical reagent 2 -1.147 3.00E-04 3.50E-03 Akt,CDK2,ERK,ERK1/2,farnesol,Jnk,NR1H4,P38 MAPK,RAS ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,ITGB3,L1CAM,PLG,RRM2,SNAP25,SOD3,TNFSF14 19 (9) 8 ATF3,CASP3,PPARA Dishevelled group 3 0.849 3.01E-04 1.47E-02 Alpha catenin,CAMK2,CEBPA,CTNNB1,Dishevelled,EGLN,EIF2AK3,EIF4E,ELAVL1,ESR1,FADD,FOS,GNE,Gsk3,GSK3B,Hdac,HNF4A,HRAS,IRF3,Jnk,KLF6,KRT8,LGALS3,MAFB,MAPK1,MAPK8,MAPT,MITF,MYB,NRAS,Pkc(s),PLC,PRKCE,Rac,RAC1,Ras homolog,RB1,RICTOR,RXRA,S100A8,S100A9,SIRT1,SLC18A3,TAFAZZIN,TNF,TWIST1,Wnt,WNT5A ACAA1,ADRM1,ANGPTL3,ANOS1,ASPG,B4GALT1,BCHE,BIRC2,C1QTNF3,CACHD1,CD209,CHAC1,CHRNB3,CLEC10A,CSRNP3,DGAT1,EMX2,ETNK1,FAM234B,FAT4,FLNC,FUT6,HCRTR2,KIFC1,KRT8,L1CAM,LRP4,LRP5,MAPK4,MEGF10,MMRN1,NLGN2,NUBP1,PGK1,PIF1,PLG,PLIN2,PNLIP,PRKCSH,PTGIR,REG1A,RSL24D1,SLC5A7,SUSD2,TENM3,TNR,TRIM56,TRPM2,TULP4,VPS25 50 (48) 40 Frizzled,WNT3A CAMK2,PIP5K1B CDX1 transcription regulator 3 1.786 3.01E-04 2.26E-02 26s Proteasome,Ap1,CDK2,CDK4,CDK6,CDKN2A,CDX1,Creb,CREB1,CTNNB1,E2F3,ESR1,HIF1A,HMOX1,HRAS,IL10,IRF3,ITGB1,KLF5,MAPK14,MAPT,MYB,NFKBIA,NR1I2,NRAS,PDPK1,PI3K (complex),PPARGC1A,RB1,REL,RHOA,SALL4,SIRT1,SMARCA4,SOX2,TCF7L2,TSC1,VDR ABCA3,ACAA1,ADRM1,AGA,AKNA,ANGPT2,ANGPTL3,ANOS1,ASPG,BIRC3,C1QL1,CALCRL,CALM1 (includes others),CEBPD,CELSR1,CR1,CUBN,CYP39A1,DPY19L3,EMILIN2,EMX2,FAM111A,FASN,FLNC,H2BC21,HCRTR2,KMT5A,KRT8,L1CAM,LITAF,LRP4,LRP6,MAPK4,MEGF10,MGAT4C,NCAN,PGK1,PLIN2,RAB11A,RRM2,SERINC2,SLC16A4,SNAP25,SUSD2,SVEP1,TENM3,TMPRSS6,TNR,TNXB,TRIM36,TRPM2,TULP4,VPS25 53 (38) 34 NFkB (complex),WNT1 SALL4 ALDH3A1,CCND2,FOXQ1,TFF2 iron chemical - endogenous mammalian 2 -1.606 3.12E-04 2.70E-03 Akt,AMPK,docosahexaenoic acid,EGLN,ERK,ERK1/2,iron,Jnk,MAP3K7,MAPT ADGRG6,AIMP2,ANGPT2,ANGPTL3,AOC1,ASPG,BBX,BIRC2,CD209,CEBPD,CLEC10A,FASN,IFI44,ITGB3,L1CAM,PGK1,RRM2,TMPRSS6,TNFSF14 19 (10) 10 1-methyl-4-phenylpyridinium,6-hydroxydopamine,GAST,l-asparaginase,peroxynitrite deferoxamine,EIF2AK1,NFkB (complex),nifedipine,protocatechuic acid,SOD1 CASP3,caspase,CCND2,MAP3K7,Mt CCNE1,PPP1R15A SDCBP enzyme -0.000 3 -0.120 3.18E-04 2.26E-02 ACHE,AHR,Akt,Ap1,APP,CDC42,CDKN1B,CLOCK,COP1,CREB1,CTNNB1,CXCL8,CYP19A1,EIF4E,ELAVL1,ERK1/2,ESR1,ESR2,ETS2,FADD,Focal adhesion kinase,FOS,GRIN3A,HIF1A,HIPK2,HRAS,IGF1,IL10,IL1B,IL6,IRF3,Jnk,MAPT,MITF,MMP2,MYB,MYC,NEDD9,NFkB (complex),NGEF,P38 MAPK,PPARA,PRKCA,PRKCE,PTK2,RAF1,REL,RICTOR,RXRA,S100A9,SDCBP,SMAD2,SMAD3,SNCA,SOX4,SRC,SRC (family),TGFB1,TGFBR1,TNF,TWIST1,VDR,Vegf,WBP2,WWOX ADRM1,AGA,AIMP2,ALDH7A1,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ASPG,ATL2,B4GALT1,BCHE,BIRC2,BIRC3,CACHD1,CALM1 (includes others),CALML3,CD209,CEBPD,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,CUBN,DGAT1,ETNK1,FASN,FAT4,FGL1,HCRTR2,ITGB3,KRT8,L1CAM,MEGF10,MEGF11,MGAT4C,MKX,NLGN2,NUBP1,PGK1,PIF1,PLG,PTPRK,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A7,SLC5A7,SOD3,SUSD2,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM2,TRIM3,TRIM56,TRPM2,TULP4,XPO7 69 (65) 61 tacrolimus Cofilin,Focal adhesion kinase,NFkB (complex) TJP1 FCGR1A transmembrane receptor 3 -0.775 3.21E-04 2.06E-02 ALK,APP,AR,BCR (complex),CBL,CDKN1B,COP1,CREB1,CYP19A1,EIF2AK3,EIF4E,ELAVL1,ERK1/2,ESR1,ETS2,FADD,FCGR1A,FGFR2,FOS,HCK,HIF1A,HIPK2,HRAS,IGF1,IKZF1,IL10,IL6ST,INSR,Jnk,LCP2,LYN,MAPT,MITF,MYB,MYC,NFATC2,NFkB (complex),NR1I3,P38 MAPK,PAK2,PDPK1,PGR,PI3K (family),PLC,PLCG1,PPARA,PPARGC1A,PRKCE,PTK,RAF1,RB1,RICTOR,S100A9,SHC1,SNCA,SRC (family),STAT1,STAT5a/b,STAT5B,STK11,SYK,TGFB1,TNF,TWIST1 ALDH7A1,ANK1,AOC1,ASPG,ATL2,BBX,BCHE,BIRC2,CACHD1,CALML3,CASP2,CD209,CEBPD,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,CUBN,Cyp2d22,CYP39A1,EMILIN2,ETNK1,FASN,FAT4,FCGBP,GSTM3,ITGB3,MAPK4,MEGF10,MEGF11,MGAT4C,MKX,NLGN2,NUBP1,PIF1,PLG,PNLIP,POU3F3,RAB11A,RRP12,RSL24D1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNR,TPPP3,TRIM3,TRIM56,TRPM2,TULP4,WRN,XPO7 60 (64) 53 NFkB (complex) LAT2,LCP2 IgG complex 3 1.068 3.24E-04 3.30E-02 ACHE,AGT,AHR,Akt,AMPK,APP,ATF4,BCR (complex),CASP3,CDH1,CHRNA7,COP1,Creb,CREB1,CTNNB1,CXCL8,DICER1,EGFR,EIF2AK3,EIF4E,ERK1/2,ESR2,ETS2,Gsk3,HIPK2,HNF4A,IFNAR1,IGF1,IgG,IL10,IL1B,IL6,INSR,IRAK1,IRF3,Jnk,L-type Calcium Channel,lipopolysaccharide,LYN,MAFB,MAPK1,MAPK3,MET,MITF,MLXIPL,MYB,NFkB (complex),NFKBIA,NRAS,NTRK2,P38 MAPK,PLC gamma,PPARA,PRKCE,RAC1,RELA,RICTOR,S100A9,SMAD2,SNCA,SRC,SRC (family),STAT1,TCF7L2,TGFB1,TLR4,TREM2,TWIST1,VDR,WWOX,ZC3H12A ACAA1,AIMP2,ALDH7A1,ANK1,ANOS1,AOC1,ATL2,B4GALT1,BCHE,CALML3,CASP2,CD209,CEBPD,CGAS,CHAC1,CHRNA10,CHRNB3,CLEC10A,CR1,CUBN,DPY19L3,EMX2,FAM111A,FCGBP,FGL1,FLNC,FUT6,GSTM3,IFI44,ITGB3,KIFC1,KMT5A,KRT8,LITAF,LRP5,LRP6,MEGF10,MEGF11,MGAT4C,MKX,NCAN,NLGN2,PIF1,PLG,PLIN2,PNLIP,POU3F3,PTGIR,PTK7,PTPRG,PTPRK,RRM2,RRP12,RSL24D1,SERINC2,SLC5A7,SNAP25,SOD3,SSPOP,SUSD2,SYT12,THSD4,TKFC,TNFSF14,TNXB,TPPP3,TRAF3IP2,TRIM2,TRIM3,VPS25,XPO7 71 (71) 59 CDH17,CLCF1,CX3CL1,ICOS,IL27,POU2AF1,PTTG1,SLC2A1,TNFSF4,TRA,VAV1,WIPF1,zoledronic acid CLEC4A,FASLG,indomethacin,PPARD Complement,Complement component 1,Fc gamma receptor,IFNB1,NFkB (complex),PLC gamma,PPARA,prostaglandin E2,TSC22D3 Ca2+,CASP3,CCL3L3,CCND2,CXCL10,HSPB1,KRT10,KRT18,PEA15,PPP1R15A,ST14,STK24,TACSTD2 DVL1 other 3 0.267 3.29E-04 1.76E-02 ACHE,Akt,Alpha catenin,CaMKII,CTNNB1,DVL1,EGLN,EIF2AK3,EIF4E,ELAVL1,ESR2,FADD,FOS,GSK3B,Hdac,HDAC4,HNF1A,HRAS,IFNG,IRF3,Jnk,KLF6,KRT8,LEF1,LGALS3,MAP2K7,MAP3K1,MAPK8,MAPT,MITF,MYOD1,NGEF,NOTCH1,NRAS,PDPK1,Pkc(s),PPARGC1A,PRKCE,RAC1,Ras homolog,RB1,RHOA,RICTOR,RXRA,S100A8,S100A9,SIRT1,SLC18A3,TAFAZZIN,TCF,TCF4,TCF7L2,TNF,TWIST1 ADRM1,AIMP2,ANGPTL3,ANOS1,ASPG,B4GALT1,BCHE,C1QTNF3,CACHD1,CD209,CGAS,CHRNB3,CLEC10A,DGAT1,EMILIN2,EMX2,ETNK1,FAM111A,FASN,FAT4,FGL1,GNAO1,H2AC21,HCRTR2,KIFC1,KMT5A,L1CAM,Lgals6,LRP4,MAPK4,MEGF10,NANOS1,NLGN2,NUBP1,PIF1,PKD1L2,PLG,PLIN2,PNLIP,PRKCSH,PTPRK,RAB11A,REG1A,RRM2,RRP12,RSL24D1,SCARF1,SLC5A7,SUSD2,SVEP1,TENM3,TNFSF14,TNR,TRIM56,TULP4,VPS25 56 (54) 43 CSNK1D,Frizzled,WNT1,WNT3A,WNT5A L-triiodothyronine Ca2+ phytohemagglutinin chemical drug 2 -0.730 3.30E-04 7.70E-03 Akt,Ap1,EIF4E,ERK,Jnk,Nfat (family),NFkB (complex),phytohemagglutinin,Pkc(s),RB1,RELA,TERT,USP7,USP9X ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANOS1,B4GALT1,BCHE,BIRC2,BIRC3,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CGAS,CLEC10A,DDX20,GLB1,H2BC21,IFI44,ITGB3,KRT8,L1CAM,MAPK4,NLGN2,PLG,PLIN2,RRM2,SOD3,TNFSF14 30 (14) 14 ARR3,Ca2+,CASP3,CCND2,CCR7,CXCL10,ENG,FASLG,FGFR3,FGR,GSTT1,KIT,KLRC4-KLRK1/KLRK1,NFkB (complex),PEMT,PGF,PLC gamma,PLD1,RASA1,RXRA,SPHK1,TERT,TFAM,TFPI,TRAF1,VAMP7 HCFC1 PIK3CA kinase -0.000 3 -1.697 3.33E-04 1.61E-02 26s Proteasome,ACHE,AHR,Akt,APP,ATF4,CDKN2A,CEBPA,DLX5,EIF2AK3,ELAVL1,ERK1/2,ESR2,ETS2,FMR1,Focal adhesion kinase,FOS,FOXO1,FOXO3,GSK3B,HMOX1,HNF4A,HRAS,IL1B,IL6,KLF6,LGALS3,MITF,MLXIPL,MTOR,NFkB (complex),NFKB2,NGEF,NRAS,p70 S6k,PDPK1,phosphatidylinositol,phosphatidylinositol-3,4,5-triphosphate,PI3K (complex),PI3K (family),PIK3CA,PIK3R1,PRKAA,PRKCE,PTK2B,RAC1,RB1,RICTOR,RPS6KB1,SIRT1,SNCA,STAT5B,TCF7L2,TWIST1 ADRM1,AIMP2,ALDH7A1,ANGPT2,ANGPTL3,AOC1,B4GALT1,C1QTNF3,CACHD1,CASP2,CEBPD,CHRNB3,FAM111A,FAT4,FGL1,FUT6,HCRTR2,ITGB3,KMT5A,KRT8,L1CAM,MAPK4,MEGF10,MEGF11,MKX,MMRN1,NUBP1,PIF1,PLG,PNLIP,POU3F3,PRKCSH,RAB11A,RRM2,RRP12,RSL24D1,SCARF1,SLC5A7,SOD3,SYCE2,SYT12,TENM3,THSD4,TKFC,TNFSF14,TPPP3,TRAF3IP2,TRIM3,TULP4,VPS25 50 (54) 41 Ca2+,cytokine receptor,EBF1,G Protein I,INS,tyrosine kinase,WNT3A CAPNS1,mir-182,miR-182-5p (and other miRNAs w/seed UUGGCAA),paraquat,sildenafil,YM-024 CDH5,IRS1,PDGFB,PDK1,phosphatidylinositol,phosphatidylinositol 3,4-diphosphate,POU5F1,RPS6KB1 Focal adhesion kinase,miR-34a-5p (and other miRNAs w/seed GGCAGUG),NFkB (complex),PDGFRA,PIK3CD,PIK3CG CARD8 other 3 -0.700 3.39E-04 4.31E-02 AHR,AKT1,Ap1,CARD8,CASP8,CASP9,CCND1,CEBPA,CSF2,CXCL8,cytokine,ERK1/2,estrogen receptor,HIF1A,HNF4A,IKBKB,IL1B,IL6,JUN,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,P38 MAPK,PAK2,POU2F2,PPARG,PPARα-RXRα,REL,SMAD3,SP1,SRC (family),STAT1,STAT4,STAT5A,TP53 ABCA3,ACAA1,AGA,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CLEC10A,CR1,CSMD3,Cyp2d22,CYP39A1,EMILIN2,FGL1,FLNC,FUT6,GLB1,GNAO1,GSTM3,H2BC21,HNRNPM,HSD3B2,ITGB3,KIFC1,L1CAM,LITAF,LRP6,MATR3,MMRN1,NCAN,PGK1,POLI,PPP1CA,PTPRK,REG1A,SLC16A4,SOD3,SYT12,TMPRSS6,TRAF3IP2,TSG101,WRN 51 (37) 34 tacrolimus caspase,NFkB (complex) bisindolylmaleimide II chemical - kinase inhibitor 3 0.000 3.41E-04 4.76E-02 AHR,Ap1,bisindolylmaleimide II,CCND1,CEBPA,CREB1,CSF2,CXCL8,cytokine,ERK,estrogen receptor,HIF1A,HNF4A,IKBKB,IL1B,IL6,IRF3,JUN,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,POU2F2,PPARG,PPARα-RXRα,REL,SMAD3,SP1,STAT1,STAT4,STAT5A,TP53 ABCA3,ACAA1,ADGRG6,AGA,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CLEC10A,CR1,CSMD3,Cyp2d22,CYP39A1,EMILIN2,FASN,FGL1,FLNC,FUT6,GLB1,GNAO1,GSTM3,H2BC21,HSD3B2,IFI44,ITGB3,KIFC1,L1CAM,LITAF,LRP6,MGAT4C,MMRN1,NCAN,PGK1,POLI,PPP1CA,PTPRK,REG1A,SERINC2,SLC16A4,SOD3,SYT12,TMPRSS6,TRAF3IP2,TSG101 54 (33) 32 NFkB (complex) LPAR1 G-protein coupled receptor 3 -1.588 3.44E-04 2.76E-02 26s Proteasome,ADCY,Akt,AKT1,Ap1,APP,AR,CEBPA,CITED2,COP1,CREB1,CTNNB1,EIF2AK3,EIF4E,ERK,ESR1,ETS2,FADD,FOS,G protein alphai,GLI1,Gα12/13,HIF1A,HNF4A,HRAS,IGF1,IL10,IRF3,Jnk,LPAR1,MAPK1,MAPK8,MITF,MYC,MYCN,NFATC2,NFkB (complex),NGEF,NRAS,P38 MAPK,PDPK1,PGR,PI3K (complex),PLC,PPARA,PPARGC1A,PRKCE,Rac,RAC1,RAF1,REL,RGS4,RHOA,RICTOR,S100A9,SIRT1,SOX2,SPARC,SRF,STK11,TAFAZZIN,TCF7L2,TNF,TNFSF11,Vegf ADGRG6,ADRM1,AGA,AIMP2,ALDH7A1,ANK1,ANOS1,ATL2,B4GALT1,BBX,BCHE,BIRC2,BIRC3,C1QL1,C1QTNF3,CALM1 (includes others),CD209,CHRNB3,CLEC10A,CR1,Cyp2d22,DGAT1,EMILIN2,ETNK1,FASN,FLNC,FRRS1,FUT6,GSTM3,HCRTR2,HNRNPM,IFI44,ITGB3,KMT5A,L1CAM,LRP4,MATR3,MEGF6,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PIF1,PLG,PNLIP,PTPRK,RAB11A,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SSPOP,SUSD2,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TPPP3,TRIM2,TRIM56,TRPM2,VPS25 67 (65) 57 BHLHE40,ziritaxestat zoledronic acid AKT1,SPHK1 NMDA Receptor complex 2 -1.512 3.45E-04 9.10E-03 Calcineurin protein(s),CaMKII,Creb,CREB1,DUSP1,ERK,ERK1/2,GRIN3A,L-glutamic acid,MAPK1,MAPK14,Nfat (family),NMDA Receptor,NRAS,NTRK2,P38 MAPK,Pkc(s),SRC ADGRG6,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CALCRL,CEBPD,CLEC10A,DPY19L3,FLNC,HCRTR2,IFI44,ITGB3,KRT8,LITAF,LRP6,MGAT4C,PGK1,PLIN2,PTPRK,RRM2,SERINC2,SNAP25,TNFSF14,TSG101,TULP4,VPS25 28 (18) 17 acetylcholine,cocaine,CX3CL1,galanthamine,Glycine Receptor,L-cysteine,LRP8,nefiracetam,Nrg1,pregnenolone sulfate,roscovitine,VAMP2 anandamide,D-2-amino-5-phosphonovaleric acid,riluzole ATF3,CASP3,Cofilin,radical,Sapk ARHGAP32,Complement 2-mercaptoethanol chemical - endogenous mammalian 3 -1.361 3.50E-04 2.96E-02 2-mercaptoethanol,26s Proteasome,Ap1,APP,CDKN1B,CREB1,CYP19A1,EIF2AK3,EIF4E,ERBB2,F5,FADD,FOS,GLI1,HIPK2,HMOX1,HNF4A,HRAS,IRF3,Jnk,KRT8,MAPK8,MAPT,MDM2,MYC,NEDD9,NFATC2,NFE2L2,PDPK1,PGR,PRKCE,PTK2,PTPN11,RAF1,RB1,RICTOR,RXRA,SIRT1,SNCA,SRC (family),STAT5B,TNF,TWIST1 ABCA3,ADRM1,ANGPT2,ANGPTL3,ANOS1,ASPG,B4GALT1,BBX,BIRC2,BIRC3,C1QTNF3,CALM1 (includes others),CD209,CHAC1,CHRNB3,CLEC10A,CLPB,CYP39A1,DGAT1,DPY19L3,ETNK1,FAT4,FUT6,GSTM3,H2BC21,HCRTR2,LGMN,MAPK4,MEGF11,MGAT4C,MMRN1,NLGN2,NUBP1,PGK1,PLG,PLIN2,PNLIP,POLI,POU3F3,PTPRK,RAB11A,REG1A,RRM2,RSL24D1,SERINC2,SLC16A7,SOD3,TENM3,THSD4,TNR,TPPP3,TRIM3,TRIM56,XPO7 54 (43) 41 ATF3,SLC2A1 F5,HMOX1 dorsomorphin chemical - kinase inhibitor 3 0.000 3.52E-04 4.10E-02 26s Proteasome,ACHE,AICAR,Akt,AMPK,AR,beta-estradiol,CDK2,CDKN1B,CITED2,COP1,dorsomorphin,doxorubicin,E2F3,EIF4E,EIF4EBP1,ELAVL1,ESR1,ESR2,ETS2,FADD,FMR1,FOS,HIPK2,HNF4A,IGF1,IL10,IL2,IL6,INSR,IRF3,ITGB1,MAP2K1/2,MAPK1,MAPK3,MLXIPL,MYB,MYOD1,NFATC2,NOS3,NR1I2,NRAS,P38 MAPK,PAK1,PDPK1,PI3K (complex),PPARG,PPARGC1A,PRKAA,PRKAA2,PRKCE,PRKCZ,RAF1,RICTOR,RPS6KB1,S100A9,SMAD2,SMARCA4,SNCA,SOX2,SQSTM1,SREBF1,STAT5B,STING1,TGFB1,TP53,TWIST1 ACAA1,ADRM1,AIMP2,AKNA,ANK1,ANOS1,ATL2,B4GALT1,BBX,BCHE,C1QL1,CACHD1,CALCRL,CALML3,CEBPD,CELSR1,CGAS,CHAC1,CHRNB3,CLPB,CR1,CSMD3,Cyp2d22,CYP39A1,DGAT1,DPY19L3,DUT,EMILIN2,ETNK1,FCGBP,FGL1,FLNC,FUT6,GLB1,IFI44,ITGB3,KIFC1,KMT5A,L1CAM,Lgals6,LRP4,LRP6,MEGF10,MEGF11,MKX,NLGN2,NUBP1,PLG,PLIN2,PPP1CA,PTGIR,PTPRK,RAB11A,RRP12,RSL24D1,SLC16A7,SLC5A7,SNAP25,SOD3,SVEP1,SYCE2,SYT12,TKFC,TNFSF14,TNR,TNXB,TRIM3,TRIM36,TRPM2,TSG101,VPS25,XPO7 72 (67) 57 ceramide,RPS6KB1 EP300,IFNB1,LHB,Na+,K+ -ATPase,NPY,Sapk RASGRP1 other 2 Inhibited -2.043 3.54E-04 9.30E-03 Akt,CREB1,CXCL12,ERK,ERK1/2,HRAS,Jnk,KRAS,MAPK1,MAPK8,MAPK9,NRAS,RASGRP1 ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CALCRL,CD209,CEBPD,CLEC10A,DGAT1,FASN,FLNC,IFI44,ITGB3,L1CAM,LITAF,MGAT4C,PLG,PLIN2,PPP1CA,PTPRK,RRM2,SERINC2,SOD3,TENM3,TNFSF14,TULP4,VPS25 29 (13) 12 BHLHE40,Ca2+,L-triiodothyronine,PPARD MRAS HIPK2 kinase -0.000 3 -0.640 3.58E-04 3.47E-02 ACHE,AIRE,Akt,APP,ARNTL,ATM,BHLHE40,CASP3,Cbp/p300,CHEK2,CTNNB1,DICER1,DLX5,E2F3,EIF2AK3,EP300,ESR2,FADD,HDAC3,HIF1A,HIPK2,HMGA1,HNF1A,IL1B,IL6,Jnk,Mapk,MAPK8,MDM2,MITF,MYOD1,NFATC2,NGEF,NOTCH1,NQO1,PDPK1,PPARGC1A,PPIF,PPM1D,PRKCE,RICTOR,SIAH2,SIRT1,SMARCA4,SNCA,STAT3,STING1,T3-TR-RXR,TCF,TCF4,TGFB1,TP53,TSG101,VDR,VitaminD3-VDR-RXR ACAA1,AIMP2,AKNA,ANGPT2,ANK1,B4GALT1,BBX,BIRC3,CALCRL,CALML3,CD209,CEBPD,CELSR1,CGAS,CHAC1,CHRNB3,CLEC10A,CSMD3,CUBN,DGAT1,DUT,EMILIN2,EMX2,ETNK1,FGL1,GLB1,H2BC21,HCRTR2,IFI44,ITGB3,KIFC1,KRT8,Lgals6,LRP5,MEGF11,NANOS1,PIF1,PKD1L2,PLIN2,PNLIP,POU3F3,PPP1CA,PTPRK,RAB11A,RRP12,RSL24D1,SCARF1,SLC16A4,SLC5A7,SOD3,SUSD2,SYT12,THSD4,TMPRSS6,TNFSF14,TPPP3,TRAF3IP2,TRIM3,TRIM36,WRN,XPO7 61 (55) 45 ATP2B2,MAP3K7,quercetin etoposide CCND2,EP300,HMOX1,RAC2 CASP3,NTRK1 1,1-diethyl-2-hydroxy-2-nitrosohydrazine chemical toxicant 3 -1.361 3.62E-04 2.78E-02 1,1-diethyl-2-hydroxy-2-nitrosohydrazine,26s Proteasome,APP,AR,ATF4,COP1,Creb,CREB1,CTNNB1,EGFR,EIF4E,ESR2,estrogen receptor,FADD,GLUL,HIPK2,HNF1A,HNF4A,IFNAR1,ITGB1,Jnk,KMT2A,KRT8,MAPK1,MAPK14,MAPT,MYOD1,NFkB (complex),NFKB2,PPARA,PPARGC1A,PRKAA2,RB1,RICTOR,RXRA,S100A9,sGC,SIRT1,SMAD3,SPP1,STAT4,TGFB1,TNF,TWIST1 ADRM1,ALDH7A1,ANGPTL3,ASPG,BCHE,BIRC3,C1QTNF3,CALML3,CD209,CEBPD,CGAS,CHAC1,CLEC10A,Cyp2d22,CYP39A1,DPY19L3,EMILIN2,ETNK1,FASN,FAT4,FCGBP,FGL1,FLNC,FUT6,GSTM3,HCRTR2,IFI44,KRT8,Lgals6,LRP6,MAPK4,MEGF10,MGAT4C,MKX,NLGN2,PKD1L2,PLG,POU3F3,PTPRK,REG1A,RRM2,RRP12,RSL24D1,SERINC2,SLC5A7,SUSD2,SVEP1,SYT12,THSD4,TNR,TNXB,TPPP3,TRIM56,XPO7 54 (44) 42 IFNB1,sGC MAP3K7 kinase -0.000 2 -1.121 3.66E-04 2.53E-02 Akt,AKT1,Ap1,CHUK,CREB1,CTNNB1,EGFR,ERK,HIPK2,IKBKB,IKBKG,IRF3,JINK1/2,Jnk,JUN,MAP3K7,MAPK1,MAPK14,MAPK3,MAPK8,MAPKAPK2,Mek,NFkB (complex),NFkB (family),NFKB1,P38 MAPK,PRKAA1,SREBF1,SREBF2,STAT3 ACAA1,ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,ANOS1,B4GALT1,BIRC3,CALM1 (includes others),CASP2,CD209,CEBPD,CLEC10A,DGAT1,DPY19L3,FLNC,GLB1,GNAO1,H2BC21,HNRNPM,IFI44,ITGB3,KIFC1,KRT8,LITAF,LRP6,MATR3,MGAT4C,PLG,POLI,PTPRK,REG1A,RRM2,SERINC2,SUSD2,TNFSF14,TNXB,XPO7 39 (30) 30 CALML6,ceramide,doxycycline,etoposide,Hsp90,iron,L-triiodothyronine,PPARD,sorbitol,USP19,WNT1 cryptotanshinone,KN 93,PELI3,PPP3CA,PPP3R1,SOCS3,SUPT20H,tanespimycin,TAP1,UBB AKT1,ATF2,CCR7,CXCL10,HIPK2,HMOX1,JINK1/2,MAP2K4/7,Mapk kinase,NFkB (complex),PRKAA1,Sapk CASP3,PDGFB,SAA1,TERT daunorubicin chemical drug 2 -0.192 3.69E-04 7.40E-03 26s Proteasome,AKT1,BCL2,CHEK1,CYP1B1,daunorubicin,Hif1,Jnk,MAPK1,MAPK3,NFkB (complex),NFKB1,NFKB2,Pkc(s),POR,PRKCZ,RAF1,TERT ADRM1,ALDH7A1,B4GALT1,C1QTNF3,CACHD1,CASP2,CD209,CEBPD,CLEC10A,FASN,FGL1,FLNC,GNAO1,GSTM3,HNRNPM,IFI44,ITGB3,KRT8,MATR3,PGK1,PLG,PTPRK,RRM2,SLC16A7,SNAP25,SOD3,SUSD2 27 (18) 17 AKT1,CASP3,caspase,ceramide,NFkB (complex),TAP1 CDKN2A,PLA2G6,POR,SLC25A4,TERT gimeracil chemical drug 3 0.000 3.73E-04 1.90E-03 Akt,gimeracil,GST,GSTK1,GSTO1,GSTT1,mitomycin C,NOS3,POR AIMP2,BIRC2,CELSR1,CGAS,CHAC1,FGL1,GSTM3,L1CAM,PLG,RRM2,SOD3,SUSD2,TNFSF14,TULP4 14 (9) 7 POR tegafur chemical drug 3 0.000 3.73E-04 1.80E-03 Akt,GST,GSTK1,GSTO1,GSTT1,mitomycin C,NOS3,POR,tegafur AIMP2,BIRC2,CELSR1,CGAS,CHAC1,FGL1,GSTM3,L1CAM,PLG,RRM2,SOD3,SUSD2,TNFSF14,TULP4 14 (9) 7 POR tauroursodeoxycholic acid chemical - endogenous mammalian 2 -1.886 3.76E-04 2.10E-03 ABCB4,Akt,AKT1,ERK1/2,NR1H4,NR1I2,tauroursodeoxycholic acid AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,CGAS,CYP39A1,GSTM3,HNRNPM,HSD3B2,ITGB3,L1CAM,MATR3,PLG,RRM2,SOD3,TNFSF14 18 (7) 6 bile acid,lithocholic acid,TFAM NR5A2 AKT1,Ca2+ caspase USPL1 peptidase -0.000 3 0.700 3.76E-04 4.64E-02 AHR,CCND1,CEBPA,CSF2,CXCL8,cytokine,estrogen receptor,HIF1A,Histone h3,HNF4A,IKBKB,IL1B,IL6,IRF3,JUN,KMT2A,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,POU2F2,PPARG,PPARα-RXRα,REL,SMAD3,SP1,STAT1,STAT4,STAT5A,TP53,USPL1 ABCA3,ACAA1,AGA,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALCRL,CD209,CEBPD,CELSR1,CLEC10A,CR1,CSMD3,Cyp2d22,CYP39A1,EMILIN2,FGL1,FLNC,FUT6,GLB1,GNAO1,GSTM3,H2BC21,HSD3B2,IFI44,ITGB3,KIFC1,L1CAM,LITAF,LRP6,MKX,MMRN1,NCAN,PGK1,POLI,PPP1CA,PTPRK,REG1A,RRM2,SLC16A4,SOD3,SYT12,TMPRSS6,TRAF3IP2,TSG101 51 (32) 31 NFkB (complex) LRP5 transmembrane receptor 2.925 3 -0.283 3.79E-04 1.58E-02 ACHE,Akt,Alpha catenin,APP,CDKN1B,CEBPA,COP1,CTNNB1,DLX5,EIF4E,ERK,ERK1/2,ESR2,ETS2,FADD,GSK3B,HNF1A,HNF4A,IFNAR1,IL10,IRF3,Jnk,KLF6,KRT8,LEF1,LGALS3,LRP5,MAPK14,MYOD1,NGEF,NR1I3,RICTOR,RXRA,S100A9,SIRT1,SPP1,TCF7L2,TGFB1,TNF,VDR ACAA1,ADGRG6,ADRM1,AIMP2,ANGPT2,ANGPTL3,ANOS1,AOC1,BCHE,C1QTNF3,CALML3,CD209,CGAS,CLEC10A,CLPB,CR1,CUBN,CYP39A1,EMX2,ETNK1,FGL1,FUT6,GNAO1,HCRTR2,KIFC1,KMT5A,Lgals6,LRP6,MEGF10,MKX,MMRN1,NLGN2,PGK1,PKD1L2,PLIN2,POU3F3,PRKCSH,REG1A,RRM2,RRP12,RSL24D1,SCARF1,SLC5A7,SUSD2,SYT12,THSD4,TNFSF14,TNR,TPPP3,TRIM56 50 (40) 38 SOX7,WNT3A DAB2,WNT5A LRP6 Ca2+,HNF4A SLC25A4 transporter 3 -0.700 3.83E-04 4.65E-02 AHR,Ap1,CCND1,CEBPA,CSF2,CXCL8,cytokine,estrogen receptor,HIF1A,HNF4A,IKBKB,IL1B,IL6,IRF3,JUN,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,POU2F2,PPARG,PPARα-RXRα,REL,SLC25A4,SMAD3,SP1,STAT1,STAT4,STAT5A,TP53 ABCA3,ACAA1,AGA,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CLEC10A,CLPB,CR1,CSMD3,Cyp2d22,CYP39A1,EMILIN2,FGL1,FLNC,FUT6,GLB1,GNAO1,GSTM3,H2BC21,HSD3B2,IFI44,ITGB3,KIFC1,L1CAM,LITAF,LRP6,MMRN1,NCAN,PGK1,POLI,PPP1CA,PTPRK,REG1A,SLC16A4,SOD3,SYT12,TMPRSS6,TRAF3IP2,TSG101 51 (31) 31 ammonium daunorubicin NFkB (complex) 8(S)-hydroxyeicosatetraenoic acid chemical - endogenous mammalian 3 0.949 3.86E-04 2.58E-02 8(S)-hydroxyeicosatetraenoic acid,ABCB4,Akt,AKT1,Ap1,CEBPA,CTNNB1,CYP19A1,FOXO1,HNF4A,JUN,NFKBIA,P38 MAPK,PAK2,PPARA,PPARD,PPARG,RAF1,RB1,SIRT1,SMAD4,STAT3,STAT5B,TERT ABCA3,ACAA1,AIMP2,ANGPTL3,ANK1,ASPG,CALCRL,CALM1 (includes others),CASP2,CD209,CEBPD,CELSR1,CGAS,CLEC10A,CYP39A1,DGAT1,FASN,FCGBP,FUT6,GLB1,GSTM3,H2BC21,HCRTR2,HNRNPM,HSD3B2,KIFC1,KRT8,MAPK4,MATR3,NCAN,PGK1,PLIN2,POLI,PTPRK,SERINC2,SLC16A7,SUSD2,TNFSF14,TSG101,WRN 40 (24) 23 PPARA,PPARD GPS2 transcription regulator 0.000 3 Activated 2.177 3.91E-04 2.25E-02 ACHE,Akt,AR,ATF4,CD40,CEBPA,COP1,CREB1,CYP19A1,EGFR,EIF2AK3,EIF4E,ESR2,FADD,FOS,FOXO1,GPS2,HIF1A,IGF1,IL2,JINK1/2,Jnk,KRT8,MAPK8,MAPT,mifepristone,MITF,MLXIPL,MYB,NCOR2,NFATC2,NGEF,P38 MAPK,PDPK1,PLA2G2A,PPARA,PPARG,PPARGC1A,PRKCE,progesterone,RB1,RICTOR,S100A9,STAT5B,STK11,TLR7,TNF,TRAF6,TWIST1,VDR ACAA1,AIMP2,ANK1,ASPG,ATL2,B4GALT1,BBX,BCHE,BIRC2,CASP2,CD209,CHAC1,CHRNB3,CLEC10A,CUBN,Cyp2d22,EMILIN2,ETNK1,FAM111A,FASN,FAT4,ITGB3,L1CAM,MAPK4,MEGF10,MGAT4C,MMRN1,NLGN2,NUBP1,PIF1,PLG,PLIN2,PNLIP,PTGIR,RAB11A,REG1A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC5A7,SVEP1,SYT12,TENM3,TKFC,TMPRSS6,TNFSF14,TNR,TNXB,TRIM56,TRPM2,TULP4 54 (50) 47 CCL3L3,CXCL10,JINK1/2,PGR,PID1,RGL1,WIPF1 KRT10 other 2 Activated 2.668 3.91E-04 2.50E-03 Akt,AKT1,Jnk,KRT10,PRKCZ,RB1 AIMP2,ANGPT2,BIRC2,CALCRL,CASP2,CD209,CEBPD,CELSR1,CLEC10A,FASN,H2BC21,HNRNPM,L1CAM,MAPK4,MATR3,RRM2,TNFSF14 17 (6) 5 Ca2+,TINCR CDK4/6,IgG AKT1,CCNE1 IRS1 enzyme 3 -0.126 3.92E-04 2.65E-02 Akt,AKT1,AKT2,BCL2,CDKN2A,CREB1,CXCL8,DLX5,EIF4E,ELAVL1,ERK,ERK1/2,ETS2,FOS,FOXO1,GRB2,Gsk3,HMGA1,HNF4A,IL10,IL1B,IL6ST,INSR,Insulin,IRS1,JUN,MAFB,Mapk,Mek,MITF,MLXIPL,NFATC2,NFkB (complex),NFKB2,NGEF,NRAS,P38 MAPK,p70 S6k,PI3K (complex),PIK3CG,PIK3R1,PPARGC1A,PRKCE,PTK2B,PTPN11,REL,RICTOR,S100A9,SHC1,SNCA,SOX2,SPARC,TCF7L2,TGFB1,TNF,TNFSF11,TWIST1 ABCA3,ADGRG6,AGA,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BBX,BCHE,BIRC3,C1QL1,C1QTNF3,CACHD1,CALML3,CASP2,CEBPD,CGAS,CHRNB3,CR1,DGAT1,EMX2,FAM111A,FASN,FAT4,FCGBP,FRRS1,FUT6,HNRNPM,ITGB3,KMT5A,KRT8,L1CAM,LITAF,LRP4,MATR3,MEGF11,MGAT4C,MKX,NLGN2,NUBP1,PGK1,PIF1,PLG,POLI,POU3F3,PTGIR,RRM2,RSL24D1,SCARF1,SERINC2,SNAP25,SOD3,SVEP1,TKFC,TNFSF14,TNR,TRAF3IP2,TRIM2,TRIM3,TRIM56,VPS25 63 (57) 50 ACSL1,anisomycin,BMP7,C1QTNF12,CAV3,choline,CNTF,D-fructose,deferoxamine,DNM1,EBF1,Evans Blue,FFAR4,forskolin,GKAP1,hydrogen sulfide,indomethacin,JINK1/2,L-cysteine,L-methionine,lactacystin,leukotriene B4,LG100268,MAP2K2,NCOA3,nifedipine,NOX3,PD 169316,PHLPP1,PIK3CA,PIN4,PLA2G6,POU5F1,PRKAA1,PTN,tunicamycin,WNT3A acetyl-L-carnitine,beta-cyclodextrin,CREB3L3,DSCAM,epicatechin,GGPS1,GRK2,MDM2,mir-145,oleic acid,PGR,PHIP,PID1,PRCP,PRNP,RETN,SCD,SOCS3,SOCS6,TBC1D3G (includes others),TFAP2B NFkB (complex) FASLG,HMOX1,PIK3CG SELENOS other -0.000 3 -0.420 3.93E-04 4.57E-02 AHR,Ap1,CCND1,CEBPA,CSF2,CXCL8,cytokine,estrogen receptor,HIF1A,HNF4A,IKBKB,IL1B,IL6,IRF3,JUN,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,POU2F2,PPARG,PPARα-RXRα,REL,SELENOS,SMAD3,SP1,STAT1,STAT4,STAT5A,TP53 ABCA3,ACAA1,AGA,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CLEC10A,CR1,CSMD3,Cyp2d22,CYP39A1,EMILIN2,FASN,FGL1,FLNC,FUT6,GLB1,GNAO1,GSTM3,H2BC21,HSD3B2,IFI44,ITGB3,KIFC1,L1CAM,LITAF,LRP6,MMRN1,NCAN,PGK1,POLI,PPP1CA,PTPRK,REG1A,SLC16A4,SOD3,SYT12,TMPRSS6,TRAF3IP2,TSG101 51 (31) 31 3-deazaneplanocin,ERN1 NFkB (complex) VEGFC growth factor 2 -1.606 3.93E-04 2.80E-03 Akt,AKT1,ERK,ERK1/2,ITGB1,Jnk,KDR,NOS3,p70 S6k,PI3K (complex),VEGFC ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,HNRNPM,L1CAM,LRP6,MATR3,PLG,RRM2,SOD3,TNFSF14,TNXB 19 (11) 10 CALC,CAMP,prostaglandin E2,sildenafil,tacrolimus,TMPRSS2-ERG,VEGFD 8-bromo-cAMP,MEOX2,rofecoxib,WNT1 AKT1,ITGA4,PROX1 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one chemical reagent 1 1.414 3.94E-04 2.50E-03 3-(3-pyridinyl)-1-(4-pyridinyl)-2-propen-1-one BIRC2,BIRC3 2 (1) 1 XPC transcription regulator -0.000 1 -1.414 3.94E-04 3.00E-04 XPC CASP2,POLI 2 (1) 1 benzo(a)pyrene UBB zinostatin biologic drug 2 -0.277 3.99E-04 1.40E-03 ATM,Jnk,MAPK14,MDM2,MDM4,zinostatin BIRC3,CASP2,CD209,CEBPD,CLEC10A,FASN,H2BC21,KRT8,LRP6,PLG,RRM2,TSG101,WRN 13 (6) 5 MDM2 TIRAP other 3 -0.500 4.03E-04 3.52E-02 ACHE,Akt,APP,ATF3,CDKN1B,CEBPA,Creb,CREB1,CTNNB1,CXCL8,CYP19A1,EGFR,EIF2AK2,EIF2AK3,EIF4E,EPAS1,ERK,ERK1/2,ESR2,ETS2,FADD,FOS,HIF1A,HNF1A,HNF4A,IGF1,IL10,IL10RA,IL1B,IRAK1,IRAK2,IRF3,ITGB1,Jnk,JUN,Mapk,MAPK14,MAPK8,MAPKAPK2,MAPT,MITF,MYB,MYD88,MYOD1,NFATC2,NFkB (complex),NFKB2,NFKBIA,P38 MAPK,PKD1,PPARA,PPARGC1A,PRKCE,RB1,RICTOR,S100A9,STAT1,STK11,TIRAP,TNF,TWIST1,ZC3H12A ADGRG6,AIMP2,ALDH7A1,ANK1,ANOS1,AOC1,ASPG,ATL2,B4GALT1,BBX,BCHE,C1QTNF3,CACHD1,CASP2,CD209,CEBPD,CHRNB3,CLEC10A,CLPB,CR1,DGAT1,DPY19L3,ETNK1,FAM111A,FASN,FAT4,FUT6,ITGB3,KRT8,L1CAM,Lgals6,LITAF,LRP6,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NCAN,NLGN2,NUBP1,PIF1,PKD1L2,PLG,PNLIP,POLI,RAB11A,RRM2,RSL24D1,SERINC2,SLC16A4,SLC5A7,SOD3,SUSD2,SVEP1,THSD4,TMPRSS6,TNFSF14,TNR,TNXB,TPPP3,TRAF3IP2,TRIM56,TULP4 64 (62) 58 Pam3-Cys CXCL10,NFkB (complex) IFNB1 oxonic acid chemical drug 3 0.000 4.06E-04 2.20E-03 Akt,GST,GSTK1,GSTO1,GSTT1,mitomycin C,NOS3,oxonic acid,POR AIMP2,BIRC2,CELSR1,CGAS,CHAC1,FGL1,GSTM3,L1CAM,PLG,RRM2,SOD3,SUSD2,TNFSF14,TULP4 14 (9) 7 D-fructose POR Beta Arrestin group 3 0.000 4.10E-04 3.31E-02 ACHE,ADRB2,Akt,Alpha catenin,APP,ARF6,ARRB1,ARRB2,ATF4,Beta Arrestin,CDKN1B,CFTR,Creb,CREB1,CTNNB1,CYP19A1,EIF4E,EP300,ERK,ERK1/2,ESR1,ESR2,ETS2,FOS,FOXA2,FYN,G protein,HCFC1,HIF1A,HIPK2,HNF4A,IL10,IRF3,MAPK10,MAPT,MITF,MYC,MYCN,MYOD1,NFKB2,NFKBIA,NGEF,NR1I3,NRAS,PDPK1,PGR,PPARA,PPARGC1A,PRKCE,PTPRJ,Rac,RAF1,RAS,RB1,REL,RXRA,SIRT1,SMAD2,SNCA,SRC (family),STK11,T3-TR-RXR,TGFB1,TNF,TWIST1,VitaminD3-VDR-RXR ADGRG6,AGA,AIMP2,ANGPTL3,ANOS1,AOC1,ASPG,B4GALT1,BBX,C1QTNF3,CALML3,CHAC1,CHRNB3,CLPB,CR1,CUBN,CYP39A1,DPY19L3,EMILIN2,FAT4,FUT6,GSTM3,HCRTR2,ITGB3,KMT5A,KRT8,L1CAM,Lgals6,LITAF,LRP5,MAPK4,MEGF10,MEGF11,MGAT4C,MKX,NCAN,NLGN2,NUBP1,PGK1,PIF1,PLG,RAB11A,RRM2,RRP12,SCARF1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SOD3,SUSD2,SVEP1,SYT12,THSD4,TMPRSS6,TNFSF14,TNR,TPPP3,TRIM3,TRIM56,TRPM2,TULP4,VPS25,XPO7 64 (66) 56 MDM2 Cofilin,EP300 G protein,OPRK1 NCX-4040 chemical drug 3 1.508 4.16E-04 3.48E-02 2-amino-1-methyl-6-phenylimidazo-4-5-b-pyridine,20s proteasome,acetaminophen,aflatoxin B1,Akt,AKT1,ATM,Calcineurin protein(s),CASP3,CASP9,CCND1,clopidogrel,CTNNB1,CYP,CYP19A1,CYP1A1,CYP1A2,CYP1B1,DICER1,ERK,Jnk,MAPK8,methimazole,NCX-4040,NFkB (complex),NFkB (family),NFKB2,NFKBIA,PAK2,PSMB1,PTEN,PTGS2,REL,TCF7L2,VDR ACAA1,ADGRG6,AGA,AIMP2,ALDH7A1,ANGPT2,ASPG,B4GALT1,BIRC2,BIRC3,C1QTNF3,CACHD1,CALCRL,CD209,CEBPD,CELSR1,CHAC1,CLEC10A,CUBN,DGAT1,DUT,EMX2,GSTM3,HNRNPM,KIFC1,KMT5A,KRT8,LITAF,LRP5,LRP6,MATR3,NANOS1,NCAN,PGK1,PPP1CA,RAB11A,REG1A,RRM2,SOD3,SUSD2,SYT12,TNFSF14,TSG101,WRN 44 (35) 30 CASP3,prostaglandin E2 thyroid hormone chemical - endogenous mammalian 2 0.426 4.27E-04 5.20E-03 Akt,Ap1,CYP19A1,NOS3,Pkc(s),PRKCE,RB1,RBL2,THRB,thyroid hormone,TSH,VDR AIMP2,ANGPTL3,ASPG,BIRC2,BIRC3,CALCRL,CALM1 (includes others),CELSR1,CHRNB3,CUBN,FASN,H2BC21,KIFC1,KRT8,L1CAM,LRP5,MAPK4,PLG,PPP1CA,SOD3,SYT12,TNFSF14 22 (12) 12 DIO1 BCAR1,CDKN2A,levothyroxine,RELN,SSTR5 INHA,RAB2A,ST14 NRP2 kinase -0.000 2 -1.414 4.29E-04 5.70E-03 AKT1,CTNNB1,Focal adhesion kinase,MAPK1,NRP2,PTK2 ACAA1,BIRC2,BIRC3,CEBPD,EMX2,FLNC,HNRNPM,IFI44,ITGB3,KIFC1,KRT8,L1CAM,MATR3,PGK1,PLG,PLIN2,PTPRK,SUSD2 18 (6) 5 ESR2 FOXO4 AKT1,Focal adhesion kinase CASP3 TREM2 transmembrane receptor 3 -1.455 4.33E-04 4.36E-02 26s Proteasome,ACHE,AHR,Akt,Alpha catenin,AR,CBL,Cdc42,CDKN1B,CNTF,CREB1,CTNNB1,CYP19A1,CYP1A1,DLX5,EIF4E,ERK,ERK1/2,ESR1,ESR2,ETS2,FOS,Hdac,HIF1A,HRAS,IFNG,IFNGR1,Ige,IKZF1,IKZF3,IL1B,IL4,IL6ST,IRF3,L-tyrosine,MAPT,NEDD9,NFAT (complex),NFATC2,NFkB (complex),NGEF,NR1I3,PDPK1,PGR,PIK3R1,PLCG1,PPARA,PPARD,PPARGC1A,PTK2,RAC1,REL,SIRT1,STAT4,STAT5B,SYK,TCF7L2,TGFB1,TNF,TREM2,TWIST1,TYROBP,VAMP8,VDR ACAA1,ADGRG6,ADRM1,AGA,AIMP2,ALDH7A1,ANGPT2,ANOS1,AOC1,ARL6IP4,ASPG,BBX,BIRC2,C1QTNF3,CACHD1,CALML3,CASP2,CD209,CEBPD,CGAS,CHAC1,CLPB,CUBN,Cyp2d22,CYP39A1,EMILIN2,EMX2,FASN,FAT4,GNAO1,GSTM3,H2AC21,HCRTR2,IFI44,KIFC1,KMT5A,LRP4,MEGF10,MFSD1,MGAT4C,MKX,NCAN,NLGN2,NUBP1,PGK1,PLG,PLIN2,POU3F3,PTK7,PTPRG,RAB11A,RRM2,RRP12,SCARF1,SERINC2,SLC5A7,SOD3,SUSD2,SVEP1,SYT12,TENM3,TMPRSS6,TNFSF14,TNR,TPPP3,TRAF3IP2,TRPM2,XPO7 68 (64) 55 capivasertib,GRN,ipatasertib,MAP2K2,Secretase gamma CCL3L3,CCR7,LAT2,SULF2 cannabinoid receptor group 3 -0.729 4.34E-04 4.98E-02 Akt,AKT1,Alpha catenin,Ap1,cannabinoid receptor,CAV1,CD28,CDK5,CFTR,CNR1,CNR2,CREB1,CTNNB1,EGF,ERK,FYN,G protein,G protein alphai,GNA12,GNAS,GNB3,HRAS,IKBKB,INSR,IRF3,ITGB1,Jnk,JUN,KRAS,MAPK1,MAPT,Mmp,Nfat (family),NFE2L2,NFkB (complex),NRAS,NTRK2,P38 MAPK,PAK2,PRKCZ,PTPRJ,RAF1,RASGRF1,SNCA,STAT1,STAT3 ACAA1,ADGRG6,AIMP2,ALDH7A1,ANK1,ANOS1,ASPG,BBX,C1QTNF3,CALCRL,CALM1 (includes others),CASP2,CD209,CHAC1,CLEC10A,CUBN,EMX2,FCGBP,FLNC,GLB1,GNAO1,HNRNPM,HSD3B2,KIFC1,LITAF,LRP4,LRP6,MATR3,MEGF11,MGAT4C,MMRN1,NCAN,PLG,POLI,PPP1CA,PTPRK,SERINC2,SLC16A7,SNAP25,SOD3,SUSD2,TENM3,TNFSF14,TRIM3,TULP4,VPS25,WRN 47 (46) 41 anandamide,RELN G protein BCAR1 enzyme 3 -0.762 4.37E-04 2.72E-02 ACHE,AGT,Akt,APP,BCAR1,CDKN1B,CREB1,CYP19A1,EGFR,EIF4E,ERK1/2,ESR1,ESR2,ETS2,FADD,Focal adhesion kinase,FOS,HIF1A,HIPK2,HRAS,IL10,Jnk,KRT8,MAPK8,MAPT,MITF,MMP2,MYC,NEDD9,NFATC2,NGEF,PDPK1,PPARGC1A,PRKCE,PTK2,RAC1,RAF1,RB1,RICTOR,RXRA,SIRT1,SMAD2,SMAD3,SNCA,SRC (family),STAT5B,STK11,TCF7L2,TGFB1,TNF,TWIST1,VDR,WBP2 ADRM1,AIMP2,ANGPT2,ANGPTL3,AOC1,ASPG,B4GALT1,BBX,BIRC2,BIRC3,CALML3,CASP2,CD209,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,CUBN,CYP39A1,DGAT1,EMILIN2,ETNK1,FAT4,HCRTR2,HSD3B2,ITGB3,KMT5A,KRT8,L1CAM,MAPK4,MEGF10,MEGF11,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PIF1,PLG,PTPRK,RAB11A,REG1A,RRM2,RRP12,RSL24D1,SCARF1,SLC16A4,SLC16A7,SLC5A7,SSPOP,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TNXB,TPPP3,TRIM3,TRIM56,TRPM2,XPO7 62 (53) 50 anandamide,Ca2+,Ecm,Fc receptor,thyroid hormone 8-bromo-cAMP,ENG,lactacystin MMP7 Dynamin chenodeoxycholic acid chemical - endogenous mammalian 3 0.535 4.38E-04 2.91E-02 ABCB4,AHR,CASP3,CDKN1B,CEBPA,CFTR,chenodeoxycholic acid,COP1,CREB1,CYP1A2,DICER1,EIF2AK3,EIF4E,ELAVL1,ERBB2,ERK1/2,ETS2,FMR1,FOS,GNE,Hdac,HNF1A,HNF4A,HRAS,IGF1,IL10,INSR,MAPK8,MAPK9,MITF,MYB,NR1H4,NR1I2,NRAS,P38 MAPK,PDPK1,Pkc(s),PPARA,PPARGC1A,PRKCE,RB1,RELA,RPS6KB1,S100A8,S100A9,SIRT1,SLC18A3,STAT5B,TSC1,TWIST1 ACAA1,AGA,ANK1,AOC1,ATL2,B4GALT1,BCHE,BIRC2,CACHD1,CEBPD,CGAS,CHAC1,CHRNB3,CLPB,CR1,CUBN,CYP39A1,DGAT1,DPY19L3,EMX2,FAT4,FCGBP,FGL1,FUT6,GSTM3,HCRTR2,HSD3B2,L1CAM,LITAF,LRP4,LRP5,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PGK1,PIF1,PKD1L2,PLG,PLIN2,PNLIP,POLI,PTPRK,RAB11A,RRM2,SERINC2,SLC5A7,SOD3,SVEP1,SYCE2,SYT12,TENM3,VPS25 56 (50) 46 CASP3,Dgk,Focal adhesion kinase,IFNB1,NR5A2,PPARA,prostaglandin E2,RPS6KB1 aderbasib chemical drug 3 -0.174 4.38E-04 2.11E-02 ADAM10,ADAM17,aderbasib,Akt,AKT1,Ap1,APP,EGFR,ERBB2,ERBB3,ERK,ERK1/2,IGF1R,MAPK1,MAPK3,MDM2,Notch,NOTCH1,P38 MAPK,Ras homolog,STAT3 ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,CALM1 (includes others),CASP2,CD209,CEBPD,CLEC10A,DPY19L3,FLNC,GSTM3,H2BC21,HNRNPM,HSD3B2,IFI44,ITGB3,KRT8,L1CAM,LRP6,MATR3,PGK1,PLG,POLI,POU3F3,THSD4,TNFSF14,TNXB,TPPP3,TSG101,WRN 33 (21) 18 ADAM10 rhesus theta-defensin 2 chemical - endogenous mammalian 3 -0.174 4.38E-04 2.11E-02 ADAM10,ADAM17,Akt,AKT1,Ap1,APP,EGFR,ERBB2,ERBB3,ERK,ERK1/2,IGF1R,MAPK1,MAPK3,MDM2,Notch,NOTCH1,P38 MAPK,Ras homolog,rhesus theta-defensin 2,STAT3 ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,CALM1 (includes others),CASP2,CD209,CEBPD,CLEC10A,DPY19L3,FLNC,GSTM3,H2BC21,HNRNPM,HSD3B2,IFI44,ITGB3,KRT8,L1CAM,LRP6,MATR3,PGK1,PLG,POLI,POU3F3,THSD4,TNFSF14,TNXB,TPPP3,TSG101,WRN 33 (21) 18 ADAM10 rhesus theta-defensin 3 chemical - endogenous mammalian 3 -0.174 4.38E-04 2.11E-02 ADAM10,ADAM17,Akt,AKT1,Ap1,APP,EGFR,ERBB2,ERBB3,ERK,ERK1/2,IGF1R,MAPK1,MAPK3,MDM2,Notch,NOTCH1,P38 MAPK,Ras homolog,rhesus theta-defensin 3,STAT3 ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,CALM1 (includes others),CASP2,CD209,CEBPD,CLEC10A,DPY19L3,FLNC,GSTM3,H2BC21,HNRNPM,HSD3B2,IFI44,ITGB3,KRT8,L1CAM,LRP6,MATR3,PGK1,PLG,POLI,POU3F3,THSD4,TNFSF14,TNXB,TPPP3,TSG101,WRN 33 (21) 18 ADAM10 RPS6KB1 kinase 0.000 3 -1.250 4.39E-04 4.78E-02 ACHE,Akt,Ap1,APP,AR,ATF4,BHLHE40,CDKN1B,CDKN2A,CEBPA,Creb,CREB1,CXCL8,DICER1,E2f,E2F3,EIF2AK3,ESR2,FLNA,FMR1,GLI1,GSK3B,HIF1A,HIPK2,HMOX1,HNF4A,IGF1,IL10,IL1B,IL2,IL6,IRS1,LGALS3,MAPT,MDM2,MITF,MTOR,MTORC1,NFKB1,NGEF,NRAS,PI3K (complex),PPIF,PRKCE,REL,RICTOR,RPS6KB1,SIRT1,STING1,TARBP2,TNF,TP53 AGA,AIMP2,AKNA,ANGPTL3,ANK1,ASPG,ATL2,C1QTNF3,CALCRL,CALM1 (includes others),CASP2,CD209,CEBPD,CELSR1,CGAS,CHAC1,CHRNB3,CLPB,CR1,CSMD3,Cyp2d22,DPY19L3,DUT,FAM111A,FGL1,FUT6,GLB1,GNAO1,H2BC21,HCRTR2,ITGB3,KIFC1,L1CAM,LITAF,LRP5,MEGF10,MGAT4C,MMRN1,PGK1,PIF1,PLG,PNLIP,PPP1CA,PRKCSH,PTGIR,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC5A7,SYCE2,THSD4,TMPRSS6,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM56,TSG101,TULP4,VPS25,WRN,XPO7 64 (52) 44 14,15-epoxyeicosatrienoic acid,[D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin,AKT1,anisomycin,arginine,Ca2+,chenodeoxycholic acid,dorsomorphin,EBF1,FGF9,forskolin,GRN,INS,L-cysteine,L-methionine,L-triiodothyronine,lactacystin,leucine,lonafarnib,MAP3K11,NCOA3,NOX4,Nrg1,p85 (pik3r),PDK1,phospholipid,Pi3k class I,PIK3CA,PIK3R2,PLD1,PPP1R9B,PRKAA1,PRKD3,zinc chloride 3-methyladenine,adaphostin,CGP 74514A,DAB2IP,etoposide,GPSM1,MAP4K4,mir-182,miR-182-5p (and other miRNAs w/seed UUGGCAA),PD173074,phenformin,PHLPP1,phosphatase,piceatannol,prednisolone,quercetin,roscovitine,SPHK1,tosylphenylalanyl chloromethyl ketone CAV3,CCNE1,CXCL10,MDM2 RPS6KB2 LOC102724428/SIK1 kinase 3 1.147 4.40E-04 3.20E-03 ERK1/2,Jnk,LOC102724428/SIK1,MEF2,MEF2A,MEF2D,Na+,K+ -ATPase,NR5A2,PPARG,SRC (family),SREBF1 ACAA1,ANGPT2,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,DPY19L3,FASN,GLB1,HSD3B2,IFI44,ITGB3,PLG,PLIN2,PNLIP,SOD3 19 (11) 9 cocaine,GAST,prednisolone CRTC1 Na+,K+ -ATPase,NR0B1 SCD WNT5A cytokine -0.000 2 -1.890 4.42E-04 9.80E-03 CaMKII,Creb,CTNNB1,ERK,Jnk,MAPK14,MAPK8,MAPK9,NFATC2,NFkB (complex),P38 MAPK,Pkc(s),SETDB1,TERT,WNT5A ACAA1,ADGRG6,ALDH7A1,ANK1,B4GALT1,BBX,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,CSRNP3,DGAT1,DPY19L3,EMX2,FAM234B,GLB1,IFI44,ITGB3,KIFC1,KRT8,L1CAM,LRP5,LRP6,PLG,PTPRK,RRM2,SUSD2 28 (15) 15 8-bromo-cAMP,CNTF,IL11,LIF,POU5F1,quercetin,WNT3A huaier extract granule,MIR17HG,SALL4,SETD2 Ca2+,CXCL10,DVL1,EP300,Frizzled,G protein,IFNB1,KIT,MMP7,NFkB (complex),RAC2,SOCS3,TNFRSF11A,YES1 BTG2,CCL3L3,DAB2,ESR2,HMOX1,ITGA4,LRP5,LRP6,PGF,SDC4,STAMBPL1,TERT CCL3L3 cytokine 3 -0.566 4.43E-04 4.97E-02 AHR,Ap1,CCL3L3,CCND1,CEBPA,CSF2,CXCL8,cytokine,estrogen receptor,HIF1A,HNF4A,IKBKB,IL1B,IL6,IRF3,JUN,LILRB3,NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,POU2F2,PPARG,PPARα-RXRα,REL,SMAD3,SP1,STAT4,STAT5A,TP53 ABCA3,ACAA1,AGA,ALDH7A1,ANK1,ANOS1,AOC1,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CLEC10A,CR1,CSMD3,Cyp2d22,CYP39A1,EMILIN2,FASN,FGL1,FLNC,FUT6,GLB1,GNAO1,GSTM3,H2BC21,HSD3B2,IFI44,ITGB3,KIFC1,L1CAM,LITAF,LRP6,MMRN1,NCAN,PGK1,POLI,PPP1CA,PTPRK,REG1A,SLC16A4,SOD3,SYT12,TMPRSS6,TRAF3IP2,TSG101 50 (31) 30 carbon tetrachloride,CDKN2A,CLEC7A,deferoxamine,GNAI3,lauric acid,LIF,MALP-2s,Map3k7,MOG,peptidoglycan,phospholipid,SAA1,SOST,TREM2,ZEB2,ZFTA-RELA 8-(4-chlorophenylthio)-guanosine-3', 5'-cyclic monophosphate,CISH,CYP27B1,GPS2,IgG,indomethacin,LAT2,PPARD,prostaglandin E2,PTAFR,rhesus theta-defensin 1,Trolox C,USP18,WNT3A,WNT5A Ca2+,leukotriene B4 CCN5 growth factor 3 -0.962 4.48E-04 3.15E-02 AKT1,Alpha catenin,APP,CCN5,CDKN1B,CITED2,Creb,CREB1,CTNNB1,DIO2,EIF4E,ETS2,HIF1A,HNF1A,HRAS,Jnk,KRT8,LEF1,LRP6,MAPK1,MKNK1,MYB,NRAS,PDPK1,phenylephrine,RB1,RICTOR,SREBF1,SREBF2,STK11,TCF/LEF,TCF4,Tcf7,TCF7L2,TNF,VDR ACAA1,BBX,BIRC3,C1QTNF3,CD209,CLEC10A,CLPB,CUBN,DPY19L3,EMX2,FAM111A,FASN,FGL1,FLNC,FUT6,GNAO1,GSTM3,H2BC21,HNRNPM,IFI44,ITGB3,KIFC1,KMT5A,KRT8,L1CAM,MAPK4,MATR3,MEGF10,MGAT4C,MKX,NANOS1,NLGN2,PGK1,PKD1L2,PLG,PLIN2,POU3F3,PTPRK,RAB11A,REG1A,RSL24D1,SERINC2,SLC16A4,SUSD2,SYCE2,TENM3,THSD4,TMPRSS6,TNR,TPPP3,TRIM56,TULP4,VPS25 53 (36) 33 EPAS1,PGR,SEMA7A,tributyltin,WNT1,WNT3A miR-34a-5p (and other miRNAs w/seed GGCAGUG),S100A9,SALL4 KRT18,LRP6,SDC4 PROCR caffeic acid phenethyl ester chemical drug 3 -0.378 4.48E-04 3.98E-02 AGT,AHR,AKT1,ALOX5,BHLHE40,caffeic acid phenethyl ester,CAT,CDKN1B,CDKN2A,CYP19A1,diethylnitrosamine,EGFR,EIF2AK3,ERK1/2,ESR2,ETS2,FADD,FAS,HMOX1,HRAS,hydrogen peroxide,IFNG,IGF1,IL1B,IL6,MAP2K1,MAPK8,MMP9,MYB,MYOD1,NFATC2,NFkB (complex),nitric oxide,NRAS,P38 MAPK,PAWR,PDPK1,PGF,PI3K (complex),PPARGC1A,PRKCE,REL,RELA,RICTOR,S100A9,SIRT1,SOX2,SPARC,TGFB1,TNF,TNFSF11,TP53,Vegf AGA,ALDH7A1,ANGPTL3,ANK1,AOC1,ASPG,ATL2,BBX,BCHE,BIRC3,C1QL1,CALM1 (includes others),CALML3,CASP2,CHAC1,CHRNB3,CLPB,CSMD3,DGAT1,DUT,EMILIN2,ETNK1,FAM111A,FASN,FGL1,FRRS1,GLB1,H2AC21,HCRTR2,HNRNPM,KIFC1,KRT8,L1CAM,Lgals6,LRP4,MATR3,MKX,NANOS1,PLG,PLIN2,PNLIP,PPP1CA,PRKCSH,PTPRK,RAB11A,RRM2,RRP12,RSL24D1,SCARF1,SLC16A4,SLC5A7,SOD3,SSPOP,SVEP1,TENM3,TNFSF14,TNXB,TRAF3IP2,TRIM2,TRIM56,TSG101,TULP4,VPS25 63 (53) 47 CASP3,HMOX1 AKT1,CCNE1,CDKN2A,CXCL10,Hsp90,HSPB1,IGFBP6,IL27,NFkB (complex),PLD1,RXRA,ST13 GnRH-A chemical reagent 3 -1.500 4.51E-04 3.31E-02 Ap1,APP,AR,CDKN1B,CEBPA,CITED2,COP1,CREB1,EIF2AK3,EIF4E,ELAVL1,ERK,ESR1,ETS2,FOS,GnRH-A,HIF1A,HNF4A,HRAS,IGF1,MAPK1,MAPK3,MAPK8,MAPK9,MDM2,Mek,MITF,MYB,MYC,MYCN,MYOD1,NFATC2,NFKBIA,P38 MAPK,PGR,PPARA,PPARGC1A,PTK2B,RAF1,RB1,REL,RICTOR,S100A9,SHC1,SIRT1,SNCA,Sos,SREBF2,STAT4,STAT5B,TCF7L2 ADGRG6,AGA,ANGPT2,ANK1,ATL2,B4GALT1,BBX,BCHE,BIRC3,CACHD1,CALCRL,CALM1 (includes others),CASP2,CEBPD,CELSR1,CHAC1,CLPB,Cyp2d22,CYP39A1,DGAT1,EMILIN2,FASN,FLNC,FUT6,GSTM3,H2BC21,HCRTR2,IFI44,ITGB3,KIFC1,KMT5A,Lgals6,LITAF,MAPK4,MEGF10,MEGF11,MGAT4C,MKX,MMRN1,NCAN,NLGN2,NUBP1,PIF1,PLIN2,PNLIP,POU3F3,PTPRK,REG1A,RRM2,RSL24D1,SERINC2,SLC16A4,SLC16A7,SOD3,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TPPP3,TRIM3,TRPM2,TULP4,WRN 64 (51) 48 ATF3,BTG2,CGB3 (includes others),LHB,MAP3K11,PPP1R15A,RRAD EIF2AK1,FANCC BHLH group 3 0.775 4.52E-04 2.80E-03 Akt,BHLH,BHLHA15,BHLHE40 AIMP2,ALDH7A1,BIRC2,CALCRL,FASN,GSTM3,KRT8,L1CAM,PGK1,PLG,PLIN2,REG1A,RRM2,SCARF1,TNFSF14 15 (4) 3 12(S)-hydroxyeicosatetraenoic acid chemical - endogenous non-mammalian 3 -1.116 4.53E-04 3.34E-02 12(S)-hydroxyeicosatetraenoic acid,ABCG1,AHR,ALOX5,ATF4,CDKN1B,CEBPA,COP1,Creb,CREB1,CXCL8,CYP19A1,EGFR,EIF2AK3,EIF4E,ELAVL1,ERK1/2,ESR1,ETS2,FADD,Focal adhesion kinase,FOS,Hdac,HIF1A,HNF4A,HRAS,IGF1,IL10,IL1B,IL2,IL6,ITGB1,Jnk,MAPT,Mek,MITF,MYB,NFATC2,NFkB (complex),NFKB2,NRAS,P38 MAPK,PDPK1,PPARD,PPARG,PPARGC1A,progesterone,RAS,RB1,REL,RICTOR,S100A9,SIRT1,STAT5B,TCF7L2,TGFB1,TNF,TWIST1 ACAA1,AGA,ALDH7A1,ANGPT2,ANGPTL3,ANK1,AOC1,ASPG,ATL2,BBX,BCHE,BIRC2,BIRC3,C1QTNF3,CACHD1,CALML3,CASP2,CD209,CEBPD,CGAS,CHAC1,CLEC10A,CLPB,CR1,CYP39A1,DGAT1,DPY19L3,ETNK1,FAM111A,FASN,FAT4,FCGBP,FGL1,FUT6,HCRTR2,KMT5A,KRT8,LRP4,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PIF1,PLG,PLIN2,PNLIP,PTGIR,RAB11A,RRM2,RSL24D1,SERINC2,SOD3,SVEP1,SYT12,TENM3,TMPRSS6,TNR,TNXB,TRAF3IP2,TRIM56,TRPM2,VPS25 65 (58) 55 Ca2+,Focal adhesion kinase,NFkB (complex),PPARD FASLG cytokine 3 -0.128 4.57E-04 2.14E-02 26s Proteasome,ACHE,AGT,AHR,Akt,Ap1,APP,CASP3,CASP8,caspase,CDKN1B,COP1,CXCL8,DICER1,EGFR,ERK,ERK1/2,ESR2,ETS2,FAS,FASLG,FYN,HIF1A,HNF1A,HNF4A,HRAS,IFNAR1,IFNG,IGF1,IL10,IL1B,IL2,Jnk,LEF1,MAPK1,MAPK14,MAPK3,MAPK8,MITF,MYB,MYOD1,NEDD9,Nfat (family),NFkB (complex),NGEF,P38 MAPK,PKD1,PTK2B,RB1,REL,RICTOR,S100A9,SNCA,SRC,STK11,TGFB1,TNF,WBP2,WWOX,YES1 ADGRG6,ADRM1,AGA,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,ATL2,B4GALT1,BCHE,BIRC2,CALM1 (includes others),CALML3,CD209,CGAS,CHAC1,CLEC10A,CLPB,CR1,DGAT1,FLNC,FUT6,GNAO1,H2AC21,IFI44,L1CAM,Lgals6,LRP5,LRP6,MAPK4,MEGF10,MEGF11,MKX,PGK1,PIF1,PKD1L2,PLG,PTGIR,PTPRK,RRM2,RRP12,RSL24D1,SCARF1,SLC16A4,SLC5A7,SOD3,SSPOP,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TNXB,TPPP3,TRAF3IP2,TRIM2,TRIM3,TRIM56,TULP4 61 (60) 53 Ahr-aryl hydrocarbon-Arnt,anisomycin,Ca2+,camptothecin,carmustine,CK1,doxycycline,etoposide,Focal adhesion kinase,FOXO4,histone deacetylase inhibitor,JINK1/2,mitomycin C,paraquat,phytohemagglutinin,RPSA,Sapk,selenodiglutathione,teriflunomide AKT1,aloxistatin,ANGPT1,deferoxamine,EPAS1,forskolin,HAS1,IL27,IRS1,KLRC4-KLRK1/KLRK1,L-triiodothyronine,lactacystin,LG100268,linsidomine,NLRX1,sanguinarine,tacrolimus,TSC22D3 CASP3,caspase,ceramide,CXCL10,Notch,YES1 IgG LY83583 chemical reagent 3 0.781 4.62E-04 1.88E-02 AKT1,APP,COP1,CTNNB1,EGFR,EIF2AK3,EIF4E,ERK,HIF1A,HNF1A,HNF4A,IFNAR1,INSR,IRF3,KRT8,LIPE,LY83583,MAPK14,MAPK8,MYOD1,NFATC2,PPARA,PPARG,PPARGC1A,RB1,RICTOR,S100A9,SPP1,STAT4,TGFB1 ACAA1,ADGRG6,ANOS1,B4GALT1,BBX,BCHE,BIRC3,CALML3,CGAS,Cyp2d22,CYP39A1,DGAT1,EMILIN2,FASN,FCGBP,FGL1,FUT6,GSTM3,H2BC21,HNRNPM,ITGB3,Lgals6,LRP6,MAPK4,MATR3,NCAN,NLGN2,PKD1L2,PLIN2,PNLIP,POU3F3,REG1A,RSL24D1,SLC16A4,SUSD2,SVEP1,SYT12,THSD4,TMPRSS6,TNXB,TPPP3 41 (30) 29 Ca2+ HMOX1 rhesus theta-defensin 1 chemical - endogenous mammalian 3 -0.174 4.64E-04 2.25E-02 ADAM10,ADAM17,Akt,AKT1,Ap1,APP,EGFR,ERBB2,ERBB3,ERK,ERK1/2,IGF1R,MAPK1,MAPK3,MDM2,Notch,NOTCH1,P38 MAPK,Ras homolog,rhesus theta-defensin 1,STAT3 ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,CALM1 (includes others),CASP2,CD209,CEBPD,CLEC10A,DPY19L3,FLNC,GSTM3,H2BC21,HNRNPM,HSD3B2,IFI44,ITGB3,KRT8,L1CAM,LRP6,MATR3,PGK1,PLG,POLI,POU3F3,THSD4,TNFSF14,TNXB,TPPP3,TSG101,WRN 33 (21) 18 ADAM10,CCL3L3 ATR kinase -0.000 1 -1.732 4.72E-04 6.00E-04 ATR POLI,RRM2,WRN 3 (1) 1 camptothecin,CDKN2A,etoposide,HMOX1 Hsp90 ATF2,CASP3,MDM2,RRM2 NFkB (complex) carbon tetrachloride chemical toxicant 3 1.432 4.72E-04 3.34E-02 2-amino-1-methyl-6-phenylimidazo-4-5-b-pyridine,26s Proteasome,ACHE,AHR,AKT1,AMPK,APP,carbon tetrachloride,CASP1,CASP8,CAT,CEBPB,CXCL8,CYP1A2,CYP2E1,DIO2,DIO3,ERN1,ESR2,ethanol,ETS2,F2,FADD,FOXO3,glutathione peroxidase,GSTK1,HIF1A,HRAS,hydrogen peroxide,IGF1,IL1,IL1B,IL6,Jnk,JUN,MLXIPL,MYB,NFkB (complex),NFKB1,NR1I2,P38 MAPK,PPARGC1A,REL,RELA,RICTOR,S100A9,SIRT1,SLCO1C1,SOD1,SOD2,SOX2,SPARC,STAT3,STK11,TNF,TNFSF11,VitaminD3-VDR-RXR ADAMTS16,ADRM1,AGA,ALDH7A1,ANGPT2,ANK1,AOC1,ATL2,B4GALT1,BCHE,BIRC3,C1QL1,CACHD1,CASP2,CD209,CGAS,CLEC10A,CR1,Cyp2d22,CYP39A1,DGAT1,DUT,EMILIN2,ETNK1,FGL1,FRRS1,GNAO1,GSTM3,HCRTR2,HNRNPM,ITGB3,LGMN,LRP4,LRP5,MATR3,MKX,PGK1,PLG,PLIN2,POLI,POU3F3,PRKCSH,RAB11A,RRM2,RRP12,RSL24D1,SLC16A4,SLC5A7,SOD3,SVEP1,SYCE2,TENM3,TKFC,TMPRSS6,TPPP3,TRAF3IP2,TRIM2,TRIM56,TULP4 59 (57) 47 AKT1,ATF3,Ca2+,CASP3,CCL3L3,CXCL10,ERN1,FGFR4,HMOX1,NFkB (complex),PDGFB,PDGFC,PDGFD,PDGFRA,PTAFR,RBP1,SLC2A1,SPHK1 ACHE,L-triiodothyronine,levothyroxine,Mt,SOD1 IL27 cytokine 3 Inhibited -2.216 4.94E-04 4.39E-02 Akt,Ap1,CASP3,CASP8,CDKN1B,COP1,CREB1,CYP19A1,DICER1,DLX5,EGFR,EIF4E,ERK,ERK1/2,ESR1,ESR2,ETS2,FOS,HIF1A,Ige,IGF1,IL1,IL10,IL10RA,IL1B,IL27,IL4,IL6,IL6ST,IRF3,ITGB1,MAPT,mir-21,MITF,MYB,MYC,MYCN,NFATC2,NFkB (family),NFKB2,NGEF,NR1I3,P38 MAPK,PGR,PPARA,PPARGC1A,RAF1,RB1,RXRA,S100A9,SIRT1,STAT1,STAT3,STAT4,STAT5B,STAT6,STK11,TNF,TWIST1,Vegf ADGRG6,AIMP2,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ASPG,ATL2,BBX,BCHE,BIRC2,BIRC3,C1QTNF3,CACHD1,CALM1 (includes others),CASP2,CD209,CEBPD,CGAS,CLPB,CR1,Cyp2d22,CYP39A1,EMILIN2,FASN,FAT4,FCGBP,FGL1,GSTM3,HCRTR2,IFI44,ITGB3,L1CAM,LRP5,MAPK4,MEGF10,MGAT4C,MKX,NLGN2,NUBP1,PGK1,PIF1,PLG,POU3F3,PTPRG,REG1A,RRP12,SCARF1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SVEP1,SYT12,THSD4,TMPRSS6,TNFSF14,TNR,TNXB,TPPP3,TRAF3IP2,TRIM56,TRPM2,TULP4,XPO7 66 (60) 57 CGB3 (includes others),IFNB1,MOG,NFkB (complex) caffeic acid phenethyl ester CCL7,CCND2,CX3CL1,CXCL10,CXCL9,ICOS,IgG,Mt,SOCS3,TAP1 CASP3,CD63,FASLG TFAM transcription regulator 2 0.000 4.94E-04 2.70E-03 Akt,ERK1/2,IRS1,TFAM AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,ITGB3,L1CAM,PGK1,PLG,RRM2,SERINC2,TNFSF14 14 (4) 4 acetyl-L-carnitine,BMP7,EP300,Mt,phytohemagglutinin,PRKAA1,quercetin,telmisartan,TRIB1 INS,NOX4 ACADS,PPARA,taurocholic acid,tauroursodeoxycholic acid N-acetyl-L-aspartic acid,SLC2A1 MGAT3 enzyme 2 0.728 4.95E-04 3.50E-03 CTNNB1,ERK1/2,Focal adhesion kinase,Jnk,MGAT3,PRKCD ACAA1,ANGPT2,AOC1,BIRC2,BIRC3,CD209,CLEC10A,EMX2,FASN,ITGB3,KIFC1,KRT8,L1CAM,PGK1,PLG,PLIN2,SUSD2 17 (6) 5 ESR2,forskolin CDH2,Focal adhesion kinase CAMP other 3 0.000 4.95E-04 2.58E-02 26s Proteasome,ACHE,AGT,AHR,Akt,ALOX5,APP,AR,ATF4,CAMP,CASP1,CASP3,CDKN1B,CEBPA,CFTR,CHRNA7,Creb,DICER1,DIO2,E. coli B4 lipopolysaccharide,EPAS1,EPHB2,ERK,ERK1/2,ESR2,ETS2,Focal adhesion kinase,GLI1,HIF1A,HNF4A,HRAS,IL1,IL10RA,IL1B,Interferon alpha,IRF3,Jnk,Mapk,mir-21,MITF,Mmp,MYB,NFATC2,NFKB2,NFKBIA,NR1I3,Pka,PPARD,PPARGC1A,PRKCE,RB1,REL,RELA,RICTOR,STAT3,STK11,TGFB1,thyroid hormone,TLR7,TLR9,TNF,TNFSF11,TWIST1 ADGRG6,ADRM1,AGA,AIMP2,ANGPT2,ANOS1,AOC1,BBX,C1QTNF3,CACHD1,CALML3,CASP2,CD209,CGAS,CHAC1,CHRNA10,CHRNB3,CLEC10A,CLPB,CUBN,Cyp2d22,CYP39A1,DPY19L3,EMILIN2,ETNK1,FAT4,FRRS1,FUT6,IFI44,KRT8,L1CAM,LITAF,LRP5,MAPK4,MEGF10,MKX,MMRN1,NCAN,PGK1,PIF1,PLG,RRM2,RRP12,RSL24D1,SERINC2,SLC16A4,SLC5A7,SOD3,SSPOP,SVEP1,SYCE2,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM56,TRPM2,TULP4 62 (63) 54 4-phenylbutyric acid,8-bromo-cAMP,deferoxamine,forskolin,lithocholic acid,MALP-2s,NFkB (complex) CASP3,CCL7,CXCL10,DIO2,Focal adhesion kinase,IFNB1,IL31,VEGFC CCR7 lonafarnib chemical drug 3 -1.414 5.00E-04 2.67E-02 ACHE,AHR,Akt,APP,ATF4,CASP3,CASP8,CDKN2A,CEBPA,CXCL8,DICER1,DLX5,EGFR,ELAVL1,ESR2,farnesyl transferase,FMR1,FOS,FOXO1,GSK3B,Hdac,HDAC6,HNF4A,HRAS,IL6,IRF3,KLF6,LGALS3,lonafarnib,Mek,MITF,MLXIPL,NFkB (complex),NFKB2,NFKBIA,NGEF,NR1I2,NRAS,p70 S6k,PLAU,PPARGC1A,PSEN1,RAS,RICTOR,RPS6KB1,SIRT1,SREBF2,TCF7L2,TGFB1 ADRM1,AIMP2,ALDH7A1,ANGPTL3,ANOS1,BIRC2,BIRC3,C1QTNF3,CACHD1,CALML3,CHAC1,CR1,CYP39A1,FAM111A,FGL1,FUT6,HCRTR2,ITGB3,KMT5A,KRT8,L1CAM,LITAF,LRP4,LRP5,MEGF10,MMRN1,NCAN,NUBP1,PIF1,PLG,POU3F3,PRKCSH,REG1A,RRM2,RRP12,RSL24D1,SCARF1,SLC5A7,SOD3,SVEP1,SYCE2,SYT12,TENM3,THSD4,TKFC,TNFSF14,TNXB,TPPP3,TULP4,VPS25 50 (49) 40 CASP3,RPS6KB1 NFkB (complex),TRAF1 RELN peptidase 0.000 3 -0.295 5.03E-04 1.61E-02 26s Proteasome,ACHE,Akt,AKT1,ALK,APP,CD28,CDK5,EIF4E,ESR2,ETS2,FADD,FGFR2,FOS,FYN,GRIN3A,GSK3B,HMOX1,HRAS,IL10,KLF6,LGALS3,MAPT,MITF,NGEF,NOTCH1,NR1I2,NRAS,NTRK2,PAWR,PI3K (complex),PRKCZ,PTK,REL,RELN,SNCA,SOX2,SP1,SPARC,SRC,STAT5B,TNFSF11,VitaminD3-VDR-RXR,WBP2,WWOX,YES1 ADRM1,AGA,AIMP2,ANGPTL3,ASPG,BCHE,C1QL1,CASP2,CEBPD,CHAC1,CR1,CUBN,CYP39A1,ETNK1,FASN,FRRS1,GLB1,HCRTR2,HNRNPM,ITGB3,KRT8,L1CAM,LRP4,LRP5,MATR3,MEGF11,MKX,MMRN1,NLGN2,NUBP1,PGK1,PIF1,PRKCSH,PTPRK,RRP12,SCARF1,SLC5A7,SNAP25,TENM3,THSD4,TNFSF14,TNR,TRIM2,TRIM3,TULP4,VPS25 46 (46) 40 thyroid hormone HMOX1,L-triiodothyronine,miR-128-3p (and other miRNAs w/seed CACAGUG),Secretase gamma,WNT1 AKT1,cannabinoid receptor,Integrin alpha 3 beta 1,RAPGEF1,YES1 nelfinavir chemical drug 1 Inhibited -2.236 5.04E-04 1.10E-03 nelfinavir AKNA,CHAC1,DGAT1,MEGF10,SSPOP 5 (1) 1 ATF3,HMOX1,PPP1R15A,RNF41,TSC22D3 AKT1 miR-34a-5p (and other miRNAs w/seed GGCAGUG) mature microRNA 2 1.500 5.05E-04 2.10E-03 miR-34a-5p (and other miRNAs w/seed GGCAGUG),RB1,SIRT1 ANGPT2,BIRC3,CACHD1,CALCRL,CELSR1,CLEC10A,FASN,H2BC21,HCRTR2,IFI44,ITGB3,MAPK4,PGBD4,RRM2,SOD3,TSG101 16 (3) 3 IFNB1,PPARA PIK3CA,RPL22 ATF3,CCN5,E2F2,LGALS3BP,POU5F1,WNT1 indomethacin chemical drug 1 1.414 5.12E-04 1.30E-03 indomethacin ABCA3,ANGPT2,BIRC3,DGAT1,FASN,GSTM3,KRT8,PLIN2 8 (1) 1 ACSL1,CASP3,caspase,CYP2B6,HMOX1,IRS1,leukotriene B4,PPARA,RXRA,TJP1,TMSB4 AKT1,ANGPT1,BTG2,Ca2+,CCL3L3,Collagen type II,IgG,MFN2,NFkB (complex),PPARD,prostaglandin E2 CDX1 transcription regulator 2 1.789 5.17E-04 5.90E-03 CDK2,CDX1,CTNNB1,KLF5,PI3K (complex),RB1,SALL4 ABCA3,ACAA1,ANGPT2,BIRC3,CALCRL,CEBPD,CELSR1,EMX2,FASN,FLNC,H2BC21,KRT8,L1CAM,LITAF,MAPK4,PGK1,PLIN2,RRM2,SNAP25,SUSD2 20 (7) 6 NFkB (complex),WNT1 SALL4 ALDH3A1,CCND2,FOXQ1,TFF2 LIF cytokine 2 Inhibited -2.535 5.17E-04 2.07E-02 Akt,AKT1,CaMKII,CREB1,ERK,ERK1/2,HNF1A,IL6ST,JAK,Jnk,LIF,MAP2K1,MAPK1,MAPK3,P38 MAPK,PI3K (complex),PIM1,RAF1,STAT1,STAT3,STAT4,STAT5A,YAP1 ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CGAS,CLEC10A,Cyp2d22,FGL1,FLNC,FUT6,GLB1,HNRNPM,HSD3B2,IFI44,ITGB3,L1CAM,LITAF,MATR3,MGAT4C,PGK1,PKD1L2,PLG,PTPRK,RRM2,SERINC2,SLC16A7,SLC5A7,TNFSF14,TRPM2 35 (23) 23 8-bromo-cAMP,BHLHE40,CNTF,PROCR AKT1,BMP7,CCL3L3,CCNE1,CDH5,CISH,CXCL10,cytokine receptor,FGF4,NMI,PLD1,RGS4,SOCS3,TMEM176B,WNT5A AHNAK,anandamide,CASP3,DSPP,IBSP,PGR RETN other 3 -0.911 5.25E-04 2.48E-02 AKT1,AMPK,APP,AR,ARNTL,ATF2,CAT,CITED2,COP1,doxorubicin,EIF2AK3,ELAVL1,ERK1/2,ESR2,ETS2,FOS,HIPK2,HNF4A,hydrogen peroxide,IGF1,IL10,IL6,IL6ST,Insulin,IRF3,IRS,Mapk,MAPK1,MITF,MLXIPL,MMP2,NFATC2,NFKB1,NOS3,NRAS,P38 MAPK,PAWR,PDPK1,PRKAA,PTPRJ,RAC1,RETN,RICTOR,S100A9,SIRT1,SMARCA4,SNCA,SOX2,SPARC,SRC (family),STAT3,STK11,TCF7L2,TNFSF11,TSC1 AGA,ANGPT2,ANK1,ANOS1,AOC1,ATL2,BBX,BCHE,BIRC2,BIRC3,C1QL1,CACHD1,CD209,CGAS,CHAC1,CR1,Cyp2d22,DGAT1,DUT,FASN,FGL1,FLNC,FRRS1,FUT6,GNAO1,HCRTR2,HNRNPM,HSD3B2,IFI44,ITGB3,KMT5A,LRP4,MATR3,MEGF11,MKX,NUBP1,PIF1,PLG,PNLIP,POU3F3,PRKCSH,PTPRK,RAB11A,RRP12,RSL24D1,SLC16A4,SLC5A7,SNAP25,SOD3,SYT12,THSD4,TKFC,TNR,TPPP3,TRIM2,TRIM3,TRIM36,VPS25,XPO7 59 (55) 49 ESR2 LPIN1 AKT1,ATF2,CX3CL1,fatty acid,HMOX1,NPY,SOCS3 IRS,IRS1 MERTK kinase 3 -0.896 5.32E-04 3.22E-02 ACHE,Akt,Ap1,APP,AR,CBLB,COP1,CREB1,CYP19A1,EIF2AK3,EIF4E,EPAS1,ERK1/2,ESR2,ETS2,FOS,HIF1A,HIPK2,HNF4A,HRAS,IGF1,IL10,IL6ST,Mapk,MAPK8,MAPT,MERTK,MITF,MYB,MYC,NFATC2,NFKB2,NGEF,NRAS,P38 MAPK,PGR,PPARA,PPARGC1A,PRKCE,PTPN11,RAF1,RB1,REL,RHOA,RICTOR,Rsk,S100A9,SNCA,SRC (family),STAT3,STK11,TGFB1,TLR3,TWIST1,Vegf ABCA3,AGA,AIMP2,ANGPT2,ANK1,AOC1,ASPG,ATL2,B4GALT1,BBX,BCHE,BIRC2,BIRC3,C1QTNF3,CALM1 (includes others),CALML3,CD209,CEBPD,CGAS,CHAC1,CHRNB3,CR1,Cyp2d22,DGAT1,EMILIN2,FASN,FAT4,FUT6,GSTM3,ITGB3,L1CAM,MAPK4,MEGF10,MEGF11,MGAT4C,MKX,NLGN2,NUBP1,PGK1,PIF1,PLG,PNLIP,PPP1CA,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TPPP3,TRIM3,VPS25,XPO7 61 (55) 50 BHLHE40,etoposide,GW3965,PPARD,PROS1 GRN,MRX-2843 IFNB1 ALRN-6924 biologic drug 2 -0.447 5.34E-04 4.00E-04 ALRN-6924,MDM2,MDM4 CASP2,H2BC21,KRT8,TSG101,WRN 5 (3) 2 MDM2 mir-182 microRNA 1 -1.342 5.34E-04 1.60E-03 mir-182 CASP2,CLEC10A,DGAT1,LRP6,NLGN2 5 (1) 1 forskolin,PPARA CHI3L1,CLEC7A,SOCS3 ITGA4,LRP6,MTSS1,PGF,PIK3CA,RASA1,RPS6KB1,SLC30A7,TJP1 isatin chemical - endogenous mammalian 3 0.926 5.35E-04 3.70E-02 AHR,Ap1,CCND1,CEBPA,CSF2,CXCL8,cytokine,ERK1/2,estrogen receptor,HIF1A,HNF4A,IKBKB,IL1B,IL6,IRF3,isatin,Jnk,JUN,Nfat (family),NFkB (complex),NFKB1,NFKB2,NFKBIA,NR1I2,P38 MAPK,POU2F2,PPARG,PPARα-RXRα,REL,SMAD3,Sod,SP1,SRC (family),STAT1,STAT4,STAT5A ABCA3,ACAA1,AGA,ALDH7A1,ANGPT2,ANOS1,AOC1,B4GALT1,BIRC2,BIRC3,C1QTNF3,CALM1 (includes others),CD209,CEBPD,CR1,Cyp2d22,CYP39A1,EMILIN2,FGL1,FLNC,FUT6,GNAO1,GSTM3,H2BC21,HSD3B2,IFI44,ITGB3,L1CAM,LITAF,LRP6,MMRN1,NCAN,PGK1,POLI,PTPRK,REG1A,SLC16A4,SOD3,SYT12,TMPRSS6,TNFSF14,TRAF3IP2 42 (36) 34 NFkB (complex) pilocarpine chemical drug 3 0.000 5.42E-04 2.17E-02 ACHE,Alpha catenin,Ap1,APP,CDKN1B,CDKN2A,CEBPA,CHRM5,CNR1,COP1,CTNNB1,EGFR,EIF4E,ERK,ERK1/2,ETS2,FOS,GSK3B,IGF1,IL10,INSR,ITGB1,LGALS3,Muscarinic cholinergic receptor,MYB,P38 MAPK,p70 S6k,PDPK1,pilocarpine,PP2A,PRKAA,PRKCE,PRMT1,PSEN1,RB1,RXRA,S100A9,TCF7L2,TSC1,TSC2,TWIST1,VDR ACAA1,ADGRG6,AGA,ANGPT2,ANGPTL3,ANK1,AOC1,ATL2,BCHE,C1QTNF3,CALM1 (includes others),CEBPD,CHRNB3,CLPB,CR1,CUBN,EMX2,FAM111A,FAT4,FCGBP,IFI44,ITGB3,KIFC1,KMT5A,L1CAM,LRP4,LRP5,MAPK4,MEGF10,MKX,MMRN1,NLGN2,NUBP1,PGK1,PLIN2,POU3F3,PRKCSH,RAB11A,SLC5A7,SUSD2,SYT12,TNXB,TPPP3,TULP4 44 (42) 35 NPY ACHE,GRM5,N-acetyl-L-aspartic acid,SFRP1 KLRC4-KLRK1/KLRK1 transmembrane receptor 2 -1.964 5.58E-04 7.50E-03 Akt,AKT1,CTNNB1,KLRC4-KLRK1/KLRK1,MAPK1,MAPK8 ACAA1,AIMP2,B4GALT1,BIRC2,BIRC3,CEBPD,DGAT1,EMX2,FLNC,HNRNPM,IFI44,ITGB3,KIFC1,MATR3,PGK1,PLG,PLIN2,PTPRK,RRM2,SUSD2,TNFSF14 21 (6) 5 phytohemagglutinin,Ulbp IFNB1,prostaglandin E2,tacrolimus AKT1,LCP2,RXRA,TNFSF4 FASLG,VAV1 deoxycholate chemical - endogenous mammalian 3 -0.943 5.59E-04 4.73E-02 ABCB4,AGT,AHR,Akt,AKT1,Ap1,APP,ARNTL,clopidogrel,COP1,CREB1,CTNNB1,CXCL8,CYP2B6,CYP2E1,deoxycholate,EGFR,EIF2AK3,EIF4E,EPAS1,ERK1/2,ethanol,ETS2,FADD,FOS,HIF1A,HNF4A,HRAS,IGF1,IL10,IL1B,IL2,IL6,INSR,IRF3,JINK1/2,Jnk,Mapk,MITF,MYB,MYC,MYOD1,NEDD9,NFATC2,NFkB (complex),NGEF,NR1H4,NR1I2,P38 MAPK,PPARA,PRKD1,RAC1,RAF1,REL,RELA,RHOA,RICTOR,S100A9,SOX2,SPARC,STK11,TCF7L2,TNF,TNFSF11,TP73,TWIST1,VDR,WBP2 ACAA1,ADRM1,AGA,AIMP2,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,ATL2,B4GALT1,BBX,BCHE,BIRC3,C1QL1,CALM1 (includes others),CASP2,CD209,CEBPD,CGAS,CHRNB3,CLEC10A,CR1,CUBN,CYP39A1,EMX2,ETNK1,FAT4,FCGBP,FGL1,FRRS1,FUT6,GSTM3,HCRTR2,HNRNPM,HSD3B2,ITGB3,KIFC1,KMT5A,Lgals6,MATR3,MGAT4C,MKX,NANOS1,NLGN2,NUBP1,PGK1,PIF1,PLG,PLIN2,PNLIP,PTGIR,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SOD3,SSPOP,SUSD2,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TNXB,TPPP3,TRAF3IP2,TRIM2,TRIM56,TULP4 72 (68) 61 HNF4A AKT1,CASP3,ceramide,JINK1/2,NFkB (complex) CYP2B6 PDGFB growth factor 3 -1.432 5.66E-04 2.68E-02 26s Proteasome,AHR,Akt,AKT1,ALK,CASP3,CBL,CDKN1B,CEBPA,CITED2,CLOCK,CRYAB,DICER1,EIF2AK3,EIF4E,ELAVL1,ERK,ERK1/2,ETS2,FADD,FGFR2,FMR1,FOS,GRIN1,GSK3B,Hdac,HRAS,IGF1,IL10,IL6ST,INSR,Jnk,KLF6,L-tyrosine,LGALS3,MAP2K1/2,Mapk,MAPK1,MAPK3,Mek,MTOR,MYOD1,NFATC2,NGEF,NR1I3,NRAS,P38 MAPK,p85 (pik3r),PDGFB,PDPK1,PI3K (complex),PPARGC1A,PTK,RAF1,RAS,REL,RICTOR,S100A9,SOX2,SPARC,TCF7L2,TGFB1,TNF,TNFSF11,TWIST1 ADGRG6,ADRM1,AGA,AIMP2,ANGPT2,ANK1,AOC1,ATL2,BBX,BCHE,C1QL1,CACHD1,CALML3,CASP2,CD209,CEBPD,CGAS,CLEC10A,CLPB,CR1,CUBN,CYP39A1,EMILIN2,ETNK1,FASN,FCGBP,FLNC,FRRS1,HNRNPM,IFI44,ITGB3,KMT5A,L1CAM,Lgals6,LRP4,LRP5,MAPK4,MATR3,MEGF10,MKX,MMRN1,NLGN2,NUBP1,PLG,PNLIP,PRKCSH,PTPRK,RAB11A,RRM2,RSL24D1,SCARF1,SLC16A7,SVEP1,SYCE2,TENM3,TNFSF14,TRIM2,TRIM56,VPS25 59 (65) 52 8-bromo-cAMP,carbon tetrachloride,cocaine,Complement,DSCAM,EPAS1,GABARAP,GABARAPL1,GABARAPL2,PIK3CA,ZFTA-RELA ENG,MAP3K7,RXRA,TINCR AKT1,Ca2+,FGF7,p85 (pik3r),PDGFRA,RHOG CASP3,CNN1,FOXO4,mir-145 MIR17HG other 1 -0.816 5.75E-04 1.90E-03 MIR17HG BBX,CELSR1,LRP4,LRP6,PTK7,PTPRK 6 (1) 1 iodine CCNE1,MDFI ATP7A,DAB2IP,FZD4,HOXB5,KIT,LRP6,PDGFRA,RGMA,Sik1,WNT5A 3-methyladenine chemical toxicant 3 Activated 2.292 5.76E-04 2.95E-02 26s Proteasome,3-methyladenine,ACHE,AHR,Akt,AKT1,AMPK,APP,beta-estradiol,CASP3,CASP8,CASP9,CDK1,CFTR,CREB1,DICER1,DLX5,ELAVL1,ESR2,FMR1,GABARAPL2,HRAS,IGF1,IL1B,IL6,INSR,IRF3,MITF,MLXIPL,MYB,MYOD1,NFATC2,NFkB (complex),NFKB2,NGEF,NR1I2,NRAS,P38 MAPK,p70 S6k,PDPK1,PI3K (complex),PPARA,PPARGC1A,RB1,RELA,RICTOR,RPS6KB1,S100A9,SIRT1,SOX2,STING1,TBK1,TWIST1 ADRM1,AIMP2,ALDH7A1,ANGPT2,ANK1,ANOS1,ATL2,B4GALT1,BBX,BCHE,C1QL1,C1QTNF3,CACHD1,CALCRL,CELSR1,CGAS,CUBN,CYP39A1,EMILIN2,FAT4,FCGBP,FGL1,H2BC21,HCRTR2,HNRNPM,ITGB3,L1CAM,Lgals6,LRP4,LRP5,MAPK4,MATR3,MEGF10,MEGF11,MGAT4C,PIF1,PLG,POU3F3,RAB11A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC5A7,SOD3,SVEP1,SYCE2,TENM3,TKFC,TNFSF14,TNR,TPPP3,TRAF3IP2,VPS25 55 (53) 42 CASP3,caspase,NFkB (complex) HMOX1,IFNB1,leukotriene B4,prostaglandin E2,RPS6KB1 NTSR2 G-protein coupled receptor 3 -1.500 5.78E-04 3.77E-02 ACHE,Akt,Alpha catenin,Ap1,APP,AR,CDKN1B,COP1,CREB1,CTNNB1,CYP19A1,EIF4E,ERK1/2,ESR1,ESR2,ETS2,FADD,FOS,GRIN3A,HIF1A,HRAS,IGF1,IL10,IRF3,Jnk,KRT8,MAPT,MITF,MYB,MYC,NEDD9,NFkB (complex),NGEF,NR1I3,NTSR2,P38 MAPK,PGR,PKD1,PPARA,PPARGC1A,RAF1,RB1,RICTOR,RUNX3,RXRA,S100A9,SNCA,SRC,STAT5B,STK11,TNF,TWIST1,Vegf,WBP2,WWOX ADRM1,AIMP2,ALDH7A1,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ASPG,ATL2,BCHE,BIRC2,BIRC3,C1QTNF3,CALM1 (includes others),CD209,CEBPD,CHAC1,CLEC10A,CLPB,CR1,Cyp2d22,CYP39A1,EMILIN2,ETNK1,FAT4,FCGBP,GSTM3,HCRTR2,ITGB3,L1CAM,MAPK4,MEGF10,MEGF11,MGAT4C,MKX,NLGN2,NUBP1,PGK1,PIF1,PLG,REG1A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SUSD2,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TPPP3,TRIM2,TRIM3,TRIM56,TRPM2,TULP4 64 (55) 54 SFRP1 transmembrane receptor 2 0.229 5.84E-04 6.20E-03 CTNNB1,ERK,Jnk,JUN,SFRP1,SMAD3 ACAA1,ADGRG6,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,EMX2,FASN,ITGB3,KIFC1,L1CAM,PGK1,PLG,PLIN2,POLI,PTPRK,SUSD2 19 (6) 6 ceramide,DSCAM,FANCC,SALL4 8-bromo-cAMP,pilocarpine,ZEB2 Collagen type II,KRT18 CASP3,SCD ZMYND11 transcription regulator 0.000 3 -0.745 5.84E-04 4.88E-02 AHR,Ap1,CEBPA,CSF2,CXCL8,estrogen receptor,HIF1A,HNF4A,IL6,IRF3,JUN,NFkB (complex),NFkB (family),NFKBIA,NR1I2,POU2F2,PPARG,PPARα-RXRα,REL,SMAD3,STAT1,STAT4,STAT5A,TP53,ZMYND11 ABCA3,ACAA1,AGA,ALDH7A1,ANGPT2,ANOS1,AOC1,B4GALT1,BIRC2,BIRC3,CALCRL,CALM1 (includes others),CEBPD,CELSR1,CLEC10A,CR1,CSMD3,Cyp2d22,CYP39A1,EMILIN2,FGL1,FLNC,FUT6,GLB1,GSTM3,H2BC21,HSD3B2,IFI44,KIFC1,L1CAM,LITAF,LRP6,MMRN1,NCAN,PGK1,POLI,PPP1CA,PTPRK,REG1A,RRM2,SLC16A4,SOD3,SYT12,TMPRSS6,TSG101 45 (25) 24 NFkB (complex) NTN1 growth factor 0.000 3 -0.849 5.85E-04 2.64E-02 26s Proteasome,Alpha catenin,APP,ATF4,CASP3,CDC42,Creb,CREB1,DICER1,DSCAM,ERK1/2,ETS2,FADD,FOS,FYN,HIF1A,HOXA10,HRAS,IL10,Jnk,KRT8,MAPT,MITF,MYC,Nos,NR1I3,NRAS,NTN1,PAK1,PAK2,PGR,PLC gamma,PPARA,PPARGC1A,PTPN6,PTPRJ,RAC1,RAF1,RAPGEF3,RB1,RHOA,RICTOR,RXRA,SNCA,STK11,TCF7L2,TNF,TWIST1 ADRM1,ANGPT2,ANGPTL3,AOC1,ASPG,BBX,BCHE,BIRC2,BIRC3,C1QTNF3,CD209,CHAC1,CLEC10A,CR1,CYP39A1,DPY19L3,EMILIN2,ETNK1,FAT4,GSTM3,ITGB3,KMT5A,L1CAM,LRP5,MAPK4,MEGF11,MGAT4C,MKX,NLGN2,NUBP1,PIF1,PLG,POU3F3,REG1A,RRM2,RSL24D1,SERINC2,SLC16A4,SLC16A7,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNR,TPPP3,TRIM3,TRIM56,VPS25,WRN 50 (48) 37 DSCAM,PLC gamma,RAPGEF3 CASP3,leukotriene B4,prostaglandin E2 CYP2B6 enzyme 3 -0.781 5.98E-04 4.37E-02 4-methylnitrosoamino-1-(3-pyridinyl)-1-butanone,ABCC4,ACHE,aflatoxin B1,AKT1,BCL2,clopidogrel,Creb,cyclophosphamide,CYP2B6,ERK1/2,ESR2,Jnk,MAPK1,MAPK3,MAPK9,MDM2,MYC,NFkB (complex),NR1I2,PDPK1,Vegf ABCA3,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,CALCRL,CALM1 (includes others),CD209,CELSR1,CHAC1,CLEC10A,CYP39A1,DPY19L3,DUT,EMX2,FASN,FLNC,GLB1,GSTM3,H2BC21,HNRNPM,HSD3B2,ITGB3,KIFC1,KRT8,LGMN,MAPK4,MATR3,MEGF10,NANOS1,PGK1,PLG,PLIN2,PTPRK,RAB11A,RRP12,SLC16A7,SLC5A7,SNAP25,TSG101 41 (22) 20 8-bromo-cAMP,alpha-estradiol,amitriptyline,bergamottin,CASR,cerivastatin,CREB3L3,HNF4A,indomethacin,nifedipine,pentobarbital,PPARD,PRKAA1,roscovitine deoxycholate,PPARA Pak group 3 -1.050 5.99E-04 3.83E-02 AHR,Ap1,APP,CDKN1B,CEBPA,COP1,CREB1,CTNNB1,CXCL8,EIF4E,ERK,ERK1/2,ETS2,FADD,FOS,HIF1A,HNF4A,HRAS,IGF1,IL10,IL1B,IL6,IRF3,Jnk,MAP2K1,MAP2K1/2,MAP2K4,MAP3K1,MITF,MYB,MYO6,MYOD1,NFATC2,NFkB (complex),NFKB2,P38 MAPK,Pak,PAK1,PAK2,PAK3,PPARA,PPARGC1A,RAC1,RAF1,RB1,REL,RICTOR,RXRA,S100A9,SIRT1,STK11,TCF7L2,TNF,TWIST1 ADGRG6,AGA,ALDH7A1,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ATL2,B4GALT1,BBX,BCHE,BIRC2,BIRC3,C1QTNF3,CALM1 (includes others),CD209,CEBPD,CLEC10A,CLPB,CR1,ETNK1,FAT4,FCGBP,FGL1,FUT6,HCRTR2,ITGB3,KMT5A,Lgals6,MAPK4,MEGF10,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PIF1,PLG,POU3F3,RRM2,RSL24D1,SERINC2,SLC16A4,SLC16A7,SOD3,SUSD2,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNR,TPPP3,TRAF3IP2,TRIM56,TULP4,WRN 58 (54) 49 CDH5,DSCAM,G protein,VAV1 TNFAIP8L2 NFkB (complex) Cofilin,MDM2 FSTL1 other 0.000 3 -1.750 6.06E-04 4.05E-02 Akt,AKT1,AMPK,Ap1,APP,AR,CDKN1B,CEBPA,COP1,CREB1,CTNNB1,CYP19A1,EIF2AK3,EIF4E,ELAVL1,ERK,ESR1,ETS2,FADD,FOS,FSTL1,HIF1A,HNF4A,HRAS,IGF1,INSR,IRF3,Jnk,KRT8,MAPT,MITF,MLXIPL,MYB,MYC,MYCN,NFATC2,NFkB (complex),NFKBIA,NGEF,nitric oxide,NOS3,P38 MAPK,PPARA,PPARGC1A,PRKAA1,RICTOR,S100A9,SIRT1,SOX2,SPARC,STK11,TNF,TNFSF11,TWIST1,Vegf,WBP2,WNT3A ADGRG6,ADRM1,AIMP2,ALDH7A1,ANK1,ANOS1,ASPG,ATL2,BBX,BCHE,BIRC2,BIRC3,C1QL1,CACHD1,CALM1 (includes others),CD209,CEBPD,CLEC10A,CLPB,Cyp2d22,EMILIN2,ETNK1,FAT4,FCGBP,FRRS1,FUT6,HCRTR2,HNRNPM,ITGB3,L1CAM,LITAF,LRP4,LRP6,MATR3,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PIF1,PLG,PNLIP,REG1A,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SOD3,SUSD2,SVEP1,SYT12,TENM3,THSD4,TKFC,TMPRSS6,TNFSF14,TNXB,TPPP3,TRIM2,TRIM56,TRPM2,TULP4 64 (57) 56 ESR2 RXRA LRP6,Na+,K+ -ATPase,WNT3A tosylphenylalanyl chloromethyl ketone chemical - protease inhibitor 3 -0.283 6.06E-04 3.39E-02 26s Proteasome,AHR,Akt,AKT1,ALDH3A1,BCL2,CASP3,DICER1,DLX5,ERK1/2,FMR1,HMOX1,HNF4A,HRAS,IL1B,IL6,IRF3,MYOD1,NFATC2,NFkB (complex),NFKB1,NFKB2,NFKBIA,NGEF,NR1I2,NR1I3,PGR,PPARA,PPARGC1A,RAF1,RELA,RICTOR,RPS6KB1,RXRA,SOX2,SPARC,TNFSF11,tosylphenylalanyl chloromethyl ketone,TWIST1 ADRM1,AIMP2,ALDH7A1,ANGPT2,ANGPTL3,ANOS1,AOC1,B4GALT1,BBX,BIRC2,BIRC3,C1QL1,C1QTNF3,CD209,CEBPD,CYP39A1,FASN,FAT4,FCGBP,FGL1,FRRS1,FUT6,GNAO1,GSTM3,HNRNPM,KRT8,L1CAM,Lgals6,LITAF,LRP4,LRP5,MATR3,NCAN,PLG,POU3F3,REG1A,RRM2,RSL24D1,SCARF1,SLC16A7,SNAP25,SOD3,SVEP1,SYCE2,SYT12,TENM3,TNFSF14,TNR,TRAF3IP2,TRIM2 50 (39) 35 AKT1,ALDH3A1,CASP3,NFkB (complex),RPS6KB1 Trolox C chemical drug 3 0.832 6.07E-04 1.60E-02 26s Proteasome,ACHE,Akt,AKT1,APP,AR,CASP3,CEBPA,CFTR,COP1,CREB1,DICER1,DLX5,EIF2AK3,EIF4E,ERK1/2,ESR2,ETS2,FOS,GSK3B,HNF4A,HRAS,IGF1,IL10,KLF6,LGALS3,MAPK8,MITF,MYB,MYC,NEDD9,NFATC2,NGEF,NR1I3,P38 MAPK,PAWR,PDPK1,PLC,PRKAA,PRKCE,PTK2,RAC1,RAF1,RICTOR,S100A9,SIRT1,SOX2,SPARC,TCF7L2,TGM2,TNFSF11,Trolox C,TSC1 ADRM1,AGA,AIMP2,ANGPT2,ANK1,AOC1,ATL2,B4GALT1,BBX,BCHE,C1QL1,CEBPD,CHRNB3,CR1,CUBN,Cyp2d22,CYP39A1,DGAT1,FRRS1,FUT6,HCRTR2,HNRNPM,ITGB3,KMT5A,L1CAM,LRP4,LRP5,MATR3,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PIF1,PNLIP,POU3F3,PRKCSH,RAB11A,RRM2,RRP12,RSL24D1,SCARF1,SLC16A7,SLC5A7,SYT12,TENM3,THSD4,TNFSF14,TNR,TPPP3,TRIM2,TULP4 52 (53) 46 AKT1,Ca2+,CASP3,CCL3L3,radical GRK2 kinase 2 0.600 6.14E-04 1.51E-02 ADRB2,Akt,AKT1,CAV1,ERK,ERK1/2,GRK2,Jnk,MAPK8,MAPT,P38 MAPK,PIK3CG,SMAD3,SNCA,SRC ADGRG6,AIMP2,ANK1,AOC1,ASPG,B4GALT1,BIRC2,BIRC3,CD209,CHAC1,CLEC10A,FASN,HNRNPM,ITGB3,KRT8,L1CAM,LRP6,MATR3,MEGF11,PGK1,PLG,PTPRK,RRM2,TNFSF14,TRIM3 25 (15) 14 BDKRB2,CHRM2,PIK3CG,SSTR5 AKT1,Ca2+,CHRM1,IRS1,OPRK1 Stat5b dimer complex 3 -1.715 6.15E-04 2.33E-02 ABCB4,AKT1,Ap1,CEBPA,CYP19A1,EGFR,ERK1/2,HNF4A,JUN,MMP9,P38 MAPK,PPARA,PPARG,RB1,SMAD4,STAT5B,Stat5b dimer,TERT ABCA3,ACAA1,ANK1,AOC1,ASPG,BIRC3,CALCRL,CALM1 (includes others),CASP2,CEBPD,CELSR1,CGAS,CYP39A1,DGAT1,EMX2,FASN,FUT6,GLB1,GSTM3,H2BC21,HNRNPM,HSD3B2,IFI44,L1CAM,LITAF,MAPK4,MATR3,MMRN1,PLIN2,POLI,PTPRK,RRM2,SERINC2,TNXB 34 (18) 17 CISH CXCL10 cytokine 3 -1.511 6.17E-04 1.59E-02 26s Proteasome,Akt,AKT1,calpain,CFTR,CHRNA7,CITED2,CREB1,CXCL10,CXCL8,DICER1,ELAVL1,ETS2,FADD,GLI1,HIF1A,HNF4A,HRAS,IL10,Jnk,KRT8,MAPK1,Mek,MITF,MMP9,MYOD1,NFATC2,NGEF,NRAS,PDPK1,PI3K (complex),Pka,PPARA,PPARD,PPARGC1A,PTK2B,RAF1,REL,RHOA,RICTOR,Rsk,SIRT1,SNCA,SOX2,SPARC,SREBF2,STAT5B,STK11,TCF7L2,TGFB1,TNFSF11 ADRM1,AGA,AIMP2,BBX,BIRC2,C1QL1,C1QTNF3,CACHD1,CALML3,CASP2,CD209,CEBPD,CHAC1,CHRNA10,CLEC10A,CR1,CUBN,EMILIN2,ETNK1,FASN,FLNC,FRRS1,FUT6,HCRTR2,HNRNPM,IFI44,ITGB3,KMT5A,Lgals6,LRP4,LRP5,MATR3,MEGF11,MGAT4C,MKX,MMRN1,PIF1,PTPRK,RAB11A,REG1A,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SVEP1,TENM3,TMPRSS6,TNFSF14,TRIM2,TRIM3,VPS25 53 (51) 43 [D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin,arginine,CAMP,carbon tetrachloride,CASR,CDKN2A,CRKL,D-fructose,EBF1,FASLG,IFNB1,IL27,irinotecan,LIF,Map3k7,MAP3K7,MAPK7,MOG,NFkB (complex),Pam3-Cys,phospholipid,phytohemagglutinin,PIK3R2,RPS6KB1,RPS6KB2,S100A9,SAA1,TERT,TIRAP,trabectedin,WNT3A,WNT5A,ZFTA-RELA caffeic acid phenethyl ester,CISH,Ck2 alpha,GPS2,GW3965,HMOX1,IgG,Irgm1,MARCHF2,NR5A2,PIK3CG,POU5F1,prednisolone,prostaglandin E2,quercetin,RABGEF1,RXRA,SATB2,SCD,SOCS3,tacrolimus,USP18,USP19 Ca2+,SAA CNN1 other 3 Inhibited -2.343 6.19E-04 4.12E-02 Akt,AKT1,CDK2,CHUK,CNN1,CREB1,CTNNB1,CYP1A2,ERK,ERK1/2,FGFR2,Histone h3,HMOX1,HNF1A,HNF4A,IKBKB,INSR,MAPK1,MAPK8,NFKB1,NFKBIA,P38 MAPK,PRKCE,RAF1,STAT3 ACAA1,AIMP2,ANGPT2,ANGPTL3,ANK1,AOC1,BIRC3,CACHD1,CD209,CHRNB3,CUBN,DGAT1,EMX2,FCGBP,FGL1,FLNC,FUT6,GNAO1,GSTM3,HNRNPM,HSD3B2,ITGB3,KIFC1,L1CAM,LITAF,MATR3,MGAT4C,NCAN,PGK1,PKD1L2,PLG,PLIN2,PTPRK,RRM2,SERINC2,SLC16A7,SNAP25,SUSD2,TENM3,TNFSF14,TRPM2 41 (25) 24 DETA-NONOate,DGCR8,forskolin,Notch INHA,KT5823,PDGFB,phosphate HNF4A varespladib methyl chemical drug 3 0.816 6.21E-04 8.20E-03 ACHE,ALOX5,clopidogrel,ERK,ERK1/2,Jnk,MAPK1,MAPK14,MAPK3,MAPK8,NFkB (complex),NR1H3,P38 MAPK,PLA2G10,PLA2G2A,PLA2G5,PON1,PROC,varespladib methyl ADGRG6,ALDH7A1,ANGPT2,ANGPTL3,ANK1,AOC1,ASPG,B4GALT1,BIRC3,CD209,CEBPD,CHAC1,CLEC10A,DGAT1,FASN,FLNC,IFI44,ITGB3,LRP6,NANOS1,PLG,PTPRK,SLC5A7,SOD3 24 (19) 15 GnRH-A chemical reagent 2 -0.655 6.23E-04 4.80E-03 ERK,GnRH-A,MAPK1,MAPK3,MAPK8,MAPK9,Mek,P38 MAPK,RB1 ADGRG6,ANGPT2,ANK1,B4GALT1,BIRC3,CALCRL,CASP2,CEBPD,CELSR1,DGAT1,FASN,FLNC,H2BC21,IFI44,ITGB3,KIFC1,MAPK4,PLIN2,PTPRK,RRM2,SOD3 21 (9) 9 ATF3,BTG2,CGB3 (includes others),LHB,MAP3K11,PPP1R15A,RRAD EIF2AK1,FANCC deoxycholate chemical - endogenous mammalian 2 -1.616 6.24E-04 2.14E-02 ABCB4,Akt,AKT1,Ap1,CTNNB1,deoxycholate,EGFR,EIF2AK3,ERK1/2,JINK1/2,Jnk,NFkB (complex),NR1H4,NR1I2,P38 MAPK,RELA,TP73 ACAA1,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC3,CALM1 (includes others),CASP2,CD209,CEBPD,CGAS,CLEC10A,CYP39A1,EMX2,GSTM3,HNRNPM,HSD3B2,ITGB3,KIFC1,MATR3,PGK1,PLG,PLIN2,PNLIP,RRM2,SOD3,SUSD2,TNFSF14,TNXB 31 (17) 16 HNF4A AKT1,CASP3,ceramide,JINK1/2,NFkB (complex) CYP2B6 NPY other 2 -0.626 6.42E-04 9.80E-03 Akt,CaMKII,DDX41,ERK,ERK1/2,FOS,MAPK1,MAPK14,MAPK3,MAPK8,MAPT,NPY ADGRG6,AIMP2,ANGPT2,AOC1,ASPG,B4GALT1,BIRC2,BIRC3,CEBPD,CGAS,DGAT1,FASN,FLNC,HSD3B2,IFI44,ITGB3,KRT8,L1CAM,LRP6,NUBP1,PLG,PTPRK,TNFSF14 23 (12) 12 6-hydroxydopamine,amitriptyline,ASIP,etoposide,forskolin,GDF2,IL20,pilocarpine,RETN CNTF,cocaine,dorsomorphin,ESR2,INS,oleic acid,PPARD,RXRA,vildagliptin G protein,LPIN1 DDX41,levothyroxine,RAPGEF3 ST14 peptidase 0.000 2 -1.091 6.44E-04 5.60E-03 ERK1/2,HGF,NFkB (complex),NR1I2,P38 MAPK,PLAU,ST14 ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CALCRL,CALM1 (includes others),CASP2,CEBPD,CELSR1,CYP39A1,FASN,GSTM3,HSD3B2,ITGB3,L1CAM,LGMN,PLG,SOD3 21 (7) 6 Ca2+ IgG,thyroid hormone NFkB (complex) PARP16 enzyme -0.000 2 -1.890 6.46E-04 2.50E-03 EIF2AK3,ERN1,PARP16 BIRC2,BIRC3,CEBPD,DGAT1,FASN,PLIN2,PNLIP 7 (3) 2 tunicamycin ERN1 leukotriene B4 chemical - endogenous mammalian 3 -0.508 6.52E-04 3.44E-02 ABCB4,ACHE,Akt,APP,ATF4,CDKN2A,CITED2,CREB1,CXCL8,DLX5,EIF4E,ERK,ERK1/2,ESR2,ETS2,FADD,FOS,GLI1,HNF4A,HOXA10,HRAS,IFNGR1,IGF1,IKBKB,IKZF1,IL10,IL1B,IL6,IL6ST,INSR,IRS1,JAK2,Jnk,JUN,leukotriene B4,LTB4R,MAPK1,MDM2,MITF,MYB,MYC,MYCN,NFATC2,NFkB (complex),NFKB2,NFKBIA,NGEF,P38 MAPK,PAK2,PDPK1,PIK3CG,PPARA,Rac,RAC1,RAF1,RICTOR,S100A9,SIRT1,SYK,TCF7L2,TGFB1,TNF,TRPV1,WBP2,YES1 ACAA1,ADGRG6,ADRM1,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,ARL6IP4,ATL2,B4GALT1,BBX,BCHE,C1QTNF3,CALML3,CD209,CGAS,CHAC1,CLEC10A,CR1,DGAT1,ETNK1,FAM111A,FCGBP,FGL1,FLNC,FUT6,GSTM3,HCRTR2,HSD3B2,IFI44,KMT5A,L1CAM,LITAF,MGAT4C,MKX,NCAN,NLGN2,NUBP1,PIF1,PLIN2,POLI,POU3F3,PTPRK,RAB11A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A7,SLC5A7,SOD3,TENM3,THSD4,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM56,TULP4,WRN 62 (65) 56 CCL3L3,diosgenin,indomethacin,naproxen,phospholipid,PNPLA8 25-hydroxycholesterol,3-methyladenine,carbon monoxide,CISH,dibenzoylmethane,HNF4A,NTN1,oleic acid,propofol,SR 144528 Ca2+,IRS1,NFkB (complex),NOX4,PIK3CG,PPARA,YES1 SDCBP enzyme -0.000 2 -0.408 6.53E-04 1.14E-02 Akt,ERK1/2,Focal adhesion kinase,Jnk,MMP2,NFkB (complex),P38 MAPK,PTK2,SDCBP,SMAD3,SOX4,SRC,SRC (family),TGFBR1 AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CGAS,CHAC1,CLEC10A,DGAT1,FASN,ITGB3,KRT8,L1CAM,PGK1,PLG,PTPRK,RRM2,SOD3,TNFSF14 24 (14) 13 tacrolimus Cofilin,Focal adhesion kinase,NFkB (complex) TJP1 CTSA peptidase 1 -1.414 6.53E-04 8.00E-04 CTSA GLB1,SOD3 2 (1) 1 ciprofloxacin POU5F1 SOD3 tofogliflozin chemical drug 1 0.000 6.53E-04 1.40E-03 tofogliflozin DGAT1,FASN 2 (1) 1 SCD 14,15-epoxyeicosatrienoic acid chemical - endogenous mammalian 3 -0.962 6.53E-04 3.13E-02 14,15-epoxyeicosatrienoic acid,ABCB4,AHR,Akt,AKT1,APP,ARNTL,CDKN1B,CXCL8,DLX5,ERK,ETS2,FADD,FMR1,GSK3B,IL1B,IL2,IL6,Jnk,JUN,KLF6,LGALS3,Mapk,MYB,NFATC2,NFkB (complex),NFKB2,NFKBIA,NGEF,PDPK1,PPARA,PPARG,PPARGC1A,progesterone,RPS6KB1,SIRT1,SOX2,SPARC,TGFB1,TNF,TNFSF11 ACAA1,ADGRG6,ADRM1,AIMP2,ALDH7A1,B4GALT1,BBX,C1QL1,C1QTNF3,CALML3,CD209,CGAS,CLEC10A,CLPB,CR1,DGAT1,EMILIN2,ETNK1,FAM111A,FASN,FGL1,FRRS1,GSTM3,HCRTR2,HNRNPM,ITGB3,KRT8,L1CAM,LITAF,LRP4,MATR3,MKX,NCAN,PLIN2,POLI,POU3F3,PRKCSH,PTGIR,RAB11A,RRM2,SCARF1,SERINC2,SOD3,SVEP1,SYCE2,THSD4,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM2,TRIM56,TULP4 53 (41) 37 PNPLA8,POR AKT1,PIK3CG,PPARA,RPS6KB1 NFkB (complex),TNFRSF11A ketotifen chemical drug 3 1.257 6.66E-04 2.50E-02 26s Proteasome,Akt,AKT1,carbamazepine,CHRM1,CNR1,EGFR,EIF2AK3,HIF1A,HRH1,Jnk,ketotifen,MAPK1,MAPK14,MAPK3,MAPK8,MAPK9,mitomycin C,Nfat (family),Nos,NOS3,NR1I2,PDE4B,PDE8A,Pkc(s),RGS4,SCAP,SREBF2,STAT3 ADRM1,AIMP2,B4GALT1,CD209,CLEC10A,CYP39A1,DGAT1,FLNC,GSTM3,HNRNPM,HSD3B2,IFI44,KRT8,L1CAM,LRP4,LRP6,MATR3,MEGF6,PLG,PLIN2,PNLIP,PTPRK,REG1A,RRM2,SLC16A4,SOD3,SSPOP,TMPRSS6,TNFSF14,TNXB,TULP4 31 (29) 22 CHRM1 arginine chemical - endogenous mammalian 3 Inhibited -2.292 6.66E-04 3.69E-02 26s Proteasome,ACHE,AHR,Akt,AKT1,arginine,ATF4,CASP3,CAT,COP1,CXCL8,DICER1,DLX5,EIF2A,EIF2AK3,ESR2,ETS2,FMR1,FOS,GCG,HNF4A,HOXA10,HRAS,hydrogen peroxide,IFNGR1,IGF1,IGFBP1,IL10,IL1B,IL6,IL6ST,IRF3,JAK2,JUN,MYOD1,NFATC2,NFkB (complex),NFKB2,NGEF,Nos,NOS1,NR1I2,NRAS,PAWR,PDPK1,PI3K (complex),PPARGC1A,PTPRJ,RB1,REL,RICTOR,RPS6KB1,S6K1,SOX2,SPARC,STAT3,STAT5a/b,STAT5B,TGFB1,TNFSF11 ADRM1,AGA,AIMP2,ALDH7A1,ANGPT2,ANOS1,ARL6IP4,ATL2,B4GALT1,BBX,BCHE,C1QL1,C1QTNF3,CALCRL,CALML3,CD209,CELSR1,CHAC1,CR1,CYP39A1,FGL1,FRRS1,FUT6,H2BC21,HNRNPM,ITGB3,L1CAM,Lgals6,LRP5,MAPK4,MATR3,MKX,NUBP1,PGK1,PNLIP,POLI,POU3F3,PRKCSH,RAB11A,REG1A,RRP12,RSL24D1,SCARF1,SLC5A7,SOD3,SVEP1,SYCE2,SYT12,TENM3,THSD4,TNFSF14,TNR,TRAF3IP2,TRIM2,VPS25 55 (60) 48 AKT1,CASP3,CXCL10,Na+,K+ -ATPase,RPS6KB1,SCD Ecm,NFkB (complex),prostaglandin E2 benz[a]anthracene chemical toxicant 3 0.258 6.67E-04 6.70E-03 2-amino-1-methyl-6-phenylimidazo-4-5-b-pyridine,26s Proteasome,ALDH3A1,benz[a]anthracene,benzo(a)pyrene,CYP1A1,RB1 ADRM1,ANGPT2,BIRC2,BIRC3,CACHD1,CALCRL,CELSR1,FASN,GNAO1,GSTM3,H2BC21,MAPK4,RAB11A,RRM2,SOD3 15 (7) 5 ALDH3A1,GSTA1 NMI transcription regulator 2 -0.302 6.78E-04 2.40E-03 CDKN2A,Jnk,NMI BIRC3,CD209,CLEC10A,FAM111A,FASN,GLB1,ITGB3,KIFC1,PLG,RRM2,TSG101 11 (3) 2 benzo(a)pyrene,IFNB1,LIF miR-182-5p (and other miRNAs w/seed UUGGCAA) CDKN2A TERT taurocholic acid chemical - endogenous mammalian 3 -0.985 6.79E-04 3.78E-02 26s Proteasome,ABCB4,AGT,AHR,Akt,AKT1,AMPK,APP,AR,CASP3,CCK,CDKN1B,CREB1,CTNNB1,DICER1,DIO2,DIO3,EGFR,EIF4E,ELAVL1,ERK1/2,ESR1,ETS2,FADD,FOS,GLI1,HIF1A,HNF4A,IL10,Jnk,KRT8,MAPK8,Mek,MITF,MLXIPL,MYOD1,NEDD9,NFATC2,NGEF,NR1H4,NR1I3,NRAS,PDPK1,PI3K (complex),PRKCE,REL,RELA,RICTOR,SIRT1,SLCO1C1,SMARCA4,SOX2,SPARC,STAT5B,STK11,taurocholic acid,TCF7L2,TNF,TNFSF11,TP73,TWIST1,WBP2 ADAMTS16,ADRM1,AGA,AIMP2,ANGPT2,AOC1,B4GALT1,BBX,BIRC3,C1QL1,C1QTNF3,CACHD1,CD209,CEBPD,CGAS,CHRNB3,CLEC10A,CLPB,CR1,Cyp2d22,CYP39A1,DGAT1,DUT,ETNK1,FAT4,FRRS1,FUT6,HCRTR2,HNRNPM,ITGB3,KMT5A,L1CAM,Lgals6,LRP4,LRP5,MATR3,MGAT4C,MKX,NLGN2,NUBP1,PGK1,PIF1,PLG,RAB11A,REG1A,RRM2,RSL24D1,SCARF1,SLC16A4,SOD3,SSPOP,SUSD2,SYCE2,SYT12,THSD4,TKFC,TMPRSS6,TNFSF14,TNXB,TPPP3,TRIM2,TRIM36,TRIM56,TRPM2,TULP4,VPS25 66 (62) 56 NR5A2,TFAM AKT1,ATF3,bile acid,PPARA,prostaglandin E2 CASP3 brivanib alaninate chemical drug 3 1.667 6.79E-04 3.45E-02 Akt,AKT1,brivanib alaninate,Creb,CREB1,ERK,ERK1/2,FGFR,FGFR2,FGFR4,ITGAV,ITGB3,KDR,MAPK1,Mek,MYBL2,NOS3,NR3C1,P38 MAPK,Pkc(s),PPARG,PTK2,PTPN11,RAS,RUNX2,SRC,SRC (family),STAT,STAT3,STAT5A,Vegf,Vegf Receptor ABCA3,ACAA1,ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,CALCRL,CALM1 (includes others),CASP2,CD209,CEBPD,CELSR1,CUBN,DGAT1,DPY19L3,FLNC,HNRNPM,HSD3B2,ITGB3,KRT8,L1CAM,LITAF,MATR3,MGAT4C,PGK1,PLG,PLIN2,PTPRK,RRM2,SERINC2,SOD3,TENM3,TNFSF14 36 (32) 29 sorbitol chemical - endogenous mammalian 2 0.316 6.97E-04 4.89E-02 Akt,AKT1,Ap1,APP,EGFR,ERK,ERK1/2,Jnk,JUN,MAPK1,MAPK14,MAPK3,MAPK8,MAPK9,MKNK1,NFkB (complex),NFKBIA,P38 MAPK,PRKAA1,sorbitol,TP53 ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,CALCRL,CALM1 (includes others),CASP2,CD209,CELSR1,CLEC10A,CSMD3,DGAT1,DUT,FLNC,GLB1,GNAO1,GSTM3,H2BC21,HNRNPM,HSD3B2,ITGB3,KIFC1,L1CAM,LRP6,MATR3,NCAN,PLIN2,POLI,POU3F3,PPP1CA,PTPRK,SNAP25,THSD4,TNFSF14,TNXB,TPPP3,TSG101 40 (21) 20 SLC2A1 CASP3,Focal adhesion kinase,HSPB1,MAP3K11,Map3k7,MAP3K7,MAPK7,NFkB (complex),PRKAA1,Sapk,TAOK2 AKT1 FGFR4 kinase 0.000 2 -1.213 6.97E-04 5.20E-03 Akt,ERK,ERK1/2,FGFR4,JINK1/2,Jnk,SRC ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FASN,ITGB3,L1CAM,PGK1,PLG,RRM2,TNFSF14 17 (7) 7 carbon tetrachloride,FGF19 INHA,PD173074 JINK1/2 bile acid,CDH2 25-hydroxycholesterol chemical reagent 2 0.258 7.06E-04 3.00E-03 25-hydroxycholesterol,Akt,CETP,NR1H2,NR5A1,PRKCE,SREBF2 AIMP2,ANGPT2,ANGPTL3,BIRC2,BIRC3,CHAC1,CHRNB3,FASN,HSD3B2,L1CAM,PLG,PLIN2,REG1A,RRM2,TNFSF14 15 (7) 7 ATF3,sphingomyelin ACSL1,HMOX1,leukotriene B4,SCD TSPYL2 other 2 -0.632 7.08E-04 2.20E-03 CDK2,ERK1/2,MDM2,TSPYL2 ANGPT2,AOC1,BIRC2,BIRC3,CASP2,H2BC21,ITGB3,SNAP25,TSG101,WRN 10 (4) 3 camptothecin MDM2 CGP 74514A chemical drug 3 0.000 7.19E-04 2.66E-02 ACHE,Akt,ATF4,CASP3,CASP8,CGP 74514A,COP1,DICER1,DLX5,EIF4E,ERK1/2,ESR2,ETS2,FMR1,FOXO1,Gsk3,HIF1A,IGF1,IL10,IL1B,MAFB,MLXIPL,MYB,MYOD1,NFATC2,NGEF,P38 MAPK,RB1,RICTOR,RPS6KB1,S100A9,SIRT1,STK11,TNF AIMP2,ANGPT2,ANGPTL3,ANK1,AOC1,ATL2,BBX,BCHE,BIRC2,BIRC3,CALCRL,CASP2,CEBPD,CELSR1,CHAC1,CR1,FASN,H2BC21,HCRTR2,L1CAM,Lgals6,LRP5,MAPK4,MKX,NLGN2,PLG,POU3F3,PTGIR,RRM2,RRP12,RSL24D1,SCARF1,SLC16A4,SLC5A7,SYCE2,SYT12,THSD4,TKFC,TMPRSS6,TNFSF14,TNR,TRAF3IP2,TRIM56,TULP4 44 (34) 30 CASP3 RPS6KB1 ACSS2 enzyme 0.000 1 0.577 7.36E-04 1.50E-03 ACSS2 ACAA1,DGAT1,FASN 3 (1) 1 HNF4A,MAPK7,Srebp,sucrose 4-(2-aminoethyl)benzenesulfonylfluoride EHHADH,GPAM,SCD DYSF other 0.000 1 0.577 7.36E-04 2.40E-03 DYSF DGAT1,FASN,ITGB3 3 (1) 1 ammonium,TMPRSS2-ERG GPAT3,SCD LPCAT1 enzyme 0.000 2 1.890 7.37E-04 2.60E-03 EIF2AK3,ERN1,LPCAT1 BIRC2,BIRC3,CEBPD,DGAT1,FASN,PLIN2,PNLIP 7 (3) 2 FGF7 ERN1 SETD2 enzyme -0.000 2 0.000 7.55E-04 5.00E-03 CTNNB1,ERK,Histone h3,SETD2 ACAA1,ADGRG6,ANGPTL3,CEBPD,EMX2,FASN,ITGB3,KIFC1,L1CAM,PGK1,PLG,PLIN2,RRM2,SUSD2 14 (4) 4 Histone h2a CSNK1D,VEGFB CDH2,ENG,PDGFC,WNT5A OSI-930 chemical drug 3 1.521 7.68E-04 3.53E-02 Akt,AKT1,CREB1,ERK,ERK1/2,GAB2,GRB2,ITGAV,ITGB3,JAK,Jnk,KDR,KIT,MAPK1,MAPK8,Mek,MITF,NOS3,OSI-930,P38 MAPK,PI3K (complex),PTK2,PTPN11,RAF1,SRC,SRC (family),STAT,STAT3,STAT5A,Vegf ABCA3,ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CLEC10A,DGAT1,EMX2,FLNC,HNRNPM,HSD3B2,IFI44,ITGB3,KIFC1,L1CAM,LITAF,MATR3,MGAT4C,PGK1,PIF1,PLG,PTPRK,RRM2,SERINC2,SLC16A7,SOD3,TNFSF14 35 (30) 28 KIT MGAT5 enzyme -0.000 2 -0.243 7.73E-04 8.70E-03 CTNNB1,Focal adhesion kinase,MAPK1,MAPK3,MGAT5,PTK2,PTPN11 ABCA3,ACAA1,B4GALT1,BIRC2,BIRC3,EMX2,FASN,FLNC,IFI44,ITGB3,KIFC1,KRT8,L1CAM,PGK1,PLIN2,PTPRK,SUSD2 17 (7) 6 8-bromo-cAMP CDH2 Focal adhesion kinase RAP1A enzyme 2 -1.147 7.74E-04 8.80E-03 AKT1,CTNNB1,ITGB1,Jnk,P38 MAPK,RAF1,RAP1A ACAA1,ANK1,BIRC3,CD209,CEBPD,CLEC10A,EMX2,HNRNPM,KIFC1,L1CAM,LRP6,MATR3,PGK1,PLG,PLIN2,RRM2,SLC16A7,SUSD2,TNXB 19 (7) 6 forskolin,RAPGEF1,RAPGEF3 AKT1,MMP7 telmisartan chemical drug 3 -0.132 7.78E-04 3.57E-02 26s Proteasome,ABCB4,ACHE,AGT,AGTR1,Akt,AMPK,APP,CASP3,CFTR,CHRNA7,CNR1,CREB1,DICER1,EIF4E,ELAVL1,ERK1/2,ESR2,ETS2,FOS,GLI1,HRAS,IGF1,IL2,JUN,MDM2,MITF,MLXIPL,MYC,NFATC2,NGEF,NR1I3,NRAS,P38 MAPK,PAK2,Pka,PPARA,PPARD,PPARG,PPP3R1,PRKCE,progesterone,RAF1,S100A9,STAT5B,telmisartan,TGFB1 ABCA5,ACAA1,ADRM1,AIMP2,ANGPT2,ANK1,AOC1,ATL2,BBX,BCHE,BIRC3,C1QTNF3,CACHD1,CALML3,CEBPD,CGAS,CHRNA10,CHRNB3,CLEC10A,CR1,CUBN,CYP39A1,DGAT1,FAM111A,GSTM3,HSD3B2,ITGB3,L1CAM,LRP4,LRP5,MGAT4C,MKX,NLGN2,NUBP1,PIF1,PLG,PLIN2,PNLIP,POLI,PTGIR,REG1A,RRM2,RRP12,SCARF1,SERINC2,SLC16A7,SLC5A7,SOD3,SSPOP,SVEP1,TENM3,THSD4,TKFC,TNFSF14,TPPP3,VPS25,WRN 57 (47) 43 ACSL1,MAS1,NPHS1,PPARA,TFAM CASP3,NFkB (complex) cytochalasin B chemical toxicant 3 0.378 7.81E-04 3.96E-02 ACHE,Actin,Akt,Alpha catenin,Ap1,APP,AR,CDKN1B,CDKN2A,COP1,CREB1,CYP19A1,cytochalasin B,EIF4E,ERK1/2,ESR1,ESR2,ETS2,FADD,FGF2,FOS,GRIN3A,HGF,HIF1A,HMOX1,HRAS,IL10,IL6,IRF3,Jnk,MAPK1,MAPT,MITF,MYB,MYC,NEDD9,NFkB (complex),NGEF,NR1I3,P38 MAPK,PGR,Pld,PLG,PPARA,PPARGC1A,RAF1,RB1,RICTOR,RUNX3,RXRA,S100A9,SNCA,SRC,STAT5B,Tgf beta,TGFB1,TWIST1,Vegf,WBP2,WWOX ADRM1,AIMP2,ALDH7A1,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ASPG,BCHE,BIRC2,BIRC3,C1QTNF3,CALM1 (includes others),CALML3,CEBPD,CHAC1,CLEC10A,CLPB,CR1,Cyp2d22,CYP39A1,EMILIN2,ETNK1,FAM111A,FCGBP,FGL1,FLNC,GSTM3,HCRTR2,IFI44,ITGB3,L1CAM,LRP5,MAPK4,MEGF10,MEGF11,MGAT4C,MKX,NLGN2,NUBP1,PGK1,PIF1,PLG,PLIN2,PTPRK,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A7,SLC5A7,SVEP1,SYT12,TENM3,TMPRSS6,TNFSF14,TPPP3,TRIM2,TRIM3,TRPM2,TULP4 63 (60) 56 FPR1 PTTG1 SEMA3B other 2 0.243 7.83E-04 6.70E-03 Akt,GSK3B,MDM2,PDPK1,PTEN,SEMA3B ACAA1,AIMP2,ANGPT2,BIRC3,CALCRL,CASP2,CELSR1,FASN,H2BC21,L1CAM,PGK1,PLG,RAB11A,RRM2,TNFSF14,TSG101,WRN 17 (6) 5 GDF2 S100A9 MDM2 DBH-AS1 other 2 -0.500 7.85E-04 4.70E-03 CTNNB1,DBH-AS1,ERK,Jnk,P38 MAPK ACAA1,ADGRG6,ANK1,BIRC3,CD209,CEBPD,CLEC10A,EMX2,FASN,ITGB3,KIFC1,L1CAM,PGK1,PLG,PLIN2,SUSD2 16 (5) 4 CCNE1,SLC2A1 CDKN2A PIK3CD kinase 0.000 3 0.674 7.90E-04 3.98E-02 26s Proteasome,Akt,AKT1,APP,BTK,CDKN1B,CDKN2A,CSF1R,DLX5,EIF2AK3,EIF4E,ERK,ESR1,ETS2,FOS,FOXO3,GSK3B,HRAS,IKZF1,IL10,IL2,INSR,IRF3,KLF6,LGALS3,NEDD9,NFKB2,NGEF,NRAS,p70 S6k,PDPK1,phosphatidylinositol-3,4,5-triphosphate,PI3K (complex),PIK3CD,PIK3R1,PIK3R2,PLCG2,PPARGC1A,PRKCE,PTEN,PTK2,Rab5,REL,RGS4,SOX2,SPARC,SREBF2,STAT5B,TNFSF11,TWIST1 ACAA1,ADGRG6,ADRM1,AGA,AIMP2,ANGPT2,ANOS1,C1QL1,C1QTNF3,CALCRL,CEBPD,CELSR1,CGAS,CHRNB3,CLPB,CR1,CYP39A1,DUT,EMILIN2,FAM111A,FASN,FAT4,FCGBP,FRRS1,HNRNPM,ITGB3,L1CAM,LRP4,MATR3,MEGF6,MKX,MMRN1,NLGN2,NUBP1,PGK1,PLG,PNLIP,POU3F3,PRKCSH,PTGIR,RAB11A,REG1A,RRM2,SCARF1,SSPOP,SVEP1,TENM3,THSD4,TNFSF14,TNR,TPPP3,TRIM2,TRPM2,TULP4,VPS25 55 (50) 39 cytokine receptor,EBF1,G Protein I,INHA,TRIB1,tyrosine kinase IC87114,PIK3CA,PIK3CG AKT1,CCND2,CCNE1,phosphatidylinositol 3,4-diphosphate,Rab5 CD19 transmembrane receptor 2 -0.730 8.00E-04 2.19E-02 Akt,AKT1,CD19,ERK,ERK1/2,Jnk,MAP2K1,MAPK1,MAPK8,MAPK9,MYC,p85 (pik3r),PI3K (complex),PI3K (family),STAT1 ABCA3,ADGRG6,AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CASP2,CD209,CLEC10A,DGAT1,EMX2,FASN,FLNC,HNRNPM,IFI44,ITGB3,L1CAM,LGMN,MATR3,PGK1,PLG,PLIN2,PTPRK,RRM2,SLC16A7,SOD3,TNFSF14,WRN 30 (15) 14 EP300,WIPF1 AKT1,Ca2+,p85 (pik3r),VAV1 GAST other 2 Inhibited -2.137 8.01E-04 4.35E-02 Akt,AKT1,Ap1,Creb,CREB1,CTNNB1,EGFR,ERK,ERK1/2,Focal adhesion kinase,GAST,Jnk,JUN,MAPK1,MAPK14,MAPK3,MAPK8,P38 MAPK,PI3K (complex),PPARG,PRKCE,PTK2,RAF1,RELA,SP1,STAT3 ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC3,CALM1 (includes others),CD209,CHRNB3,CLEC10A,DGAT1,DPY19L3,EMX2,FLNC,HNRNPM,IFI44,ITGB3,KIFC1,KRT8,LITAF,LRP6,MATR3,MGAT4C,PGK1,PLG,PLIN2,POLI,PTPRK,REG1A,RRM2,SERINC2,SLC16A7,SNAP25,SUSD2,TNFSF14,TNXB 37 (26) 26 EP300,forskolin AKT1,ATF2,Focal adhesion kinase,HCFC1,iron,LOC102724428/SIK1,MAP3K11,MAPK7,MMP7,POR,PRKD2,PRKD3 CASP3,IL11 urea chemical - endogenous mammalian 2 -1.342 8.06E-04 9.40E-03 AKT1,ATM,ERK,ERK1/2,ITGB1,Jnk,MAPK1,MAPK3,P38 MAPK,PTK2,SRC,urea ADGRG6,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,FLNC,HNRNPM,IFI44,LRP6,MATR3,PGK1,PTPRK,RRM2,TNXB 20 (12) 11 HNF4A BDKRB2,L-triiodothyronine AKT1,INS quinidine chemical drug 3 1.480 8.13E-04 4.29E-02 2-amino-1-methyl-6-phenylimidazo-4-5-b-pyridine,ABCB4,ABCC4,acetaminophen,ACHE,ADRA1A,ADRA1B,ADRA1D,ADRA2A,ADRA2B,ADRA2C,Akt,AKT1,alpha-adrenergic receptor,benzo(a)pyrene,Calcineurin protein(s),CHRM1,CHRM2,CHRM3,CHRM5,clopidogrel,CNR1,CYP,CYP19A1,CYP1A1,CYP2C8,EGFR,ERK,ERK1/2,Jnk,KCND2,LEF1,MAPK1,MAPK14,MAPK8,MAPT,methimazole,Nfat (family),P glycoprotein,paclitaxel,Pkc(s),PRKCE,quinidine,RGS4,SCN5A,SRC,STAT3 ADGRG6,AIMP2,ALDH7A1,ANGPT2,AOC1,ASPG,BIRC2,CACHD1,CD209,CGAS,CHAC1,CHRNB3,CLEC10A,DGAT1,FLNC,GNAO1,GSTM3,HNRNPM,HSD3B2,IFI44,KRT8,LRP4,LRP6,MATR3,MEGF6,NANOS1,PGK1,PLG,PTPRK,RAB11A,RRM2,SLC5A7,SSPOP,SYT12,TNFSF14,TNXB,TSG101 37 (47) 30 ACHE,CHRM1,CHRM2 VEGFB growth factor 3 Inhibited -2.032 8.23E-04 4.35E-02 ACHE,Akt,Ap1,APP,AR,CDKN1B,CLOCK,COP1,CREB1,CTNNB1,CYP19A1,EGFR,EIF4E,ERK1/2,ESR1,ESR2,ETS2,FADD,FLT1,FOS,HIF1A,HIPK2,HRAS,IGF1,IL10,IRF3,ITGB1,Jnk,KRT8,MAPT,MITF,MYB,MYC,NGEF,NR1I3,P38 MAPK,PDPK1,PGR,PLA2G2A,PLA2G4A,PLD1,PPARA,PPARGC1A,PRKCE,PRKCG,RAF1,RB1,RICTOR,RXRA,S100A9,SNCA,SRC (family),STK11,TNF,TWIST1,Vegf,VEGFB AIMP2,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ASPG,ATL2,BCHE,BIRC2,BIRC3,CALM1 (includes others),CASP2,CD209,CEBPD,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,Cyp2d22,CYP39A1,EMILIN2,ETNK1,FAT4,GSTM3,ITGB3,L1CAM,MAPK4,MEGF10,MEGF11,MGAT4C,MKX,NLGN2,NUBP1,PIF1,PLG,RAB11A,REG1A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SLC5A7,SUSD2,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TNXB,TPPP3,TRIM3,TRIM56,TRPM2,TULP4,XPO7 62 (57) 53 SETD2,sildenafil CA4,DIO2,EHHADH,PLD1,SOD1 ATF3 mir-154 microRNA 2 0.500 8.28E-04 5.20E-03 Akt,CTNNB1,GSK3B,HMOX1,mir-154 ACAA1,AIMP2,ANGPT2,ANGPTL3,BIRC2,BIRC3,EMX2,FASN,ITGB3,KIFC1,L1CAM,PGK1,PLG,PLIN2,RRM2,SUSD2 16 (5) 4 cocaine,HNF4A dalfampridine,OIP5-AS1 MMP7 caspase,FZD4,HMOX1,KIT,PMP22 CDH5 other 2 -0.229 8.39E-04 8.00E-03 Akt,CDH5,CTNNB1,FOXO1,ITGB1 ACAA1,AIMP2,BIRC2,BIRC3,CASP2,CEBPD,EMX2,FASN,ITGB3,KIFC1,L1CAM,LRP6,PGK1,PLG,PLIN2,RRM2,SUSD2,TNFSF14,TNXB 19 (5) 4 ANGPT1,ENG,KU-55933,LIF,PD173074,PIK3CA,RAC2 ADAM10,FOXO4 Pak RYBP transcription regulator 3 0.200 8.53E-04 1.91E-02 Akt,CRK,EGFR,ENO1,ERK,ERK1/2,FSH,GABP,GABPA,H2AB3 (includes others),H2AZ1,Histone h2a,Jnk,LRP5,MAPK1,MAPK3,MAPK8,MET,P38 MAPK,RYBP,SETD2,SRC ADAMTS16,ADGRG6,AIMP2,ANGPT2,ANGPTL3,AOC1,B4GALT1,CD209,CEBPD,CHAC1,CLEC10A,DGAT1,FLNC,HSD3B2,IFI44,L1CAM,LRP6,MAPK4,PGK1,PTPRK,RRM2,SNAP25,SOD3,TNFSF14,TNXB 25 (22) 17 Histone h2a MAP3K11 kinase 2 -1.633 8.54E-04 1.41E-02 CHUK,CTNNB1,ERK,ERK1/2,IKBKB,Jnk,JUN,MAP2K1,MAP2K4,MAP3K11,MAPK1,MAPK14,MAPK8,MAPK9,P38 MAPK ACAA1,ADGRG6,ANGPT2,ANK1,AOC1,B4GALT1,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,EMX2,FLNC,IFI44,ITGB3,KIFC1,KRT8,L1CAM,LRP6,PGK1,PLG,POLI,PTPRK,SUSD2 24 (15) 14 6-hydroxydopamine,AKT1,camptothecin,ceramide,GAST,GnRH-A,MAP3K10,MAP4K4,sorbitol CASP3,MAP2K4/7,MMP7,RPS6KB1,Sapk HNF4A transcription regulator 0.000 2 -1.000 8.76E-04 1.25E-02 CTNNB1,CYP1A2,CYP7A1,HMOX1,HNF1A,HNF4A,NFkB (complex),STAT ACAA1,ALDH7A1,ANGPT2,ANGPTL3,B4GALT1,BIRC2,BIRC3,CACHD1,CEBPD,EMX2,FASN,FGL1,FUT6,GSTM3,ITGB3,KIFC1,L1CAM,PGK1,PKD1L2,PLG,PLIN2,SOD3,SUSD2,TNFSF14,TRPM2 25 (8) 8 CNN1,EP300 CDN1163,JINK1/2,LRP5,NR0B1 ACSL1,ACSS2,AHNAK,ATOX1,ATP7A,Ca2+,CIDEC,CYP2B6,G6PC3,GSTA1,HMOX1,LOC102724788/PRODH,mir-154,Mt,NOX4,SCP2,SOD1,TAT,urea BMP7,deoxycholate,leukotriene B4,miR-142-5p (and other miRNAs w/seed AUAAAGU),Mt3,PDK1,POR,SLC2A1 PDGFRA kinase -0.000 3 -1.172 8.77E-04 4.80E-02 26s Proteasome,AHR,Akt,AKT1,Ap1,APP,CBL,CDC42,CDKN1B,CREB1,EIF2AK3,EIF4E,ERK1/2,ESR1,ETS2,FOS,Hdac,HIF1A,HIPK2,HNF4A,HRAS,IL10,ITGAV,ITGB3,L-tyrosine,MAPK8,mir-21,MITF,MYC,NFATC2,NGEF,NRAS,PDGFRA,PGR,PI3K (complex),PLC gamma,PPARA,PPARGC1A,PRKCE,PTPN11,RAC1,RAF1,RAS,RICTOR,SIRT1,SNCA,SOX2,SPARC,SRC (family),STAT1,STAT3,STK11,TCF7L2,TGFB1,TNFSF11,TWIST1,Vegf ABCA3,ADRM1,AIMP2,ANGPT2,AOC1,BBX,BIRC2,BIRC3,C1QL1,CALM1 (includes others),CALML3,CASP2,CD209,CEBPD,CHAC1,CHRNB3,CLPB,CR1,DGAT1,EMILIN2,FAT4,FRRS1,FUT6,GSTM3,HCRTR2,HNRNPM,ITGB3,KMT5A,L1CAM,LRP4,MATR3,MEGF11,MGAT4C,MKX,NLGN2,NUBP1,PGK1,PIF1,PNLIP,RRM2,RSL24D1,SCARF1,SERINC2,SLC16A4,SLC16A7,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,TNR,TPPP3,TRIM2,TRIM3,TRPM2,TULP4,VPS25,XPO7 59 (57) 50 8-bromo-cAMP,ATF2,carbon tetrachloride,MAP2K2,PDGF-AA,PDGFB,PDGFC,POU5F1,tanespimycin acyclic retinoid,IFT20,mir-145,MIR17HG,PIK3CA,PRKAA1,SFRP2,Slfn1,WNT3A DAB2,PLC gamma BHLHE40 transcription regulator 2 1.069 8.78E-04 5.40E-03 Akt,BHLHE40 AIMP2,ALDH7A1,BIRC2,CALCRL,FASN,GSTM3,KRT8,L1CAM,PGK1,PLG,PLIN2,RRM2,SCARF1,TNFSF14 14 (2) 2 cocaine,deferoxamine,EPAS1,forskolin,IFNB1,Map3k7,quercetin,S100A9,SYVN1 ATF3,CASP3,CCR7,EXT1,FPR1,FRZB,GNAI3,HAS1,ITGA4,KDM3A,LCP2,LGALS3BP,LIF,LPAR1,MERTK,PLAC8,PROCR,RASGRP1,RGS16,SDC4,SLC2A1,SOCS3 KIT,KRT18,TFF2 UBR2 enzyme 3 0.302 8.87E-04 3.20E-03 AURKB,CASP1,FSH,H2AB3 (includes others),H2AZ1,Histone h2a,Inflammasome (Nalp1b, Asc, Casp1),MACROH2A1,SETD2,UBR2 ADAMTS16,ANGPTL3,ANK1,CHAC1,FASN,FLNC,HSD3B2,MAPK4,PLG,SLC16A7,SNAP25 11 (10) 8 Histone h2a DBP transcription regulator -0.000 3 1.029 8.93E-04 3.22E-02 ABCB4,Ap1,CEBPA,CYP19A1,DBP,ERK1/2,HNF4A,JUN,MMP2,MMP9,NFkB (complex),P38 MAPK,PPARA,PPARG,RB1,ROR,RORC,SMAD4,STAT5B,TERT ABCA3,ACAA1,ALDH7A1,ANK1,AOC1,ASPG,B4GALT1,CALCRL,CALM1 (includes others),CASP2,CEBPD,CELSR1,CGAS,CYP39A1,DGAT1,EMX2,FASN,FUT6,GLB1,GSTM3,H2BC21,HSD3B2,IFI44,L1CAM,LITAF,MAPK4,PGK1,PLG,PLIN2,POLI,PTPRK,RRM2,SERINC2,SOD3 34 (20) 18 Ca2+,L-triiodothyronine,NFkB (complex) HOXA10 PPARA GSTA1 enzyme 3 0.885 8.94E-04 4.79E-02 AKT1,CEBPA,COP1,Creb,EIF4E,FADD,FOS,GSTA1,HIF1A,IKBKB,IL2,Jnk,JUN,KRT8,MAPT,MYC,NFKBIA,PDPK1,Pkc(s),PPARA,PPARG,PPARGC1A,progesterone,RB1,RICTOR,RXRA,STAT5B,TGFB1,TNF,TWIST1 ACAA1,ADGRG6,ANGPTL3,ASPG,BIRC2,BIRC3,CALML3,CD209,CGAS,CLEC10A,CYP39A1,DGAT1,DPY19L3,EMILIN2,ETNK1,FAM111A,FASN,FAT4,FCGBP,GNAO1,H2BC21,HNRNPM,KRT8,LGMN,MAPK4,MATR3,MMRN1,NCAN,NLGN2,NUBP1,PLG,PLIN2,POLI,PTGIR,RAB11A,REG1A,RSL24D1,SERINC2,SLC16A4,SLC16A7,SVEP1,SYT12,TMPRSS6,TNR,TRIM56,WRN 46 (30) 29 benz[a]anthracene,beta-naphthoflavone,ceramide,HNF4A,IL20,isorhamnetin,NOX4,PRKAA1,quercetin benzo(a)pyrene,levothyroxine ZEB2 transcription regulator 1.440 2 -0.894 8.99E-04 8.20E-03 Akt,AKT1,ERK1/2,Jnk,Nfat (family),P38 MAPK,RB1,ZEB2 AIMP2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CALCRL,CD209,CEBPD,CELSR1,CLEC10A,FASN,H2BC21,HNRNPM,ITGB3,L1CAM,MAPK4,MATR3,PLG,TNFSF14 20 (8) 7 ammonium,GPI,PAK2,TMPRSS2-ERG 19,20-epoxydocosapentaenoic acid,Notch,PCGF2 AKT1,CCL3L3,CDH2 CASP3,CDKN2A,KRT18,MEOX2,SFRP1,TERT tosylphenylalanyl chloromethyl ketone chemical - protease inhibitor 2 1.043 9.08E-04 1.68E-02 Akt,AKT1,BCL2,ERK1/2,NFkB (complex),NFKB1,NFKBIA,RAF1,tosylphenylalanyl chloromethyl ketone AIMP2,ALDH7A1,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,FASN,GNAO1,HNRNPM,KRT8,L1CAM,LITAF,MATR3,NCAN,PLG,RRM2,SLC16A7,SNAP25,SOD3,TNFSF14 23 (9) 9 AKT1,ALDH3A1,CASP3,NFkB (complex),RPS6KB1 quinalphos chemical toxicant 3 0.688 9.19E-04 9.50E-03 ACE,ACHE,AGT,Gsk3,GST,GSTK1,GSTO1,GSTT1,MAPT,PRKCE,quinalphos ANGPT2,ASPG,BIRC3,CELSR1,CGAS,CHAC1,CHRNB3,CR1,FASN,GSTM3,HSD3B2,ITGB3,L1CAM,PNLIP,REG1A,SLC5A7,SOD3,SSPOP,SVEP1 19 (11) 8 ACHE RETREG1 other 2 -1.890 9.21E-04 3.10E-03 EIF2AK3,ERN1,RETREG1 BIRC2,BIRC3,CEBPD,DGAT1,FASN,PLIN2,PNLIP 7 (3) 2 Z36 ERN1 CX3CL1 cytokine 2 -0.200 9.26E-04 1.68E-02 Akt,AKT1,CHUK,CX3CL1,CX3CR1,ERK,ERK1/2,Jnk,MAPK1,MAPK14,MAPK3,MAPK8,MAPT,P38 MAPK,SRC,STAT5A ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,ASPG,B4GALT1,BIRC2,CASP2,CD209,CLEC10A,DGAT1,FLNC,HNRNPM,HSD3B2,IFI44,L1CAM,LRP6,MATR3,PGK1,PTPRK,RRM2,SOD3,TNFSF14,TRIM3 25 (16) 15 CDKN2A,IL27,MFN2,NFkB (complex),oleic acid,RETN,TERT,ZFTA-RELA ATF3 AKT1,Ca2+,G protein,HMOX1,IgG,LDL-cholesterol,LGALS3BP,NMDA Receptor CASP3,PDC CASP3 peptidase 0.000 3 0.000 9.37E-04 3.47E-02 ACHE,Akt,APEX1,APP,ATF3,ATM,BIRC2,Calcineurin protein(s),CASP2,CASP3,CASP8,CAT,CDK2,DICER1,E2F3,EIF2AK2,EIF4E,ELAVL1,ESR2,FADD,Hdac,HIPK2,HRAS,hydrogen peroxide,IFNG,IL18,IL1B,MAP3K1,MITF,MYB,MYOD1,NGEF,NR1I2,PPARGC1A,PPP3R1,PRKCD,PRKCG,PRKN,PTEN,SIRT1,SNCA,SOX2,SREBF2,TWIST1 ABCA5,ACAA1,AIMP2,AKNA,ANGPT2,BIRC3,C1QL1,CACHD1,CALCRL,CEBPD,CELSR1,CGAS,CHAC1,CYP39A1,EMILIN2,ETNK1,FASN,FAT4,H2AC21,HCRTR2,L1CAM,Lgals6,LRP4,LRP5,LRP6,MEGF11,NLGN2,PGK1,PIF1,PLG,PRKCSH,RAB11A,REG1A,RRM2,RRP12,SCARF1,SLC5A7,SVEP1,TENM3,THSD4,TNFSF14,TNR,TPPP3,TRAF3IP2,TRIM3,TSG101,TULP4,XPO7 48 (44) 35 1-methyl-4-phenylpyridinium,1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine,2-chloroadenosine,3-methyladenine,5-hydroxydecanoic acid,6-hydroxydopamine,ACHE,acyclic retinoid,adaphostin,ajoene,anandamide,anisomycin,APPL1,Arg-Gly-Asp,arginine,ATF3,ATR,benzo(a)pyrene,BHLHE40,bryostatin 1,Ca2+,caffeic acid phenethyl ester,calcium chloride,CAMP,camptothecin,capivasertib,CAPNS1,carbon tetrachloride,CASR,CCNE1,ceramide,CGP 74514A,chelidonine,chenodeoxycholic acid,ciprofloxacin,clofazimine,cocaine,costunolide,dacinostat,dalfampridine,dATP,daunorubicin,delta-tocopherol,deoxycholate,DIABLO,diquat,doxycycline,etoposide,evodiamine,farnesol,FASLG,fatty acid,gambogic acid,gamma tocopherol,ganglioside,ganglioside GT1,histone deacetylase inhibitor,IL11,indole-3-carbinol,indomethacin,irinotecan,iron,ITPR1,ixabepilone,KT5823,lactacystin,lead,lonafarnib,MAP3K11,MAP3K8,mitomycin C,MK2206,MT-21,N,N-dimethylsphingosine,N1,N11-diethylnorspermine,NCX-4040,NMDA Receptor,NSC 95397,oleic acid,omacetaxine mepesuccinate,paraquat,peptidoglycan,perifosine,peroxynitrite,phytohemagglutinin,piceatannol,plumbagin,prazosin,PRNP,prostaglandin A1,prostaglandin A2,PS-K,S100A9,salinosporamide A,sanguinarine,sorbitol,tanespimycin,tolfenamic acid,tozasertib,trabectedin,TRIB2,tributyltin,TSC22D3,tunicamycin,vatalanib,wogonin,zerumbone,zoledronic acid (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester,4-phenylbutyric acid,8-bromo-cAMP,ACSL1,AKT1,ALDH3A1,aloxistatin,ANGPT1,ARR3,bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate,BMP7,carbon monoxide,CD2AP,CDKN2A,CNTF,cryptotanshinone,CX3CL1,DEFB103A/DEFB103B,deferoxamine,edaravone,eflornithine,EP300,FFAR4,FGF7,FGR,forskolin,fumonisin B1,G6PC3,GAST,GRN,HIPK2,HMOX1,HSH2D,HSPB1,IgG,IL27,KN 93,L-triiodothyronine,Li+,LIF,lycopene,Map3k7,MAP3K7,Mt,nifedipine,NRP2,NTN1,p85 (pik3r),PD 169316,PDGFB,PDGFC,PEA15,phosphatidylinositol 3,4-diphosphate,POU5F1,PPARD,propofol,prostaglandin E2,rhodioloside,roscovitine,RPSA,S-adenosylmethionine,SAA,SCD,SD-282,SFRP1,sildenafil,SLC2A1,SOS2,SPHK1,suramin,tacrolimus,taurocholic acid,telmisartan,TERT,TINCR,TMSB4,tosylphenylalanyl chloromethyl ketone,Trolox C,WNT1,YM-58483,Z-YVAD-FMK,ZEB2 KSR1 Notch group 2 -1.414 9.39E-04 7.90E-03 Akt,AKT1,MAPK14,MAPK8,Notch,NOTCH1,NOTCH3,PI3K (complex) AIMP2,B4GALT1,BIRC2,BIRC3,CLEC10A,DGAT1,FASN,HNRNPM,ITGB3,KRT8,L1CAM,LRP6,MATR3,PGK1,PLG,PTPRK,RRM2,TNFSF14 18 (8) 8 ADAM10,FASLG,Secretase gamma BMS-906024,mir-326 AKT1,CNN1,mir-145,PIK3IP1,POU5F1,TRPC6 LRRK2,NET1,ZEB2 1,2-dioctanoyl-sn-glycerol chemical reagent 3 0.000 9.48E-04 3.08E-02 1,2-dioctanoyl-sn-glycerol,AKT1,ALOX5,Ap1,APP,AR,CDKN1B,CXCL8,EGLN,EIF2AK3,EIF4E,ELAVL1,ESR1,ESR2,ETS2,FOS,GNE,Hdac,HIF1A,HMOX1,HRAS,IGF1,IL2,IRF3,NFATC2,NRAS,PAWR,PDPK1,Pkc(s),PP2A,PRKCE,PRMT1,S100A8,S100A9,SLC18A3,SOX2,SPARC,TGFB1,TNFSF11,TWIST1 ANGPTL3,ANOS1,ATL2,BBX,BCHE,BIRC3,C1QL1,CACHD1,CALM1 (includes others),CALML3,CEBPD,CGAS,CHAC1,CHRNB3,CLPB,CR1,Cyp2d22,FASN,FAT4,FCGBP,FRRS1,HNRNPM,ITGB3,KRT8,LRP4,LRP5,MATR3,MKX,NLGN2,NUBP1,PLG,PNLIP,POU3F3,PTGIR,RAB11A,RRM2,RRP12,SLC16A4,SLC5A7,TENM3,THSD4,TMPRSS6,TNR,TPPP3,TRIM2,TRPM2,TULP4,VPS25 48 (40) 38 R59949 Ca2+ AKT1 NOX3 enzyme 3 -0.980 9.53E-04 4.17E-02 AKT1,Ap1,APP,ATF4,CEBPA,COP1,ESR2,ETS2,FADD,FOS,FOXO1,Gsk3,HIF1A,HMOX1,HRAS,IGF1,IRF3,Jnk,KRT8,LEP,LIPE,MAFB,MDM2,MITF,MLXIPL,MYB,MYC,NOX3,NR1I2,P38 MAPK,PAWR,PGR,PPARA,PPARGC1A,PTEN,RICTOR,RXRA,S100A9,SIRT1,SOX2,SPARC,TNFSF11,TP53 ACAA1,ANGPT2,ANGPTL3,ANK1,ANOS1,ATL2,BCHE,C1QL1,CALCRL,CALM1 (includes others),CASP2,CD209,CELSR1,CHAC1,CLEC10A,CSMD3,CYP39A1,EMILIN2,ETNK1,FRRS1,GSTM3,HCRTR2,HNRNPM,ITGB3,LRP4,MATR3,MKX,MMRN1,NUBP1,PGK1,PIF1,PLIN2,POU3F3,PPP1CA,PTGIR,REG1A,RRP12,RSL24D1,SLC16A4,SLC16A7,SLC5A7,SVEP1,SYT12,TENM3,THSD4,TKFC,TMPRSS6,TPPP3,TRIM2,TULP4,WRN 51 (43) 41 IRS1 AKT1 AKN-028 chemical drug 3 1.134 9.59E-04 2.30E-02 AKN-028,Akt,AKT1,CHEK1,ERK1/2,FLT3,GAB2,GRB2,JAK,Jnk,KIT,MAPK1,MAPK8,MAPT,Mek,MITF,P38 MAPK,PI3K (complex),PTPN11,RAF1,SRC,STAT,STAT1,STAT5A ABCA3,AIMP2,ANGPT2,ANK1,AOC1,ASPG,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,EMX2,FLNC,HNRNPM,HSD3B2,IFI44,ITGB3,KIFC1,L1CAM,MATR3,PGK1,PIF1,PLG,PTPRK,RRM2,SLC16A7,TNFSF14 28 (24) 21 KIT amitriptyline chemical drug 2 -1.414 9.61E-04 7.20E-03 ACHE,amitriptyline,Creb,ERK,ERK1/2,FGFR2,Jnk,P38 MAPK,Pkc(s),SLC6A4 ADGRG6,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,CUBN,DPY19L3,GNAO1,ITGB3,KRT8,PLG,RRM2,SLC5A7,TENM3 18 (10) 9 CYP2B6,NPY,sphingomyelin ACHE,CCND2,ceramide SD-282 chemical drug 2 1.508 9.74E-04 3.20E-03 Ap1,DUSP1,JINK1/2,P38 MAPK,SD-282 ANK1,CALM1 (includes others),CEBPD,CLEC10A,FASN,IFI44,ITGB3,PLG,PLIN2,PTPRK,RRM2 11 (5) 4 JINK1/2 CASP3 PLEKHO2 other 1 -1.414 9.74E-04 1.20E-03 PLEKHO2 BIRC2,BIRC3 2 (1) 1 ZP3 other 3 -0.522 9.78E-04 3.83E-02 Akt,Ca2+,CFTR,cyclic AMP,EGF,ERK,ERK1/2,G protein,G protein alphai,GNA12,GNAS,INSR,Jnk,LIPE,MAPK1,MAPK3,Mmp,NFkB (complex),NFKB1,P38 MAPK,PI3K (complex),PIK3CG,Pkc(s),PLC,PRKCE,PTK2,RELA,ZP3 ACAA1,ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CHRNB3,CLEC10A,CUBN,DGAT1,FCGBP,FLNC,HSD3B2,IFI44,KRT8,L1CAM,LITAF,NCAN,PLG,PLIN2,PPP1CA,PTPRK,RRM2,SNAP25,SOD3,TNFSF14,TSG101 33 (28) 25 Ca2+,G protein beta-cyclodextrin chemical - endogenous non-mammalian 3 1.069 9.81E-04 4.26E-02 26s Proteasome,AKT1,APP,AR,beta-cyclodextrin,CAV1,CDKN1B,CEBPA,CETP,COP1,Creb,CREB1,CTNNB1,EIF4E,ERBB2,ERK,ESR1,ESR2,ETS2,FADD,Fcgr2,FOS,HIF1A,IGF1,IL10,IRF3,IRS1,Jnk,KRT8,MITF,NFATC2,NFkB (complex),NRAS,P38 MAPK,PAWR,PDPK1,PGR,PI3K (complex),PPARA,PPARGC1A,REL,RICTOR,S100A9,SIRT1,SOX2,SPARC,TNF,TNFSF11,TWIST1 ADGRG6,ADRM1,AGA,ALDH7A1,ANK1,ANOS1,ATL2,BBX,BCHE,BIRC3,C1QL1,CD209,CEBPD,CLEC10A,CLPB,CR1,Cyp2d22,DPY19L3,EMILIN2,ETNK1,FASN,FAT4,FRRS1,GSTM3,HCRTR2,HNRNPM,ITGB3,LRP4,LRP6,MATR3,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PIF1,PLG,PLIN2,POU3F3,RAB11A,REG1A,RRP12,RSL24D1,SERINC2,SLC16A4,SLC5A7,SUSD2,SVEP1,SYT12,THSD4,TMPRSS6,TPPP3,TRIM2,TRIM56,TRPM2,VPS25 56 (49) 48 AKT1,IRS1,PRNP CXCL9 cytokine 3 0.289 9.81E-04 3.19E-02 26s Proteasome,ACHE,Akt,CEBPA,COP1,CXCL9,DLX5,ERK,ERK1/2,ESR2,ETS2,HIF1A,HMOX1,HNF4A,HRAS,IGF1,IL10,IRF3,MITF,MYB,NFATC2,NGEF,NR1I3,NRAS,P38 MAPK,PGR,PI3K (complex),PPARA,PPARGC1A,RAC1,RB1,REL,RHOA,RXRA,S100A9,SIRT1,SMAD2,SMAD3,STK11,TCF7L2,TGFB1,TWIST1,VDR ADGRG6,ADRM1,AGA,AIMP2,ANGPT2,ANGPTL3,ANK1,ANOS1,AOC1,ATL2,BBX,BCHE,BIRC2,BIRC3,CALML3,CR1,CUBN,CYP39A1,DGAT1,EMILIN2,FASN,FAT4,FCGBP,FUT6,GSTM3,HCRTR2,KMT5A,L1CAM,MAPK4,MEGF10,MKX,MMRN1,PIF1,PLG,POU3F3,PTPRK,RRM2,RRP12,SCARF1,SLC16A4,SLC5A7,SVEP1,SYT12,TENM3,THSD4,TMPRSS6,TNFSF14,VPS25 48 (43) 39 IL27,NFkB (complex) HMOX1,POU5F1,tacrolimus Ca2+ acyclic retinoid chemical drug 2 1.886 9.84E-04 9.40E-03 acyclic retinoid,Akt,ERK,ERK1/2,KDR,RB1,RXRA ADGRG6,AIMP2,ANGPT2,ANGPTL3,AOC1,BIRC2,BIRC3,CALCRL,CEBPD,CELSR1,FASN,H2BC21,ITGB3,L1CAM,MAPK4,PLG,RRM2,TNFSF14 18 (7) 6 CASP3 PDGFRA,RXRA MSTN growth factor 3 -1.511 9.88E-04 3.50E-02 ACHE,Akt,AMPK,APP,AR,ATF2,CEBPA,COP1,CREB1,DLX5,EIF2AK3,EIF4E,ELAVL1,ERK1/2,ESR2,ETS2,FADD,FOS,HRAS,IGF1,IL10,Jnk,MDM2,MITF,MLXIPL,MSTN,MYB,MYC,Nfat (family),NFATC2,NGEF,NPAT,NR1I3,P38 MAPK,PAK2,PDPK1,PPARA,RAF1,RICTOR,RXRA,S100A9,SIRT1,SMAD2,SMAD3,TGFB1,TNF,TP53,VDR AIMP2,ANGPT2,ANGPTL3,ANK1,AOC1,ATL2,B4GALT1,BBX,BCHE,BIRC3,CACHD1,CALML3,CD209,CEBPD,CLEC10A,CR1,CSMD3,CUBN,Cyp2d22,CYP39A1,DGAT1,ETNK1,H2BC21,HCRTR2,ITGB3,L1CAM,MGAT4C,MKX,MMRN1,NLGN2,NUBP1,PIF1,PNLIP,POU3F3,PTPRK,RAB11A,RRM2,RRP12,RSL24D1,SCARF1,SERINC2,SLC16A7,SLC5A7,SYT12,TENM3,THSD4,TKFC,TNFSF14,TNR,TPPP3,TRIM56,TULP4,WRN 53 (48) 44 AKT1,NFkB (complex),SENP2 suramin ATF2,SLC2A1 BMP7,CAV3,IBSP SLC3A2 transporter 2 -1.291 9.90E-04 5.80E-03 Akt,AKT1,ITGB1,PI3K (complex),SLC3A2,SRC AIMP2,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,ITGB3,L1CAM,LRP6,MATR3,PGK1,PLG,RRM2,TNFSF14,TNXB 15 (6) 5 eflornithine,GDF2,lactacystin,SYVN1 TAS1R3 Integrin alpha 3 beta 1 L-methionine chemical - endogenous mammalian 3 -0.617 9.91E-04 2.97E-02 26s Proteasome,ACHE,Akt,APP,CDKN1B,CDKN2A,CEBPA,DLX5,EIF2AK3,EIF2AK4,EIF4E,ELAVL1,ERK1/2,ESR2,ETS2,FADD,FMR1,IFNAR1,IGF1R,IRS1,IRS2,Jnk,KAT2A,KRT8,L-methionine,MITF,NGEF,NR1I3,NRAS,p70 S6k,PI3K (complex),PI3K (family),PIK3R1,PPARGC1A,PRKCD,REL,RPS6KB1,SREBF2,TNF ADRM1,AGA,AIMP2,ANGPT2,AOC1,CACHD1,CD209,CEBPD,CGAS,CHAC1,CLEC10A,CLPB,CYP39A1,EMILIN2,ETNK1,FAM111A,FASN,HSD3B2,ITGB3,L1CAM,MEGF10,MKX,MMRN1,NLGN2,PIF1,PNLIP,POU3F3,PTPRK,REG1A,RRM2,RRP12,SCARF1,SLC5A7,SVEP1,SYCE2,THSD4,TNFSF14,TNR,TPPP3,TRIM56,TULP4,VPS25 42 (39) 34 IRS1,RPS6KB1,S-adenosylmethionine LPIN1 phosphatase 3 -0.577 9.99E-04 2.66E-02 CDKN1B,CEBPA,CLOCK,EGFR,ERK1/2,ESR2,ETS2,FADD,GNE,Hdac,HIF1A,IGF1,IL10,IL2,IRF3,ITGB1,Jnk,JUN,KRT8,LPIN1,MITF,MYB,NFATC4,NR5A2,NRAS,P38 MAPK,PDPK1,Pkc(s),PPARG,PPARGC1A,PRKCA,PRKCE,progesterone,PSEN1,RICTOR,SREBF1,STAT5B,STK11,TGFB1,TNF,TWIST1 ACAA1,ANGPT2,ANK1,ANOS1,AOC1,ATL2,BIRC3,CALML3,CD209,CEBPD,CGAS,CHAC1,CHRNB3,CLEC10A,CLPB,CR1,DGAT1,DPY19L3,EMILIN2,ETNK1,FAM111A,FASN,FAT4,GLB1,ITGB3,KRT8,LRP4,MEGF10,MKX,MMRN1,PIF1,PLG,PLIN2,PNLIP,POLI,PTGIR,RAB11A,REG1A,RRP12,RSL24D1,SLC16A4,SVEP1,TMPRSS6,TNR,TNXB,TRIM56,TULP4,VPS25 48 (41) 39 4beta-hydroxycholesterol,CREB3L3,GW3965,NF-Y,NPY,tolylfluanid Ca2+,miR-217-5p (and other miRNAs w/seed ACUGCAU),oleic acid,tunicamycin PPARA RETN hemicholinium 3 chemical reagent 2 0.258 1.00E-03 6.10E-03 Ap1,hemicholinium 3,Jnk,MAPK1,MAPK3,P38 MAPK,Pkc(s) ANK1,B4GALT1,BIRC3,CALM1 (includes others),CD209,CEBPD,CLEC10A,FLNC,IFI44,ITGB3,KRT8,PLG,PTPRK,RRM2,SLC5A7 15 (7) 7 CCN5 growth factor 2 -0.728 1.02E-03 9.20E-03 CCN5,CTNNB1,Jnk,MAPK1 ACAA1,BIRC3,CD209,CLEC10A,EMX2,FASN,FLNC,IFI44,ITGB3,KIFC1,KRT8,L1CAM,PGK1,PLG,PLIN2,PTPRK,SUSD2 17 (4) 4 EPAS1,PGR,SEMA7A,tributyltin,WNT1,WNT3A miR-34a-5p (and other miRNAs w/seed GGCAGUG),S100A9,SALL4 KRT18,LRP6,SDC4 PROCR CCND2 other 2 -1.000 1.02E-03 6.60E-03 26s Proteasome,CCND2,CDK2,GATA4,MAPK14,RB1,RBL2 ADRM1,ANGPT2,BIRC2,BIRC3,CALCRL,CEBPD,CELSR1,EMX2,FASN,H2BC21,HSD3B2,KIFC1,LRP6,MAPK4,RRM2,SNAP25 16 (7) 6 8-bromo-cAMP,AKT1,Ca2+,CAPNS1,caspase,CASR,forskolin,HIPK2,Hsp90,IL27,iron,lactacystin,NFkB (complex),PD 169316,PHIP,phytohemagglutinin,PIK3CD,PPP3R1,SALL4,TFF2,VAV1,WNT3A AHNAK,amitriptyline,CDKN2A,CDX1,deferoxamine,FOXO4,IgG,infliximab,INHA,KIT,PCGF2,PD173074,phorbol 12,13-dibutyrate,piceatannol,PPARD CCNE1 (1S,2R)-NCL-1 chemical reagent 2 -1.890 1.04E-03 3.90E-03 (1S,2R)-NCL-1,EIF2AK3,ERN1 BIRC2,BIRC3,CEBPD,DGAT1,FASN,PLIN2,PNLIP 7 (3) 2 ATF3,ERN1,PPP1R15A TNFRSF11A NCD-38 chemical reagent 2 -1.890 1.04E-03 3.90E-03 EIF2AK3,ERN1,NCD-38 BIRC2,BIRC3,CEBPD,DGAT1,FASN,PLIN2,PNLIP 7 (3) 2 ATF3,ERN1,PPP1R15A TNFRSF11A PPP1R9A other 3 -0.730 1.05E-03 3.23E-02 Akt,BCL2,Creb,ERK1/2,Jnk,MAP2K1,MAPK1,MAPK3,NFKBIA,NR1I2,P38 MAPK,PP1 protein complex group,Ppp1cc,PPP1R9A,RB1,SLC6A4,TAFAZZIN,YBX1 ADRM1,AIMP2,ANGPT2,AOC1,B4GALT1,CALCRL,CD209,CEBPD,CELSR1,CLEC10A,CYP39A1,DPY19L3,FLNC,GNAO1,GSTM3,H2BC21,HSD3B2,IFI44,ITGB3,KRT8,L1CAM,LITAF,MAPK4,NCAN,PLG,PTPRK,RRM2,SNAP25,SOD3,TNFSF14 30 (18) 15 Ppp1cc Pdi group 3 0.853 1.06E-03 1.78E-02 Akt,CXCL8,F10,F2,F2R,F3,F5,Focal adhesion kinase,HGF,MAPK1,MAPK14,MAPK3,MAPK8,nitric oxide,Pdi,PDIA2 AIMP2,B4GALT1,CALCRL,CALM1 (includes others),CASP2,CEBPD,CELSR1,CR1,DGAT1,FASN,FLNC,IFI44,KRT8,L1CAM,LGMN,LRP6,MMRN1,PLG,PTPRK,RRM2,SLC16A4,TNFSF14 22 (16) 12 F10 equol chemical - endogenous non-mammalian 2 1.000 1.06E-03 7.80E-03 Akt,equol,ERK,ERK1/2,FOS,NOS3 ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,HSD3B2,KRT8,L1CAM,NUBP1,PLG,RRM2,SOD3,TNFSF14 16 (6) 5 ESR2 MLN7243 chemical drug 2 -1.633 1.08E-03 3.60E-03 ERN1,MLN7243,UBA1 BIRC2,BIRC3,CEBPD,DGAT1,FASN,PLIN2 6 (3) 2 ERN1 UBA1 pralidoxime chemical drug 3 1.732 1.08E-03 3.07E-02 ACHE,Akt,AKT1,CHRM1,CHRM2,CHRM3,CNR1,EGFR,ERK,ERK1/2,LEF1,MAPK1,MAPK14,MAPK8,MAPK9,MAPT,Nfat (family),Pkc(s),pralidoxime,PRKCE,RGS4 ADGRG6,AIMP2,ANGPT2,AOC1,ASPG,BIRC2,CHRNB3,DGAT1,FLNC,GNAO1,HNRNPM,IFI44,ITGB3,KRT8,LRP4,LRP6,MATR3,MEGF6,PLG,PLIN2,PTPRK,RRM2,SLC5A7,SOD3,SSPOP,TNFSF14,TNXB 27 (21) 17 ACHE CHRM1,CHRM2 Dynamin group 3 -0.555 1.09E-03 3.91E-02 26s Proteasome,Akt,AKT1,ATF4,CASP1,CDKN1B,CEBPA,Creb,CYP19A1,DLX5,Dynamin,EIF4E,ERK,ERK1/2,ETS2,FOS,GLI1,HNF4A,IL1,IL1B,IRF3,Mapk,MAPK7,MAPT,MITF,MYB,NFATC2,NFKB2,NFKBIA,NGEF,NR1I3,NRAS,PGR,PI3K (complex),PPARA,PPP3R1,PRKCI,REL,SMAD2,SMAD3,SOX2,SPARC,TGFB1,TNFSF11,TWIST1,VDR ABCA5,ADGRG6,ADRM1,AGA,AIMP2,ANGPT2,ANOS1,AOC1,ASPG,BBX,C1QL1,C1QTNF3,CALML3,CEBPD,CHAC1,CLPB,CUBN,CYP39A1,DGAT1,DPY19L3,FASN,FAT4,FCGBP,FRRS1,FUT6,GSTM3,HNRNPM,IFI44,ITGB3,KRT8,L1CAM,LITAF,LRP4,MATR3,MKX,MMRN1,NCAN,NLGN2,NUBP1,PIF1,PLG,POU3F3,PTPRK,RRM2,SCARF1,SOD3,TNFSF14,TNR,TRAF3IP2,TRIM2,TULP4,VPS25 52 (46) 42 phosphatidylinositol BCAR1,CNTF AKT1,MAPK7 zoledronic acid chemical drug 2 Activated 2.058 1.09E-03 4.49E-02 Akt,AKT1,BCL2,CYP19A1,ERK,ERK1/2,Focal adhesion kinase,GSK3B,MMP9,paclitaxel,RAF1,RAS,RELA,SMAD3,STAT3,TP53,zoledronic acid ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,ASPG,B4GALT1,BIRC2,BIRC3,CALCRL,CASP2,CD209,CEBPD,CELSR1,CSMD3,DGAT1,DUT,GLB1,HNRNPM,ITGB3,KIFC1,KRT8,L1CAM,MATR3,PGK1,PLG,PLIN2,PPP1CA,PTPRK,RRM2,SLC16A7,SNAP25,TNFSF14,TSG101 34 (17) 16 CASP3,IgG AKT1,ceramide,Focal adhesion kinase,GGPS1,IRAK3,LPAR1,NOX4,TNFRSF11A RAC2 enzyme -0.000 2 -0.894 1.11E-03 9.60E-03 Akt,ELAVL1,ERK1/2,Jnk,MAPK1,MAPK14,P38 MAPK,RAC2 AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CACHD1,CASP2,CD209,CEBPD,CLEC10A,FASN,FLNC,ITGB3,L1CAM,LRP6,PLG,PTPRK,RRM2,TNFSF14 20 (8) 7 8-bromo-cAMP,ENG,HIPK2,ITGA4,VAV1,WNT5A AKT1,cyclophosphamide CDH5,PLD1 CLEC7A transmembrane receptor 2 -0.853 1.12E-03 1.34E-02 Ap1,CLEC7A,ERK,IRF1,Jnk,Nfat (family),NFATC2,NFkB (complex),P38 MAPK,PTPN11,REL,RELA ABCA3,ADGRG6,AGA,ALDH7A1,ANK1,B4GALT1,BBX,BIRC2,CALM1 (includes others),CASP2,CD209,CEBPD,CLEC10A,DUT,FASN,IFI44,ITGB3,PLG,PTPRK,RRM2,SOD3,TNFSF14 22 (12) 11 CNTF,mir-182 PPARD caspase,CCL3L3,CCR7,NFkB (complex) Dynamin group 2 -1.279 1.13E-03 1.70E-02 Akt,AKT1,CASP1,Creb,Dynamin,ERK,ERK1/2,IRF3,MAPK7,NFKBIA,PRKCI,SMAD3 ADGRG6,AIMP2,ANGPT2,ANOS1,AOC1,CEBPD,DGAT1,DPY19L3,FASN,HNRNPM,IFI44,ITGB3,KRT8,L1CAM,LITAF,MATR3,NCAN,PLG,PTPRK,RRM2,SOD3,TNFSF14 22 (12) 11 phosphatidylinositol BCAR1,CNTF AKT1,MAPK7 RPL22 translation regulator 2 1.890 1.14E-03 3.40E-03 EIF2AK3,ERN1,RPL22 BIRC2,BIRC3,CEBPD,DGAT1,FASN,PLIN2,PNLIP 7 (3) 2 ATP2B2 ATF3,ERN1,miR-34a-5p (and other miRNAs w/seed GGCAGUG) MAPK8IP3 other -0.000 2 -0.577 1.14E-03 3.70E-03 ERK,Focal adhesion kinase,Jnk,MAPK8,MAPK8IP3,MAPK9 ADGRG6,B4GALT1,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FASN,KRT8,PLG,PLIN2,SOD3 12 (6) 5 Sapk Pdpk group 2 Inhibited -2.309 1.14E-03 3.60E-03 Akt,AKT1,Pdpk,PDPK1 AIMP2,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,L1CAM,MATR3,PLG,RAB11A,RRM2,TNFSF14 12 (4) 3 delta-tocotrienol AKT1 cinaciguat chemical drug 3 -1.886 1.16E-03 9.60E-03 Akt,ATF6,cinaciguat,Creb,ERK1/2,NOS3,RB1,RYR2,sGC AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CALCRL,CELSR1,DPY19L3,H2BC21,ITGB3,KRT8,L1CAM,MAPK4,PLG,PLIN2,RRM2,SOD3,TNFSF14 18 (9) 7 sGC aldehyde chemical - endogenous mammalian 3 -0.174 1.16E-03 3.65E-02 ACE,AGT,aldehyde,CREB1,CTNNB1,EGFR,ERK1/2,INSR,Jnk,MAPK1,MAPK3,mitomycin C,NFkB (complex),Pkc(s),XDH ACAA1,ALDH7A1,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CLEC10A,CR1,DGAT1,EMX2,FCGBP,FLNC,IFI44,ITGB3,KIFC1,KRT8,L1CAM,LITAF,MGAT4C,PLG,PLIN2,PNLIP,PTPRK,REG1A,SERINC2,SOD3,SSPOP,SUSD2,SVEP1,TNXB,TULP4 33 (15) 12 sodium azide XDH fatty acid chemical - endogenous mammalian 2 0.000 1.17E-03 4.08E-02 Akt,AKT1,EIF2AK3,fatty acid,INSR,Jnk,JUN,MAPK1,MAPK3,MAPK8,NFkB (complex),NR1H3,P38 MAPK,PAK2,Pkc(s),PPARA,PPARD,PPARG,PRKCZ,PTGS2,SERPINE1 ACAA1,AIMP2,ALDH7A1,ANGPT2,ANGPTL3,ANK1,AOC1,B4GALT1,CASP2,CD209,CLEC10A,CYP39A1,DGAT1,FASN,FCGBP,FLNC,GSTM3,HNRNPM,HSD3B2,IFI44,ITGB3,KRT8,L1CAM,MATR3,PLIN2,PNLIP,POLI,PTPRK,RRM2,SERINC2,TNFSF14,WRN 32 (21) 21 ACSL1,CIDEB,CIDEC,CRBN,D-fructose,EHHADH,ellagic acid,FGF7,L-triiodothyronine,oleic acid,RETN,SOST CAV3,INS,KDM3A,quercetin,RGS4,SCP2,sildenafil,SLC30A7 CASP3,ceramide,FFAR1,FFAR4,GPAM,HMOX1,HSPB1,JINK1/2,LHB,NFkB (complex),PAK2,SLC2A1,SOCS3 AKT1 MAP3K6 kinase 2 -1.155 1.18E-03 3.30E-03 Jnk,MAP3K6,MAPK8,MAPK9,P38 MAPK ANK1,B4GALT1,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FASN,ITGB3,PLG,PLIN2,SOD3 12 (5) 4 POR fluvoxamine chemical drug 2 -0.577 1.18E-03 3.00E-03 AKT1,CYP1A1,CYP1A2,ERK,fluvoxamine,NOS3,SLC6A4 ADGRG6,BIRC3,CACHD1,CEBPD,FASN,GNAO1,GSTM3,HNRNPM,ITGB3,MATR3,PLG,SOD3 12 (7) 6 AKT1 CNTF cytokine 2 -0.539 1.19E-03 3.66E-02 Akt,CEACAM1,CNTF,ERK1/2,GRB2,IL6ST,JAK,Jnk,MAPK1,N-cor,NFkB (complex),NFKBIA,P38 MAPK,PRKAA1,PRKAA2,PTPN11,RAF1,STAT1,STAT3 ABCA3,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,BCHE,CD209,CEBPD,CGAS,CLEC10A,EMX2,FASN,FLNC,H2BC21,IFI44,ITGB3,KRT8,L1CAM,LITAF,MFSD1,NCAN,PGK1,PLG,PLIN2,PTPRK,RRM2,SLC16A7,SLC5A7,SOD3,TNFSF14 31 (19) 19 GDF2,PTN KT5823 ATF3,CISH,CLEC7A,GABARAP,GRN,HMOX1,IRS1,LIF,N-cor,NTRK1,OSMR,PLC gamma,PRKAA1,SAA1,SATB2,SOCS3,TAP1,VAV1,WNT5A,XDH ACHE,ANGPT1,CASP3,Dynamin,FGF9,NPY,PENK,prostaglandin E2,SCD 1-methyl-4-phenylpyridinium chemical toxicant 2 -1.877 1.20E-03 1.92E-02 1-methyl-4-phenylpyridinium,26s Proteasome,Akt,CDK5,EIF2AK3,ERN1,Jnk,JUN,MAPK1,MAPK8,MAPT,RB1 ADRM1,AIMP2,ANGPT2,ASPG,CALCRL,CD209,CEBPD,CELSR1,CLEC10A,DGAT1,FASN,FLNC,GLB1,H2BC21,IFI44,ITGB3,L1CAM,MAPK4,PLIN2,PNLIP,POLI,PTPRK,TNFSF14 23 (12) 11 Ca2+,CASP3,caspase,ERN1,iron,NFkB (complex),radical MFN2,SOD1 Cofilin group 3 -1.400 1.20E-03 2.61E-02 Akt,AKT1,ANXA1,CFL1,Cofilin,ERK,ERK1/2,IGF1,Jnk,LIMK1,MAPK14,MAPK8,Na+,K+ -ATPase,NFkB (complex),PDPK1,PLD1,SPHK1,SRC,SRC (family) ADGRG6,AIMP2,ALDH7A1,ANGPT2,AOC1,ATL2,B4GALT1,BIRC2,BIRC3,CD209,CLEC10A,DGAT1,HNRNPM,ITGB3,L1CAM,LRP6,MATR3,PGK1,PLG,PLIN2,RAB11A,RRM2,SOD3,THSD4,TNFSF14 25 (19) 14 allyl isothiocyanate,Beta Arrestin,KN 93,lith-O-Asp,MK2206,NMDA Receptor,NOX1,NPHS1,NRG (family),PF-3758309,prostaglandin E2,SDCBP,STO-609 CCR7,Pak,PAK2,PRKD2 Na+,K+ -ATPase,PLD1 XDH enzyme -0.000 2 -0.186 1.25E-03 3.04E-02 CREB1,CTNNB1,EGFR,ERK1/2,INSR,Jnk,MAPK1,MAPK3,mitomycin C,NFkB (complex),Pkc(s),XDH ACAA1,ALDH7A1,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CLEC10A,DGAT1,EMX2,FCGBP,FLNC,HSD3B2,IFI44,ITGB3,KIFC1,KRT8,L1CAM,LITAF,MGAT4C,PLG,PLIN2,PTPRK,SERINC2,SOD3,SUSD2,TNXB,TULP4 29 (12) 11 CNTF,doxycycline,NCOA3 acetylcholine,aldehyde,HOXA10,NADH,quercetin mitomycin C,NFkB (complex),SLC2A1,TJP1 PPARA glycopyrrolate chemical drug 3 1.347 1.26E-03 3.38E-02 ACHE,Akt,AKT1,CHRM1,CHRM2,CHRM3,CHRM5,CNR1,EGFR,ERK,ERK1/2,glycopyrrolate,LEF1,MAPK1,MAPK14,MAPK8,MAPK9,MAPT,Nfat (family),Pkc(s),PRKCE,RGS4 ADGRG6,AIMP2,ANGPT2,AOC1,ASPG,BIRC2,CHRNB3,DGAT1,FLNC,GNAO1,HNRNPM,IFI44,ITGB3,KRT8,LRP4,LRP6,MATR3,MEGF6,PLG,PLIN2,PTPRK,RRM2,SLC5A7,SOD3,SSPOP,TNFSF14,TNXB 27 (22) 17 ACHE,CHRM1,CHRM2 PTN growth factor 1 0.000 1.30E-03 1.90E-03 PTN DGAT1,FASN,ITGB3,PLIN2 4 (1) 1 MEN1 CNTF,Collagen type II,Focal adhesion kinase,GPAM,IRS1,PC,phospholipid,PLC gamma,PPARA,RXRA,SCD DEFB103A/DEFB103B other 3 -1.234 1.30E-03 3.91E-02 AKT1,APP,CASP3,CDKN1B,COP1,DEFB103A/DEFB103B,DICER1,EIF4E,ERK,ERK1/2,ETS2,FADD,HIF1A,IGF1,IL10,IRF3,Jnk,KRT8,MYB,NFATC2,NR1I3,P38 MAPK,PPARGC1A,PRKAA1,RB1,RICTOR,RXRA,S100A9,SIRT1,STAT1,STK11,TNF,TWIST1 ADGRG6,ANGPTL3,ANK1,ANOS1,AOC1,ATL2,BBX,BCHE,BIRC2,CASP2,CD209,CEBPD,CLEC10A,CLPB,CR1,CYP39A1,EMILIN2,ETNK1,FAT4,FCGBP,H2BC21,HCRTR2,HNRNPM,LRP5,MAPK4,MATR3,MEGF10,MKX,NLGN2,PLG,POU3F3,REG1A,RSL24D1,SLC16A4,SVEP1,SYT12,THSD4,TMPRSS6,TNR,TPPP3,TRIM56,TULP4 42 (33) 31 NFkB (complex) IL31 CASP3 CDC34 enzyme 2 0.500 1.31E-03 8.60E-03 CDC34,CDKN1B,CTNNB1,NFKBIA ACAA1,BIRC2,BIRC3,CEBPD,CLPB,EMX2,FASN,KIFC1,KRT8,L1CAM,LITAF,NCAN,PGK1,PLIN2,SOD3,SUSD2 16 (4) 3 CHRM1 G-protein coupled receptor 2 -1.225 1.33E-03 2.54E-02 Akt,AKT1,CHRM1,CNR1,EGFR,ERK1/2,MAPK1,MAPK14,MAPK3,MAPK8,MAPK9,Nfat (family),Pkc(s),RGS4 AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,DGAT1,FLNC,HNRNPM,IFI44,ITGB3,KRT8,L1CAM,LRP4,LRP6,MATR3,MEGF6,PLG,PLIN2,PTPRK,RRM2,SOD3,SSPOP,TNFSF14,TNXB 24 (14) 13 acetylcholine,arecoline glycopyrrolate,GRK2,ketotifen,physostigmine,pralidoxime,quinidine,scopolamine AKT1,RGS4 NTSR2 G-protein coupled receptor 2 -1.291 1.33E-03 6.80E-03 Akt,ERK1/2,Jnk,NTSR2,P38 MAPK,SRC AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,L1CAM,PGK1,PLG,RRM2,TNFSF14 15 (6) 5 TINCR other 2 Activated 2.000 1.33E-03 7.20E-03 CTNNB1,ERK1/2,P38 MAPK,TINCR ACAA1,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CEBPD,CHAC1,EMX2,FASN,ITGB3,KIFC1,L1CAM,PGK1,PLIN2,SUSD2 16 (4) 4 miR-133a-3p (and other miRNAs w/seed UUGGUCC) KRT10,PDK1 CASP3,EPAS1,PDGFB Fc gamma receptor group 2 -1.177 1.34E-03 3.03E-02 Akt,AKT1,CD36,ERK,Fc gamma receptor,GAB2,Jnk,MAPK1,MAPK3,NFkB (complex),NOS3,P38 MAPK,RB1 ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,B4GALT1,CALCRL,CD209,CEBPD,CELSR1,CLEC10A,DGAT1,FASN,FLNC,H2BC21,HNRNPM,IFI44,ITGB3,L1CAM,MAPK4,MATR3,PLG,PTPRK,RRM2,SOD3,TNFSF14 26 (13) 12 IgG AKT1,CCNE1,LCP2,NFkB (complex),SOCS3 Cebp complex 3 -1.521 1.34E-03 4.86E-02 Akt,Cebp,CEBPA,CEBPB,CEBPD,CYP19A1,HIF1A,IL6ST,INSR,NFkB (complex),PI3K (complex),PPARG,PRKCE,SREBF1,STAT3,TFAP2A,VitaminD3-VDR-RXR ABCA3,ACAA1,AIMP2,ALDH7A1,ANGPT2,AOC1,ASPG,B4GALT1,BIRC3,CD209,CEBPD,CGAS,CHRNB3,DPY19L3,DUT,EMX2,FASN,FCGBP,GLB1,HSD3B2,ITGB3,L1CAM,LGMN,LITAF,LRP5,MMRN1,PGK1,PLG,PLIN2,RRM2,SLC16A4,SLC5A7,SOD3,TMPRSS6,TNFSF14 35 (17) 15 SAA bile acid chemical - endogenous mammalian 2 -1.800 1.34E-03 2.51E-02 Akt,Ap1,bile acid,ERK1/2,JINK1/2,Jnk,JUN,Mmp,NFKB1,NR1H4,NR1I2,NR5A2,P38 MAPK,Pkc(s),STAT3,VDR AIMP2,ANGPT2,ANK1,AOC1,BIRC3,CALM1 (includes others),CD209,CEBPD,CLEC10A,CUBN,CYP39A1,GNAO1,GSTM3,ITGB3,KRT8,L1CAM,PGK1,PLG,PLIN2,PNLIP,POLI,PPP1CA,RRM2,SOD3,TNFSF14 25 (16) 15 ATF3,Ca2+,CREB3L3,POR,taurocholic acid FGFR4,PPARA,S-adenosylmethionine,SCD,SCP2 caspase,DIO2,JINK1/2,NR5A2,tauroursodeoxycholic acid N-acetyl-L-aspartic acid chemical - endogenous mammalian 1 0.000 1.36E-03 3.80E-03 N-acetyl-L-aspartic acid DGAT1,FASN 2 (1) 1 pilocarpine,TFAM ST13 other 0.000 1 0.000 1.36E-03 9.00E-04 ST13 CEBPD,DGAT1 2 (1) 1 ammonium,caffeic acid phenethyl ester MAP4K3 kinase 0.000 2 -0.632 1.36E-03 2.50E-03 Jnk,MAP3K1,MAP4K3,MAPK8,MAPK9 B4GALT1,BIRC2,BIRC3,CD209,CLEC10A,DGAT1,FASN,PLG,PLIN2,SOD3 10 (5) 4 Sapk SCP2 transporter -0.000 2 -1.732 1.36E-03 3.70E-03 SCP2,SOAT1 ACAA1,FASN,PLIN2 3 (2) 2 HNF4A,PPARA EHHADH,HSD17B4,MAP4K4 bile acid,fatty acid,LDL-cholesterol,phospholipid,sphingomyelin miR-133a-3p (and other miRNAs w/seed UUGGUCC) mature microRNA 2 -1.508 1.37E-03 3.00E-03 AKT1,ERK1/2,miR-133a-3p (and other miRNAs w/seed UUGGUCC) ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,ITGB3,MATR3,PLG,PTPRK 11 (3) 3 INS,L-triiodothyronine AKT1 TINCR FFAR1 G-protein coupled receptor 2 -0.471 1.37E-03 1.17E-02 Akt,CaMKII,Creb,ERK1/2,FFAR1,PPARGC1A AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,DGAT1,DPY19L3,EMILIN2,FASN,HSD3B2,ITGB3,L1CAM,PLG,PLIN2,RRM2,SVEP1,TNFSF14 18 (6) 5 fatty acid,oleic acid Ca2+ SLC2A1 DUSP3 phosphatase -0.000 2 -0.426 1.37E-03 1.84E-02 Akt,DUSP3,EGFR,ERK,FGFR2,INSR,MAPK1,MAPK3,MAPK8,MAPK9 ADGRG6,AIMP2,B4GALT1,BIRC2,BIRC3,CEBPD,CUBN,FASN,FCGBP,FLNC,HSD3B2,IFI44,ITGB3,L1CAM,PLG,PLIN2,PTPRK,RRM2,SOD3,TENM3,TNFSF14,TNXB 22 (10) 9 Pam3-Cys chemical toxicant 2 -1.460 1.37E-03 1.91E-02 Akt,ERK,ERK1/2,Jnk,MAPK14,MAPK8,MKNK1,NFkB (complex),P38 MAPK,Pam3-Cys,RELA,TLR2 ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FASN,GNAO1,ITGB3,L1CAM,LRP6,PLG,RRM2,SNAP25,SOD3,TNFSF14 23 (12) 11 CXCL10,FPR1,IFNB1,NFkB (complex),POU2AF1 TIRAP PLCB3 enzyme 0.000 2 -1.342 1.38E-03 1.36E-02 ERK,KRAS,MAPK1,MAPK3,MAPK8,MAPK9,NRAS,P38 MAPK,PLCB3,PRKCD,PRKCE ADGRG6,AIMP2,ANK1,B4GALT1,BIRC2,BIRC3,CALCRL,CEBPD,CHRNB3,DGAT1,FASN,FLNC,IFI44,ITGB3,PLIN2,PPP1CA,PTPRK,SOD3,TULP4,VPS25 20 (11) 10 G protein,G protein beta gamma L-cysteine,SCH79797 Ca2+ BCAR1 enzyme 2 -0.655 1.40E-03 1.79E-02 Akt,BCAR1,EGFR,ERK1/2,Focal adhesion kinase,Jnk,MAPK8,MMP2,PTK2,SMAD3,SRC (family),STAT5B AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CASP2,CD209,CLEC10A,CYP39A1,DGAT1,HSD3B2,ITGB3,KRT8,L1CAM,MMRN1,PLG,PTPRK,RRM2,TNFSF14,TNXB 21 (12) 11 anandamide,Ca2+,Ecm,Fc receptor,thyroid hormone 8-bromo-cAMP,ENG,lactacystin MMP7 Dynamin Ppp1cc phosphatase 2 0.943 1.42E-03 1.11E-02 ERK1/2,Jnk,Map3k7,NFKBIA,P38 MAPK,Ppp1cc,RB1 ANGPT2,ANK1,AOC1,CALCRL,CD209,CEBPD,CELSR1,CLEC10A,FASN,H2BC21,ITGB3,KRT8,LITAF,MAPK4,NCAN,PLG,RRM2,SOD3 18 (7) 6 PPP1R9A,PPP1R9B Map3k7 Scf Trcp beta complex 2 0.258 1.42E-03 9.60E-03 CTNNB1,NFKBIA,Scf Trcp beta ACAA1,BIRC2,BIRC3,CEBPD,EMX2,FASN,KIFC1,KRT8,L1CAM,LITAF,NCAN,PGK1,PLIN2,SOD3,SUSD2 15 (3) 2 PIK3CG kinase 2 -1.134 1.43E-03 3.49E-02 Akt,AKT1,CEBPB,ERK,ERK1/2,MAPK1,MAPK3,MAPK8,NFkB (complex),NOS3,P38 MAPK,PAK2,PDPK1,PIK3CG,PRKCZ,SRC ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,CASP2,CEBPD,DGAT1,DUT,FASN,FLNC,HNRNPM,IFI44,ITGB3,KRT8,L1CAM,LGMN,MATR3,PGK1,PLG,PTPRK,RAB11A,RRM2,SOD3,TNFSF14,WRN 28 (16) 16 14,15-epoxyeicosatrienoic acid,G protein,G protein beta gamma,G Protein I,GRK2,leukotriene B4 as-604850,IC87114,IRS1,PIK3CA,prednisolone,prostaglandin E2,RAPGEF3 AKT1,HMOX1,NFkB (complex),PAK2,PLC gamma CXCL10,PIK3CD,TAP1 12(S)-hydroxyeicosatetraenoic acid chemical - endogenous non-mammalian 2 -1.043 1.43E-03 1.69E-02 12(S)-hydroxyeicosatetraenoic acid,ABCG1,Creb,ERK1/2,Focal adhesion kinase,Jnk,Mek,NFkB (complex),P38 MAPK,PPARD,PPARG ACAA1,ALDH7A1,ANGPT2,ANGPTL3,ANK1,AOC1,BIRC2,BIRC3,CASP2,CD209,CEBPD,CLEC10A,CYP39A1,DGAT1,DPY19L3,FASN,FCGBP,KRT8,PLG,PLIN2,RRM2,SERINC2,SOD3 23 (11) 10 Ca2+,Focal adhesion kinase,NFkB (complex),PPARD GRN growth factor 0.000 2 Inhibited -2.065 1.44E-03 1.35E-02 Akt,AKT1,EIF2AK3,ERK1/2,GRN,SIRT1 AIMP2,ANGPT2,AOC1,BIRC2,CEBPD,CLEC10A,HCRTR2,HNRNPM,IFI44,ITGB3,L1CAM,MATR3,PLG,PNLIP,PTPRG,RRM2,SOD3,TNFSF14,TSG101 19 (6) 6 apicularen A,ciprofloxacin,CNTF,forskolin,tunicamycin lithocholic acid AKT1,ANGPT1,RPS6KB1 CASP3,MERTK,PROS1,TREM2 CHRM2 G-protein coupled receptor 2 Inhibited -2.132 1.44E-03 1.67E-02 Akt,AKT1,CHRM2,EGFR,ERK,ERK1/2,MAPK1,MAPK14,RAS,RGS4 ADGRG6,AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,FLNC,HNRNPM,IFI44,ITGB3,L1CAM,LRP6,MATR3,MEGF6,PLG,PTPRK,RRM2,SSPOP,TNFSF14,TNXB 22 (10) 9 8-bromo-cAMP,acetylcholine,ACHE,arecoline,GRK2 glycopyrrolate,pralidoxime,quinidine,scopolamine AKT1,RGS4 DUSP2 phosphatase 2 -1.291 1.46E-03 1.39E-02 Ap1,DUSP2,ERK1/2,Jnk,MAPK1,Nfat (family),P38 MAPK ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CALM1 (includes others),CD209,CEBPD,CLEC10A,FLNC,IFI44,PLG,PTPRK,RRM2,TNFSF14 15 (7) 6 ZFTA-RELA CISH,RPSA ddATP chemical drug 3 1.633 1.46E-03 3.00E-02 Akt,AKT1,ddATP,GABARAPL2,IKBKB,IKBKE,IRF3,Jnk,JUN,MAPK8,MAPT,NFkB (complex),NFKB1,NFKBIA,REL,STING1,TBK1 AGA,AIMP2,ALDH7A1,ANOS1,ASPG,B4GALT1,BIRC2,BIRC3,CGAS,CLEC10A,DGAT1,GNAO1,HNRNPM,IFI44,L1CAM,LGMN,LITAF,MATR3,NCAN,PGK1,POLI,SERINC2,SOD3,TNFSF14 24 (17) 16 ciprofloxacin chemical drug 2 0.302 1.47E-03 4.70E-03 ciprofloxacin,CYP1A2,ERK1/2,MMP2 ACAA1,ANGPT2,AOC1,BIRC2,BIRC3,CACHD1,EMILIN2,GSTM3,ITGB3,LGMN,PLG 11 (4) 4 CASP3,CD93,CTSA,GRN,PKN2,prostaglandin E2 fludarabine phosphate chemical drug 3 -0.209 1.48E-03 2.25E-02 Akt,BCL2,cytarabine,DCK,ERK1/2,fludarabine phosphate,FOXM1,gemcitabine,HIF1A,Jnk,NFkB (complex),P38 MAPK,RRM2,SNAI1 AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,GLB1,ITGB3,KRT8,PGK1,PLG,PPP1CA,SLC16A4,SNAP25,SOD3,TMPRSS6,TNFSF14 23 (14) 11 RRM2 ATP2B2 transporter 0.000 2 Activated 2.449 1.48E-03 4.40E-03 ATP2B2,EIF2AK3 BIRC2,BIRC3,FLNC,PNLIP,RAB11A,SOD3 6 (2) 2 nifedipine HIPK2,SOD3 Ca2+,KIT,RPL22 G protein complex 2 -0.378 1.48E-03 3.64E-02 Akt,CFTR,cyclic AMP,EGF,ERK1/2,G protein,G protein alphai,GNA12,GNAS,GNB3,INSR,Jnk,Mmp,NFkB (complex),P38 MAPK,PI3K (complex),PIK3CG,PTK2 ACAA1,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,CUBN,DGAT1,FCGBP,FLNC,GNAO1,HSD3B2,KRT8,L1CAM,LITAF,NCAN,PLG,PPP1CA,RRM2,SNAP25,SOD3,TNFSF14 28 (18) 17 [D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin,BDKRB2,cannabinoid receptor,CX3CL1,FPR1,NPY,WNT5A,ZP3 Beta Arrestin,RGS4 Ca2+,NFkB (complex),Pak,PIK3CG,PLCB3 DOK1 kinase 2 1.877 1.49E-03 2.08E-02 AKT1,DOK1,ERK,ERK1/2,HRAS,MAPK1,Mek,Nfat (family),NRAS,RAF1,STAT4 ADGRG6,ANGPT2,AOC1,BIRC2,BIRC3,CALCRL,CASP2,CEBPD,Cyp2d22,FASN,FLNC,HNRNPM,IFI44,ITGB3,MATR3,PLG,PTPRK,RRM2,SLC16A7,TENM3,TNFSF14,TULP4,VPS25 23 (11) 10 AKT1,RASA1 GRM5 G-protein coupled receptor -0.000 2 -1.789 1.50E-03 1.64E-02 Akt,CNR1,ERK,ERK1/2,GRM5,MAPK1,MAPK3,P38 MAPK,Pkc(s),SRC (family) ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,FASN,FLNC,IFI44,ITGB3,KRT8,L1CAM,LRP4,PLG,PTPRK,RRM2,TNFSF14 20 (10) 9 cocaine miR-128-3p (and other miRNAs w/seed CACAGUG),pilocarpine,SIAH1 PPARA ligand-dependent nuclear receptor 2 1.219 1.52E-03 4.30E-02 ABCB4,Ap1,CEBPA,CYP19A1,ERK1/2,HNF4A,JUN,MMP2,MMP9,NFkB (complex),P38 MAPK,PPARA,PPARG,RB1,SMAD4,STAT5B,TERT ABCA3,ACAA1,ALDH7A1,ANK1,AOC1,ASPG,B4GALT1,CALCRL,CALM1 (includes others),CASP2,CEBPD,CELSR1,CGAS,CYP39A1,DGAT1,EMX2,FASN,FUT6,GLB1,GSTM3,H2BC21,HSD3B2,IFI44,L1CAM,LITAF,MAPK4,PLG,PLIN2,POLI,PTPRK,RRM2,SERINC2,SOD3 33 (17) 17 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine,14,15-epoxyeicosatrienoic acid,8(S)-hydroxyeicosatetraenoic acid,acetyl-L-carnitine,Ca2+,cerivastatin,chenodeoxycholic acid,DBP,delta-tocotrienol,EP300,ERN1,farnesol,IgG,indomethacin,leucine,leukotriene B4,LPIN1,oleic acid,PPP3R1,prostaglandin A1,prostaglandin A2,PTN,RXRA,SOCS3,taurocholic acid,telmisartan,TFAM AKT1,Hsp90,miR-217-5p (and other miRNAs w/seed ACUGCAU),N-cor,PLCL1,POU5F1,SAR1B,SLC2A1,SOST,tributyltin,tunicamycin,XDH ACADS,ACSL1,ADAM10,ANGPTL4,CDKN2A,DIO1,DIO2,HMOX1,HSD17B4,mir-182,miR-182-5p (and other miRNAs w/seed UUGGCAA),miR-34a-5p (and other miRNAs w/seed GGCAGUG),MMD,PC,S100A9,SCP2,TJP1,tyrosine kinase bile acid,CCNE1,CD63,CYP2B6,SAA,TERT,VLDL exemestane chemical drug 2 -1.134 1.52E-03 3.10E-03 CYP19A1,exemestane,HMOX1 ANGPT2,ANGPTL3,ASPG,FASN,ITGB3,PLIN2,TNFSF14 7 (3) 2 HMOX1 CD63 other 0.000 3 0.590 1.53E-03 4.23E-02 ACHE,Akt,Alpha catenin,AR,CD63,CDKN1B,CTNNB1,DLX5,ERK,ERK1/2,ESR2,ETS2,GRIN3A,HIF1A,HRAS,IL10,IRF3,KDR,MITF,NEDD9,NGEF,NR1I3,NRAS,PGR,PKD1,PLC gamma,PPARA,PPARGC1A,PTK2,PTPRJ,RB1,RUNX3,RXRA,SIRT1,SNCA,SRC,STAT5B,STK11,TWIST1,WBP2,WWOX ADGRG6,ADRM1,AIMP2,ANGPT2,ANGPTL3,ANOS1,AOC1,BBX,BIRC2,BIRC3,C1QTNF3,CEBPD,CHAC1,CLPB,CR1,Cyp2d22,CYP39A1,EMILIN2,FAT4,FCGBP,GSTM3,HCRTR2,L1CAM,MAPK4,MEGF10,MEGF11,MKX,PGK1,PIF1,PLG,POU3F3,RRM2,RRP12,SCARF1,SLC16A4,SLC5A7,SUSD2,SVEP1,TENM3,TMPRSS6,TNFSF14,TPPP3,TRIM2,TRIM3,TULP4,VPS25 46 (41) 39 IL27,POU5F1,PPARA,quercetin,SRT2104 PLC gamma DGCR8 enzyme -0.000 2 -1.147 1.53E-03 1.24E-02 Akt,DGCR8,ERK1/2,FOS,MITF,NFATC1,SPI1 ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CD209,FASN,HSD3B2,IFI44,ITGB3,KIFC1,KRT8,L1CAM,NUBP1,PIF1,PLG,RRM2,TNFSF14 19 (7) 7 HMOX1 CNN1,PMP22 AR-12 chemical drug 2 Activated 2.496 1.55E-03 7.80E-03 Akt,AKT1,AR-12,CDKN1B,p70 S6k,PDPK1 AIMP2,BIRC2,BIRC3,CEBPD,CLPB,FASN,HNRNPM,L1CAM,MATR3,PLG,RAB11A,RRM2,TNFSF14 13 (6) 5 AKT1,RPS6KB2 DLX5 transcription regulator 3 0.200 1.55E-03 3.24E-02 Akt,C/EBP,CDK2,CEBPA,DLX5,EGFR,HIF1A,Jnk,NOTCH1,RB1,RUNX2,SREBF1,VitaminD3-VDR-RXR ABCA3,AIMP2,ANGPT2,CALCRL,CD209,CEBPD,CELSR1,CLEC10A,DPY19L3,EMX2,GLB1,H2BC21,ITGB3,KRT8,LITAF,LRP5,MAPK4,MMRN1,PLIN2,POU3F3,PTPRK,SLC16A4,SNAP25,TNFSF14,TNXB 25 (13) 12 GDF2 EBF1 phorbol 12,13-dibutyrate chemical - endogenous non-mammalian 2 -0.209 1.56E-03 2.22E-02 Akt,Ap1,ERK1/2,INSR,Jnk,MAPK1,MAPK3,phorbol 12,13-dibutyrate,Pkc(s),PSEN1,RAF1,SPHK1,SRC (family),TERT AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CALM1 (includes others),CD209,CLEC10A,DGAT1,FCGBP,FLNC,GLB1,HSD3B2,ITGB3,KRT8,L1CAM,PLG,PTPRK,RRM2,SLC16A7,TNFSF14,TNXB 23 (14) 14 IBSP,LRP6,MAP3K8,MDM2,RRM2,SPHK1,TERT Ca2+,CCND2,PTAFR MFAP5 other 2 -1.387 1.57E-03 7.60E-03 Akt,MFAP5,NOTCH1,PI3K (family) AIMP2,BIRC2,BIRC3,COLEC11,FASN,ITGB3,KRT8,L1CAM,PGK1,PLG,PTPRK,RRM2,TNFSF14 13 (4) 4 PD173074,PGR CDH2,MFAP2,MRAS,TFPI ANGPT4,UBE2C KIT transmembrane receptor 2 -1.177 1.58E-03 3.07E-02 Akt,AKT1,ERK1/2,GAB2,GRB2,JAK,Jnk,KIT,MAPK1,MAPK8,Mek,MITF,P38 MAPK,PI3K (complex),PTPN11,RAF1,SRC,STAT,STAT1 ABCA3,AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,EMX2,FLNC,HNRNPM,IFI44,ITGB3,KIFC1,L1CAM,MATR3,PGK1,PIF1,PLG,PTPRK,RRM2,SLC16A7,TNFSF14 26 (19) 18 8-bromo-cAMP,deferoxamine,INHA,NFkB (complex),PGF,phytohemagglutinin,TFAP2B,tyrosine kinase,WNT3A,WNT5A AKN-028,ATP2B2,BHLHE40,DAB2IP,ESR2,huaier extract granule,mir-154,MIR17HG,NOX4,OSI-930,retaspimycin,tanespimycin,vatalanib AKT1,MAPK7,p85 (pik3r),PLC gamma CCND2,ceramide carbon monoxide chemical - endogenous mammalian 2 0.392 1.62E-03 3.23E-02 Akt,Ap1,carbon monoxide,CDK2,EIF2AK3,ERK,ERK1/2,HMOX1,Jnk,MAPK1,MAPK3,PPARG,RB1,STAT3 ACAA1,ADGRG6,AIMP2,ANGPTL3,AOC1,B4GALT1,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CLEC10A,DGAT1,FASN,FLNC,H2BC21,IFI44,L1CAM,MAPK4,PGK1,PLG,PLIN2,PNLIP,PTPRK,RRM2,SNAP25 26 (14) 13 hydrogen sulfide,linsidomine NFkB (complex),NOX4,sGC CASP3,leukotriene B4 KT5823 chemical - kinase inhibitor 2 Activated 2.887 1.65E-03 3.10E-02 Akt,AKT1,CHUK,Creb,CREB1,ERK,ERK1/2,IKBKB,KT5823,MAPK1,MAPK14,P38 MAPK,RAF1,SLC6A4 ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CEBPD,DPY19L3,FLNC,GNAO1,HNRNPM,IFI44,ITGB3,KRT8,L1CAM,LITAF,LRP6,MATR3,MGAT4C,PLG,PTPRK,RRM2,SERINC2,SLC16A7,SOD3,TNFSF14 27 (14) 13 CASP3,ITPR1,Na+,K+ -ATPase AKT1,Ca2+,CNN1,CNTF,SLC2A1 BHLH group 2 1.667 1.66E-03 8.40E-03 BHLH,BHLHA15,BHLHE40 ALDH7A1,CALCRL,FASN,GSTM3,KRT8,PGK1,PLIN2,REG1A,SCARF1 9 (3) 2 USP44 peptidase 3 1.915 1.66E-03 4.97E-02 BCL2L1,CDC20,cytokine,E2F1,FOXP3,FSH,H2AB3 (includes others),H2AZ1,Hdac,Histone h2a,IL17A,MACROH2A1,Nfat (family),NFkB (complex),RASSF1,RORA,RORC,RUNX1,SETD2,TP53,USP44 ADAMTS16,ALDH7A1,ANGPT2,ANGPTL3,B4GALT1,BIRC2,BIRC3,CALCRL,CASP2,CD209,CEBPD,CELSR1,CHAC1,CSMD3,DUT,EMX2,FASN,FAT4,FLNC,HSD3B2,KIFC1,LITAF,LRP4,MAPK4,PGK1,PLG,PLIN2,PPP1CA,RRM2,SNAP25,SOD3,TNFSF14,TSG101 33 (21) 17 Histone h2a PPARD ligand-dependent nuclear receptor 0.000 2 0.000 1.66E-03 4.85E-02 Akt,AKT1,CTNNB1,ERK1/2,FOXO1,NFkB (complex),NFKBIA,PAK2,PPARA,PPARD,PPARG,RAF1,SIRT1,STAT3 ACAA1,AIMP2,ALDH7A1,ANGPTL3,AOC1,B4GALT1,CASP2,CD209,CEBPD,CLEC10A,CYP39A1,DGAT1,EMX2,FCGBP,GSTM3,HCRTR2,HNRNPM,ITGB3,KIFC1,KRT8,LITAF,MATR3,NCAN,PGK1,PLIN2,SERINC2,SLC16A7,SOD3,SUSD2,TNFSF14,TSG101,WRN 32 (14) 14 12(S)-hydroxyeicosatetraenoic acid,8(S)-hydroxyeicosatetraenoic acid,8-bromo-cAMP,anandamide,delta-tocotrienol,linsidomine,PD173074,prostaglandin A1,prostaglandin A2 indomethacin,N-cor,NCOA3,PLCL1 AKT1,CCNE1,CYP2B6,MAP3K7,MDFI,MERTK,MOG,NFkB (complex),oleic acid,PAK2,PDK1,RASGRP1,RBP1 ANGPTL4,CASP3,CCL3L3,CCND2,CLEC7A,GPAM,IGFBP6,IgG,Irgm1,NPY,TFF2,VLDL 8-(4-chlorophenylthio)-guanosine-3', 5'-cyclic monophosphate chemical reagent 2 -1.528 1.67E-03 1.73E-02 8-(4-chlorophenylthio)-guanosine-3', 5'-cyclic monophosphate,Akt,Creb,ERK,ERK1/2,MAPK1,MAPK14,MAPK8,RAF1 ADGRG6,AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,DGAT1,DPY19L3,FASN,FLNC,IFI44,ITGB3,L1CAM,LRP6,PLG,PTPRK,RRM2,SLC16A7,TNFSF14 21 (9) 8 cyclic ADP-ribose,LASP1 Ca2+,CCL3L3 INPP4B phosphatase 2 Activated 2.309 1.68E-03 5.30E-03 Akt,AKT1,INPP4B,PRKCB,PRKCZ AIMP2,BIRC2,BIRC3,CASP2,CEBPD,FASN,HNRNPM,L1CAM,MATR3,PLG,RRM2,TNFSF14 12 (5) 4 N-cor ESR2 AKT1 ITPR1 ion channel 0.000 2 0.500 1.70E-03 1.42E-02 Ca2+,Creb,ERK1/2,ITPR1,Jnk,NFATC2,NOS3,PNPLA2 ANGPT2,AOC1,BBX,BIRC2,CD209,CEBPD,CLEC10A,DPY19L3,ITGB3,KRT8,PLG,PLIN2,PTPRK,RRM2,SOD3,TSG101 16 (8) 7 8-bromo-cAMP,EPAS1,KT5823,L-triiodothyronine benzo(a)pyrene,NFkB (complex),PPP1CA,SOCS3,tacrolimus CAMK2,CASP3 Histone h2a group 2 0.000 1.70E-03 6.30E-03 AURKB,FSH,H2AB3 (includes others),H2AZ1,Histone h2a,MACROH2A1,SETD2 ADAMTS16,ANGPTL3,ANK1,CHAC1,FASN,FLNC,HSD3B2,MAPK4,PLG,SNAP25 10 (7) 6 AKT1,etoposide,USP44 BCOR,MK2206,PCGF1,RYBP,UBR2 SETD2 FGFR3 kinase 2 -1.706 1.70E-03 2.19E-02 Akt,CHRNA7,ERK,ERK1/2,FGFR2,FGFR3,MAPK1,MAPK3,nitric oxide,PI3K (complex),Pkc(s),RAS,STAT,STAT3 ADGRG6,AIMP2,ANGPT2,AOC1,B4GALT1,BIRC3,CD209,CEBPD,CHRNA10,CUBN,FASN,FLNC,IFI44,KRT8,L1CAM,PGK1,PLG,PTPRK,RRM2,SLC16A4,TENM3,TNFSF14 22 (14) 13 FGF19,GDF2,Hsp90,liraglutide,phytohemagglutinin,PROX1 benzo(a)pyrene,dovitinib,PD173074 diquat chemical toxicant 2 -0.905 1.71E-03 2.80E-03 diquat,ERK1/2,Jnk,MAPK9 ANGPT2,AOC1,BIRC2,BIRC3,CD209,CLEC10A,FASN,ITGB3,PLG,PLIN2,SOD3 11 (4) 3 CASP3,HMOX1 PAK3 kinase 2 -1.500 1.72E-03 1.02E-02 Jnk,MAP2K1,MAP3K1,MAPK14,MAPK8,MAPK9,MYO6,P38 MAPK,PAK3,RAF1 ANK1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,ITGB3,LRP6,NLGN2,PLG,PLIN2,RRM2,SLC16A7,SOD3 16 (10) 9 FRAX-597 D-fructose chemical - endogenous mammalian 2 0.000 1.73E-03 8.60E-03 Akt,D-fructose,IRS1,SIRT1 AIMP2,BIRC2,BIRC3,CEBPD,CLEC10A,FASN,HCRTR2,IFI44,L1CAM,PLG,RRM2,SOD3,TNFSF14,TSG101 14 (4) 4 oxonic acid CXCL10,fatty acid,IRS1,SCD LPXN transcription regulator 2 1.387 1.74E-03 8.20E-03 Akt,LPXN,MAPK14,MAPK8,MAPK9 AIMP2,B4GALT1,BIRC2,BIRC3,CEBPD,DGAT1,L1CAM,LRP6,PLG,PLIN2,RRM2,SOD3,TNFSF14 13 (5) 4 NOX4 enzyme 2 0.000 1.75E-03 4.42E-02 AKT1,ERK,ERK1/2,INSR,Jnk,MAPK1,MAPK3,NFE2L2,NOX4,P38 MAPK,PDPK1,RB1,SRC,STAT3 ADGRG6,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CALCRL,CD209,CELSR1,CLEC10A,DGAT1,FCGBP,FLNC,H2BC21,HNRNPM,HSD3B2,IFI44,L1CAM,MAPK4,MATR3,PGK1,PLG,PLIN2,PTPRK,RAB11A,RRM2,SOD3 28 (14) 13 avexitide,carbon monoxide,ERN1,HNF4A,leukotriene B4,PAK2,PLA2G6,SATB2,SOST 3-deazaneplanocin,BTG2,CBLC,CDKN2A,mefunidone,zoledronic acid EPAS1,GSTA1,HAS2,PDK1,radical,RPS6KB1,SLC2A1,TJP1 KIT,TFAM asiatic acid chemical reagent 3 0.539 1.75E-03 4.94E-02 26s Proteasome,Akt,AKT1,Ap1,AR,asiatic acid,BCL2,benzo(a)pyrene,CASP9,CYP2C9,ERK,ERK1/2,Hif1,IKBKB,Jnk,MAPK1,Mek,NFKBIA,PAK2,RB1,SOX9,SP1,TERT ADGRG6,ADRM1,AIMP2,ANGPT2,AOC1,CALCRL,CALM1 (includes others),CASP2,CD209,CELSR1,CLEC10A,Cyp2d22,FLNC,GLB1,GNAO1,H2BC21,HNRNPM,HSD3B2,ITGB3,KRT8,L1CAM,LITAF,LRP6,MAPK4,MATR3,NCAN,PGK1,PTPRK,SNAP25,TNFSF14,WRN 31 (23) 20 PDK1 kinase 3 -0.632 1.78E-03 3.53E-02 Akt,AKT1,AKT2,APP,ATF4,DLX5,EIF4E,ERK1/2,FMR1,FOS,Gsk3,GSK3B,IL10,IRF3,LGALS3,MAFB,MITF,MYB,NFATC2,NGEF,NR1I3,PDK1,PDPK1,PPARGC1A,PRKCB,RICTOR,RPS6KA3,RPS6KB1,SOX2,SPARC,TNF,TNFSF11,TWIST1,VDR AIMP2,ANGPT2,ANOS1,AOC1,BBX,C1QL1,CEBPD,CHAC1,CR1,CUBN,CYP39A1,EMILIN2,FASN,FAT4,FRRS1,HNRNPM,ITGB3,L1CAM,LRP4,MATR3,NLGN2,NUBP1,PIF1,PLG,POU3F3,PRKCSH,PTGIR,RAB11A,RRM2,RSL24D1,SCARF1,SVEP1,SYCE2,THSD4,TNFSF14,TNR,TPPP3,TRIM2,TRIM56,TULP4 40 (34) 29 NOX4,PIK3CA,PPARD,TINCR HNF4A,MK2206,SENP2 PKN2,RPS6KB1,VAV1 HSBP1 other 0.000 2 1.155 1.78E-03 6.20E-03 DUSP1,ERK1/2,HSBP1,HSF1 ANGPT2,AOC1,BIRC2,BIRC3,CELSR1,CLEC10A,FASN,IFI44,ITGB3,PGK1,PLIN2,PTPRK 12 (4) 3 anandamide,MAP2K2 ATP7A transporter -0.000 3 -0.186 1.79E-03 4.29E-02 ATP7A,CHUK,CP,Creb,CTNNB1,EGFR,EIF4E,ERK,ERK1/2,IKBKB,Jnk,LOX,MAPK1,MAPK3,MDM2,Mek,NFkB (complex),NOS3,PLA2G2A,PLA2G4A,RAS,SOD3 ACAA1,ADGRG6,ALDH7A1,ANGPT2,AOC1,ASPG,B4GALT1,BIRC2,CASP2,CD209,CLEC10A,DPY19L3,EMX2,FLNC,H2BC21,IFI44,KIFC1,KRT8,NLGN2,PGK1,PLG,PLIN2,PTPRK,RRM2,SOD3,SUSD2,TNXB,TSG101,WRN 29 (22) 17 HNF4A MIR17HG SOD3 DIABLO other 1 1.414 1.80E-03 2.20E-03 DIABLO BIRC2,BIRC3 2 (1) 1 CASP3,caspase HCFC1 transcription regulator 0.000 1 0.000 1.80E-03 5.30E-03 HCFC1 FASN,KMT5A 2 (1) 1 EP300,GAST phytohemagglutinin SLC25A4 transporter 1 0.000 1.80E-03 2.20E-03 SLC25A4 BIRC3,CLPB 2 (1) 1 ammonium daunorubicin NFkB (complex) Vhl complex 1 1.414 1.80E-03 4.30E-03 Vhl BIRC2,BIRC3 2 (1) 1 NFkB (complex) nimbolide chemical - endogenous non-mammalian 1 1.414 1.80E-03 1.50E-03 nimbolide BIRC2,BIRC3 2 (1) 1 NFkB (complex) SH3BP2 other -0.000 2 -1.606 1.83E-03 1.60E-02 Akt,AKT1,ERK,ERK1/2,Jnk,NFATC2,SH3BP2,STAT1 ADGRG6,AIMP2,ANGPT2,AOC1,BBX,BIRC2,CASP2,CD209,CEBPD,CLEC10A,FASN,HNRNPM,ITGB3,L1CAM,MATR3,PLG,PTPRK,RRM2,TNFSF14 19 (8) 8 CDKN2A AKT1,PLC gamma propofol chemical drug 2 -0.728 1.84E-03 1.13E-02 Akt,CYP1A2,ERK,GRIN3A,Hif1,Jnk,MAPT,NOS3,propofol ADGRG6,AIMP2,ASPG,BIRC2,BIRC3,CACHD1,CD209,CEBPD,CLEC10A,GSTM3,HCRTR2,L1CAM,PGK1,PLG,RRM2,SOD3,TNFSF14 17 (9) 8 Ca2+,HMOX1 CASP3,leukotriene B4,NET1,peroxynitrite,SOD1 CRKL kinase 2 -1.606 1.88E-03 1.62E-02 Akt,BCR-ABL1,CRKL,ERK,HRAS,MAPK1,MAPK3,MAPK8 ADGRG6,AIMP2,B4GALT1,BIRC2,BIRC3,CALCRL,CEBPD,DGAT1,FASN,FLNC,IFI44,ITGB3,L1CAM,PGK1,PLG,PTPRK,RRM2,TENM3,TNFSF14 19 (8) 7 aminoxyrone CXCL10,IFNB1,RAPGEF1,Sapk,VAV1,YES1 COPS6 other 0.000 2 0.302 1.89E-03 7.00E-03 Akt,COP1,COPS6,MDM2,SFN AIMP2,BIRC2,CASP2,H2BC21,KRT8,L1CAM,PLG,SYT12,TNFSF14,TSG101,WRN 11 (5) 4 MDM2 ghrelin biologic drug 2 -1.155 1.89E-03 5.60E-03 Akt,ERK1/2,ghrelin,NOS3 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,FASN,ITGB3,L1CAM,PLG,RRM2,SOD3,TNFSF14 12 (4) 4 SCD MALP-2s chemical reagent 2 -0.655 1.90E-03 1.98E-02 Akt,ERK1/2,Jnk,MALP-2s,MAPK14,MAPK8,NFkB (complex),NFKB1,P38 MAPK,RELA AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FASN,GNAO1,ITGB3,L1CAM,LRP6,PLG,RRM2,SOD3,TNFSF14 21 (10) 9 CAMP,CCL3L3,CYP27B1,NFkB (complex) OPRK1 G-protein coupled receptor -0.000 2 -0.905 1.92E-03 3.70E-03 ERK1/2,Jnk,MAPK14,OPRK1 ANGPT2,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,ITGB3,LRP6,PLG 11 (4) 3 [D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin,GABARAP,GABARAPL1,nor-binaltorphimine Beta Arrestin,GRK2,linsidomine,U 50488H BMP7 growth factor -0.000 2 0.688 1.92E-03 1.97E-02 ACVRL1,Ap1,BMP7,CDK2,ERK1/2,Jnk,MAPK8,P38 MAPK,RB1,SMAD3,TGFBR1 ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CLEC10A,DGAT1,FASN,H2BC21,MAPK4,PLG,PTPRK,RRM2,SNAP25 19 (11) 11 8-bromo-cAMP,CASR,LIF BCOR,HNF4A,MMP7,MSTN AKT1,IBSP,IRS1,NPHS1,PENK,SOSTDC1,TFAM,WNT3A ACSL1,CASP3,HSPB1,IGFBP6,SOCS3 TFF2 other 2 -1.604 1.94E-03 8.10E-03 Akt,ERK,ERK1/2,Jnk,TFF2 ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,L1CAM,PLG,RRM2,TNFSF14 14 (5) 4 WNT1 BHLHE40,CDX1,PPARD CCND2,CCNE1 aplidine biologic drug 2 -0.229 1.96E-03 1.63E-02 Ap1,aplidine,CYP1A2,EGFR,Jnk,MAPK8,NFkB (complex),P38 MAPK,SRC ALDH7A1,ANK1,B4GALT1,BIRC2,BIRC3,CACHD1,CALM1 (includes others),CD209,CEBPD,CLEC10A,DGAT1,FASN,GSTM3,ITGB3,PGK1,PLG,RRM2,SOD3,TNXB 19 (9) 8 NFkB (complex) pentobarbital chemical drug 2 1.069 1.97E-03 9.30E-03 Calcineurin protein(s),ERK1/2,Jnk,MAPT,NFATC2,P38 MAPK,pentobarbital ANGPT2,ANK1,AOC1,ASPG,BBX,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG,PTPRK,TSG101 14 (7) 6 CYP2B6 Ca2+ Sik1 kinase 3 0.000 1.98E-03 1.72E-02 Ap1,CRTC1,GATA1,HDAC5,Jnk,MEF2,MEF2A,MEF2D,MYOD1,PPARA,Sik1 ACAA1,ANK1,BIRC3,CALM1 (includes others),CD209,CEBPD,CLEC10A,DUT,FASN,GSTM3,IFI44,ITGB3,Lgals6,PLG,PLIN2,RRM2,SERINC2,SOD3 18 (11) 8 cocaine,forskolin MIR17HG,prazosin CRTC1,DIO2 BIIE 0246 chemical reagent 2 -0.258 1.99E-03 1.24E-02 Akt,BIIE 0246,ERK1/2,FOS,MAPT AIMP2,ANGPT2,AOC1,ASPG,BIRC2,BIRC3,FASN,HSD3B2,ITGB3,KRT8,L1CAM,NUBP1,PLG,RRM2,TNFSF14 15 (5) 4 AHNAK,RAPGEF3 LRRK2 kinase 0.000 2 Inhibited -2.000 2.00E-03 1.00E-02 AKT1,CASP1,HIF1A,LRRK2,MAPT,MET,Nfat (family) ASPG,B4GALT1,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,ITGB3,L1CAM,MATR3,PGK1,PLG,RRM2,SLC16A4,TMPRSS6,TNFSF14 16 (7) 6 CSNK1D Notch,PPP1CA AKT1 ADAM10 peptidase -0.000 2 -0.447 2.00E-03 2.39E-02 ADAM10,APP,EGFR,ERK1/2,MDM2,MET,Notch,P38 MAPK,Ras homolog ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CASP2,CEBPD,CLEC10A,FASN,GSTM3,H2BC21,ITGB3,LRP6,POU3F3,RRM2,THSD4,TNXB,TPPP3,TSG101,WRN 20 (9) 8 Ca2+,cryptotanshinone,etoposide,huperzine A,INS,PPARA,tunicamycin,WNT3A aderbasib,DETA-NONOate,L-triiodothyronine,rhesus theta-defensin 1,rhesus theta-defensin 2,rhesus theta-defensin 3,SALL4 CDH2,ICOS,MDM2,Notch,S100A9,SAA1 CDH5,PEA15 CDN1163 chemical reagent 2 1.265 2.00E-03 6.70E-03 CDN1163,EIF2AK3,ERN1,Jnk BIRC2,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FASN,PLG,PLIN2,PNLIP 10 (4) 4 Ca2+ ERN1,HNF4A,SCD PROX1 transcription regulator 0.000 2 -0.905 2.01E-03 5.70E-03 Akt,NR5A2,PROX1 AIMP2,ANGPT2,BIRC2,CEBPD,FASN,HSD3B2,L1CAM,PLG,PNLIP,RRM2,TNFSF14 11 (3) 3 HAS2,VEGFC GDF2,PAK2 CCNE1,FGFR3 NR5A2,RGS4 EBF1 transcription regulator 0.000 2 -1.147 2.02E-03 1.94E-02 Akt,CEBPA,EBF1,EP300,ERK1/2,IRS1,STAT1 ABCA3,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CASP2,CEBPD,EMX2,FASN,ITGB3,L1CAM,LITAF,MMRN1,PGK1,PLG,PLIN2,RRM2,TNFSF14 19 (7) 6 CBLC,CXCL10,IFNB1,IRS1,PIK3CA,PIK3CD,RPS6KB1 DLX5,EP300 N-acetylmuramyl-L-alanyl-D-isoglutamine chemical - endogenous non-mammalian 2 -0.200 2.03E-03 3.58E-02 CTNNB1,ERK,ERK1/2,IFNAR1,IRF3,Jnk,JUN,MAPK3,MMP9,N-acetylmuramyl-L-alanyl-D-isoglutamine,NFkB (complex),NFKBIA,P38 MAPK,RIPK2 ACAA1,ADGRG6,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,B4GALT1,CD209,CGAS,CLEC10A,DGAT1,EMX2,IFI44,ITGB3,KIFC1,KRT8,L1CAM,LITAF,NCAN,PGK1,PLG,PLIN2,POLI,SUSD2 25 (14) 14 FZD4,NFkB (complex),prostaglandin E2,WNT3A nor-binaltorphimine chemical reagent 2 1.265 2.04E-03 6.00E-03 ERK1/2,Jnk,MAPK14,nor-binaltorphimine ANGPT2,AOC1,BIRC2,CD209,CEBPD,CLEC10A,FASN,ITGB3,LRP6,PLG 10 (4) 3 Ca2+,OPRK1 MAX-40279 chemical drug 3 0.928 2.06E-03 4.79E-02 Akt,CHEK1,Creb,ERK,ERK1/2,FGFR,FGFR2,FGFR4,FLT3,GRB2,MAPK1,MAPT,MAX-40279,Mek,NR3C1,P38 MAPK,Pkc(s),PPARG,PTPN11,RAS,RUNX2,STAT,STAT3,STAT5A ABCA3,ACAA1,ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,ASPG,B4GALT1,BIRC2,CASP2,CD209,CEBPD,CUBN,DGAT1,DPY19L3,EMX2,FLNC,HSD3B2,ITGB3,KRT8,L1CAM,PGK1,PLG,PLIN2,PTPRK,RRM2,TENM3,TNFSF14 29 (24) 21 USP18 peptidase 2 1.342 2.08E-03 2.12E-02 JINK1/2,MAP3K7,Nfat (family),NFATC1,NFATC2,NFkB (complex),NFKB1,P38 MAPK,REL,RELA,STAT,STAT1,TAB1,USP18 AGA,ALDH7A1,ANGPT2,ANK1,B4GALT1,BBX,BIRC2,BIRC3,CASP2,CD209,CEBPD,DUT,FASN,GNAO1,IFI44,ITGB3,PLG,PTPRK,SOD3,TNFSF14 20 (14) 13 POU5F1,S100A9 birabresib,forskolin,Irgm1,ziritaxestat CCL3L3,CXCL10,JINK1/2,Map3k7,NFkB (complex),SOCS3 USP2 peptidase 0.000 2 1.213 2.08E-03 1.65E-02 EGFR,MAP3K1,MDM2,MDM4,NFkB (complex),TWIST1,USP2 ALDH7A1,B4GALT1,BIRC2,BIRC3,CASP2,CEBPD,CELSR1,FASN,FAT4,FCGBP,H2BC21,ITGB3,KRT8,SOD3,TNXB,TSG101,WRN 17 (7) 6 PPP3R1 MDM2,NFkB (complex) Arg-Gly-Asp chemical reagent 3 -0.781 2.09E-03 4.38E-02 ACHE,AGT,Akt,Arg-Gly-Asp,CASP3,CEBPA,COP1,DICER1,DLX5,EGFR,ERK,ESR2,Focal adhesion kinase,IGF1,IRF3,MITF,MYB,NEDD9,NFATC2,NGEF,P38 MAPK,PPARGC1A,RB1,RXRA,S100A9,SIRT1,STAT5B,TWIST1,WBP2 ADGRG6,ADRM1,AIMP2,ANGPTL3,ANK1,ANOS1,ATL2,BBX,BCHE,BIRC2,CR1,CYP39A1,EMILIN2,FASN,FAT4,FCGBP,HCRTR2,ITGB3,KRT8,L1CAM,LRP5,MAPK4,MEGF10,MMRN1,PIF1,PLG,PNLIP,POU3F3,REG1A,RRM2,RRP12,SCARF1,SLC5A7,SSPOP,SVEP1,SYT12,THSD4,TNFSF14,TNXB,TPPP3,TULP4 41 (29) 28 CASP3 Focal adhesion kinase 19,20-epoxydocosapentaenoic acid chemical - endogenous mammalian 2 0.000 2.10E-03 5.50E-03 19,20-epoxydocosapentaenoic acid,ERN1,GSK3B,KDR,MMP2 ANGPT2,BIRC2,BIRC3,CEBPD,DGAT1,FASN,PLG,PLIN2 8 (5) 4 ERN1,ZEB2 guanosine chemical - endogenous mammalian 2 -0.258 2.12E-03 1.40E-02 Akt,ANXA7,Creb,guanosine,MAPK8,NR4A2,P38 MAPK AIMP2,ANK1,B4GALT1,BIRC2,BIRC3,CEBPD,DGAT1,DPY19L3,HSD3B2,ITGB3,L1CAM,PLG,RRM2,TNFSF14,TSG101 15 (7) 6 HMOX1 cyclic ADP-ribose chemical - endogenous mammalian 3 Inhibited -2.673 2.13E-03 9.00E-03 AKT1,ATF6,Creb,cyclic ADP-ribose,ERK1/2,RYR2,TRPM2 ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,DPY19L3,FASN,HNRNPM,ITGB3,KRT8,MATR3,PLG,PLIN2,RRM2 14 (7) 5 8-(4-chlorophenylthio)-guanosine-3', 5'-cyclic monophosphate,acetylcholine Ca2+,TRPM2 RGL1 other 3 1.789 2.14E-03 2.62E-02 AKT1,EIF2AK2,MAPK1,MAPK3,PPP1CA,RAF1,RB1,RGL1,TAFAZZIN ADRM1,ANGPT2,B4GALT1,BIRC2,BIRC3,CALCRL,CEBPD,CELSR1,FASN,FLNC,H2BC21,HNRNPM,ITGB3,MAPK4,MATR3,PLG,PPP1CA,PTPRK,RRM2,SLC16A7 20 (9) 8 TRIB1 GPS2 PPP1CA prostaglandin A1 chemical - endogenous non-mammalian 2 -0.200 2.14E-03 3.42E-02 ERK,ERK1/2,IKBKB,Jnk,NFkB (complex),NFKBIA,P38 MAPK,PPARA,PPARD,PPARG,prostaglandin A1,STK11 ACAA1,ADGRG6,ALDH7A1,ANGPT2,ANGPTL3,ANK1,AOC1,B4GALT1,CD209,CLEC10A,CYP39A1,DGAT1,DUT,FASN,FCGBP,GSTM3,LITAF,NCAN,PGK1,PLG,PLIN2,RRM2,SERINC2,SLC16A4,SOD3 25 (12) 11 CASP3,HMOX1,Hsp90,PPARA,PPARD NFkB (complex) EXT1 enzyme 0.000 2 -1.732 2.17E-03 7.30E-03 Akt,ERK1/2,EXT1,IRS AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,DGAT1,ITGB3,L1CAM,PLG,RRM2,TNFSF14 12 (4) 4 BHLHE40 LRP6 IRS E2F2 transcription regulator 2 Inhibited -2.324 2.17E-03 1.04E-02 Akt,CDK2,E2F2,ERK,RB1 ADGRG6,AIMP2,ANGPT2,BIRC2,CALCRL,CEBPD,CELSR1,H2BC21,ITGB3,L1CAM,MAPK4,PLG,RRM2,SNAP25,TNFSF14 15 (5) 5 PGF,SALL4 Ca2+,miR-34a-5p (and other miRNAs w/seed GGCAGUG) CCNE1,RRM2 PROS1 other 2 0.832 2.18E-03 8.30E-03 Akt,ERK1/2,F5,KDR,PROS1,PTPN11 ABCA3,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,FASN,ITGB3,L1CAM,MMRN1,PLG,RRM2,TNFSF14 13 (6) 5 CK1,forskolin GRN,HOXA10 MERTK Complement,F5,IFNB1 RGS3 enzyme 0.000 2 1.342 2.18E-03 2.02E-02 AKT1,CTNNB1,ERK,ERK1/2,NFkB (complex),RGS3 ACAA1,ADGRG6,ALDH7A1,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,EMX2,HNRNPM,ITGB3,KIFC1,L1CAM,MATR3,PGK1,PLG,PLIN2,SOD3,SUSD2 20 (6) 5 MAP3K8 AKT1,NFkB (complex) FSTL1 other 0.000 2 -1.886 2.20E-03 1.66E-02 Akt,AKT1,ERK,FSTL1,Jnk,NOS3,P38 MAPK,WNT3A ADGRG6,AIMP2,ANK1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,HNRNPM,ITGB3,L1CAM,LRP6,MATR3,PLG,RRM2,SOD3,TNFSF14,TNXB 18 (8) 8 ESR2 RXRA LRP6,Na+,K+ -ATPase,WNT3A cyclophosphamide chemical drug 2 -1.414 2.20E-03 1.64E-02 ABCC4,ACHE,Akt,ATM,cyclophosphamide,ERK1/2,Jnk,MAPK9,NR1I2,PI3K (complex) AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CD209,CLEC10A,CYP39A1,GSTM3,HSD3B2,ITGB3,L1CAM,PLG,PLIN2,RRM2,SLC5A7,SOD3,TNFSF14 18 (10) 9 anandamide,ATF3,CDKN2A ACHE,RAC2 sGC complex 2 -1.291 2.22E-03 1.16E-02 Akt,ERK1/2,NOS3,RB1,sGC AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CALCRL,CELSR1,H2BC21,ITGB3,L1CAM,MAPK4,PLG,RRM2,SOD3,TNFSF14 15 (5) 4 1,1-diethyl-2-hydroxy-2-nitrosohydrazine,Ca2+,carbon monoxide,cinaciguat USP33 peptidase 0.000 2 -0.707 2.24E-03 6.00E-03 DIO2,EPAS1,USP33 ANGPT2,FASN,GLB1,ITGB3,L1CAM,SERINC2,SYCE2,TMPRSS6 8 (3) 2 DIO2,EPAS1 AHNAK other 3 0.000 2.26E-03 4.28E-02 AHNAK,EGFR,ERK,ERK1/2,IRF3,Jnk,JUN,NCL,NFKB1,NFKBIA,NRAS,P38 MAPK,Pkc(s),PLC gamma,PLCG1,PRKCB,PRKCZ,RAF1,Smad,SMAD3,SMAD4,SMAD7 ADGRG6,ANGPT2,ANK1,ANOS1,AOC1,CALCRL,CASP2,CLEC10A,DGAT1,FASN,GNAO1,IFI44,ITGB3,KRT8,LITAF,NCAN,PLG,POLI,PTPRK,RRM2,SLC16A7,TNXB,TULP4,VPS25 24 (22) 18 BIIE 0246,CDK4/6,HNF4A LIF PLC gamma CCND2 hydrogen sulfide chemical - endogenous mammalian 2 -1.225 2.26E-03 3.36E-02 Akt,AKT1,hydrogen sulfide,IRS1,MAPK1,MAPK14,MAPK3,NOS3,PI3K (complex),PRKCE,PTEN,STAT3 ACAA1,AIMP2,ANGPT2,B4GALT1,BIRC2,BIRC3,CALCRL,CD209,CEBPD,CELSR1,CHRNB3,FLNC,HNRNPM,IFI44,ITGB3,L1CAM,LRP6,MATR3,PGK1,PLG,PTPRK,RRM2,SOD3,TNFSF14 24 (12) 11 Ca2+ AKT1,carbon monoxide,HMOX1,Hsp90,IRS1 lead piroxicam chemical drug 2 1.000 2.27E-03 1.41E-02 ALOX5,Ap1,aspirin,CTNNB1,Jnk,piroxicam,PTGS1,PTGS2 ACAA1,ANGPT2,CALCRL,CALM1 (includes others),CD209,CLEC10A,EMX2,FASN,ITGB3,KIFC1,L1CAM,PGK1,PLG,PLIN2,RRM2,SUSD2 16 (8) 7 as-604850 chemical drug 2 Activated 2.138 2.27E-03 1.02E-02 Akt,AKT1,as-604850,ERK1/2,PIK3CG AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,KRT8,L1CAM,MATR3,PLG,RRM2,TNFSF14 14 (5) 4 AKT1,PIK3CG MRAS enzyme 0.000 2 -0.853 2.27E-03 3.06E-02 Akt,AKT1,Ap1,ERK,ERK1/2,MAPK1,MAPK8,MRAS,NFkB (complex),RAF1 ADGRG6,AIMP2,ALDH7A1,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CALM1 (includes others),CEBPD,DGAT1,FASN,FLNC,HNRNPM,IFI44,L1CAM,MATR3,PLG,PTPRK,SLC16A7,SOD3,TNFSF14 22 (10) 9 MFAP5,RASA1,RASGRP1,WNT1 AKT1,ETV1,NFkB (complex) allyl isothiocyanate chemical toxicant 2 -0.832 2.30E-03 8.10E-03 allyl isothiocyanate,BCL2,ERK1/2,IRF3,JINK1/2,MAPK8,Pkc(s) ANGPT2,ANOS1,AOC1,B4GALT1,BIRC2,BIRC3,DGAT1,FASN,IFI44,ITGB3,KRT8,PLG,SNAP25 13 (7) 6 Cofilin,HMOX1,JINK1/2 ammonium chemical - endogenous mammalian 3 -0.277 2.30E-03 1.01E-02 ADM,ammonium,Complement,ERK,Jnk,MAPK8 ADGRG6,ANGPTL3,B4GALT1,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FLNC,ITGB3,LGMN,PGK1,PLG 13 (6) 5 CAPNS1,CCNE1,Complement,DYSF,LRRFIP1,MCTS1,PDLIM1,RGS16,SLC25A4,ZEB2 CAV3,NLRX1,ST13 STK25 kinase -0.000 1 0.000 2.30E-03 3.50E-03 STK25 FASN,PLIN2 2 (1) 1 Ca2+ manassantin B chemical - endogenous non-mammalian 1 1.414 2.30E-03 2.10E-03 manassantin B CEBPD,FASN 2 (1) 1 SCD TAS1R3 G-protein coupled receptor 2 -1.155 2.33E-03 8.10E-03 Akt,EIF4EBP1,ERK1/2,p70 S6k,TAS1R3 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,ITGB3,L1CAM,PLG,RRM2,TNFSF14 12 (5) 4 sucrose SLC3A2 GABARAPL2 other 0.000 3 -1.291 2.33E-03 1.52E-02 Akt,ERBB2,GABARAPL2,PI4K2A AIMP2,ANGPT2,BIRC2,DPY19L3,FASN,ITGB3,L1CAM,LGMN,PGK1,PLG,POLI,PTPRK,RRM2,SERINC2,TNFSF14 15 (4) 3 prednisolone PDGFB,PI4K2A PGR ligand-dependent nuclear receptor 2 Inhibited -2.117 2.34E-03 4.23E-02 CTNNB1,ERK1/2,estrogen receptor,MMP2,NFkB (complex),PGR,SRC (family),STAT1,STAT3,STAT5B ACAA1,ALDH7A1,AOC1,B4GALT1,BIRC2,BIRC3,CASP2,CD209,CEBPD,CYP39A1,EMX2,FASN,FLNC,GSTM3,HSD3B2,IFI44,ITGB3,KIFC1,KRT8,L1CAM,MMRN1,PLG,PLIN2,RRM2,SNAP25,SOD3,SUSD2 27 (10) 10 8-bromo-cAMP,alpha-estradiol,EP300,FGR,forskolin,L-triiodothyronine,lead,MAP3K8,NCOA3,NR5A2,PAK2 CALM1 (includes others),CDK2AP1,cerivastatin,ESR2,GPS2,Hsp90,LIF,NR0B1,onapristone,RAD51C,TAOK2 ACSL1,CCN5,DSCAM,EPAS1,MFAP5,MTSS1,NET1,NQO2,PDLIM1,PIP5K1B,TGFBI,TSC22D3 IRS1,LHB,NFkB (complex) phosphate chemical - endogenous mammalian 2 -1.342 2.35E-03 2.08E-02 ACACA,Akt,ERK,ERK1/2,Jnk,MAPK1,MAPK3,P38 MAPK,PC,phosphate ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,FLNC,IFI44,ITGB3,L1CAM,PLG,PTPRK,RRM2,TNFSF14 20 (10) 9 DIO2,SLC6A3 AKT1,Ca2+,CNN1,PC SLK kinase 0.000 2 -0.905 2.36E-03 7.20E-03 Ap1,Jnk,MAPK14,MAPK8,SLK B4GALT1,BIRC3,CALM1 (includes others),CD209,CEBPD,CLEC10A,DGAT1,FASN,LRP6,PLG,RRM2 11 (5) 4 diacerein chemical drug 2 1.414 2.36E-03 1.51E-02 Akt,diacerein,IKBKB,IL6ST,Jnk,STAT3 AIMP2,ANGPT2,BIRC2,BIRC3,CD209,CEBPD,CGAS,CLEC10A,FASN,ITGB3,KRT8,L1CAM,PGK1,PLG,RRM2,SLC5A7,SOD3,TNFSF14 18 (6) 5 G Protein I complex 2 -1.606 2.37E-03 2.17E-02 Akt,ERK1/2,G Protein I,GNB3,MAPK1,MAPK3,P38 MAPK,PIK3CA,PIK3CG,RGS4,SPHK1 AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,FLNC,GNAO1,IFI44,KRT8,L1CAM,MEGF6,PLG,PTPRK,RRM2,SSPOP,TNFSF14 19 (11) 10 PIK3CA,PIK3CD,PIK3CG,RGS4,SPHK1 U 50488H chemical reagent 2 0.535 2.39E-03 1.51E-02 Akt,ERK1/2,MAPK14,MAPK8,NOS3,U 50488H AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,CEBPD,DGAT1,ITGB3,L1CAM,LRP6,PLG,RRM2,SOD3,TNFSF14 14 (6) 5 OPRK1 triacsin C chemical reagent 3 0.000 2.39E-03 1.17E-02 ACSL1,ACSL4,Akt,arachidonic acid,fatty acid,IRS1,MAPK8,MAPK9,triacsin C AIMP2,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,DGAT1,ITGB3,L1CAM,PLG,PLIN2,RRM2,SOD3,TNFSF14 14 (9) 7 ACSL1 STO-609 chemical - kinase inhibitor 2 0.775 2.39E-03 1.25E-02 ACACA,Akt,AMPK,Creb,ERK1/2,Jnk,NOS3,PRKAA,STO-609 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CD209,CLEC10A,DPY19L3,FASN,ITGB3,L1CAM,PLG,RRM2,SOD3,TNFSF14 15 (9) 8 Cofilin DUSP8 phosphatase 2 1.000 2.40E-03 1.47E-02 DUSP8,ERK,Jnk,MAPK1,MAPK14,MAPK8,MAPK9,P38 MAPK ADGRG6,ANK1,B4GALT1,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FLNC,IFI44,ITGB3,LRP6,PLG,PLIN2,PTPRK,SOD3 16 (8) 7 anisomycin,TMPRSS2-ERG RASA1 transporter -0.000 2 0.229 2.42E-03 2.67E-02 Akt,AKT1,AURKB,ERK,ERK1/2,HRAS,MAPK1,RAS,RASA1,SRC ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,CALCRL,FLNC,HNRNPM,IFI44,ITGB3,L1CAM,MATR3,PGK1,PLG,PTPRK,RRM2,TENM3,TNFSF14 19 (10) 9 phytohemagglutinin DOK1,mir-182,p85 (pik3r) AKT1,MRAS JZL195 chemical reagent 3 -0.894 2.42E-03 2.85E-02 Akt,AKT1,EP300,ERK1/2,FAAH,JZL195,LIPE,MAPK14,P38 MAPK,PI3K (complex),Pkc(s),PNPLA2,PPARA,PRKCE,RAS AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CHRNB3,GSTM3,HNRNPM,KRT8,L1CAM,LRP6,MATR3,PGK1,PLG,PLIN2,RRM2,SERINC2,TNFSF14 20 (15) 13 tributyltin chemical reagent 2 0.500 2.43E-03 1.64E-02 Akt,Jnk,MAPK3,P38 MAPK,PPARG,tributyltin ACAA1,AIMP2,ANK1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FASN,ITGB3,L1CAM,PLIN2,RRM2,TNFSF14 16 (6) 5 ANGPTL4,CASP3,CCN5 ACSL1,IL11,PPARA DKK group 3 -0.218 2.44E-03 2.91E-02 Akt,CTNNB1,DKK,DKK1,Frizzled,FZD9,GSK3B,Jnk,MAPK8,MAPT,Pkc(s),PTEN ACAA1,AIMP2,ANGPT2,ASPG,B4GALT1,BIRC2,CALCRL,CD209,CELSR1,CLEC10A,DGAT1,EMX2,IFI44,KIFC1,KRT8,L1CAM,PLG,PLIN2,RRM2,SUSD2,TNFSF14 21 (12) 10 Frizzled xanthohumol chemical drug 1 1.732 2.44E-03 1.40E-03 xanthohumol BIRC2,BIRC3,FASN 3 (1) 1 NFkB (complex),SCD,Srebp GABARAPL1 other 3 -1.291 2.45E-03 1.56E-02 Akt,ERBB2,GABARAPL1,PI4K2A AIMP2,ANGPT2,BIRC2,DPY19L3,FASN,ITGB3,L1CAM,LGMN,PGK1,PLG,POLI,PTPRK,RRM2,SERINC2,TNFSF14 15 (4) 3 FOXO4 INS,prednisolone OPRK1,PDGFB,PI4K2A dibenzoylmethane chemical toxicant 2 1.604 2.45E-03 1.12E-02 Akt,dibenzoylmethane,ERK1/2,Jnk,P38 MAPK AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,L1CAM,PLG,RRM2,TNFSF14 14 (5) 4 leukotriene B4,prostaglandin E2 Inhibin A complex 3 -0.426 2.46E-03 3.36E-02 Akt,ERK1/2,FSH,IL1,INHA,INHBA,Inhibin A,Jnk,P38 MAPK,RB1,SMAD3 ADAMTS16,AIMP2,ANK1,AOC1,CALCRL,CD209,CELSR1,CLEC10A,Cyp2d22,DGAT1,EMILIN2,FLNC,H2BC21,HSD3B2,ITGB3,KRT8,L1CAM,MAPK4,PTPRK,SNAP25,TNFSF14,TRAF3IP2 22 (11) 10 anandamide chemical - endogenous mammalian 2 Inhibited -2.183 2.48E-03 2.44E-02 AKT1,anandamide,Ap1,CNR1,ERK,ERK1/2,Histone h3,Jnk,MAPK14,NFKB1,P38 MAPK,PTK2 ADGRG6,ANGPT2,ANK1,AOC1,BIRC2,CALM1 (includes others),CEBPD,CLEC10A,GNAO1,HNRNPM,ITGB3,LRP4,LRP6,MATR3,PLG,PLIN2,RRM2 17 (12) 12 6-hydroxydopamine,cyclophosphamide,oleic acid LIF AKT1,ANGPTL4,BCAR1,cannabinoid receptor,CASP3,HSBP1,PPARD NMDA Receptor,NTRK1 marinobufagenin chemical - endogenous mammalian 2 -1.941 2.52E-03 9.30E-03 Akt,Jnk,marinobufagenin,P38 MAPK,p70 S6k,SRC (family) AIMP2,ANK1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,ITGB3,L1CAM,PLG,RRM2,TNFSF14 13 (6) 5 Na+,K+ -ATPase sucrose chemical - endogenous mammalian 2 Inhibited -2.000 2.54E-03 1.52E-02 Akt,Focal adhesion kinase,MAPK1,MAPK8,P38 MAPK,sucrose AIMP2,ANK1,BIRC2,BIRC3,CEBPD,DGAT1,FASN,FLNC,IFI44,KRT8,L1CAM,PLG,PTPRK,RRM2,TKFC,TNFSF14 16 (6) 6 ACSS2,Focal adhesion kinase,GPAM,PIP5K1B,SCD,TAS1R3 DUSP16 phosphatase -0.000 2 0.535 2.54E-03 1.10E-02 DUSP16,Jnk,MAPK1,MAPK14,MAPK8,MAPK9 B4GALT1,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FLNC,IFI44,ITGB3,LRP6,PLG,PLIN2,PTPRK,SOD3 14 (6) 5 deferoxamine TRAF1 other -0.000 2 -0.832 2.56E-03 9.80E-03 ERK1/2,Jnk,MAPK8,Mek,TICAM1,TRAF1 ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CASP2,CD209,CEBPD,CLEC10A,DGAT1,FASN,ITGB3,PLG 13 (6) 5 bryostatin 1,camptothecin,phytohemagglutinin,SPHK1 gambogic acid,indole-3-carbinol,infliximab,lonafarnib,MEOX2,noscapine,RPSA,salinosporamide A,zerumbone IFNB1 Complement component 1 complex 3 0.258 2.56E-03 1.77E-02 ADM,C1q,C4A/C4B,Complement,Complement component 1,Creb,ERK,ERK1/2,Jnk,MAPK14,MAPK8,P38 MAPK ADGRG6,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,CD209,CLEC10A,DGAT1,DPY19L3,FASN,LRP6,PGK1,PLG,RRM2 15 (12) 8 IgG Complement ADRA1 group 2 Inhibited -2.000 2.57E-03 1.57E-02 ADRA1,Akt,CNR1,ERK,ERK1/2,MAPK8,p70 S6k ADGRG6,AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,DGAT1,FASN,ITGB3,L1CAM,LRP4,PLG,RRM2,TNFSF14 16 (7) 6 RRM2 enzyme -3.398 2 0.000 2.57E-03 3.07E-02 Akt,BCL2,ERK1/2,FOXM1,HIF1A,Jnk,NFkB (complex),P38 MAPK,RRM2,SNAI1 AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,GLB1,ITGB3,KRT8,PGK1,PLG,SLC16A4,SNAP25,SOD3,TMPRSS6,TNFSF14 22 (10) 9 8-bromo-cAMP,ATF3,ATM/ATR,ATR,camptothecin,CDK4/6,E2F2,forskolin,NF-Y,phorbol 12,13-dibutyrate BI 836845,CHIR-124,fludarabine phosphate,Irgm1,KU-55933,miR-99a-3p (and other miRNAs w/seed AAGCUCG),MIR4500,MIR5095,MK-8776,TBRG4 dATP,NFkB (complex) riluzole chemical drug 2 1.604 2.57E-03 1.49E-02 Akt,CYP1A2,ERK,HSF1,riluzole ADGRG6,AIMP2,BIRC2,CACHD1,CEBPD,CELSR1,FASN,GSTM3,ITGB3,L1CAM,PGK1,PLG,RRM2,TNFSF14 14 (5) 4 Hsp90 NMDA Receptor PLD1 enzyme 2 -1.460 2.58E-03 3.93E-02 Akt,AKT1,ERK,ERK1/2,IGF1,MAPK14,MAPK8,NFkB (complex),PDPK1,PLD1,SPHK1,SRC,SRC (family) ADGRG6,AIMP2,ALDH7A1,ANGPT2,AOC1,ATL2,B4GALT1,BIRC2,BIRC3,DGAT1,HNRNPM,ITGB3,L1CAM,LRP6,MATR3,PGK1,PLG,PLIN2,RAB11A,RRM2,SOD3,THSD4,TNFSF14 23 (13) 12 Ca2+,Cofilin,DSCAM,HTR1B,LIF,MAP2K2,miltefosine,PEA15,phosphatidylinositol 3,4-diphosphate,phytohemagglutinin,RAC2,VEGFB,WNT3A caffeic acid phenethyl ester,camptothecin,quercetin AKT1,ATF2,RPS6KB1,SPHK1 SOS2 selenodiglutathione chemical - endogenous mammalian 2 -1.941 2.59E-03 8.70E-03 AKT1,ERK1/2,MAPK8,P38 MAPK,selenodiglutathione ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,DGAT1,FASN,HNRNPM,ITGB3,MATR3,PLG 13 (5) 4 AKT1,FASLG MAP2K2 kinase 2 -1.698 2.61E-03 1.65E-02 AKT1,Creb,ERK,ERK1/2,MAP2K2,MAPK1,MAPK3 ADGRG6,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,DPY19L3,FASN,FLNC,HNRNPM,IFI44,ITGB3,MATR3,PLG,PTPRK,RRM2 17 (7) 6 AKT1,HSBP1,IRS1,PDGFRA,PLD1 CDKN2A,TREM2 perifosine chemical drug 3 -0.438 2.62E-03 4.93E-02 Akt,AKT1,CASP3,CASP8,CDK1,CDK2,CEBPA,COP1,DICER1,E2F3,EIF4E,ELAVL1,ERK,ERK1/2,FADD,HMOX1,IL10,IL1B,IRF3,Jnk,JUN,MAPK1,Mek,MITF,MYB,MYOD1,NGEF,perifosine,PPARGC1A,RICTOR,RXRA,SIRT1,SMARCA4,SOX2,SPARC,TCF7L2,TGFB1,TNF,TNFSF11,TSC1 ADGRG6,AGA,AIMP2,AKNA,ANGPT2,ANGPTL3,ANOS1,AOC1,BIRC2,C1QL1,CACHD1,CALML3,CASP2,CD209,CLEC10A,CR1,EMILIN2,ETNK1,FLNC,FRRS1,HCRTR2,HNRNPM,IFI44,KMT5A,L1CAM,Lgals6,LRP4,LRP5,MATR3,MMRN1,NLGN2,PIF1,POLI,PTPRK,RRM2,RSL24D1,SCARF1,SNAP25,SVEP1,SYT12,TNFSF14,TNR,TRAF3IP2,TRIM2,TRIM36,TRIM56,TULP4 47 (40) 36 CASP3,ceramide AKT1,PCGF2 TGFBI other 0.000 2 -1.387 2.66E-03 1.20E-02 Akt,ERK,Jnk,PTK2,SRC,TGFBI ADGRG6,AIMP2,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,L1CAM,PGK1,PLG,RRM2,TNFSF14 13 (6) 5 CISH,PGR,SOX7,TMPRSS2-ERG FRZB other 0.000 3 1.279 2.68E-03 4.02E-02 Akt,CTNNB1,ERK1/2,Frizzled,FRZB,FZD9,Gsk3,LEF1,MAPK8,Pkc(s),Wnt,WNT3A,WNT4,WNT5A ACAA1,AIMP2,ANGPT2,AOC1,B4GALT1,CSRNP3,DGAT1,EMX2,FAM234B,FASN,GNAO1,IFI44,KIFC1,KRT8,LRP5,PGK1,PLG,PLIN2,RRM2,SUSD2,TNFSF14,TNXB 22 (14) 11 BHLHE40,POU5F1 Frizzled EPAS1 transcription regulator 0.000 1 -0.816 2.70E-03 8.40E-03 EPAS1 ANGPT2,FASN,GLB1,ITGB3,L1CAM,TMPRSS6 6 (1) 1 deferoxamine,Hsp90,L-triiodothyronine,NFkB (complex),NOX1,NOX4,PGR,TFAP2B,USP33,WNT3A DAB2IP,doxycycline,P4HTM,TINCR,TRPM2 ANGPTL4,BHLHE40,CCN5,ceramide,ICOS,ITPR1,PDGFB,PGF,POU5F1,RGS4,SLC2A1,SOD1,SPHK1,TERT FASLG phenformin chemical drug 2 -1.897 2.73E-03 1.37E-02 EIF2AK3,ERN1,phenformin,PRKAA1,PRKAA2 BIRC2,BIRC3,CEBPD,DGAT1,H2BC21,HSD3B2,IFI44,LITAF,PLIN2,PNLIP 10 (5) 4 ERN1,PRKAA1,SLC2A1 dATP,RPS6KB1 GPI enzyme 0.000 2 -1.387 2.73E-03 1.15E-02 Akt,CDK2,GPI,MAPK8,MAPK9 AIMP2,B4GALT1,BIRC2,BIRC3,DGAT1,FASN,L1CAM,PLG,PLIN2,RRM2,SNAP25,SOD3,TNFSF14 13 (5) 4 Ck2 alpha,POU5F1 ZEB2 caspase RXRA ligand-dependent nuclear receptor 0.000 2 1.177 2.74E-03 4.45E-02 Akt,Ap1,CEBPB,CTNNB1,estrogen receptor,NR1H4,NR1I3,PPARA,RXRA,SOX9,VDR AIMP2,ANGPT2,ANGPTL3,AOC1,BIRC2,CALM1 (includes others),CEBPD,CUBN,CYP39A1,DUT,EMX2,FASN,FLNC,GSTM3,KIFC1,KRT8,LGMN,LRP6,PGK1,PLG,PPP1CA,RRM2,SERINC2,SOD3,SUSD2,TNFSF14 26 (11) 11 indomethacin,JINK1/2,KLRC4-KLRK1/KLRK1,LG100268,oleic acid,phytohemagglutinin,PTN,RBP1 acyclic retinoid,caffeic acid phenethyl ester CCR9,EHHADH,HSD17B4,IGFBP6,NR5A2,NTRK1,PC,POU5F1,PPARA CXCL10,FSTL1,HMOX1,NPY,PDGFB,PMP22 TNFRSF11A transmembrane receptor 2 -1.091 2.74E-03 2.97E-02 Akt,Ap1,ERK,Jnk,MAPK8,NFkB (complex),NFKB1,NFKBIA,P38 MAPK,PRKCB,TNFRSF11A ADGRG6,AIMP2,ALDH7A1,ANK1,B4GALT1,CALM1 (includes others),CD209,CEBPD,CLEC10A,DGAT1,FASN,GNAO1,ITGB3,KRT8,L1CAM,LITAF,NCAN,PLG,RRM2,SOD3,TNFSF14 21 (11) 10 IL20,WNT5A (1S,2R)-NCL-1,14,15-epoxyeicosatrienoic acid,NCD-38,PPP3R1,quercetin,zoledronic acid Ca2+,MME,NFkB (complex),POU5F1 TFAP2B irinotecan chemical drug 2 -0.426 2.75E-03 3.38E-02 ACHE,Akt,AMPK,CYP1A2,EGFR,ERK,irinotecan,NFkB (complex),P38 MAPK,STAT1,TOP1 ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,B4GALT1,BIRC2,BIRC3,CACHD1,CASP2,CEBPD,FASN,GLB1,GSTM3,ITGB3,L1CAM,PLG,RRM2,SLC5A7,SOD3,TNFSF14,TNXB 22 (11) 10 CASP3,CXCL10,IFNB1,NFkB (complex),prostaglandin E2 ACHE,PHLPP1,SOCS3 AKTIP other -0.000 2 Inhibited -2.111 2.76E-03 7.90E-03 Akt,AKT1,AKTIP AIMP2,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,L1CAM,MATR3,PLG,RRM2,TNFSF14 11 (3) 2 AKT1 LDL-cholesterol complex 2 -1.807 2.78E-03 1.57E-02 CTNNB1,ERK1/2,LDL-cholesterol,P38 MAPK ACAA1,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CEBPD,EMX2,FASN,ITGB3,KIFC1,L1CAM,PGK1,PLIN2,SUSD2 15 (4) 3 CX3CL1 FFAR4,SCP2 naproxen chemical drug 2 0.894 2.81E-03 2.66E-02 Akt,aspirin,CHUK,CTNNB1,naproxen,NFkB (complex),PTGS1,PTGS2 ACAA1,AIMP2,ALDH7A1,ANGPT2,B4GALT1,BIRC2,BIRC3,CALCRL,CEBPD,EMX2,FASN,ITGB3,KIFC1,PGK1,PLG,PLIN2,RRM2,SOD3,SUSD2,TNFSF14 20 (8) 7 leukotriene B4 NFkB (complex),prostaglandin E2 PDGFC growth factor 2 -1.807 2.82E-03 1.54E-02 Akt,AKT1,ERK1/2,IGF1R,KDR,PDGFC AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,HSD3B2,ITGB3,L1CAM,MATR3,PLG,RRM2,TNFSF14 15 (6) 5 8-bromo-cAMP,carbon tetrachloride,S100A9 SALL4,SETD2 AKT1,PDGFRA CASP3 Inhibin complex 3 -0.426 2.82E-03 3.84E-02 Akt,ERK1/2,FSH,IL1,INHA,INHBA,Inhibin,Jnk,P38 MAPK,RB1,SMAD3 ADAMTS16,AIMP2,ANK1,AOC1,CALCRL,CD209,CELSR1,CLEC10A,Cyp2d22,DGAT1,EMILIN2,FLNC,H2BC21,HSD3B2,ITGB3,KRT8,L1CAM,MAPK4,PTPRK,SNAP25,TNFSF14,TRAF3IP2 22 (11) 10 LHB HOXB5 transcription regulator 1 0.000 2.86E-03 4.40E-03 HOXB5 ANGPT2,ITGB3 2 (1) 1 MIR17HG dehydroxymethylepoxyquinomicin chemical reagent 1 1.414 2.86E-03 3.60E-03 dehydroxymethylepoxyquinomicin BIRC2,BIRC3 2 (1) 1 NFkB (complex) birabresib chemical drug 2 Inhibited -2.449 2.86E-03 6.80E-03 birabresib,EIF2AK3 BIRC2,BIRC3,H2BC21,IFI44,NANOS1,PNLIP 6 (2) 2 MFNG,NTRK1,USP18 PRKD2 kinase 2 -0.218 2.87E-03 3.27E-02 Creb,CREB1,IFNAR1,Jnk,MAPK3,MMP9,NFkB (complex),P38 MAPK,PLAU,PRKD2,RTKN,SPHK2 ALDH7A1,ANK1,B4GALT1,BIRC2,BIRC3,CASP2,CD209,CEBPD,CGAS,CLEC10A,DPY19L3,FASN,IFI44,ITGB3,L1CAM,LITAF,MGAT4C,PLG,RRM2,SERINC2,SOD3 21 (12) 11 CASR,GAST kb-NB 142-70 NFkB (complex) Cofilin MDM2 transcription regulator 1 0.000 2.88E-03 4.10E-03 MDM2 CASP2,H2BC21,TSG101,WRN 4 (1) 1 6-hydroxydopamine,8-bromo-cAMP,ADAM10,AKT1,anisomycin,ATM/ATR,ATR,benzo(a)pyrene,BRD7,camptothecin,Ck2 alpha,COPS6,CSNK1D,deferoxamine,EP300,lactacystin,MCTS1,mitomycin C,NFkB (complex),phorbol 12,13-dibutyrate,PLAC8,PTTG1,RPS6KB1,Secretase gamma,USP2,zinostatin ALRN-6924,diosgenin,etoposide,Focal adhesion kinase,forskolin,Pak,PAK2,PPP5C,PRNP,PTPA,roscovitine,SEMA3B,SENP2,TSPYL2 IGFBP6 Beta Arrestin,caspase,ESR2,IRS1,TERT (E)-2,3',4,5'-tetramethoxystilbene chemical drug 2 1.807 2.88E-03 1.37E-02 (E)-2,3',4,5'-tetramethoxystilbene,Akt,CYP1A1,CYP1A2,CYP1B1,ERK1/2,P38 MAPK,SRC AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CACHD1,CEBPD,GSTM3,ITGB3,L1CAM,PGK1,PLG,RRM2,TNFSF14 15 (8) 7 RAPGEF1 other 0.000 2 1.291 2.88E-03 2.08E-02 ERK,ERK1/2,Jnk,MAPK8,Mek,NFKBIA,RAPGEF1 ADGRG6,ANGPT2,AOC1,B4GALT1,CASP2,CD209,CEBPD,CLEC10A,DGAT1,FASN,KRT8,LITAF,NCAN,PLG,SOD3 15 (7) 6 8-bromo-cAMP,CASR,CRKL,forskolin,RELN RAP1A PF-573228 chemical drug 2 -0.302 2.89E-03 1.08E-02 Akt,Focal adhesion kinase,MMP2,NEDD9,PF-573228,PTK2 AIMP2,BIRC2,BIRC3,KRT8,L1CAM,PGK1,PLG,PLIN2,RRM2,TNFSF14,TPPP3 11 (6) 5 TJP1 CDH2,Focal adhesion kinase FGF7 growth factor 2 -1.460 2.90E-03 3.71E-02 Akt,CYP19A1,ERK,ERK1/2,FGF7,FGFR2,MAPK1,MAPK8,NFKB1,P38 MAPK,RAF1,SRC (family) ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,ASPG,BIRC2,BIRC3,CD209,CEBPD,CUBN,FASN,FLNC,GNAO1,IFI44,ITGB3,L1CAM,PLG,PLIN2,RRM2,SLC16A7,TENM3,TNFSF14 23 (12) 12 doxycycline,FGF9,nifedipine,PDGF-AA,PDGFB IRX1 Ca2+,fatty acid,HAS2,LPCAT1,Nrg1,PLC gamma,PTAFR,SCD CASP3,CDKN2A,INS CCR7 G-protein coupled receptor 2 -1.789 2.91E-03 3.33E-02 Akt,AKT1,CCR7,ERK1/2,FOXO1,ITGB1,Jnk,P38 MAPK,PRKAA1 AIMP2,ANGPT2,ANK1,AOC1,CASP2,CD209,CLEC10A,FASN,H2BC21,HNRNPM,HSD3B2,IFI44,L1CAM,LITAF,LRP6,MATR3,PLG,RRM2,TNFSF14,TNXB 20 (9) 8 BHLHE40,CDKN2A,CLEC7A,deferoxamine,MAP3K7,NFkB (complex),PD173074,phytohemagglutinin,prostaglandin E2,TREM2 CAMP AKT1,GNAI3,ITGA4,levothyroxine,PRKAA1 Cofilin Centralspindlin complex 3 -1.807 2.91E-03 1.83E-02 Centralspindlin,ECT2,JUN,MAPK14,MAPK8,PRKCZ,RACGAP1,RB1,RHOB ANGPT2,B4GALT1,BIRC2,BIRC3,CALCRL,CASP2,CELSR1,DGAT1,FASN,H2BC21,ITGB3,LRP6,MAPK4,POLI,RRM2 15 (9) 6 VTCN1 other 2 1.732 2.93E-03 1.01E-02 Akt,ERK,Jnk,VTCN1 ADGRG6,AIMP2,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,L1CAM,PLG,RRM2,TNFSF14 12 (4) 3 PD173074 CCNE1 N,N-dimethylsphingosine chemical reagent 2 0.853 2.95E-03 3.69E-02 Akt,Ap1,Creb,ERK1/2,Jnk,LDL,MAPK1,MAPK3,N,N-dimethylsphingosine,NFkB (complex),P38 MAPK AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,CALM1 (includes others),CD209,CEBPD,CLEC10A,DPY19L3,FASN,FLNC,IFI44,ITGB3,L1CAM,PLIN2,PTPRK,RRM2,SOD3,TNFSF14 22 (11) 10 CASP3,SPHK1 Ca2+,NFkB (complex) bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate chemical reagent 2 Inhibited -2.111 2.98E-03 9.70E-03 Akt,AKT1,bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate AIMP2,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,L1CAM,MATR3,PLG,RRM2,TNFSF14 11 (3) 2 AKT1 CASP3 CD93 other 2 -0.535 2.98E-03 2.04E-02 Akt,CD93,CTNNB1,PTK2 ACAA1,AIMP2,BIRC2,BIRC3,EMX2,FASN,KIFC1,L1CAM,PGK1,PLG,PLIN2,RRM2,SUSD2,TNFSF14 14 (4) 3 ciprofloxacin,ESR2 alpha-pinene chemical drug 3 -0.853 3.00E-03 3.09E-02 alpha-pinene,BCL2,CHUK,ERK,IKBKB,MAPK8,MAPK9,MMP2,MMP9,MPO,MTOR,NFkB (family),NFKB2,NFKBIA,PRKAA2,PTGS2,REL,SERPINE1 ADGRG6,AGA,ANGPT2,B4GALT1,BIRC2,BIRC3,C1QTNF3,CEBPD,DGAT1,DUT,FASN,IFI44,ITGB3,KRT8,L1CAM,LITAF,NCAN,PLG,PLIN2,RRM2,SNAP25,SOD3 22 (18) 16 SFRP2 transmembrane receptor 2 -0.577 3.01E-03 1.63E-02 CTNNB1,Jnk,SFRP2 ACAA1,BIRC3,CD209,CLEC10A,EMX2,FASN,KIFC1,L1CAM,PGK1,PLG,PLIN2,SUSD2 12 (3) 2 L-triiodothyronine,levothyroxine,WNT3A caspase,PDGFRA,WNT1 KSR1 kinase 0.000 2 -1.342 3.05E-03 3.51E-02 Akt,ERK,ERK1/2,KSR1,MAPK1,MAPK3,NFKB1,NFKBIA,RAF1,RAS ADGRG6,AIMP2,ANGPT2,AOC1,B4GALT1,CD209,CEBPD,FLNC,GNAO1,IFI44,KRT8,L1CAM,LITAF,NCAN,PLG,PTPRK,RRM2,SLC16A7,SOD3,TNFSF14 20 (10) 9 ceramide CASP3 CDKN2A ipatasertib chemical drug 2 Activated 2.111 3.07E-03 9.80E-03 Akt,AKT1,ipatasertib AIMP2,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,L1CAM,MATR3,PLG,RRM2,TNFSF14 11 (3) 2 AKT1,TREM2 FPR group 3 -0.229 3.10E-03 2.82E-02 Akt,EGFR,ERK,ERK1/2,Focal adhesion kinase,FPR,FPR1,FPR2,Jnk,MAP3K7,MAPK1,MAPK3 ADGRG6,AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,CD209,CEBPD,CLEC10A,FASN,FLNC,IFI44,KRT8,L1CAM,PLG,PTPRK,RRM2,TNFSF14,TNXB 19 (12) 9 PTAFR G-protein coupled receptor 2 -0.728 3.12E-03 2.23E-02 Akt,ERK1/2,Focal adhesion kinase,MAPK1,MAPK3,P38 MAPK,PTAFR,PTK2 AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,FLNC,IFI44,ITGB3,KRT8,L1CAM,PLG,PTPRK,RRM2,TNFSF14 17 (8) 7 carbon tetrachloride,FGF7,L-triiodothyronine,phospholipid,RGS4 phorbol 12,13-dibutyrate CDH2,Focal adhesion kinase,NFkB (complex) CCL3L3 LCP2 other -0.000 2 -0.408 3.13E-03 4.76E-02 Akt,AMPK,Ap1,ERK,ERK1/2,Jnk,LCP2,MAPK1,MAPK8,NFkB (complex),NFKB1,P38 MAPK ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,CALM1 (includes others),CD209,CEBPD,CLEC10A,DGAT1,FASN,FLNC,GNAO1,IFI44,ITGB3,L1CAM,PLG,PTPRK,RRM2,SOD3,TNFSF14 24 (12) 11 BHLHE40,Fc gamma receptor,FCGR1A,FGR,ITGA4,KLRC4-KLRK1/KLRK1,LAT2,SALL4 FOXO4 Ca2+,NFkB (complex),PIK3R2,PLC gamma MRX-2843 chemical drug 3 1.279 3.13E-03 4.15E-02 Akt,CHEK1,ERK1/2,FLT3,GRB2,MAPK8,MAPT,MERTK,MRX-2843,P38 MAPK,PI3K (complex),PTPN11,SRC (family),STAT,STAT3,STAT5A,TLR3 ABCA3,AIMP2,ANGPT2,ANK1,AOC1,ASPG,B4GALT1,BIRC2,BIRC3,CASP2,CD209,CEBPD,DGAT1,EMX2,HSD3B2,ITGB3,L1CAM,PGK1,PLG,PPP1CA,RRM2,TNFSF14 22 (17) 14 MERTK CHI3L1 enzyme 2 -1.886 3.13E-03 2.94E-02 Akt,AMPK,CHI3L1,CTNNB1,ERK1/2,P38 MAPK,PRKAA,PTK2 ACAA1,AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CEBPD,EMX2,FASN,ITGB3,KIFC1,PGK1,PLG,PLIN2,RRM2,SUSD2,TNFSF14 18 (8) 7 mir-182 Ca2+ LOC102724788/PRODH enzyme 0.000 2 -0.471 3.13E-03 3.18E-02 Akt,CTNNB1,EGFR,ERK,GSK3B,LOC102724788/PRODH,Mek ACAA1,ADGRG6,AIMP2,BIRC2,BIRC3,CASP2,CEBPD,EMX2,FASN,ITGB3,KIFC1,PGK1,PLG,PLIN2,RRM2,SUSD2,TNFSF14,TNXB 18 (7) 6 CDKN2A,HNF4A camptothecin,S100A9 prostaglandin E2 phosphatidylinositol chemical - endogenous mammalian 2 -1.147 3.13E-03 3.00E-02 Akt,AKT1,ALOX5,ERK1/2,Jnk,MAPK1,MAPK3,P38 MAPK,phosphatidylinositol,PRKCE,PRKCZ,SERPINE1 AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,CASP2,CD209,CHRNB3,CLEC10A,FASN,FLNC,HNRNPM,IFI44,ITGB3,L1CAM,MATR3,PTPRK,RRM2,TNFSF14 19 (12) 11 Pi3k class I,PIK3CA AKT1,Ca2+,Dynamin Secretase gamma MT-21 chemical drug 2 -0.333 3.14E-03 6.30E-03 Jnk,MAPK8,MAPK9,MT-21 B4GALT1,BIRC3,CD209,CLEC10A,DGAT1,FASN,PLG,PLIN2,SOD3 9 (4) 3 CASP3 mefunidone chemical reagent 2 1.387 3.15E-03 1.16E-02 ERK1/2,Jnk,mefunidone,P38 MAPK,SMAD3 ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FASN,ITGB3,PLG,PTPRK 13 (5) 4 NPHS1 NOX4,TJP1 IL31 other 2 -1.460 3.20E-03 4.28E-02 Akt,ERK1/2,IL31,Jnk,MAPK3,MAPK8,MAPK9,P38 MAPK,PI3K (complex),PTPN11,STAT1,STAT3,STAT5B ABCA3,AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,CYP39A1,DGAT1,HSD3B2,ITGB3,L1CAM,MMRN1,PGK1,PLG,PLIN2,RRM2,SOD3,TNFSF14 23 (13) 12 Ca2+,CAMP,DEFB103A/DEFB103B OSMR CISH,SAA,SOCS3 prazosin chemical drug 2 -1.213 3.21E-03 1.97E-02 CDK2,DIO2,ERK1/2,Jnk,MAPK1,MAPK14,MAPK8,P38 MAPK,prazosin ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CLEC10A,DGAT1,FASN,FLNC,IFI44,LRP6,PLG,PTPRK,SERINC2,SNAP25,SYCE2 17 (9) 8 CASP3 DIO2,Na+,K+ -ATPase,Sik1 MAP3K10 kinase 2 -0.894 3.22E-03 2.93E-02 ERK,Jnk,JUN,MAP2K4,MAP3K10,MAPK1,MAPK14,MAPK8,MAPK9,NDP,P38 MAPK,TCF3 ADGRG6,ANGPT2,ANK1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FLNC,IFI44,ITGB3,LRP6,PGK1,PLG,PLIN2,POLI,PTPRK,SOD3 20 (12) 11 anisomycin,caspase MAP3K11 MAP2K4/7 group 2 -1.155 3.23E-03 1.03E-02 JINK1/2,Jnk,MAP2K4,MAP2K4/7,MAPK7,MAPK8,MAPK9,P38 MAPK ANK1,B4GALT1,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FASN,ITGB3,PLG,PLIN2,SOD3 12 (8) 7 MAP3K11,MAP3K20,MAP3K4,MAP3K7 JINK1/2,MAPK7 GMP chemical - endogenous mammalian 3 -0.816 3.23E-03 4.91E-02 ADORA2A,Akt,EGFR,EP300,ERK,ERK1/2,Focal adhesion kinase,GMP,IKK (complex),Jnk,NADPH oxidase,NFkB (complex),NT5E,P38 MAPK,SP1 ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,ITGB3,KRT8,L1CAM,PGK1,PLG,PPP1CA,RRM2,SNAP25,SOD3,TNFSF14,TNXB 24 (15) 12 CCR9 G-protein coupled receptor 3 -1.043 3.23E-03 4.33E-02 Akt,CCR9,EGFR,EP300,ERK,ERK1/2,IKK (complex),Jnk,NADPH oxidase,NFkB (complex),P38 MAPK,SP1 ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,ITGB3,L1CAM,PGK1,PLG,RRM2,SNAP25,SOD3,TNFSF14,TNXB,TPPP3 23 (12) 11 CDKN2A,RXRA captopril Ca2+ Nrg1 growth factor 2 -1.789 3.28E-03 3.20E-02 Akt,AKT1,ERBB2,ERBB3,ERBB4,ERK,ERK1/2,FOXO1,Nrg1 ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CASP2,DPY19L3,FASN,HNRNPM,ITGB3,L1CAM,MATR3,PGK1,PLG,POLI,PTPRK,RRM2,TNFSF14,TNXB 20 (9) 8 FGF7,tunicamycin AKT1,NMDA Receptor,RPS6KB1 MEN1 transcription regulator 0.000 2 Activated 2.065 3.31E-03 2.90E-02 Akt,AKT1,CTNNB1,ERK1/2,Focal adhesion kinase,JUN,MEN1 ACAA1,AIMP2,ANGPT2,AOC1,BIRC3,CEBPD,EMX2,HNRNPM,ITGB3,KIFC1,KRT8,MATR3,PGK1,PLG,PLIN2,POLI,RRM2,SUSD2,TNFSF14 19 (7) 6 caspase AKT1,Focal adhesion kinase,p85 (pik3r),PTN ajoene chemical - endogenous non-mammalian 2 -1.213 3.31E-03 2.21E-02 ajoene,Akt,MAPK1,MAPK3,MAPK8,MAPK9,P38 MAPK,PRKCD AIMP2,ANK1,B4GALT1,BIRC2,BIRC3,CEBPD,DGAT1,FLNC,IFI44,ITGB3,L1CAM,PLG,PLIN2,PTPRK,RRM2,SOD3,TNFSF14 17 (8) 7 CASP3 CDH17 transporter 2 -0.577 3.36E-03 1.22E-02 CDH17,ERK,ERK1/2,Focal adhesion kinase,ITGB1,Jnk,PTK2 ADGRG6,ANGPT2,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,KRT8,LRP6,PLG,TNXB 12 (7) 6 PPP3R1 Focal adhesion kinase,IgG PIK3R2 kinase 2 -0.728 3.38E-03 2.64E-02 Akt,EIF4E,ERK,IRS2,MKNK1,NFKBIA,PIK3R2 ADGRG6,AIMP2,BIRC3,CEBPD,FASN,GNAO1,ITGB3,KRT8,L1CAM,LITAF,NCAN,NLGN2,PLG,RRM2,SNAP25,SOD3,TNFSF14 17 (7) 6 LCP2 CXCL10,RPS6KB1 FPR1 G-protein coupled receptor 2 0.000 3.38E-03 2.25E-02 Akt,EGFR,ERK1/2,Focal adhesion kinase,FPR1,Jnk,MAPK1,MAPK3 AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CLEC10A,FASN,FLNC,IFI44,KRT8,L1CAM,PLG,PTPRK,RRM2,TNFSF14,TNXB 18 (8) 7 BHLHE40,cytochalasin B,Pam3-Cys Focal adhesion kinase,G protein FRAX-597 chemical drug 2 1.387 3.40E-03 1.44E-02 Akt,ERK,ERK1/2,FRAX-597,PAK2 ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,ITGB3,L1CAM,PLG,RRM2,TNFSF14,WRN 13 (5) 4 PAK2,PAK3 ellagic acid chemical - endogenous non-mammalian 2 1.800 3.43E-03 4.89E-02 Akt,collagenase,CXCL8,ellagic acid,HIF1A,IL6,MMP2,NR1I3,P38 MAPK,PTGS2,Vegf AIMP2,ANGPT2,ANK1,BIRC2,BIRC3,CALCRL,CALM1 (includes others),CD209,CEBPD,CELSR1,CLEC10A,CR1,CYP39A1,FASN,FGL1,ITGB3,KRT8,LRP6,PGK1,PLG,REG1A,RRM2,SLC16A4,TMPRSS6,TNFSF14 25 (11) 10 fatty acid,HMOX1 NFkB (complex) OIP5-AS1 other 2 0.535 3.44E-03 2.07E-02 Akt,CTNNB1,GSK3B,OIP5-AS1 ACAA1,AIMP2,BIRC2,BIRC3,EMX2,FASN,KIFC1,L1CAM,PGK1,PLG,PLIN2,RRM2,SUSD2,TNFSF14 14 (4) 3 mir-154 CKS1B kinase 2 0.832 3.45E-03 1.83E-02 CDK2,CDKN1A,CDKN1B,CKS1B,FOXM1,NFKBIA BIRC2,BIRC3,CEBPD,CLPB,GLB1,ITGB3,KRT8,LITAF,NCAN,PGK1,RRM2,SNAP25,SOD3 13 (6) 5 ESR2 benzo(a)pyrene XAV939 chemical reagent 2 1.387 3.45E-03 1.50E-02 CTNNB1,ERK1/2,XAV939 ACAA1,ANGPT2,AOC1,BIRC2,BIRC3,EMX2,FASN,ITGB3,KIFC1,L1CAM,PGK1,PLIN2,SUSD2 13 (3) 2 IFNB1 LPIN1 phosphatase 2 0.000 3.45E-03 2.69E-02 ERK1/2,Jnk,JUN,LPIN1,P38 MAPK,Pkc(s),PPARG,PRKCE,SREBF1 ACAA1,ANGPT2,ANK1,AOC1,BIRC3,CD209,CEBPD,CHRNB3,CLEC10A,DGAT1,DPY19L3,FASN,GLB1,ITGB3,KRT8,PLG,PLIN2,POLI 18 (9) 9 4beta-hydroxycholesterol,CREB3L3,GW3965,NF-Y,NPY,tolylfluanid Ca2+,miR-217-5p (and other miRNAs w/seed ACUGCAU),oleic acid,tunicamycin PPARA RETN bremelanotide biologic drug 3 -0.728 3.45E-03 2.94E-02 Akt,bremelanotide,Creb,ERK,ERK1/2,HMOX1,MAPK1,MAPK3,MC1R,MC3R,MC4R ADGRG6,AIMP2,ANGPT2,ANGPTL3,AOC1,B4GALT1,BIRC2,BIRC3,DPY19L3,FASN,FLNC,IFI44,L1CAM,PLG,PTPRK,RRM2,TNFSF14 17 (11) 8 RNF41 enzyme 0.000 2 1.091 3.47E-03 3.80E-02 Akt,Ap1,EGFR,ERBB3,ERK,ERK1/2,IRF3,MYD88,NFkB (complex),RNF41 ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANOS1,AOC1,B4GALT1,BIRC2,BIRC3,CALM1 (includes others),CEBPD,CLEC10A,FASN,IFI44,ITGB3,L1CAM,PLG,RRM2,SOD3,TNFSF14,TNXB 21 (10) 9 nelfinavir IFNB1 NFkB (complex) KU-55933 chemical drug 1 1.414 3.48E-03 5.90E-03 KU-55933 GLB1,RRM2 2 (1) 1 CDH5 NFkB (complex),RRM2 amodiaquine chemical drug 1 0.000 3.48E-03 5.40E-03 amodiaquine DGAT1,FASN 2 (1) 1 SLC6A3 PLC gamma group 2 -0.853 3.49E-03 4.71E-02 ERK,ERK1/2,IRF3,Jnk,NFkB (complex),NFKB1,NFKBIA,NRAS,P38 MAPK,Pkc(s),PLC gamma,PRKCB,RAF1 ADGRG6,ALDH7A1,ANGPT2,ANK1,ANOS1,AOC1,B4GALT1,CALCRL,CLEC10A,FASN,GNAO1,IFI44,ITGB3,KRT8,LITAF,NCAN,PLG,RRM2,SLC16A7,SOD3,TULP4,VPS25 22 (13) 12 AHNAK,CD63,CNTF,FGF4,FGF7,ICOS,IgG,KIT,LCP2,NTN1,NTRK1,PDGFRA,phytohemagglutinin,PIK3CG,PTN,SH3BP2,TPOR dimer,VAV1 dovitinib,LAT2 Ca2+ NFkB (complex) EIF3 complex 3 -1.213 3.49E-03 2.63E-02 Akt,CTNNB1,EIF3,EIF3A,EIF3E,EIF3F,EIF3I,PRKAA1 ACAA1,AIMP2,BIRC2,BIRC3,EMX2,FASN,H2BC21,HSD3B2,IFI44,KIFC1,LITAF,PGK1,PLG,PLIN2,SCARF1,SUSD2,TNFSF14 17 (8) 4 ouabain chemical drug 2 -0.816 3.49E-03 4.95E-02 Ap1,EGFR,EIF2AK4,ERK,ERK1/2,HRAS,Jnk,MAPK1,MAPK3,MAPK8,NFkB (complex),ouabain,P38 MAPK,SRC,SRC (family),STAT1 ADGRG6,ALDH7A1,ANK1,AOC1,B4GALT1,CALCRL,CALM1 (includes others),CASP2,CD209,CEBPD,CHAC1,CLEC10A,DGAT1,FASN,FLNC,IFI44,ITGB3,PGK1,PLG,PTPRK,RRM2,SOD3,TENM3,TNXB 24 (16) 15 Ca2+,NADH,NFkB (complex) Na+,K+ -ATPase,NPHS1 iodine chemical - endogenous mammalian 2 -1.508 3.50E-03 1.00E-02 ERK1/2,iodine,JINK1/2,NOS3,P38 MAPK,SLC5A5 ABCA3,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CEBPD,FASN,ITGB3,PLG,SOD3 11 (6) 5 JINK1/2 MIR17HG,SLC5A5 LAT2 other 2 0.000 3.52E-03 3.26E-02 Akt,ERK,ERK1/2,LAT2,MAPK1,MAPK8,P38 MAPK,PTPN11 ABCA3,ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,CEBPD,DGAT1,FASN,FLNC,IFI44,L1CAM,PLG,PTPRK,RRM2,TNFSF14 18 (8) 7 FCGR1A,LAX1,TREM2 LCP2 CCL3L3,PLC gamma TNFAIP8L2 other 2 1.604 3.53E-03 1.64E-02 Akt,ERK,Jnk,Map3k7,P38 MAPK,TNFAIP8L2 ADGRG6,AIMP2,ANK1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,ITGB3,L1CAM,PLG,RRM2,TNFSF14 14 (6) 5 IFNB1,Map3k7,Pak FZD8 G-protein coupled receptor -0.000 2 -0.577 3.55E-03 1.72E-02 CTNNB1,FZD8,Jnk ACAA1,BIRC3,CD209,CLEC10A,EMX2,FASN,KIFC1,L1CAM,PGK1,PLG,PLIN2,SUSD2 12 (3) 2 8-bromo-cAMP,L-triiodothyronine TJP1 chlorocresol chemical toxicant 3 -1.043 3.56E-03 4.74E-02 Akt,chlorocresol,EGFR,EP300,ERK,ERK1/2,IKK (complex),Jnk,NADPH oxidase,NFkB (complex),P38 MAPK,Ryr,RYR2,SP1 ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,ITGB3,KRT8,L1CAM,PGK1,PLG,RRM2,SNAP25,SOD3,TNFSF14,TNXB 23 (14) 11 Ca2+ YM-024 chemical drug 2 Activated 2.111 3.56E-03 1.09E-02 Akt,AKT1,PIK3CA,YM-024 AIMP2,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,L1CAM,MATR3,PLG,RRM2,TNFSF14 11 (4) 3 AKT1,PIK3CA citalopram chemical drug 2 1.941 3.58E-03 1.48E-02 Akt,citalopram,MAPK8,P38 MAPK,SLC6A4 AIMP2,ANK1,B4GALT1,BIRC2,BIRC3,CEBPD,DGAT1,GNAO1,ITGB3,L1CAM,PLG,RRM2,TNFSF14 13 (5) 4 caspase BCAR4 other 2 -0.775 3.65E-03 2.27E-02 Akt,BCAR4,ERBB2,ERBB3,PTK2 AIMP2,ANGPT2,BIRC2,BIRC3,DPY19L3,FASN,ITGB3,L1CAM,PGK1,PLG,POLI,PTPRK,RRM2,TNFSF14,TNXB 15 (5) 4 quercetin CDH2 Fc receptor group 2 -0.258 3.65E-03 1.77E-02 ERK,ERK1/2,Fc receptor,Focal adhesion kinase,Jnk,MAPK14,MAPK3,NFATC2 ADGRG6,ANGPT2,AOC1,B4GALT1,BBX,BIRC2,CD209,CEBPD,CLEC10A,FASN,ITGB3,KRT8,LRP6,PLG,PTPRK 15 (8) 7 BCAR1,Focal adhesion kinase dalfampridine chemical drug 2 0.535 3.65E-03 2.03E-02 Akt,dalfampridine,MAP2K4,MAPK8,P38 MAPK,Pkc(s),SRC AIMP2,ANK1,B4GALT1,BIRC2,BIRC3,CEBPD,DGAT1,ITGB3,KRT8,L1CAM,PGK1,PLG,RRM2,TNFSF14 14 (7) 6 ATF3,BTG2,CASP3 mir-154 PROCR other 2 Inhibited -2.065 3.70E-03 3.60E-02 Akt,Creb,ERK,ERK1/2,F2R,MAPK14,Mek,P38 MAPK,PRKAA1,PROCR,SRC (family) ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,CASP2,CEBPD,DPY19L3,H2BC21,HSD3B2,IFI44,ITGB3,KRT8,L1CAM,LITAF,LRP6,PLG,RRM2,TNFSF14 19 (11) 11 BHLHE40,HMOX1,WNT3A CCN5 ANGPT1,LIF,PRKAA1,TJP1 F10 lauric acid chemical - endogenous mammalian 2 -0.728 3.70E-03 2.38E-02 Akt,ERK,ERK1/2,Jnk,lauric acid,NFkB (complex) ADGRG6,AIMP2,ALDH7A1,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,L1CAM,PLG,RRM2,SOD3,TNFSF14 17 (6) 5 beta-naphthoflavone Ca2+,CCL3L3,NFkB (complex) SAA group 2 -1.091 3.72E-03 3.86E-02 Akt,ERK,ERK1/2,Jnk,NFkB (complex),NFKB1,P38 MAPK,PLA2G2A,PLIN1,RELA,SAA,TLR2 ADGRG6,AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,ASPG,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,GNAO1,ITGB3,L1CAM,PLG,RRM2,SOD3,TNFSF14 21 (12) 11 CXCL10,IL31 PPARA Cebp CASP3,phospholipid,TFPI IL22R1-IL10R2 complex 2 -1.604 3.74E-03 1.81E-02 Akt,ERK1/2,IL22R1-IL10R2,Jnk,P38 MAPK AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,L1CAM,PLG,RRM2,TNFSF14 14 (5) 4 LPAR1 G-protein coupled receptor 2 -1.789 3.74E-03 3.47E-02 Akt,AKT1,ERK,G protein alphai,Jnk,LPAR1,MAPK1,MAPK8,P38 MAPK,PI3K (complex) ADGRG6,AIMP2,ANK1,B4GALT1,BIRC2,BIRC3,CD209,CLEC10A,DGAT1,FASN,FLNC,HNRNPM,IFI44,ITGB3,L1CAM,MATR3,PLG,PTPRK,RRM2,TNFSF14 20 (10) 9 BHLHE40,ziritaxestat zoledronic acid AKT1,SPHK1 buserelin biologic drug 2 -1.000 3.74E-03 2.72E-02 buserelin,ERK,ERK1/2,Jnk,MAP2K1,MAPK1,MAPK3,PTGS1,RAF1 ADGRG6,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FLNC,IFI44,ITGB3,PLG,PTPRK,RRM2,SLC16A7 16 (9) 8 Ca2+ SLC30A7 transporter 0.000 2 Inhibited -2.111 3.77E-03 1.21E-02 Akt,AKT1,IRS2,SLC30A7 AIMP2,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,L1CAM,MATR3,PLG,RRM2,TNFSF14 11 (4) 3 mir-182 AKT1 fatty acid Complement complex 2 -0.632 3.78E-03 1.13E-02 ADM,Complement,ERK,Jnk,MAPK8 ADGRG6,B4GALT1,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,ITGB3,PGK1,PLG 10 (5) 4 ammonium,C5,Complement component 1,IgG NMDA Receptor,PROS1 PDGFB delta-tocopherol chemical - endogenous mammalian 2 1.897 3.78E-03 7.10E-03 AKT1,delta-tocopherol,ERK1/2 ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,ITGB3,MATR3,PLG 10 (3) 2 CASP3 AKT1,Ca2+ levmetamfetamine chemical drug 3 -0.218 3.78E-03 3.89E-02 Akt,BCL2,CYP1A2,ERK1/2,levmetamfetamine,MAPK1,MAPK3,NFkB (complex),Pkc(s),PRKCE,rasagiline,selegiline AIMP2,ALDH7A1,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CACHD1,CHRNB3,FLNC,GSTM3,IFI44,ITGB3,KRT8,L1CAM,PLG,PTPRK,RRM2,SNAP25,SOD3,TNFSF14 21 (12) 9 tanespimycin chemical drug 1 1.342 3.79E-03 6.80E-03 tanespimycin BIRC3,CALM1 (includes others),FASN,HNRNPM,KRT8 5 (1) 1 CASP3,KRT18,LRP6,PDGFRA,SLC2A1 AKT1,ATF2,CALM1 (includes others),Hsp90,KIT,MAP3K7,NFkB (complex),SCD,TERT PLA2G6 enzyme -0.000 2 -1.500 3.82E-03 2.73E-02 Akt,AKT1,Creb,Jnk,MAPK9,P38 MAPK,PLA2G6 AIMP2,ANK1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,DPY19L3,FASN,HNRNPM,ITGB3,L1CAM,MATR3,PLIN2,SOD3,TNFSF14 16 (7) 6 Ca2+ daunorubicin,MAP4K4 AKT1,IRS1,NOX1,NOX4 DIPQUO chemical reagent 2 -0.535 3.83E-03 2.14E-02 CTNNB1,DIPQUO,GSK3B,MAPT,P38 MAPK ACAA1,ANK1,ASPG,BIRC2,BIRC3,CEBPD,EMX2,FASN,ITGB3,KIFC1,L1CAM,PGK1,PLIN2,SUSD2 14 (5) 4 GPAT3 enzyme 2 1.000 3.84E-03 2.60E-03 EIF4EBP1,GPAM,GPAT3,p70 S6k CEBPD,DGAT1,FASN,PLIN2 4 (4) 4 DYSF GPAM CREB3L3 transcription regulator 2 0.277 3.86E-03 1.86E-02 Akt,CREB3L3,INSR,IRS1,PRKCE AIMP2,BIRC2,BIRC3,CEBPD,CHRNB3,DGAT1,FASN,FCGBP,HSD3B2,L1CAM,PLG,RRM2,TNFSF14 13 (5) 4 bile acid,CYP2B6,LPIN1 IRS1 lead chemical toxicant 2 -0.832 3.86E-03 1.67E-02 Akt,Ap1,Jnk,lead,MAPT,NOS2 AIMP2,ASPG,BIRC2,BIRC3,CALM1 (includes others),CD209,CLEC10A,FASN,GSTM3,L1CAM,PLG,RRM2,TNFSF14 13 (6) 6 hydrogen sulfide Ca2+,CASP3,PGR Collagen type II,PPP5C VEGFB growth factor 2 -1.807 3.86E-03 2.08E-02 Akt,ERK1/2,Jnk,P38 MAPK,SRC (family),VEGFB AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CASP2,CD209,CEBPD,CLEC10A,ITGB3,L1CAM,PLG,RRM2,TNFSF14 15 (6) 6 SETD2,sildenafil CA4,DIO2,EHHADH,PLD1,SOD1 ATF3 SAR1B enzyme -0.000 3 Inhibited -2.183 3.89E-03 2.54E-02 CTNNB1,ERK1/2,HMOX1,MAPK1,Pld,SAR1B ACAA1,ANGPT2,ANGPTL3,AOC1,BIRC2,BIRC3,EMX2,FASN,FLNC,IFI44,KIFC1,L1CAM,PGK1,PLIN2,PTPRK,SUSD2,TNFSF14 17 (6) 5 PPARA hesperetin chemical drug 2 0.471 3.90E-03 3.92E-02 Akt,Creb,CYP1A1,CYP1B1,estrogen receptor,hesperetin,Jnk,MAPK3,NOS3,Pkc(s),SMAD3,SOAT1,SRC (family) AIMP2,B4GALT1,BIRC2,CACHD1,CD209,CLEC10A,DGAT1,DPY19L3,FASN,FLNC,GSTM3,ITGB3,KRT8,L1CAM,PLG,PTPRK,SOD3,TNFSF14 18 (13) 12 prostaglandin E2 chemical - endogenous mammalian 1 -0.707 3.92E-03 9.90E-03 prostaglandin E2 ANGPT2,BIRC3,CALCRL,CASP2,CEBPD,FASN,HSD3B2,TNFSF14 8 (1) 1 captopril,ceramide,chenodeoxycholic acid,ciprofloxacin,IgG,irinotecan,mevastatin,N-acetylmuramyl-L-alanyl-D-isoglutamine,NCX-4040,PNPLA8,PRNP,SOD1,taurocholic acid,WNT1 3-methyladenine,6-hydroxydopamine,arginine,capsazepine,CNTF,dibenzoylmethane,edaravone,FFAR4,indomethacin,infliximab,lactacystin,LOC102724788/PRODH,naproxen,NTN1,plumbagin,prednisolone,quercetin,racemic flurbiprofen,rofecoxib,suramin,YM-58483 AKT1,ANGPT1,ANGPTL4,ATF2,CCR7,Cofilin,CYP19,Focal adhesion kinase,HAS2,IBSP,Na+,K+ -ATPase,NR5A2,PENK,PGF,Secretase gamma,SOCS3,VEGFC CASP3,CCL3L3,CXCL10,IFNB1,KLRC4-KLRK1/KLRK1,MAPK7,PIK3CG,PPP1R15A,TJP1 PEMT enzyme -0.000 2 0.000 3.96E-03 1.56E-02 Akt,ERN1,PEMT AIMP2,BIRC2,CEBPD,DGAT1,FASN,L1CAM,PLG,PLIN2,RRM2,TNFSF14 10 (3) 2 phytohemagglutinin,SCD choline ERN1 3',4',7-trihydroxyisoflavone chemical - endogenous non-mammalian 2 Activated 2.500 3.99E-03 2.48E-02 3',4',7-trihydroxyisoflavone,Akt,AKT1,Ap1,CDK2,RB1 AIMP2,ANGPT2,CALCRL,CALM1 (includes others),CEBPD,CELSR1,FASN,H2BC21,HNRNPM,L1CAM,MAPK4,MATR3,PLG,RRM2,SNAP25,TNFSF14 16 (6) 5 ESR2 AKT1,CCNE1 HAS2 enzyme 2 -0.258 3.99E-03 2.59E-02 Akt,ERBB2,ERBB3,Focal adhesion kinase,HAS2 AIMP2,ANGPT2,BIRC2,DPY19L3,FASN,ITGB3,KRT8,L1CAM,PGK1,PLG,POLI,PTPRK,RRM2,TNFSF14,TNXB 15 (5) 4 22(R)-hydroxycholesterol,FGF7,forskolin,Map3k7,NFkB (complex),NOX4,prostaglandin E2,WNT3A doramapimod,INHA,KN 93 Focal adhesion kinase,PROX1 DRD3 G-protein coupled receptor 2 0.832 4.00E-03 1.76E-02 AKT1,DRD3,ERK1/2,MAPK1,MAPK3 ANGPT2,AOC1,B4GALT1,BIRC2,CEBPD,FASN,FLNC,HNRNPM,IFI44,ITGB3,MATR3,PLG,PTPRK 13 (5) 4 AKT1,SLC6A3 F10 peptidase 2 1.213 4.01E-03 2.63E-02 ERK1/2,F10,F2R,F5,HGF,MAPK1,MAPK14,MAPK3,MAPK8 AOC1,B4GALT1,CALCRL,CALM1 (includes others),CEBPD,CELSR1,DGAT1,FASN,FLNC,IFI44,ITGB3,KRT8,L1CAM,LGMN,LRP6,MMRN1,PTPRK 17 (9) 8 Pdi,phospholipid Ca2+,PROCR,TFPI SU1498 chemical drug 2 0.535 4.01E-03 1.80E-02 ERK,ERK1/2,Jnk,MAPK1,MAPK3,SU1498 ADGRG6,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FLNC,IFI44,ITGB3,PLG,PTPRK 14 (6) 6 YM-58483 chemical reagent 3 0.000 4.01E-03 4.06E-02 AKT1,CCND1,CSF2,GATA4,MEF2A,MEF2D,Nfat (family),NFAT5,NFATC1,NFATC2,TRPC5,YM-58483 AOC1,B4GALT1,BBX,BIRC3,CASP2,CD209,CEBPD,EMX2,FASN,HNRNPM,HSD3B2,IFI44,ITGB3,MATR3,PLG,PLIN2,PTPRK,RRM2,SOD3,TNFSF14 20 (12) 10 CASP3,prostaglandin E2 DSCAM other 0.000 2 0.333 4.01E-03 1.15E-02 DSCAM,Jnk,MAPK8 B4GALT1,BIRC3,CD209,CLEC10A,DGAT1,L1CAM,NLGN2,PLG,SYT12 9 (3) 3 NTN1,PGR Pak,PDGFB,PLD1,RGMA,SFRP1,WNT16 IRS1,SEMA7A C5 other 2 -0.688 4.02E-03 3.13E-02 Akt,C5,ERK1/2,MAPK1,MAPK14,MAPK3,STAT3 AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,FASN,FLNC,IFI44,ITGB3,L1CAM,LRP6,PGK1,PLG,PTPRK,RRM2,TNFSF14 19 (7) 6 Complement,SOCS3 MSTN growth factor 2 -0.500 4.07E-03 2.58E-02 Akt,ERK1/2,Jnk,MSTN,Nfat (family),NPAT,P38 MAPK,SMAD3 AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,H2BC21,ITGB3,L1CAM,PTPRK,RRM2,TNFSF14 16 (8) 7 AKT1,NFkB (complex),SENP2 suramin ATF2,SLC2A1 BMP7,CAV3,IBSP ACSL1 enzyme 2 0.000 4.10E-03 1.80E-02 ACSL1,Akt,fatty acid,IRS1,MAPK8,MAPK9 AIMP2,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,DGAT1,L1CAM,PLG,RRM2,SOD3,TNFSF14 12 (6) 5 HNF4A,indomethacin,L-triiodothyronine,PGR,POR,PPARA,RAB2A,Srebp,telmisartan 25-hydroxycholesterol,BMP7,EHHADH,HSD17B4,N-cor,triacsin C,tributyltin fatty acid,IRS1 CASP3 CDK4/6 group 2 -0.471 4.13E-03 3.64E-02 Akt,CDK2,CDK4/6,CDKN1A,EIF4EBP1,FOXM1,GSK3B,MTOR,p70 S6k,RB1,RBL2 AIMP2,ANGPT2,BIRC3,CALCRL,CEBPD,CELSR1,FASN,GLB1,H2BC21,ITGB3,KIFC1,L1CAM,MAPK4,PGK1,PLG,RRM2,SNAP25,TNFSF14 18 (11) 11 CDKN2A AHNAK,NCOA3,RRM2 HSPB1,KRT10,LASP1 NPHS1 other 0.000 2 -1.941 4.15E-03 1.55E-02 Akt,Ap1,Jnk,NPHS1,P38 MAPK AIMP2,ANK1,BIRC2,BIRC3,CALM1 (includes others),CD209,CEBPD,CLEC10A,ITGB3,L1CAM,PLG,RRM2,TNFSF14 13 (5) 4 BMP7,CD2AP,MAGI2,mefunidone,telmisartan [D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin,FGF4,ouabain Cofilin,TJP1 Ck2 alpha group 1 -1.414 4.15E-03 9.90E-03 Ck2 alpha BIRC2,BIRC3 2 (1) 1 GPI,MDM2,NFkB (complex) CXCL10 STK24 kinase 0.000 1 0.000 4.15E-03 1.07E-02 STK24 DGAT1,FASN 2 (1) 1 caspase,ESR2 IgG GPAM SOCS6 other 2 1.291 4.16E-03 2.40E-02 Akt,ERK1/2,MAPK14,P38 MAPK,SOCS6,STAT5A AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CASP2,CEBPD,HSD3B2,ITGB3,L1CAM,LRP6,PLG,RRM2,TNFSF14 15 (6) 6 IFNB1,IRS1 vildagliptin chemical drug 2 -1.508 4.16E-03 1.28E-02 Akt,AKT1,NOS3,vildagliptin AIMP2,BIRC2,BIRC3,CEBPD,HNRNPM,L1CAM,MATR3,PLG,RRM2,SOD3,TNFSF14 11 (4) 3 AKT1,Ca2+ NPY IL11 cytokine 2 -0.426 4.20E-03 4.94E-02 Akt,ERK1/2,IL11,IL6ST,JAK,Jnk,MAPK1,MAPK3,P38 MAPK,STAT,STAT1,STAT3,STAT5A AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,CD209,CEBPD,CGAS,CLEC10A,FASN,FLNC,HSD3B2,IFI44,ITGB3,L1CAM,PGK1,PLG,PTPRK,RRM2,SLC5A7,TNFSF14 22 (13) 12 8-bromo-cAMP,CDKN2A,forskolin (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester,BCLAF3,capsazepine,GAST,HOXA10,tributyltin CASP3,caspase,Il11r,SOCS3,SPHK1,WNT5A C1QTNF12 other -0.000 2 -1.897 4.21E-03 8.60E-03 AKT1,C1QTNF12,ERK1/2,IRS1 ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,ITGB3,MATR3,PLG 10 (4) 3 tunicamycin AKT1,IRS1 Rab5 group 2 -1.155 4.27E-03 1.17E-02 AKT1,ERK1/2,Rab5,RGS4,SREBF2 ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,HNRNPM,ITGB3,MATR3,MEGF6,PLG,REG1A,SSPOP 12 (5) 4 Focal adhesion kinase,PIK3CD,RABGEF1 AKT1 RGS4 sodium azide chemical toxicant 2 1.155 4.27E-03 1.51E-02 AKT1,MAPK1,MAPK8,sodium azide B4GALT1,BIRC3,CEBPD,DGAT1,FASN,FLNC,HNRNPM,IFI44,ITGB3,MATR3,PLG,PTPRK 12 (4) 3 CDKN2A,SLC2A1 AKT1,aldehyde GNAI3 enzyme 2 0.243 4.29E-03 3.14E-02 Akt,ERK1/2,GNAI3,Gsk3,IRF3,Jnk,MAPK1,MAPK14,MAPK3 AIMP2,ANGPT2,ANOS1,AOC1,B4GALT1,CD209,CEBPD,CLEC10A,FASN,FLNC,ITGB3,L1CAM,LRP6,PLG,PTPRK,RRM2,TNFSF14 17 (9) 8 8-bromo-cAMP,BHLHE40,CCR7,GPSM1,quercetin,reserpine,RGS4 acetylcholine,captopril,ICI 118,551 CCL3L3 SORBS3 other 2 -0.426 4.31E-03 4.20E-02 AR,ESR2,Jnk,MAPK1,NR3C1,SORBS3 ANK1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,Cyp2d22,DUT,FLNC,GLB1,HSD3B2,IFI44,ITGB3,KRT8,MAPK4,MEGF10,PLG,PTPRK,RRP12,SLC5A7,SOD3 22 (6) 5 ESR2 [D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin chemical reagent 2 0.229 4.32E-03 4.03E-02 [D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin,AKT1,EGFR,ERK,ERK1/2,MAPK1,MAPK3,PRKCE,RGS4,SRC ADGRG6,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CHRNB3,FASN,FLNC,HNRNPM,IFI44,ITGB3,MATR3,MEGF6,PGK1,PLG,PTPRK,SSPOP,TNXB 19 (10) 9 AKT1,Ca2+,CXCL10,G protein,OPRK1,RPS6KB1 CD2AP,NPHS1,RGS4 phosphatidylinositol 3,4-diphosphate chemical - endogenous mammalian 2 Inhibited -2.111 4.34E-03 1.59E-02 Akt,AKT1,phosphatidylinositol 3,4-diphosphate AIMP2,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,L1CAM,MATR3,PLG,RRM2,TNFSF14 11 (3) 2 NTRK1,Pi3k class I,PIK3CA,PIK3CD AKT1,PLD1 CASP3 varespladib chemical drug 3 0.655 4.36E-03 3.80E-02 ALOX5,ERK,ERK1/2,Jnk,MAPK1,MAPK14,MAPK3,MAPK8,NFkB (complex),NR1H3,P38 MAPK,PLA2G10,PLA2G2A,PLA2G5,PROC,varespladib ADGRG6,ALDH7A1,ANGPT2,ANGPTL3,ANK1,AOC1,ASPG,B4GALT1,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FASN,FLNC,IFI44,ITGB3,LRP6,PLG,PTPRK,SOD3 21 (16) 13 DIO2 enzyme 2 -0.577 4.38E-03 1.30E-02 Akt,DIO2,levothyroxine,TG,thyroid hormone AIMP2,ANGPT2,BIRC2,FASN,ITGB3,L1CAM,PLG,RRM2,SERINC2,SYCE2,SYT12,TNFSF14 12 (5) 5 8-bromo-cAMP,bile acid,CAMP,deferoxamine,forskolin,phosphate,PPARA,SYVN1,USP33,VEGFB CIDEC,PLCL1,prazosin,Sik1,triiodothyronine, reverse,tunicamycin SEMA7A DIO1 sanguinarine chemical - endogenous non-mammalian 2 0.218 4.43E-03 4.74E-02 Akt,Ap1,DUSP1,MAPK8,NFkB (complex),NFKBIA,sanguinarine,STAT3 AIMP2,ALDH7A1,ANGPT2,CALM1 (includes others),CD209,CEBPD,CLEC10A,DGAT1,FASN,IFI44,KRT8,L1CAM,LITAF,NCAN,PGK1,PLG,PLIN2,PTPRK,RRM2,SOD3,TNFSF14 21 (8) 7 CASP3,caspase,HMOX1 FASLG,NFkB (complex) etoposide chemical drug 1 -1.633 4.44E-03 7.10E-03 etoposide BIRC2,BIRC3,CASP2,FASN,SLC16A4,WRN 6 (1) 1 4-phenylbutyric acid ACHE,ADAM10,ATF2,ATF3,ATR,Ca2+,CASP3,caspase,CDKN2A,CSNK1D,FASLG,Histone h2a,IFNB1,MAP3K7,MERTK,MME,NFkB (complex),NPY,POU5F1,Sapk,SENP2 HIPK2,MDM2,RPS6KB1,SPHK1,TERT Dishevelled group 2 1.291 4.44E-03 2.61E-02 CTNNB1,Dishevelled,GSK3B,Jnk,MAPK8,MAPT,Pkc(s) ACAA1,ASPG,B4GALT1,BIRC2,CD209,CLEC10A,DGAT1,EMX2,KIFC1,KRT8,L1CAM,PGK1,PLG,PLIN2,SUSD2 15 (7) 6 Frizzled,WNT3A CAMK2,PIP5K1B SALL4 transcription regulator 3 Inhibited -2.673 4.44E-03 2.60E-02 AKT1,ATM,ETS2,POU5F1,SALL4,SNAI2 ABCA3,BIRC2,BIRC3,CASP2,CEBPD,FASN,FLNC,GLB1,HNRNPM,L1CAM,MATR3,MKX,PLG,RRM2 14 (6) 6 CDX1,NCOA3 TSC22D3 BTG2,CCND2,E2F2,LCP2,SEMA6A,SFRP1 ADAM10,ANGPTL4,CCN5,CDH2,LASP1,PDGFC,WNT3A,WNT5A PRKD3 kinase 0.000 2 -1.941 4.46E-03 1.60E-02 Akt,ERK,ERK1/2,MTORC1,PRKD3,RTKN,SPHK2 ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,ITGB3,L1CAM,PLG,RRM2,TNFSF14 13 (7) 6 GAST kb-NB 142-70 RPS6KB1 PRR14 other 2 Inhibited -2.111 4.47E-03 1.46E-02 Akt,ERK,p70 S6k,PDPK1,PRR14 ADGRG6,AIMP2,BIRC2,CEBPD,FASN,ITGB3,L1CAM,PLG,RAB11A,RRM2,TNFSF14 11 (5) 4 MAGI2 enzyme 2 1.500 4.50E-03 2.48E-02 Akt,AKT1,MAGI2,PTEN ACAA1,AIMP2,ANGPT2,BIRC2,BIRC3,CALCRL,CEBPD,CELSR1,FASN,HNRNPM,L1CAM,MATR3,PGK1,PLG,RRM2,TNFSF14 16 (4) 3 NPHS1 AKT1 ARHGAP32 other 0.000 2 Inhibited -2.111 4.53E-03 1.11E-02 AKT1,ARHGAP32,ERK1/2,RAS ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,ITGB3,MATR3,PLG 11 (4) 3 NMDA Receptor AKT1 vatalanib chemical drug 2 Activated 2.138 4.54E-03 1.93E-02 Akt,AKT1,ERK1/2,KDR,Pdgf (complex),vatalanib AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,ITGB3,L1CAM,MATR3,PLG,RRM2,TNFSF14 14 (6) 5 CASP3 AKT1,CCNE1,KIT BRD7 transcription regulator -0.000 2 1.134 4.58E-03 7.90E-03 AKT1,BRD7 BIRC3,CEBPD,FASN,HNRNPM,KRT8,MATR3,PLG 7 (2) 2 MDM2 AKT1 Ca2 ATPase group 2 Activated 2.000 4.59E-03 7.80E-03 ATP2A2,ATP2B2,Ca2 ATPase FASN,FLNC,RAB11A,SOD3 4 (3) 2 Ca2+ rhodioloside chemical - endogenous non-mammalian 2 0.000 4.61E-03 1.59E-02 Akt,Jnk,P38 MAPK,p70 S6k,rhodioloside AIMP2,ANK1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,ITGB3,L1CAM,RRM2,TNFSF14 12 (5) 4 HMOX1 CASP3 ganglioside chemical - endogenous mammalian 2 -0.853 4.62E-03 4.99E-02 CaMKII,ERK,ganglioside,MAPK1,MAPK14,MAPK8,NFkB (complex),NFKB1,P38 MAPK,PTPN11,STAT1,STAT3 ABCA3,ADGRG6,ALDH7A1,ANGPT2,ANK1,B4GALT1,BIRC2,BIRC3,CASP2,CD209,CEBPD,DGAT1,FASN,FLNC,GNAO1,IFI44,ITGB3,LRP6,PGK1,PTPRK,RRM2,SOD3 22 (12) 11 tunicamycin CASP3,NFkB (complex),NTRK1 edaravone chemical drug 2 Activated 2.183 4.64E-03 2.70E-02 edaravone,EIF2AK3,Jnk,MAPK14,MAPK8,MAPT,P38 MAPK,STAT3 ANGPT2,ANK1,ASPG,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FASN,ITGB3,LRP6,PGK1,PLG,PNLIP,RRM2 17 (8) 8 CASP3,prostaglandin E2 protoporphyrin IX chemical - endogenous mammalian 3 0.728 4.64E-03 3.46E-02 26s Proteasome,ERK1/2,HIF1A,HMOX1,Ho,Jnk,mitomycin C,Nos,NOS2,NOS3,PRKCD,protoporphyrin IX,Thioredoxin reductase ADRM1,ANGPT2,ANGPTL3,AOC1,BIRC2,CD209,CLEC10A,FASN,ITGB3,L1CAM,PGK1,PLG,SLC16A4,SOD3,TMPRSS6,TNFSF14,TULP4 17 (13) 9 HMOX1 cryptotanshinone chemical drug 2 0.447 4.64E-03 3.40E-02 ACHE,Akt,AR,cryptotanshinone,ERK,ERK1/2,Jnk,MAP3K7,PTPN11 ABCA3,ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,CD209,CEBPD,CLEC10A,Cyp2d22,FASN,HSD3B2,IFI44,ITGB3,L1CAM,PLG,RRM2,SLC5A7,SOD3,TNFSF14 20 (9) 8 ADAM10 ACHE,CASP3,MAP3K7 D-galactose chemical - endogenous mammalian 3 -0.333 4.67E-03 1.04E-02 ACHE,ALOX5,D-galactose,glutathione peroxidase,Gsk3,GSTK1,GSTT1,MAPT,MMP2,PRKCE ASPG,BIRC3,CGAS,CHRNB3,FASN,GSTM3,ITGB3,PLG,SLC5A7 9 (10) 8 ACHE MYZAP other 2 -1.069 4.70E-03 2.86E-02 CTNNB1,ERK,GSK3B,MYZAP,P38 MAPK ACAA1,ADGRG6,ANK1,BIRC2,BIRC3,CEBPD,EMX2,FASN,ITGB3,KIFC1,L1CAM,PGK1,PLIN2,SUSD2 14 (5) 4 CDH2,TJP1 alpha-estradiol chemical - endogenous mammalian 2 -0.943 4.70E-03 3.02E-02 Akt,alpha-estradiol,EGFR,ERK,ERK1/2,MAPK1,MAPK3 ADGRG6,AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,FASN,FLNC,IFI44,ITGB3,L1CAM,PLG,PTPRK,RRM2,TNFSF14,TNXB 18 (7) 6 Ca2+,CYP2B6,PGR STAM2 other 2 1.732 4.73E-03 1.63E-02 Akt,Jnk,P38 MAPK,STAM2 AIMP2,ANK1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,L1CAM,PLG,RRM2,TNFSF14 12 (4) 3 deguelin chemical drug 2 1.941 4.74E-03 2.12E-02 Akt,AKT1,deguelin,PRKAA,SMAD3 AIMP2,BIRC2,BIRC3,CEBPD,DGAT1,FASN,HNRNPM,L1CAM,MATR3,PLG,PTPRK,RRM2,TNFSF14 13 (5) 4 ceramide AKT1 BHLHE40 transcription regulator 1 Activated 2.121 4.74E-03 1.94E-02 BHLHE40 ALDH7A1,CALCRL,FASN,GSTM3,KRT8,PGK1,PLIN2,SCARF1 8 (1) 1 cocaine,deferoxamine,EPAS1,forskolin,IFNB1,Map3k7,quercetin,S100A9,SYVN1 ATF3,CASP3,CCR7,EXT1,FPR1,FRZB,GNAI3,HAS1,ITGA4,KDM3A,LCP2,LGALS3BP,LIF,LPAR1,MERTK,PLAC8,PROCR,RASGRP1,RGS16,SDC4,SLC2A1,SOCS3 KIT,KRT18,TFF2 barium chemical reagent 2 -0.333 4.75E-03 1.61E-02 barium,ERK,Focal adhesion kinase,Jnk,SRC ADGRG6,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,KRT8,PGK1,PLG 9 (5) 4 Focal adhesion kinase,PENK PPP1CA phosphatase -0.683 2 Activated 2.065 4.76E-03 4.79E-02 AKT1,EIF2AK2,MAPK1,MAPK3,PPP1CA,RAF1,RB1,TAFAZZIN ADRM1,ANGPT2,B4GALT1,BIRC2,BIRC3,CALCRL,CEBPD,CELSR1,FASN,FLNC,H2BC21,HNRNPM,ITGB3,MAPK4,MATR3,PLG,PTPRK,RRM2,SLC16A7 19 (8) 7 CASR,PPP1R9B,RGL1 CDH2 AKT1,ITPR1,LRRK2 CDH2 other 2 -0.943 4.83E-03 3.84E-02 Akt,CDH2,ERK1/2,FOXO1,MAPK1,PRKAA1 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CASP2,CEBPD,FLNC,H2BC21,HSD3B2,IFI44,ITGB3,L1CAM,LITAF,PLG,PTPRK,RRM2,TNFSF14 18 (6) 5 ADAM10,BCAN,BCAR4,ESR2,Focal adhesion kinase,forskolin,JINK1/2,MFAP5,MGAT5,MYZAP,POU5F1,PPP1CA,PPP3CA,PTAFR,PTTG1,ZEB2 4-hydroxycinnamyl aldehyde,FGFR4,MAPK7,MGAT3,mir-145,MK2206,NET1,PCGF2,PF-573228,SALL4,SETD2,suramin,TERT,WNT3A PRKAA1 FGF4 growth factor 2 -1.414 4.83E-03 3.64E-02 ERK,ERK1/2,FGF4,FGFR2,Jnk,MAPK1,P38 MAPK,RAF1 ADGRG6,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,CUBN,FLNC,IFI44,ITGB3,PLG,PTPRK,RRM2,SLC16A7,TENM3 18 (8) 7 LIF,NCOA3 HSD17B4 Ca2+,PLC gamma,PTTG1,SCD FOXO4,NPHS1,SOSTDC1 ZG16B other 2 -0.905 4.85E-03 1.30E-02 Akt,ERK1/2,NOS3,ZG16B AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,SOD3,TNFSF14 11 (4) 3 ITSN1 other 0.000 2 -1.698 4.86E-03 3.87E-02 Akt,EGFR,ERK,ERK1/2,ITSN1,MAPK8,P38 MAPK ADGRG6,AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,DGAT1,FASN,ITGB3,L1CAM,PLG,RRM2,TNFSF14,TNXB 17 (7) 6 camptothecin SATB2 transcription regulator 0.000 1 1.732 4.87E-03 1.15E-02 SATB2 ADGRG6,IFI44,KRT8 3 (1) 1 CNTF MFAP2,NOX4 CXCL10 gambogic acid chemical - endogenous non-mammalian 1 1.414 4.88E-03 6.70E-03 gambogic acid BIRC2,BIRC3 2 (1) 1 CASP3,caspase NFkB (complex),TRAF1 gamma-linolenic acid chemical - endogenous mammalian 1 1.414 4.88E-03 8.50E-03 gamma-linolenic acid FASN,PLIN2 2 (1) 1 SCD Ca2+,HMOX1 BCOR transcription regulator 2 0.000 4.88E-03 3.48E-02 ADM,BCOR,BMP7,CD44,CEBPA,COL18A1,DLX6,FOXA2,HOXB7,HOXC6 ABCA3,ANGPT2,BIRC2,BIRC3,CEBPD,EMX2,FASN,GSTM3,ITGB3,LITAF,MEGF10,MMRN1,PGK1,PLIN2,POU3F3,PTK7 16 (10) 10 BMP7,FOXQ1,Histone h2a 1'-acetoxychavicol acetate chemical reagent 2 1.147 4.88E-03 4.09E-02 1'-acetoxychavicol acetate,Ap1,Creb,ERK1/2,JINK1/2,NFkB (complex),NFKB1,NFKBIA ALDH7A1,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CALM1 (includes others),CD209,CEBPD,DPY19L3,FASN,GNAO1,ITGB3,KRT8,LITAF,NCAN,PLG,RRM2,SOD3 19 (8) 8 JINK1/2,NFkB (complex) S100A9 other 2 -0.447 4.88E-03 4.30E-02 CHEK1,ERK1/2,Jnk,MAPK1,NFkB (complex),P38 MAPK,REL,S100A9,TERT AGA,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BCHE,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,DUT,FLNC,GLB1,ITGB3,PLG,PTPRK,RRM2,SOD3 20 (9) 9 ADAM10,CASR,peptidoglycan,PPARA,SAA1 Map3k7,SCD BHLHE40,CASP3,CXCL10,DYRK3,IFNB1,MMP7,NFkB (complex),PDGFC,SOCS3,TERT,USP18 ATF2,ATF3,CCN5,LOC102724788/PRODH,PIK3IP1,SEMA3B 1,1,2,2-tetrachloroethane chemical toxicant 2 -0.816 4.91E-03 1.10E-02 1,1,2,2-tetrachloroethane,CYP1A1,CYP1A2,HMOX1 ANGPT2,ANGPTL3,CACHD1,GSTM3,ITGB3,TNFSF14 6 (4) 3 HMOX1 LINC00461 other 2 -1.508 4.92E-03 1.47E-02 Akt,ERK1/2,LINC00461 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,TMEM161B,TNFSF14 11 (3) 3 canertinib chemical drug 2 1.414 4.92E-03 3.55E-02 Akt,AKT1,canertinib,EGFR,ERBB2,ERBB4 AIMP2,ANGPT2,BIRC2,BIRC3,CEBPD,DPY19L3,FASN,HNRNPM,ITGB3,L1CAM,MATR3,PGK1,PLG,POLI,PTPRK,RRM2,TNFSF14,TNXB 18 (6) 5 AKT1 rofecoxib chemical drug 2 0.500 4.93E-03 3.65E-02 Ap1,ETS1,Jnk,MAPK3,MMP2,NFkB (complex),NOS2,P38 MAPK,PTGS2,rofecoxib ALDH7A1,ANGPT2,ANK1,B4GALT1,BIRC2,BIRC3,CALM1 (includes others),CD209,CEBPD,CLEC10A,FASN,ITGB3,KRT8,PLG,RRM2,SOD3 16 (10) 10 NFkB (complex),prostaglandin E2,VEGFC IL13RA2-CHI3L1 complex 2 -0.905 4.98E-03 1.48E-02 Akt,ERK1/2,IL13RA2,IL13RA2-CHI3L1 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CLEC10A,ITGB3,L1CAM,PLG,RRM2,TNFSF14 11 (4) 3 CGP 74514A chemical drug 2 0.728 5.00E-03 4.02E-02 Akt,CGP 74514A,ERK1/2,FOXO1,Gsk3,P38 MAPK,RB1 AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CALCRL,CASP2,CEBPD,CELSR1,FASN,H2BC21,L1CAM,MAPK4,PLG,RRM2,TNFSF14 17 (7) 6 CASP3 RPS6KB1 linsidomine chemical drug 2 Inhibited -2.357 5.06E-03 4.14E-02 Ap1,CEBPB,ERK,ERK1/2,ETV4,GSK3B,HMOX1,IDH1,linsidomine,MAPK14,MAPK8,MAPT,PTGS1 ADGRG6,ANGPT2,ANGPTL3,AOC1,ASPG,B4GALT1,BIRC2,BIRC3,CALM1 (includes others),DGAT1,DUT,FASN,ITGB3,LGMN,LRP6,PLG,RRM2,TNFSF14 18 (13) 12 carbon monoxide,CDKN2A,HMOX1,PPARD Ca2+,FASLG,OPRK1 CAPNS1 peptidase 2 -0.728 5.10E-03 3.41E-02 Akt,CAPNS1,ERK1/2,Jnk,NFkB (complex),P38 MAPK AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,L1CAM,PLG,RRM2,SOD3,TNFSF14 17 (6) 5 ammonium CASP3,CCND2,p85 (pik3r) PIK3CA ESR2 ligand-dependent nuclear receptor 1 -0.905 5.12E-03 2.71E-02 ESR2 ANK1,B4GALT1,CEBPD,DUT,GLB1,IFI44,KRT8,MAPK4,MEGF10,RRP12,SLC5A7 11 (1) 1 3',4',7-trihydroxyisoflavone,equol,forskolin,Hsp90,L-triiodothyronine,quercetin,SORBS3,TEX11 CGB3 (includes others),MDM2,NR0B1,RGS4,WNT5A Ca2+,CCNE1,CD93,CDH2,CKS1B,DAB2,FGF19,FSTL1,IBSP,IL20,MGAT3,MME,NCOA3,NRP2,RETN,SCD,SCGB3A1,SDC4,SOST,STK24,TAT,TJP1 BTG2,ERN1,FOXQ1,INPP4B,KIT,LGALS3BP,LHB,NFkB (complex),NPY,NTRK1,PGR,SPHK1,USP19 RHOG enzyme 2 Inhibited -2.138 5.19E-03 2.67E-02 Akt,AKT1,ERK,ITGB3,Jnk,RHOG ADGRG6,AIMP2,BIRC2,CD209,CEBPD,CLEC10A,FASN,HNRNPM,ITGB3,L1CAM,MATR3,PLG,RRM2,TNFSF14 14 (6) 5 PDGFB,VAV1 HOXA10 AKT1 CGP77675 chemical drug 2 0.632 5.20E-03 1.12E-02 CGP77675,ERK1/2,Jnk,SRC,SRC (family),STAT ANGPT2,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PGK1,PLG 10 (6) 5 phorbol-12,13-diacetate chemical reagent 2 -1.698 5.24E-03 3.31E-02 CYP19A1,ERK,ERK1/2,Histone h3,JUN,MAPK1,MAPK8,P38 MAPK,phorbol-12,13-diacetate ADGRG6,ANGPT2,ANK1,AOC1,ASPG,B4GALT1,BIRC3,CEBPD,DGAT1,FASN,FLNC,IFI44,ITGB3,PLIN2,POLI,PTPRK,RRM2 17 (9) 8 ATF2 Na+,K+ -ATPase ANGPT4 growth factor -0.000 2 -0.905 5.26E-03 1.51E-02 Akt,ANGPT4,ERK1/2,NOS3 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,SOD3,TNFSF14 11 (4) 3 deferoxamine MFAP5 TIE1 omacetaxine mepesuccinate chemical drug 2 0.302 5.26E-03 1.80E-02 Akt,Jnk,MAPK14,omacetaxine mepesuccinate AIMP2,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,L1CAM,LRP6,RRM2,TNFSF14 11 (4) 3 CASP3 SAA1 transporter 2 -0.229 5.28E-03 4.35E-02 Akt,ERK1/2,Jnk,NFkB (complex),NFKBIA,P38 MAPK,SAA1,SOAT1 AIMP2,ALDH7A1,ANGPT2,ANK1,AOC1,B4GALT1,CD209,CEBPD,CLEC10A,FASN,ITGB3,KRT8,L1CAM,LITAF,NCAN,PLG,RRM2,SOD3,TNFSF14 19 (8) 7 ADAM10,camptothecin,CNTF beta-naphthoflavone,MAP3K7,NR5A2,SCD Ca2+,CCL3L3,CXCL10,S100A9 CYP19,phospholipid PDCD6 other 0.000 2 -1.291 5.31E-03 2.96E-02 CDKN1A,cisplatin,Jnk,PDCD6 ADRM1,ANK1,BIRC2,CD209,CLEC10A,GLB1,GSTM3,ITGB3,L1CAM,LRP6,MEGF10,MEGF6,PLG,RRM2,SUSD2 15 (4) 3 benzo(a)pyrene caspase TMSB4 group 2 -1.886 5.34E-03 3.78E-02 ERK,FOS,Jnk,JUN,MAPK1,MAPK3,MAPK8,P38 MAPK,PTK2,TMSB4 ADGRG6,ANK1,B4GALT1,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FASN,FLNC,HSD3B2,IFI44,ITGB3,KRT8,NUBP1,PLG,POLI,PTPRK 18 (10) 9 indomethacin DSPP CASP3 SOD3 enzyme 1.414 2 Activated 2.000 5.39E-03 2.95E-02 Creb,CTNNB1,Jnk,P38 MAPK,SOD3 ACAA1,ANK1,BIRC3,CD209,CEBPD,CLEC10A,DPY19L3,EMX2,ITGB3,KIFC1,L1CAM,PGK1,PLG,PLIN2,RRM2,SUSD2 16 (5) 4 ATOX1,ATP2B2,ATP7A,benzo(a)pyrene,DETA-NONOate,NFkB (complex) CTSA,paraquat,prednisolone,vanoxerine RPSA translation regulator 0.000 2 1.213 5.39E-03 3.89E-02 ERK,ERK1/2,Jnk,JUN,MAPK14,MAPK8,NFKBIA,P38 MAPK,RPSA ADGRG6,ANGPT2,ANK1,AOC1,B4GALT1,CD209,CEBPD,CLEC10A,DGAT1,FASN,ITGB3,KRT8,LITAF,LRP6,NCAN,POLI,SOD3 17 (9) 8 FASLG CASP3,DUSP2,TAP1,TRAF1 GLRX2 enzyme 2 Inhibited -2.121 5.39E-03 9.20E-03 AKT1,Ap1,GLRX2 BIRC3,CALM1 (includes others),CEBPD,FASN,HNRNPM,MATR3,PLG,RRM2 8 (3) 2 AKT1 IFT20 other -0.000 2 1.508 5.40E-03 1.87E-02 Akt,ERK1/2,Focal adhesion kinase,IFT20 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,KRT8,L1CAM,PLG,RRM2,TNFSF14 11 (4) 3 Focal adhesion kinase PDGFRA PRG2 other 2 -1.890 5.42E-03 9.00E-03 AKT1,PRG2,PRKCZ BIRC3,CASP2,CEBPD,FASN,HNRNPM,MATR3,PLG 7 (3) 2 AKT1 papaverine chemical drug 2 -1.604 5.42E-03 2.32E-02 Akt,Creb,ERK,ERK1/2,NOS3,papaverine ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,DPY19L3,ITGB3,L1CAM,PLG,RRM2,SOD3,TNFSF14 14 (6) 5 AGAP2 enzyme 2 -1.606 5.46E-03 4.63E-02 AGAP2,Akt,AKT1,ERK,Focal adhesion kinase,MTOR,NCL,NFkB (complex),PI3K (complex),PRKCZ ADGRG6,AIMP2,ALDH7A1,ANGPT2,B4GALT1,BIRC2,BIRC3,CASP2,CEBPD,FASN,HNRNPM,ITGB3,KRT8,L1CAM,MATR3,PLG,RRM2,SOD3,TNFSF14 19 (10) 9 Focal adhesion kinase,NFkB (complex) MERTK kinase 2 -1.147 5.46E-03 4.58E-02 Akt,ERK1/2,MAPK8,MERTK,P38 MAPK,PTPN11,SRC (family),STAT3,TLR3 ABCA3,AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,DGAT1,FASN,ITGB3,L1CAM,PGK1,PLG,PPP1CA,RRM2,TNFSF14 19 (9) 8 BHLHE40,etoposide,GW3965,PPARD,PROS1 GRN,MRX-2843 IFNB1 MFN2 enzyme 0.000 2 1.291 5.47E-03 3.06E-02 ATF6,EIF2AK3,ERK1/2,Jnk,MAPK1,MFN2,RAF1 ANGPT2,AOC1,BIRC2,BIRC3,CD209,CLEC10A,FLNC,IFI44,ITGB3,PLG,PLIN2,PNLIP,PTPRK,RRM2,SLC16A7 15 (7) 6 teriflunomide,TRIB1 1-methyl-4-phenylpyridinium,deferoxamine,indomethacin CX3CL1 PPP1R15A NRG2 growth factor -0.000 2 0.471 5.48E-03 4.20E-02 Akt,ERBB2,ERBB3,ERBB4,ERK1/2,NRG2,RB1 AIMP2,AOC1,BIRC2,BIRC3,CALCRL,CELSR1,DPY19L3,FASN,H2BC21,ITGB3,L1CAM,MAPK4,PGK1,PLG,POLI,PTPRK,TNFSF14,TNXB 18 (7) 6 PEA15 transporter 2 0.577 5.50E-03 2.57E-02 ERK1/2,Jnk,MAPK14,MAPK8,P38 MAPK,PEA15 ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,CD209,CEBPD,CLEC10A,DGAT1,FASN,LRP6,PLG 12 (6) 5 AKT1,lactacystin ADAM10,IgG,KN 93 PLD1 CASP3,caspase,LHB TP53BP2 other -0.000 2 0.000 5.53E-03 4.47E-02 CTNNB1,NFkB (complex),RAF1,TAFAZZIN,TP53BP2 ACAA1,ADRM1,ALDH7A1,B4GALT1,BIRC2,BIRC3,CEBPD,EMX2,FASN,ITGB3,KIFC1,L1CAM,PGK1,PLIN2,RRM2,SLC16A7,SOD3,SUSD2 18 (5) 4 POU5F1 NFkB (complex) CDK2AP1 other 2 Activated 2.309 5.57E-03 2.79E-02 CDK2,CDK2AP1,PGR,RB1 ANGPT2,BIRC2,BIRC3,CALCRL,CEBPD,CELSR1,GSTM3,H2BC21,IFI44,MAPK4,RRM2,SNAP25 12 (4) 3 PGR PMP22 other 0.000 2 0.000 5.59E-03 1.91E-02 Akt,ERK,PMP22 ADGRG6,AIMP2,BIRC2,CEBPD,ITGB3,L1CAM,P2rx7,PLG,RRM2,TNFSF14 10 (3) 3 DGCR8 mir-154,onapristone,RXRA,WNT3A Ca2+ KLKB1 peptidase -0.000 2 -1.807 5.64E-03 3.05E-02 Akt,ERK1/2,HGF,KLKB1,p70 S6k,PLAU AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CALCRL,CALM1 (includes others),CASP2,CELSR1,FASN,ITGB3,LGMN,PLG,RRM2,TNFSF14 15 (6) 5 PRCP BDKRB2 MAS1 noscapine chemical drug 1 1.414 5.66E-03 4.60E-03 noscapine BIRC2,BIRC3 2 (1) 1 NFkB (complex),TRAF1 FOXO4 transcription regulator 2 -0.471 5.78E-03 4.87E-02 26s Proteasome,Akt,CDK2,CDKN1A,FOXO4,HIF1A,SIRT1 ADRM1,AIMP2,CLEC10A,FASN,GLB1,HCRTR2,IFI44,ITGB3,L1CAM,PGK1,PLG,RRM2,SLC16A4,SNAP25,SOD3,TMPRSS6,TNFSF14,TSG101 18 (7) 7 AKT1,FGF4,INS,PDGFB ANGPT1,FASLG,GABARAPL1,SCD CCND2,CDH5,LCP2,NRP2,PRCP,TIE1 nitazoxanide chemical drug 2 0.816 5.84E-03 9.50E-03 EIF4EBP1,nitazoxanide,NQO1,p70 S6k,POR BIRC2,BIRC3,CEBPD,FASN,FGL1,SUSD2 6 (5) 4 POR lithocholic acid chemical - endogenous mammalian 2 -0.832 5.84E-03 2.59E-02 Akt,lithocholic acid,NR1I2,VDR AIMP2,ANGPT2,BIRC2,CUBN,CYP39A1,GSTM3,HSD3B2,L1CAM,PLG,PLIN2,PPP1CA,RRM2,TNFSF14 13 (4) 3 Ca2+,CAMP,tauroursodeoxycholic acid GRN CHCHD2 other 2 -0.577 5.84E-03 2.28E-02 Akt,CHCHD2,Jnk,SMAD3 AIMP2,BIRC2,BIRC3,CD209,CLEC10A,DGAT1,FASN,L1CAM,PLG,PTPRK,RRM2,TNFSF14 12 (4) 3 L-2286 chemical reagent 2 -1.732 5.84E-03 2.40E-02 Akt,ERK1/2,Jnk,L-2286,P38 MAPK AIMP2,ANGPT2,ANK1,AOC1,BIRC2,CD209,CEBPD,CLEC10A,ITGB3,L1CAM,RRM2,TNFSF14 12 (5) 4 CHRNA4 transmembrane receptor 0.000 2 -1.069 5.85E-03 2.71E-02 Akt,CHRNA4,MAPK1,MAPK3,MAPK8,MAPT AIMP2,ASPG,B4GALT1,BIRC2,BIRC3,DGAT1,FLNC,IFI44,ITGB3,L1CAM,PLG,PTPRK,RRM2,TNFSF14 14 (6) 5 acetylcholine,arecoline,galanthamine,NRG (family) Li+ chemical reagent 2 0.832 5.91E-03 3.19E-02 AKT1,CTNNB1,GSK3B,Li+,SLC6A4 ACAA1,BIRC2,CEBPD,EMX2,GNAO1,HNRNPM,KIFC1,L1CAM,MATR3,PGK1,PLG,PLIN2,SUSD2 13 (5) 4 AKT1 CASP3 ATP2B2 transporter 0.000 1 1.732 5.91E-03 1.17E-02 ATP2B2 FLNC,RAB11A,SOD3 3 (1) 1 nifedipine HIPK2,SOD3 Ca2+,KIT,RPL22 TRPC6 ion channel -0.000 2 -1.155 5.99E-03 2.57E-02 Akt,AKT1,ERK,Nfat (family),TRPC6 ADGRG6,AIMP2,B4GALT1,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,ITGB3,L1CAM,MATR3,RRM2 12 (5) 4 Notch,tunicamycin NFkB (complex),sildenafil,teriflunomide AKT1 O6-benzylguanine chemical drug 2 1.414 6.00E-03 1.52E-02 AKT1,AMPK,CDK2,CHEK1,O6-benzylguanine BIRC3,CEBPD,FASN,HNRNPM,MATR3,PLG,RRM2,SNAP25 8 (5) 4 AKT1 JMJD8 other -0.000 2 1.732 6.06E-03 2.71E-02 AKT1,CTNNB1,JMJD8 ACAA1,BIRC3,CEBPD,EMX2,HNRNPM,KIFC1,L1CAM,MATR3,PGK1,PLG,PLIN2,SUSD2 12 (3) 2 AKT1 WNT16 other 2 -1.732 6.06E-03 2.75E-02 AKT1,CTNNB1,WNT16 ACAA1,BIRC3,CEBPD,EMX2,HNRNPM,KIFC1,L1CAM,MATR3,PGK1,PLG,PLIN2,SUSD2 12 (3) 2 8-bromo-cAMP,DSCAM ACADS,AKT1 Frizzled ibutamoren chemical drug 2 Inhibited -2.111 6.09E-03 1.45E-02 AKT1,ERK1/2,ibutamoren,YAP1 ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,ITGB3,MATR3,PLG,RRM2 11 (4) 3 AKT1 KIR2DS2 (includes others) transmembrane receptor 2 -1.265 6.09E-03 1.57E-02 ERK,ERK1/2,Jnk,KIR2DS2 (includes others) ADGRG6,ANGPT2,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 10 (4) 3 Hsp90 POU2AF1 transcription regulator 2 1.414 6.11E-03 1.21E-02 ERK1/2,POU2AF1,POU2F1 ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,H2BC21,IFI44,ITGB3 8 (3) 3 Pam3-Cys,peptidoglycan,PPP3CA IgG Ca2+ SOSTDC1 growth factor 2 -1.155 6.14E-03 2.19E-02 Akt,ERK1/2,Jnk,SOSTDC1,SRC (family) AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CD209,CLEC10A,ITGB3,L1CAM,PLG,RRM2,TNFSF14 12 (5) 4 BMP7 FGF4 PIP5K1B kinase 2 1.508 6.17E-03 1.97E-02 Akt,ERK,Jnk,PIP5K1B ADGRG6,AIMP2,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,L1CAM,RRM2,TNFSF14 11 (4) 3 deferoxamine,Dishevelled,PGR,sucrose Sapk RGS16 enzyme 2 0.000 6.29E-03 4.88E-02 Akt,ERK1/2,GNAS,MAPK1,MAPK3,P38 MAPK,RGS16 AIMP2,ANGPT2,ANK1,AOC1,B4GALT1,BIRC3,CEBPD,FASN,FLNC,IFI44,L1CAM,LITAF,PLG,PTPRK,RRM2,TNFSF14 16 (7) 6 ammonium,BHLHE40,L-triiodothyronine ACADS enzyme 0.000 2 0.333 6.34E-03 1.99E-02 ACADS,Akt,AMPK,PRKCE AIMP2,BIRC2,BIRC3,CHRNB3,FASN,L1CAM,PLG,RRM2,TNFSF14 9 (4) 3 PPARA,TFAM,WNT16,WNT3A CIDEC,MAP4K4,SOST FGF19 growth factor 2 -1.000 6.35E-03 3.55E-02 ERK,ERK1/2,FGF19,FGFR2,FGFR4,JINK1/2,PRKCZ,STAT3 ADGRG6,ANGPT2,AOC1,BIRC2,BIRC3,CASP2,CD209,CEBPD,CUBN,DGAT1,FASN,ITGB3,PGK1,PLG,RRM2,TENM3 16 (8) 8 ESR2,NR5A2 FGFR3,FGFR4,JINK1/2 SCD IRAK3 kinase 2 0.243 6.36E-03 4.14E-02 ERK1/2,IRAK3,Jnk,MAPK1,MAPK3,MAPK8,NFKBIA,P38 MAPK ANGPT2,ANK1,AOC1,B4GALT1,CD209,CEBPD,CLEC10A,DGAT1,FLNC,IFI44,ITGB3,KRT8,LITAF,NCAN,PLG,PTPRK,SOD3 17 (8) 7 zoledronic acid IFNB1,NFkB (complex) Ybx1-ps3 other 2 0.943 6.36E-03 4.89E-02 Akt,ERK1/2,IL6ST,INSR,STAT3,Ybx1-ps3 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CD209,CEBPD,CGAS,DGAT1,FCGBP,HSD3B2,ITGB3,L1CAM,PGK1,PLG,RRM2,SLC5A7,TNFSF14 18 (6) 5 CAB39L kinase 2 -0.535 6.37E-03 4.07E-02 CAB39L,PPARGC1A,PRKAA,PRKAA1,STK11 BIRC3,CEBPD,DGAT1,DUT,EMILIN2,FASN,H2BC21,IFI44,LITAF,PGK1,PLIN2,RRM2,SLC16A4,SVEP1 14 (5) 4 PRKAA1 FZD4 G-protein coupled receptor -0.000 2 -0.832 6.39E-03 2.67E-02 CTNNB1,FZD4,Jnk,Pkc(s) ACAA1,BIRC3,CD209,CLEC10A,EMX2,FASN,KIFC1,KRT8,L1CAM,PGK1,PLG,PLIN2,SUSD2 13 (4) 3 N-acetylmuramyl-L-alanyl-D-isoglutamine FANCC,mir-154,MIR17-92,MIR17HG,WNT3A racemic flurbiprofen chemical drug 2 0.277 6.39E-03 3.73E-02 CTNNB1,ERK,Gsk3,PTGS1,PTGS2,racemic flurbiprofen ACAA1,ADGRG6,ANGPT2,BIRC3,CEBPD,EMX2,FASN,ITGB3,KIFC1,L1CAM,PGK1,PLIN2,SUSD2 13 (6) 5 Ca2+ prostaglandin E2 CLCF1 cytokine 2 -1.000 6.41E-03 3.78E-02 CLCF1,ERK1/2,IL6ST,JAK,Jnk,P38 MAPK,STAT,STAT1,STAT3 ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CASP2,CD209,CEBPD,CGAS,CLEC10A,FASN,ITGB3,PGK1,PLG,RRM2,SLC5A7 16 (9) 8 NFkB (complex) IgG,SOCS3 TFPI other 0.000 2 0.500 6.41E-03 4.03E-02 Ap1,Ca2+,F2,F5,MMP2,MMP9,NFkB (complex),TFPI ALDH7A1,ANGPT2,B4GALT1,BIRC2,BIRC3,CALM1 (includes others),CASP2,CEBPD,FASN,KRT8,L1CAM,MMRN1,PLG,RRM2,SOD3,TSG101 16 (8) 7 MFAP5,phytohemagglutinin MMP7,SAA Ca2+,F10,F5,NFkB (complex),phospholipid CBLC enzyme 2 1.698 6.42E-03 4.67E-02 Akt,CBLC,EGFR,EIF2AK3,ERK,ERK1/2,NGFR,SRC ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,ITGB3,L1CAM,PGK1,PLG,PNLIP,RRM2,SNAP25,TNFSF14,TNXB 17 (8) 7 EBF1 HMOX1,NOX4 MAPK8IP2 other 2 -1.069 6.43E-03 3.21E-02 APP,MAPK8,MAPK8IP2,MAPK9,P38 MAPK ANK1,B4GALT1,BIRC3,CEBPD,DGAT1,FASN,GSTM3,ITGB3,LRP6,PLIN2,POU3F3,SOD3,THSD4,TPPP3 14 (5) 4 MAGI3 kinase 0.000 2 -1.897 6.45E-03 1.71E-02 AKT1,ERK,Jnk,MAGI3 ADGRG6,BIRC3,CD209,CEBPD,CLEC10A,FASN,HNRNPM,ITGB3,MATR3,PLG 10 (4) 3 AKT1 ITGB1BP1 other -0.000 2 -0.277 6.46E-03 3.16E-02 Akt,ERK1/2,ITGB1,ITGB1BP1,NOTCH1 AIMP2,ANGPT2,AOC1,ITGB3,KRT8,L1CAM,LRP6,PGK1,PLG,PTPRK,RRM2,TNFSF14,TNXB 13 (5) 4 PDGF-AA complex 2 Inhibited -2.500 6.47E-03 3.45E-02 Akt,AKT1,CEACAM1,ERK1/2,Mek,PDGF-AA,PI3K (complex),PRKCD,RAS AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CASP2,CEBPD,FASN,HNRNPM,ITGB3,L1CAM,MATR3,PLG,RRM2,TNFSF14 16 (9) 8 AKT1,FGF7,PDGFRA chelidonine chemical - endogenous non-mammalian 2 0.000 6.47E-03 4.06E-02 Akt,chelidonine,ERK1/2,Mek,NRAS,RB1 AIMP2,AOC1,BIRC2,BIRC3,CALCRL,CASP2,CELSR1,FASN,H2BC21,ITGB3,L1CAM,MAPK4,PLG,TNFSF14,TULP4,VPS25 16 (6) 5 CASP3 1'-acetoxychavicol acetate chemical reagent 1 1.414 6.50E-03 6.60E-03 1'-acetoxychavicol acetate BIRC2,BIRC3 2 (1) 1 JINK1/2,NFkB (complex) EHHADH enzyme 0.000 1 0.000 6.50E-03 1.26E-02 EHHADH ACAA1,FASN 2 (1) 1 4-phenylbutyric acid,ACSS2,RXRA,VEGFB L-triiodothyronine fatty acid ACSL1,SCP2 FASTK kinase 2 0.000 6.50E-03 8.90E-03 FASTK,TIA1 BIRC2,CALM1 (includes others) 2 (2) 2 MAS1 G-protein coupled receptor 1 0.000 6.50E-03 7.10E-03 MAS1 CLEC10A,FASN 2 (1) 1 telmisartan KLKB1 Ca2+ CD2AP other 2 -1.387 6.54E-03 3.41E-02 Akt,AKT1,CD2AP,ERK1/2,P38 MAPK AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,FASN,HNRNPM,L1CAM,MATR3,PLG,RRM2,TNFSF14 13 (5) 4 [D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin AKT1,NPHS1 CASP3 Slfn1 enzyme 2 1.604 6.57E-03 3.19E-02 Akt,ERK1/2,RB1,Slfn1 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CALCRL,CELSR1,H2BC21,ITGB3,L1CAM,MAPK4,PLG,RRM2,TNFSF14 14 (4) 3 PDGFRA PDGFD growth factor 2 -1.500 6.59E-03 3.25E-02 Akt,ERK,MAPK8,PDGFD,STAT3 ADGRG6,AIMP2,ANGPT2,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,DGAT1,FASN,ITGB3,L1CAM,PGK1,PLG,RRM2,TNFSF14 16 (5) 4 8-bromo-cAMP,carbon tetrachloride Srebp group 3 0.728 6.60E-03 3.82E-02 Akt,ERK,NR5A2,PPARG,SREBF1,SREBF2,Srebp,YAP1 ACAA1,ADGRG6,AIMP2,BIRC2,DGAT1,DPY19L3,FASN,GLB1,HSD3B2,ITGB3,L1CAM,PLG,PLIN2,PNLIP,REG1A,RRM2,TNFSF14 17 (8) 8 Map3k7,xanthohumol ACSL1,ACSS2 LRRFIP1 transcription regulator 2 -1.000 6.65E-03 4.15E-02 CTNNB1,ERK,LRRFIP1,NFkB (complex) ACAA1,ADGRG6,ALDH7A1,B4GALT1,BIRC2,BIRC3,CEBPD,EMX2,FASN,ITGB3,KIFC1,L1CAM,PGK1,PLIN2,SOD3,SUSD2 16 (4) 3 ammonium IFNB1,NFkB (complex) POU5F1 transcription regulator 2 Inhibited -2.309 6.67E-03 2.99E-02 AKT1,ATM,ETS2,POU5F1,SNAI2 BIRC2,BIRC3,CASP2,CEBPD,FASN,GLB1,HNRNPM,L1CAM,MATR3,MKX,PLG,RRM2 12 (5) 5 CCNE1,EPAS1,etoposide,L-triiodothyronine,mitomycin C,Notch,NR5A2,PCGF1,PIK3CA,RXRA,TERT,TNFRSF11A,WNT3A CDKN2A,miR-34a-5p (and other miRNAs w/seed GGCAGUG) ANGPT1,CDH2,FRZB,GPI,IRS1,NR0B1,PDGFRA,SOCS3,TNFSF4,TP53BP2,USP18,WNT5A,YES1 CASP3,CD63,CIDEB,CTSA,CXCL10,CXCL9,PPARA ZFTA-RELA fusion gene/product 1 -1.732 6.68E-03 1.36E-02 ZFTA-RELA BIRC3,L1CAM,LITAF 3 (1) 1 CCL3L3,CX3CL1,CXCL10,DUSP2,PDGFB,SDC4,TAP1 nirogacestat chemical drug 2 Activated 2.111 6.75E-03 2.20E-02 Akt,ERK,nirogacestat,PI3K (family) ADGRG6,AIMP2,BIRC2,BIRC3,CEBPD,FASN,ITGB3,L1CAM,PLG,RRM2,TNFSF14 11 (4) 3 Secretase gamma TRIB2 kinase -0.000 2 1.155 6.75E-03 2.57E-02 AKT1,CEBPA,TRIB2 ABCA3,BIRC3,CEBPD,EMX2,FASN,HNRNPM,KRT8,LITAF,MATR3,MMRN1,PLG,PLIN2 12 (3) 3 CASP3 AKT1 MARVELD3 other 2 1.134 6.77E-03 1.21E-02 Ap1,Jnk,MAP3K1,MARVELD3 BIRC2,BIRC3,CALM1 (includes others),CD209,CLEC10A,PLG,RRM2 7 (4) 3 BMS-536924 chemical drug 2 1.000 6.78E-03 3.98E-02 Akt,BMS-536924,ERK,ERK1/2,IGF1R,INSR ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,DGAT1,FASN,FCGBP,HSD3B2,ITGB3,L1CAM,PLG,RRM2,TNFSF14 16 (6) 5 CHKA kinase 2 -0.535 6.78E-03 3.41E-02 Akt,CHKA,choline,ERK,MAPK1,MAPK3 ADGRG6,AIMP2,B4GALT1,BIRC2,CEBPD,FLNC,IFI44,ITGB3,L1CAM,PLG,PTPRK,RRM2,SLC5A7,TNFSF14 14 (6) 5 Pi3k class I choline,sphingomyelin MME peptidase -0.000 2 0.632 6.82E-03 1.94E-02 AKT1,Focal adhesion kinase,IGF1R,MME,SRC BIRC3,CEBPD,FASN,HNRNPM,HSD3B2,KRT8,MATR3,PGK1,PLG,RRM2 10 (5) 4 EP300,ESR2,etoposide,Secretase gamma,TMPRSS2-ERG,TNFRSF11A AKT1,Focal adhesion kinase SYVN1 transporter -0.000 1 -1.342 6.84E-03 1.51E-02 SYVN1 CALM1 (includes others),FASN,HNRNPM,IFI44,L1CAM 5 (1) 1 tunicamycin BHLHE40,CALM1 (includes others),DAB2,DIO2,HSPB1,LGALS3BP,SLC2A1,SLC3A2,VAMP7 TRA fumonisin B1 chemical toxicant 2 1.069 6.85E-03 3.17E-02 Akt,fumonisin B1,JUN,KDR,MAPK8,P38 MAPK AIMP2,ANGPT2,ANK1,B4GALT1,BIRC2,BIRC3,CEBPD,DGAT1,ITGB3,L1CAM,PLG,POLI,RRM2,TNFSF14 14 (6) 5 CASP3,ceramide,sphingomyelin fatty acid chemical - endogenous mammalian 1 1.000 6.89E-03 8.40E-03 fatty acid AOC1,DGAT1,FASN,PLIN2 4 (1) 1 ACSL1,CIDEB,CIDEC,CRBN,D-fructose,EHHADH,ellagic acid,FGF7,L-triiodothyronine,oleic acid,RETN,SOST CAV3,INS,KDM3A,quercetin,RGS4,SCP2,sildenafil,SLC30A7 CASP3,ceramide,FFAR1,FFAR4,GPAM,HMOX1,HSPB1,JINK1/2,LHB,NFkB (complex),PAK2,SLC2A1,SOCS3 AKT1 PPP3R1 phosphatase -0.000 2 -1.134 6.90E-03 1.42E-02 Calcineurin protein(s),MAP3K7,Map3k7,PPP3CA,PPP3R1,TAB1 ABCA3,ABCA5,BIRC3,FASN,IFI44,KRT8,TSG101 7 (6) 6 MAPK7 RGS4,tacrolimus CCND2,PPARA,PPP3CA,SCD,USP2 CDH17,DNM1,Map3k7,MAP3K7,TNFRSF11A l-asparaginase biologic drug 2 -1.155 6.91E-03 2.51E-02 Akt,ERK1/2,l-asparaginase AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,FASN,ITGB3,KIFC1,L1CAM,PLG,RRM2,TNFSF14 12 (3) 3 iron BTG2,KIF22,UBE2C serpin peptide 16 biologic drug 2 -1.508 6.92E-03 2.12E-02 Akt,ERK1/2,LRP1,serpin peptide 16 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,PLIN2,RRM2,TNFSF14 11 (4) 3 ARR3 other 2 -0.333 6.95E-03 1.46E-02 ARR3,Jnk,MAPK14,MAPK8 B4GALT1,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FASN,LRP6,PLG 9 (4) 3 phytohemagglutinin,RABGEF1 CASP3 SIAH1 enzyme 2 0.775 6.96E-03 3.58E-02 APC,CTNNB1,Jnk,MYB,NUMB,PKD1,SIAH1 ACAA1,BIRC3,CD209,CLEC10A,EMX2,ITGB3,KIFC1,L1CAM,MEGF10,PGK1,PLG,PLIN2,SLC16A4,SUSD2,TULP4 15 (7) 6 camptothecin,lactacystin GRM5 LN730 chemical reagent 2 0.832 6.98E-03 3.20E-02 Akt,Jnk,LN730,MAPK1 AIMP2,BIRC2,BIRC3,CD209,CLEC10A,FLNC,IFI44,ITGB3,L1CAM,PLG,PTPRK,RRM2,TNFSF14 13 (4) 3 PLCL1 enzyme 0.000 2 -1.508 7.01E-03 2.24E-02 Akt,AKT1,LIPE,PLCL1 AIMP2,BIRC2,BIRC3,CEBPD,HNRNPM,L1CAM,MATR3,PLG,PLIN2,RRM2,TNFSF14 11 (4) 3 AKT1,Ca2+ DIO2,PPARA,PPARD MDL 73811 chemical reagent 2 0.707 7.01E-03 2.34E-02 MDL 73811,RB1 ANGPT2,CALCRL,CELSR1,GLB1,H2BC21,ITGB3,MAPK4,RRM2 8 (2) 2 LGALS3BP ASIP other 3 0.500 7.04E-03 4.73E-02 Akt,ASIP,Creb,ERK,ERK1/2,MAPK1,MAPK3,MC1R,MC4R ADGRG6,AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,DPY19L3,FASN,FLNC,IFI44,L1CAM,PLG,PTPRK,RRM2,TNFSF14 16 (9) 7 Ca2+,HTR1B,NPY PD158780 chemical drug 2 0.943 7.05E-03 4.85E-02 Akt,EGFR,ERK,ERK1/2,MAPK1,PD158780,SRC ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,FLNC,IFI44,ITGB3,L1CAM,PGK1,PLG,PTPRK,RRM2,TNFSF14,TNXB 18 (7) 6 L-cysteine chemical - endogenous mammalian 2 0.000 7.10E-03 4.48E-02 Akt,IRS1,L-cysteine,LIPE,MAPK8,PTEN ACAA1,AIMP2,ANGPT2,B4GALT1,BIRC2,BIRC3,CALCRL,CEBPD,CELSR1,DGAT1,L1CAM,PGK1,PLG,PLIN2,RRM2,TNFSF14 16 (6) 5 IRS1,NMDA Receptor,RPS6KB1,SCD Ca2+,PLCB3 aminoxyrone chemical reagent 2 0.632 7.10E-03 2.46E-02 Akt,aminoxyrone,BCL2,STAT5A AIMP2,BIRC2,BIRC3,CASP2,HSD3B2,L1CAM,PLG,RRM2,SNAP25,TNFSF14 10 (4) 3 CRKL BDKRB2 G-protein coupled receptor 2 -1.213 7.15E-03 4.84E-02 AKT1,BDKRB2,CNR1,EGFR,ERK1/2,JINK1/2,MAPK1,MAPK3,MAPT,MMP2,NOS3 ANGPT2,AOC1,ASPG,B4GALT1,BIRC2,BIRC3,CEBPD,FLNC,HNRNPM,IFI44,ITGB3,LRP4,MATR3,PLG,PTPRK,SOD3,TNXB 17 (11) 10 EP300,GRK2,KLKB1 IRX1 AKT1,Ca2+,G protein,JINK1/2 urea SERPIND1 other 2 0.000 7.16E-03 3.78E-02 F2,NOS3,PRKAA,PRKAA2,SERPIND1,STK11 ANGPT2,B4GALT1,BIRC2,BIRC3,CASP2,DUT,FASN,IFI44,PGK1,RRM2,SLC16A4,SOD3 12 (6) 5 NTN1 growth factor 0.000 2 -0.832 7.22E-03 2.97E-02 Creb,DSCAM,ERK1/2,Jnk,NTN1 ANGPT2,AOC1,BIRC2,BIRC3,CD209,CLEC10A,DPY19L3,ITGB3,L1CAM,NLGN2,PLG,RRM2,SYT12 13 (5) 4 DSCAM,PLC gamma,RAPGEF3 CASP3,leukotriene B4,prostaglandin E2 delta-tocotrienol chemical drug 2 -0.243 7.27E-03 4.97E-02 Akt,delta-tocotrienol,P38 MAPK,PPARA,PPARD,PPARG,SREBF2 ACAA1,AIMP2,ANGPTL3,ANK1,BIRC2,CYP39A1,DGAT1,FCGBP,GSTM3,ITGB3,L1CAM,PLG,PLIN2,REG1A,RRM2,SERINC2,TNFSF14 17 (7) 6 PPARA,PPARD Pdpk ICI 118,551 chemical reagent 2 -1.508 7.28E-03 2.83E-02 ATP2A2,ERK,ERK1/2,ICI 118,551,IGF1R,MAPK3 ADGRG6,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,FASN,HSD3B2,ITGB3,RRM2 11 (6) 5 GNAI3 TFAP2B transcription regulator 0.000 2 0.832 7.30E-03 3.83E-02 Akt,INSR,IRS1,MMP2,TERT,TFAP2B AIMP2,BIRC2,CEBPD,DGAT1,FASN,FCGBP,GLB1,HSD3B2,IFI44,L1CAM,PLG,RRM2,TNFSF14 13 (6) 5 TNFRSF11A EPAS1,KIT,TERT IRS1 avexitide biologic drug 2 0.277 7.30E-03 3.68E-02 Akt,avexitide,MAPK1,MAPK3,p70 S6k,PI3K (complex) AIMP2,B4GALT1,BIRC2,BIRC3,FASN,FLNC,IFI44,ITGB3,L1CAM,PLG,PTPRK,RRM2,TNFSF14 13 (6) 5 NOX4 CD63 other 0.000 2 0.000 7.33E-03 3.38E-02 Akt,CD63,ERK,ERK1/2,KDR,PTK2,SRC ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,L1CAM,PGK1,PLG,RRM2,TNFSF14 12 (7) 6 IL27,POU5F1,PPARA,quercetin,SRT2104 PLC gamma CAV3 enzyme 0.000 2 0.000 7.37E-03 4.91E-02 Akt,AKT1,CAV3,ERK1/2,INSR,IRS1,TGFBR1 AIMP2,ANGPT2,AOC1,CEBPD,DGAT1,FASN,FCGBP,HNRNPM,HSD3B2,ITGB3,L1CAM,MATR3,PLG,PTPRK,RRM2,TNFSF14 16 (7) 6 EP300,lactacystin,NFkB (complex),PPP3CA,RPS6KB1 ammonium,MSTN,tacrolimus AKT1,IRS1 fatty acid HTR1B G-protein coupled receptor 0.000 2 Inhibited -2.496 7.38E-03 3.34E-02 Akt,ERK,FOS,HTR1B ADGRG6,AIMP2,BIRC2,CEBPD,FASN,HSD3B2,ITGB3,KRT8,L1CAM,NUBP1,PLG,RRM2,TNFSF14 13 (4) 3 ASIP PLD1 liraglutide biologic drug 2 -1.941 7.38E-03 2.97E-02 Akt,AKT1,ERK1/2,liraglutide AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,HNRNPM,ITGB3,L1CAM,MATR3,PLG,RRM2,TNFSF14 13 (4) 3 AKT1,FGFR3 lonafarnib chemical drug 1 1.414 7.39E-03 6.40E-03 lonafarnib BIRC2,BIRC3 2 (1) 1 CASP3,RPS6KB1 NFkB (complex),TRAF1 MAP3K4 kinase 0.000 2 -1.387 7.46E-03 3.37E-02 ERK,Jnk,MAP2K4,MAP3K4,MAPK14,MAPK8,MAPK9,MAPKAPK2,P38 MAPK ADGRG6,ANK1,B4GALT1,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,ITGB3,LRP6,PLG,PLIN2,SOD3 13 (9) 8 MAP2K4/7,Sapk CALML6 other 2 0.577 7.50E-03 2.84E-02 CALML6,Jnk,MAP3K7,NFKBIA,P38 MAPK ANK1,BIRC2,CD209,CEBPD,CLEC10A,IFI44,ITGB3,KRT8,LITAF,NCAN,PLG,SOD3 12 (5) 4 MAP3K7 LRP8 transmembrane receptor 2 -1.414 7.50E-03 1.77E-02 AKT1,LRP8,MAPT,SRC (family) ASPG,BIRC3,CEBPD,FASN,HNRNPM,ITGB3,MATR3,PLG 8 (4) 3 AKT1,NMDA Receptor R59949 chemical drug 2 1.732 7.59E-03 2.88E-02 AKT1,Hif,HIF1A,R59949 BIRC2,BIRC3,CEBPD,FASN,HNRNPM,ITGB3,L1CAM,MATR3,PGK1,PLG,SLC16A4,TMPRSS6 12 (4) 3 1,2-dioctanoyl-sn-glycerol,AKT1,Dgk Evans Blue chemical toxicant 2 0.000 7.72E-03 4.80E-02 Akt,Evans Blue,IGF1R,INSR,IRS1,IRS2,MAPK1,MAPK3 AIMP2,B4GALT1,BIRC2,CEBPD,DGAT1,FASN,FCGBP,FLNC,HSD3B2,IFI44,ITGB3,L1CAM,PLG,PTPRK,RRM2,TNFSF14 16 (8) 7 IRS1 LGALS3BP transmembrane receptor 0.000 2 -1.667 7.72E-03 1.86E-02 Akt,KDR,LGALS3BP,PI3K (family) AIMP2,ANGPT2,BIRC2,BIRC3,FASN,L1CAM,PLG,RRM2,TNFSF14 9 (4) 3 BHLHE40,CX3CL1,eflornithine,MDL 73811,SYVN1 ESR2,miR-34a-5p (and other miRNAs w/seed GGCAGUG) FGF9 growth factor 2 -0.728 7.74E-03 4.33E-02 Akt,ERK1/2,FGF9,FGFR2,MAPK1,MAPK3,MTOR AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CUBN,FASN,FLNC,IFI44,ITGB3,L1CAM,PLG,PTPRK,RRM2,TENM3,TNFSF14 17 (7) 6 8-bromo-cAMP,benzo(a)pyrene,PRNP CNTF FGF7,HMOX1,RPS6KB1 CD74-NRG1 fusion gene/product 2 -0.535 7.75E-03 4.01E-02 Akt,CD74-NRG1,ERBB2,ERBB3,p70 S6k AIMP2,ANGPT2,BIRC2,DPY19L3,FASN,ITGB3,L1CAM,PGK1,PLG,POLI,PTPRK,RRM2,TNFSF14,TNXB 14 (5) 4 risedronic acid chemical drug 3 1.155 7.76E-03 3.05E-02 Akt,ERK,ERK1/2,FDPS,GGPS1,IRS1,risedronic acid ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,FASN,ITGB3,L1CAM,PLG,RRM2,TNFSF14 12 (7) 4 GGPS1 INHA growth factor 2 -1.134 7.89E-03 2.21E-02 FSH,INHA ADAMTS16,Cyp2d22,EMILIN2,FLNC,HSD3B2,KRT8,SNAP25 7 (2) 2 8-bromo-cAMP,forskolin,L-triiodothyronine,NR5A2 thyroid hormone KIT,KRT18,PIK3CD,PIK3IP1 BCAN,CCND2,CCNE1,CNN1,FGFR4,HAS2 resiniferatoxin chemical drug 2 0.775 7.90E-03 3.95E-02 Ap1,ERK,IKK (complex),Jnk,NFkB (complex),resiniferatoxin,STAT1 ADGRG6,ALDH7A1,ANGPT2,B4GALT1,BIRC2,BIRC3,CALM1 (includes others),CASP2,CD209,CEBPD,CLEC10A,ITGB3,PLG,RRM2,SOD3 15 (7) 6 Ca2+ NFkB (complex),NTRK1 2-chloroadenosine chemical reagent 2 1.604 7.91E-03 3.80E-02 2-chloroadenosine,Akt,ERK1/2,RB1 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CALCRL,CELSR1,H2BC21,ITGB3,L1CAM,MAPK4,PLG,RRM2,TNFSF14 14 (4) 3 CASP3 protocatechuic acid NECTIN2 transmembrane receptor 2 0.302 7.94E-03 2.87E-02 Akt,Jnk,NECTIN2,P38 MAPK AIMP2,ANK1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,L1CAM,RRM2,TNFSF14 11 (4) 3 CYP19 group 2 -1.000 7.95E-03 2.21E-02 Akt,CYP19,CYP19A1 AIMP2,ASPG,BIRC2,FASN,L1CAM,PLG,PLIN2,RRM2,TNFSF14 9 (3) 2 prostaglandin E2 SAA1 DISC1 other 2 -0.333 7.95E-03 2.10E-02 ATF4,DISC1,DTNBP1,ERK1/2 ANGPT2,ANGPTL3,AOC1,BIRC2,BIRC3,CHAC1,FASN,ITGB3,SNAP25 9 (4) 3 CALC group 2 -1.604 8.07E-03 3.84E-02 Akt,CALC,CALCA,ERK,ERK1/2,Pkc(s) ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,DGAT1,ITGB3,KRT8,L1CAM,PLG,RRM2,TNFSF14 14 (6) 5 KN 93 VEGFC PHIP other 0.000 2 -0.333 8.07E-03 2.29E-02 Akt,IRS1,MAPK3,PHIP AIMP2,B4GALT1,BIRC2,CEBPD,FASN,L1CAM,PLG,RRM2,TNFSF14 9 (4) 3 CCND2 IRS1 nafamostat chemical drug 3 0.775 8.13E-03 3.52E-02 ERK1/2,GZMK,MAPK1,MAPK14,MAPK3,MAPK8,MAPK9,Mmp,nafamostat,TPSAB1/TPSB2,TPSD1 ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,DGAT1,FLNC,IFI44,ITGB3,LRP6,PLG,PLIN2,PTPRK,SOD3 15 (11) 7 PENK other 2 1.387 8.13E-03 3.56E-02 P38 MAPK,PENK,Pkc(s),PRKCD,PRKCZ,RB1 ANGPT2,ANK1,BIRC2,BIRC3,CALCRL,CASP2,CEBPD,CELSR1,H2BC21,ITGB3,KRT8,MAPK4,RRM2 13 (6) 5 6-hydroxydopamine,ATF3,barium,BMP7,chlorisondamine,forskolin,levothyroxine,prostaglandin E2 CNTF CDKN2A RGMA other 2 1.265 8.13E-03 2.31E-02 Akt,Focal adhesion kinase,PI3K (family),PTK2,RGMA,SRC (family) AIMP2,BIRC2,BIRC3,FASN,ITGB3,KRT8,L1CAM,PLG,RRM2,TNFSF14 10 (6) 5 DSCAM MIR17HG Focal adhesion kinase ATM/ATR group 1 -1.000 8.17E-03 1.08E-02 ATM/ATR RRM2 1 (1) 1 MDM2,RRM2 BC-DXI01 chemical reagent 1 1.000 8.17E-03 1.31E-02 BC-DXI01 AIMP2 1 (1) 1 BI 836845 biologic drug 1 1.000 8.17E-03 1.08E-02 BI 836845 RRM2 1 (1) 1 dATP,RRM2 CAMK2 group 1 -1.000 8.17E-03 1.41E-02 CAMK2 BIRC3 1 (1) 1 Ca2+,Dishevelled,ITPR1,NRG (family) KN 93 CWH43 other 0.000 1 -1.000 8.17E-03 1.17E-02 CWH43 L1CAM 1 (1) 1 DNAJC5 other 0.000 1 -1.000 8.17E-03 1.24E-02 DNAJC5 SNAP25 1 (1) 1 CISH GSTT1 enzyme 1 1.000 8.17E-03 1.20E-02 GSTT1 GSTM3 1 (1) 1 phytohemagglutinin KIF22 other 1 1.000 8.17E-03 1.34E-02 KIF22 MKX 1 (1) 1 CASR l-asparaginase MIR4500 microRNA 1 1.000 8.17E-03 1.08E-02 MIR4500 RRM2 1 (1) 1 RRM2 MIR5095 microRNA 1 1.000 8.17E-03 1.08E-02 MIR5095 RRM2 1 (1) 1 RRM2 PC enzyme -0.000 1 1.000 8.17E-03 2.27E-02 PC FASN 1 (1) 1 PPARA,PTN,RXRA phosphate PPDPF other 1 1.000 8.17E-03 2.27E-02 PPDPF FASN 1 (1) 1 PPP1R9B enzyme -0.000 1 -1.000 8.17E-03 8.60E-03 PPP1R9B PPP1CA 1 (1) 1 forskolin PPP1CA,RPS6KB1 Ca2+,Ppp1cc Pantr2 other 1 -1.000 8.17E-03 1.27E-02 Pantr2 POU3F3 1 (1) 1 RGL1 other 1 -1.000 8.17E-03 8.60E-03 RGL1 PPP1CA 1 (1) 1 TRIB1 GPS2 PPP1CA SAMD4B other 0.000 1 1.000 8.17E-03 1.37E-02 SAMD4B NANOS1 1 (1) 1 SPAST enzyme 0.000 1 1.000 8.17E-03 8.20E-03 SPAST EMX2 1 (1) 1 TBRG4 other 1 1.000 8.17E-03 1.08E-02 TBRG4 RRM2 1 (1) 1 RRM2 forchlorfenuron chemical reagent 1 1.000 8.17E-03 1.24E-02 forchlorfenuron SNAP25 1 (1) 1 miR-502-5p (and other miRNAs w/seed UCCUUGC) mature microRNA 1 1.000 8.17E-03 1.10E-02 miR-502-5p (and other miRNAs w/seed UCCUUGC) KMT5A 1 (1) 1 miR-99a-3p (and other miRNAs w/seed AAGCUCG) mature microRNA 1 1.000 8.17E-03 1.08E-02 miR-99a-3p (and other miRNAs w/seed AAGCUCG) RRM2 1 (1) 1 RRM2 vanoxerine chemical drug 1 -1.000 8.17E-03 1.28E-02 vanoxerine SOD3 1 (1) 1 SLC6A3,SOD3 ENG transmembrane receptor 2 0.258 8.20E-03 4.86E-02 ACVRL1,Akt,AKT1,CDKN1A,ENG,ITGB1,SMAD3,TGFBR1 AIMP2,ANGPT2,CEBPD,DGAT1,GLB1,HNRNPM,ITGB3,L1CAM,LRP6,MATR3,PLG,PTPRK,RRM2,TNFSF14,TNXB 15 (8) 8 GDF2,L-triiodothyronine,phytohemagglutinin,SOX7 SETD2,WNT3A CDH5,RAC2 AKT1,BCAR1,PDGFB SULF2 enzyme -0.000 2 0.000 8.22E-03 3.51E-02 Akt,ERK1/2,SMAD3,SULF2 AIMP2,ANGPT2,AOC1,BIRC3,DGAT1,FASN,ITGB3,L1CAM,PLG,PTPRK,RRM2,TNFSF14 12 (4) 3 deferoxamine,epicatechin,TREM2 DSPP,SOCS3 huaier extract granule chemical drug 2 0.000 8.23E-03 4.21E-02 Akt,ERBB2,GSK3B,huaier extract granule AIMP2,ANGPT2,BIRC3,DPY19L3,FASN,ITGB3,L1CAM,LRP6,PGK1,PLG,POLI,PTPRK,RRM2,TNFSF14 14 (4) 4 KIT,LRP6,WNT5A 1,2-dioctanoyl-sn-glycerol chemical reagent 2 0.000 8.24E-03 2.19E-02 1,2-dioctanoyl-sn-glycerol,AKT1,ALOX5,Ap1,Pkc(s) BIRC3,CALM1 (includes others),CEBPD,FASN,HNRNPM,ITGB3,KRT8,MATR3,PLG,RRM2 10 (5) 4 R59949 Ca2+ AKT1 Irgm1 other 1 0.000 8.28E-03 1.89E-02 Irgm1 CGAS,IFI44,RRM2,TRIM56 4 (1) 1 WNT3A PPARD,prednisolone CXCL10,RRM2,UBE2C,USP18 MAP4K4 kinase 0.000 2 -0.832 8.30E-03 3.86E-02 Ap1,EIF4EBP1,IKK (complex),Jnk,MAP3K1,MAP4K4,MAPK8,MAPK9 B4GALT1,BIRC2,BIRC3,CALM1 (includes others),CD209,CEBPD,CLEC10A,DGAT1,FASN,PLG,PLIN2,RRM2,SOD3 13 (8) 8 MAP3K11,Sapk ACADS,PLA2G6,RPS6KB1,RPS6KB2,SCD,SCP2 MEOX2 transcription regulator 0.000 2 -0.277 8.30E-03 3.53E-02 CDKN2A,MEOX2,NFkB (complex) ALDH7A1,B4GALT1,BIRC2,BIRC3,CEBPD,FAM111A,FASN,GLB1,ITGB3,KIFC1,RRM2,SOD3,TSG101 13 (3) 3 ZEB2 CDKN2A,NFkB (complex) ANGPT1,TNFSF4,TRAF1,VEGFC IGFBP6 other 2 -0.577 8.31E-03 2.51E-02 ERK,IGFBP6,MAPK8,P38 MAPK,VDR ADGRG6,ANGPT2,ANK1,B4GALT1,BIRC3,CEBPD,CUBN,DGAT1,FASN,ITGB3,PLIN2,PPP1CA 12 (5) 4 benzo(a)pyrene,forskolin,MDM2,RXRA,TMPRSS2-ERG BMP7,BTG2,caffeic acid phenethyl ester,captopril,L-triiodothyronine,levothyroxine,PPARD Z-YVAD-FMK chemical reagent 2 0.577 8.31E-03 3.37E-02 Ap1,CASP1,Jnk,NFkB (complex),Z-YVAD-FMK ALDH7A1,B4GALT1,BIRC2,BIRC3,CALM1 (includes others),CD209,CEBPD,CLEC10A,FASN,PLG,RRM2,SOD3 12 (5) 4 CASP3,NFkB (complex) iloprost chemical drug 1 -1.414 8.33E-03 9.80E-03 iloprost ANGPT2,PTGIR 2 (1) 1 Ca2+,Na+,K+ -ATPase indirubin chemical drug 1 1.414 8.33E-03 1.09E-02 indirubin BIRC2,BIRC3 2 (1) 1 NFkB (complex) clenbuterol chemical drug 2 -0.905 8.34E-03 2.91E-02 ADRB2,Akt,clenbuterol,EIF4EBP1,ERK1/2 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,ITGB3,L1CAM,PLG,RRM2,TNFSF14 11 (5) 4 SOCS3 DNM1 enzyme -0.000 2 -1.387 8.48E-03 3.49E-02 DNM1,ERK,ERK1/2,IRS1,MAPK1,MAPK3,MMP2 ADGRG6,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CEBPD,FASN,FLNC,IFI44,ITGB3,PLG,PTPRK 13 (7) 6 PPP3R1 IRS1 Dgk group 2 1.069 8.48E-03 4.72E-02 Akt,Dgk,EGFR,ERK1/2,Jnk AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CD209,CLEC10A,FASN,ITGB3,L1CAM,PLG,RRM2,TNFSF14,TNXB 14 (5) 4 chenodeoxycholic acid R59949 MINK1 kinase 2 -1.604 8.48E-03 4.38E-02 Akt,ERK1/2,MAPK14,MAPK9,MINK1,NR3C1 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,ITGB3,L1CAM,LRP6,PLG,PLIN2,RRM2,SOD3,TNFSF14 14 (6) 5 RBP1 transporter 2 1.069 8.48E-03 3.72E-02 Akt,AKT1,PI3K (complex),PPARG,RBP1 ACAA1,AIMP2,BIRC2,BIRC3,CEBPD,DGAT1,FASN,HNRNPM,L1CAM,MATR3,PLG,PLIN2,RRM2,TNFSF14 14 (5) 4 carbon tetrachloride,L-triiodothyronine,PPARD HOXA10,SCD RXRA AKT1 TACSTD2 other 2 -0.302 8.54E-03 3.47E-02 Akt,ERK,ERK1/2,TACSTD2 ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,L1CAM,PLG,RRM2,TNFSF14 11 (4) 3 camptothecin IgG,lactacystin Ca2+,NFkB (complex) Atf group 2 -0.707 8.55E-03 2.37E-02 Atf,ATF3,ATF4,ATF6 ANGPTL3,BIRC3,CHAC1,DUT,FASN,PLIN2,RAB11A,RRM2 8 (4) 3 ATF2,quercetin PDLIM1 transcription regulator -0.000 2 0.535 8.56E-03 4.67E-02 CTNNB1,NFkB (complex),PDLIM1 ACAA1,ALDH7A1,B4GALT1,BIRC2,BIRC3,CEBPD,EMX2,FASN,KIFC1,L1CAM,PGK1,PLIN2,SOD3,SUSD2 14 (3) 2 ammonium,PGR benzo(a)pyrene NFkB (complex) Frizzled group 2 -0.277 8.57E-03 4.37E-02 CTNNB1,Frizzled,FZD9,GSK3B,MAPK8,Pkc(s) ACAA1,B4GALT1,BIRC2,DGAT1,EMX2,FASN,IFI44,KIFC1,KRT8,L1CAM,PGK1,PLIN2,SUSD2 13 (6) 5 WNT1,WNT3A,WNT5A DKK,FRZB,L-triiodothyronine,WNT16 Dishevelled,DVL1 arecoline chemical drug 2 -0.577 8.60E-03 3.43E-02 Akt,arecoline,CHRNA7,ERK,PI3K (complex),PTPN11 ABCA3,ADGRG6,AIMP2,BIRC2,BIRC3,CEBPD,CHRNA10,FASN,ITGB3,L1CAM,PLG,TNFSF14 12 (6) 5 CHRM1,CHRM2,CHRNA4,HMOX1,PGF PPP3CA phosphatase 0.000 2 -1.897 8.69E-03 3.52E-02 Calcineurin protein(s),HTT,MAP3K7,Map3k7,MAPT,Nfat (family),NFATC1,PPP3CA,TAB1 ASPG,B4GALT1,BIRC2,BIRC3,FASN,IFI44,ITGB3,KRT8,TNFSF14,TSG101 10 (9) 9 Ca2+,PPP3R1,SOD1 LASP1,tacrolimus CAV3,CDH2,KRT18,POU2AF1 Map3k7,MAP3K7 sodium arsenate chemical toxicant 2 -1.155 8.80E-03 2.79E-02 ERK1/2,Jnk,MAPK8,P38 MAPK,PRKCD,sodium arsenate ANGPT2,ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,ITGB3,PLG 12 (6) 5 Mt G6PC3 phosphatase 0.000 2 Activated 2.121 8.83E-03 2.05E-02 AKT1,EIF2AK3,G6PC3 BIRC2,BIRC3,CEBPD,FASN,HNRNPM,MATR3,PLG,PNLIP 8 (3) 2 HNF4A AKT1,CASP3 F2RL3 G-protein coupled receptor 2 -1.508 8.97E-03 3.13E-02 Akt,ERK1/2,F2RL3,ITGB3,MAPT AIMP2,ANGPT2,AOC1,ASPG,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,TNFSF14 11 (5) 4 Ca2+ PCGF2 transcription regulator 0.000 2 1.890 8.98E-03 1.62E-02 AKT1,CDK2,PCGF2 BIRC3,CEBPD,FASN,HNRNPM,MATR3,PLG,SNAP25 7 (3) 2 MK2206,perifosine CCND2,CCNE1,CDH2,CDKN2A,ZEB2 quercetin chemical drug 1 0.816 8.98E-03 2.05E-02 quercetin BCHE,BIRC3,FASN,FCGBP,KRT8,THSD4 6 (1) 1 Atf,BHLHE40,Ca2+,Collagen type II,ESR2,GNAI3,GSTA1,HIPK2,HMOX1,Map3k7,NLRX1,PPP1R15A,PRKAA1,SLC5A5,SOD1,TFAM,WNT5A ACHE,BCAR4,caspase,CD63,CXCL10,fatty acid,Hsp90,IFNB1,KRT18,NADH,NFkB (complex),NQO2,oleic acid,PLAC8,PLD1,prostaglandin E2,RPS6KB1,TNFRSF11A,XDH anastrozole chemical drug 2 1.342 8.99E-03 1.84E-02 anastrozole,CYP19A1,CYP1A2 ASPG,CACHD1,FASN,GSTM3,PLIN2 5 (3) 2 PDC other 2 1.265 9.03E-03 2.97E-02 AKT1,MAPK1,PDC BIRC3,CEBPD,FASN,FLNC,HNRNPM,IFI44,ITGB3,MATR3,PLG,PTPRK 10 (3) 2 forskolin CX3CL1 AKT1 epicatechin chemical drug 2 0.775 9.10E-03 4.26E-02 epicatechin,IRS1,Jnk,NFkB (complex),P38 MAPK,PI3K (complex) ALDH7A1,ANK1,B4GALT1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,ITGB3,PLG,PLIN2,SNAP25,SOD3,SVEP1 15 (6) 6 ANGPTL4,MFAP2,SULF2 IRS1,NFkB (complex) 8-bromo-cAMP chemical reagent 1 0.000 9.15E-03 3.54E-02 8-bromo-cAMP AOC1,B4GALT1,BIRC3,FLNC,GLB1,HSD3B2,ITGB3,KRT8,LGMN,RRM2 10 (1) 1 AKT1,ATF2,BMP7,Ca2+,CAMP,CCND2,CGB3 (includes others),CHRM2,CYP2B6,DIO2,FGF9,FZD8,GNAI3,IL11,IL20,INHA,ITGA4,ITPR1,KIT,LIF,MDM2,MGAT5,MMP7,NTRK1,PDGFB,PDGFC,PDGFD,PDGFRA,PGR,PPARD,PTTG1,RAC2,RAPGEF1,RRM2,SLC2A1,SLC6A3,WNT16,WNT5A BCAR1,CASP3,IFNB1,KRT18,phosphatase,SFRP1,VEGFC glyceollin chemical - endogenous non-mammalian 2 1.508 9.18E-03 2.93E-02 Akt,AMPK,ERK,glyceollin,NOS3 ADGRG6,AIMP2,BIRC2,CEBPD,FASN,ITGB3,L1CAM,PLG,RRM2,SOD3,TNFSF14 11 (5) 4 ANGPT1 CF102 chemical drug 2 -1.732 9.20E-03 3.53E-02 Akt,CF102,ERK1/2,P38 MAPK AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CEBPD,ITGB3,L1CAM,PLG,RRM2,TNFSF14 12 (4) 3 HAS1 enzyme 2 -0.577 9.20E-03 3.98E-02 ERBB2,FAS,FASLG,HAS1 ANGPT2,BIRC2,BIRC3,CEBPD,DPY19L3,FASN,ITGB3,L1CAM,PGK1,POLI,PTPRK,RRM2 12 (4) 3 BHLHE40 FASLG P5091 chemical reagent 2 -0.577 9.20E-03 3.27E-02 ERK1/2,Jnk,KDM1A,P38 MAPK,P5091 ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,ITGB3,KRT8,PLG 12 (5) 4 beta-cyclodextrin chemical - endogenous non-mammalian 2 1.387 9.22E-03 3.22E-02 AKT1,beta-cyclodextrin,CAV1,CETP,ERK,IRS1,Jnk,P38 MAPK,PI3K (complex) ADGRG6,ANK1,BIRC3,CD209,CEBPD,CLEC10A,FASN,HNRNPM,ITGB3,LRP6,MATR3,PLG,PLIN2 13 (9) 9 AKT1,IRS1,PRNP capsazepine chemical toxicant 2 0.500 9.23E-03 4.88E-02 Ap1,capsazepine,ERK,ERK1/2,IKK (complex),Jnk,NFkB (complex),STAT1 ADGRG6,ALDH7A1,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,CALM1 (includes others),CASP2,CD209,CEBPD,CLEC10A,ITGB3,PLG,RRM2,SOD3 16 (8) 7 Ca2+,IL11,NFkB (complex),prostaglandin E2 calcium chloride chemical drug 2 0.000 9.27E-03 2.44E-02 calcium chloride,ERK1/2,MMP2,MMP9,PRKCE,TERT ANGPT2,AOC1,BIRC2,BIRC3,CHRNB3,GLB1,IFI44,ITGB3,L1CAM,PLG 10 (6) 5 Ca2+,CASP3,TERT teriflunomide chemical drug 2 Activated 2.496 9.31E-03 4.06E-02 Akt,ERK1/2,JINK1/2,MMP2,P38 MAPK,PDPK1,teriflunomide AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CEBPD,FASN,ITGB3,PLG,RAB11A,RRM2,TNFSF14 13 (7) 6 FASLG,MFN2 JINK1/2,TRPC6 ANGPTL4 other -0.000 1 0.000 9.32E-03 8.80E-03 ANGPTL4 FASN,PLIN2 2 (1) 1 anandamide,deferoxamine,EPAS1,epicatechin,oleic acid,PPARA,prostaglandin E2,tributyltin PPARD,SALL4,SCD ERN1 RAB2A enzyme -0.000 1 0.000 9.32E-03 1.44E-02 RAB2A FASN,PLIN2 2 (1) 1 thyroid hormone ACSL1,CIDEB,CIDEC SCP2 transporter -0.000 1 -1.414 9.32E-03 1.63E-02 SCP2 ACAA1,PLIN2 2 (1) 1 HNF4A,PPARA EHHADH,HSD17B4,MAP4K4 bile acid,fatty acid,LDL-cholesterol,phospholipid,sphingomyelin palmitoyl-coenzyme A chemical - endogenous mammalian 2 -0.816 9.37E-03 2.12E-02 26s Proteasome,G6PD,GCK,NME1,palmitoyl-coenzyme A,PNPLA8 ADRM1,BIRC2,BIRC3,DGAT1,FASN,L1CAM 6 (6) 5 SCD PNPLA8 TRPM2 ion channel -1.012 2 -1.897 9.39E-03 2.26E-02 AKT1,ERK1/2,TRPM2 ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,ITGB3,MATR3,PLG 10 (3) 2 Ca2+,cyclic ADP-ribose AKT1,SLC2A1 EPAS1 mir-145 microRNA 2 1.732 9.40E-03 3.68E-02 ABCA1,Akt,ERK1/2,IRS1,MAPK7,mir-145 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,ITGB3,L1CAM,PLG,RRM2,TNFSF14 12 (6) 5 Notch forskolin,HMOX1,PDGFB CDH2,DSPP,IRS1,MAPK7,PDGFRA,YES1 pamidronic acid chemical drug 2 1.732 9.40E-03 2.75E-02 Akt,ERK1/2,pamidronic acid,Pkc(s),RAS AIMP2,ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,ITGB3,KRT8,L1CAM,PLG,RRM2,TNFSF14 12 (5) 4 GGPS1 S-adenosylmethionine chemical - endogenous mammalian 2 0.905 9.40E-03 2.55E-02 ERK1/2,Jnk,MAPT,RYR2,S-adenosylmethionine ANGPT2,AOC1,ASPG,BIRC2,BIRC3,CD209,CLEC10A,FASN,ITGB3,KRT8,PLG 11 (5) 5 choline,L-methionine HMOX1,phospholipid bile acid,CASP3,Hsp90 cerebroside 3-sulfate chemical - endogenous mammalian 2 -1.604 9.45E-03 4.24E-02 cerebroside 3-sulfate,ERK,ERK1/2,Jnk,P38 MAPK,SP1,SRC ADGRG6,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PGK1,PLG,RRM2,SNAP25 14 (7) 6 ceramide RPS6KB2 kinase 2 -1.000 9.46E-03 2.74E-02 Akt,cytarabine,IRS1,RPS6KB2 AIMP2,BIRC2,CEBPD,FASN,L1CAM,PLG,PPP1CA,RRM2,TNFSF14 9 (4) 3 AKT1,INS AR-12,MAP4K4,RPS6KB1 CXCL10,IFNB1 SDF4 other -0.000 2 0.378 9.48E-03 2.18E-02 ERN1,Jnk,SDF4 BIRC3,CD209,CEBPD,CLEC10A,DGAT1,PLG,PLIN2 7 (3) 2 ERN1 dovitinib chemical drug 2 1.387 9.51E-03 4.21E-02 Akt,dovitinib,ERK,ERK1/2,SRC ADGRG6,AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,ITGB3,L1CAM,PGK1,PLG,RRM2,TNFSF14 13 (5) 4 FGFR3,PLC gamma benzamil chemical drug 2 0.632 9.51E-03 3.35E-02 Akt,benzamil,ERK1/2,NOS3 AIMP2,ANGPT2,AOC1,BIRC3,ITGB3,L1CAM,PLG,RRM2,SOD3,TNFSF14 10 (4) 3 Ca2+ Integrin alpha 3 beta 1 complex 2 -0.302 9.52E-03 3.55E-02 Integrin alpha 3 beta 1,ITGB1,MAPK8,NFKBIA B4GALT1,BIRC2,BIRC3,CEBPD,DGAT1,KRT8,LITAF,LRP6,NCAN,SOD3,TNXB 11 (4) 3 RELN,SLC3A2 sphingomyelin chemical - endogenous mammalian 2 -1.667 9.59E-03 2.26E-02 CFTR,ERK1/2,NTRK2,sphingomyelin ACAA1,ANGPT2,AOC1,BIRC2,BIRC3,CUBN,FASN,ITGB3,SNAP25 9 (4) 4 25-hydroxycholesterol,amitriptyline,CHKA fumonisin B1,SCP2 ceramide,Secretase gamma SCD NRG3 growth factor 2 -0.775 9.61E-03 4.68E-02 Akt,ERBB2,ERBB4,ERK1/2,NRG3 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,DPY19L3,FASN,ITGB3,L1CAM,PGK1,PLG,POLI,PTPRK,RRM2,TNFSF14 15 (5) 4 choline chemical - endogenous mammalian 2 -0.302 9.63E-03 3.41E-02 Ap1,choline,CHRNA7,EIF2AK3,IRS1,Jnk,PRKCD BIRC2,BIRC3,CALM1 (includes others),CD209,CEBPD,CHRNA10,CLEC10A,PLG,PNLIP,RRM2,SLC5A7 11 (7) 7 CHKA,Pi3k class I IRS1,S-adenosylmethionine HMOX1,PEMT CBLL1 enzyme 0.000 2 0.632 9.64E-03 3.83E-02 CBLL1,CDH1,CTNNB1 ACAA1,BIRC2,EMX2,FASN,ITGB3,KIFC1,L1CAM,PGK1,PLIN2,SUSD2 10 (3) 2 podophyllotoxin chemical drug 2 -1.508 9.74E-03 3.10E-02 Creb,ERK,Jnk,MAPK8,podophyllotoxin ADGRG6,B4GALT1,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,DPY19L3,ITGB3,PLG,RRM2 11 (5) 4 CDKN2A transcription regulator 1 -0.378 9.82E-03 2.96E-02 CDKN2A FAM111A,FASN,GLB1,ITGB3,KIFC1,RRM2,TSG101 7 (1) 1 camptothecin,cyclophosphamide,EP300,etoposide,KSR1,linsidomine,MEOX2,NMI,oleic acid,PENK,piceatannol,PPARA,PRNP,sodium azide,thyroid hormone,WNT1 caffeic acid phenethyl ester,daunorubicin,DBH-AS1,deferoxamine,FGF7,forskolin,L-triiodothyronine,levothyroxine,MAP2K2,miR-128-3p (and other miRNAs w/seed CACAGUG),PCGF2,prednisolone,SOD1,SPHK1,thiostrepton,ZEB2 ATR,BTG2,caspase,CCL3L3,CCR7,CCR9,CX3CL1,CXCL10,GABARAP,IL11,IL20,LOC102724788/PRODH,SH3BP2 CASP3,CCND2,CCNE1,CDK4/6,NFkB (complex),NOX4,POU5F1 3-deazaneplanocin chemical drug 2 -0.333 9.86E-03 2.45E-02 3-deazaneplanocin,SMAD3,STAT5A AKNA,BIRC3,CASP2,DGAT1,FASN,HSD3B2,PTPRK,SLC5A7,SNX33 9 (3) 3 IFNB1,PPP1R15A,SELENOS,TSC22D3 NOX4 chlorisondamine chemical drug 2 1.291 9.88E-03 4.52E-02 Akt,chlorisondamine,IL6,PI3K (complex) AIMP2,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FGL1,ITGB3,KRT8,L1CAM,LRP6,PLG,REG1A,RRM2,TNFSF14 15 (4) 3 PENK N-arachidonylglycine chemical - endogenous mammalian 2 -1.265 9.89E-03 2.51E-02 ERK1/2,Jnk,N-arachidonylglycine,P38 MAPK ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 10 (4) 3 Ca2+ NSC 270012 chemical reagent 2 -1.265 9.89E-03 2.51E-02 ERK1/2,Jnk,NSC 270012,P38 MAPK ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 10 (4) 3 imidazolo-oxindole PKR inhibitor C16 chemical reagent 2 1.265 9.89E-03 2.51E-02 ERK1/2,imidazolo-oxindole PKR inhibitor C16,Jnk,P38 MAPK ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 10 (4) 3 ATF2 transcription regulator -0.000 2 -1.941 1.00E-02 3.92E-02 ATF2,FOS,Jnk,JUN,P38 MAPK ANK1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,FASN,HSD3B2,ITGB3,KRT8,NUBP1,PLG,POLI 13 (5) 4 8-bromo-cAMP,anisomycin,ATR,deferoxamine,EP300,etoposide,GAST,JINK1/2,MAP3K20,MAP3K7,MSTN,NFkB (complex),phorbol-12,13-diacetate,piceatannol,PLD1,prostaglandin E2,RETN,Sapk,tolfenamic acid KN 93,leucine,S100A9,SDC4,tanespimycin Atf,ATF3,IFNB1,PDGFRA CD6 transmembrane receptor 2 -1.265 1.00E-02 2.51E-02 CD6,ERK1/2,Jnk,P38 MAPK ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 10 (4) 3 tacrolimus RRAD enzyme -0.000 2 -1.414 1.00E-02 3.04E-02 CaMKII,NME1,RB1,RRAD ANGPT2,BIRC3,CALCRL,CELSR1,H2BC21,L1CAM,MAPK4,RRM2 8 (4) 3 GnRH-A DSPP other -3.607 2 -1.265 1.01E-02 2.54E-02 DSPP,ERK1/2,Jnk,P38 MAPK ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 10 (4) 3 SULF2,TMSB4 LIF,mir-145 fluorofenidone chemical reagent 2 1.265 1.01E-02 2.61E-02 ERK1/2,fluorofenidone,Jnk,P38 MAPK ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 10 (4) 3 UBE2L3-KRAS fusion gene/product 2 0.000 1.01E-02 4.82E-02 Akt,ERK1/2,Mek,P38 MAPK,UBE2L3-KRAS AIMP2,ANGPT2,ANK1,AOC1,BIRC3,CASP2,CEBPD,FASN,L1CAM,PLG,RRM2,TNFSF14 12 (5) 4 3-nitrobenzanthrone chemical toxicant 2 Inhibited -2.000 1.02E-02 1.70E-02 3-nitrobenzanthrone,CYP1A1,CYP1A2,NQO1 BIRC2,BIRC3,CACHD1,GSTM3 4 (4) 3 POR acetyl-L-carnitine chemical - endogenous mammalian 2 0.000 1.02E-02 2.14E-02 acetyl-L-carnitine,ERK1/2,IRS1,MAPT ANGPT2,AOC1,ASPG,BIRC2,BIRC3,CEBPD,FASN,ITGB3 8 (4) 3 PPARA,TFAM IRS1 MMP7 peptidase 2 -1.941 1.02E-02 3.57E-02 AKT1,ERK1/2,IGF1R,KDR,MMP2,MMP7,MMP9 ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,HSD3B2,ITGB3,L1CAM,MATR3,PLG,RRM2 13 (7) 6 8-bromo-cAMP,BCAR1,Collagen type II,EP300,ETV1,GAST,LRP6,MAP3K11,mir-154,RAP1A,S100A9,WNT5A Ca2+,doxycycline,lycopene,NR5A2 AKT1 BMP7,TFPI AGI-1095 chemical reagent 2 1.265 1.03E-02 2.67E-02 AGI-1095,ERK1/2,Jnk,P38 MAPK ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 10 (4) 3 P4HTM enzyme -0.000 2 1.265 1.03E-02 2.65E-02 ERK1/2,Jnk,P38 MAPK,P4HTM ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 10 (4) 3 EPAS1 oblimersen biologic drug 1 0.577 1.03E-02 1.55E-02 oblimersen CEBPD,IFI44,SULT1A2 3 (1) 1 ATF3 PHLPP1 enzyme 0.000 2 1.604 1.03E-02 4.63E-02 Akt,ERK1/2,PHLPP1,Pkc(s),PRKCB,RAF1 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,ITGB3,KRT8,L1CAM,PLG,RRM2,SLC16A7,TNFSF14 14 (6) 6 irinotecan,tunicamycin IFNB1,IRS1 RPS6KB1 5R-hydroxytriptolide chemical drug 2 1.265 1.04E-02 2.61E-02 5R-hydroxytriptolide,ERK1/2,Jnk,P38 MAPK ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 10 (4) 3 AGI-1067 chemical drug 2 1.265 1.04E-02 2.70E-02 AGI-1067,ERK1/2,Jnk,P38 MAPK ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 10 (4) 3 POR enzyme 0.000 2 -0.632 1.04E-02 3.32E-02 Akt,mitomycin C,NOS3,POR AIMP2,BIRC2,FGL1,L1CAM,PLG,RRM2,SOD3,SUSD2,TNFSF14,TULP4 10 (4) 4 GAST,L-triiodothyronine daunorubicin,gimeracil,HNF4A,nitazoxanide,oxonic acid,tegafur 14,15-epoxyeicosatrienoic acid,3-nitrobenzanthrone,ACSL1,bile acid,mitomycin C caspase,MAP3K6,SCD ITGA4 transmembrane receptor 0.000 2 -0.905 1.04E-02 3.51E-02 Akt,ERK1/2,Focal adhesion kinase,ITGA4,PTK2 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,KRT8,L1CAM,PLG,RRM2,TNFSF14 11 (5) 4 8-bromo-cAMP,BHLHE40,CCR7,MFAP2,VEGFC LASP1,mir-182,miR-182-5p (and other miRNAs w/seed UUGGCAA),prednisolone,WNT5A Focal adhesion kinase,LCP2,RAC2 SLC5A5 transporter 0.000 3 1.155 1.05E-02 3.01E-02 AKT1,ERK1/2,LIPE,PI3K (complex),SLC5A5,SRC (family) ABCA3,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,ITGB3,MATR3,PLG,PLIN2 12 (6) 6 AKT1,forskolin,quercetin ceramide,deferoxamine,doxycycline,iodine,PTTG1 DIO1,L-triiodothyronine CCX832 chemical reagent 2 0.707 1.05E-02 1.92E-02 CCX832,ERK1/2,Jnk ANGPT2,AOC1,BIRC2,BIRC3,CD209,CLEC10A,ITGB3,PLG 8 (3) 2 ML171 chemical reagent 2 0.707 1.05E-02 1.92E-02 ERK1/2,Jnk,ML171 ANGPT2,AOC1,BIRC2,BIRC3,CD209,CLEC10A,ITGB3,PLG 8 (3) 2 GPAM enzyme -0.000 2 0.832 1.05E-02 4.98E-02 Akt,GPAM,MTORC2,NFkB (complex),PRKCE AIMP2,ALDH7A1,B4GALT1,BIRC2,CEBPD,CHRNB3,FASN,L1CAM,PLG,PLIN2,RRM2,SOD3,TNFSF14 13 (5) 5 ACSS2,fatty acid,GPAT3,PTN,STK24,sucrose PPARD,PRKAA1 NFkB (complex) C1GALT1C1 other 2 -1.897 1.05E-02 2.84E-02 Akt,C1GALT1C1,ERK,KDR ADGRG6,AIMP2,ANGPT2,BIRC2,CEBPD,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (4) 3 MED28 other -0.000 2 -1.265 1.05E-02 2.66E-02 ERK1/2,Jnk,MED28,P38 MAPK ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 10 (4) 3 PF-3758309 chemical drug 2 1.265 1.05E-02 3.10E-02 Akt,ERK,NUMB,PF-3758309 ADGRG6,AIMP2,BIRC2,BIRC3,CEBPD,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (4) 3 Cofilin TJP1 rivastigmine chemical drug 3 0.632 1.05E-02 3.44E-02 ACHE,Gsk3,MAPT,MMP2,MMP9,MPO,NOS3,PRKAA2,PRKCE,rivastigmine,SERPINE1 ASPG,BIRC3,CHRNB3,FASN,IFI44,ITGB3,L1CAM,PLG,SLC5A7,SOD3 10 (11) 9 acetylcholine ACHE 4-hydroxycinnamyl aldehyde chemical - endogenous non-mammalian 2 -0.333 1.06E-02 3.84E-02 4-hydroxycinnamyl aldehyde,ERK1/2,Jnk,P38 MAPK ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,PLG 9 (4) 3 Ca2+ CDH2 PRCP peptidase -0.000 2 -0.333 1.06E-02 3.14E-02 Akt,IRS1,PI3K (family),PRCP,PROC AIMP2,ANGPT2,BIRC2,BIRC3,CEBPD,L1CAM,PLG,RRM2,TNFSF14 9 (5) 4 FOXO4 KLKB1 IRS1,levothyroxine aloxistatin chemical - protease inhibitor 2 1.155 1.06E-02 4.13E-02 aloxistatin,CASP1,Jnk,MMP2,MMP9,P38 MAPK,Pkc(s),SMAD3 ANK1,BIRC3,CD209,CEBPD,CLEC10A,DGAT1,FASN,ITGB3,KRT8,L1CAM,PLG,PTPRK 12 (8) 7 CASP3,FASLG capivasertib chemical drug 2 1.732 1.06E-02 4.80E-02 Akt,AKT1,capivasertib,NOTCH1 AIMP2,CEBPD,FASN,HNRNPM,KRT8,L1CAM,MATR3,PGK1,PLG,PTPRK,RRM2,TNFSF14 12 (4) 3 CASP3 AKT1,TREM2 GSKIP other -0.000 2 1.265 1.08E-02 4.64E-02 CTNNB1,GSK3B,GSKIP ACAA1,BIRC2,BIRC3,EMX2,FASN,KIFC1,L1CAM,PGK1,PLIN2,SUSD2 10 (3) 2 NME7 kinase 0.000 2 1.265 1.08E-02 4.64E-02 CTNNB1,GSK3B,NME7 ACAA1,BIRC2,BIRC3,EMX2,FASN,KIFC1,L1CAM,PGK1,PLIN2,SUSD2 10 (3) 2 PIK3IP1 other 2 Activated 2.111 1.08E-02 3.36E-02 Akt,AKT1,PI3K (complex),PIK3IP1 AIMP2,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,L1CAM,MATR3,PLG,RRM2,TNFSF14 11 (4) 3 INHA,Notch oleic acid,S100A9 AKT1 5-hydroxydecanoic acid chemical - endogenous mammalian 2 0.707 1.08E-02 2.46E-02 5-hydroxydecanoic acid,Jnk,MAPK14,MAPK8 B4GALT1,CD209,CEBPD,CLEC10A,DGAT1,FASN,LRP6,PLG 8 (4) 3 CASP3 tetracaine chemical drug 3 0.000 1.08E-02 1.53E-02 ACHE,Gsk3,MAPT,PRKCE,Ryr,RYR2,tetracaine ASPG,BIRC3,CHRNB3,FASN,KRT8,SLC5A7 6 (7) 5 ACHE PI4K2A kinase 2 -0.832 1.09E-02 4.93E-02 Akt,ERBB2,PI4K2A AIMP2,ANGPT2,BIRC2,DPY19L3,FASN,ITGB3,L1CAM,PGK1,PLG,POLI,PTPRK,RRM2,TNFSF14 13 (3) 2 GABARAP,GABARAPL1,GABARAPL2 origanum majorana extract chemical reagent 2 -0.333 1.09E-02 3.78E-02 MMP2,MMP9,NFKBIA,origanum majorana extract BIRC2,BIRC3,CEBPD,KRT8,L1CAM,LITAF,NCAN,PLG,SOD3 9 (4) 3 PPP1R15A other 2 -0.632 1.09E-02 3.34E-02 Akt,ERK1/2,PPP1R15A AIMP2,ANGPT2,AOC1,BIRC3,ITGB3,L1CAM,PLG,RRM2,SNAP25,TNFSF14 10 (3) 3 (1S,2R)-NCL-1,3-deazaneplanocin,ATF3,GnRH-A,mitomycin C,NCD-38,nelfinavir,quercetin,tunicamycin,Z36 CISH,GW3965,IgG,iron,leucine,MFN2,prostaglandin E2 IFNB1 mevastatin chemical drug 2 1.155 1.09E-02 4.66E-02 CDK2,CDK5,mevastatin,NR1I2,Ras homolog,RB1 ANGPT2,CALCRL,CELSR1,CYP39A1,GLB1,GSTM3,H2BC21,HSD3B2,ITGB3,MAPK4,RRM2,SNAP25 12 (6) 5 prostaglandin E2 miR-217-5p (and other miRNAs w/seed ACUGCAU) mature microRNA 2 0.000 1.10E-02 2.79E-02 LPIN1,miR-217-5p (and other miRNAs w/seed ACUGCAU),SIRT1 BIRC3,CLEC10A,DGAT1,FASN,HCRTR2,IFI44,SOD3,TSG101 8 (3) 3 LPIN1,PPARA,SCD VLDL complex 2 1.000 1.10E-02 3.20E-02 Akt,Jnk,VLDL AIMP2,BIRC2,BIRC3,CD209,CLEC10A,L1CAM,PLIN2,RRM2,TNFSF14 9 (3) 3 SCD PPARA,PPARD LASP1 transporter -0.000 2 -1.732 1.11E-02 4.20E-02 Akt,ERK,LASP1,Mek,PPP3CA,SRC (family) ADGRG6,AIMP2,BIRC2,CASP2,CEBPD,FASN,ITGB3,KRT8,L1CAM,PLG,RRM2,TNFSF14 12 (6) 5 8-(4-chlorophenylthio)-guanosine-3', 5'-cyclic monophosphate CDK4/6,SALL4 ITGA4,PPP3CA carboxyamido-triazole chemical drug 2 -0.632 1.11E-02 3.54E-02 Akt,carboxyamido-triazole,ERK,MAPK3,MMP2 ADGRG6,AIMP2,B4GALT1,BIRC2,CEBPD,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (5) 4 Ca2+ TMPRSS2-ERG fusion gene/product 3 Activated 2.496 1.11E-02 4.67E-02 Akt,AKT1,FOLH1,MTOR,p70 S6k,TMPRSS2-ERG AIMP2,BIRC2,BIRC3,CHAC1,FASN,HNRNPM,IFI44,L1CAM,MATR3,MEGF6,PLG,RRM2,TNFSF14 13 (6) 5 DYSF,IGFBP6,MME,TGFBI,VEGFC,ZEB2 DUSP8 STAMBPL1 enzyme 2 0.378 1.11E-02 2.35E-02 DUSP1,Jnk,STAMBPL1 BIRC3,CD209,CLEC10A,IFI44,PLG,PLIN2,PTPRK 7 (3) 2 WNT5A 4-(2-aminoethyl)benzenesulfonylfluoride chemical - protease inhibitor 2 -0.707 1.12E-02 2.92E-02 4-(2-aminoethyl)benzenesulfonylfluoride,IRF3,Jnk,NFkB (family) ANOS1,BIRC2,BIRC3,CD209,CLEC10A,IFI44,PLG,RRM2 8 (4) 3 HMOX1 ACSS2,IFNB1 doramapimod chemical drug 2 Activated 2.111 1.12E-02 3.56E-02 doramapimod,MAPK14,MAPK8,MAPK9,P38 MAPK,TERT ANK1,B4GALT1,BIRC3,CEBPD,DGAT1,GLB1,IFI44,ITGB3,LRP6,PLIN2,SOD3 11 (6) 5 TERT HAS2 CR1L transmembrane receptor 2 -1.941 1.13E-02 4.89E-02 Akt,CR1L,ERK,Jnk,P38 MAPK ADGRG6,AIMP2,ANK1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,L1CAM,PLG,RRM2,TNFSF14 13 (5) 4 VAV1 AR-42 chemical drug 2 Activated 2.121 1.13E-02 2.86E-02 AKT1,AR-42,Hdac BIRC3,CEBPD,EMX2,FASN,HNRNPM,LRP4,MATR3,PLG 8 (3) 2 AKT1 KDM3A transcription regulator 2 -0.707 1.13E-02 2.52E-02 ERK1/2,KDM3A,MMP9 ANGPT2,AOC1,BIRC2,BIRC3,FLNC,ITGB3,L1CAM,TNXB 8 (3) 3 BHLHE40,EP300,Hsp90 HMOX1 fatty acid gamma tocopherol chemical drug 2 1.897 1.13E-02 2.58E-02 AKT1,ERK1/2,gamma tocopherol,PTGS2 ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,ITGB3,MATR3,PLG 10 (4) 3 CASP3 AKT1 DETA-NONOate chemical reagent 1 -0.577 1.14E-02 1.48E-02 DETA-NONOate BIRC2,BIRC3,SOD3 3 (1) 1 CNN1,EIF2AK1,HMOX1,SOD3,TERT,TNFSF4 ADAM10,AKT1,NFkB (complex) Il11r group 2 -1.941 1.14E-02 4.62E-02 ERK1/2,Il11r,IL6ST,PTPN11,STAT3 ABCA3,ANGPT2,AOC1,BIRC2,BIRC3,CD209,CEBPD,CGAS,FASN,ITGB3,PGK1,RRM2,SLC5A7 13 (5) 4 IL11 ZFPM2 transcription regulator 2 0.832 1.14E-02 4.90E-02 Akt,ERK,GATA4,Gsk3,PI3K (complex),ZFPM2 ADGRG6,AIMP2,BIRC2,BIRC3,CEBPD,EMX2,FASN,HSD3B2,ITGB3,L1CAM,PLG,RRM2,TNFSF14 13 (6) 5 NF-Y complex 1 -1.414 1.14E-02 1.74E-02 NF-Y FASN,RRM2 2 (1) 1 IBSP,LPIN1,RRM2 dacinostat chemical drug 1 1.414 1.14E-02 1.92E-02 dacinostat ANGPT2,CEBPD 2 (1) 1 CASP3 plumbagin chemical drug 1 1.414 1.14E-02 1.22E-02 plumbagin BIRC2,BIRC3 2 (1) 1 CASP3 NFkB (complex),prostaglandin E2,SLC2A1 N,N-dimethylarginine chemical - endogenous mammalian 2 -1.667 1.15E-02 3.43E-02 Jnk,N,N-dimethylarginine,NOS2,NOS3,P38 MAPK ANK1,BIRC3,CD209,CEBPD,CLEC10A,FASN,ITGB3,PLG,SOD3 9 (5) 4 HMOX1 peroxynitrite TJP1 7,8-dihydroxyflavone chemical - endogenous non-mammalian 2 -1.897 1.15E-02 3.70E-02 7,8-dihydroxyflavone,Akt,ERK,NTRK2 ADGRG6,AIMP2,BIRC2,CEBPD,ITGB3,L1CAM,PLG,RRM2,SNAP25,TNFSF14 10 (4) 3 moxifloxacin chemical drug 2 0.707 1.15E-02 2.06E-02 ERK1/2,Jnk,moxifloxacin ANGPT2,AOC1,BIRC2,BIRC3,CD209,CLEC10A,ITGB3,PLG 8 (3) 2 LAX1 other 2 Activated 2.496 1.15E-02 4.28E-02 Akt,AKT1,LAX1,P38 MAPK,PI3K (complex) AIMP2,ANK1,BIRC2,BIRC3,CEBPD,FASN,HNRNPM,ITGB3,L1CAM,MATR3,PLG,RRM2,TNFSF14 13 (5) 4 LAT2 AKT1 NR5A2 ligand-dependent nuclear receptor -0.000 1 0.000 1.16E-02 2.05E-02 NR5A2 CEBPD,FASN,HSD3B2,PNLIP 4 (1) 1 bile acid,chenodeoxycholic acid,L-triiodothyronine,NCOA3,prostaglandin E2,RXRA,WNT3A GW3965,NR0B1,PROX1 FGF19,HTRA1,INHA,KRT18,LHB,PGR,POU5F1,taurocholic acid acetylcholine,CXCL10,MMP7,RGS4,SAA1,tauroursodeoxycholic acid lead nitrate chemical toxicant 2 -1.265 1.16E-02 3.18E-02 ERK1/2,Jnk,lead nitrate,P38 MAPK ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 10 (4) 3 N1,N11-diethylnorspermine chemical drug 2 -0.277 1.16E-02 4.78E-02 ERK1/2,MAPK8,N1,N11-diethylnorspermine,P38 MAPK,RB1 ANK1,AOC1,B4GALT1,BIRC2,BIRC3,CALCRL,CEBPD,CELSR1,DGAT1,H2BC21,ITGB3,MAPK4,RRM2 13 (5) 4 CASP3 TAOK2 kinase 2 -1.732 1.18E-02 4.26E-02 Jnk,MAP2K4,MAPK14,MAPK8,MAPT,Mek,P38 MAPK,TAOK2 ANK1,ASPG,B4GALT1,BIRC3,CASP2,CD209,CEBPD,CLEC10A,DGAT1,ITGB3,LRP6,PLG 12 (8) 7 sorbitol deferoxamine Sapk PGR NSC 95397 chemical reagent 2 -1.265 1.19E-02 3.34E-02 ERK1/2,Jnk,NSC 95397,P38 MAPK ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 10 (4) 3 CASP3 DYRK3 kinase 2 0.000 1.22E-02 3.05E-02 DYRK3,Histone h3,SIRT1 BIRC3,CLEC10A,FASN,HCRTR2,IFI44,RRM2,SOD3,TSG101 8 (3) 2 S100A9 bergamottin chemical - endogenous non-mammalian 2 1.897 1.24E-02 3.59E-02 bergamottin,CYP1A2,MAPK8,MMP2,MMP9,P38 MAPK ANK1,B4GALT1,BIRC3,CACHD1,CEBPD,DGAT1,GSTM3,ITGB3,L1CAM,PLG 10 (6) 5 CYP2B6 RSU1 other -0.000 2 0.302 1.24E-02 4.72E-02 Jnk,MAPK1,MAPK9,RSU1 BIRC3,CD209,CLEC10A,FASN,FLNC,IFI44,ITGB3,PLG,PLIN2,PTPRK,SOD3 11 (4) 3 PRKAA1 kinase 1 -1.342 1.24E-02 2.77E-02 PRKAA1 BIRC3,H2BC21,HSD3B2,IFI44,LITAF 5 (1) 1 CAB39L,CCR7,CDH2,CNTF,G protein beta gamma,Map3k7,MAP3K7,peroxynitrite,phenformin,PROCR,quercetin,sorbitol CRBN,oleic acid,prednisolone AKT1,ATF3,CYP2B6,EP300,ERN1,GSTA1,IFNB1,IRS1,Na+,K+ -ATPase,RPS6KB1,SOCS3,TFAM GPAM,PDGFRA,SLC2A1,TJP1 ASIC1 ion channel 0.000 2 -1.508 1.25E-02 4.34E-02 26s Proteasome,Akt,ASIC1,ERK,PRKCI ADGRG6,ADRM1,AIMP2,BIRC3,CEBPD,FASN,ITGB3,L1CAM,PLG,RRM2,TNFSF14 11 (5) 4 FGFR4 kinase 0.000 1 0.000 1.26E-02 2.04E-02 FGFR4 DGAT1,FASN 2 (1) 1 carbon tetrachloride,FGF19 INHA,PD173074 JINK1/2 bile acid,CDH2 LPIN1 phosphatase 1 0.000 1.26E-02 9.40E-03 LPIN1 DGAT1,FASN 2 (1) 1 4beta-hydroxycholesterol,CREB3L3,GW3965,NF-Y,NPY,tolylfluanid Ca2+,miR-217-5p (and other miRNAs w/seed ACUGCAU),oleic acid,tunicamycin PPARA RETN MDL 73811 chemical reagent 1 -1.414 1.26E-02 2.30E-02 MDL 73811 GLB1,ITGB3 2 (1) 1 LGALS3BP evodiamine chemical - endogenous non-mammalian 1 1.414 1.26E-02 8.50E-03 evodiamine BIRC2,BIRC3 2 (1) 1 CASP3 NFkB (complex) MMD kinase 2 -1.265 1.27E-02 3.77E-02 Akt,ERK1/2,MMD AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (3) 2 PPARA,WNT3A EP300 MOSPD2 other 0.000 2 -1.265 1.27E-02 3.77E-02 Akt,ERK1/2,MOSPD2 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (3) 2 AKT1 PKDCC kinase -0.000 2 -1.265 1.27E-02 3.77E-02 Akt,ERK1/2,PKDCC AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (3) 2 Q1047 chemical reagent 2 -1.265 1.27E-02 3.77E-02 Akt,ERK1/2,Q1047 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (3) 2 Q112 chemical reagent 2 -1.265 1.27E-02 3.77E-02 Akt,ERK1/2,Q112 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (3) 2 Q525 chemical reagent 2 -1.265 1.27E-02 3.77E-02 Akt,ERK1/2,Q525 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (3) 2 TMEM176B other 2 1.265 1.27E-02 3.77E-02 Akt,ERK1/2,TMEM176B AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (3) 2 LIF methyllycaconitine chemical toxicant 2 -0.905 1.27E-02 4.40E-02 Akt,ERK,MAPT,methyllycaconitine,SRC ADGRG6,AIMP2,ASPG,BIRC2,CEBPD,ITGB3,L1CAM,PGK1,PLG,RRM2,TNFSF14 11 (5) 4 GDF2 growth factor 2 -0.577 1.27E-02 4.71E-02 ACVRL1,Akt,GDF2,MAPK8,MMP9 AIMP2,ANGPT2,B4GALT1,BIRC2,BIRC3,DGAT1,FASN,L1CAM,NCAN,PLG,RRM2,TNFSF14 12 (5) 5 acetylcholine,CNTF,DLX5,ENG,FGFR3,HTRA1,MDFI,NPY,NTRK1,SEMA3B,SLC3A2 PROX1,SCD triiodothyronine, reverse chemical - endogenous mammalian 2 -1.155 1.27E-02 3.82E-02 Akt,CFTR,DIO2,PI3K (complex),SRC,triiodothyronine, reverse ACAA1,AIMP2,BIRC2,BIRC3,CUBN,L1CAM,PGK1,PLG,RRM2,SERINC2,SYCE2,TNFSF14 12 (6) 5 Na+,K+ -ATPase DIO2,TAT ERN1 kinase -0.000 1 -1.000 1.27E-02 2.89E-02 ERN1 CEBPD,DGAT1,FASN,PLIN2 4 (1) 1 (1S,2R)-NCL-1,1-methyl-4-phenylpyridinium,6-hydroxydopamine,carbon tetrachloride,INS,mitomycin C,MLN7243,NCD-38,PARP16,PEMT,phenformin,PRKAA1,RETREG1,tunicamycin,Z36 19,20-epoxydocosapentaenoic acid,4-phenylbutyric acid,ANGPTL4,CDN1163,CRBN,ESR2,kb-NB 142-70,LPCAT1,Mt,RPL22,SDF4,SPHK1 NCOA3,NFkB (complex),NOX4,PPARA,Sapk,SELENOS ATF3,SCD CIDEC other 2 -1.000 1.28E-02 3.73E-02 Akt,CIDEC,PNPLA2 AIMP2,BIRC2,DGAT1,FASN,L1CAM,PLG,PLIN2,RRM2,TNFSF14 9 (3) 3 forskolin,HNF4A,INS,RAB2A GW3965,N-cor fatty acid,SCD ACADS,DIO2 MTSS1 other 0.000 2 -1.265 1.28E-02 3.89E-02 Akt,ERK1/2,MTSS1 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (3) 2 NFkB (complex),PGR mir-182,miR-182-5p (and other miRNAs w/seed UUGGCAA) ALDH3A1 enzyme 2 1.000 1.29E-02 4.26E-02 26s Proteasome,ALDH3A1,RB1 ADRM1,ANGPT2,BIRC2,BIRC3,CALCRL,CELSR1,H2BC21,MAPK4,RRM2 9 (3) 2 benz[a]anthracene,benzo(a)pyrene CDX1,forskolin,tosylphenylalanyl chloromethyl ketone CASP3 VEGFD growth factor 0.000 2 -1.732 1.29E-02 4.41E-02 Akt,ERK1/2,KDR,P38 MAPK,VEGFD AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CEBPD,ITGB3,L1CAM,PLG,RRM2,TNFSF14 12 (5) 4 Ca2+ HMOX1 VEGFC GKAP1 other -0.000 2 -1.414 1.29E-02 3.24E-02 Akt,GKAP1,IRS1 AIMP2,BIRC2,CEBPD,FASN,L1CAM,PLG,RRM2,TNFSF14 8 (3) 2 IRS1 PID1 other 2 1.414 1.29E-02 3.24E-02 Akt,IRS1,PID1 AIMP2,BIRC2,CEBPD,FASN,L1CAM,PLG,RRM2,TNFSF14 8 (3) 2 GPS2 IRS1 SCH79797 chemical reagent 2 0.302 1.29E-02 4.51E-02 ERK1/2,Jnk,NFKBIA,SCH79797 ANGPT2,AOC1,CD209,CEBPD,CLEC10A,ITGB3,KRT8,LITAF,NCAN,PLG,SOD3 11 (4) 3 PLCB3 Pi3k class I complex 2 -0.632 1.30E-02 4.24E-02 Akt,NOS3,Pi3k class I,PIK3CG AIMP2,BIRC2,FASN,ITGB3,KRT8,L1CAM,PLG,RRM2,SOD3,TNFSF14 10 (4) 4 CHKA,choline,phosphatidylinositol,phosphatidylinositol 3,4-diphosphate,RPS6KB1,SLC2A1 CCL7 cytokine 2 -1.508 1.31E-02 4.19E-02 Akt,CCL7,ERK1/2,GNA12 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,PPP1CA,RRM2,TNFSF14 11 (4) 3 CAMP,Collagen type II,IFNB1,IL27,NFkB (complex) Ca2+ MORF4L1 other -0.000 3 -1.508 1.31E-02 4.20E-02 Akt,BCL2,CDK2,ERK,MORF4L1,MYBL2,OAS1,RNASEL ADGRG6,AIMP2,BIRC2,CEBPD,FAT4,ITGB3,L1CAM,PLG,RRM2,SNAP25,TNFSF14 11 (8) 6 SHCBP1 other 2 Inhibited -2.111 1.31E-02 4.11E-02 Akt,ERK,Mek,SHCBP1 ADGRG6,AIMP2,BIRC2,CASP2,CEBPD,FASN,ITGB3,L1CAM,PLG,RRM2,TNFSF14 11 (4) 3 AZ-23 chemical drug 2 1.897 1.31E-02 4.06E-02 Akt,AZ-23,ERK,NTRK2 ADGRG6,AIMP2,BIRC2,CEBPD,ITGB3,L1CAM,PLG,RRM2,SNAP25,TNFSF14 10 (4) 3 NTRK1 CLEC4C other 2 -1.265 1.31E-02 3.90E-02 Akt,CLEC4C,ERK1/2 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (3) 2 IFNB1 onapristone chemical drug 2 1.265 1.31E-02 4.84E-02 Ap1,estrogen receptor,onapristone,PGR BIRC2,BIRC3,CALM1 (includes others),CEBPD,FLNC,GSTM3,IFI44,KRT8,RRM2,SNAP25 10 (4) 3 PGR,PMP22,SPHK1 PIN4 enzyme -0.000 2 -1.414 1.31E-02 3.26E-02 Akt,IRS1,PIN4 AIMP2,BIRC2,CEBPD,FASN,L1CAM,PLG,RRM2,TNFSF14 8 (3) 2 IRS1 calcimycin/tetradecanoylphorbol acetate chemical reagent 2 0.000 1.31E-02 3.49E-02 calcimycin/tetradecanoylphorbol acetate,NFKBIA,WWOX BIRC2,BIRC3,CEBPD,KRT8,LITAF,NCAN,SOD3,TRIM2 8 (3) 2 4-methyl umbelliferone-8-carbaldehyde chemical reagent 2 1.732 1.32E-02 4.99E-02 4-methyl umbelliferone-8-carbaldehyde,Akt,ERK1/2,P38 MAPK,p70 S6k AIMP2,ANGPT2,ANK1,AOC1,BIRC2,BIRC3,FASN,ITGB3,L1CAM,PLG,RRM2,TNFSF14 12 (5) 4 NCOA3 captopril chemical drug 2 0.302 1.32E-02 4.41E-02 AKT1,AMPK,AVP,captopril,ERK1/2,MMP9 ANGPT2,AOC1,BIRC2,CEBPD,FASN,GSTM3,HNRNPM,ITGB3,L1CAM,MATR3,RRM2 11 (6) 6 AKT1,HMOX1,prostaglandin E2 CCR9,GNAI3,IGFBP6 GGPS1 enzyme -0.000 2 -0.378 1.33E-02 2.18E-02 ERK1/2,GGPS1,IRS1 ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,ITGB3 7 (3) 2 pamidronic acid,risedronic acid,zoledronic acid IRS1 lithocholic acid acetate chemical reagent 2 Inhibited -2.111 1.34E-02 4.73E-02 ERK1/2,lithocholic acid acetate,RAF1,VDR ANGPT2,AOC1,BIRC2,BIRC3,CUBN,FASN,ITGB3,PLIN2,PPP1CA,RRM2,SLC16A7 11 (4) 3 zinc chloride chemical reagent 2 Inhibited -2.333 1.34E-02 4.37E-02 ACHE,Hif1,PRMT5,RB1,zinc chloride ANGPT2,CALCRL,CELSR1,FASN,H2BC21,MAPK4,PGK1,RRM2,SLC5A7 9 (5) 4 RPS6KB1 ACHE NUCB2 other 0.000 2 -1.265 1.36E-02 3.93E-02 Akt,ERK1/2,NUCB2 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (3) 2 Ca2+ Ulbp group 2 -1.265 1.36E-02 4.05E-02 Akt,ERK1/2,Ulbp AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (3) 2 KLRC4-KLRK1/KLRK1 ZNF622 other -0.000 2 -1.667 1.36E-02 3.25E-02 Ap1,Jnk,MYBL2,P38 MAPK,ZNF622 ANK1,BIRC3,CALM1 (includes others),CD209,CEBPD,CLEC10A,ITGB3,PLG,RRM2 9 (5) 4 HOXA10 transcription regulator 1 0.447 1.36E-02 3.62E-02 HOXA10 AIMP2,BCHE,EMX2,ITGB3,TNXB 5 (1) 1 doxycycline FAF1 DBP,IL11,KRT18,MFNG,PROS1,RBP1,RHOG,SCD,XDH AKT1 kinase 1 -1.633 1.37E-02 2.45E-02 AKT1 BIRC3,CEBPD,FASN,HNRNPM,MATR3,PLG 6 (1) 1 14,15-epoxyeicosatrienoic acid,4-phenylbutyric acid,6-hydroxydopamine,8-bromo-cAMP,[D-Ala2,N-Me-Phe4,Gly5-ol]-Enkephalin,AKTIP,anandamide,arginine,ARHGAP32,BDKRB2,bisperoxo(5-hydroxypyridine-2-carboxyl)oxovanadate,BMP7,C1QTNF12,Ca2+,captopril,carbon tetrachloride,CAV3,CCR7,CD19,CD2AP,CHRM1,CHRM2,cocaine,CX3CL1,daunorubicin,deferoxamine,deoxycholate,Dynamin,eflornithine,Fc gamma receptor,fluvoxamine,G protein beta gamma,GAST,GLRX2,GRN,Hsp90,hydrogen sulfide,ibutamoren,INS,IRS,KIT,KLRC4-KLRK1/KLRK1,L-triiodothyronine,lactacystin,leucine,Li+,LIF,liraglutide,LPAR1,LRP8,LRRK2,MAGI3,MAP2K2,MAP3K7,MAPK7,MCTS1,miR-133a-3p (and other miRNAs w/seed UUGGUCC),MMP7,MRAS,Notch,NOX1,Nrg1,NRP2,NTRK1,oleic acid,p85 (pik3r),PDGF-AA,PDGFB,PDGFC,Pdpk,peroxynitrite,PGF,phosphatidylinositol,phosphatidylinositol 3,4-diphosphate,phospholipid,PIK3CD,PIK3CG,PLA2G6,PLAC8,PLCL1,PLD1,PPARD,PRG2,PRKAA1,PRNP,prostaglandin E2,Rab5,RAP1A,RASA1,RELN,RETN,RHOG,selenodiglutathione,SH3BP2,SLC30A7,SPHK1,SYNM,taurocholic acid,tauroursodeoxycholic acid,TRPC6,TRPM2,urea,VAV1,VEGFC,vildagliptin,WNT16,YES1,ZEB2 1,2-dioctanoyl-sn-glycerol,3',4',7-trihydroxyisoflavone,AR-12,AR-42,as-604850,beta-cyclodextrin,BRD7,bryostatin 1,caffeic acid phenethyl ester,canertinib,capivasertib,DAB2IP,deguelin,delta-tocopherol,DETA-NONOate,DOK1,DRD3,ENG,fatty acid,FGR,forskolin,G6PC3,gamma tocopherol,ganglioside GT1,GRK2,indomethacin,INPP4B,ipatasertib,JINK1/2,JMJD8,KN 93,KRT10,KT5823,LAX1,MAGI2,MEN1,MK2206,MME,nelfinavir,nifedipine,NOX3,O6-benzylguanine,PD173074,PDC,perifosine,phosphatase,phosphate,piceatannol,PIK3IP1,PPP1CA,prednisolone,PTPA,R59949,RBP1,RGS3,SCD,SOCS3,sodium azide,sorbitol,suramin,tanespimycin,tosylphenylalanyl chloromethyl ketone,tozasertib,TRIB2,Trolox C,TSC22D3,tunicamycin,vatalanib,YM-024,zoledronic acid CCND2,CCNE1,CISH,EP300,Focal adhesion kinase,Histone h2a,HMOX1,MAP3K11,MAP3K8,MDM2,MOSPD2,MSTN,N-cor,NFkB (complex),PEA15,RPS6KB1,RPS6KB2,SLC2A1,SLC5A5,TERT CASP3,caspase,FASLG,FOXO4,PPARA,RAC2 CLEC4A transmembrane receptor 2 -1.265 1.38E-02 4.12E-02 Akt,CLEC4A,ERK1/2 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (3) 2 IgG TIE1 kinase 0.606 2 1.265 1.38E-02 4.11E-02 Akt,ERK1/2,TIE1 AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (3) 2 ANGPT1,ANGPT4 FOXO4 salinosporamide A chemical drug 1 1.414 1.38E-02 1.48E-02 salinosporamide A BIRC2,BIRC3 2 (1) 1 CASP3 NFkB (complex),TRAF1 TRIB1 kinase 2 -1.000 1.38E-02 3.53E-02 ERK,ERK1/2,TRIB1 ACAA1,ADGRG6,ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,ITGB3 9 (3) 3 GW3965 MFN2,PIK3CD,RGL1,TFAM SCD SCGB3A1 cytokine 2 1.508 1.38E-02 4.98E-02 Akt,RB1,SCGB3A1 AIMP2,ANGPT2,BIRC2,CALCRL,CELSR1,H2BC21,L1CAM,MAPK4,PLG,RRM2,TNFSF14 11 (3) 2 ESR2 arformoterol chemical drug 2 -0.707 1.39E-02 3.52E-02 ADRB2,Akt,arformoterol AIMP2,ANGPT2,BIRC2,FASN,L1CAM,PLG,RRM2,TNFSF14 8 (3) 2 LM-1685 chemical reagent 2 -0.333 1.40E-02 4.30E-02 Akt,ERK,LM-1685 ADGRG6,AIMP2,BIRC2,CEBPD,ITGB3,L1CAM,PLG,RRM2,TNFSF14 9 (3) 2 SR 144528 chemical reagent 2 0.333 1.40E-02 3.81E-02 Akt,EIF4EBP1,MAPK3,p70 S6k,SR 144528 AIMP2,B4GALT1,BIRC2,CEBPD,FASN,L1CAM,PLG,RRM2,TNFSF14 9 (5) 4 Ca2+,leukotriene B4 4,5,6,7-tetrabromo-2-azabenzamidazole chemical - kinase inhibitor 2 -0.707 1.41E-02 3.28E-02 4,5,6,7-tetrabromo-2-azabenzamidazole,PGK1,SIRT1 BIRC3,CLEC10A,FASN,HCRTR2,IFI44,PLG,SOD3,TSG101 8 (3) 2 N-cor TBC1D3G (includes others) other 2 0.000 1.41E-02 3.91E-02 Akt,IRS1,p70 S6k,TBC1D3G (includes others) AIMP2,BIRC2,CEBPD,FASN,L1CAM,PLG,RRM2,TNFSF14 8 (4) 3 IRS1 Sapk group 2 Inhibited -2.309 1.42E-02 4.60E-02 Ap1,JUN,JUNB,MAP2K4,MAPK14,MAPK8,MAPK9,PRKRA,Sapk B4GALT1,BIRC3,CALM1 (includes others),CEBPD,DGAT1,ITGB3,LRP6,PLIN2,POLI,REG1A,RRM2,SOD3 12 (9) 8 anisomycin,ceramide,CRKL,deferoxamine,ERN1,etoposide,MAP3K11,MAP3K4,MAP3K7,MAP4K3,MAP4K4,NMDA Receptor,sorbitol,TAOK2 dorsomorphin,PIP5K1B ATF2,FASLG,MAPK8IP3 brinzolamide chemical drug 2 -1.732 1.43E-02 3.00E-02 brinzolamide,CA4,CA9 ANK1,PGK1,PNLIP 3 (3) 2 CA4 ethoxyzolamide chemical drug 2 -1.732 1.43E-02 3.00E-02 CA4,CA9,ethoxyzolamide ANK1,PGK1,PNLIP 3 (3) 2 CA4 methazolamide chemical drug 2 -1.732 1.43E-02 3.00E-02 CA4,CA9,methazolamide ANK1,PGK1,PNLIP 3 (3) 2 CA4 sulfacetamide chemical drug 2 -1.732 1.43E-02 3.00E-02 CA4,CA9,sulfacetamide ANK1,PGK1,PNLIP 3 (3) 2 CA4 FOXQ1 transcription regulator 2 1.342 1.43E-02 3.59E-02 ALDH1A1,FOXQ1,TWIST1 CELSR1,FASN,FAT4,FCGBP,ITGB3 5 (3) 2 WNT3A BCOR,CDX1,ESR2 Na+,K+ -ATPase complex 2 -0.707 1.43E-02 2.86E-02 ERK1/2,Jnk,Na+,K+ -ATPase,SRC (family) ANGPT2,AOC1,BIRC2,BIRC3,CD209,CLEC10A,ITGB3,PLG 8 (4) 3 arginine,Cofilin,forskolin,FSTL1,iloprost,INS,KT5823,L-triiodothyronine,LOC102724428/SIK1,PRKAA1,prostaglandin E2,sildenafil,triiodothyronine, reverse Ca2+,dorsomorphin,marinobufagenin,oleic acid,ouabain,phorbol-12,13-diacetate,prazosin,tacrolimus SEMA6A transmembrane receptor 2 -1.265 1.44E-02 3.88E-02 Akt,ERK1/2,KDR,SEMA6A AIMP2,ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (4) 3 SALL4 reserpine chemical drug 2 -0.816 1.45E-02 3.88E-02 ABCB4,NR1I2,reserpine CGAS,CYP39A1,FASN,GNAO1,GSTM3,HSD3B2 6 (3) 3 GNAI3 SLC6A3 costunolide chemical - endogenous non-mammalian 2 0.000 1.46E-02 4.21E-02 Akt,costunolide,FADD,Jnk,USP7 AIMP2,BIRC2,BIRC3,CD209,CLEC10A,ETNK1,L1CAM,PLIN2,RRM2,TNFSF14 10 (5) 4 CASP3 TERT SLC6A3 transporter 2 1.000 1.47E-02 4.29E-02 Akt,CDK5,MAPT,NTRK2,SLC6A3 AIMP2,ASPG,BIRC2,GLB1,L1CAM,PLG,RRM2,SNAP25,TNFSF14 9 (5) 4 8-bromo-cAMP,amodiaquine,forskolin,phosphate 6-hydroxydopamine,cocaine,DRD3,peroxynitrite,reserpine,vanoxerine histone deacetylase inhibitor chemical drug 2 -1.000 1.47E-02 3.80E-02 ERK1/2,Hdac,histone deacetylase inhibitor,TERT ANGPT2,AOC1,BIRC2,BIRC3,EMX2,GLB1,IFI44,ITGB3,LRP4 9 (4) 3 CASP3,FASLG TERT miltefosine chemical drug 2 0.333 1.47E-02 3.76E-02 Akt,Jnk,miltefosine ABCA3,AIMP2,BIRC2,BIRC3,CD209,CLEC10A,L1CAM,RRM2,TNFSF14 9 (3) 3 PLD1 paraquat chemical toxicant 1 -1.000 1.48E-02 2.82E-02 paraquat ANGPT2,CEBPD,LRP4,SOD3 4 (1) 1 CASP3,FASLG,HMOX1,NFkB (complex),SOD1,tyrosine kinase PIK3CA,SOD3 triacetyl-3-hydroxyphenyladenosine chemical reagent 3 0.333 1.49E-02 4.46E-02 ACHE,clopidogrel,MMP2,MMP9,MPO,NOS3,PON1,PRKAA2,SERPINE1,triacetyl-3-hydroxyphenyladenosine CHAC1,FASN,IFI44,ITGB3,L1CAM,NANOS1,PLG,SLC5A7,SOD3 9 (10) 7 SOS2 other 0.000 2 -0.632 1.49E-02 4.47E-02 Akt,ERK1/2,RAS,SOS2 AIMP2,ANGPT2,AOC1,B4GALT1,BIRC3,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (4) 3 PLD1 CASP3 kb-NB 142-70 chemical drug 2 -0.378 1.49E-02 3.39E-02 DUSP1,Jnk,kb-NB 142-70 BIRC3,CD209,CLEC10A,IFI44,PLG,PLIN2,PTPRK 7 (3) 2 ERN1,PRKD2,PRKD3 NRG (family) group 1 1.414 1.50E-02 2.66E-02 NRG (family) CHRNA10,CHRNB3 2 (1) 1 forskolin Ca2+,CAMK2,CHRNA4,Cofilin,Mapk kinase,MAPK7 SUPT20H other 0.000 1 1.414 1.50E-02 1.26E-02 SUPT20H BIRC3,TNFSF14 2 (1) 1 ICOS,MAP3K7 zerumbone chemical - endogenous non-mammalian 1 1.414 1.50E-02 1.59E-02 zerumbone BIRC2,BIRC3 2 (1) 1 CASP3,HMOX1 NFkB (complex),TRAF1 MDFIC other 2 0.816 1.50E-02 2.79E-02 MAPK8,MAPK9,MDFIC B4GALT1,BIRC3,DGAT1,FASN,PLIN2,SOD3 6 (3) 2 Mapk kinase group 2 -1.265 1.51E-02 4.12E-02 ERK1/2,Jnk,Mapk kinase,P38 MAPK ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 10 (4) 3 MAP3K7,NRG (family) HMOX1 enzyme 1 Inhibited -2.000 1.52E-02 2.27E-02 HMOX1 ANGPT2,ANGPTL3,ITGB3,TNFSF14 4 (1) 1 1,1,2,2-tetrachloroethane,3-hydroxyanthranilic acid,4-(2-aminoethyl)benzenesulfonylfluoride,AKT1,allyl isothiocyanate,arecoline,caffeic acid phenethyl ester,captopril,carbon tetrachloride,cerivastatin,CNTF,CX3CL1,deferoxamine,DETA-NONOate,diquat,ellagic acid,EP300,exemestane,fatty acid,FGF9,forskolin,gamma-linolenic acid,guanosine,HIPK2,HNF4A,hydrogen sulfide,indomethacin,KDM3A,lactacystin,linsidomine,MAP3K7,MAPK7,NCOA3,nelfinavir,paraquat,peptidoglycan,piceatannol,PIK3CG,PPARA,propofol,prostaglandin A1,prostaglandin A2,protocatechuic acid,protoporphyrin IX,quercetin,RETN,rhodioloside,S-adenosylmethionine,sanguinarine,sildenafil,suramin,tunicamycin,Z36,zerumbone 2-mercaptoethanol,25-hydroxycholesterol,3-methyladenine,CBLC,choline,CISH,IRS1,LY83583,mir-154,NOX1,oleic acid,PNPLA8,RXRA,SLC2A1,tiron,WNT5A,ziritaxestat ATR,PROCR ANGPT1,CASP3,CCNE1,CXCL10,CXCL9,DGCR8,IFNB1,mir-145,N,N-dimethylarginine,RELN,VEGFD ziritaxestat chemical drug 2 1.265 1.53E-02 4.42E-02 Akt,ERK,ziritaxestat ABCA3,ADGRG6,AIMP2,BIRC2,CEBPD,ITGB3,L1CAM,PLG,RRM2,TNFSF14 10 (3) 3 LPAR1 HMOX1,USP18 dATP chemical - endogenous mammalian 2 1.414 1.53E-02 3.75E-02 dATP,IKBKB,IKBKE,TBK1 BIRC2,BIRC3,CEBPD,IFI44,ITGB3,KRT8,PGK1,SOD3 8 (4) 3 RRM2 BI 836845,MK-8776,phenformin CASP3,caspase CYP27B1 enzyme -0.000 2 0.333 1.55E-02 4.15E-02 Akt,cholecalciferol,CYP27B1 AIMP2,BIRC2,CD209,CEBPD,CUBN,L1CAM,PLG,RRM2,TNFSF14 9 (3) 2 forskolin,MALP-2s infliximab,L-triiodothyronine,SOST Ca2+ CCL3L3,NFkB (complex) miR-182-5p (and other miRNAs w/seed UUGGCAA) mature microRNA 1 -1.732 1.55E-02 3.03E-02 miR-182-5p (and other miRNAs w/seed UUGGCAA) CASP2,LRP6,NLGN2 3 (1) 1 PPARA IFNB1,ITGA4,LRP6,MTSS1,NMI,PGF,PIK3CA,RPS6KB1 thiostrepton chemical - endogenous non-mammalian 2 -1.414 1.56E-02 2.78E-02 ERK1/2,FOXM1,thiostrepton ANGPT2,AOC1,BIRC2,BIRC3,GLB1,ITGB3,PGK1,RRM2 8 (3) 2 CDKN2A MDFI other 2 0.816 1.56E-02 2.72E-02 MAPK8,MAPK9,MDFI B4GALT1,BIRC3,DGAT1,FASN,PLIN2,SOD3 6 (3) 2 GDF2,MIR17HG,PPARD mrs2179 chemical reagent 2 1.265 1.56E-02 4.33E-02 ERK1/2,Jnk,mrs2179,P38 MAPK ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 10 (4) 3 IC87114 chemical drug 2 1.000 1.56E-02 4.61E-02 Akt,IC87114,p70 S6k,PIK3CG AIMP2,BIRC2,FASN,ITGB3,KRT8,L1CAM,PLG,RRM2,TNFSF14 9 (4) 3 PIK3CD,PIK3CG ATOX1 transporter 3 -0.707 1.58E-02 3.85E-02 Akt,ATOX1,ATP7B AIMP2,BIRC2,FASN,L1CAM,PLG,RRM2,SOD3,TNFSF14 8 (3) 3 HNF4A SOD3 RP1 other 2 -0.816 1.59E-02 3.00E-02 MAPK8,MAPK9,RP1 B4GALT1,BIRC3,DGAT1,FASN,PLIN2,SOD3 6 (3) 2 mir-488 microRNA 2 1.414 1.60E-02 2.93E-02 Jnk,mir-488,P38 MAPK ANK1,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG,PRKCSH 8 (3) 3 cocaine protocatechuic acid chemical - endogenous non-mammalian 2 -1.000 1.60E-02 4.85E-02 Akt,Jnk,protocatechuic acid AIMP2,BIRC2,BIRC3,CD209,CLEC10A,L1CAM,PLG,RRM2,TNFSF14 9 (3) 2 2-chloroadenosine HMOX1 iron GW3965 chemical reagent 1 1.000 1.61E-02 2.60E-02 GW3965 ANGPTL3,FASN,PLIN2,TNFSF14 4 (1) 1 LPIN1,MERTK,SCD,SOCS3 CIDEC,CXCL10,NR5A2,PPP1R15A,TRIB1 camptothecin chemical drug 1 -0.378 1.61E-02 3.47E-02 camptothecin BIRC2,BIRC3,CASP2,CHAC1,LITAF,PTPRK,RRM2 7 (1) 1 ATF3,ATR,BTG2,Ca2+,CASP3,caspase,CDKN2A,ceramide,CSNK1D,FASLG,HSPB1,KLHL21,MAP3K11,Map3k7,MDM2,NFkB (complex),PCGF1,RRM2,SAA1,SDC4,SIAH1,TACSTD2,TAP1,TRAF1,TSPYL2 IFNB1,ITSN1,LOC102724788/PRODH,PLD1 JNK inhibitor XIV chemical drug 2 0.816 1.62E-02 2.99E-02 JNK inhibitor XIV,MAPK8,MAPK9 B4GALT1,BIRC3,DGAT1,FASN,PLIN2,SOD3 6 (3) 2 MFAP2 other 2 -0.816 1.62E-02 3.10E-02 MFAP2,NOTCH1 BIRC2,BIRC3,ITGB3,KRT8,PGK1,PTPRK 6 (2) 2 epicatechin,MFAP5,SATB2 ITGA4 prednisolone chemical drug 1 0.000 1.62E-02 4.25E-02 prednisolone BIRC2,BIRC3,CASP2,CEBPD,PGK1,SOD3 6 (1) 1 CSNK1D,LOC102724428/SIK1,NFkB (complex),TSC22D3 AKT1,CDKN2A,CXCL10,FANCC,GABARAP,GABARAPL1,GABARAPL2,IFNB1,INS,Irgm1,ITGA4,NQO2,PIK3CG,PRKAA1,PRNP,prostaglandin E2,RPS6KB1,SOD1,SOD3 birabresib chemical drug 1 -1.732 1.62E-02 3.46E-02 birabresib H2BC21,IFI44,NANOS1 3 (1) 1 MFNG,NTRK1,USP18 ADAMTS13 peptidase 1 -1.000 1.63E-02 2.19E-02 ADAMTS13 ANGPT2 1 (1) 1 AJ5012 chemical reagent 1 1.000 1.63E-02 2.27E-02 AJ5012 FASN 1 (1) 1 BCAN other 0.000 1 -1.000 1.63E-02 1.35E-02 BCAN ITGB3 1 (1) 1 INHA CDH2 CCNDBP1 other -0.000 1 1.000 1.63E-02 1.34E-02 CCNDBP1 MKX 1 (1) 1 CHIR-124 chemical reagent 1 1.000 1.63E-02 2.21E-02 CHIR-124 RRM2 1 (1) 1 RRM2 CIDEB other 1 -1.000 1.63E-02 1.30E-02 CIDEB PLIN2 1 (1) 1 RAB2A POU5F1 fatty acid CK1 group 1 -1.000 1.63E-02 1.56E-02 CK1 BIRC2 1 (1) 1 FASLG,LRP6,PROS1 DDX41 enzyme -0.000 1 1.000 1.63E-02 3.44E-02 DDX41 CGAS 1 (1) 1 TERT NPY IFNB1 F5 other 1 1.000 1.63E-02 1.40E-02 F5 MMRN1 1 (1) 1 2-mercaptoethanol,Ca2+,PROS1,tacrolimus,TFPI HSD17B13 enzyme 1 -1.000 1.63E-02 2.27E-02 HSD17B13 FASN 1 (1) 1 IPP-204106N chemical drug 1 1.000 1.63E-02 2.10E-02 IPP-204106N ANGPT2 1 (1) 1 IRS group 1 1.000 1.63E-02 2.07E-02 IRS DGAT1 1 (1) 1 EXT1,INS,RETN AKT1 LILRB2 transmembrane receptor 1 -1.000 1.63E-02 3.50E-02 LILRB2 FASN 1 (1) 1 METTL5 enzyme 1 1.000 1.63E-02 2.27E-02 METTL5 CALM1 (includes others) 1 (1) 1 CALM1 (includes others) PS-K chemical drug 1 1.000 1.63E-02 1.56E-02 PS-K BIRC2 1 (1) 1 CASP3 NFkB (complex) RNF139 enzyme 0.000 1 -1.000 1.63E-02 2.27E-02 RNF139 FASN 1 (1) 1 SELENOH other 0.000 1 1.000 1.63E-02 2.49E-02 SELENOH GLB1 1 (1) 1 SENP5 peptidase 0.000 1 1.000 1.63E-02 1.56E-02 SENP5 BIRC2 1 (1) 1 SNF8 enzyme 0.000 1 -1.000 1.63E-02 8.70E-03 SNF8 VPS25 1 (1) 1 TAT enzyme -0.000 1 -1.000 1.63E-02 1.12E-02 TAT GLB1 1 (1) 1 ESR2,forskolin,HNF4A triiodothyronine, reverse NFkB (complex) TIMM50 phosphatase 0.000 1 1.000 1.63E-02 2.21E-02 TIMM50 HSD3B2 1 (1) 1 TRIM54 other 0.000 1 -1.000 1.63E-02 2.40E-02 TRIM54 FLNC 1 (1) 1 ZM 306416 chemical drug 1 1.000 1.63E-02 1.02E-02 ZM 306416 ANGPT2 1 (1) 1 clofazimine chemical drug 1 -1.000 1.63E-02 1.30E-02 clofazimine PLIN2 1 (1) 1 CASP3 desflurane chemical drug 1 -1.000 1.63E-02 1.56E-02 desflurane BIRC2 1 (1) 1 miltefosine chemical drug 1 -1.000 1.63E-02 2.45E-02 miltefosine ABCA3 1 (1) 1 PLD1 CA4 enzyme 1 1.414 1.63E-02 2.82E-02 CA4 ANK1,PNLIP 2 (1) 1 VEGFB brinzolamide,CISH,ethoxyzolamide,methazolamide,sulfacetamide HSD17B4 enzyme 0.000 1 0.000 1.63E-02 2.83E-02 HSD17B4 ACAA1,FASN 2 (1) 1 PPARA,RXRA ACSL1,FGF4,SCP2 UBA1 enzyme -0.000 1 1.414 1.63E-02 2.82E-02 UBA1 BIRC2,BIRC3 2 (1) 1 L-triiodothyronine,MLN7243 HSPB1 BANCR other 2 -1.667 1.64E-02 4.72E-02 BANCR,ERK,Jnk,Mek ADGRG6,BIRC3,CASP2,CD209,CEBPD,CLEC10A,FASN,ITGB3,PLG 9 (4) 3 SEMA7A transmembrane receptor 2 -0.333 1.64E-02 4.42E-02 Akt,ITGB1,SEMA7A AIMP2,BIRC2,ITGB3,L1CAM,LRP6,PLG,RRM2,TNFSF14,TNXB 9 (3) 2 DIO2,L-triiodothyronine DSCAM CCN5 KU-60019 chemical drug 2 1.897 1.65E-02 4.83E-02 ATM,JUN,KU-60019,MAPK8,SRC,STING1 B4GALT1,BIRC2,BIRC3,CGAS,DGAT1,GLB1,IFI44,PGK1,POLI,RRM2 10 (6) 6 ATF3 transcription regulator 1 0.000 1.65E-02 2.47E-02 ATF3 BIRC3,DUT,RAB11A,RRM2 4 (1) 1 (1S,2R)-NCL-1,2-mercaptoethanol,25-hydroxycholesterol,anisomycin,ATF2,BHLHE40,Ca2+,camptothecin,carbon tetrachloride,CNTF,cyclophosphamide,dalfampridine,etoposide,farnesol,forskolin,GnRH-A,lactacystin,mitomycin C,NCD-38,nelfinavir,NMDA Receptor,oblimersen,PGF,PRKAA1,taurocholic acid,TERT,tolfenamic acid,tunicamycin ERN1,leucine,miR-34a-5p (and other miRNAs w/seed GGCAGUG),RPL22,S100A9,SCD,SOCS3,VEGFB bile acid,CASP3,HSPB1,PENK,PPP1R15A,RRM2 CCNE1,CX3CL1 STRADB kinase 2 -0.816 1.67E-02 3.30E-02 MAPK8,MAPK9,STRADB B4GALT1,BIRC3,DGAT1,FASN,PLIN2,SOD3 6 (3) 2 SOX7 transcription regulator -0.000 1 0.577 1.68E-02 3.70E-02 SOX7 CALCRL,EMX2,LRP5 3 (1) 1 caspase,ENG,LRP5,TGFBI norfloxacin chemical drug 2 0.577 1.68E-02 3.35E-02 ACHE,CYP1A2,norfloxacin CACHD1,GSTM3,SLC5A7 3 (3) 2 ACHE (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester chemical reagent 2 0.707 1.69E-02 3.16E-02 (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester,ERK1/2,Jnk ANGPT2,AOC1,BIRC2,BIRC3,CD209,CLEC10A,ITGB3,PLG 8 (3) 2 CASP3,IL11,IL20 S-32826 chemical reagent 2 -0.707 1.69E-02 4.42E-02 Akt,LIPE,S-32826 AIMP2,BIRC2,FASN,L1CAM,PLG,PLIN2,RRM2,TNFSF14 8 (3) 2 iopanoic acid chemical drug 2 0.707 1.71E-02 4.53E-02 Akt,iopanoic acid,LIPE AIMP2,BIRC2,FASN,L1CAM,PLG,PLIN2,RRM2,TNFSF14 8 (3) 2 L-triiodothyronine polyphosphate 65 chemical reagent 2 0.333 1.73E-02 4.95E-02 Jnk,NFKBIA,polyphosphate 65 BIRC2,CD209,CEBPD,CLEC10A,KRT8,LITAF,NCAN,PLG,SOD3 9 (3) 2 Nrp-PlexinA complex 2 -1.134 1.74E-02 3.43E-02 CDK5,ERK1/2,Nrp-PlexinA,RAS ANGPT2,AOC1,B4GALT1,BIRC2,BIRC3,GLB1,ITGB3 7 (4) 3 KRT18 other 2 -1.000 1.75E-02 4.73E-02 Akt,Jnk,KRT18,KRT8 AIMP2,BIRC2,BIRC3,CD209,CLEC10A,L1CAM,REG1A,RRM2,TNFSF14 9 (4) 3 CCN5,INHA,NR5A2,PARPBP,PPP3CA,SFRP1,tanespimycin,TERT 8-bromo-cAMP,BHLHE40,Focal adhesion kinase,forskolin,HOXA10,IgG,LRP6,quercetin,RAD51C,ZEB2 physostigmine chemical drug 2 Inhibited -2.333 1.75E-02 3.91E-02 ACHE,ERK1/2,MMP2,P38 MAPK,physostigmine ANGPT2,ANK1,AOC1,BIRC2,BIRC3,CEBPD,ITGB3,PLG,SLC5A7 9 (5) 4 ACHE,CHRM1 swinholide A chemical toxicant 2 1.414 1.76E-02 3.05E-02 ERK1/2,MAPK14,swinholide A ANGPT2,AOC1,BIRC2,BIRC3,CEBPD,FASN,ITGB3,LRP6 8 (3) 2 ZBED6 transcription regulator 1 -1.414 1.76E-02 2.93E-02 ZBED6 ANKRD50,MB21D2 2 (1) 1 tosylphenylalanyl chloromethyl ketone chemical - protease inhibitor 1 1.414 1.76E-02 2.69E-02 tosylphenylalanyl chloromethyl ketone BIRC2,BIRC3 2 (1) 1 AKT1,ALDH3A1,CASP3,NFkB (complex),RPS6KB1 annexin A1 peptide (2-26) chemical reagent 2 -1.134 1.77E-02 4.01E-02 annexin A1 peptide (2-26),ERK,Jnk ADGRG6,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 7 (3) 2 apogossypolone chemical reagent 2 -1.134 1.77E-02 4.01E-02 apogossypolone,ERK,Jnk ADGRG6,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 7 (3) 2 schizandrin B chemical - endogenous non-mammalian 2 -0.447 1.81E-02 3.79E-02 NOS3,NR1I2,schizandrin B CYP39A1,FASN,GSTM3,HSD3B2,SOD3 5 (3) 2 HSH2D other 2 1.134 1.82E-02 4.31E-02 HSH2D,Jnk,P38 MAPK ANK1,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 7 (3) 2 CASP3 MARCHF2 enzyme 2 0.447 1.85E-02 4.01E-02 ADRB2,IKBKG,MARCHF2 ANGPT2,BIRC3,CEBPD,FASN,SOD3 5 (3) 2 CXCL10 desmethoxyyangonin chemical - endogenous non-mammalian 2 -0.447 1.85E-02 4.56E-02 CYP1A1,desmethoxyyangonin,NR1I2 CACHD1,CYP39A1,FASN,GSTM3,HSD3B2 5 (3) 2 MPZL1 other 2 1.134 1.88E-02 3.50E-02 ERK1/2,MPZL1,PTPN11 ABCA3,ANGPT2,AOC1,BIRC2,BIRC3,FASN,ITGB3 7 (3) 2 NET1 other -0.000 2 -0.378 1.88E-02 2.90E-02 Jnk,NET1,PAK2,PTK2,RHOB BIRC2,BIRC3,CD209,CLEC10A,ITGB3,PLG,WRN 7 (5) 4 PGR Notch,propofol PAK2 CDH2 SSTR5 G-protein coupled receptor 2 0.000 1.89E-02 2.98E-02 G protein alphai,Jnk,SSTR5 BIRC3,CD209,CEBPD,CLEC10A,FLNC,PLG 6 (3) 2 GRK2,INS,levothyroxine,thyroid hormone forskolin GABARAP transporter -0.000 2 -0.577 1.89E-02 3.42E-02 CASP1,GABARAP FASN,LGMN,SERINC2 3 (2) 2 CDKN2A,CNTF prednisolone OPRK1,PDGFB,PI4K2A USP19 peptidase -0.000 1 -1.414 1.90E-02 3.73E-02 USP19 BIRC2,BIRC3 2 (1) 1 ESR2 MAP3K7 CXCL10,Map3k7,NFkB (complex) miR-128-3p (and other miRNAs w/seed CACAGUG) mature microRNA 1 0.000 1.90E-02 2.86E-02 miR-128-3p (and other miRNAs w/seed CACAGUG) PTPRG,SNAP25 2 (1) 1 CDKN2A,FGR,GRM5,RELN scopolamine chemical drug 2 0.707 1.90E-02 4.77E-02 ACHE,Akt,scopolamine AIMP2,BCHE,BIRC2,L1CAM,PLG,RRM2,SLC5A7,TNFSF14 8 (3) 3 acetylcholine,ACHE CHRM1,CHRM2 miR-142-5p (and other miRNAs w/seed AUAAAGU) mature microRNA 2 1.414 1.93E-02 4.81E-02 Akt,miR-142-5p (and other miRNAs w/seed AUAAAGU),PI3K (family) AIMP2,BIRC2,BIRC3,FASN,L1CAM,PLG,RRM2,TNFSF14 8 (3) 2 HNF4A PELI2 enzyme 2 -1.134 1.93E-02 3.91E-02 ERK,Jnk,PELI2 ADGRG6,BIRC3,CD209,CEBPD,CLEC10A,ITGB3,PLG 7 (3) 2 Collagen type II complex 2 -1.134 1.96E-02 3.36E-02 Collagen type II,ERK1/2,MMP2 ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,PLG,TNFSF14 7 (3) 3 PTN,quercetin,SFRP1 indomethacin,lead CCL7,MAP3K8,MMP7 3-deazaneplanocin chemical drug 1 -0.577 1.97E-02 3.10E-02 3-deazaneplanocin AKNA,SLC5A7,SNX33 3 (1) 1 IFNB1,PPP1R15A,SELENOS,TSC22D3 NOX4 PND-1186 chemical drug 2 -0.447 1.97E-02 4.54E-02 AURK,Focal adhesion kinase,PND-1186,PTK2 ANK1,BIRC2,BIRC3,CSMD3,KRT8 5 (4) 3 Focal adhesion kinase Ecm group 2 -1.342 2.01E-02 3.11E-02 Ap1,Ecm,Focal adhesion kinase,PTK2 BIRC2,BIRC3,CALM1 (includes others),KRT8,RRM2 5 (4) 3 arginine BCAR1,Focal adhesion kinase PNPLA8 enzyme -0.000 2 -0.378 2.02E-02 3.80E-02 Jnk,MAPK9,PNPLA8 BIRC3,CD209,CLEC10A,DGAT1,FASN,PLG,SOD3 7 (3) 3 Ca2+ palmitoyl-coenzyme A 14,15-epoxyeicosatrienoic acid,leukotriene B4,prostaglandin E2 HMOX1 MFNG enzyme 2 1.633 2.02E-02 3.74E-02 MFNG,NOTCH1,NOTCH3 BIRC2,BIRC3,ITGB3,KRT8,PGK1,PTPRK 6 (3) 2 birabresib,HOXA10 JINK1/2 group 1 0.000 2.04E-02 1.63E-02 JINK1/2 FASN,PLG 2 (1) 1 allyl isothiocyanate,apicularen A,BDKRB2,bile acid,deferoxamine,deoxycholate,fatty acid,FGF19,FGFR4,iodine,MAP2K4/7,Map3k7,MAP3K7,oleic acid,SD-282 1'-acetoxychavicol acetate,DAB2,GPS2,teriflunomide,USP18 ATF2,CDH2,FASLG,IRS1,RXRA,SCD AKT1,HNF4A PD 123319 chemical drug 1 1.414 2.04E-02 3.93E-02 PD 123319 ANGPT2,FASN 2 (1) 1 NOX1 Ca2+,NFkB (complex) carbohydrate chemical - endogenous mammalian 1 -1.414 2.04E-02 2.56E-02 carbohydrate FASN,TKFC 2 (1) 1 SCD sucrose chemical - endogenous mammalian 1 -1.414 2.04E-02 2.51E-02 sucrose FASN,TKFC 2 (1) 1 ACSS2,Focal adhesion kinase,GPAM,PIP5K1B,SCD,TAS1R3 enoxacin chemical drug 2 1.732 2.04E-02 4.25E-02 CYP1A2,enoxacin CACHD1,GSTM3,ITGB3 3 (2) 2 L-glucose chemical - endogenous mammalian 2 -0.707 2.06E-02 4.36E-02 Jnk,L-glucose,MAPK14,MAPK9 BIRC3,CD209,CEBPD,CLEC10A,LRP6,PLG,PLIN2,SOD3 8 (4) 3 CRTC1 transcription regulator 2 -0.816 2.09E-02 3.22E-02 Ap1,CRTC1,Jnk BIRC3,CALM1 (includes others),CD209,CLEC10A,PLG,RRM2 6 (3) 2 forskolin Sik1 LOC102724428/SIK1 TJP1 other -0.000 2 0.816 2.09E-02 4.37E-02 Ap1,TJP1,TWIST1 CALM1 (includes others),CELSR1,FAT4,FCGBP,ITGB3,RRM2 6 (3) 2 4-phenylbutyric acid,ESR2,indomethacin,MK2206,MYZAP,NOX4,NPHS1,PF-573228,PPARA,PROCR,tacrolimus,WNT1,XDH forskolin,FZD8,mefunidone,mir-182,N,N-dimethylarginine,PF-3758309,PRKAA1,prostaglandin E2,SDCBP,tunicamycin tunicamycin chemical - endogenous non-mammalian 1 -0.816 2.09E-02 4.99E-02 tunicamycin BIRC2,BIRC3,CASP2,CHAC1,LRP6,PLIN2 6 (1) 1 ADAM10,ATF3,CASP3,CASR,ERN1,GRN,HMOX1,IFNB1,IRS1,NCOA3,Nrg1,PARP16,PPP1R15A,PRNP,SLC2A1,SYVN1,TRPC6 AKT1,C1QTNF12,Ca2+,DIO2,ganglioside,INS,L-triiodothyronine,LPIN1,LRP6,NFkB (complex),PHLPP1,PPARA,SOCS3,TJP1 25-hydroxycholesterol chemical reagent 1 0.577 2.12E-02 2.48E-02 25-hydroxycholesterol ANGPTL3,CHAC1,FASN 3 (1) 1 ATF3,sphingomyelin ACSL1,HMOX1,leukotriene B4,SCD doxycycline chemical drug 1 0.577 2.12E-02 3.66E-02 doxycycline CHAC1,L1CAM,TNFSF14 3 (1) 1 CASP3,FASLG,FGF7,HOXA10,MAP3K7,NFkB (complex),XDH EPAS1,Focal adhesion kinase,MMP7,SLC5A5 OSMR transmembrane receptor -0.000 1 0.000 2.18E-02 3.25E-02 OSMR BIRC3,FASN 2 (1) 1 CNTF SOCS3 IL31,SCD WIPF1 other 0.000 2 -1.134 2.30E-02 4.62E-02 Ap1,ITGB3,Jnk,WIPF1 BIRC2,BIRC3,CALM1 (includes others),CD209,CLEC10A,PLG,RRM2 7 (4) 3 GPS2 CD19,IgG GABARAPL2 other 0.000 1 -1.414 2.33E-02 3.79E-02 GABARAPL2 LGMN,SERINC2 2 (1) 1 prednisolone PDGFB,PI4K2A NR0B1 ligand-dependent nuclear receptor -0.000 1 0.000 2.33E-02 3.38E-02 NR0B1 FASN,HSD3B2 2 (1) 1 LOC102724428/SIK1,NCOA3,POU5F1 L-triiodothyronine,trabectedin ESR2,HNF4A,LHB,NR5A2,PGR trabectedin chemical drug 1 0.000 2.33E-02 4.01E-02 trabectedin LGMN,WRN 2 (1) 1 CASP3,CXCL10 NR0B1 TRA transmembrane receptor 2 -0.378 2.36E-02 4.07E-02 Jnk,MAPK14,TRA BIRC3,CD209,CEBPD,CLEC10A,FASN,LRP6,PLG 7 (3) 2 SYVN1 IgG SOCS3 CGB3 (includes others) other 2 -1.134 2.39E-02 4.21E-02 CGB3 (includes others),ERK1/2,FSHR,MMP2 ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,LGMN,PLG 7 (4) 3 8-bromo-cAMP,forskolin,GnRH-A SOD1 IL27 ESR2 ATOX1 transporter 1 1.000 2.43E-02 2.39E-02 ATOX1 SOD3 1 (1) 1 HNF4A SOD3 Ank2 other 1 -1.000 2.43E-02 3.44E-02 Ank2 L1CAM 1 (1) 1 Ca2+ BCLAF3 other 1 -1.000 2.43E-02 2.31E-02 BCLAF3 REG1A 1 (1) 1 IL11 FASTK kinase 1 -1.000 2.43E-02 1.56E-02 FASTK BIRC2 1 (1) 1 IBSP other 1 -1.000 2.43E-02 2.62E-02 IBSP ITGB3 1 (1) 1 BMP7,ESR2,NF-Y,phorbol 12,13-dibutyrate,prostaglandin E2 LIF,MSTN Ca2+ IRX1 transcription regulator 1 1.000 2.43E-02 3.04E-02 IRX1 H2BC21 1 (1) 1 BDKRB2,FGF7 MK-8776 chemical drug 1 1.000 2.43E-02 2.19E-02 MK-8776 RRM2 1 (1) 1 dATP,RRM2 PAGR1 other 1 -1.000 2.43E-02 2.60E-02 PAGR1 CEBPD 1 (1) 1 PBK kinase 1 -1.000 2.43E-02 2.52E-02 PBK BIRC3 1 (1) 1 Pick1 other 1 -1.000 2.43E-02 3.53E-02 Pick1 AIMP2 1 (1) 1 RAB3B enzyme 1 -1.000 2.43E-02 3.56E-02 RAB3B SNAP25 1 (1) 1 SRT2104 chemical drug 1 1.000 2.43E-02 3.80E-02 SRT2104 TSG101 1 (1) 1 CD63 VAMP7 transporter 0.000 1 -1.000 2.43E-02 2.20E-02 VAMP7 L1CAM 1 (1) 1 4-phenylbutyric acid,phytohemagglutinin,SYVN1 ixabepilone chemical drug 1 1.000 2.43E-02 3.85E-02 ixabepilone BIRC2 1 (1) 1 CASP3 tolylfluanid chemical toxicant 1 -1.000 2.43E-02 3.32E-02 tolylfluanid FASN 1 (1) 1 LPIN1,SCD GABARAP transporter -0.000 1 -1.414 2.48E-02 4.13E-02 GABARAP LGMN,SERINC2 2 (1) 1 CDKN2A,CNTF prednisolone OPRK1,PDGFB,PI4K2A GABARAPL1 other 1 -1.414 2.48E-02 4.13E-02 GABARAPL1 LGMN,SERINC2 2 (1) 1 FOXO4 INS,prednisolone OPRK1,PDGFB,PI4K2A NADH chemical - endogenous mammalian 2 0.000 2.49E-02 4.85E-02 CYP1A2,NADH,SPHK1 BIRC2,BIRC3,CACHD1,GSTM3 4 (3) 2 ouabain quercetin SPHK1,XDH benserazide chemical drug 2 -0.378 2.56E-02 4.68E-02 benserazide,ERK1/2,TPH1 ANGPT2,AOC1,BIRC2,BIRC3,ITGB3,LGMN,RRM2 7 (3) 2 SLC5A5 transporter 0.000 2 -0.577 2.61E-02 3.69E-02 LIPE,SLC5A5 ABCA3,FASN,PLIN2 3 (2) 2 AKT1,forskolin,quercetin ceramide,deferoxamine,doxycycline,iodine,PTTG1 DIO1,L-triiodothyronine MIR17-92 group 2 1.000 2.61E-02 3.56E-02 mir-17,mir-25,MIR17-92 BIRC2,BIRC3,ITGB3,LRP6 4 (3) 3 FZD4,LRP6 carmustine chemical drug 2 -0.378 2.63E-02 4.78E-02 carmustine,MAPK14,MAPK8,NOS3 B4GALT1,BIRC3,CEBPD,DGAT1,FASN,LRP6,SOD3 7 (4) 3 FASLG,Hsp90 SOST other 1 0.000 2.64E-02 2.70E-02 SOST FASN,PLIN2 2 (1) 1 deferoxamine,ESR2 CCL3L3,fatty acid,NOX4,SOD1 ACADS,CYP27B1,PPARA KLHL21 enzyme -0.000 2 0.816 2.66E-02 4.71E-02 AURKB,IKBKB,KLHL21 ANK1,BIRC3,CEBPD,ITGB3,KRT8,SOD3 6 (3) 2 camptothecin PTTG1 transcription regulator 1 -0.577 2.70E-02 3.61E-02 PTTG1 CEBPD,POLI,WRN 3 (1) 1 8-bromo-cAMP,Ca2+,CASR,FGF4 ANAPC11,ANAPC2,cytochalasin B,L-triiodothyronine,UBE2C CDH2,IgG,MDM2 RAD51C,SLC5A5 IL20 cytokine 1 1.414 2.80E-02 4.34E-02 IL20 FGL1,PLG 2 (1) 1 8-bromo-cAMP,CDKN2A,ESR2 (S,R)-3-(4-hydroxyphenyl)-4,5-dihydro-5-isoxazole acetic acid, methyl ester GSTA1,NPY,TNFRSF11A bryostatin 1 chemical drug 1 -1.414 2.80E-02 2.48E-02 bryostatin 1 BIRC3,CD209 2 (1) 1 CASP3,TRAF1 AKT1 ACHE enzyme -0.000 2 -0.447 2.83E-02 3.91E-02 ACHE,Gsk3,MAPT,PRKCE ASPG,BIRC3,CHRNB3,FASN,SLC5A7 5 (4) 4 D-galactose,EP300,etoposide,L-triiodothyronine,NTRK1,pralidoxime,scopolamine,tetracaine amitriptyline,carbon tetrachloride,CNTF,cryptotanshinone,cyclophosphamide,galanthamine,gallamine triethiodide,glycopyrrolate,huperzine A,irinotecan,norfloxacin,physostigmine,pilocarpine,quercetin,quinalphos,quinidine,rivastigmine,zinc chloride CASP3,CHRM2 acetylcholine PARPBP other 2 -1.000 2.87E-02 3.89E-02 PARPBP,STAT5A BIRC3,CASP2,HSD3B2,KRT8 4 (2) 2 KRT18 prolyl hydroxylase group 2 -0.577 2.87E-02 4.55E-02 EGLN1,EGLN3,prolyl hydroxylase ANGPT2,FASN,PGK1 3 (3) 2 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine chemical reagent 1 -1.414 3.14E-02 4.34E-02 1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine BIRC2,BIRC3 2 (1) 1 CASP3,PPARA N-cor group 1 0.000 3.14E-02 3.47E-02 N-cor FASN,PLIN2 2 (1) 1 AKT1,CNTF 4,5,6,7-tetrabromo-2-azabenzamidazole INPP4B ACSL1,CIDEC,PPARA,PPARD,SCD piceatannol chemical - endogenous non-mammalian 1 1.414 3.14E-02 2.84E-02 piceatannol ANGPT2,BIRC3 2 (1) 1 ATF2,CASP3,CDKN2A,HMOX1 AKT1,CCND2,MAP3K8,NFkB (complex),RPS6KB1 NCOA3 transcription regulator 0.000 1 0.577 3.15E-02 4.67E-02 NCOA3 FASN,PGK1,PLIN2 3 (1) 1 CDK4/6,CSNK1D,ERN1,ESR2,tunicamycin 4-methyl umbelliferone-8-carbaldehyde Ahr-aryl hydrocarbon-Arnt,CCNE1,ETV1,FGF4,Focal adhesion kinase,HMOX1,IRS1,LHB,NR0B1,NR5A2,PGR,RPS6KB1,SALL4,SLC2A1,XDH PPARD 4beta-hydroxycholesterol chemical - endogenous mammalian 1 -1.000 3.23E-02 3.32E-02 4beta-hydroxycholesterol FASN 1 (1) 1 LPIN1,SCD APPL1 other -0.000 1 -1.000 3.23E-02 3.37E-02 APPL1 SNAP25 1 (1) 1 CASP3,VAMP2 ASCC1 transcription regulator -0.000 1 1.000 3.23E-02 1.56E-02 ASCC1 BIRC2 1 (1) 1 6-hydroxydopamine NFkB (complex) Arg-Gly-Asp chemical reagent 1 1.000 3.23E-02 2.62E-02 Arg-Gly-Asp ITGB3 1 (1) 1 CASP3 Focal adhesion kinase CCDC3 other 1 -1.000 3.23E-02 4.54E-02 CCDC3 FASN 1 (1) 1 CTNNAL1 other 0.000 1 -1.000 3.23E-02 4.94E-02 CTNNAL1 ITGB3 1 (1) 1 Mt3 other 1 1.000 3.23E-02 4.98E-02 Mt3 CEBPD 1 (1) 1 HNF4A SIRT group 1 1.000 3.23E-02 2.27E-02 SIRT FASN 1 (1) 1 SCD SRT2183 chemical reagent 1 1.000 3.23E-02 3.23E-02 SRT2183 FASN 1 (1) 1 USP27X peptidase 1 1.000 3.23E-02 4.08E-02 USP27X CGAS 1 (1) 1 IFNB1 beta,beta-dimethylacrylshikonin chemical reagent 1 1.000 3.23E-02 2.60E-02 beta,beta-dimethylacrylshikonin BIRC3 1 (1) 1 hemicholinium 3 chemical reagent 1 -1.000 3.23E-02 1.29E-02 hemicholinium 3 SLC5A7 1 (1) 1 triacsin C chemical reagent 1 -1.000 3.23E-02 1.30E-02 triacsin C PLIN2 1 (1) 1 ACSL1 lith-O-Asp chemical reagent 2 1.732 3.25E-02 3.84E-02 lith-O-Asp,Ras homolog,ST6GAL1 BIRC3,ITGB3,PGK1 3 (3) 3 Cofilin,HSPB1 22(R)-hydroxycholesterol chemical - endogenous mammalian 1 0.000 3.67E-02 4.96E-02 22(R)-hydroxycholesterol ANGPTL3,FASN 2 (1) 1 HAS2 Secretase gamma DASA-58 chemical reagent 1 -1.000 4.02E-02 4.60E-02 DASA-58 FASN 1 (1) 1 LHB other 1 1.000 4.02E-02 4.59E-02 LHB HSD3B2 1 (1) 1 Ca2+,EP300,fatty acid,forskolin,GnRH-A,NCOA3,NR5A2,oleic acid,PD173074 dorsomorphin,ESR2,Inhibin,KN 93,levothyroxine,NR0B1,PEA15,PGR NFkB (complex) Mamld1 other 1 1.000 4.02E-02 4.52E-02 Mamld1 HSD3B2 1 (1) 1 RAD51C enzyme -0.000 1 1.000 4.02E-02 4.98E-02 RAD51C KRT8 1 (1) 1 PTTG1 KRT18,PGR butylphen chemical toxicant 1 -1.000 4.02E-02 4.82E-02 butylphen RSL24D1 1 (1) 1 saxagliptin chemical drug 1 -1.000 4.02E-02 4.74E-02 saxagliptin TRAF3IP2 1 (1) 1 LG100268 chemical reagent 1 1.414 4.23E-02 4.69E-02 LG100268 BIRC2,PLIN2 2 (1) 1 IRS1,RXRA,SCD FASLG,L-triiodothyronine,levothyroxine,NFkB (complex) GPAM enzyme -0.000 1 1.000 4.80E-02 3.50E-02 GPAM PLIN2 1 (1) 1 ACSS2,fatty acid,GPAT3,PTN,STK24,sucrose PPARD,PRKAA1 NFkB (complex) SDC4 other 1 -1.000 4.80E-02 3.71E-02 SDC4 ANGPT2 1 (1) 1 BHLHE40,camptothecin,CCN5,ESR2,NFkB (complex),WNT3A,ZFTA-RELA WNT5A Focal adhesion kinase ATF2 SENP6 peptidase -0.000 1 1.000 4.80E-02 3.92E-02 SENP6 BIRC2 1 (1) 1 NFkB (complex) SLC39A14 transporter -0.000 1 1.000 4.80E-02 4.63E-02 SLC39A14 FASN 1 (1) 1 SCD mir-488 microRNA 1 1.000 4.80E-02 2.27E-02 mir-488 PRKCSH 1 (1) 1 cocaine vaccenic acid chemical - endogenous mammalian 1 1.000 4.80E-02 4.48E-02 vaccenic acid PLIN2 1 (1) 1 glyceraldehyde-BSA chemical reagent 1 -1.000 5.58E-02 4.77E-02 glyceraldehyde-BSA FASN 1 (1) 1 methylglyoxal-BSA chemical reagent 1 -1.000 5.58E-02 4.77E-02 methylglyoxal-BSA FASN 1 (1) 1 APBA3 transporter 1 1.000 6.35E-02 3.75E-02 APBA3 PGK1 1 (1) 1 SLC2A1 HTRA1 peptidase 0.000 1 1.000 6.35E-02 4.66E-02 HTRA1 NCAN 1 (1) 1 GDF2,NR5A2 NQO2 enzyme 1 -1.000 7.88E-02 2.87E-02 NQO2 BIRC2 1 (1) 1 PGR benzo(a)pyrene,prednisolone,quercetin NFkB (complex) Diseases and Bio Functions for My Projects->Mac - Oyster RNA-Seq->20220810_NOPP-gigas-ploidy-temp_pval_only 10:49 AM->desiccation_ploidy Categories Functions Diseases or Functions Annotation p-Value Predicted Activation State Activation z-score Notes Bias-corrected z-score Molecules # Molecules Cancer, Organismal Injury and Abnormalities head and neck cancer Head and neck cancer 5.04E-12 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,MMRN2,MMRN1,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,AIMP2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,PGBD4,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,IFI44,KIFC1,TMEM161B,SLC16A4,POU3F3 159 Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities epithelial thyroid cancer Thyroid carcinoma 7.32E-12 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,MMRN2,MMRN1,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,IFI44,KIFC1,TMEM161B,POU3F3 150 Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities nonpituitary endocrine tumor Nonpituitary endocrine tumor 8.59E-12 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,MMRN2,MMRN1,BIRC2,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,IFI44,KIFC1,TMEM161B,POU3F3 152 Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities endocrine gland tumor Endocrine gland tumor 1.44E-11 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,MMRN2,MMRN1,BIRC2,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,CLPB,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,DUT,IFI44,KIFC1,TMEM161B,POU3F3 155 Cancer, Organismal Injury and Abnormalities head and neck neoplasia Head and neck tumor 1.83E-11 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,AIMP2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,PGBD4,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,ALDH7A1,XPO7,GSTM3,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,DUT,IFI44,KIFC1,TMEM161B,SLC16A4,POU3F3 164 Cancer, Organismal Injury and Abnormalities tumorigenesis Tumorigenesis of epithelial neoplasm 2.62E-11 0.283 0.226 KRT8,CELSR1,LGMN,CHRNA10,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,PTK7,CHAC1,NLGN2,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,MEGF10,CSRNP3,FRRS1,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,HCRTR2,VWDE,PTGIR,RABL2B,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,KMT5A,ACAA1,WRN,FAT4,DUT,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 148 Cancer, Organismal Injury and Abnormalities intraabdominal organ tumor Intraabdominal organ tumor 2.80E-11 -0.923 -0.976 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,RABL2B,VPS25,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,DUT,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 170 Cancer, Organismal Injury and Abnormalities head and neck carcinoma Head and neck carcinoma 3.91E-11 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,MMRN2,MMRN1,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,PGBD4,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,IFI44,KIFC1,TMEM161B,POU3F3 154 Cancer, Organismal Injury and Abnormalities formation Formation of solid tumor 4.64E-11 -0.114 -0.165 KRT8,CELSR1,LGMN,CHRNA10,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,AIMP2,FLNC,SLC5A7,CYP39A1,HCRTR2,VWDE,PTGIR,RABL2B,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,DUT,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 162 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities intestinal adenocarcinoma Intestinal adenocarcinoma 5.01E-11 KRT8,CELSR1,CHRNA10,DGAT1,TRIM3,GLB1,BIRC3,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,HDHD5,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,PGBD4,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,XPO7,CLPB,TULP4,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ABCA5,MFSD1,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PRKCSH,FAT4,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 146 Cancer, Organismal Injury and Abnormalities abdominal neoplasm Abdominal neoplasm 5.19E-11 -0.923 -0.959 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,RABL2B,VPS25,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,DUT,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 171 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities gastrointestinal adenocarcinoma Gastrointestinal adenocarcinoma 6.31E-11 KRT8,CELSR1,CHRNA10,DGAT1,TRIM3,GLB1,BIRC3,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,HDHD5,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,XPO7,CLPB,TULP4,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ABCA5,MFSD1,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PRKCSH,FAT4,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 149 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities intestinal tumor Intestinal tumor 7.35E-11 KRT8,CELSR1,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,PGBD4,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,XPO7,CLPB,TULP4,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,RAB11A,ABCA5,MFSD1,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PRKCSH,FAT4,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 151 Cancer, Organismal Injury and Abnormalities frequency Frequency of tumor 7.36E-11 -0.114 -0.168 KRT8,CELSR1,LGMN,CHRNA10,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,PTK7,CHAC1,NLGN2,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,MEGF10,CSRNP3,FRRS1,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,HCRTR2,VWDE,PTGIR,RABL2B,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,KMT5A,ACAA1,WRN,FAT4,DUT,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 148 Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities endocrine carcinoma Endocrine carcinoma 1.06E-10 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,MMRN2,MMRN1,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,CLPB,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,IFI44,KIFC1,TMEM161B,POU3F3 152 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities large intestine adenocarcinoma Large intestine adenocarcinoma 1.36E-10 KRT8,CELSR1,CHRNA10,DGAT1,TRIM3,GLB1,BIRC3,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,HDHD5,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,PGBD4,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,XPO7,CLPB,TULP4,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ABCA5,MFSD1,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,TNFSF14,ANK1,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PRKCSH,FAT4,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 145 Cancer, Organismal Injury and Abnormalities incidence Incidence of tumor 1.62E-10 -0.268 -0.324 KRT8,CELSR1,LGMN,CHRNA10,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,PTK7,CHAC1,NLGN2,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,MEGF10,CSRNP3,FRRS1,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,HCRTR2,VWDE,PTGIR,RABL2B,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,KMT5A,ACAA1,WRN,PIF1,FAT4,DUT,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 150 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities neoplasia Gastrointestinal tumor 3.75E-10 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,XPO7,CLPB,TULP4,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PRKCSH,FAT4,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 156 Cancer, Organismal Injury and Abnormalities generation Generation of tumor 4.88E-10 KRT8,CELSR1,LGMN,CHRNA10,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,AIMP2,FLNC,SLC5A7,CYP39A1,HCRTR2,VWDE,PTGIR,RABL2B,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,ABCA5,MFSD1,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 158 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities large intestine neoplasm Large intestine neoplasm 5.59E-10 KRT8,CELSR1,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,HDHD5,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,PGBD4,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,XPO7,CLPB,TULP4,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ABCA5,MFSD1,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PRKCSH,FAT4,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 149 Cancer, Organismal Injury and Abnormalities development Development of carcinoma 8.01E-10 KRT8,CELSR1,LGMN,CHRNA10,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,PTK7,CHAC1,NLGN2,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,MEGF10,CSRNP3,FRRS1,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,HCRTR2,VWDE,PTGIR,RABL2B,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,ABCA5,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,KMT5A,ACAA1,WRN,FAT4,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 144 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities malignant neoplasm of large intestine Malignant neoplasm of large intestine 1.12E-09 KRT8,CELSR1,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,HDHD5,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,PGBD4,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,XPO7,CLPB,TULP4,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ABCA5,MFSD1,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,TNFSF14,ANK1,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PRKCSH,FAT4,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 148 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities gastrointestinal carcinoma Gastrointestinal carcinoma 1.21E-09 KRT8,CELSR1,LGMN,CHRNA10,DGAT1,TRIM3,GLB1,BIRC3,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,HDHD5,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,XPO7,CLPB,TULP4,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,ABCA5,MFSD1,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PRKCSH,FAT4,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 151 Cancer, Organismal Injury and Abnormalities abdominal adenocarcinoma Abdominal adenocarcinoma 2.16E-09 KRT8,CELSR1,LGMN,CHRNA10,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,PTGIR,RABL2B,VPS25,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PRKCSH,FAT4,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 159 Cancer, Organismal Injury and Abnormalities non-hematological solid tumor Non-hematological solid tumor 2.73E-09 -0.743 -0.767 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,AIMP2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,RABL2B,VPS25,PGBD4,DDO,ARL6IP4,RNF207,CALML3,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,DUT,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 174 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities digestive organ tumor Digestive organ tumor 2.82E-09 -0.728 -0.769 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,CLPB,TULP4,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PRKCSH,FAT4,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 163 Cancer, Organismal Injury and Abnormalities malignant solid organ tumor Malignant solid organ tumor 3.95E-09 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,C1QTNF3,REG1A,ITIH6,PDZD7,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,TTC24,L1CAM,TSPEAR,SCARF2,SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,PTGIR,PGBD4,DDO,CALML3,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,CLPB,TULP4,ANGPTL3,FCGBP,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,ANKRD50,NUBP1,DPY19L3,ZSWIM9,ABCA5,MFSD1,ZMYM1,CSMD3,TRIM2,PGK1,ITGB3,RRP36,MEGF11,TRIM36,COLEC11,SUSD2,CACHD1,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,FAT4,IFI44,THAP2,KIFC1,POU3F3 138 Cancer, Organismal Injury and Abnormalities extracranial solid tumor Extracranial solid tumor 4.37E-09 0.063 0.063 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,AIMP2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,RABL2B,VPS25,PGBD4,DDO,ARL6IP4,RNF207,CALML3,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,H2BC21,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,DUT,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 175 Cancer, Organismal Injury and Abnormalities cancer Cancer of secretory structure 5.21E-09 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,MMRN2,MMRN1,BIRC2,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,RRP12,C1QTNF4,NUBP1,HNRNPM,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,IFI44,KIFC1,TMEM161B,SLC16A4,POU3F3 154 Cancer, Organismal Injury and Abnormalities non-melanoma solid tumor Non-melanoma solid tumor 6.33E-09 -0.621 -0.658 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,AIMP2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,RABL2B,VPS25,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,DUT,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 173 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities hepato-pancreato-biliary cancer Hepato-pancreato-biliary cancer 6.76E-09 -1.982 -2.033 CELSR1,KRT8,LGMN,CHRNA10,SULT1A2,TRIM3,GLB1,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,PDZD7,CACFD1,TPPP3,PTK7,NLGN2,AGA,PTPRG,TNXB,HSD3B2,THSD4,RASEF,CR1,TTC24,L1CAM,SCARF2,TSPEAR,SNAP25,GNAO1,EMX2,FASN,HARBI1,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,DDX20,CSRNP3,FRRS1,LRP4,TENM3,BCHE,PLIN2,POLI,TRIM56,MB21D2,MMRN2,MMRN1,BIRC2,HDHD5,LRP5,L3HYPDH,TMPRSS6,PLG,AKNA,TNR,RRM2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,DDO,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,TULP4,SOD3,CCDC13,ABCA3,NCAN,RRP12,ANKRD50,HNRNPM,ZSWIM9,ABCA5,ZMYM1,CSMD3,FUT6,TRIM2,PGK1,ITGB3,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,PPP1CA,ACAA1,KMT5A,WRN,PRKCSH,FAT4,KIFC1,TMEM161B,SLC16A4 113 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities gastrointestinal tract cancer Gastrointestinal tract cancer 7.07E-09 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,HDHD5,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,XPO7,CLPB,TULP4,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,ABCA5,MFSD1,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PRKCSH,FAT4,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 153 Cancer, Organismal Injury and Abnormalities nonhematologic malignant neoplasm Nonhematologic malignant neoplasm 7.45E-09 -1.387 -1.401 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,AIMP2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,RABL2B,VPS25,PGBD4,DDO,ARL6IP4,RNF207,CALML3,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 173 Cancer, Organismal Injury and Abnormalities adenocarcinoma Adenocarcinoma 8.28E-09 KRT8,CELSR1,LGMN,CHRNA10,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,PTGIR,RABL2B,VPS25,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PRKCSH,FAT4,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 160 Cancer, Organismal Injury and Abnormalities soft tissue neoplasm Soft tissue neoplasm 1.06E-08 KRT8,CELSR1,SULT1A2,TRIM3,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,C1QTNF3,REG1A,ITIH6,PDZD7,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,TTC24,L1CAM,TSPEAR,SCARF2,SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,LRP4,MEGF6,TENM3,ATL2,BCHE,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,RABL2B,PGBD4,DDO,CALML3,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,CLPB,TULP4,ANGPTL3,FCGBP,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,NUBP1,DPY19L3,ZSWIM9,ABCA5,MFSD1,ZMYM1,CSMD3,TRIM2,PGK1,ITGB3,RRP36,MEGF11,TRIM36,COLEC11,SUSD2,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,FAT4,THAP2,KIFC1,POU3F3 133 Cancer, Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities hepatobiliary system cancer Hepatobiliary system cancer 1.07E-08 -1.982 -2.044 CELSR1,KRT8,LGMN,CHRNA10,SULT1A2,GLB1,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,CACFD1,NLGN2,AGA,PTPRG,TNXB,HSD3B2,THSD4,RASEF,CR1,TTC24,L1CAM,SCARF2,TSPEAR,SNAP25,GNAO1,FASN,HARBI1,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,DDX20,CSRNP3,LRP4,TENM3,BCHE,PLIN2,POLI,MB21D2,MMRN2,MMRN1,BIRC2,HDHD5,LRP5,L3HYPDH,TMPRSS6,PLG,AKNA,TNR,RRM2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,DDO,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,TULP4,SOD3,CCDC13,ABCA3,NCAN,ANKRD50,HNRNPM,ZSWIM9,ABCA5,ZMYM1,CSMD3,FUT6,TRIM2,PGK1,CASP2,TRIM36,SUSD2,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,ACAA1,KMT5A,PRKCSH,FAT4,KIFC1,TMEM161B 99 Cancer, Organismal Injury and Abnormalities malignant connective or soft tissue neoplasm Malignant connective or soft tissue neoplasm 1.14E-08 KRT8,CELSR1,SULT1A2,TRIM3,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,C1QTNF3,REG1A,ITIH6,PDZD7,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,TTC24,L1CAM,TSPEAR,SCARF2,SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,LRP4,MEGF6,TENM3,ATL2,BCHE,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,RABL2B,PGBD4,DDO,CALML3,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,NUBP1,DPY19L3,ZSWIM9,ABCA5,MFSD1,ZMYM1,CSMD3,TRIM2,PGK1,ITGB3,RRP36,MEGF11,TRIM36,COLEC11,SUSD2,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,FAT4,THAP2,KIFC1,POU3F3 134 Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities liver lesion Liver lesion 1.21E-08 -0.282 -0.370 CELSR1,KRT8,LGMN,CHRNA10,SULT1A2,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,C1QTNF3,CACFD1,NLGN2,AGA,PTPRG,TNXB,HSD3B2,THSD4,RASEF,CR1,TTC24,L1CAM,SCARF2,TSPEAR,GNAO1,FASN,HARBI1,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,CALCRL,DDX20,CSRNP3,LRP4,TENM3,ATL2,BCHE,PLIN2,POLI,MB21D2,MMRN2,MMRN1,BIRC2,HDHD5,LRP5,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,SYCE2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,DDO,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,TULP4,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,ANKRD50,HNRNPM,ZSWIM9,ABCA5,ZMYM1,CSMD3,FUT6,TRIM2,PGK1,ITGB3,MEGF11,CASP2,TRIM36,SUSD2,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,ACAA1,KMT5A,WRN,PRKCSH,FAT4,KIFC1 106 Cancer, Organismal Injury and Abnormalities abdominal carcinoma Abdominal carcinoma 1.35E-08 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,RABL2B,VPS25,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PRKCSH,FAT4,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 163 Cancer, Organismal Injury and Abnormalities abdominal cancer Abdominal cancer 1.46E-08 -1.387 -1.423 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,RABL2B,VPS25,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 166 Cancer, Organismal Injury and Abnormalities neoplasia Epithelial neoplasm 2.07E-08 -0.577 -0.618 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,RABL2B,VPS25,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,DUT,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 171 Dermatological Diseases and Conditions, Organismal Injury and Abnormalities skin lesion Skin lesion 2.14E-08 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,C1QTNF3,REG1A,ITIH6,PDZD7,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,TTC24,L1CAM,TSPEAR,SCARF2,SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,PTGIR,PGBD4,DDO,CALML3,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,CLPB,TULP4,ANGPTL3,FCGBP,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,ANKRD50,NUBP1,DPY19L3,ZSWIM9,ABCA5,MFSD1,ZMYM1,CSMD3,TRIM2,PGK1,ITGB3,MEGF11,TRIM36,COLEC11,SUSD2,CACHD1,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,ACAA1,WRN,PIF1,FAT4,IFI44,THAP2,KIFC1,POU3F3 136 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities hepatobiliary carcinoma Hepatobiliary carcinoma 2.22E-08 BIRC2,HDHD5,CELSR1,KRT8,LRP5,L3HYPDH,LGMN,CHRNA10,SULT1A2,TMPRSS6,GLB1,PLG,SLC16A14,AOC1,AKNA,TNR,RRM2,TRPM2,TKFC,PNLIP,FGL1,FLNC,SLC5A7,CYP39A1,LRP6,ADRM1,HCRTR2,VWDE,SNX33,HSPA12B,C1QTNF3,DDO,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,CACFD1,TULP4,NLGN2,SOD3,AGA,CCDC13,PTPRG,ABCA3,TNXB,NCAN,ANKRD50,HNRNPM,HSD3B2,THSD4,RASEF,CR1,TTC24,L1CAM,SCARF2,TSPEAR,ZSWIM9,SNAP25,GNAO1,ABCA5,ZMYM1,FASN,HARBI1,CSMD3,PKD1L2,SERINC2,MAPK4,CALCRL,FUT6,TRIM2,PGK1,DDX20,CASP2,TRIM36,CSRNP3,SUSD2,LRP4,CACHD1,TENM3,TSNARE1,CUBN,ANK1,BCHE,ACAA1,KMT5A,POLI,MB21D2,PRKCSH,FAT4,MMRN2,KIFC1,MMRN1,TMEM161B 96 Cancer, Organismal Injury and Abnormalities malignant soft tissue neoplasm Malignant soft tissue neoplasm 2.27E-08 KRT8,CELSR1,SULT1A2,TRIM3,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,C1QTNF3,REG1A,ITIH6,PDZD7,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,TTC24,L1CAM,TSPEAR,SCARF2,SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,LRP4,MEGF6,TENM3,ATL2,BCHE,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,RABL2B,PGBD4,DDO,CALML3,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,CLPB,TULP4,ANGPTL3,FCGBP,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,NUBP1,DPY19L3,ZSWIM9,ABCA5,MFSD1,ZMYM1,CSMD3,TRIM2,PGK1,ITGB3,RRP36,MEGF11,TRIM36,COLEC11,SUSD2,CACHD1,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,FAT4,THAP2,KIFC1,POU3F3 132 Cancer, Dermatological Diseases and Conditions, Organismal Injury and Abnormalities skin cancer Skin cancer 3.01E-08 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,C1QTNF3,REG1A,ITIH6,PDZD7,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,TTC24,L1CAM,TSPEAR,SCARF2,SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,PTGIR,PGBD4,DDO,CALML3,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,CLPB,TULP4,ANGPTL3,FCGBP,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,ANKRD50,NUBP1,DPY19L3,ZSWIM9,ABCA5,MFSD1,ZMYM1,CSMD3,TRIM2,PGK1,ITGB3,MEGF11,TRIM36,COLEC11,SUSD2,CACHD1,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,ACAA1,WRN,PIF1,FAT4,IFI44,THAP2,KIFC1,POU3F3 135 Neurological Disease, Organismal Injury and Abnormalities brain lesion Brain lesion 3.16E-08 CELSR1,KRT8,DGAT1,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,PNLIP,LRP6,SNX33,REG1A,ITIH6,PDZD7,PTK7,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,THSD4,TTC24,L1CAM,SCARF2,TSPEAR,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,SYT12,FIBCD1,NANOS1,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,POLI,TRIM56,PTPRK,SLC16A7,MMRN2,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,AIMP2,FLNC,SLC5A7,CYP39A1,HCRTR2,VWDE,RNF207,ANOS1,MKX,SVEP1,GSTM3,XPO7,TULP4,SOD3,CCDC13,ABCA3,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,DPY19L3,ZSWIM9,ABCA5,MFSD1,CSMD3,FUT6,TRIM2,PGK1,ITGB3,MEGF11,CASP2,COLEC11,SUSD2,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,ACAA1,KMT5A,WRN,PIF1,PRKCSH,FAT4,IFI44,TMEM161B,SLC16A4 117 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities hepatobiliary neoplasm Hepatobiliary neoplasm 3.31E-08 -1.982 -2.034 CELSR1,KRT8,LGMN,CHRNA10,SULT1A2,GLB1,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,CACFD1,NLGN2,AGA,PTPRG,TNXB,HSD3B2,THSD4,RASEF,CR1,TTC24,L1CAM,TSPEAR,SCARF2,SNAP25,GNAO1,FASN,HARBI1,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,CALCRL,DDX20,CSRNP3,LRP4,TENM3,ATL2,BCHE,PLIN2,POLI,MB21D2,MMRN2,MMRN1,BIRC2,HDHD5,LRP5,L3HYPDH,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,SYCE2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,DDO,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,TULP4,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,ANKRD50,HNRNPM,ZSWIM9,ABCA5,ZMYM1,CSMD3,FUT6,TRIM2,PGK1,MEGF11,CASP2,TRIM36,SUSD2,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,ACAA1,KMT5A,PRKCSH,FAT4,KIFC1,TMEM161B 106 Cancer, Dermatological Diseases and Conditions, Organismal Injury and Abnormalities cutaneous melanoma Cutaneous melanoma 3.45E-08 CELSR1,KRT8,SULT1A2,TRIM3,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,C1QTNF3,REG1A,ITIH6,PDZD7,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,THSD4,RASEF,CR1,TTC24,L1CAM,SCARF2,TSPEAR,SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,CALCRL,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,LRP4,MEGF6,TENM3,ATL2,BCHE,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,PGBD4,DDO,CALML3,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,CLPB,XPO7,TULP4,ANGPTL3,FCGBP,CCDC13,ABCA3,NCAN,RRP12,NUBP1,HNRNPM,DPY19L3,ZSWIM9,ABCA5,MFSD1,ZMYM1,CSMD3,TRIM2,PGK1,ITGB3,MEGF11,TRIM36,COLEC11,SUSD2,CACHD1,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,ACAA1,WRN,PIF1,FAT4,THAP2,KIFC1,POU3F3 128 Cancer, Organismal Injury and Abnormalities malignant solid tumor Malignant solid tumor 3.51E-08 -0.917 -0.919 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,AIMP2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,RABL2B,VPS25,PGBD4,DDO,ARL6IP4,RNF207,CALML3,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,H2BC21,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 174 Cancer, Neurological Disease, Organismal Injury and Abnormalities brain tumor Brain tumor 3.99E-08 CELSR1,KRT8,DGAT1,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,PNLIP,LRP6,SNX33,REG1A,ITIH6,PDZD7,PTK7,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,THSD4,TTC24,L1CAM,SCARF2,TSPEAR,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,SYT12,FIBCD1,NANOS1,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,PLIN2,FAM111A,POLI,TRIM56,PTPRK,SLC16A7,MMRN2,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,AIMP2,FLNC,SLC5A7,CYP39A1,HCRTR2,VWDE,RNF207,ANOS1,MKX,SVEP1,GSTM3,XPO7,TULP4,SOD3,CCDC13,ABCA3,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,DPY19L3,ZSWIM9,ABCA5,MFSD1,CSMD3,FUT6,TRIM2,PGK1,ITGB3,MEGF11,CASP2,COLEC11,SUSD2,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,ACAA1,KMT5A,WRN,PIF1,PRKCSH,FAT4,IFI44,TMEM161B,SLC16A4 116 Cancer, Neurological Disease, Organismal Injury and Abnormalities brain glioma formation Brain glioma 4.11E-08 CELSR1,KRT8,DGAT1,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,PNLIP,LRP6,SNX33,REG1A,ITIH6,PDZD7,PTK7,NLGN2,AGA,PTPRG,ADGRG6,SCARF1,HSD3B2,THSD4,TTC24,L1CAM,SCARF2,TSPEAR,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,SYT12,FIBCD1,NANOS1,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,PLIN2,FAM111A,POLI,TRIM56,PTPRK,SLC16A7,MMRN2,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,AIMP2,FLNC,SLC5A7,CYP39A1,HCRTR2,VWDE,RNF207,ANOS1,MKX,SVEP1,GSTM3,XPO7,TULP4,SOD3,CCDC13,ABCA3,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,DPY19L3,ZSWIM9,ABCA5,MFSD1,CSMD3,FUT6,TRIM2,PGK1,ITGB3,MEGF11,CASP2,COLEC11,SUSD2,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,ACAA1,KMT5A,WRN,PIF1,PRKCSH,FAT4,IFI44,TMEM161B,SLC16A4 115 Cancer, Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities cancer Liver cancer 4.91E-08 -1.982 -2.048 BIRC2,KRT8,CELSR1,LRP5,LGMN,CHRNA10,SULT1A2,TMPRSS6,GLB1,PLG,SLC16A14,AOC1,AKNA,TNR,RRM2,TRPM2,TKFC,PNLIP,FGL1,FLNC,SLC5A7,CYP39A1,LRP6,ADRM1,HCRTR2,VWDE,SNX33,C1QTNF3,DDO,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,CACFD1,TULP4,NLGN2,SOD3,CCDC13,PTPRG,ABCA3,TNXB,NCAN,ANKRD50,HNRNPM,HSD3B2,THSD4,RASEF,CR1,TTC24,L1CAM,SCARF2,TSPEAR,ZSWIM9,GNAO1,ABCA5,ZMYM1,FASN,HARBI1,CSMD3,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,FUT6,TRIM2,PGK1,DDX20,CASP2,TRIM36,CSRNP3,SUSD2,LRP4,ANGPT2,TENM3,TSNARE1,CUBN,ANK1,BCHE,ACAA1,KMT5A,PLIN2,POLI,MB21D2,PRKCSH,FAT4,MMRN2,KIFC1,MMRN1 92 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities digestive system cancer Digestive system cancer 4.95E-08 -1.982 -2.030 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,VPS25,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,CLPB,TULP4,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,ABCA5,MFSD1,ZMYM1,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,ANGPT2,CEBPD,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PRKCSH,FAT4,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 159 Cancer, Organismal Injury and Abnormalities carcinoma Carcinoma 6.50E-08 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,BBLN,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,RABL2B,VPS25,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,RAB11A,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 170 Cancer, Organismal Injury and Abnormalities extrapancreatic malignant tumor Extrapancreatic malignant tumor 7.61E-08 -1.026 -1.053 KRT8,CELSR1,LGMN,CHRNA10,SULT1A2,DGAT1,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ITIH6,PDZD7,CACFD1,TPPP3,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,ASPG,TTC24,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,NANOS1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,BIRC2,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,AIMP2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,RABL2B,VPS25,PGBD4,DDO,ARL6IP4,RNF207,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,CLPB,TULP4,ANGPTL3,FCGBP,SOD3,H2BC21,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ZSWIM9,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,TRIM2,PGK1,ITGB3,RRP36,MEGF11,CASP2,TRIM36,COLEC11,SUSD2,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,PRKCSH,FAT4,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 170 Cancer, Organismal Injury and Abnormalities grade 3-4 tumor Grade 3-4 tumor 1.03E-07 CELSR1,KRT8,DGAT1,BIRC3,SLC16A14,AOC1,TRPM2,PNLIP,LRP6,SNX33,REG1A,ITIH6,PDZD7,PTK7,AGA,PTPRG,ADGRG6,SCARF1,HSD3B2,THSD4,TTC24,L1CAM,SCARF2,TSPEAR,GNAO1,EMX2,FASN,FAM234B,TMEM187,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,SYT12,FIBCD1,NANOS1,MEGF10,TSG101,LRP4,MEGF6,TENM3,PLIN2,POLI,TRIM56,PTPRK,SLC16A7,MMRN2,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,CYP39A1,HCRTR2,VWDE,ANOS1,MKX,SVEP1,GSTM3,XPO7,SOD3,CCDC13,ABCA3,C1QTNF4,ANKRD50,NUBP1,HNRNPM,DPY19L3,ZSWIM9,ABCA5,MFSD1,CSMD3,FUT6,PGK1,ITGB3,MEGF11,CASP2,COLEC11,SUSD2,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,ACAA1,KMT5A,WRN,PIF1,PRKCSH,FAT4,DUT,IFI44,TMEM161B 102 Cancer, Neurological Disease, Organismal Injury and Abnormalities glioma cancer Glioma cancer 1.19E-07 CELSR1,KRT8,DGAT1,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,PNLIP,LRP6,SNX33,REG1A,ITIH6,PDZD7,PTK7,NLGN2,AGA,PTPRG,ADGRG6,SCARF1,HSD3B2,THSD4,TTC24,L1CAM,SCARF2,TSPEAR,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,SYT12,FIBCD1,NANOS1,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,PLIN2,FAM111A,POLI,TRIM56,PTPRK,SLC16A7,MMRN2,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,AIMP2,FLNC,SLC5A7,CYP39A1,HCRTR2,VWDE,RNF207,ANOS1,MKX,SVEP1,GSTM3,XPO7,TULP4,SOD3,CCDC13,ABCA3,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,DPY19L3,ZSWIM9,ABCA5,MFSD1,CSMD3,FUT6,TRIM2,PGK1,ITGB3,MEGF11,CASP2,COLEC11,SUSD2,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,ACAA1,KMT5A,WRN,PIF1,PRKCSH,FAT4,IFI44,TMEM161B,SLC16A4 115 Cancer, Organismal Injury and Abnormalities melanoma Melanoma 1.29E-07 KRT8,CELSR1,SULT1A2,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,C1QTNF3,REG1A,ITIH6,PDZD7,PTK7,CHAC1,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,RASEF,CR1,THSD4,TTC24,L1CAM,TSPEAR,SCARF2,SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,SYT12,DDX20,FIBCD1,EMILIN2,MEGF10,CSRNP3,FRRS1,LRP4,MEGF6,TENM3,ATL2,BCHE,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,MMRN1,HDHD5,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,PTGIR,PGBD4,DDO,CALML3,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,CLPB,TULP4,ANGPTL3,FCGBP,CCDC13,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,NUBP1,DPY19L3,ZSWIM9,ABCA5,MFSD1,ZMYM1,CSMD3,TRIM2,PGK1,ITGB3,MEGF11,TRIM36,COLEC11,SUSD2,CACHD1,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,FAT4,THAP2,KIFC1,SLC16A4,POU3F3 135 Cancer, Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities liver tumor Liver tumor 1.50E-07 -1.982 -2.037 CELSR1,KRT8,LGMN,CHRNA10,SULT1A2,GLB1,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,C1QTNF3,CACFD1,NLGN2,PTPRG,TNXB,HSD3B2,THSD4,RASEF,CR1,TTC24,L1CAM,SCARF2,TSPEAR,GNAO1,FASN,HARBI1,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,CALCRL,DDX20,CSRNP3,LRP4,TENM3,ATL2,BCHE,PLIN2,POLI,MB21D2,MMRN2,MMRN1,BIRC2,HDHD5,LRP5,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,SYCE2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,DDO,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,TULP4,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,ANKRD50,HNRNPM,ZSWIM9,ABCA5,ZMYM1,CSMD3,FUT6,TRIM2,PGK1,MEGF11,CASP2,TRIM36,SUSD2,ANGPT2,TSNARE1,CUBN,ANK1,ACAA1,KMT5A,PRKCSH,FAT4,KIFC1 100 Cancer, Neurological Disease, Organismal Injury and Abnormalities glioma cancer Grade 3-4 glioma cancer 1.54E-07 CELSR1,KRT8,DGAT1,BIRC3,SLC16A14,AOC1,TRPM2,PNLIP,LRP6,SNX33,REG1A,ITIH6,PDZD7,PTK7,AGA,PTPRG,ADGRG6,SCARF1,HSD3B2,THSD4,TTC24,L1CAM,SCARF2,TSPEAR,GNAO1,EMX2,FASN,FAM234B,TMEM187,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,SYT12,FIBCD1,NANOS1,MEGF10,TSG101,LRP4,MEGF6,TENM3,PLIN2,POLI,TRIM56,PTPRK,SLC16A7,MMRN2,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,CYP39A1,HCRTR2,VWDE,ANOS1,MKX,SVEP1,GSTM3,XPO7,SOD3,CCDC13,ABCA3,C1QTNF4,ANKRD50,NUBP1,HNRNPM,DPY19L3,ZSWIM9,ABCA5,MFSD1,CSMD3,FUT6,PGK1,ITGB3,MEGF11,CASP2,COLEC11,SUSD2,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,ACAA1,KMT5A,WRN,PIF1,PRKCSH,FAT4,IFI44,TMEM161B 101 Cancer, Neurological Disease, Organismal Injury and Abnormalities central nervous system cancer Central nervous system cancer 1.71E-07 CELSR1,KRT8,DGAT1,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,PNLIP,LRP6,SNX33,REG1A,ITIH6,PDZD7,PTK7,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,THSD4,TTC24,L1CAM,SCARF2,TSPEAR,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,SYT12,FIBCD1,NANOS1,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,PLIN2,FAM111A,POLI,TRIM56,PTPRK,SLC16A7,MMRN2,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,CYP39A1,AIMP2,FLNC,SLC5A7,HCRTR2,VWDE,RNF207,ANOS1,MKX,SVEP1,GSTM3,XPO7,TULP4,SOD3,CCDC13,ABCA3,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,DPY19L3,ZSWIM9,ABCA5,MFSD1,CSMD3,FUT6,TRIM2,PGK1,ITGB3,MEGF11,CASP2,COLEC11,SUSD2,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,ACAA1,KMT5A,WRN,PIF1,PRKCSH,FAT4,IFI44,TMEM161B,SLC16A4 116 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities development Development of digestive organ tumor 1.83E-07 CELSR1,KRT8,LGMN,CHRNA10,TRIM3,GLB1,BIRC3,AOC1,TRPM2,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,PDZD7,CACFD1,CHAC1,NLGN2,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,THSD4,ASPG,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),GNAO1,EMX2,FASN,TMEM187,PKD1L2,SERINC2,MAPK4,CD209,SYT12,DDX20,MEGF10,CSRNP3,MEGF6,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,MB21D2,PTPRK,MMRN2,MMRN1,BIRC2,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,CHRNB3,FLNC,HCRTR2,VWDE,PTGIR,DDO,ARL6IP4,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,CLPB,XPO7,TULP4,FCGBP,SOD3,CCDC13,ABCA3,NCAN,RRP12,C1QTNF4,HNRNPM,DPY19L3,ZSWIM9,ABCA5,ZMYM1,CSMD3,C1QL1,FUT6,PGK1,RRP36,MEGF11,CASP2,SUSD2,CACHD1,ANGPT2,CUBN,ANK1,TNFSF14,ACAA1,KMT5A,WRN,FAT4,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 113 Cancer, Neurological Disease, Organismal Injury and Abnormalities high grade astrocytoma High grade astrocytoma 1.94E-07 CELSR1,KRT8,LRP5,L3HYPDH,ADAMTS16,DGAT1,TMPRSS6,GLB1,PLG,BIRC3,SLC16A14,BBX,AKNA,TNR,RRM2,TRPM2,CHRNB3,PNLIP,FLNC,SLC5A7,CYP39A1,LRP6,HCRTR2,VWDE,SNX33,REG1A,ANOS1,MKX,SVEP1,ITIH6,GSTM3,XPO7,PDZD7,PTK7,NLGN2,SOD3,AGA,PTPRG,ABCA3,ADGRG6,SCARF1,C1QTNF4,ANKRD50,HNRNPM,HSD3B2,DPY19L3,THSD4,TTC24,L1CAM,SCARF2,TSPEAR,ZSWIM9,GNAO1,EMX2,ABCA5,FASN,FAM234B,TMEM187,CSMD3,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,SYT12,FUT6,PGK1,FIBCD1,ITGB3,NANOS1,MEGF11,CASP2,COLEC11,FRRS1,SUSD2,TSG101,LRP4,CACHD1,ANGPT2,MEGF6,TENM3,TSNARE1,CUBN,ACAA1,KMT5A,PLIN2,FAM111A,POLI,PIF1,PRKCSH,PTPRK,FAT4,MMRN2,IFI44,TMEM161B 95 Cancer, Organismal Injury and Abnormalities development Development of adenocarcinoma 2.16E-07 CELSR1,KRT8,LGMN,CHRNA10,TRIM3,GLB1,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,SNX33,HSPA12B,REG1A,ITIH6,PTK7,NLGN2,PTPRG,TNXB,ADGRG6,HSD3B2,RASEF,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,HARBI1,FAM234B,CGAS,PKD1L2,SERINC2,MAPK4,CD209,CALCRL,DDX20,FIBCD1,MEGF10,FRRS1,LRP4,MEGF6,TENM3,BCHE,PLIN2,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN1,BIRC2,LRP5,ADAMTS16,TMPRSS6,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,HCRTR2,VWDE,RABL2B,PGBD4,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,GSTM3,CLPB,XPO7,TULP4,ANGPTL3,FCGBP,ABCA3,NCAN,RRP12,C1QTNF4,ANKRD50,NUBP1,HNRNPM,DPY19L3,ABCA5,ZMYM1,CSMD3,TRIM2,PGK1,ITGB3,CASP2,TRIM36,COLEC11,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,WRN,FAT4,IFI44,THAP2,TMEM161B,SLC16A4,POU3F3 109 Cancer, Neurological Disease, Organismal Injury and Abnormalities astrocytoma Grade 4 astrocytoma 4.11E-07 CELSR1,KRT8,LRP5,L3HYPDH,ADAMTS16,DGAT1,TMPRSS6,PLG,BIRC3,SLC16A14,BBX,AKNA,TNR,RRM2,TRPM2,CHRNB3,PNLIP,FLNC,SLC5A7,CYP39A1,LRP6,HCRTR2,VWDE,SNX33,REG1A,ANOS1,MKX,SVEP1,ITIH6,GSTM3,XPO7,PDZD7,PTK7,SOD3,AGA,PTPRG,ABCA3,ADGRG6,SCARF1,C1QTNF4,ANKRD50,HNRNPM,HSD3B2,DPY19L3,THSD4,TTC24,L1CAM,SCARF2,TSPEAR,ZSWIM9,GNAO1,EMX2,ABCA5,FASN,FAM234B,TMEM187,CSMD3,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,SYT12,FUT6,PGK1,FIBCD1,ITGB3,NANOS1,MEGF11,CASP2,COLEC11,SUSD2,TSG101,LRP4,CACHD1,ANGPT2,MEGF6,TENM3,TSNARE1,CUBN,ACAA1,KMT5A,PLIN2,POLI,PIF1,PRKCSH,PTPRK,FAT4,MMRN2,IFI44,TMEM161B 91 Cancer, Neurological Disease, Organismal Injury and Abnormalities high grade glioma Grade 4 high grade glioma 4.11E-07 CELSR1,KRT8,LRP5,L3HYPDH,ADAMTS16,DGAT1,TMPRSS6,PLG,BIRC3,SLC16A14,BBX,AKNA,TNR,RRM2,TRPM2,CHRNB3,PNLIP,FLNC,SLC5A7,CYP39A1,LRP6,HCRTR2,VWDE,SNX33,REG1A,ANOS1,MKX,SVEP1,ITIH6,GSTM3,XPO7,PDZD7,PTK7,SOD3,AGA,PTPRG,ABCA3,ADGRG6,SCARF1,C1QTNF4,ANKRD50,HNRNPM,HSD3B2,DPY19L3,THSD4,TTC24,L1CAM,SCARF2,TSPEAR,ZSWIM9,GNAO1,EMX2,ABCA5,FASN,FAM234B,TMEM187,CSMD3,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,SYT12,FUT6,PGK1,FIBCD1,ITGB3,NANOS1,MEGF11,CASP2,COLEC11,SUSD2,TSG101,LRP4,CACHD1,ANGPT2,MEGF6,TENM3,TSNARE1,CUBN,ACAA1,KMT5A,PLIN2,POLI,PIF1,PRKCSH,PTPRK,FAT4,MMRN2,IFI44,TMEM161B 91 Cancer, Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities liver carcinoma Liver carcinoma 4.45E-07 BIRC2,CELSR1,KRT8,LRP5,LGMN,CHRNA10,SULT1A2,TMPRSS6,GLB1,PLG,SLC16A14,AOC1,AKNA,TNR,RRM2,TRPM2,TKFC,PNLIP,FGL1,FLNC,SLC5A7,CYP39A1,LRP6,ADRM1,HCRTR2,VWDE,SNX33,C1QTNF3,DDO,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,CACFD1,TULP4,NLGN2,SOD3,CCDC13,PTPRG,ABCA3,TNXB,NCAN,ANKRD50,HNRNPM,HSD3B2,THSD4,RASEF,CR1,TTC24,SCARF2,TSPEAR,ZSWIM9,GNAO1,ABCA5,ZMYM1,FASN,HARBI1,CSMD3,PKD1L2,SERINC2,MAPK4,CALCRL,FUT6,TRIM2,PGK1,CASP2,TRIM36,CSRNP3,SUSD2,LRP4,TENM3,TSNARE1,CUBN,ANK1,BCHE,ACAA1,KMT5A,POLI,MB21D2,PRKCSH,FAT4,MMRN2,KIFC1,MMRN1 87 Cancer, Neurological Disease, Organismal Injury and Abnormalities brain astrocytoma Brain astrocytoma 4.66E-07 CELSR1,KRT8,LRP5,L3HYPDH,ADAMTS16,DGAT1,TMPRSS6,PLG,BIRC3,SLC16A14,BBX,AKNA,TNR,RRM2,TRPM2,CHRNB3,PNLIP,FLNC,SLC5A7,CYP39A1,LRP6,HCRTR2,VWDE,SNX33,REG1A,ANOS1,MKX,SVEP1,ITIH6,GSTM3,XPO7,PDZD7,PTK7,SOD3,AGA,PTPRG,ABCA3,ADGRG6,SCARF1,C1QTNF4,ANKRD50,HNRNPM,HSD3B2,DPY19L3,THSD4,TTC24,L1CAM,SCARF2,TSPEAR,ZSWIM9,GNAO1,EMX2,ABCA5,FASN,FAM234B,TMEM187,CSMD3,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,SYT12,FUT6,PGK1,FIBCD1,ITGB3,NANOS1,MEGF11,CASP2,COLEC11,SUSD2,TSG101,LRP4,CACHD1,ANGPT2,MEGF6,TENM3,TSNARE1,CUBN,ACAA1,KMT5A,PLIN2,POLI,PIF1,PRKCSH,PTPRK,FAT4,MMRN2,IFI44,TMEM161B 91 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities upper gastrointestinal carcinoma Upper gastrointestinal carcinoma 8.04E-07 HDHD5,CELSR1,LRP5,L3HYPDH,LGMN,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,BIRC3,AOC1,AKNA,TNR,RRM2,TRPM2,CHRNB3,FLNC,LRP6,HCRTR2,VWDE,PTGIR,MATR3,PGBD4,DDO,ANOS1,TRAF3IP2,SVEP1,MGAT4C,CLPB,XPO7,PDZD7,CACFD1,TULP4,FCGBP,NLGN2,SOD3,CCDC13,PTPRG,TNXB,NCAN,SCARF1,C1QTNF4,ANKRD50,HNRNPM,DPY19L3,THSD4,CR1,SCARF2,TSPEAR,ZSWIM9,CALM1 (includes others),SNAP25,ABCA5,FASN,HARBI1,CSMD3,PKD1L2,SERINC2,C1QL1,CD209,PGK1,RRP36,EMILIN2,CASP2,MEGF10,COLEC11,FRRS1,LRP4,CACHD1,ANGPT2,MEGF6,TENM3,CUBN,ANK1,PPP1CA,BCHE,ACAA1,KMT5A,PLIN2,FAM111A,WRN,POLI,PRKCSH,PTPRK,FAT4,MMRN1,TMEM161B,SLC16A4,POU3F3 89 Cancer, Neurological Disease, Organismal Injury and Abnormalities nervous system neoplasm Nervous system neoplasm 9.16E-07 CELSR1,KRT8,DGAT1,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,PNLIP,LRP6,SNX33,REG1A,ITIH6,PDZD7,PTK7,NLGN2,AGA,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,THSD4,TTC24,L1CAM,SCARF2,TSPEAR,GNAO1,EMX2,FASN,HARBI1,FAM234B,TMEM187,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,SYT12,FIBCD1,NANOS1,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,PLIN2,FAM111A,POLI,TRIM56,PTPRK,SLC16A7,MMRN2,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,AIMP2,FLNC,SLC5A7,CYP39A1,HCRTR2,VWDE,RNF207,ANOS1,MKX,SVEP1,GSTM3,XPO7,TULP4,SOD3,CCDC13,ABCA3,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,DPY19L3,ZSWIM9,ABCA5,MFSD1,CSMD3,FUT6,TRIM2,PGK1,ITGB3,MEGF11,CASP2,COLEC11,SUSD2,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,TNFSF14,ACAA1,KMT5A,WRN,PIF1,PRKCSH,FAT4,DUT,IFI44,TMEM161B,SLC16A4 117 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease breast or gynecological cancer Breast or gynecological cancer 9.66E-07 CELSR1,KRT8,LGMN,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,LRP6,SNX33,HSPA12B,ITIH6,PTK7,NLGN2,PTPRG,TNXB,ADGRG6,HSD3B2,THSD4,RASEF,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,FASN,HARBI1,FAM234B,CGAS,PKD1L2,SERINC2,MAPK4,CD209,CALCRL,DDX20,EMILIN2,MEGF10,FRRS1,TSG101,LRP4,MEGF6,TENM3,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN1,BIRC2,CLEC10A,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,ADRM1,HCRTR2,VWDE,RABL2B,PGBD4,RNF207,ANOS1,TRAF3IP2,SVEP1,ALDH7A1,GSTM3,XPO7,TULP4,ANGPTL3,FCGBP,H2BC21,ABCA3,NCAN,RRP12,C1QTNF4,ANKRD50,NUBP1,HNRNPM,ABCA5,MFSD1,ZMYM1,CSMD3,PGK1,ITGB3,CASP2,TRIM36,COLEC11,CACHD1,ANGPT2,CEBPD,TSNARE1,CUBN,ANK1,ETNK1,ACAA1,KMT5A,WRN,PIF1,FAT4,IFI44,KIFC1,SLC16A4,POU3F3 116 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease female genital tract cancer Female genital tract cancer 1.05E-06 CELSR1,KRT8,LGMN,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,SNX33,HSPA12B,ITIH6,PTK7,NLGN2,PTPRG,TNXB,HSD3B2,THSD4,RASEF,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,HARBI1,FAM234B,CGAS,PKD1L2,SERINC2,MAPK4,CD209,CALCRL,DDX20,MEGF10,FRRS1,TSG101,LRP4,MEGF6,TENM3,BCHE,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN1,BIRC2,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,HCRTR2,VWDE,RABL2B,PGBD4,RNF207,ANOS1,TRAF3IP2,SVEP1,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,ABCA3,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,ABCA5,MFSD1,ZMYM1,CSMD3,PGK1,ITGB3,CASP2,TRIM36,COLEC11,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,PIF1,FAT4,IFI44,KIFC1,SLC16A4,POU3F3 100 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities upper gastrointestinal tract cancer Upper gastrointestinal tract cancer 1.58E-06 HDHD5,CELSR1,LRP5,L3HYPDH,LGMN,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,BIRC3,AOC1,AKNA,TNR,RRM2,TRPM2,CHRNB3,FLNC,LRP6,HCRTR2,VWDE,PTGIR,MATR3,PGBD4,DDO,ANOS1,TRAF3IP2,SVEP1,MGAT4C,CLPB,XPO7,PDZD7,CACFD1,TULP4,FCGBP,NLGN2,SOD3,CCDC13,PTPRG,TNXB,NCAN,SCARF1,C1QTNF4,ANKRD50,HNRNPM,DPY19L3,THSD4,CR1,SCARF2,TSPEAR,ZSWIM9,CALM1 (includes others),SNAP25,ABCA5,FASN,HARBI1,CSMD3,PKD1L2,SERINC2,C1QL1,CD209,PGK1,RRP36,EMILIN2,CASP2,MEGF10,COLEC11,FRRS1,LRP4,CACHD1,ANGPT2,MEGF6,TENM3,CUBN,ANK1,PPP1CA,BCHE,ACAA1,KMT5A,PLIN2,FAM111A,WRN,POLI,PRKCSH,PTPRK,FAT4,MMRN1,TMEM161B,SLC16A4,POU3F3 90 Cancer, Organismal Injury and Abnormalities pelvic cancer Pelvic cancer 1.62E-06 KRT8,CELSR1,LGMN,CHRNA10,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,ITIH6,PDZD7,PTK7,CHAC1,NLGN2,PTPRG,TNXB,ADGRG6,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,DDX20,EMILIN2,MEGF10,FRRS1,TSG101,LRP4,MEGF6,TENM3,BCHE,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN1,BIRC2,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,RABL2B,PGBD4,DDO,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,PGK1,ITGB3,MEGF11,CASP2,TRIM36,COLEC11,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,PPP1CA,KMT5A,WRN,PIF1,FAT4,IFI44,KIFC1,SLC16A4,POU3F3 124 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease tumorigenesis Tumorigenesis of reproductive tract 1.68E-06 CELSR1,KRT8,LGMN,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,SNX33,HSPA12B,ITIH6,PTK7,NLGN2,PTPRG,TNXB,HSD3B2,THSD4,RASEF,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,HARBI1,FAM234B,CGAS,PKD1L2,SERINC2,MAPK4,CD209,CALCRL,DDX20,MEGF10,FRRS1,TSG101,LRP4,MEGF6,TENM3,BCHE,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN1,BIRC2,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,HCRTR2,VWDE,RABL2B,PGBD4,RNF207,ANOS1,TRAF3IP2,SVEP1,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,ABCA3,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,ABCA5,MFSD1,ZMYM1,CSMD3,PGK1,ITGB3,CASP2,TRIM36,COLEC11,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,PIF1,FAT4,DUT,IFI44,KIFC1,SLC16A4,POU3F3 101 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities pancreaticobiliary cancer Pancreaticobiliary cancer 1.69E-06 BIRC2,HDHD5,KRT8,CELSR1,L3HYPDH,TMPRSS6,TRIM3,PLG,AKNA,TNR,RRM2,TRPM2,TKFC,FGL1,FLNC,SLC5A7,LRP6,HCRTR2,VWDE,HSPA12B,DDO,RNF207,SVEP1,ALDH7A1,PDZD7,TULP4,TPPP3,PTK7,NLGN2,AGA,PTPRG,ABCA3,TNXB,NCAN,RRP12,L1CAM,SCARF2,TSPEAR,SNAP25,EMX2,FASN,CSMD3,DDX20,PGK1,ITGB3,TRIM36,COLEC11,FRRS1,SUSD2,LRP4,CACHD1,ANGPT2,TENM3,TSNARE1,CUBN,ANK1,PPP1CA,BCHE,WRN,POLI,TRIM56,PRKCSH,FAT4,TMEM161B,SLC16A4 65 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease female genital neoplasm Female genital neoplasm 1.81E-06 CELSR1,KRT8,LGMN,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,SNX33,HSPA12B,ITIH6,PTK7,NLGN2,PTPRG,TNXB,HSD3B2,THSD4,RASEF,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,HARBI1,FAM234B,CGAS,PKD1L2,SERINC2,MAPK4,CD209,CALCRL,DDX20,MEGF10,FRRS1,TSG101,LRP4,MEGF6,TENM3,BCHE,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN1,BIRC2,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,HCRTR2,VWDE,RABL2B,PGBD4,RNF207,ANOS1,TRAF3IP2,SVEP1,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,ABCA3,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,ABCA5,MFSD1,ZMYM1,CSMD3,PGK1,ITGB3,CASP2,TRIM36,COLEC11,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,PIF1,FAT4,DUT,IFI44,KIFC1,SLC16A4,POU3F3 101 Cancer, Organismal Injury and Abnormalities pelvic tumor Pelvic tumor 1.94E-06 KRT8,CELSR1,LGMN,CHRNA10,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,ITIH6,PDZD7,PTK7,CHAC1,NLGN2,PTPRG,TNXB,ADGRG6,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,DDX20,EMILIN2,MEGF10,FRRS1,TSG101,LRP4,MEGF6,TENM3,BCHE,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN1,BIRC2,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,RABL2B,PGBD4,DDO,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,PGK1,ITGB3,MEGF11,CASP2,TRIM36,COLEC11,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,PPP1CA,KMT5A,WRN,PIF1,FAT4,DUT,IFI44,KIFC1,SLC16A4,POU3F3 125 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities pancreaticobiliary carcinoma Pancreaticobiliary carcinoma 2.04E-06 BIRC2,HDHD5,KRT8,CELSR1,L3HYPDH,TMPRSS6,TRIM3,AKNA,TNR,RRM2,TRPM2,TKFC,FGL1,FLNC,SLC5A7,LRP6,HCRTR2,VWDE,HSPA12B,DDO,RNF207,SVEP1,ALDH7A1,PDZD7,TULP4,TPPP3,PTK7,NLGN2,AGA,PTPRG,ABCA3,TNXB,NCAN,RRP12,L1CAM,SCARF2,TSPEAR,SNAP25,EMX2,FASN,CSMD3,DDX20,PGK1,ITGB3,TRIM36,COLEC11,FRRS1,SUSD2,LRP4,CACHD1,ANGPT2,TENM3,TSNARE1,CUBN,ANK1,BCHE,WRN,POLI,TRIM56,PRKCSH,FAT4,TMEM161B,SLC16A4 63 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities non-colon gastrointestinal cancer Non-colon gastrointestinal cancer 2.61E-06 HDHD5,CELSR1,KRT8,LRP5,L3HYPDH,LGMN,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,BIRC3,AOC1,AKNA,TNR,RRM2,TRPM2,CHRNB3,FLNC,LRP6,HCRTR2,VWDE,PTGIR,MATR3,PGBD4,DDO,ANOS1,TRAF3IP2,SVEP1,MGAT4C,CLPB,XPO7,PDZD7,CACFD1,TULP4,FCGBP,NLGN2,SOD3,CCDC13,PTPRG,TNXB,NCAN,RRP12,SCARF1,C1QTNF4,ANKRD50,HNRNPM,DPY19L3,THSD4,CR1,SCARF2,TSPEAR,ZSWIM9,CALM1 (includes others),SNAP25,ABCA5,FASN,HARBI1,CSMD3,PKD1L2,SERINC2,C1QL1,CD209,PGK1,DDX20,RRP36,EMILIN2,CASP2,MEGF10,COLEC11,FRRS1,LRP4,CACHD1,ANGPT2,MEGF6,TENM3,CUBN,ANK1,PPP1CA,BCHE,ACAA1,KMT5A,PLIN2,FAM111A,WRN,POLI,PRKCSH,PTPRK,FAT4,MMRN1,TMEM161B,SLC16A4,POU3F3 93 Cancer, Organismal Injury and Abnormalities, Respiratory Disease lung adenocarcinoma Lung adenocarcinoma 2.75E-06 KRT8,LRP5,GNAO1,ABCA5,CGAS,CSMD3,AOC1,SERINC2,TNR,RRM2,TRPM2,CHRNB3,PNLIP,TRIM2,FIBCD1,FGL1,FLNC,SLC5A7,VWDE,REG1A,TENM3,TSNARE1,CUBN,SVEP1,MGAT4C,CLPB,BCHE,TULP4,PLIN2,ANGPTL3,LRRC74A,WRN,PTK7,NLGN2,MB21D2,FAT4,TNXB,NCAN,ADGRG6,RRP12,MMRN1,TMEM161B,DPY19L3,CR1,L1CAM,TSPEAR 46 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities colon adenocarcinoma Colon adenocarcinoma 3.04E-06 CELSR1,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,TRIM3,GLB1,PLG,AOC1,TNR,TRPM2,CHRNB3,FGL1,LRP6,HCRTR2,VWDE,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ARL6IP4,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,CLPB,XPO7,TULP4,FCGBP,CHAC1,NLGN2,SOD3,ABCA3,TNXB,NCAN,ADGRG6,RRP12,SCARF1,HNRNPM,HSD3B2,DPY19L3,THSD4,ASPG,L1CAM,TSPEAR,GNAO1,EMX2,ABCA5,ZMYM1,FASN,TMEM187,CSMD3,PKD1L2,MAPK4,C1QL1,CD209,SYT12,FUT6,PGK1,DDX20,RRP36,MEGF11,MEGF10,CSRNP3,SUSD2,CACHD1,ANGPT2,TENM3,CUBN,ATL2,ANK1,TNFSF14,BCHE,LRRC74A,WRN,MB21D2,PTPRK,FAT4,MMRN2,THAP2,KIFC1,MMRN1,SLC16A4,POU3F3 86 Cancer, Organismal Injury and Abnormalities endometrioid carcinoma Endometrioid carcinoma 3.06E-06 BIRC2,CELSR1,KRT8,LRP5,LGMN,ADAMTS16,TMPRSS6,TRIM3,GLB1,SLC16A14,AKNA,TNR,RRM2,TRPM2,CHRNB3,TKFC,PNLIP,FLNC,HCRTR2,VWDE,SNX33,RABL2B,HSPA12B,PGBD4,RNF207,ANOS1,TRAF3IP2,SVEP1,ITIH6,XPO7,TULP4,ANGPTL3,FCGBP,NLGN2,PTPRG,ABCA3,TNXB,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,HSD3B2,RASEF,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,ABCA5,ZMYM1,HARBI1,CGAS,CSMD3,MAPK4,CD209,CALCRL,PGK1,DDX20,ITGB3,CASP2,MEGF10,TRIM36,COLEC11,FRRS1,LRP4,CACHD1,ANGPT2,MEGF6,TENM3,TSNARE1,CUBN,LRRC74A,POLI,TRIM56,PTPRK,SLC16A7,FAT4,IFI44,MMRN1,SLC16A4,POU3F3 84 Cancer, Organismal Injury and Abnormalities hematological or lymphatic system tumor Hematological or lymphatic system tumor 3.79E-06 0.152 0.128 CELSR1,KRT8,LGMN,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,BIRC3,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,FGL1,FLNC,SLC5A7,LRP6,VWDE,RABL2B,ANOS1,SVEP1,ALDH7A1,XPO7,TULP4,FCGBP,PTK7,AGA,PTPRG,TNXB,NCAN,ADGRG6,RRP12,ANKRD50,NUBP1,HNRNPM,RASEF,CR1,L1CAM,TSPEAR,ABCA5,ZMYM1,FASN,CGAS,CSMD3,PKD1L2,SERINC2,MAPK4,CALCRL,PGK1,ITGB3,EMILIN2,CASP2,MEGF10,FRRS1,SUSD2,LRP4,CACHD1,ANGPT2,CEBPD,MEGF6,TENM3,TSNARE1,CUBN,ATL2,ANK1,PPP1CA,ETNK1,BCHE,KMT5A,POLI,PTPRK,SLC16A7,FAT4,MMRN2,IFI44 77 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease development Development of genital tumor 3.97E-06 CELSR1,KRT8,LGMN,TRIM3,GLB1,BIRC3,SLC16A14,TRPM2,TKFC,PNLIP,SNX33,HSPA12B,ITIH6,PTK7,NLGN2,PTPRG,TNXB,HSD3B2,THSD4,RASEF,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,HARBI1,FAM234B,CGAS,SERINC2,MAPK4,CD209,CALCRL,DDX20,MEGF10,FRRS1,LRP4,MEGF6,TENM3,BCHE,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN1,BIRC2,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,HCRTR2,VWDE,RABL2B,PGBD4,RNF207,ANOS1,TRAF3IP2,SVEP1,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,ABCA3,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,ABCA5,MFSD1,ZMYM1,CSMD3,PGK1,ITGB3,CASP2,TRIM36,COLEC11,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,PIF1,FAT4,DUT,IFI44,KIFC1,SLC16A4,POU3F3 98 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities colon cancer Colon cancer 4.62E-06 CELSR1,LRP5,L3HYPDH,SULT1A2,ADAMTS16,TMPRSS6,TRIM3,GLB1,PLG,AOC1,TNR,RRM2,TRPM2,CHRNB3,FGL1,LRP6,HCRTR2,VWDE,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ARL6IP4,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,CLPB,XPO7,TULP4,FCGBP,CHAC1,NLGN2,SOD3,ABCA3,TNXB,NCAN,ADGRG6,RRP12,SCARF1,HNRNPM,HSD3B2,DPY19L3,THSD4,ASPG,L1CAM,TSPEAR,GNAO1,EMX2,ABCA5,ZMYM1,FASN,TMEM187,CSMD3,B4GALT1,PKD1L2,MAPK4,C1QL1,CD209,SYT12,FUT6,PGK1,DDX20,RRP36,MEGF11,MEGF10,CSRNP3,SUSD2,CACHD1,ANGPT2,TENM3,CUBN,ATL2,ANK1,TNFSF14,BCHE,LRRC74A,WRN,MB21D2,PTPRK,FAT4,MMRN2,THAP2,KIFC1,MMRN1,SLC16A4,POU3F3 89 Cancer, Organismal Injury and Abnormalities breast or colorectal cancer Breast or colorectal cancer 4.77E-06 CELSR1,KRT8,SULT1A2,TRIM3,GLB1,AOC1,TRPM2,FGL1,LRP6,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,PDZD7,PTK7,CHAC1,NLGN2,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,THSD4,RASEF,ASPG,L1CAM,TSPEAR,CALM1 (includes others),GNAO1,EMX2,FASN,TMEM187,B4GALT1,PKD1L2,MAPK4,CD209,SYT12,DDX20,EMILIN2,MEGF10,CSRNP3,TSG101,LRP4,TENM3,ATL2,BCHE,PLIN2,FAM111A,LRRC74A,POLI,MB21D2,PTPRK,MMRN2,MMRN1,BIRC2,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,TNR,RRM2,CHRNB3,FLNC,ADRM1,HCRTR2,VWDE,ARL6IP4,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,GSTM3,CLPB,XPO7,TULP4,FCGBP,SOD3,H2BC21,ABCA3,NCAN,RRP12,NUBP1,HNRNPM,DPY19L3,ABCA5,ZMYM1,CSMD3,C1QL1,FUT6,PGK1,ITGB3,RRP36,MEGF11,CASP2,SUSD2,CACHD1,ANGPT2,CEBPD,CUBN,ANK1,TNFSF14,ETNK1,ACAA1,KMT5A,WRN,FAT4,THAP2,KIFC1,SLC16A4,POU3F3 114 Cancer, Organismal Injury and Abnormalities breast or gastric cancer Breast or gastric cancer 5.23E-06 CELSR1,KRT8,LGMN,CHRNA10,TRIM3,GLB1,BIRC3,AOC1,LRP6,HSPA12B,PDZD7,CACFD1,PTK7,NLGN2,PTPRG,TNXB,ADGRG6,SCARF1,HSD3B2,THSD4,RASEF,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),FASN,FAM234B,PKD1L2,SERINC2,MAPK4,CD209,DDX20,EMILIN2,MEGF10,TSG101,LRP4,MEGF6,TENM3,BCHE,PLIN2,FAM111A,POLI,MB21D2,PTPRK,MMRN1,BIRC2,CLEC10A,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,ADRM1,HCRTR2,VWDE,PTGIR,DDO,ANOS1,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,GSTM3,XPO7,TULP4,FCGBP,H2BC21,CCDC13,ABCA3,NCAN,RRP12,C1QTNF4,ANKRD50,NUBP1,HNRNPM,DPY19L3,ZSWIM9,ABCA5,ZMYM1,CSMD3,C1QL1,PGK1,ITGB3,RRP36,CASP2,TRIM36,CACHD1,ANGPT2,CEBPD,CUBN,ANK1,ETNK1,ACAA1,KMT5A,WRN,FAT4,KIFC1,TMEM161B,SLC16A4,POU3F3 106 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease genital tract cancer Genital tract cancer 5.69E-06 CELSR1,KRT8,LGMN,CHRNA10,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,LRP6,SNX33,HSPA12B,ITIH6,PTK7,CHAC1,NLGN2,PTPRG,TNXB,ADGRG6,HSD3B2,THSD4,RASEF,ASPG,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CD209,CALCRL,DDX20,MEGF10,FRRS1,TSG101,LRP4,MEGF6,TENM3,BCHE,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN1,BIRC2,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,RABL2B,PGBD4,DDO,RNF207,ANOS1,TRAF3IP2,SVEP1,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,ABCA3,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,DPY19L3,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,FUT6,PGK1,ITGB3,MEGF11,CASP2,TRIM36,COLEC11,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,KMT5A,WRN,PIF1,FAT4,IFI44,KIFC1,SLC16A4,POU3F3 116 Cancer, Organismal Injury and Abnormalities malignant genitourinary solid tumor Malignant genitourinary solid tumor 6.07E-06 KRT8,CELSR1,LGMN,CHRNA10,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,ITIH6,PTK7,CHAC1,NLGN2,PTPRG,TNXB,ADGRG6,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,DDX20,NANOS1,EMILIN2,MEGF10,FRRS1,TSG101,LRP4,MEGF6,TENM3,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN1,BIRC2,CLEC10A,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,RABL2B,PGBD4,DDO,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,TULP4,ANGPTL3,FCGBP,H2BC21,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,PGK1,ITGB3,MEGF11,CASP2,TRIM36,COLEC11,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,FAT4,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 133 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities colorectal adenocarcinoma Colorectal adenocarcinoma 6.85E-06 CELSR1,KRT8,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,TRIM3,GLB1,PLG,AOC1,TNR,TRPM2,CHRNB3,FGL1,LRP6,HCRTR2,VWDE,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ARL6IP4,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,CLPB,XPO7,PDZD7,TULP4,FCGBP,CHAC1,NLGN2,SOD3,ABCA3,TNXB,NCAN,ADGRG6,RRP12,SCARF1,HNRNPM,HSD3B2,DPY19L3,THSD4,ASPG,L1CAM,TSPEAR,GNAO1,EMX2,ABCA5,ZMYM1,FASN,TMEM187,CSMD3,PKD1L2,MAPK4,C1QL1,CD209,SYT12,FUT6,PGK1,DDX20,RRP36,MEGF11,MEGF10,CSRNP3,SUSD2,CACHD1,ANGPT2,TENM3,CUBN,ATL2,ANK1,TNFSF14,BCHE,LRRC74A,WRN,MB21D2,PTPRK,FAT4,MMRN2,THAP2,KIFC1,MMRN1,SLC16A4,POU3F3 88 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities pancreaticobiliary neoplasm Pancreaticobiliary neoplasm 7.04E-06 BIRC2,HDHD5,KRT8,CELSR1,L3HYPDH,CHRNA10,TMPRSS6,TRIM3,PLG,AKNA,TNR,RRM2,TRPM2,TKFC,FGL1,FLNC,SLC5A7,LRP6,HCRTR2,VWDE,HSPA12B,DDO,RNF207,SVEP1,ALDH7A1,PDZD7,TULP4,TPPP3,PTK7,NLGN2,AGA,PTPRG,ABCA3,TNXB,NCAN,RRP12,L1CAM,SCARF2,TSPEAR,SNAP25,EMX2,FASN,CSMD3,MAPK4,DDX20,PGK1,ITGB3,TRIM36,COLEC11,FRRS1,SUSD2,LRP4,CACHD1,ANGPT2,TENM3,TSNARE1,CUBN,ANK1,PPP1CA,BCHE,WRN,POLI,TRIM56,PRKCSH,FAT4,MMRN2,TMEM161B,SLC16A4 68 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities pancreatobiliary tumor Pancreatobiliary tumor 7.04E-06 BIRC2,HDHD5,KRT8,CELSR1,L3HYPDH,CHRNA10,TMPRSS6,TRIM3,PLG,AKNA,TNR,RRM2,TRPM2,TKFC,FGL1,FLNC,SLC5A7,LRP6,HCRTR2,VWDE,HSPA12B,DDO,RNF207,SVEP1,ALDH7A1,PDZD7,TULP4,TPPP3,PTK7,NLGN2,AGA,PTPRG,ABCA3,TNXB,NCAN,RRP12,L1CAM,SCARF2,TSPEAR,SNAP25,EMX2,FASN,CSMD3,MAPK4,DDX20,PGK1,ITGB3,TRIM36,COLEC11,FRRS1,SUSD2,LRP4,CACHD1,ANGPT2,TENM3,TSNARE1,CUBN,ANK1,PPP1CA,BCHE,WRN,POLI,TRIM56,PRKCSH,FAT4,MMRN2,TMEM161B,SLC16A4 68 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease genital tumor Genital tumor 7.29E-06 CELSR1,KRT8,LGMN,CHRNA10,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,LRP6,SNX33,HSPA12B,ITIH6,PTK7,CHAC1,NLGN2,PTPRG,TNXB,ADGRG6,HSD3B2,THSD4,RASEF,ASPG,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CD209,CALCRL,DDX20,MEGF10,FRRS1,TSG101,LRP4,MEGF6,TENM3,BCHE,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN1,BIRC2,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,RABL2B,PGBD4,DDO,RNF207,ANOS1,TRAF3IP2,SVEP1,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,ABCA3,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,DPY19L3,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,FUT6,PGK1,ITGB3,MEGF11,CASP2,TRIM36,COLEC11,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,KMT5A,WRN,PIF1,FAT4,DUT,IFI44,KIFC1,SLC16A4,POU3F3 117 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities neoplasia Neoplasia of leukocytes 7.80E-06 KRT8,CELSR1,LGMN,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,BIRC3,BBX,AKNA,RRM2,SYCE2,FGL1,SLC5A7,LRP6,VWDE,ANOS1,SVEP1,FCGBP,PTK7,PTPRG,TNXB,NCAN,RRP12,ANKRD50,NUBP1,HNRNPM,CR1,L1CAM,TSPEAR,FASN,CSMD3,PKD1L2,CALCRL,PGK1,ITGB3,CASP2,MEGF10,FRRS1,LRP4,CACHD1,CEBPD,MEGF6,ANGPT2,TENM3,TSNARE1,CUBN,ANK1,PPP1CA,ETNK1,BCHE,POLI,PTPRK,SLC16A7,FAT4,MMRN2,IFI44 58 Cancer, Organismal Injury and Abnormalities anogenital cancer Anogenital cancer 7.88E-06 KRT8,CELSR1,LGMN,CHRNA10,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,LRP6,SNX33,HSPA12B,ITIH6,PTK7,CHAC1,NLGN2,PTPRG,TNXB,ADGRG6,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,DDX20,EMILIN2,MEGF10,FRRS1,TSG101,LRP4,MEGF6,TENM3,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN1,BIRC2,CLEC10A,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,RABL2B,PGBD4,DDO,RNF207,ANOS1,TRAF3IP2,SVEP1,ALDH7A1,XPO7,GSTM3,TULP4,ANGPTL3,FCGBP,H2BC21,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,FUT6,PGK1,ITGB3,MEGF11,CASP2,TRIM36,COLEC11,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,ETNK1,KMT5A,ACAA1,WRN,PIF1,FAT4,IFI44,KIFC1,SLC16A4,POU3F3 126 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities tumorigenesis Tumorigenesis of lymphocytes 8.34E-06 KRT8,CELSR1,LGMN,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,BIRC3,BBX,AKNA,RRM2,SYCE2,SLC5A7,LRP6,VWDE,ANOS1,SVEP1,FCGBP,PTK7,PTPRG,TNXB,NCAN,RRP12,ANKRD50,NUBP1,HNRNPM,CR1,L1CAM,TSPEAR,FASN,CSMD3,PKD1L2,CALCRL,PGK1,ITGB3,CASP2,MEGF10,FRRS1,LRP4,CACHD1,CEBPD,MEGF6,ANGPT2,TENM3,TSNARE1,CUBN,ANK1,PPP1CA,BCHE,POLI,PTPRK,SLC16A7,FAT4,MMRN2,IFI44 56 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities B-cell neoplasm B-cell neoplasm 8.72E-06 KRT8,CELSR1,LGMN,CHRNA10,FASN,ADAMTS16,TMPRSS6,TRIM3,BIRC3,BBX,PKD1L2,AKNA,RRM2,SYCE2,CALCRL,PGK1,ITGB3,SLC5A7,LRP6,VWDE,CASP2,MEGF10,FRRS1,LRP4,CACHD1,ANOS1,CEBPD,TENM3,TSNARE1,CUBN,SVEP1,ANK1,PPP1CA,BCHE,FCGBP,PTK7,PTPRK,SLC16A7,FAT4,PTPRG,TNXB,NCAN,ANKRD50,NUBP1,HNRNPM,CR1,L1CAM,TSPEAR 48 Cancer, Organismal Injury and Abnormalities genitourinary tumor Genitourinary tumor 8.73E-06 0.600 0.627 KRT8,CELSR1,LGMN,CHRNA10,TRIM3,GLB1,BIRC3,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,ITIH6,PTK7,CHAC1,NLGN2,PTPRG,TNXB,ADGRG6,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,DDX20,NANOS1,EMILIN2,MEGF10,FRRS1,TSG101,LRP4,MEGF6,TENM3,BCHE,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN1,BIRC2,CLEC10A,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,SLC5A7,ADRM1,HCRTR2,VWDE,RABL2B,PGBD4,DDO,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,TULP4,ANGPTL3,FCGBP,H2BC21,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ABCA5,MFSD1,ZMYM1,LITAF,CSMD3,C1QL1,FUT6,PGK1,ITGB3,MEGF11,CASP2,TRIM36,COLEC11,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,PPP1CA,ETNK1,KMT5A,ACAA1,WRN,PIF1,FAT4,DUT,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 134 Cancer, Hematological Disease, Organismal Injury and Abnormalities neoplasia Neoplasia of blood cells 1.06E-05 CELSR1,KRT8,LGMN,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,BIRC3,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,FGL1,FLNC,SLC5A7,LRP6,VWDE,RABL2B,ANOS1,SVEP1,ALDH7A1,XPO7,TULP4,FCGBP,PTK7,PTPRG,TNXB,NCAN,RRP12,ANKRD50,NUBP1,HNRNPM,RASEF,CR1,L1CAM,TSPEAR,ZMYM1,FASN,CSMD3,PKD1L2,SERINC2,CALCRL,PGK1,ITGB3,EMILIN2,CASP2,MEGF10,FRRS1,SUSD2,LRP4,CACHD1,ANGPT2,CEBPD,MEGF6,TENM3,TSNARE1,CUBN,ATL2,ANK1,PPP1CA,ETNK1,BCHE,KMT5A,POLI,PTPRK,SLC16A7,FAT4,MMRN2,IFI44 72 Cancer, Dermatological Diseases and Conditions, Organismal Injury and Abnormalities skin carcinoma Skin carcinoma 1.06E-05 KRT8,CLEC10A,CELSR1,L3HYPDH,LGMN,CHRNA10,SULT1A2,ADAMTS16,TMPRSS6,TRIM3,GLB1,PLG,BIRC3,AOC1,BBX,TNR,CHRNB3,VWDE,PTGIR,DDO,SVEP1,ITIH6,MGAT4C,PDZD7,TULP4,PTPRG,TNXB,NCAN,ADGRG6,RRP12,SCARF1,ANKRD50,CR1,THSD4,TTC24,L1CAM,TSPEAR,SNAP25,ABCA5,ZMYM1,FASN,FAM234B,CGAS,CSMD3,PKD1L2,DDX20,PGK1,ITGB3,TRIM36,MEGF10,TSG101,CACHD1,MEGF6,TENM3,CUBN,TNFSF14,ETNK1,BCHE,FAM111A,WRN,TRIM56,FAT4,IFI44,MMRN1 64 Cancer, Hematological Disease, Organismal Injury and Abnormalities hematological neoplasia Hematopoietic neoplasm 1.12E-05 CELSR1,KRT8,LGMN,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,BIRC3,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,FGL1,FLNC,SLC5A7,LRP6,VWDE,RABL2B,ANOS1,SVEP1,ALDH7A1,XPO7,TULP4,FCGBP,PTK7,AGA,PTPRG,TNXB,NCAN,RRP12,ANKRD50,NUBP1,HNRNPM,RASEF,CR1,L1CAM,TSPEAR,ABCA5,ZMYM1,FASN,CSMD3,PKD1L2,SERINC2,MAPK4,CALCRL,PGK1,ITGB3,EMILIN2,CASP2,MEGF10,FRRS1,SUSD2,LRP4,CACHD1,ANGPT2,CEBPD,MEGF6,TENM3,TSNARE1,CUBN,ATL2,ANK1,PPP1CA,ETNK1,BCHE,KMT5A,POLI,PTPRK,SLC16A7,FAT4,MMRN2,IFI44 75 Cancer, Hematological Disease, Organismal Injury and Abnormalities hematologic cancer Hematologic cancer 1.16E-05 CELSR1,KRT8,LGMN,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,BIRC3,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,FGL1,FLNC,SLC5A7,LRP6,VWDE,RABL2B,ANOS1,SVEP1,ALDH7A1,XPO7,TULP4,FCGBP,PTK7,PTPRG,TNXB,NCAN,RRP12,ANKRD50,NUBP1,HNRNPM,RASEF,CR1,L1CAM,TSPEAR,ABCA5,ZMYM1,FASN,CSMD3,PKD1L2,SERINC2,MAPK4,CALCRL,PGK1,ITGB3,EMILIN2,CASP2,MEGF10,FRRS1,SUSD2,LRP4,CACHD1,ANGPT2,CEBPD,MEGF6,TENM3,TSNARE1,CUBN,ATL2,ANK1,PPP1CA,ETNK1,BCHE,KMT5A,POLI,PTPRK,SLC16A7,FAT4,MMRN2,IFI44 74 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease female genital tract adenocarcinoma Female genital tract adenocarcinoma 1.21E-05 BIRC2,CELSR1,KRT8,LRP5,LGMN,ADAMTS16,TMPRSS6,TRIM3,GLB1,SLC16A14,AKNA,TNR,RRM2,TRPM2,CHRNB3,TKFC,PNLIP,FLNC,HCRTR2,VWDE,SNX33,RABL2B,HSPA12B,PGBD4,RNF207,ANOS1,TRAF3IP2,SVEP1,ITIH6,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,PTK7,NLGN2,PTPRG,ABCA3,TNXB,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,HSD3B2,RASEF,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,ABCA5,ZMYM1,HARBI1,FAM234B,CGAS,CSMD3,MAPK4,CD209,CALCRL,PGK1,DDX20,ITGB3,CASP2,MEGF10,TRIM36,COLEC11,FRRS1,LRP4,CACHD1,ANGPT2,MEGF6,TENM3,TSNARE1,CUBN,LRRC74A,POLI,TRIM56,PTPRK,SLC16A7,FAT4,IFI44,KIFC1,MMRN1,SLC16A4,POU3F3 88 Cancer, Organismal Injury and Abnormalities pelvic carcinoma Pelvic carcinoma 1.24E-05 CELSR1,KRT8,LGMN,CHRNA10,TRIM3,GLB1,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,ITIH6,PDZD7,PTK7,NLGN2,PTPRG,TNXB,ADGRG6,HSD3B2,THSD4,RASEF,ASPG,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CD209,CALCRL,DDX20,EMILIN2,MEGF10,FRRS1,TSG101,LRP4,MEGF6,TENM3,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN1,BIRC2,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,HCRTR2,VWDE,RABL2B,PGBD4,DDO,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,ABCA3,NCAN,RRP12,C1QTNF4,ANKRD50,NUBP1,HNRNPM,DPY19L3,ABCA5,ZMYM1,LITAF,CSMD3,C1QL1,PGK1,ITGB3,MEGF11,CASP2,TRIM36,COLEC11,CACHD1,ANGPT2,CEBPD,TSNARE1,CUBN,ANK1,PPP1CA,KMT5A,WRN,FAT4,IFI44,KIFC1,SLC16A4,POU3F3 116 Cancer, Organismal Injury and Abnormalities neoplasia Lymphatic system tumor 1.33E-05 KRT8,CELSR1,LGMN,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,BIRC3,BBX,AKNA,RRM2,SYCE2,FGL1,SLC5A7,LRP6,VWDE,ANOS1,SVEP1,FCGBP,PTK7,PTPRG,TNXB,NCAN,ADGRG6,RRP12,ANKRD50,NUBP1,HNRNPM,CR1,L1CAM,TSPEAR,ABCA5,FASN,CGAS,CSMD3,PKD1L2,MAPK4,CALCRL,PGK1,ITGB3,CASP2,MEGF10,FRRS1,LRP4,CACHD1,CEBPD,MEGF6,ANGPT2,TENM3,TSNARE1,CUBN,ANK1,PPP1CA,BCHE,POLI,PTPRK,SLC16A7,FAT4,MMRN2,IFI44 61 Cancer, Hematological Disease, Organismal Injury and Abnormalities myeloid or lymphoid neoplasm Myeloid or lymphoid neoplasm 1.54E-05 CELSR1,KRT8,LGMN,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,BIRC3,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,FGL1,FLNC,SLC5A7,LRP6,VWDE,RABL2B,ANOS1,SVEP1,ALDH7A1,XPO7,TULP4,FCGBP,PTK7,PTPRG,TNXB,NCAN,RRP12,ANKRD50,NUBP1,HNRNPM,RASEF,CR1,L1CAM,TSPEAR,ABCA5,ZMYM1,FASN,CSMD3,PKD1L2,SERINC2,MAPK4,CALCRL,PGK1,ITGB3,EMILIN2,CASP2,MEGF10,FRRS1,SUSD2,LRP4,CACHD1,ANGPT2,CEBPD,MEGF6,TENM3,TSNARE1,CUBN,ATL2,ANK1,PPP1CA,ETNK1,BCHE,KMT5A,POLI,PTPRK,SLC16A7,FAT4,MMRN2,IFI44 74 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities gastroesophageal adenocarcinoma Gastroesophageal adenocarcinoma 1.55E-05 HDHD5,LRP5,CHRNA10,ADAMTS16,TMPRSS6,BIRC3,AKNA,FLNC,LRP6,HCRTR2,VWDE,PTGIR,DDO,ANOS1,TRAF3IP2,SVEP1,XPO7,CLPB,CACFD1,TULP4,FCGBP,NLGN2,PTPRG,TNXB,NCAN,SCARF1,DPY19L3,CR1,THSD4,TSPEAR,CALM1 (includes others),FASN,CSMD3,SERINC2,C1QL1,RRP36,CASP2,COLEC11,MEGF6,ANGPT2,TENM3,CUBN,ANK1,BCHE,KMT5A,ACAA1,FAM111A,WRN,PTPRK,FAT4,TMEM161B,SLC16A4 52 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease female genital carcinoma Female genital carcinoma 1.59E-05 BIRC2,CELSR1,KRT8,LRP5,LGMN,ADAMTS16,TMPRSS6,TRIM3,GLB1,SLC16A14,AKNA,TNR,RRM2,TRPM2,CHRNB3,TKFC,PNLIP,FLNC,HCRTR2,VWDE,SNX33,RABL2B,HSPA12B,PGBD4,RNF207,ANOS1,TRAF3IP2,SVEP1,ITIH6,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,PTK7,NLGN2,PTPRG,ABCA3,TNXB,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,HSD3B2,RASEF,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,ABCA5,ZMYM1,HARBI1,FAM234B,CGAS,CSMD3,PKD1L2,MAPK4,CD209,CALCRL,PGK1,DDX20,ITGB3,CASP2,MEGF10,TRIM36,COLEC11,FRRS1,TSG101,LRP4,CACHD1,ANGPT2,MEGF6,TENM3,TSNARE1,CUBN,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,FAT4,IFI44,KIFC1,MMRN1,SLC16A4,POU3F3 91 Cancer, Hematological Disease, Organismal Injury and Abnormalities hematologic cancer Hematologic cancer of cells 1.78E-05 KRT8,CELSR1,LGMN,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,BIRC3,BBX,AKNA,RRM2,SYCE2,FGL1,SLC5A7,LRP6,VWDE,ANOS1,SVEP1,FCGBP,PTK7,PTPRG,TNXB,NCAN,RRP12,ANKRD50,NUBP1,HNRNPM,L1CAM,TSPEAR,FASN,CSMD3,PKD1L2,CALCRL,PGK1,ITGB3,CASP2,MEGF10,LRP4,CACHD1,MEGF6,ANGPT2,TENM3,TSNARE1,CUBN,ANK1,PPP1CA,BCHE,POLI,PTPRK,SLC16A7,FAT4,MMRN2,IFI44 54 Cancer, Organismal Injury and Abnormalities, Respiratory Disease malignant neoplasm of respiratory system Malignant neoplasm of respiratory system 1.95E-05 0.000 0.013 CELSR1,KRT8,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,TRIM3,PLG,AOC1,TNR,RRM2,TRPM2,CHRNB3,TKFC,PNLIP,FGL1,AIMP2,FLNC,SLC5A7,LRP6,ADRM1,VWDE,PGBD4,REG1A,ANOS1,SVEP1,MGAT4C,CLPB,PDZD7,TULP4,ANGPTL3,PTK7,NLGN2,AGA,TNXB,NCAN,ADGRG6,RRP12,ANKRD50,DPY19L3,THSD4,ASPG,CR1,L1CAM,SCARF2,TSPEAR,ZSWIM9,GNAO1,EMX2,ABCA5,FASN,TMEM187,CGAS,CSMD3,PKD1L2,SERINC2,CD209,TRIM2,PGK1,DDX20,FIBCD1,ITGB3,MEGF11,EMILIN2,CASP2,TSG101,FRRS1,ANGPT2,TENM3,TSNARE1,CUBN,BCHE,KMT5A,PLIN2,LRRC74A,WRN,POLI,MB21D2,PRKCSH,FAT4,IFI44,MMRN1,TMEM161B,POU3F3 84 Cancer, Organismal Injury and Abnormalities, Respiratory Disease lung cancer Lung cancer 2.04E-05 0.000 0.011 CELSR1,KRT8,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,TRIM3,PLG,AOC1,TNR,RRM2,TRPM2,CHRNB3,TKFC,PNLIP,FGL1,AIMP2,FLNC,SLC5A7,ADRM1,VWDE,REG1A,ANOS1,SVEP1,MGAT4C,CLPB,PDZD7,TULP4,ANGPTL3,PTK7,NLGN2,AGA,TNXB,NCAN,ADGRG6,RRP12,DPY19L3,ASPG,CR1,L1CAM,SCARF2,TSPEAR,ZSWIM9,GNAO1,EMX2,ABCA5,FASN,TMEM187,CGAS,CSMD3,PKD1L2,SERINC2,TRIM2,PGK1,DDX20,FIBCD1,ITGB3,MEGF11,EMILIN2,CASP2,FRRS1,TSG101,ANGPT2,TENM3,TSNARE1,CUBN,BCHE,PLIN2,LRRC74A,WRN,POLI,MB21D2,PRKCSH,FAT4,IFI44,MMRN1,TMEM161B,POU3F3 78 Lipid Metabolism, Small Molecule Biochemistry incorporation Incorporation of lipid 2.56E-05 0.181 0.334 ABCA3,ETNK1,FASN,DGAT1,PLIN2 5 Cancer, Dermatological Diseases and Conditions, Organismal Injury and Abnormalities skin basal cell carcinoma Basal cell carcinoma 2.93E-05 KRT8,CLEC10A,CELSR1,L3HYPDH,LGMN,CHRNA10,SULT1A2,ADAMTS16,TMPRSS6,TRIM3,GLB1,PLG,BIRC3,AOC1,BBX,TNR,CHRNB3,VWDE,PTGIR,DDO,SVEP1,ITIH6,MGAT4C,TULP4,PTPRG,TNXB,NCAN,ADGRG6,RRP12,SCARF1,ANKRD50,CR1,THSD4,L1CAM,TSPEAR,ABCA5,ZMYM1,FAM234B,CGAS,CSMD3,PKD1L2,DDX20,PGK1,ITGB3,TRIM36,CACHD1,MEGF6,TENM3,CUBN,ETNK1,BCHE,FAM111A,WRN,TRIM56,FAT4,IFI44,MMRN1 57 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities lymphocytic cancer Lymphocytic cancer 3.30E-05 KRT8,CELSR1,LGMN,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,BIRC3,BBX,AKNA,RRM2,SYCE2,FGL1,SLC5A7,LRP6,VWDE,ANOS1,SVEP1,FCGBP,PTK7,PTPRG,TNXB,NCAN,RRP12,ANKRD50,NUBP1,HNRNPM,CR1,L1CAM,TSPEAR,ABCA5,FASN,CSMD3,PKD1L2,MAPK4,CALCRL,PGK1,ITGB3,CASP2,MEGF10,FRRS1,LRP4,CACHD1,CEBPD,MEGF6,ANGPT2,TENM3,TSNARE1,CUBN,ANK1,PPP1CA,BCHE,POLI,PTPRK,SLC16A7,FAT4,MMRN2,IFI44 59 Cancer, Hematological Disease, Organismal Injury and Abnormalities malignant lymphocytic neoplasm Malignant lymphocytic neoplasm 3.30E-05 KRT8,CELSR1,LGMN,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,BIRC3,BBX,AKNA,RRM2,SYCE2,FGL1,SLC5A7,LRP6,VWDE,ANOS1,SVEP1,FCGBP,PTK7,PTPRG,TNXB,NCAN,RRP12,ANKRD50,NUBP1,HNRNPM,CR1,L1CAM,TSPEAR,ABCA5,FASN,CSMD3,PKD1L2,MAPK4,CALCRL,PGK1,ITGB3,CASP2,MEGF10,FRRS1,LRP4,CACHD1,CEBPD,MEGF6,ANGPT2,TENM3,TSNARE1,CUBN,ANK1,PPP1CA,BCHE,POLI,PTPRK,SLC16A7,FAT4,MMRN2,IFI44 59 Organismal Development morphology Morphology of body cavity 3.59E-05 BIRC2,KRT8,LRP5,LGMN,EMX2,ABCA5,MFSD1,FASN,DGAT1,TMPRSS6,LITAF,PLG,B4GALT1,BIRC3,RRM2,TRPM2,CALCRL,PNLIP,PGK1,FGL1,ITGB3,FLNC,LRP6,CASP2,PTGIR,COLEC11,REG1A,FRRS1,TSG101,LRP4,ANGPT2,TRAF3IP2,TNFSF14,PPP1CA,ANGPTL3,NLGN2,AGA,FAT4,ABCA3,SCARF1,POU3F3 41 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities gastro-esophageal carcinoma Gastro-esophageal carcinoma 3.63E-05 HDHD5,CELSR1,LRP5,L3HYPDH,LGMN,CHRNA10,ADAMTS16,TMPRSS6,BIRC3,AOC1,AKNA,TNR,FLNC,LRP6,HCRTR2,VWDE,PTGIR,DDO,ANOS1,TRAF3IP2,SVEP1,MGAT4C,CLPB,XPO7,PDZD7,CACFD1,TULP4,FCGBP,NLGN2,CCDC13,PTPRG,TNXB,NCAN,SCARF1,C1QTNF4,DPY19L3,THSD4,CR1,SCARF2,TSPEAR,ZSWIM9,CALM1 (includes others),ABCA5,FASN,CSMD3,PKD1L2,SERINC2,C1QL1,CD209,RRP36,CASP2,MEGF10,COLEC11,CACHD1,ANGPT2,MEGF6,TENM3,CUBN,ANK1,BCHE,ACAA1,KMT5A,PLIN2,FAM111A,WRN,POLI,PTPRK,FAT4,MMRN1,TMEM161B,SLC16A4,POU3F3 72 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities gastroesophageal cancer Gastroesophageal cancer 3.97E-05 HDHD5,CELSR1,LRP5,L3HYPDH,LGMN,CHRNA10,ADAMTS16,TMPRSS6,PLG,BIRC3,AOC1,AKNA,TNR,RRM2,FLNC,LRP6,HCRTR2,VWDE,PTGIR,DDO,ANOS1,TRAF3IP2,SVEP1,MGAT4C,CLPB,XPO7,PDZD7,CACFD1,TULP4,FCGBP,NLGN2,CCDC13,PTPRG,TNXB,NCAN,SCARF1,C1QTNF4,DPY19L3,THSD4,CR1,SCARF2,TSPEAR,ZSWIM9,CALM1 (includes others),ABCA5,FASN,CSMD3,PKD1L2,SERINC2,C1QL1,CD209,RRP36,CASP2,MEGF10,COLEC11,CACHD1,ANGPT2,MEGF6,TENM3,CUBN,ANK1,BCHE,ACAA1,KMT5A,PLIN2,FAM111A,WRN,POLI,PTPRK,FAT4,MMRN1,TMEM161B,SLC16A4,POU3F3 74 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities pancreatobiliary adenocarcinoma Pancreatobiliary adenocarcinoma 4.23E-05 BIRC2,HDHD5,CELSR1,TMPRSS6,TRIM3,TNR,RRM2,TRPM2,TKFC,FGL1,FLNC,SLC5A7,VWDE,HSPA12B,DDO,RNF207,SVEP1,ALDH7A1,TPPP3,PTK7,NLGN2,PTPRG,ABCA3,TNXB,NCAN,RRP12,L1CAM,TSPEAR,SNAP25,EMX2,FASN,CSMD3,DDX20,PGK1,ITGB3,TRIM36,COLEC11,FRRS1,SUSD2,CACHD1,ANGPT2,TENM3,CUBN,ANK1,BCHE,WRN,POLI,TRIM56,PRKCSH,FAT4,TMEM161B,SLC16A4 52 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease genital carcinoma Genital carcinoma 4.45E-05 CELSR1,KRT8,LGMN,CHRNA10,TRIM3,GLB1,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,LRP6,SNX33,HSPA12B,ITIH6,PTK7,NLGN2,PTPRG,TNXB,ADGRG6,HSD3B2,THSD4,RASEF,ASPG,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,MAPK4,CD209,CALCRL,DDX20,MEGF10,FRRS1,TSG101,LRP4,MEGF6,TENM3,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN1,BIRC2,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,HCRTR2,VWDE,RABL2B,PGBD4,DDO,RNF207,ANOS1,TRAF3IP2,SVEP1,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,ABCA3,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,DPY19L3,ABCA5,ZMYM1,LITAF,CSMD3,PGK1,ITGB3,MEGF11,CASP2,TRIM36,COLEC11,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,KMT5A,WRN,FAT4,IFI44,KIFC1,SLC16A4,POU3F3 107 Hematological System Development and Function, Immunological Disease, Inflammatory Disease, Lymphoid Tissue Structure and Development, Organ Morphology, Organismal Development, Organismal Injury and Abnormalities, Tissue Morphology enlargement Enlargement of spleen 4.56E-05 KRT8,RRM2,TRAF3IP2,LGMN,TNFSF14,ITGB3,TMPRSS6,SCARF1,PLG,PTGIR,B4GALT1 11 Carbohydrate Metabolism incorporation Incorporation of carbohydrate 4.63E-05 ABCA3,ETNK1,FASN,DGAT1 4 Cellular Assembly and Organization, Cellular Function and Maintenance release Release of extracellular vesicles 4.63E-05 -1.941 -1.786 RAB11A,SNAP25,ABCA3,ITGB3 4 Cancer, Organismal Injury and Abnormalities, Respiratory Disease carcinoma Lung carcinoma 5.08E-05 CELSR1,KRT8,LRP5,L3HYPDH,ADAMTS16,TMPRSS6,TRIM3,PLG,AOC1,TNR,RRM2,TRPM2,CHRNB3,TKFC,PNLIP,FGL1,FLNC,SLC5A7,ADRM1,VWDE,REG1A,ANOS1,SVEP1,MGAT4C,CLPB,PDZD7,TULP4,ANGPTL3,PTK7,NLGN2,AGA,TNXB,NCAN,ADGRG6,RRP12,DPY19L3,ASPG,CR1,L1CAM,SCARF2,TSPEAR,ZSWIM9,GNAO1,ABCA5,FASN,TMEM187,CGAS,CSMD3,PKD1L2,SERINC2,TRIM2,PGK1,FIBCD1,MEGF11,EMILIN2,CASP2,FRRS1,TSG101,ANGPT2,TENM3,TSNARE1,CUBN,BCHE,PLIN2,LRRC74A,WRN,POLI,MB21D2,PRKCSH,FAT4,IFI44,MMRN1,TMEM161B,POU3F3 74 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease uterine cancer Uterine cancer 5.52E-05 BIRC2,CELSR1,KRT8,LRP5,LGMN,ADAMTS16,TMPRSS6,TRIM3,PLG,BIRC3,SLC16A14,TNR,RRM2,TRPM2,CHRNB3,TKFC,PNLIP,FLNC,HCRTR2,VWDE,SNX33,RABL2B,PGBD4,RNF207,ANOS1,TRAF3IP2,SVEP1,ITIH6,XPO7,TULP4,ANGPTL3,FCGBP,NLGN2,ABCA3,TNXB,C1QTNF4,ANKRD50,NUBP1,THSD4,RASEF,CR1,L1CAM,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,ABCA5,MFSD1,ZMYM1,HARBI1,CGAS,CSMD3,SERINC2,MAPK4,CD209,CALCRL,PGK1,DDX20,ITGB3,MEGF10,COLEC11,FRRS1,LRP4,CACHD1,ANGPT2,MEGF6,TENM3,TSNARE1,CUBN,ANK1,BCHE,LRRC74A,POLI,PIF1,TRIM56,MB21D2,PTPRK,SLC16A7,FAT4,IFI44,KIFC1,MMRN1,SLC16A4,POU3F3 84 Embryonic Development, Organismal Development, Tissue Development, Tissue Morphology expansion Expansion of primitive streak 6.02E-05 LRP5,LRP6 2 Cell-mediated Immune Response, Lymphoid Tissue Structure and Development frequency Frequency of Tr1 cells 6.02E-05 LRP5,LRP6 2 Developmental Disorder, Embryonic Development, Organismal Development, Organismal Injury and Abnormalities, Tissue Morphology loss Loss of paraxial mesoderm 6.02E-05 LRP5,LRP6 2 Cellular Development, Cellular Growth and Proliferation, Embryonic Development, Organismal Development, Tissue Development proliferation Proliferation of extravillous cytotrophoblasts 6.02E-05 LRP5,LRP6 2 Cellular Assembly and Organization, Cellular Function and Maintenance formation Formation of multivesicular bodies 6.27E-05 TSG101,RAB11A,LITAF,VPS25 4 Cancer, Organismal Injury and Abnormalities breast or pancreatic cancer Breast or pancreatic cancer 6.41E-05 BIRC2,CLEC10A,CELSR1,KRT8,LRP5,TMPRSS6,TRIM3,GLB1,PLG,AOC1,AKNA,TNR,RRM2,TRPM2,CHRNB3,TKFC,FLNC,SLC5A7,LRP6,ADRM1,HCRTR2,VWDE,HSPA12B,RNF207,SVEP1,ALDH7A1,GSTM3,XPO7,PDZD7,TULP4,TPPP3,FCGBP,PTK7,NLGN2,H2BC21,PTPRG,ABCA3,TNXB,NCAN,ADGRG6,RRP12,ANKRD50,NUBP1,HNRNPM,HSD3B2,THSD4,RASEF,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),EMX2,ZMYM1,FASN,FAM234B,CSMD3,PKD1L2,MAPK4,PGK1,DDX20,ITGB3,EMILIN2,CASP2,TRIM36,COLEC11,FRRS1,SUSD2,TSG101,LRP4,CACHD1,ANGPT2,CEBPD,TENM3,CUBN,ANK1,PPP1CA,ETNK1,BCHE,ACAA1,KMT5A,PLIN2,FAM111A,WRN,POLI,TRIM56,MB21D2,PRKCSH,PTPRK,FAT4,KIFC1,TMEM161B,SLC16A4 92 Cancer, Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities biliary tract carcinoma Biliary tract carcinoma 6.59E-05 HDHD5,KRT8,CELSR1,L3HYPDH,SNAP25,TMPRSS6,CSMD3,AKNA,RRM2,DDX20,PGK1,FGL1,LRP6,HSPA12B,DDO,CACHD1,LRP4,TENM3,TSNARE1,SVEP1,ALDH7A1,TULP4,AGA,FAT4,TMEM161B,L1CAM,SCARF2 27 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities gastric epithelial cancer Gastric carcinoma 6.71E-05 CELSR1,LRP5,L3HYPDH,LGMN,CHRNA10,ADAMTS16,TMPRSS6,BIRC3,AOC1,AKNA,TNR,FLNC,LRP6,HCRTR2,VWDE,PTGIR,DDO,ANOS1,TRAF3IP2,SVEP1,MGAT4C,XPO7,PDZD7,CACFD1,TULP4,FCGBP,NLGN2,CCDC13,PTPRG,TNXB,SCARF1,C1QTNF4,DPY19L3,CR1,THSD4,SCARF2,ZSWIM9,CALM1 (includes others),ABCA5,FASN,CSMD3,PKD1L2,SERINC2,C1QL1,CD209,RRP36,CASP2,MEGF10,CACHD1,MEGF6,ANGPT2,TENM3,CUBN,ANK1,BCHE,KMT5A,ACAA1,PLIN2,FAM111A,WRN,POLI,PTPRK,FAT4,MMRN1,TMEM161B,SLC16A4,POU3F3 67 Cancer, Organismal Injury and Abnormalities lymphoreticular neoplasm Lymphoreticular neoplasm 7.32E-05 LGMN,ADAMTS16,TMPRSS6,PLG,BIRC3,BBX,TNR,RRM2,CHRNB3,SYCE2,FLNC,SLC5A7,LRP6,VWDE,RABL2B,ANOS1,SVEP1,ALDH7A1,XPO7,TULP4,FCGBP,PTK7,TNXB,NCAN,RRP12,ANKRD50,NUBP1,HNRNPM,RASEF,CR1,L1CAM,TSPEAR,ZMYM1,FASN,CGAS,CSMD3,SERINC2,CALCRL,PGK1,ITGB3,EMILIN2,CASP2,SUSD2,CEBPD,MEGF6,ANGPT2,TENM3,CUBN,ATL2,ETNK1,BCHE,KMT5A,POLI,PTPRK,SLC16A7,FAT4,MMRN2,IFI44 58 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities gastric cancer Gastric cancer 7.78E-05 CELSR1,LRP5,L3HYPDH,LGMN,CHRNA10,ADAMTS16,TMPRSS6,PLG,BIRC3,AOC1,AKNA,TNR,RRM2,FLNC,LRP6,HCRTR2,VWDE,PTGIR,DDO,ANOS1,TRAF3IP2,SVEP1,MGAT4C,XPO7,PDZD7,CACFD1,TULP4,FCGBP,NLGN2,CCDC13,PTPRG,TNXB,SCARF1,C1QTNF4,DPY19L3,CR1,THSD4,SCARF2,ZSWIM9,CALM1 (includes others),ABCA5,FASN,CSMD3,PKD1L2,SERINC2,C1QL1,CD209,RRP36,CASP2,MEGF10,CACHD1,MEGF6,ANGPT2,TENM3,CUBN,ANK1,BCHE,KMT5A,ACAA1,PLIN2,FAM111A,WRN,POLI,PTPRK,FAT4,MMRN1,TMEM161B,SLC16A4,POU3F3 69 Organismal Injury and Abnormalities, Renal and Urological Disease formation Formation of renal lesion 7.99E-05 KRT8,LGMN,CHRNA10,TMPRSS6,CSMD3,GLB1,PKD1L2,SERINC2,AKNA,TNR,RRM2,TRPM2,TKFC,CALCRL,ITGB3,FLNC,CASP2,CUBN,ANK1,ALDH7A1,GSTM3,PLIN2,WRN,PTK7,POLI,FAT4,THAP2,NCAN,NUBP1,HNRNPM,TMEM161B,CR1,L1CAM,TSPEAR 34 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities mature B-cell neoplasm Mature B-cell neoplasm 8.29E-05 KRT8,CELSR1,LGMN,FASN,ADAMTS16,TRIM3,BIRC3,PKD1L2,AKNA,RRM2,CALCRL,PGK1,ITGB3,SLC5A7,LRP6,VWDE,MEGF10,CASP2,FRRS1,LRP4,CEBPD,CUBN,SVEP1,PPP1CA,BCHE,PTK7,PTPRK,FAT4,TNXB,NCAN,ANKRD50,NUBP1,HNRNPM,CR1,L1CAM,TSPEAR 36 Cancer, Organismal Injury and Abnormalities ductal carcinoma Ductal carcinoma 8.54E-05 BIRC2,HDHD5,KRT8,CLEC10A,CELSR1,L3HYPDH,TMPRSS6,TRIM3,AKNA,TNR,RRM2,TRPM2,TKFC,FLNC,SLC5A7,LRP6,VWDE,HSPA12B,RNF207,SVEP1,ALDH7A1,TULP4,TPPP3,PTK7,NLGN2,AGA,PTPRG,ABCA3,TNXB,NCAN,ADGRG6,RRP12,SCARF2,TSPEAR,CALM1 (includes others),EMX2,FASN,CSMD3,DDX20,PGK1,ITGB3,TRIM36,COLEC11,FRRS1,SUSD2,LRP4,ANGPT2,TENM3,TSNARE1,CUBN,ANK1,BCHE,KMT5A,WRN,POLI,TRIM56,PRKCSH,FAT4,KIFC1,TMEM161B,SLC16A4 61 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease uterine tumor Uterine tumor 8.55E-05 BIRC2,CELSR1,KRT8,LRP5,LGMN,ADAMTS16,TMPRSS6,TRIM3,PLG,BIRC3,SLC16A14,TNR,RRM2,TRPM2,CHRNB3,TKFC,PNLIP,FLNC,HCRTR2,VWDE,SNX33,RABL2B,PGBD4,RNF207,ANOS1,TRAF3IP2,ITIH6,SVEP1,XPO7,TULP4,ANGPTL3,FCGBP,NLGN2,ABCA3,TNXB,C1QTNF4,ANKRD50,NUBP1,THSD4,RASEF,CR1,L1CAM,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,ABCA5,MFSD1,ZMYM1,HARBI1,CGAS,CSMD3,SERINC2,MAPK4,CD209,CALCRL,PGK1,DDX20,ITGB3,MEGF10,COLEC11,FRRS1,LRP4,CACHD1,ANGPT2,MEGF6,TENM3,TSNARE1,CUBN,ANK1,BCHE,LRRC74A,POLI,PIF1,TRIM56,MB21D2,PTPRK,SLC16A7,FAT4,DUT,IFI44,KIFC1,MMRN1,SLC16A4,POU3F3 85 Cancer, Organismal Injury and Abnormalities, Respiratory Disease non-small cell lung cancer Non-small cell lung carcinoma 9.03E-05 KRT8,LRP5,L3HYPDH,AOC1,TNR,RRM2,TRPM2,CHRNB3,PNLIP,FGL1,FLNC,SLC5A7,VWDE,REG1A,SVEP1,MGAT4C,CLPB,TULP4,ANGPTL3,PTK7,NLGN2,AGA,TNXB,NCAN,ADGRG6,RRP12,DPY19L3,CR1,L1CAM,TSPEAR,GNAO1,ABCA5,FASN,CGAS,CSMD3,SERINC2,TRIM2,FIBCD1,MEGF11,CASP2,FRRS1,TENM3,TSNARE1,CUBN,BCHE,PLIN2,LRRC74A,WRN,MB21D2,FAT4,MMRN1,TMEM161B 52 Cancer, Organismal Injury and Abnormalities pelvic adenocarcinoma Pelvic adenocarcinoma 9.25E-05 CELSR1,KRT8,LGMN,CHRNA10,TRIM3,GLB1,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,LRP6,SNX33,HSPA12B,ITIH6,PDZD7,PTK7,NLGN2,PTPRG,TNXB,ADGRG6,HSD3B2,THSD4,RASEF,ASPG,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,FASN,HARBI1,FAM234B,CGAS,MAPK4,CD209,CALCRL,DDX20,MEGF10,FRRS1,LRP4,MEGF6,TENM3,LRRC74A,POLI,TRIM56,PTPRK,SLC16A7,MMRN1,BIRC2,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,HCRTR2,VWDE,RABL2B,PGBD4,DDO,RNF207,ANOS1,TRAF3IP2,SVEP1,ALDH7A1,XPO7,TULP4,ANGPTL3,FCGBP,ABCA3,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,DPY19L3,ABCA5,ZMYM1,LITAF,CSMD3,PGK1,ITGB3,MEGF11,CASP2,TRIM36,COLEC11,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,KMT5A,WRN,FAT4,IFI44,KIFC1,SLC16A4,POU3F3 104 Organismal Injury and Abnormalities, Renal and Urological Disease vesicoureteral reflux Vesicoureteral reflux 9.67E-05 BIRC2,EMX2,TNXB 3 Cell-To-Cell Signaling and Interaction, Nervous System Development and Function neurotransmission Neurotransmission 9.88E-05 0.000 0.081 LRP4,CALM1 (includes others),LGMN,SNAP25,CHRNA10,GNAO1,BCHE,P2rx7,NLGN2,TNR,LRP6,SLC5A7,HCRTR2,TMEM161B,L1CAM 15 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease endometrial cancer Endometrial cancer 1.02E-04 BIRC2,CELSR1,KRT8,LRP5,LGMN,ADAMTS16,TMPRSS6,TRIM3,PLG,SLC16A14,TNR,TRPM2,CHRNB3,TKFC,PNLIP,FLNC,HCRTR2,VWDE,SNX33,RABL2B,PGBD4,RNF207,ANOS1,TRAF3IP2,SVEP1,ITIH6,XPO7,TULP4,ANGPTL3,FCGBP,NLGN2,ABCA3,TNXB,C1QTNF4,ANKRD50,NUBP1,RASEF,CR1,L1CAM,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,ABCA5,MFSD1,ZMYM1,HARBI1,CGAS,CSMD3,SERINC2,MAPK4,CD209,CALCRL,PGK1,DDX20,ITGB3,MEGF10,COLEC11,FRRS1,LRP4,CACHD1,ANGPT2,MEGF6,TENM3,TSNARE1,CUBN,ANK1,LRRC74A,POLI,PIF1,TRIM56,PTPRK,SLC16A7,FAT4,IFI44,KIFC1,MMRN1,SLC16A4,POU3F3 79 Cancer, Organismal Injury and Abnormalities head and neck squamous cell cancer Head and neck squamous cell carcinoma 1.06E-04 KRT8,LRP5,TRIM3,TNR,RRM2,TRPM2,CHRNB3,FLNC,SLC5A7,LRP6,HCRTR2,VWDE,MATR3,SVEP1,ITIH6,PDZD7,TULP4,FCGBP,PTK7,NLGN2,SOD3,TNXB,ANKRD50,HNRNPM,CR1,THSD4,L1CAM,SCARF2,TSPEAR,SNAP25,GNAO1,FASN,HARBI1,CSMD3,PKD1L2,SERINC2,PGK1,EMILIN2,MEGF10,CSRNP3,FRRS1,LRP4,MEGF6,CUBN,PPP1CA,KMT5A,WRN,POLI,MB21D2,TRIM56,PRKCSH,FAT4,TMEM161B 53 Cancer, Organismal Injury and Abnormalities neoplasia Neoplasia of cells 1.09E-04 Decreased -2.227 -2.129 CELSR1,KRT8,LGMN,CHRNA10,TRIM3,BIRC3,TRPM2,TKFC,FGL1,LRP6,MATR3,ITIH6,PDZD7,PTK7,NLGN2,AGA,PTPRG,TNXB,THSD4,RASEF,CR1,TTC24,L1CAM,SCARF2,TSPEAR,SNAP25,GNAO1,FASN,HARBI1,PKD1L2,SERINC2,CALCRL,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,ATL2,BCHE,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN2,LRP5,ADAMTS16,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,CHRNB3,SYCE2,FLNC,SLC5A7,HCRTR2,VWDE,PTGIR,RABL2B,ANOS1,SVEP1,ALDH7A1,XPO7,TULP4,FCGBP,SOD3,NCAN,RRP12,ANKRD50,NUBP1,HNRNPM,ZMYM1,CSMD3,FUT6,PGK1,ITGB3,MEGF11,CASP2,SUSD2,CACHD1,ANGPT2,CEBPD,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,ETNK1,KMT5A,WRN,PRKCSH,FAT4,IFI44,KIFC1,TMEM161B 100 Cancer, Organismal Injury and Abnormalities upper aerodigestive tract carcinoma Upper aerodigestive tract carcinoma 1.12E-04 HDHD5,SNAP25,GNAO1,FASN,HARBI1,ADAMTS16,CSMD3,TRIM3,SERINC2,TNR,RRM2,TRPM2,CHRNB3,CD209,PGK1,LRP6,VWDE,EMILIN2,CASP2,MEGF10,PTGIR,MATR3,COLEC11,PGBD4,FRRS1,LRP4,TRAF3IP2,CUBN,SVEP1,PPP1CA,CLPB,BCHE,KMT5A,TULP4,WRN,POLI,NLGN2,SOD3,PRKCSH,FAT4,PTPRG,NCAN,MMRN1,ANKRD50,HNRNPM,TMEM161B,THSD4,L1CAM 48 Cancer, Organismal Injury and Abnormalities malignant neoplasm of retroperitoneum Malignant neoplasm of retroperitoneum 1.25E-04 BIRC2,KRT8,CELSR1,CHRNA10,TMPRSS6,TRIM3,GLB1,PLG,AKNA,TNR,RRM2,TRPM2,TKFC,FLNC,SLC5A7,HCRTR2,VWDE,RNF207,ALDH7A1,PDZD7,GSTM3,TPPP3,PTK7,NLGN2,PTPRG,ABCA3,TNXB,NCAN,RRP12,NUBP1,HNRNPM,CR1,L1CAM,TSPEAR,EMX2,FASN,CSMD3,PKD1L2,SERINC2,CALCRL,DDX20,PGK1,ITGB3,NANOS1,TRIM36,CASP2,COLEC11,FRRS1,SUSD2,ANGPT2,TENM3,CUBN,ANK1,PPP1CA,BCHE,PLIN2,WRN,POLI,TRIM56,PRKCSH,FAT4,THAP2,TMEM161B,SLC16A4 64 Cancer, Organismal Injury and Abnormalities genitourinary adenocarcinoma Genitourinary adenocarcinoma 1.29E-04 CELSR1,KRT8,LGMN,CHRNA10,TRIM3,GLB1,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,LRP6,SNX33,HSPA12B,ITIH6,PTK7,NLGN2,PTPRG,TNXB,ADGRG6,HSD3B2,THSD4,RASEF,ASPG,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,FASN,HARBI1,FAM234B,CGAS,PKD1L2,SERINC2,MAPK4,CD209,CALCRL,DDX20,MEGF10,FRRS1,LRP4,MEGF6,TENM3,PLIN2,LRRC74A,POLI,TRIM56,PTPRK,SLC16A7,MMRN1,BIRC2,CLEC10A,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,HCRTR2,VWDE,RABL2B,PGBD4,DDO,RNF207,ANOS1,TRAF3IP2,SVEP1,ALDH7A1,GSTM3,XPO7,TULP4,ANGPTL3,FCGBP,ABCA3,NCAN,C1QTNF4,ANKRD50,NUBP1,HNRNPM,DPY19L3,ABCA5,ZMYM1,LITAF,CSMD3,PGK1,ITGB3,MEGF11,CASP2,TRIM36,COLEC11,CACHD1,ANGPT2,TSNARE1,CUBN,ANK1,KMT5A,WRN,FAT4,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 110 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities colorectal cancer Colorectal cancer 1.37E-04 CELSR1,KRT8,LRP5,L3HYPDH,SULT1A2,ADAMTS16,TMPRSS6,TRIM3,GLB1,PLG,AOC1,TNR,RRM2,TRPM2,CHRNB3,FGL1,LRP6,HCRTR2,VWDE,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ARL6IP4,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,CLPB,XPO7,PDZD7,TULP4,FCGBP,CHAC1,NLGN2,SOD3,ABCA3,TNXB,NCAN,ADGRG6,RRP12,SCARF1,HNRNPM,HSD3B2,DPY19L3,THSD4,ASPG,L1CAM,TSPEAR,GNAO1,EMX2,ABCA5,ZMYM1,FASN,TMEM187,CSMD3,B4GALT1,PKD1L2,MAPK4,C1QL1,CD209,SYT12,FUT6,PGK1,DDX20,RRP36,MEGF11,EMILIN2,MEGF10,CSRNP3,SUSD2,CACHD1,ANGPT2,CEBPD,TENM3,CUBN,ATL2,ANK1,TNFSF14,BCHE,LRRC74A,WRN,MB21D2,PTPRK,FAT4,MMRN2,THAP2,KIFC1,MMRN1,SLC16A4,POU3F3 93 Cancer, Organismal Injury and Abnormalities genitourinary carcinoma Genitourinary carcinoma 1.41E-04 KRT8,CELSR1,LGMN,CHRNA10,TRIM3,GLB1,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,HSPA12B,ITIH6,PTK7,NLGN2,PTPRG,TNXB,ADGRG6,HSD3B2,RASEF,CR1,THSD4,ASPG,L1CAM,TSPEAR,SCARF2,CALM1 (includes others),SNAP25,GNAO1,FASN,HARBI1,FAM234B,TMEM187,CGAS,PKD1L2,SERINC2,MAPK4,CALCRL,CD209,DDX20,EMILIN2,MEGF10,FRRS1,TSG101,LRP4,MEGF6,TENM3,PLIN2,FAM111A,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,MMRN1,BIRC2,CLEC10A,LRP5,ADAMTS16,TMPRSS6,PLG,AKNA,TNR,RRM2,CHRNB3,FLNC,HCRTR2,VWDE,RABL2B,PGBD4,DDO,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,GSTM3,TULP4,ANGPTL3,FCGBP,ABCA3,NCAN,RRP12,HNRNPM,C1QTNF4,ANKRD50,NUBP1,DPY19L3,ABCA5,ZMYM1,LITAF,CSMD3,C1QL1,PGK1,ITGB3,MEGF11,CASP2,TRIM36,COLEC11,CACHD1,CEBPD,ANGPT2,TSNARE1,CUBN,ANK1,PPP1CA,ETNK1,KMT5A,WRN,FAT4,IFI44,THAP2,KIFC1,TMEM161B,SLC16A4,POU3F3 122 Cancer, Organismal Injury and Abnormalities cancer Cancer of cells 1.42E-04 -1.941 -1.883 CELSR1,KRT8,LRP5,LGMN,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,BIRC3,BBX,AKNA,TNR,RRM2,TRPM2,CHRNB3,SYCE2,FGL1,FLNC,SLC5A7,LRP6,HCRTR2,VWDE,PTGIR,MATR3,ANOS1,SVEP1,ITIH6,PDZD7,TULP4,FCGBP,PTK7,NLGN2,SOD3,AGA,PTPRG,TNXB,NCAN,RRP12,ANKRD50,NUBP1,HNRNPM,THSD4,CR1,TTC24,L1CAM,SCARF2,TSPEAR,SNAP25,GNAO1,FASN,HARBI1,CSMD3,PKD1L2,SERINC2,CALCRL,FUT6,PGK1,ITGB3,MEGF11,EMILIN2,CASP2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,CACHD1,ANGPT2,CEBPD,MEGF6,TENM3,TSNARE1,CUBN,ANK1,TNFSF14,PPP1CA,BCHE,KMT5A,WRN,POLI,TRIM56,MB21D2,PRKCSH,PTPRK,SLC16A7,FAT4,MMRN2,IFI44,KIFC1,TMEM161B 91 Cancer, Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities bile duct carcinoma Bile duct carcinoma 1.46E-04 HDHD5,KRT8,CELSR1,LRP4,TENM3,TSNARE1,L3HYPDH,SVEP1,ALDH7A1,TMPRSS6,TULP4,CSMD3,AKNA,RRM2,AGA,FAT4,DDX20,PGK1,LRP6,TMEM161B,HSPA12B,SCARF2 22 Cancer, Organismal Injury and Abnormalities, Renal and Urological Disease urinary tract cancer Urinary tract cancer 1.49E-04 KRT8,CELSR1,CHRNA10,ADAMTS16,TMPRSS6,GLB1,BIRC3,AKNA,TNR,RRM2,TRPM2,TKFC,CHRNB3,FGL1,FLNC,SNX33,MGAT4C,ALDH7A1,XPO7,GSTM3,PTK7,TNXB,NCAN,RRP12,NUBP1,HNRNPM,CR1,L1CAM,SCARF2,TSPEAR,HARBI1,CGAS,CSMD3,PKD1L2,SERINC2,C1QL1,CALCRL,CD209,PGK1,ITGB3,NANOS1,EMILIN2,CASP2,CEBPD,MEGF6,CUBN,ANK1,PPP1CA,KMT5A,PLIN2,WRN,POLI,MB21D2,FAT4,THAP2,TMEM161B 56 Cancer, Organismal Injury and Abnormalities liquid tumor Liquid tumor 1.49E-04 KRT8,CELSR1,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,BIRC3,BBX,AKNA,TNR,RRM2,CHRNB3,FGL1,FLNC,RABL2B,ANOS1,SVEP1,ALDH7A1,XPO7,TULP4,FCGBP,PTK7,PTPRG,TNXB,NCAN,RASEF,CR1,TSPEAR,ZMYM1,CSMD3,PKD1L2,SERINC2,CALCRL,ITGB3,EMILIN2,MEGF10,SUSD2,LRP4,CACHD1,CEBPD,TENM3,TSNARE1,CUBN,ATL2,ANK1,PPP1CA,ETNK1,BCHE,KMT5A,PTPRK,SLC16A7,FAT4 52 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities colorectal neoplasia Colorectal tumor 1.49E-04 CELSR1,KRT8,LRP5,L3HYPDH,SULT1A2,ADAMTS16,TMPRSS6,TRIM3,GLB1,PLG,AOC1,TNR,RRM2,TRPM2,CHRNB3,FGL1,LRP6,HCRTR2,VWDE,SNX33,HSPA12B,C1QTNF3,MATR3,REG1A,ARL6IP4,RNF207,ANOS1,TRAF3IP2,SVEP1,MGAT4C,CLPB,XPO7,PDZD7,TULP4,FCGBP,CHAC1,NLGN2,SOD3,ABCA3,TNXB,NCAN,ADGRG6,RRP12,SCARF1,HNRNPM,HSD3B2,DPY19L3,THSD4,ASPG,L1CAM,TSPEAR,GNAO1,EMX2,ABCA5,ZMYM1,FASN,TMEM187,CSMD3,B4GALT1,PKD1L2,MAPK4,C1QL1,CD209,SYT12,FUT6,PGK1,DDX20,RRP36,MEGF11,EMILIN2,MEGF10,CSRNP3,SUSD2,CACHD1,ANGPT2,CEBPD,TENM3,CUBN,ATL2,ANK1,TNFSF14,BCHE,LRRC74A,WRN,BBLN,MB21D2,PTPRK,FAT4,MMRN2,THAP2,KIFC1,MMRN1,SLC16A4,POU3F3 94 Cancer, Hematological Disease, Organismal Injury and Abnormalities mature lymphocytic neoplasm Mature lymphocytic neoplasm 1.52E-04 KRT8,CELSR1,LGMN,FASN,ADAMTS16,CSMD3,TRIM3,BIRC3,BBX,PKD1L2,AKNA,RRM2,CALCRL,PGK1,ITGB3,SLC5A7,LRP6,VWDE,CASP2,MEGF10,FRRS1,LRP4,ANOS1,CEBPD,MEGF6,ANGPT2,CUBN,SVEP1,PPP1CA,BCHE,PTK7,PTPRK,FAT4,IFI44,TNXB,NCAN,ANKRD50,NUBP1,HNRNPM,CR1,L1CAM,TSPEAR 42 Cancer, Organismal Injury and Abnormalities, Renal and Urological Disease renal cell cancer Renal cell carcinoma 1.57E-04 KRT8,CHRNA10,TMPRSS6,CSMD3,GLB1,PKD1L2,SERINC2,AKNA,TNR,RRM2,TRPM2,TKFC,CALCRL,ITGB3,FLNC,CASP2,CUBN,ANK1,ALDH7A1,GSTM3,PLIN2,WRN,PTK7,POLI,FAT4,THAP2,NCAN,NUBP1,HNRNPM,TMEM161B,CR1,L1CAM,TSPEAR 33 Cancer, Hematological Disease, Organismal Injury and Abnormalities myelodysplastic syndrome or leukemia Myelodysplastic syndrome or leukemia 1.66E-04 KRT8,CELSR1,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,BIRC3,BBX,AKNA,TNR,RRM2,CHRNB3,FGL1,FLNC,RABL2B,ANOS1,SVEP1,ALDH7A1,XPO7,TULP4,FCGBP,PTK7,PTPRG,TNXB,NCAN,RASEF,CR1,TSPEAR,ZMYM1,CSMD3,PKD1L2,SERINC2,CALCRL,ITGB3,EMILIN2,MEGF10,SUSD2,LRP4,CACHD1,TENM3,TSNARE1,CUBN,ATL2,ANK1,PPP1CA,ETNK1,BCHE,KMT5A,PTPRK,SLC16A7,FAT4 51 Organismal Injury and Abnormalities, Renal and Urological Disease renal lesion Renal lesion 1.73E-04 1.067 0.997 KRT8,LGMN,CHRNA10,TMPRSS6,CSMD3,GLB1,PKD1L2,SERINC2,AKNA,TNR,RRM2,TRPM2,TKFC,CALCRL,ITGB3,FLNC,NANOS1,CASP2,ANGPT2,CUBN,ANK1,ALDH7A1,GSTM3,PLIN2,WRN,PTK7,POLI,AGA,FAT4,THAP2,NCAN,NUBP1,HNRNPM,TMEM161B,CR1,L1CAM,TSPEAR 37 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease endometrioid endometrial adenocarcinoma Endometrioid endometrial adenocarcinoma 1.76E-04 BIRC2,CELSR1,KRT8,LRP5,LGMN,ADAMTS16,TMPRSS6,TRIM3,SLC16A14,TNR,TRPM2,CHRNB3,TKFC,PNLIP,FLNC,HCRTR2,VWDE,SNX33,RABL2B,PGBD4,RNF207,ANOS1,TRAF3IP2,SVEP1,ITIH6,XPO7,TULP4,ANGPTL3,FCGBP,NLGN2,TNXB,C1QTNF4,ANKRD50,NUBP1,RASEF,CR1,L1CAM,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,ABCA5,ZMYM1,HARBI1,CGAS,CSMD3,MAPK4,CD209,CALCRL,PGK1,DDX20,ITGB3,MEGF10,COLEC11,FRRS1,LRP4,CACHD1,ANGPT2,MEGF6,TENM3,TSNARE1,CUBN,LRRC74A,POLI,TRIM56,PTPRK,SLC16A7,FAT4,IFI44,MMRN1,SLC16A4,POU3F3 72 Embryonic Development, Organismal Development, Tissue Development, Tissue Morphology expansion Expansion of neuroectoderm 1.80E-04 LRP5,LRP6 2 Nutritional Disease, Organismal Injury and Abnormalities weight regain Weight regain 1.80E-04 PNLIP,FASN 2 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities hairy cell leukemia Hairy cell leukemia 1.84E-04 AKNA,LRP4,RRM2,PTPRK,FAT4,ADAMTS16,MEGF10,TRIM3,PTK7,PKD1L2,TSPEAR 11 Organismal Injury and Abnormalities, Reproductive System Disease abnormality of endometrium Abnormality of endometrium 1.85E-04 BIRC2,CELSR1,KRT8,LRP5,LGMN,ADAMTS16,TMPRSS6,TRIM3,PLG,SLC16A14,TNR,TRPM2,CHRNB3,TKFC,PNLIP,FLNC,HCRTR2,VWDE,SNX33,RABL2B,PGBD4,RNF207,ANOS1,TRAF3IP2,SVEP1,ITIH6,GSTM3,XPO7,TULP4,ANGPTL3,FCGBP,NLGN2,ABCA3,TNXB,C1QTNF4,ANKRD50,NUBP1,RASEF,CR1,L1CAM,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,ABCA5,MFSD1,ZMYM1,HARBI1,CGAS,CSMD3,SERINC2,MAPK4,CD209,CALCRL,PGK1,DDX20,ITGB3,MEGF10,COLEC11,FRRS1,LRP4,CACHD1,ANGPT2,MEGF6,TENM3,TSNARE1,CUBN,ANK1,LRRC74A,POLI,PIF1,TRIM56,PTPRK,SLC16A7,FAT4,IFI44,KIFC1,MMRN1,SLC16A4,POU3F3 80 Endocrine System Disorders, Gastrointestinal Disease, Organismal Injury and Abnormalities pancreatic lesion Pancreatic lesion 1.90E-04 BIRC2,KRT8,CELSR1,CHRNA10,TMPRSS6,TRIM3,PLG,TNR,RRM2,TRPM2,TKFC,FLNC,SLC5A7,HCRTR2,VWDE,RNF207,ALDH7A1,PDZD7,TPPP3,PTK7,NLGN2,PTPRG,ABCA3,TNXB,NCAN,RRP12,L1CAM,SCARF2,TSPEAR,EMX2,FASN,CSMD3,MAPK4,DDX20,PGK1,ITGB3,TRIM36,COLEC11,FRRS1,SUSD2,ANGPT2,TENM3,CUBN,ANK1,PPP1CA,ETNK1,BCHE,WRN,POLI,TRIM56,PRKCSH,FAT4,MMRN2,TMEM161B,SLC16A4 55 Cancer, Endocrine System Disorders, Gastrointestinal Disease, Organismal Injury and Abnormalities pancreatic cancer Pancreatic cancer 1.95E-04 BIRC2,CELSR1,TMPRSS6,TRIM3,PLG,TNR,RRM2,TRPM2,TKFC,FLNC,SLC5A7,HCRTR2,VWDE,RNF207,ALDH7A1,PDZD7,TPPP3,PTK7,NLGN2,PTPRG,ABCA3,TNXB,NCAN,RRP12,L1CAM,TSPEAR,EMX2,FASN,CSMD3,DDX20,PGK1,ITGB3,TRIM36,COLEC11,FRRS1,SUSD2,ANGPT2,TENM3,CUBN,ANK1,PPP1CA,BCHE,WRN,POLI,TRIM56,PRKCSH,FAT4,TMEM161B,SLC16A4 49 Cancer, Endocrine System Disorders, Gastrointestinal Disease, Organismal Injury and Abnormalities carcinoma Pancreatic carcinoma 1.98E-04 BIRC2,CELSR1,EMX2,FASN,TMPRSS6,CSMD3,TRIM3,TNR,RRM2,TRPM2,TKFC,DDX20,PGK1,ITGB3,FLNC,SLC5A7,HCRTR2,VWDE,TRIM36,COLEC11,FRRS1,SUSD2,RNF207,ANGPT2,TENM3,CUBN,ANK1,ALDH7A1,PDZD7,BCHE,TPPP3,WRN,PTK7,POLI,NLGN2,TRIM56,PRKCSH,FAT4,PTPRG,ABCA3,TNXB,NCAN,RRP12,TMEM161B,SLC16A4,L1CAM,TSPEAR 47 Cancer, Endocrine System Disorders, Gastrointestinal Disease, Organismal Injury and Abnormalities pancreatic ductal adenocarcinoma Pancreatic ductal adenocarcinoma 2.23E-04 BIRC2,CELSR1,EMX2,FASN,TMPRSS6,CSMD3,TRIM3,TNR,RRM2,TRPM2,TKFC,DDX20,PGK1,ITGB3,FLNC,SLC5A7,VWDE,TRIM36,COLEC11,FRRS1,SUSD2,RNF207,ANGPT2,TENM3,CUBN,ANK1,ALDH7A1,BCHE,TPPP3,WRN,PTK7,POLI,NLGN2,TRIM56,PRKCSH,FAT4,PTPRG,ABCA3,TNXB,NCAN,RRP12,TMEM161B,SLC16A4,TSPEAR 44 Organismal Development abnormal morphology Abnormal morphology of body cavity 2.38E-04 BIRC2,KRT8,LRP5,LGMN,EMX2,ABCA5,MFSD1,FASN,TMPRSS6,LITAF,PLG,B4GALT1,BIRC3,RRM2,TRPM2,CALCRL,PGK1,ITGB3,FLNC,LRP6,CASP2,PTGIR,COLEC11,FRRS1,TSG101,LRP4,ANGPT2,TRAF3IP2,TNFSF14,PPP1CA,AGA,FAT4,ABCA3,SCARF1,POU3F3 35 Inflammatory Response, Organismal Injury and Abnormalities inflammation Inflammation of body cavity 2.63E-04 -0.394 -0.573 BIRC2,KRT8,LRP5,CHRNA10,FASN,CGAS,TRIM3,PLG,B4GALT1,BIRC3,SERINC2,TRPM2,CHRNB3,CALCRL,PNLIP,ITGB3,LRP6,CASP2,REG1A,FRRS1,TSG101,ANGPT2,TRAF3IP2,TNFSF14,WRN,IFI44,SCARF1,CR1 28 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities B cell cancer B cell cancer 2.65E-04 KRT8,CELSR1,LGMN,CHRNA10,FASN,TMPRSS6,BIRC3,BBX,RRM2,SYCE2,CALCRL,PGK1,ITGB3,SLC5A7,LRP6,VWDE,CASP2,FRRS1,LRP4,CACHD1,ANOS1,CEBPD,TENM3,TSNARE1,CUBN,SVEP1,ANK1,PPP1CA,BCHE,FCGBP,PTPRK,SLC16A7,FAT4,PTPRG,TNXB,NCAN,ANKRD50,NUBP1,HNRNPM,CR1,L1CAM 41 Cancer, Organismal Injury and Abnormalities cancer of head Cancer of head 2.76E-04 KRT8,CLEC10A,CELSR1,LRP5,DGAT1,GLB1,BBX,AKNA,TNR,RRM2,TRPM2,CHRNB3,AIMP2,FLNC,CYP39A1,LRP6,SNX33,MATR3,REG1A,RNF207,MKX,SVEP1,PDZD7,TULP4,NLGN2,SOD3,TNXB,NCAN,HNRNPM,DPY19L3,THSD4,TTC24,SNAP25,MFSD1,FASN,HARBI1,FAM234B,CSMD3,SERINC2,TRIM2,PGK1,ITGB3,MEGF11,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,CACHD1,ANGPT2,CUBN,ATL2,ANK1,TNFSF14,PPP1CA,FAM111A,WRN,POLI,PRKCSH,TMEM161B,SLC16A4 62 Cancer, Organismal Injury and Abnormalities mixed neoplasia Mixed neoplasia 2.77E-04 KRT8,MFSD1,CSMD3,GLB1,PLG,BIRC3,SERINC2,AKNA,TNR,RRM2,CHRNB3,PGK1,NANOS1,VWDE,TRIM36,HSPA12B,RABL2B,LRP4,TENM3,CUBN,SVEP1,ANK1,TULP4,PIF1,FAT4,PTPRG,ABCA3,TNXB,NCAN,HNRNPM,HSD3B2,POU3F3,SCARF2 33 Dermatological Diseases and Conditions, Organismal Injury and Abnormalities disorder of hair Disorder of hair 2.81E-04 -1.044 -1.212 CELSR1,AGA,SNAP25,ABCA5,DGAT1,TMPRSS6,SCARF1,PLG,B4GALT1,TSPEAR 10 Cancer, Organismal Injury and Abnormalities, Renal and Urological Disease renal cancer Renal cancer 3.29E-04 KRT8,CHRNA10,TMPRSS6,CSMD3,GLB1,PKD1L2,SERINC2,AKNA,TNR,RRM2,TRPM2,TKFC,CALCRL,ITGB3,FLNC,NANOS1,CASP2,CUBN,ANK1,ALDH7A1,GSTM3,PLIN2,WRN,PTK7,POLI,FAT4,THAP2,NCAN,NUBP1,HNRNPM,TMEM161B,CR1,L1CAM,TSPEAR 34 Organismal Injury and Abnormalities shoulder pain Shoulder pain 3.45E-04 CHRNB3,SNAP25,CHRNA10,PLG 4 Cellular Movement dissemination Dissemination of tumor cells 3.47E-04 ANGPT2,EMILIN2,L1CAM 3 Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry quantity Quantity of cerebroside 3.47E-04 FASN,GLB1,B4GALT1 3 Ophthalmic Disease, Organismal Injury and Abnormalities esotropia Esotropia 3.57E-04 SNAP25,BCHE 2 Organismal Injury and Abnormalities fibrosis Fibrosis of exocrine gland 3.57E-04 KRT8,TRAF3IP2 2 Carbohydrate Metabolism, Lipid Metabolism, Small Molecule Biochemistry incorporation Incorporation of phosphatidylethanolamine 3.57E-04 ABCA3,ETNK1 2 Cancer, Organismal Injury and Abnormalities extraadrenal retroperitoneal tumor Extraadrenal retroperitoneal tumor 3.71E-04 BIRC2,CELSR1,KRT8,CHRNA10,TMPRSS6,TRIM3,GLB1,PLG,AKNA,TNR,RRM2,TRPM2,TKFC,FLNC,SLC5A7,HCRTR2,VWDE,RNF207,ALDH7A1,GSTM3,PDZD7,TPPP3,PTK7,NLGN2,PTPRG,ABCA3,TNXB,NCAN,RRP12,NUBP1,HNRNPM,CR1,L1CAM,SCARF2,TSPEAR,EMX2,FASN,CSMD3,PKD1L2,SERINC2,MAPK4,CALCRL,PGK1,DDX20,ITGB3,NANOS1,CASP2,TRIM36,COLEC11,FRRS1,SUSD2,ANGPT2,TENM3,CUBN,ANK1,PPP1CA,BCHE,PLIN2,WRN,POLI,TRIM56,PRKCSH,FAT4,MMRN2,THAP2,TMEM161B,SLC16A4 67 Inflammatory Response, Organismal Injury and Abnormalities inflammation Inflammation of organ 4.00E-04 -0.197 -0.335 BIRC2,KRT8,LRP5,LGMN,CHRNA10,FASN,DGAT1,CGAS,TRIM3,PLG,B4GALT1,BIRC3,SERINC2,RRM2,TRPM2,CHRNB3,CALCRL,PNLIP,ITGB3,LRP6,CASP2,PTGIR,REG1A,FRRS1,TSG101,ANGPT2,TRAF3IP2,TENM3,TNFSF14,WRN,FCGBP,SOD3,IFI44,SCARF1,CR1 35 Cancer, Cardiovascular System Development and Function, Organismal Injury and Abnormalities, Tumor Morphology vascularization Vascularization of tumor 4.04E-04 RRM2,ANGPT2,MMRN2,ITGB3,PLG 5 Cell Death and Survival anoikis Anoikis of intestinal cell lines 4.09E-04 BIRC2,CASP2,BIRC3 3 Organismal Injury and Abnormalities, Organismal Survival organismal death Organismal death 4.37E-04 1.512 0.818 BIRC2,CELSR1,KRT8,LRP5,TMPRSS6,GLB1,PLG,BIRC3,AKNA,FLNC,SLC5A7,LRP6,PTGIR,TRAF3IP2,ALDH7A1,XPO7,ANGPTL3,NLGN2,SOD3,AGA,ABCA3,TNXB,ADGRG6,NUBP1,L1CAM,RAB11A,SNAP25,GNAO1,EMX2,ABCA5,FASN,CGAS,B4GALT1,CALCRL,PGK1,ITGB3,CASP2,CSRNP3,TSG101,LRP4,ANGPT2,CEBPD,TENM3,BCHE,KMT5A,PLIN2,WRN,GGNBP2,PRKCSH,FAT4,KIFC1,POU3F3 52 Cellular Assembly and Organization organization Organization of plasma membrane 4.68E-04 NLGN2,TNR,LRP4,Prrt1,FAT4,CR1,L1CAM 7 Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development development Development of neural cells 4.84E-04 1.071 1.292 CELSR1,LRP4,RAB11A,GNAO1,FASN,P2rx7,CSMD3,TRIM3,PLG,NLGN2,TNR,PRKCSH,PTPRK,MMRN2,NCAN,ITGB3,ADGRG6,SLC5A7,LRP6,KIFC1,SCARF1,NANOS1,L1CAM 23 Cellular Assembly and Organization quantity Quantity of vesicles 5.05E-04 -1.342 -1.268 TNR,LRP4,ABCA3,LITAF,SNX33,SLC16A4 6 Organ Morphology, Organismal Development, Organismal Injury and Abnormalities, Renal and Urological Disease, Renal and Urological System Development and Function abnormal morphology Abnormal morphology of kidney 5.30E-04 LRP4,AGA,TRAF3IP2,LGMN,FAT4,EMX2,PLG,POU3F3,COLEC11,B4GALT1 10 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities leukemia Leukemia 5.43E-04 KRT8,CELSR1,CHRNA10,ZMYM1,ADAMTS16,TMPRSS6,TRIM3,BIRC3,BBX,PKD1L2,AKNA,TNR,RRM2,CHRNB3,CALCRL,FGL1,ITGB3,FLNC,EMILIN2,MEGF10,RABL2B,SUSD2,LRP4,CACHD1,ANOS1,TENM3,TSNARE1,CUBN,SVEP1,ATL2,ANK1,ALDH7A1,XPO7,PPP1CA,ETNK1,BCHE,KMT5A,TULP4,FCGBP,PTK7,PTPRK,SLC16A7,FAT4,PTPRG,TNXB,NCAN,CR1,TSPEAR 48 Cancer, Endocrine System Disorders, Gastrointestinal Disease, Organismal Injury and Abnormalities pancreatic tumor Pancreatic tumor 5.47E-04 BIRC2,CELSR1,CHRNA10,TMPRSS6,TRIM3,PLG,TNR,RRM2,TRPM2,TKFC,FLNC,SLC5A7,HCRTR2,VWDE,RNF207,ALDH7A1,PDZD7,TPPP3,PTK7,NLGN2,PTPRG,ABCA3,TNXB,NCAN,RRP12,L1CAM,SCARF2,TSPEAR,EMX2,FASN,CSMD3,MAPK4,DDX20,PGK1,ITGB3,TRIM36,COLEC11,FRRS1,SUSD2,ANGPT2,TENM3,CUBN,ANK1,PPP1CA,BCHE,WRN,POLI,TRIM56,PRKCSH,FAT4,MMRN2,TMEM161B,SLC16A4 53 Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development development Development of neurons 5.73E-04 0.566 0.766 CELSR1,LRP4,RAB11A,GNAO1,FASN,P2rx7,CSMD3,TRIM3,PLG,NLGN2,TNR,PRKCSH,PTPRK,NCAN,ITGB3,ADGRG6,SLC5A7,LRP6,KIFC1,SCARF1,NANOS1,L1CAM 22 Antimicrobial Response, Cell-To-Cell Signaling and Interaction, Inflammatory Response, Renal and Urological System Development and Function antiviral response Antiviral response of kidney cell lines 5.93E-04 BIRC2,BIRC3 2 Cell-To-Cell Signaling and Interaction binding Binding of retinal cells 5.93E-04 CD209,L1CAM 2 Cell Death and Survival, Embryonic Development, Organismal Injury and Abnormalities apoptosis Delay in apoptosis of embryonic cell lines 5.93E-04 BIRC2,BIRC3 2 Connective Tissue Development and Function, Connective Tissue Disorders, Nervous System Development and Function, Organ Morphology, Organismal Development, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders, Skeletal and Muscular System Development and Function, Tissue Development elongation Elongation of axis 5.93E-04 LRP6,PTK7 2 Carbohydrate Metabolism glycosylation Glycosylation of carbohydrate 5.93E-04 RAB11A,B4GALT1 2 Tissue Morphology quantity Quantity of segmented filamentous bacterium 5.93E-04 LRP5,LRP6 2 Cell-To-Cell Signaling and Interaction, Tissue Development binding Binding of extracellular matrix 6.18E-04 TNXB,ITGB3,ANGPTL3,PLG,B4GALT1,L1CAM 6 Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development myelination Myelination of neurons 6.65E-04 -1.961 -1.827 FASN,ADGRG6,P2rx7,L1CAM 4 Inflammatory Response inflammatory response Inflammatory response 6.73E-04 -1.631 -1.483 BIRC2,CEBPD,ANGPT2,TRAF3IP2,LGMN,GNAO1,TNFSF14,FASN,LITAF,P2rx7,PLIN2,PLG,B4GALT1,BIRC3,AKNA,TRPM2,SOD3,CALCRL,ITGB3,Fcna,CR1,C1QTNF3 22 Cancer, Organismal Injury and Abnormalities facial squamous cell carcinoma Facial squamous cell carcinoma 7.17E-04 NLGN2,FRRS1,RRM2,SERINC2 4 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease uterine carcinoma Uterine carcinoma 7.22E-04 BIRC2,CELSR1,KRT8,LRP5,LGMN,ADAMTS16,TMPRSS6,TRIM3,SLC16A14,TRPM2,TNR,RRM2,CHRNB3,TKFC,PNLIP,FLNC,HCRTR2,VWDE,SNX33,RABL2B,PGBD4,RNF207,ANOS1,TRAF3IP2,SVEP1,ITIH6,XPO7,TULP4,ANGPTL3,FCGBP,NLGN2,TNXB,C1QTNF4,ANKRD50,NUBP1,RASEF,CR1,L1CAM,TSPEAR,CALM1 (includes others),SNAP25,GNAO1,ABCA5,ZMYM1,HARBI1,CGAS,CSMD3,MAPK4,CD209,CALCRL,PGK1,DDX20,ITGB3,MEGF10,COLEC11,FRRS1,LRP4,CACHD1,ANGPT2,MEGF6,TENM3,TSNARE1,CUBN,LRRC74A,POLI,TRIM56,MB21D2,PTPRK,SLC16A7,FAT4,IFI44,KIFC1,MMRN1,SLC16A4,POU3F3 75 Cellular Assembly and Organization, Cellular Function and Maintenance assembly Assembly of multivesicular bodies 7.31E-04 TSG101,RAB11A,VPS25 3 Nervous System Development and Function, Organismal Development, Skeletal and Muscular System Development and Function coordination Coordination of limb 7.31E-04 AGA,ADGRG6,L1CAM 3 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities oral squamous cell carcinoma Oral squamous cell carcinoma 7.32E-04 SNAP25,FASN,HARBI1,CSMD3,SERINC2,TNR,RRM2,TRPM2,CHRNB3,PGK1,LRP6,EMILIN2,MEGF10,MATR3,FRRS1,LRP4,CUBN,PPP1CA,WRN,POLI,NLGN2,SOD3,PRKCSH,HNRNPM,TMEM161B,THSD4 26 Cancer, Organismal Injury and Abnormalities multiple cancers Multiple cancers 7.79E-04 BIRC2,CLEC10A,KRT8,LRP5,TRIM3,GLB1,PLG,BIRC3,AOC1,AKNA,TNR,RRM2,CHRNB3,FLNC,LRP6,ADRM1,HSPA12B,SVEP1,ALDH7A1,GSTM3,XPO7,TULP4,FCGBP,PTK7,NLGN2,H2BC21,PTPRG,ABCA3,TNXB,NCAN,ADGRG6,RRP12,ANKRD50,NUBP1,HNRNPM,HSD3B2,THSD4,RASEF,CR1,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),ZMYM1,FASN,FAM234B,CSMD3,PKD1L2,MAPK4,PGK1,DDX20,ITGB3,EMILIN2,CASP2,TRIM36,TSG101,LRP4,CACHD1,ANGPT2,CEBPD,TENM3,CUBN,ANK1,ETNK1,ACAA1,KMT5A,PLIN2,FAM111A,WRN,POLI,MB21D2,PTPRK,FAT4,KIFC1 74 Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities B-cell chronic lymphoproliferative disorder B-cell chronic lymphoproliferative disorder 7.95E-04 CELSR1,LRP4,SVEP1,PPP1CA,ADAMTS16,TRIM3,PKD1L2,BIRC3,PTK7,AKNA,RRM2,PTPRK,FAT4,MEGF10,TSPEAR 15 Cancer, Organismal Injury and Abnormalities blue round small cell tumor Blue round small cell tumor 8.04E-04 CELSR1,LRP5,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,TNR,RRM2,TRPM2,TKFC,SYCE2,FLNC,SLC5A7,ADRM1,SNX33,VWDE,ANOS1,SVEP1,MGAT4C,PDZD7,CLPB,FCGBP,NLGN2,TNXB,HNRNPM,ASPG,CR1,TSPEAR,FASN,TMEM187,CGAS,CSMD3,PKD1L2,SERINC2,TRIM2,PGK1,RRP36,EMILIN2,FRRS1,TSG101,CEBPD,ANGPT2,TENM3,CUBN,BCHE,KMT5A,MB21D2,PRKCSH,FAT4,IFI44,POU3F3 52 Nervous System Development and Function, Organismal Development, Tissue Development morphogenesis Morphogenesis of nervous tissue 8.07E-04 1.366 1.540 CELSR1,LRP4,RAB11A,GNAO1,FASN,CSMD3,TRIM3,PLG,NLGN2,TNR,PRKCSH,PTPRK,ITGB3,ADGRG6,KIFC1,SCARF1,NANOS1,L1CAM 18 Metabolic Disease, Neurological Disease, Organismal Injury and Abnormalities, Psychological Disorders Alzheimer disease Alzheimer disease 8.26E-04 REG1A,FRRS1,LRP4,LGMN,SNAP25,CHRNA10,XPO7,BCHE,PLG,CHRNB3,PTPRG,LRP6,CYP39A1,SLC5A7,MEGF10,CASP2,CR1 17 Dermatological Diseases and Conditions, Hair and Skin Development and Function, Organ Morphology, Organismal Injury and Abnormalities abnormal morphology Abnormal morphology of sparse hair 8.31E-04 TMPRSS6,DGAT1,B4GALT1 3 Neurological Disease, Organismal Injury and Abnormalities encephalopathy Acute encephalopathy 8.40E-04 CHRNB3,CHRNA10,ITGB3,BCHE,HCRTR2,PLG 6 Antimicrobial Response, Cell-To-Cell Signaling and Interaction, Hair and Skin Development and Function, Inflammatory Response antiviral response Antiviral response of epithelial cell lines 8.84E-04 BIRC2,BIRC3 2 Cell Death and Survival, Organismal Injury and Abnormalities apoptosis Delay in apoptosis of fibroblast cell lines 8.84E-04 BIRC2,BIRC3 2 Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism hydrolysis Hydrolysis of retinyl ester 8.84E-04 PNLIP,ACAA1 2 Cancer, Developmental Disorder, Gastrointestinal Disease, Hepatic System Disease, Hereditary Disorder, Organismal Injury and Abnormalities polycystic liver disease 1 Polycystic liver disease 1 8.84E-04 LRP5,PRKCSH 2 Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry quantity Quantity of galactosylceramide 8.84E-04 GLB1,B4GALT1 2 Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities, Respiratory Disease small cell lung cancer Small cell lung carcinoma 8.90E-04 CELSR1,LRP5,FASN,ADAMTS16,TMPRSS6,CGAS,CSMD3,TRIM3,PLG,PKD1L2,SERINC2,TRPM2,TNR,RRM2,TKFC,TRIM2,PGK1,FLNC,SLC5A7,ADRM1,VWDE,EMILIN2,FRRS1,TSG101,ANOS1,ANGPT2,TENM3,CUBN,SVEP1,MGAT4C,PDZD7,CLPB,BCHE,NLGN2,PRKCSH,FAT4,IFI44,TNXB,ASPG,CR1,POU3F3,TSPEAR 42 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities chronic form of lymphocytic leukemia Chronic form of lymphocytic leukemia 8.96E-04 CELSR1,LRP4,SVEP1,PPP1CA,ADAMTS16,TRIM3,PKD1L2,BIRC3,PTK7,AKNA,RRM2,PTPRK,FAT4,MEGF10,TSPEAR 15 Cancer, Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities hepatocellular carcinoma Hepatocellular carcinoma 9.12E-04 BIRC2,KRT8,GNAO1,FASN,TMPRSS6,CSMD3,GLB1,PLG,SERINC2,TNR,RRM2,TKFC,PGK1,FGL1,LRP6,CYP39A1,VWDE,CASP2,C1QTNF3,ANOS1,MKX,CUBN,SVEP1,XPO7,ACAA1,FAT4,PTPRG,KIFC1,RASEF,CR1,SCARF2,TSPEAR 32 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease breast or ovarian cancer Breast or ovarian cancer 9.23E-04 BIRC2,CLEC10A,KRT8,LRP5,TRIM3,GLB1,PLG,AOC1,AKNA,TNR,RRM2,CHRNB3,FLNC,LRP6,ADRM1,HSPA12B,SVEP1,ALDH7A1,GSTM3,XPO7,TULP4,FCGBP,PTK7,NLGN2,H2BC21,PTPRG,ABCA3,TNXB,NCAN,ADGRG6,RRP12,ANKRD50,NUBP1,HNRNPM,HSD3B2,THSD4,RASEF,L1CAM,SCARF2,TSPEAR,CALM1 (includes others),ZMYM1,FASN,FAM234B,CSMD3,PKD1L2,MAPK4,PGK1,DDX20,ITGB3,EMILIN2,CASP2,TRIM36,TSG101,LRP4,CACHD1,ANGPT2,CEBPD,TENM3,CUBN,ANK1,ETNK1,ACAA1,KMT5A,PLIN2,FAM111A,WRN,POLI,MB21D2,PTPRK,FAT4,KIFC1 72 Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities extrapancreatic neuroendocrine tumor Extrapancreatic neuroendocrine tumor 9.34E-04 BIRC2,CELSR1,LRP5,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,TNR,RRM2,TRPM2,TKFC,FLNC,SLC5A7,ADRM1,SNX33,VWDE,ANOS1,SVEP1,MGAT4C,PDZD7,CLPB,NLGN2,TNXB,HNRNPM,ASPG,CR1,SCARF2,TSPEAR,FASN,CGAS,CSMD3,PKD1L2,SERINC2,TRIM2,PGK1,EMILIN2,COLEC11,FRRS1,TSG101,CEBPD,ANGPT2,TENM3,CUBN,BCHE,MB21D2,PRKCSH,FAT4,MMRN2,DUT,IFI44,POU3F3 52 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities B-lymphoblastic leukemia/lymphoma B-lymphoblastic leukemia/lymphoma 9.45E-04 KRT8,CACHD1,CELSR1,LRP4,ANOS1,TENM3,TSNARE1,SVEP1,CHRNA10,ANK1,TMPRSS6,FCGBP,BBX,RRM2,PTPRK,SLC16A7,FAT4,PTPRG,ITGB3 19 Cancer, Organismal Injury and Abnormalities embryonal tumor Embryonal tumor 9.61E-04 FRRS1,CELSR1,LRP4,ANGPT2,GNAO1,FASN,CSMD3,FAM111A,GLB1,WRN,SERINC2,AKNA,NLGN2,TRPM2,RRM2,AGA,TNXB,PGK1,ITGB3,CASP2 20 Inflammatory Response, Organismal Injury and Abnormalities inflammation Inflammation of absolute anatomical region 1.02E-03 -0.853 -0.981 BIRC2,KRT8,LRP5,CHRNA10,FASN,DGAT1,CGAS,LITAF,TRIM3,PLG,B4GALT1,BIRC3,SERINC2,TRPM2,CHRNB3,CALCRL,PNLIP,ITGB3,LRP6,CASP2,REG1A,FRRS1,TSG101,ANGPT2,TRAF3IP2,TNFSF14,WRN,IFI44,SCARF1,CR1 30 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities lymphocytic leukemia Lymphocytic leukemia 1.03E-03 KRT8,CELSR1,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,BBX,BIRC3,PKD1L2,AKNA,RRM2,FGL1,ITGB3,MEGF10,CACHD1,LRP4,ANOS1,TENM3,TSNARE1,SVEP1,ANK1,PPP1CA,FCGBP,PTK7,PTPRK,SLC16A7,FAT4,PTPRG,TSPEAR 29 Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities neuroendocrine tumor Neuroendocrine tumor 1.04E-03 BIRC2,CELSR1,LRP5,CHRNA10,ADAMTS16,TMPRSS6,TRIM3,PLG,TNR,RRM2,TRPM2,TKFC,FLNC,SLC5A7,ADRM1,SNX33,VWDE,ANOS1,SVEP1,MGAT4C,PDZD7,CLPB,NLGN2,TNXB,HNRNPM,ASPG,CR1,SCARF2,TSPEAR,FASN,CGAS,CSMD3,PKD1L2,SERINC2,TRIM2,PGK1,ITGB3,EMILIN2,COLEC11,FRRS1,TSG101,CEBPD,ANGPT2,TENM3,CUBN,BCHE,MB21D2,PRKCSH,FAT4,MMRN2,DUT,IFI44,POU3F3 53 Lipid Metabolism, Small Molecule Biochemistry incorporation Incorporation of long chain fatty acid 1.06E-03 ABCA3,DGAT1,PLIN2 3 Cancer, Organismal Injury and Abnormalities clear-cell adenocarcinoma Clear-cell adenocarcinoma 1.07E-03 CHRNA10,TMPRSS6,CSMD3,GLB1,PKD1L2,SERINC2,TNR,RRM2,TRPM2,TKFC,ITGB3,FLNC,CASP2,ANK1,ALDH7A1,PLIN2,WRN,PTK7,POLI,FAT4,NCAN,NUBP1,HNRNPM,TMEM161B,CR1,L1CAM,TSPEAR 27 Organismal Injury and Abnormalities, Respiratory Disease acute respiratory disorder Acute respiratory disorder 1.16E-03 RRM2,CHRNB3,ANGPT2,H2BC21,CEBPD,CALM1 (includes others),CHRNA10,ABCA3,PLG,PTGIR,SERINC2 11 Cell-To-Cell Signaling and Interaction, Cellular Assembly and Organization, Cellular Function and Maintenance, Tissue Development organization Organization of synapse 1.17E-03 NLGN2,TNR,LRP4,Prrt1,L1CAM 5 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities buccal squamous cell carcinoma Buccal squamous cell carcinoma 1.18E-03 NLGN2,FRRS1,SERINC2 3 Cancer, Developmental Disorder, Gastrointestinal Disease, Hepatic System Disease, Hereditary Disorder, Organismal Injury and Abnormalities polycystic liver disease Polycystic liver disease 1.18E-03 PRKCSH,LRP5,LRP6 3 Cell-To-Cell Signaling and Interaction, Small Molecule Biochemistry synthesis Synthesis of neurotransmitter 1.23E-03 LRP5,SNAP25,SLC5A7,Cyp2d22 4 Cell-mediated Immune Response, Lymphoid Tissue Structure and Development frequency Frequency of Th1 cells 1.23E-03 LRP5,LRP6 2 Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities, Psychological Disorders, Skeletal and Muscular Disorders Huntington disease Huntington disease grade 3 Huntington disease 1.23E-03 SNAP25,CASP2 2 Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry concentration Concentration of cholesterol 1.24E-03 -0.551 -0.571 LRP5,PNLIP,FASN,FGL1,CACFD1,ITGB3,DGAT1,PLIN2,ANGPTL3,CASP2,WRN 11 Cancer, Organismal Injury and Abnormalities upper aero-digestive squamous cell carcinoma Upper aero-digestive squamous cell carcinoma 1.24E-03 SNAP25,GNAO1,FASN,HARBI1,CSMD3,TRIM3,SERINC2,TNR,RRM2,TRPM2,CHRNB3,PGK1,LRP6,VWDE,EMILIN2,MEGF10,MATR3,FRRS1,LRP4,CUBN,SVEP1,PPP1CA,KMT5A,TULP4,WRN,POLI,NLGN2,SOD3,PRKCSH,FAT4,ANKRD50,HNRNPM,TMEM161B,THSD4,L1CAM 35 Nutritional Disease, Organismal Injury and Abnormalities obesity Obesity 1.26E-03 -0.127 -0.125 ANGPT2,SNAP25,CHRNA10,EMX2,SULT1A2,FASN,DGAT1,BCHE,PLIN2,WRN,SERINC2,CHRNB3,PNLIP,PGK1,ITGB3,LRP6,C1QTNF3 17 Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities small-cell carcinoma Small-cell carcinoma 1.27E-03 CELSR1,LRP5,CHRNA10,FASN,ADAMTS16,TMPRSS6,CGAS,CSMD3,TRIM3,PLG,PKD1L2,SERINC2,TNR,RRM2,TRPM2,TKFC,TRIM2,PGK1,FLNC,SLC5A7,ADRM1,SNX33,VWDE,EMILIN2,FRRS1,TSG101,ANOS1,CEBPD,ANGPT2,TENM3,CUBN,SVEP1,MGAT4C,PDZD7,CLPB,BCHE,NLGN2,MB21D2,PRKCSH,FAT4,IFI44,TNXB,HNRNPM,ASPG,CR1,POU3F3,TSPEAR 47 Cell Death and Survival, Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities cell death Cell death of hepatocytes 1.28E-03 0.478 0.452 BIRC2,KRT8,TNFSF14,FASN,CR1,PLG,BIRC3 7 Cell-To-Cell Signaling and Interaction aggregation Aggregation of cells 1.29E-03 -0.151 0.003 TRAF3IP2,CD209,ITGB3,MMRN1,SCARF1,NANOS1,EMILIN2,PLG,PTGIR,L1CAM,SCARF2 11 Cell Death and Survival, Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities necrosis Necrosis of liver 1.29E-03 0.862 0.786 BIRC2,KRT8,AGA,TNFSF14,FASN,ITGB3,CR1,PLG,BIRC3 9 Cancer, Organismal Injury and Abnormalities, Renal and Urological Disease renal clear cell cancer Renal clear cell adenocarcinoma 1.30E-03 CHRNA10,TMPRSS6,CSMD3,GLB1,PKD1L2,SERINC2,TNR,TRPM2,TKFC,ITGB3,FLNC,CASP2,ANK1,ALDH7A1,PLIN2,WRN,PTK7,POLI,FAT4,NCAN,NUBP1,HNRNPM,TMEM161B,CR1,L1CAM,TSPEAR 26 Cell Death and Survival, Organismal Injury and Abnormalities apoptosis Apoptosis of fibrosarcoma cell lines 1.31E-03 1.981 1.968 BIRC2,EMILIN2,PLG,BIRC3 4 Cell Death and Survival, Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities cell death Cell death of liver cells 1.32E-03 0.478 0.458 BIRC2,KRT8,TNFSF14,FASN,ITGB3,CR1,PLG,BIRC3 8 Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities, Reproductive System Disease epithelial ovarian tumor Ovarian carcinoma 1.33E-03 KRT8,LRP5,ZMYM1,FAM234B,CSMD3,GLB1,PKD1L2,AKNA,TNR,RRM2,CHRNB3,DDX20,TRIM36,CASP2,HSPA12B,LRP4,TSG101,ANGPT2,TENM3,CUBN,ALDH7A1,XPO7,TULP4,FCGBP,PTK7,FAT4,PTPRG,ABCA3,TNXB,NCAN,ANKRD50,HNRNPM,HSD3B2,SCARF2 34 Neurological Disease, Organismal Injury and Abnormalities neurological disorder Progressive neurological disorder 1.34E-03 CALM1 (includes others),LGMN,SNAP25,CHRNA10,FASN,PLG,TNR,RRM2,CHRNB3,DDX20,ITGB3,AIMP2,SLC5A7,LRP6,CYP39A1,HCRTR2,MEGF10,CASP2,MATR3,REG1A,FRRS1,LRP4,XPO7,BCHE,PTPRG,TNXB,CR1 27 Organismal Injury and Abnormalities, Respiratory Disease respiratory distress Respiratory distress 1.37E-03 RRM2,CHRNB3,ANGPT2,H2BC21,CEBPD,CALM1 (includes others),CHRNA10,MEGF10,PLG 9 Cell-To-Cell Signaling and Interaction, Cellular Assembly and Organization, Tissue Development adhesion Adhesion of cell-associated matrix 1.45E-03 TNXB,ITGB3,ANGPTL3,B4GALT1,L1CAM 5 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities esophageal adenocarcinoma Esophageal adenocarcinoma 1.48E-03 HDHD5,TRAF3IP2,CLPB,ADAMTS16,BCHE,CSMD3,SERINC2,FAT4,PTPRG,NCAN,CASP2,PTGIR,COLEC11 13 Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Inflammatory Response binding Binding of phagocytes 1.48E-03 -0.115 0.018 TNR,CLEC10A,ANGPT2,CD209,ITGB3,CR1,PLG,B4GALT1 8 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities low-grade lymphoma Low-grade lymphoma 1.50E-03 LGMN,CUBN,SVEP1,FASN,BCHE,BIRC3,RRM2,CALCRL,FAT4,TNXB,NCAN,ITGB3,LRP6,SLC5A7,ANKRD50,VWDE,L1CAM 17 Cancer, Neurological Disease, Organismal Injury and Abnormalities brain cancer Brain cancer 1.53E-03 KRT8,CLEC10A,CELSR1,LRP5,MFSD1,FASN,HARBI1,FAM234B,DGAT1,GLB1,BBX,SERINC2,AKNA,TRIM2,ITGB3,AIMP2,FLNC,CYP39A1,LRP6,SNX33,MEGF11,MEGF10,CSRNP3,REG1A,FRRS1,TSG101,LRP4,CACHD1,RNF207,ANGPT2,MKX,CUBN,SVEP1,ATL2,ANK1,TNFSF14,PDZD7,TULP4,FAM111A,WRN,NLGN2,PRKCSH,TNXB,NCAN,HNRNPM,DPY19L3,TTC24,SLC16A4 48 Metabolic Disease, Organismal Injury and Abnormalities, Renal and Urological Disease albuminuria Albuminuria 1.57E-03 ANGPT2,LGMN,CUBN,CR1,B4GALT1 5 Digestive System Development and Function, Hepatic System Development and Function, Organ Development response Response of liver 1.58E-03 0.277 0.203 BIRC2,KRT8,ANGPT2,CHRNA10,TNFSF14,PNLIP,FASN,CGAS,LRP6,CASP2,WRN,BIRC3 12 Developmental Disorder, Hereditary Disorder, Immunological Disease, Neurological Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders hereditary congenital myasthenic syndrome Hereditary congenital myasthenic syndrome 1.61E-03 LRP4,SNAP25,SLC5A7 3 Carbohydrate Metabolism, Small Molecule Biochemistry metabolism Metabolism of galactose 1.63E-03 GLB1,B4GALT1 2 Cell Morphology, Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Organismal Development, Tissue Development morphogenesis Morphogenesis of central nervous system cells 1.63E-03 NLGN2,L1CAM 2 Cellular Development, Cellular Growth and Proliferation, Embryonic Development, Nervous System Development and Function, Organ Development, Organismal Development, Tissue Development myelination Myelination of dorsal root ganglion cells 1.63E-03 FASN,P2rx7 2 Cell-To-Cell Signaling and Interaction, Nervous System Development and Function synaptic transmission Synaptic transmission 1.64E-03 0.000 0.092 NLGN2,TNR,LRP4,LGMN,SNAP25,CHRNA10,LRP6,SLC5A7,BCHE,HCRTR2,L1CAM 11 Cell Morphology, Cellular Assembly and Organization, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Nervous System Development and Function, Organismal Development, Tissue Development neuritogenesis Neuritogenesis 1.71E-03 1.049 1.212 CELSR1,LRP4,RAB11A,GNAO1,FASN,CSMD3,TRIM3,PLG,TNR,PRKCSH,PTPRK,ITGB3,ADGRG6,KIFC1,SCARF1,NANOS1,L1CAM 17 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities small lymphocytic lymphoma cancer Small B-cell lymphocytic lymphoma 1.79E-03 CUBN,SVEP1,BCHE,BIRC3,RRM2,CALCRL,FAT4,TNXB,NCAN,LRP6,SLC5A7,ANKRD50,VWDE 13 Cellular Function and Maintenance organization Organization of cells 1.81E-03 NLGN2,TNR,LRP4,KRT8,Prrt1,FLNC,L1CAM 7 Gastrointestinal Disease, Organismal Injury and Abnormalities, Reproductive System Disease, Skeletal and Muscular Disorders rectal prolapse Rectal prolapse 1.95E-03 KRT8,PLG,WRN 3 Cellular Function and Maintenance, Molecular Transport, Small Molecule Biochemistry homeostasis Homeostasis of iron ion 1.96E-03 FRRS1,ANK1,TMPRSS6,NUBP1 4 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities precursor B-cell acute lymphoblastic leukemia Precursor B-cell acute lymphoblastic leukemia 2.07E-03 KRT8,CACHD1,CELSR1,LRP4,ANOS1,TENM3,TSNARE1,SVEP1,CHRNA10,ANK1,TMPRSS6,FCGBP,BBX,RRM2,SLC16A7,FAT4,PTPRG,ITGB3 18 Cardiovascular Disease, Cardiovascular System Development and Function, Embryonic Development, Nervous System Development and Function, Ophthalmic Disease, Organ Development, Organ Morphology, Organismal Development, Organismal Injury and Abnormalities, Tissue Development, Tissue Morphology, Visual System Development and Function abnormal morphology Abnormal morphology of retinal blood vessel 2.09E-03 LRP5,MMRN2 2 Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry absorption Absorption of triacylglycerol 2.09E-03 PNLIP,DGAT1 2 Embryonic Development, Organismal Development, Tissue Development development Development of primitive streak 2.09E-03 LRP5,LRP6 2 Cellular Movement dissemination Dissemination of cancer cells 2.09E-03 EMILIN2,L1CAM 2 Small Molecule Biochemistry metabolism Metabolism of choline 2.09E-03 ALDH7A1,BCHE 2 Cell-To-Cell Signaling and Interaction tethering Tethering of cells 2.09E-03 CD209,FUT6 2 Cancer, Organismal Injury and Abnormalities squamous-cell carcinoma Squamous-cell carcinoma 2.17E-03 KRT8,LRP5,TMPRSS6,TRIM3,TNR,RRM2,TRPM2,CHRNB3,FLNC,SLC5A7,LRP6,HCRTR2,VWDE,PTGIR,MATR3,SVEP1,ITIH6,PDZD7,TULP4,FCGBP,PTK7,NLGN2,SOD3,AGA,TNXB,NCAN,RRP12,ANKRD50,HNRNPM,THSD4,CR1,TTC24,L1CAM,SCARF2,TSPEAR,SNAP25,GNAO1,FASN,HARBI1,CSMD3,PKD1L2,SERINC2,PGK1,MEGF11,EMILIN2,CASP2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,TENM3,CUBN,TNFSF14,PPP1CA,KMT5A,WRN,POLI,TRIM56,MB21D2,PRKCSH,FAT4,IFI44,TMEM161B 65 Connective Tissue Disorders, Developmental Disorder, Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders osteopetrosis Osteopetrosis 2.18E-03 LRP4,RRM2,LRP5,ITGB3 4 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease mammary tumor Mammary tumor 2.24E-03 BIRC2,KRT8,CLEC10A,LRP5,TRIM3,GLB1,PLG,RRM2,FLNC,LRP6,ADRM1,SVEP1,GSTM3,TULP4,FCGBP,PTK7,NLGN2,H2BC21,PTPRG,TNXB,ADGRG6,RRP12,NUBP1,HNRNPM,HSD3B2,RASEF,THSD4,L1CAM,TSPEAR,CALM1 (includes others),GNAO1,FASN,CSMD3,PKD1L2,MAPK4,PGK1,ITGB3,EMILIN2,CASP2,TSG101,LRP4,CACHD1,CEBPD,ANGPT2,TENM3,CUBN,ANK1,ETNK1,KMT5A,ACAA1,PLIN2,FAM111A,WRN,POLI,MB21D2,SLC16A7,FAT4,KIFC1 58 Lipid Metabolism, Small Molecule Biochemistry metabolism Metabolism of membrane lipid derivative 2.30E-03 -0.975 -0.830 LRP5,ABCA5,FASN,ETNK1,ANGPTL3,GLB1,B4GALT1,SERINC2,FUT6,ABCA3,FGL1,CYP39A1,ASPG 13 Organismal Injury and Abnormalities development Development of wound 2.32E-03 ITGB3,PLG,B4GALT1 3 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities chronic leukemia Chronic leukemia 2.32E-03 CELSR1,LRP4,SVEP1,PPP1CA,ETNK1,ADAMTS16,TRIM3,PKD1L2,BIRC3,PTK7,AKNA,RRM2,PTPRK,FAT4,MEGF10,TSPEAR 16 Organismal Injury and Abnormalities visceromegaly Visceromegaly 2.33E-03 KRT8,FRRS1,TSG101,ANGPT2,TRAF3IP2,LGMN,TNFSF14,ABCA5,PPP1CA,FASN,TMPRSS6,LITAF,PLG,B4GALT1,RRM2,PGK1,ITGB3,FLNC,SCARF1,PTGIR 20 Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities, Reproductive System Disease ovarian cancer Ovarian cancer 2.36E-03 KRT8,LRP5,ZMYM1,FAM234B,CSMD3,GLB1,PLG,PKD1L2,AOC1,AKNA,TNR,RRM2,CHRNB3,DDX20,TRIM36,CASP2,HSPA12B,TSG101,LRP4,ANGPT2,TENM3,CUBN,ALDH7A1,XPO7,TULP4,FCGBP,PTK7,FAT4,PTPRG,ABCA3,TNXB,NCAN,ANKRD50,HNRNPM,HSD3B2,SCARF2 36 Neurological Disease, Organismal Injury and Abnormalities, Psychological Disorders traumatic brain injury Traumatic brain injury 2.41E-03 CHRNB3,SNAP25,CHRNA10,BCHE,PLG 5 Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism metabolism Steroid metabolism 2.58E-03 LRP5,LGMN,ABCA5,FGL1,CYP39A1,HSD3B2,ACAA1,ANGPTL3,PLG 9 Nervous System Development and Function myelination Myelination 2.59E-03 Decreased -2.184 -2.172 TRPM2,FASN,AIMP2,ADGRG6,LITAF,P2rx7,CR1,PLG,GLB1,L1CAM 10 Cell Morphology, Connective Tissue Development and Function, Connective Tissue Disorders, Organismal Injury and Abnormalities, Tissue Morphology abnormal morphology Abnormal morphology of brown adipocytes 2.60E-03 CEBPD,FGL1 2 Organ Morphology, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders, Skeletal and Muscular System Development and Function abnormal morphology Abnormal morphology of intercostal muscle 2.60E-03 SNAP25,FLNC 2 Cell Morphology, Cellular Function and Maintenance autophagy Autophagy of endothelial cells 2.60E-03 BIRC2,PLG 2 Carbohydrate Metabolism, Small Molecule Biochemistry catabolism Catabolism of hexose 2.60E-03 LRP5,GLB1 2 Cell Death and Survival, Cell Morphology, Digestive System Development and Function, Gastrointestinal Disease, Organ Morphology, Organismal Development, Organismal Injury and Abnormalities loss Loss of crypt cells 2.60E-03 LRP5,LRP6 2 Cell-To-Cell Signaling and Interaction, Small Molecule Biochemistry metabolism Metabolism of acetylcholine 2.60E-03 SLC5A7,BCHE 2 Cell-To-Cell Signaling and Interaction, Cellular Assembly and Organization stabilization Stabilization of synapse 2.60E-03 TNR,NCAN 2 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease breast cancer Breast cancer 2.66E-03 BIRC2,KRT8,CLEC10A,LRP5,TRIM3,GLB1,PLG,RRM2,FLNC,LRP6,ADRM1,SVEP1,GSTM3,TULP4,FCGBP,PTK7,NLGN2,H2BC21,PTPRG,TNXB,ADGRG6,RRP12,NUBP1,HNRNPM,HSD3B2,RASEF,THSD4,L1CAM,TSPEAR,CALM1 (includes others),FASN,CSMD3,PKD1L2,MAPK4,PGK1,ITGB3,EMILIN2,CASP2,TSG101,LRP4,CACHD1,CEBPD,ANGPT2,TENM3,CUBN,ANK1,ETNK1,KMT5A,ACAA1,PLIN2,FAM111A,WRN,POLI,MB21D2,FAT4,KIFC1 56 Cancer, Organismal Injury and Abnormalities extrapulmonary squamous cell carcinoma Extrapulmonary squamous cell carcinoma 2.71E-03 KRT8,LRP5,TMPRSS6,TRIM3,TNR,RRM2,TRPM2,CHRNB3,FLNC,SLC5A7,LRP6,HCRTR2,VWDE,PTGIR,MATR3,SVEP1,ITIH6,PDZD7,TULP4,FCGBP,PTK7,NLGN2,SOD3,TNXB,RRP12,ANKRD50,HNRNPM,CR1,THSD4,TTC24,L1CAM,SCARF2,TSPEAR,SNAP25,GNAO1,FASN,HARBI1,CSMD3,PKD1L2,SERINC2,PGK1,EMILIN2,MEGF10,CSRNP3,FRRS1,TSG101,LRP4,MEGF6,CUBN,TNFSF14,PPP1CA,KMT5A,WRN,POLI,MB21D2,TRIM56,PRKCSH,FAT4,TMEM161B 59 Neurological Disease, Organismal Injury and Abnormalities progressive encephalopathy Progressive encephalopathy 2.73E-03 REG1A,FRRS1,LRP4,CALM1 (includes others),LGMN,SNAP25,CHRNA10,XPO7,FASN,BCHE,PLG,TNR,CHRNB3,PTPRG,DDX20,AIMP2,SLC5A7,LRP6,CYP39A1,MEGF10,CASP2,CR1,MATR3 23 Molecular Transport transport Transport of molecule 2.76E-03 -0.589 -0.364 KRT8,RAB11A,CALM1 (includes others),SNAP25,GNAO1,ABCA5,DGAT1,TMPRSS6,B4GALT1,AOC1,TNR,TRPM2,C1QL1,CALCRL,ITGB3,SLC5A7,PTGIR,FRRS1,TSG101,ANGPT2,TRAF3IP2,CUBN,ANK1,XPO7,P2rx7,PLIN2,ANGPTL3,NLGN2,SLC16A7,ABCA3,NUBP1,SLC16A4,POU3F3 33 Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities, Reproductive System Disease gonadal tumor Gonadal tumor 2.76E-03 KRT8,LRP5,ZMYM1,FAM234B,CSMD3,GLB1,PLG,AOC1,PKD1L2,AKNA,TNR,RRM2,TKFC,CHRNB3,DDX20,TRIM36,CASP2,HSPA12B,TSG101,LRP4,ANGPT2,TENM3,CUBN,ALDH7A1,XPO7,TULP4,WRN,FCGBP,PTK7,FAT4,PTPRG,ABCA3,TNXB,NCAN,ANKRD50,HNRNPM,HSD3B2,SCARF2 38 Organismal Development, Organismal Injury and Abnormalities abnormal morphology Abnormal morphology of abdomen 2.80E-03 KRT8,LRP4,LRP5,TRAF3IP2,LGMN,EMX2,TNFSF14,ABCA5,MFSD1,TMPRSS6,PLG,B4GALT1,RRM2,AGA,FAT4,ITGB3,LRP6,SCARF1,CASP2,PTGIR,COLEC11,POU3F3 22 Embryonic Development, Organ Development, Organismal Development, Renal and Urological System Development and Function, Tissue Development morphogenesis Morphogenesis of metanephric bud 2.80E-03 LRP4,FAT4,EMX2,ADAMTS16 4 Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry quantity Quantity of steroid 2.85E-03 -0.411 -0.405 LRP5,ANGPT2,FASN,CACFD1,DGAT1,PLIN2,ANGPTL3,PLG,WRN,PNLIP,FGL1,ITGB3,CASP2,PTGIR 14 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities lymphoma Lymphoma 2.92E-03 LGMN,FASN,ADAMTS16,CSMD3,PLG,BIRC3,BBX,RRM2,SYCE2,CALCRL,PGK1,ITGB3,SLC5A7,LRP6,VWDE,CASP2,ANOS1,MEGF6,ANGPT2,CUBN,SVEP1,BCHE,POLI,PTPRK,FAT4,MMRN2,IFI44,TNXB,NCAN,RRP12,ANKRD50,NUBP1,HNRNPM,L1CAM 34 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities non-Hodgkin disease Non-Hodgkin lymphoma 2.92E-03 LGMN,FASN,ADAMTS16,CSMD3,PLG,BBX,BIRC3,RRM2,CALCRL,PGK1,ITGB3,SLC5A7,LRP6,VWDE,CASP2,ANOS1,MEGF6,ANGPT2,CUBN,SVEP1,BCHE,PTPRK,FAT4,IFI44,TNXB,NCAN,ANKRD50,NUBP1,HNRNPM,L1CAM 30 Cancer, Organismal Injury and Abnormalities malignant neoplasm of connective or soft tissue of abdomen Malignant neoplasm of connective or soft tissue of abdomen 3.02E-03 KRT8,LRP4,ANGPT2,ANK1,MFSD1,CSMD3,PLG,SERINC2,PIF1,RRM2,FAT4,ABCA3,PGK1,VWDE,RABL2B,POU3F3 16 Dermatological Diseases and Conditions, Hair and Skin Development and Function, Organ Morphology, Organismal Injury and Abnormalities abnormal morphology Abnormal morphology of hair 3.08E-03 CELSR1,AGA,TMPRSS6,DGAT1,B4GALT1 5 Nucleic Acid Metabolism, Small Molecule Biochemistry synthesis Synthesis of nucleotide 3.10E-03 -0.775 -0.646 RRM2,C1QL1,ANGPT2,LGMN,CALCRL,DUT,FASN,PGK1,CASP2,PLG,PTGIR 11 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities gastric adenocarcinoma Gastric adenocarcinoma 3.17E-03 LRP5,CALM1 (includes others),CHRNA10,FASN,ADAMTS16,TMPRSS6,CSMD3,BIRC3,AKNA,C1QL1,FLNC,LRP6,RRP36,HCRTR2,VWDE,CASP2,DDO,ANOS1,MEGF6,ANGPT2,TENM3,CUBN,SVEP1,ANK1,XPO7,CACFD1,KMT5A,ACAA1,FAM111A,WRN,FCGBP,PTPRK,FAT4,TNXB,SCARF1,TMEM161B,DPY19L3,CR1,THSD4,SLC16A4 40 Cell-To-Cell Signaling and Interaction, Nervous System Development and Function adhesion Adhesion of neuronal cells 3.23E-03 NLGN2,LRP4,TNR,NCAN 4 Cell-To-Cell Signaling and Interaction, Renal and Urological System Development and Function response Response of kidney cell lines 3.23E-03 -1.000 -0.842 BIRC2,TRIM56,TRIM36,BIRC3 4 Cellular Movement cell movement Cell movement 3.26E-03 Decreased -2.532 -2.248 KRT8,CLEC10A,CELSR1,LRP5,LGMN,SNAP25,GNAO1,FASN,LITAF,TRIM3,PLG,B4GALT1,TNR,TRPM2,CALCRL,CD209,FUT6,TRIM2,ITGB3,FLNC,LRP6,NANOS1,EMILIN2,MEGF10,PTGIR,CALML3,ANOS1,CEBPD,ANGPT2,TRAF3IP2,TNFSF14,PPP1CA,KMT5A,P2rx7,ANGPTL3,WRN,PTK7,SOD3,PTPRK,MMRN2,PTPRG,ADGRG6,KIFC1,CR1,SLC16A4,POU3F3,L1CAM 47 Digestive System Development and Function morphology Morphology of digestive system 3.31E-03 REG1A,KRT8,LRP4,LRP5,TRAF3IP2,LGMN,TNFSF14,ABCA5,MFSD1,TMPRSS6,ANGPTL3,PLG,B4GALT1,NLGN2,FAT4,PNLIP,FGL1,LRP6 18 Cell-To-Cell Signaling and Interaction, Hair and Skin Development and Function response Response of epithelial cell lines 3.38E-03 -1.000 -0.836 BIRC2,TRIM56,TRIM36,BIRC3 4 Cell Morphology, Cellular Assembly and Organization, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Nervous System Development and Function, Organismal Development, Tissue Development myelination Myelination of axons 3.44E-03 FASN,ADGRG6,L1CAM 3 Infectious Diseases, Organismal Injury and Abnormalities replication Replication of hepatitis B virus 3.44E-03 RRM2,KRT8,BIRC3 3 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities acute leukemia Acute leukemia 3.50E-03 KRT8,CELSR1,CHRNA10,ZMYM1,TMPRSS6,BBX,TNR,RRM2,CHRNB3,CALCRL,FGL1,ITGB3,FLNC,EMILIN2,RABL2B,SUSD2,LRP4,CACHD1,ANOS1,TENM3,TSNARE1,CUBN,SVEP1,ATL2,ANK1,ALDH7A1,XPO7,KMT5A,TULP4,FCGBP,PTK7,PTPRK,SLC16A7,FAT4,PTPRG,TNXB,NCAN,CR1,TSPEAR 39 Organismal Injury and Abnormalities, Renal and Urological Disease urination disorder Urination disorder 3.60E-03 -0.859 -1.012 AGA,ANGPT2,LGMN,SYCE2,CUBN,SNAP25,TNFSF14,SCARF1,CR1,B4GALT1 10 Organismal Injury and Abnormalities non-cancer pain Non-cancer pain 3.60E-03 CHRNB3,SNAP25,CHRNA10,ITGB3,ACAA1,PLG 6 Cardiovascular System Development and Function morphology Morphology of cardiovascular system 3.61E-03 BIRC2,FRRS1,TSG101,LRP5,ANGPT2,TRAF3IP2,SNAP25,ABCA5,PPP1CA,FASN,DGAT1,LITAF,BIRC3,TRPM2,CALCRL,FAT4,MMRN2,PGK1,ITGB3,FLNC,PTGIR,L1CAM 22 Digestive System Development and Function, Gastrointestinal Disease, Hepatic System Development and Function, Hepatic System Disease, Inflammatory Disease, Inflammatory Response, Organ Development, Organismal Injury and Abnormalities inflammation Inflammation of liver 3.62E-03 0.762 0.691 BIRC2,KRT8,CHRNA10,TNFSF14,PNLIP,FASN,CGAS,LRP6,CASP2,WRN,BIRC3 11 Cellular Development, Cellular Growth and Proliferation, Nervous System Development and Function, Tissue Development development Development of central nervous system cells 3.64E-03 0.000 0.135 NLGN2,MMRN2,FASN,P2rx7,L1CAM 5 Cancer, Organismal Injury and Abnormalities, Reproductive System Disease malignant mixed Mullerian tumor Malignant mixed Mullerian tumor in endometrium 3.66E-03 KRT8,LRP4,ANK1,MFSD1,CSMD3,PLG,SERINC2,PIF1,FAT4,ABCA3,PGK1,VWDE,RABL2B,POU3F3 14 Organismal Injury and Abnormalities, Renal and Urological Disease proteinuria Proteinuria 3.67E-03 -1.109 -1.195 ANGPT2,LGMN,CUBN,TNFSF14,SCARF1,CR1,B4GALT1 7 Organismal Injury and Abnormalities extraintestinal functional disorder Extraintestinal functional disorder 3.70E-03 TRAF3IP2,TSNARE1,CALCRL,SNAP25,CHRNA10,ABCA3,ITGB3,BCHE,HCRTR2,TMEM161B,POU3F3,SERINC2 12 Cellular Movement migration Migration of cells 3.77E-03 Decreased -2.200 -1.936 KRT8,CLEC10A,CELSR1,LRP5,LGMN,SNAP25,GNAO1,FASN,LITAF,PLG,B4GALT1,TNR,TRPM2,CALCRL,CD209,TRIM2,ITGB3,FLNC,LRP6,NANOS1,EMILIN2,MEGF10,PTGIR,CALML3,CEBPD,ANGPT2,TRAF3IP2,TNFSF14,PPP1CA,KMT5A,P2rx7,ANGPTL3,WRN,PTK7,SOD3,PTPRK,MMRN2,ADGRG6,KIFC1,CR1,SLC16A4,POU3F3,L1CAM 43 Embryonic Development, Organ Development, Organ Morphology, Organismal Development, Organismal Injury and Abnormalities, Reproductive System Development and Function, Reproductive System Disease, Tissue Development, Tissue Morphology abnormal morphology Abnormal morphology of mammary epithelium 3.77E-03 CEBPD,DGAT1 2 Cardiovascular System Development and Function, Cell-To-Cell Signaling and Interaction, Nervous System Development and Function, Organ Development, Skeletal and Muscular System Development and Function action potential Action potential of cardiomyocytes 3.77E-03 CALM1 (includes others),TMEM161B 2 Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders autosomal dominant distal myopathy Autosomal dominant distal myopathy 3.77E-03 FLNC,MATR3 2 Immunological Disease, Inflammatory Response, Organismal Injury and Abnormalities inflammation Inflammation of spleen 3.77E-03 BIRC2,BIRC3 2 Cardiovascular Disease, Organismal Injury and Abnormalities Raynaud disease Raynaud disease 3.77E-03 SNAP25,PTGIR 2 Organismal Injury and Abnormalities scar tissue Scar tissue 3.97E-03 SNAP25,FASN,PLG 3 Small Molecule Biochemistry synthesis Synthesis of amine 4.01E-03 LRP5,SULT1A2,ETNK1,SLC5A7,Cyp2d22 5 Hematological System Development and Function hematocrit Hematocrit 4.27E-03 0.600 0.746 CLEC10A,LGMN,ITGB3,TMPRSS6,B4GALT1 5 Cell Death and Survival apoptosis Apoptosis of tissue 4.39E-03 0.000 -0.120 BIRC2,KRT8,EMX2,PLIN2 4 Cancer, Neurological Disease, Organismal Injury and Abnormalities oligodendroglioma Oligodendroglioma 4.43E-03 ZSWIM9,CLEC10A,LRP5,MFSD1,DGAT1,BBX,PKD1L2,AOC1,SERINC2,TRPM2,PGK1,FLNC,MEGF10,CACHD1,LRP4,TENM3,SVEP1,ANK1,PDZD7,WRN,PTK7,TRIM56,CCDC13,PTPRK,SLC16A7,FAT4,ABCA3,ADGRG6,NUBP1,THSD4,TSPEAR 31 Cardiovascular Disease, Organismal Injury and Abnormalities, Respiratory Disease acute pulmonary embolism Acute pulmonary embolism 4.44E-03 PTGIR,PLG 2 Cell-To-Cell Signaling and Interaction aggregation Aggregation of carcinoma cell lines 4.44E-03 NANOS1,L1CAM 2 Tissue Development formation Formation of elastic fibers 4.44E-03 TNXB,THSD4 2 Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities granulocytosis Granulocytosis 4.44E-03 BIRC2,BIRC3 2 Lipid Metabolism, Small Molecule Biochemistry incorporation Incorporation of palmitic acid 4.44E-03 ABCA3,DGAT1 2 Lipid Metabolism, Small Molecule Biochemistry incorporation Incorporation of triacylglycerol 4.44E-03 DGAT1,PLIN2 2 Nucleic Acid Metabolism, Small Molecule Biochemistry synthesis Synthesis of deoxyribonucleotide 4.44E-03 RRM2,DUT 2 Developmental Disorder, Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders familial congenital myopathy Familial congenital myopathy 4.54E-03 LRP4,CELSR1,SNAP25,SLC5A7,MEGF10 5 Cell Morphology, Connective Tissue Development and Function, Connective Tissue Disorders, Organismal Injury and Abnormalities, Tissue Morphology abnormal morphology Abnormal morphology of adipocytes 4.55E-03 CEBPD,FGL1,PLIN2 3 Organismal Development, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders, Skeletal and Muscular System Development and Function abnormal morphology Abnormal morphology of hindlimb 4.55E-03 LRP4,FLNC,LRP6 3 Behavior thigmotaxis Thigmotaxis 4.55E-03 NLGN2,LRP5,L1CAM 3 Cell-To-Cell Signaling and Interaction, Hematological System Development and Function binding Binding of leukocytes 4.55E-03 -0.918 -0.742 TNR,CLEC10A,ANGPT2,TRAF3IP2,CD209,TNFSF14,ITGB3,CR1,PLG,B4GALT1,L1CAM 11 Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking cellular infiltration Cellular infiltration by leukocytes 4.70E-03 Decreased -2.193 -2.148 LRP5,ANGPT2,TRAF3IP2,FASN,PLG,WRN,B4GALT1,TRPM2,SOD3,ITGB3,LRP6,CR1,PTGIR 13 Cancer, Neurological Disease, Organismal Injury and Abnormalities glioma Grade 2-3 glioma 4.73E-03 KRT8,ZSWIM9,CLEC10A,LRP5,MFSD1,DGAT1,BBX,PKD1L2,AOC1,TRPM2,PGK1,FLNC,MEGF10,CACHD1,LRP4,TENM3,SVEP1,ANK1,PDZD7,WRN,PTK7,TRIM56,CCDC13,PTPRK,SLC16A7,FAT4,ABCA3,ADGRG6,NUBP1,THSD4,TSPEAR 31 Cardiovascular Disease, Cardiovascular System Development and Function, Organismal Injury and Abnormalities abnormal morphology Abnormal morphology of cardiovascular system 4.75E-03 BIRC2,FRRS1,TSG101,LRP5,ANGPT2,TRAF3IP2,SNAP25,ABCA5,PPP1CA,FASN,LITAF,BIRC3,TRPM2,CALCRL,FAT4,MMRN2,PGK1,ITGB3,FLNC,PTGIR 20 Cancer, Organismal Injury and Abnormalities malignant neoplasm of connective or soft tissue of pelvis Malignant neoplasm of connective or soft tissue of pelvis 4.78E-03 KRT8,LRP4,ANK1,MFSD1,CSMD3,PLG,SERINC2,PIF1,RRM2,FAT4,ABCA3,PGK1,VWDE,RABL2B,POU3F3 15 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities acute lymphoblastic leukemia Acute lymphoblastic leukemia 4.79E-03 KRT8,CELSR1,CACHD1,LRP4,ANOS1,TENM3,TSNARE1,SVEP1,CHRNA10,ANK1,TMPRSS6,FCGBP,BBX,RRM2,PTPRK,SLC16A7,FAT4,PTPRG,FGL1,ITGB3 20 Cardiovascular System Development and Function vascularization Vascularization 4.84E-03 -1.000 -0.896 RRM2,LRP5,ANGPT2,MMRN2,ITGB3,PLG,B4GALT1,PTK7 8 Embryonic Development, Organ Development, Organ Morphology, Organismal Development, Organismal Injury and Abnormalities, Reproductive System Development and Function, Reproductive System Disease, Tissue Development abnormal morphology Abnormal morphology of mammary gland 4.85E-03 CEBPD,DGAT1,PLG 3 Gastrointestinal Disease, Hepatic System Disease, Inflammatory Disease, Organismal Injury and Abnormalities primary sclerosing cholangitis Primary sclerosing cholangitis 4.85E-03 BIRC2,CASP2,BIRC3 3 Cancer, Hematological Disease, Organismal Injury and Abnormalities Philadelphia chromosome negative chronic myeloproliferative neoplasm Philadelphia chromosome negative chronic myeloproliferative neoplasm 4.86E-03 RRM2,CEBPD,FAT4,ETNK1,ITGB3,SERINC2 6 Cardiovascular Disease, Hereditary Disorder, Organismal Injury and Abnormalities familial vascular disease Familial vascular disease 4.92E-03 RRM2,ANGPT2,ITGB3,LRP6,THSD4,PLG,PTGIR 7 Organismal Development, Organismal Injury and Abnormalities abnormal morphology Abnormal morphology of thoracic cavity 5.00E-03 BIRC2,FRRS1,TSG101,ANGPT2,TRAF3IP2,TNFSF14,ABCA5,PPP1CA,FASN,LITAF,PLG,B4GALT1,BIRC3,TRPM2,CALCRL,FAT4,ABCA3,PGK1,ITGB3,FLNC,PTGIR 21 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities B-cell non-Hodgkin disease B-cell non-Hodgkin lymphoma 5.04E-03 LGMN,CUBN,SVEP1,FASN,BCHE,BIRC3,RRM2,CALCRL,FAT4,TNXB,PGK1,NCAN,ITGB3,SLC5A7,LRP6,ANKRD50,NUBP1,HNRNPM,VWDE,CASP2,L1CAM 21 Cancer, Neurological Disease, Organismal Injury and Abnormalities brain oligodendroglioma Brain oligodendroglioma 5.10E-03 ZSWIM9,CLEC10A,LRP5,MFSD1,DGAT1,BBX,PKD1L2,AOC1,TRPM2,PGK1,FLNC,MEGF10,CACHD1,LRP4,TENM3,SVEP1,ANK1,PDZD7,WRN,PTK7,TRIM56,CCDC13,PTPRK,SLC16A7,FAT4,ABCA3,ADGRG6,NUBP1,THSD4,TSPEAR 30 Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry release Release of cholesterol 5.15E-03 FASN,PLG 2 Embryonic Development, Organ Development, Organismal Development, Renal and Urological System Development and Function, Tissue Development branching morphogenesis Branching morphogenesis of metanephric bud 5.17E-03 LRP4,FAT4,EMX2 3 Embryonic Development, Organismal Development, Tissue Development expansion Expansion of embryonic tissue 5.17E-03 LRP5,LRP6,PLG 3 Organismal Injury and Abnormalities pelvic pain Pelvic pain 5.17E-03 CHRNB3,SNAP25,CHRNA10 3 Cell Death and Survival, Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities apoptosis Apoptosis of liver cells 5.34E-03 1.387 1.355 BIRC2,KRT8,TNFSF14,ITGB3,PLG,BIRC3 6 Cellular Movement dissemination Dissemination of cells 5.38E-03 -1.969 -1.978 ANGPT2,CEBPD,EMILIN2,L1CAM 4 Lipid Metabolism, Small Molecule Biochemistry, Vitamin and Mineral Metabolism metabolism Metabolism of cholesterol 5.43E-03 LRP5,ABCA5,FGL1,CYP39A1,ANGPTL3 5 Lipid Metabolism, Small Molecule Biochemistry metabolism Fatty acid metabolism 5.48E-03 -1.491 -1.292 ABCA5,FASN,DGAT1,ACAA1,PLIN2,ANGPTL3,PLG,B4GALT1,Cyp2d22,CD209,ABCA3,FUT6,TNXB,ITGB3,C1QTNF3 15 Tissue Development branching Branching of epithelial tissue 5.59E-03 ANGPT2,PPP1CA,ITGB3,PLG,B4GALT1 5 Cell-To-Cell Signaling and Interaction, Cellular Assembly and Organization cell-cell contact Cell-cell contact 5.62E-03 -0.402 -0.206 LRP4,ANGPT2,LGMN,TNFSF14,FASN,B4GALT1,NLGN2,TNR,CD209,FAT4,TNXB,NCAN,ITGB3,FLNC,SLC5A7,LRP6,PTGIR,L1CAM,SCARF2 19 Developmental Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders congenital myopathy Congenital myopathy 5.73E-03 LRP4,CELSR1,SNAP25,FLNC,SLC5A7,MEGF10 6 Hematological System Development and Function mean corpuscular hemoglobin concentration Mean corpuscular hemoglobin concentration 5.84E-03 CLEC10A,LGMN,TMPRSS6 3 Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Inflammatory Response binding Binding of professional phagocytic cells 5.88E-03 -0.491 -0.368 TNR,CLEC10A,ANGPT2,CD209,ITGB3,PLG,B4GALT1 7 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities mature B cell malignant tumor Mature B cell malignant tumor 5.90E-03 KRT8,LGMN,FASN,BIRC3,RRM2,CALCRL,PGK1,ITGB3,SLC5A7,LRP6,VWDE,CASP2,FRRS1,CEBPD,CUBN,SVEP1,BCHE,FAT4,TNXB,NCAN,ANKRD50,NUBP1,HNRNPM,CR1,L1CAM 25 Cell Death and Survival, Organismal Injury and Abnormalities apoptosis Apoptosis of monocyte-derived macrophages 5.91E-03 BIRC2,BIRC3 2 Gastrointestinal Disease, Organismal Injury and Abnormalities dysphagia Dysphagia 5.91E-03 SNAP25,MEGF10 2 Cellular Movement, Skeletal and Muscular System Development and Function migration Migration of myoblasts 5.91E-03 MEGF10,PTGIR 2 Cellular Assembly and Organization, Cellular Function and Maintenance release Release of exosomes 5.91E-03 RAB11A,ABCA3 2 Developmental Disorder, Hereditary Disorder, Metabolic Disease, Organismal Injury and Abnormalities inborn error of metabolism Autosomal recessive inborn error of metabolism 5.99E-03 REG1A,TNXB,BCHE,PLG,GLB1,WRN 6 Organismal Injury and Abnormalities, Renal and Urological Disease proximal tubular toxicity Proximal tubular toxicity 6.04E-03 SLC16A7,FASN,ACAA1,Cyp2d22 4 Cancer, Cell Death and Survival, Organismal Injury and Abnormalities, Tumor Morphology necrosis Necrosis of tumor 6.08E-03 Increased 2.157 2.106 REG1A,BIRC2,TSG101,RRM2,ANGPT2,CEBPD,FASN,C1QTNF4,CASP2,PLG,L1CAM,BIRC3 12 Cancer, Neurological Disease, Organismal Injury and Abnormalities malignant glioma Grade 3 malignant glioma 6.09E-03 ZSWIM9,CLEC10A,LRP5,MFSD1,DGAT1,BBX,PKD1L2,AOC1,TRPM2,PGK1,FLNC,MEGF10,CACHD1,LRP4,TENM3,SVEP1,ANK1,PDZD7,WRN,PTK7,TRIM56,CCDC13,PTPRK,SLC16A7,FAT4,ABCA3,ADGRG6,NUBP1,THSD4,TSPEAR 30 Lipid Metabolism, Small Molecule Biochemistry metabolism Metabolism of sphingolipid 6.13E-03 -1.103 -0.960 FUT6,ABCA3,FASN,GLB1,B4GALT1,SERINC2 6 Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry concentration Concentration of acylglycerol 6.18E-03 0.462 0.476 LRP5,GNAO1,FASN,FGL1,CACFD1,DGAT1,BCHE,PLIN2,ANGPTL3,CASP2,WRN 11 Cancer, Neurological Disease, Organismal Injury and Abnormalities gliomatosis cerebri cancer Gliomatosis cerebri 6.21E-03 KRT8,CLEC10A,LRP5,MFSD1,FASN,HARBI1,FAM234B,DGAT1,GLB1,BBX,SERINC2,TRIM2,ITGB3,AIMP2,FLNC,CYP39A1,LRP6,SNX33,MEGF11,MEGF10,CSRNP3,REG1A,FRRS1,TSG101,CACHD1,RNF207,MKX,CUBN,SVEP1,ATL2,ANK1,TNFSF14,PDZD7,TULP4,FAM111A,WRN,NLGN2,PRKCSH,NCAN,HNRNPM,DPY19L3,TTC24,SLC16A4 43 Digestive System Development and Function, Gastrointestinal Disease, Organ Morphology, Organismal Development, Organismal Injury and Abnormalities abnormal morphology Abnormal morphology of intestine 6.23E-03 KRT8,LRP5,FAT4,TNFSF14,LRP6,PLG,B4GALT1 7 Nucleic Acid Metabolism, Small Molecule Biochemistry biosynthesis Biosynthesis of cyclic nucleotides 6.23E-03 -0.059 0.044 C1QL1,ANGPT2,LGMN,CALCRL,CASP2,PLG,PTGIR 7 Cellular Development, Cellular Growth and Proliferation, Tissue Development development Development of epithelial cells 6.27E-03 -0.903 -0.795 KRT8,GNAO1,ABCA3,ADRM1,PLG,B4GALT1 6 Cellular Function and Maintenance internalization Internalization of leukemia cell lines 6.56E-03 CD209,SCARF1,PLG 3 Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities, Reproductive System Disease testicular teratoma Testicular teratoma 6.56E-03 AKNA,TKFC,WRN 3 Cellular Movement, Hematological System Development and Function, Immune Cell Trafficking cellular infiltration Cellular infiltration by granulocytes 6.57E-03 -0.943 -0.880 TRPM2,ANGPT2,TRAF3IP2,CR1,PLG,PTGIR,WRN,B4GALT1 8 Nutritional Disease, Organismal Injury and Abnormalities weight gain Weight gain 6.61E-03 DDO,AGA,LGMN,SNAP25,PNLIP,FASN,FGL1,BCHE,L1CAM,AOC1 10 Cellular Function and Maintenance, Hematological System Development and Function function Function of macrophages 6.70E-03 TRPM2,LGMN,ITGB3,SCARF1,PLG,BIRC3 6 Cell-mediated Immune Response, Lymphoid Tissue Structure and Development frequency Frequency of Th17 cells 6.72E-03 LRP5,LRP6 2 Neurological Disease, Organismal Injury and Abnormalities, Psychological Disorders nicotine withdrawal syndrome Nicotine withdrawal syndrome 6.72E-03 CHRNB3,CHRNA10 2 DNA Replication, Recombination, and Repair, Energy Production, Nucleic Acid Metabolism, Small Molecule Biochemistry oxidation Oxidation of NADPH 6.72E-03 CALM1 (includes others),FASN 2 Lipid Metabolism, Small Molecule Biochemistry metabolism Metabolism of glycosphingolipid 6.75E-03 FUT6,ABCA3,GLB1,B4GALT1 4 Infectious Diseases, Organismal Injury and Abnormalities replication Replication of virus 6.88E-03 -0.177 -0.023 KRT8,TSG101,RAB11A,FASN,HARBI1,PLG,WRN,BIRC3,RSL24D1,RRM2,TRIM56,CD209,HNRNPM,CASP2 14 Cancer, Neurological Disease, Organismal Injury and Abnormalities glioblastoma cancer Glioblastoma 6.89E-03 NLGN2,FRRS1,RRM2,ANGPT2,GNAO1,FASN,PGK1,ITGB3,CASP2,FAM111A,GLB1,SERINC2 12 Cell Death and Survival, Embryonic Development apoptosis Apoptosis of embryonic tissue 6.94E-03 BIRC2,EMX2,PLIN2 3 Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities, Reproductive System Disease endometrioid ovarian cancer Ovarian endometrioid carcinoma 7.06E-03 TENM3,CUBN,TULP4,CSMD3,GLB1,AKNA,TNR,RRM2,CHRNB3,FAT4,PTPRG,ABCA3,TNXB,NCAN,HNRNPM,HSD3B2,CASP2,TRIM36,HSPA12B,SCARF2 20 Nucleic Acid Metabolism, Small Molecule Biochemistry metabolism Metabolism of nucleotide 7.12E-03 -0.775 -0.643 RRM2,C1QL1,ANGPT2,LGMN,CALCRL,DUT,SULT1A2,FASN,PGK1,CASP2,PLG,PTGIR 12 Cell-To-Cell Signaling and Interaction, Hematological System Development and Function, Immune Cell Trafficking adhesion Adhesion of immune cells 7.25E-03 -1.474 -1.307 TNR,CLEC10A,ANGPT2,TRAF3IP2,CD209,ITGB3,CR1,PLG,B4GALT1,L1CAM 10 Tissue Development organization Organization of extracellular matrix 7.37E-03 TNR,TNXB,TMPRSS6,PLG,B4GALT1 5 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities B-cell leukemia B-cell leukemia 7.39E-03 KRT8,CELSR1,CACHD1,LRP4,ANOS1,TENM3,TSNARE1,SVEP1,CHRNA10,ANK1,PPP1CA,TMPRSS6,FCGBP,BBX,BIRC3,RRM2,SLC16A7,FAT4,PTPRG,ITGB3 20 Organismal Injury and Abnormalities, Organismal Survival neonatal death Neonatal death 7.41E-03 0.419 0.042 NLGN2,LRP4,CEBPD,SNAP25,FAT4,EMX2,ABCA3,FLNC,LRP6,POU3F3,B4GALT1 11 Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry uptake Uptake of lipid 7.47E-03 -0.364 -0.210 RAB11A,CUBN,ABCA3,PNLIP,DGAT1,PLIN2 6 Connective Tissue Development and Function, Tissue Morphology mass Mass of connective tissue 7.50E-03 LRP4,LRP5,CEBPD,DGAT1,ANGPTL3,PLIN2,WRN 7 Hematological Disease, Organismal Injury and Abnormalities polycythemia Polycythemia 7.50E-03 1.982 1.920 BIRC2,CLEC10A,RRM2,TRAF3IP2,FAT4,BIRC3,SERINC2 7 Neurological Disease, Organismal Injury and Abnormalities, Psychological Disorders delirium Delirium 7.51E-03 CHRNB3,CHRNA10,BCHE,HCRTR2 4 Cancer, Endocrine System Disorders, Organismal Injury and Abnormalities, Reproductive System Disease ovarian adenocarcinoma Ovarian adenocarcinoma 7.56E-03 KRT8,ZMYM1,FAM234B,CSMD3,GLB1,AKNA,TNR,RRM2,CHRNB3,DDX20,TRIM36,CASP2,HSPA12B,LRP4,TENM3,CUBN,ALDH7A1,XPO7,TULP4,FCGBP,PTK7,FAT4,PTPRG,ABCA3,TNXB,NCAN,ANKRD50,HNRNPM,HSD3B2,SCARF2 30 Cellular Movement, Immune Cell Trafficking migration Leukocyte migration 7.57E-03 Decreased -2.634 -2.449 CLEC10A,LRP5,ANGPT2,TRAF3IP2,LGMN,GNAO1,TNFSF14,FASN,LITAF,PLG,WRN,B4GALT1,TNR,TRPM2,SOD3,CD209,ITGB3,ADGRG6,LRP6,CR1,PTGIR 21 Reproductive System Development and Function composition Composition of breast milk 7.58E-03 DGAT1,B4GALT1 2 Lipid Metabolism, Small Molecule Biochemistry incorporation Incorporation of oleic acid 7.58E-03 DGAT1,PLIN2 2 Cancer, Hematological Disease, Immunological Disease, Organismal Injury and Abnormalities chronic lymphocytic leukemia Relapsed chronic lymphocytic leukemia 7.58E-03 RRM2,BIRC3 2 Lipid Metabolism, Small Molecule Biochemistry synthesis Synthesis of cerebroside 7.58E-03 ABCA3,B4GALT1 2 Behavior associative learning Associative learning 7.74E-03 TNR,LGMN,SNAP25 3 Cell Death and Survival apoptosis Delay in apoptosis 7.74E-03 BIRC2,CASP2,BIRC3 3 Cancer, Developmental Disorder, Endocrine System Disorders, Hereditary Disorder, Metabolic Disease, Organismal Injury and Abnormalities 3 beta hydroxysteroid dehydrogenase deficiency 3 beta hydroxysteroid dehydrogenase deficiency 7.78E-03 HSD3B2 1 Hereditary Disorder, Neurological Disease, Ophthalmic Disease, Organismal Injury and Abnormalities 3-methylglutaconic aciduria with cataracts, neurologic involvement, and neutropenia 3-methylglutaconic aciduria with cataracts, neurologic involvement, and neutropenia 7.78E-03 CLPB 1 Connective Tissue Disorders, Embryonic Development, Organ Development, Organ Morphology, Organismal Development, Organismal Injury and Abnormalities, Reproductive System Development and Function, Reproductive System Disease, Tissue Development, Tissue Morphology abnormal morphology Abnormal morphology of mammary gland connective tissue 7.78E-03 PLG 1 Dermatological Diseases and Conditions, Organismal Injury and Abnormalities shedding Abnormal shedding of hair 7.78E-03 DGAT1 1 Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry accumulation Accumulation of asialo GM1 ganglioside 7.78E-03 GLB1 1 Embryonic Development, Tissue Development accumulation Accumulation of embryonic stem cells 7.78E-03 KMT5A 1 Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry accumulation Accumulation of ganglioside GD1a 7.78E-03 GLB1 1 Carbohydrate Metabolism, Molecular Transport, Small Molecule Biochemistry accumulation Accumulation of keratan sulfate 7.78E-03 GLB1 1 Tissue Development accumulation Accumulation of splenocytes 7.78E-03 CASP2 1 Ophthalmic Disease, Organismal Injury and Abnormalities acquired esotropia Acquired esotropia 7.78E-03 SNAP25 1 Cancer, Cell-To-Cell Signaling and Interaction, Organismal Injury and Abnormalities activation Activation of erythroleukemia cells 7.78E-03 PLG 1 Inflammatory Response, Tissue Development acute inflammatory response Acute inflammatory response of tissue 7.78E-03 B4GALT1 1 Cell-To-Cell Signaling and Interaction aggregation Aggregation of germ cell tumor cell lines 7.78E-03 L1CAM 1 Cardiovascular Disease, Organismal Injury and Abnormalities angiogenesis Angiogenesis of atherosclerotic lesion 7.78E-03 PLG 1 Cardiovascular System Development and Function, Cell Cycle mitosis Arrest in mitosis of endothelial cells 7.78E-03 PLG 1 Cell Cycle prometaphase Arrest in prometaphase of fibroblast cell lines 7.78E-03 KIFC1 1 Infectious Diseases, Organismal Injury and Abnormalities assembly Assembly of Marburg virus 7.78E-03 TSG101 1 Infectious Diseases, Organismal Injury and Abnormalities assembly Assembly of Sudan ebolavirus 7.78E-03 TSG101 1 Cellular Assembly and Organization assembly Assembly of brush border 7.78E-03 KRT8 1 Infectious Diseases, Organismal Injury and Abnormalities attachment Attachment of Dengue virus 7.78E-03 CD209 1 Infectious Diseases, Organismal Injury and Abnormalities attachment Attachment of Ebola virus 7.78E-03 CD209 1 Cell-To-Cell Signaling and Interaction, Skeletal and Muscular System Development and Function attachment Attachment of HCSM cells 7.78E-03 PLG 1 Infectious Diseases, Organismal Injury and Abnormalities attachment Attachment of cytomegalovirus 7.78E-03 CD209 1 Cell-To-Cell Signaling and Interaction, Skeletal and Muscular System Development and Function attachment Attachment of smooth muscle cell lines 7.78E-03 ITGB3 1 Cardiovascular Disease, Organismal Injury and Abnormalities autonomic dysreflexia Autonomic dysreflexia 7.78E-03 SNAP25 1 Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders Charcot-Marie-Tooth disease axonal type 1c Autosomal dominant Charcot-Marie-Tooth disease axonal type 1c 7.78E-03 LITAF 1 Cardiovascular Disease, Hereditary Disorder, Organismal Injury and Abnormalities autosomal dominant coronary artery disease type 2 Autosomal dominant coronary artery disease type 2 7.78E-03 LRP6 1 Hereditary Disorder, Ophthalmic Disease, Organismal Injury and Abnormalities autosomal dominant exudative vitreoretinopathy type 4 Autosomal dominant exudative vitreoretinopathy type 4 7.78E-03 LRP5 1 Connective Tissue Disorders, Developmental Disorder, Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders autosomal dominant osteopetrosis type 1 Autosomal dominant osteopetrosis type 1 7.78E-03 LRP5 1 Developmental Disorder, Hereditary Disorder, Metabolic Disease, Neurological Disease, Organismal Injury and Abnormalities GM1 gangliosidosis type 2 Autosomal recessive GM1 gangliosidosis type 2 7.78E-03 GLB1 1 Dermatological Diseases and Conditions, Developmental Disorder, Hereditary Disorder, Metabolic Disease, Organismal Injury and Abnormalities Werner syndrome Autosomal recessive Werner syndrome 7.78E-03 WRN 1 Developmental Disorder, Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities autosomal recessive anencephaly Autosomal recessive anencephaly 7.78E-03 TRIM36 1 Auditory Disease, Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities autosomal recessive deafness type 57 Autosomal recessive deafness type 57 7.78E-03 PDZD7 1 Auditory Disease, Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities autosomal recessive deafness type 98 Autosomal recessive deafness type 98 7.78E-03 TSPEAR 1 Hereditary Disorder, Ophthalmic Disease, Organismal Injury and Abnormalities autosomal recessive exudative vitreoretinopathy type 4 Autosomal recessive exudative vitreoretinopathy type 4 7.78E-03 LRP5 1 Connective Tissue Disorders, Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders osteoporosis-pseudoglioma syndrome Autosomal recessive osteoporosis-pseudoglioma syndrome 7.78E-03 LRP5 1 Cardiovascular Disease, Cell Death and Survival, Connective Tissue Disorders, Developmental Disorder, Hematological Disease, Hereditary Disorder, Organismal Injury and Abnormalities autosomal recessive spherocytosis type 1 Autosomal recessive spherocytosis type 1 7.78E-03 ANK1 1 Developmental Disorder, Hereditary Disorder, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders syndactyly type VII Autosomal recessive syndactyly type VII 7.78E-03 LRP4 1 Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders axonal Charcot-Marie-Tooth disease type 2R Axonal Charcot-Marie-Tooth disease type 2R 7.78E-03 TRIM2 1 Cell-To-Cell Signaling and Interaction binding Binding of Bacille Calmette-Guerin 7.78E-03 CD209 1 Infectious Diseases, Organismal Injury and Abnormalities binding Binding of human herpesvirus 8 7.78E-03 CD209 1 Inflammatory Disease, Neurological Disease, Organismal Injury and Abnormalities brain abscess Brain abscess 7.78E-03 ANGPT2 1 Cell Morphology, Cellular Assembly and Organization, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Embryonic Development, Nervous System Development and Function, Organismal Development, Tissue Development branching Branching of primary axons 7.78E-03 KIFC1 1 Cell Morphology, Cellular Assembly and Organization, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Embryonic Development, Nervous System Development and Function, Organismal Development, Tissue Development branching Branching of secondary axons 7.78E-03 KIFC1 1 Cell Morphology, Cellular Assembly and Organization, Cellular Development, Cellular Function and Maintenance, Cellular Growth and Proliferation, Embryonic Development, Nervous System Development and Function, Organismal Development, Tissue Development branching Branching of tertiary axons 7.78E-03 KIFC1 1 Neurological Disease, Organismal Injury and Abnormalities breakdown Breakdown of axons 7.78E-03 CR1 1 Cell Morphology, Cellular Assembly and Organization, Cellular Function and Maintenance budding Budding of clathrin-coated pits 7.78E-03 ANK1 1 Developmental Disorder, Hereditary Disorder, Neurological Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders CRASH syndrome CRASH syndrome 7.78E-03 L1CAM 1 Small Molecule Biochemistry, Vitamin and Mineral Metabolism catabolism Catabolism of cyanocobalamin 7.78E-03 CUBN 1 Cardiovascular Disease, Hereditary Disorder, Organismal Injury and Abnormalities catecholaminergic polymorphic ventricular tachycardia type 4 Catecholaminergic polymorphic ventricular tachycardia type 4 7.78E-03 CALM1 (includes others) 1 Cell Cycle cell division Cell division of neural stem cells 7.78E-03 EMX2 1 Cancer, Cell Death and Survival, Organismal Injury and Abnormalities, Tumor Morphology cell viability Cell viability of mammary tumor cells 7.78E-03 CEBPD 1 Cell Cycle, Cell Death and Survival, Embryonic Development chromosome condensation Chromosome condensation of embryonic stem cells 7.78E-03 KMT5A 1 Hereditary Disorder, Organismal Injury and Abnormalities, Renal and Urological Disease chronic benign proteinuria Chronic benign proteinuria 7.78E-03 CUBN 1 Cellular Growth and Proliferation clonogenicity Clonogenicity of fibrosarcoma cell lines 7.78E-03 EMILIN2 1 Cell-To-Cell Signaling and Interaction, Nervous System Development and Function conduction Conduction of neuroglia 7.78E-03 TNR 1 Developmental Disorder, Hereditary Disorder, Metabolic Disease, Organismal Injury and Abnormalities congenital disorder of glycosylation type 2d Congenital disorder of glycosylation type 2d 7.78E-03 B4GALT1 1 Developmental Disorder, Hereditary Disorder, Immunological Disease, Neurological Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders congenital myasthenic syndrome type 17 Congenital myasthenic syndrome type 17 7.78E-03 LRP4 1 Developmental Disorder, Hereditary Disorder, Immunological Disease, Neurological Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders congenital myasthenic syndrome type 18 Congenital myasthenic syndrome type 18 7.78E-03 SNAP25 1 Immunological Disease, Organismal Injury and Abnormalities contact hypersensitivity Contact hypersensitivity of tissue 7.78E-03 B4GALT1 1 Organismal Injury and Abnormalities conventional nevus Conventional nevus 7.78E-03 FASN 1 Nervous System Development and Function decussation Decussation 7.78E-03 L1CAM 1 Gastrointestinal Disease, Hepatic System Disease, Organismal Injury and Abnormalities defenestration Defenestration of sinusoidal lining 7.78E-03 WRN 1 Organ Morphology deformation Deformation of skin 7.78E-03 TNXB 1 Connective Tissue Disorders, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders degenerative lumbar spinal stenosis Degenerative lumbar spinal stenosis 7.78E-03 PLG 1 Cell-To-Cell Signaling and Interaction, Embryonic Development delamination Delamination of neuroblasts 7.78E-03 AKNA 1 Reproductive System Development and Function decidualization Delay in decidualization 7.78E-03 PLG 1 Cell Cycle, Embryonic Development cell cycle progression Delay in initiation of cell cycle progression of embryonic stem cells 7.78E-03 KMT5A 1 Cellular Assembly and Organization priming Delay in initiation of priming of vesicles 7.78E-03 SNAP25 1 Nervous System Development and Function remyelination Delay in initiation of remyelination of sciatic nerve 7.78E-03 ADGRG6 1 Immunological Disease, Organismal Injury and Abnormalities delayed hypersensitive reaction Delayed hypersensitive reaction of tissue 7.78E-03 B4GALT1 1 Cellular Assembly and Organization density Density of collagen fibrils 7.78E-03 TNXB 1 Cellular Compromise, Organ Morphology, Organismal Injury and Abnormalities, Tissue Morphology destruction Destruction of photoreceptors 7.78E-03 GLB1 1 Embryonic Development, Organ Development, Organismal Development, Renal and Urological System Development and Function, Tissue Development development Development of Henle's loop 7.78E-03 POU3F3 1 Embryonic Development, Organ Development, Organismal Development, Renal and Urological System Development and Function, Tissue Development development Development of distal convoluted tubule 7.78E-03 POU3F3 1 Embryonic Development, Nervous System Development and Function, Organ Development, Organismal Development, Tissue Development development Development of hippocampal fissure 7.78E-03 EMX2 1 Embryonic Development, Organ Development, Organismal Development, Renal and Urological System Development and Function, Tissue Development development Development of macula densa 7.78E-03 POU3F3 1 Gastrointestinal Disease, Hereditary Disorder, Organismal Injury and Abnormalities diarrhea type 7 Diarrhea type 7 7.78E-03 DGAT1 1 Hereditary Disorder, Ophthalmic Disease, Organismal Injury and Abnormalities digenic exudative vitreoretinopathy type 4 Digenic exudative vitreoretinopathy type 4 7.78E-03 LRP5 1 Cardiovascular Disease, Organismal Injury and Abnormalities, Skeletal and Muscular Disorders, Tissue Morphology disorganization Disorganization of myocardium 7.78E-03 CALCRL 1 Cell-To-Cell Signaling and Interaction disruption Disruption of actin filopodia 7.78E-03 PLG 1 Tox Functions for My Projects->Mac - Oyster RNA-Seq->20220810_NOPP-gigas-ploidy-temp_pval_only 10:49 AM->desiccation_ploidy Categories Functions Diseases or Functions Annotation p-Value Predicted Activation State Activation z-score Notes Bias-corrected z-score Molecules # Molecules Liver Hyperplasia/Hyperproliferation cancer Liver cancer 4.91E-08 -1.982 -2.048 BIRC2,KRT8,CELSR1,LRP5,LGMN,CHRNA10,SULT1A2,TMPRSS6,GLB1,PLG,SLC16A14,AOC1,AKNA,TNR,RRM2,TRPM2,TKFC,PNLIP,FGL1,FLNC,SLC5A7,CYP39A1,LRP6,ADRM1,HCRTR2,VWDE,SNX33,C1QTNF3,DDO,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,CACFD1,TULP4,NLGN2,SOD3,CCDC13,PTPRG,ABCA3,TNXB,NCAN,ANKRD50,HNRNPM,HSD3B2,THSD4,RASEF,CR1,TTC24,L1CAM,SCARF2,TSPEAR,ZSWIM9,GNAO1,ABCA5,ZMYM1,FASN,HARBI1,CSMD3,B4GALT1,PKD1L2,SERINC2,MAPK4,CALCRL,FUT6,TRIM2,PGK1,DDX20,CASP2,TRIM36,CSRNP3,SUSD2,LRP4,ANGPT2,TENM3,TSNARE1,CUBN,ANK1,BCHE,ACAA1,KMT5A,PLIN2,POLI,MB21D2,PRKCSH,FAT4,MMRN2,KIFC1,MMRN1 92 Liver Hyperplasia/Hyperproliferation liver tumor Liver tumor 1.50E-07 -1.982 -2.037 CELSR1,KRT8,LGMN,CHRNA10,SULT1A2,GLB1,SLC16A14,AOC1,TRPM2,TKFC,PNLIP,FGL1,LRP6,SNX33,C1QTNF3,CACFD1,NLGN2,PTPRG,TNXB,HSD3B2,THSD4,RASEF,CR1,TTC24,L1CAM,SCARF2,TSPEAR,GNAO1,FASN,HARBI1,B4GALT1,PKD1L2,SERINC2,MAPK4,CD209,CALCRL,DDX20,CSRNP3,LRP4,TENM3,ATL2,BCHE,PLIN2,POLI,MB21D2,MMRN2,MMRN1,BIRC2,HDHD5,LRP5,TMPRSS6,PLG,BBX,AKNA,TNR,RRM2,SYCE2,FLNC,SLC5A7,CYP39A1,ADRM1,HCRTR2,VWDE,DDO,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,TULP4,FCGBP,RSL24D1,SOD3,CCDC13,ABCA3,NCAN,ANKRD50,HNRNPM,ZSWIM9,ABCA5,ZMYM1,CSMD3,FUT6,TRIM2,PGK1,MEGF11,CASP2,TRIM36,SUSD2,ANGPT2,TSNARE1,CUBN,ANK1,ACAA1,KMT5A,PRKCSH,FAT4,KIFC1 100 Liver Hyperplasia/Hyperproliferation liver carcinoma Liver carcinoma 4.45E-07 BIRC2,CELSR1,KRT8,LRP5,LGMN,CHRNA10,SULT1A2,TMPRSS6,GLB1,PLG,SLC16A14,AOC1,AKNA,TNR,RRM2,TRPM2,TKFC,PNLIP,FGL1,FLNC,SLC5A7,CYP39A1,LRP6,ADRM1,HCRTR2,VWDE,SNX33,C1QTNF3,DDO,ANOS1,MKX,TRAF3IP2,SVEP1,MGAT4C,ALDH7A1,XPO7,CACFD1,TULP4,NLGN2,SOD3,CCDC13,PTPRG,ABCA3,TNXB,NCAN,ANKRD50,HNRNPM,HSD3B2,THSD4,RASEF,CR1,TTC24,SCARF2,TSPEAR,ZSWIM9,GNAO1,ABCA5,ZMYM1,FASN,HARBI1,CSMD3,PKD1L2,SERINC2,MAPK4,CALCRL,FUT6,TRIM2,PGK1,CASP2,TRIM36,CSRNP3,SUSD2,LRP4,TENM3,TSNARE1,CUBN,ANK1,BCHE,ACAA1,KMT5A,POLI,MB21D2,PRKCSH,FAT4,MMRN2,KIFC1,MMRN1 87 Liver Hyperplasia/Hyperproliferation polycystic liver disease 1 Polycystic liver disease 1 8.84E-04 LRP5,PRKCSH 2 Hepatocellular carcinoma, Liver Hyperplasia/Hyperproliferation hepatocellular carcinoma Hepatocellular carcinoma 9.12E-04 BIRC2,KRT8,GNAO1,FASN,TMPRSS6,CSMD3,GLB1,PLG,SERINC2,TNR,RRM2,TKFC,PGK1,FGL1,LRP6,CYP39A1,VWDE,CASP2,C1QTNF3,ANOS1,MKX,CUBN,SVEP1,XPO7,ACAA1,FAT4,PTPRG,KIFC1,RASEF,CR1,SCARF2,TSPEAR 32 Liver Hyperplasia/Hyperproliferation polycystic liver disease Polycystic liver disease 1.18E-03 PRKCSH,LRP5,LRP6 3 Liver Necrosis/Cell Death cell death Cell death of hepatocytes 1.28E-03 0.478 0.452 BIRC2,KRT8,TNFSF14,FASN,CR1,PLG,BIRC3 7 Liver Necrosis/Cell Death necrosis Necrosis of liver 1.29E-03 0.862 0.786 BIRC2,KRT8,AGA,TNFSF14,FASN,ITGB3,CR1,PLG,BIRC3 9 Liver Necrosis/Cell Death cell death Cell death of liver cells 1.32E-03 0.478 0.458 BIRC2,KRT8,TNFSF14,FASN,ITGB3,CR1,PLG,BIRC3 8 Liver Inflammation/Hepatitis inflammation Inflammation of liver 3.62E-03 0.762 0.691 BIRC2,KRT8,CHRNA10,TNFSF14,PNLIP,FASN,CGAS,LRP6,CASP2,WRN,BIRC3 11 Cardiac Pulmonary Embolism acute pulmonary embolism Acute pulmonary embolism 4.44E-03 PTGIR,PLG 2 Liver Necrosis/Cell Death apoptosis Apoptosis of liver cells 5.34E-03 1.387 1.355 BIRC2,KRT8,TNFSF14,ITGB3,PLG,BIRC3 6 Renal Damage, Renal Tubule Injury proximal tubular toxicity Proximal tubular toxicity 6.04E-03 SLC16A7,FASN,ACAA1,Cyp2d22 4 Increased Levels of Hematocrit hematocrit Increased Levels of Hematocrit 7.51E-03 0.218 0.446 LGMN,ITGB3,TMPRSS6,B4GALT1 4 Hepatocellular Peroxisome Proliferation activation Activation of PPARA in liver cells 7.78E-03 PLIN2 1 Cardiac Arteriopathy autosomal dominant coronary artery disease type 2 Autosomal dominant coronary artery disease type 2 7.78E-03 LRP6 1 Cardiac Arrythmia, Tachycardia catecholaminergic polymorphic ventricular tachycardia type 4 Catecholaminergic polymorphic ventricular tachycardia type 4 7.78E-03 CALM1 (includes others) 1 Renal Hyperplasia/Hyperproliferation hyperplasia Hyperplasia of proximal tubule cells 7.78E-03 LGMN 1 Cardiac Arrythmia, Congenital Heart Anomaly long QT syndrome type 14 Long QT syndrome type 14 7.78E-03 CALM1 (includes others) 1 Cardiac Arrythmia, Congenital Heart Anomaly long QT syndrome type 15 Long QT syndrome type 15 7.78E-03 CALM1 (includes others) 1 Cardiac Arrythmia, Congenital Heart Anomaly long QT syndrome type 16 Long QT syndrome type 16 7.78E-03 CALM1 (includes others) 1 Hepatocellular carcinoma, Liver Hyperplasia/Hyperproliferation moderately differentiated hepatocellular carcinoma Moderately differentiated hepatocellular carcinoma 7.78E-03 FGL1 1 Liver Hyperplasia/Hyperproliferation polycystic liver disease 1 without kidney cysts Polycystic liver disease 1 without kidney cysts 7.78E-03 PRKCSH 1 Liver Hyperplasia/Hyperproliferation polycystic liver disease 4 with or without kidney cysts Polycystic liver disease 4 with or without kidney cysts 7.78E-03 LRP5 1 Hepatocellular carcinoma, Liver Hyperplasia/Hyperproliferation hepatocellular carcinoma Well-differentiated hepatocellular carcinoma 7.78E-03 FGL1 1 Cardiac Inflammation inflammation Inflammation of heart 8.59E-03 TSG101,CGAS,WRN 3 Liver Necrosis/Cell Death focal necrosis Focal necrosis of liver 1.04E-02 AGA,PLG 2 Liver Necrosis/Cell Death apoptosis Apoptosis of hepatocytes 1.10E-02 1.387 1.359 BIRC2,KRT8,TNFSF14,PLG,BIRC3 5 Renal Atrophy atrophy Atrophy of renal tubule 1.15E-02 AGA,LGMN 2 Increased Levels of Red Blood Cells quantity Increased Levels of Red Blood Cells 1.25E-02 0.218 0.446 LGMN,ITGB3,TMPRSS6,B4GALT1 4 Renal Hyperplasia/Hyperproliferation hyperplasia Hyperplasia of kidney cells 1.37E-02 TRAF3IP2,LGMN 2 Cardiac Fibrosis perivascular fibrosis Perivascular fibrosis of heart 1.37E-02 ANGPT2,TRAF3IP2 2 Glomerular Injury abnormal morphology Abnormal morphology of renal glomerulus 1.45E-02 AGA,TRAF3IP2,LGMN,B4GALT1 4 Cardiac Pulmonary Embolism acute submassive pulmonary embolism Acute submassive pulmonary embolism 1.55E-02 PLG 1 Hepatocellular carcinoma, Liver Hyperplasia/Hyperproliferation hepatocellular carcinoma Poorly differentiated hepatocellular carcinoma 1.55E-02 FGL1 1 Liver Hyperplasia/Hyperproliferation hepatosplenic T-cell lymphoma Refractory hepatosplenic T-cell lymphoma 1.55E-02 RRM2 1 Liver Hyperplasia/Hyperproliferation hepatosplenic T-cell lymphoma Relapsed hepatosplenic T-cell lymphoma 1.55E-02 RRM2 1 Liver Cirrhosis, Liver Fibrosis susceptibility to noncryptogenic cirrhosis Susceptibility to noncryptogenic cirrhosis 1.55E-02 KRT8 1 Glomerular Injury, Kidney Failure, Renal Fibrosis interstitial fibrosis Interstitial fibrosis of kidney 2.01E-02 AGA,ANGPT2,LGMN 3 Cardiac Arteriopathy disorder of coronary artery Disorder of coronary artery 2.19E-02 ANGPT2,TSNARE1,ETNK1,ITGB3,LRP6,ACAA1,PLG,PTGIR 8 Liver Cirrhosis, Liver Fibrosis cryptogenic cirrhosis Cryptogenic cirrhosis 2.32E-02 KRT8 1 Renal Dysfunction dysfunction Dysfunction of podocytes 2.32E-02 ANGPT2 1 Glomerular Injury glomerular cyst Glomerular cyst 2.32E-02 LGMN 1 Pulmonary Hypertension heritable pulmonary artery hypertension New York Heart Association class II heritable pulmonary artery hypertension 2.32E-02 PTGIR 1 Pulmonary Hypertension primary pulmonary hypertension New York Heart Association class II primary pulmonary hypertension 2.32E-02 PTGIR 1 Pulmonary Hypertension heritable pulmonary artery hypertension New York Heart Association class III heritable pulmonary artery hypertension 2.32E-02 PTGIR 1 Pulmonary Hypertension heritable pulmonary artery hypertension New York Heart Association class IV heritable pulmonary artery hypertension 2.32E-02 PTGIR 1 Pulmonary Hypertension primary pulmonary hypertension New York Heart Association class IV primary pulmonary hypertension 2.32E-02 PTGIR 1 Pulmonary Hypertension pulmonary arterial hypertension with connective tissue disorder Pulmonary arterial hypertension with connective tissue disorder 2.32E-02 PTGIR 1 Pulmonary Hypertension chronic thromboembolic pulmonary hypertension Pulmonary hypertension WHO functional class III chronic thromboembolic pulmonary hypertension 2.32E-02 PTGIR 1 Pulmonary Hypertension chronic thromboembolic pulmonary hypertension Pulmonary hypertension WHO functional class IV chronic thromboembolic pulmonary hypertension 2.32E-02 PTGIR 1 Glomerular Injury size Size of glomerular crescent 2.32E-02 PLG 1 Liver Inflammation/Hepatitis susceptibility to hepatitis C virus Susceptibility to hepatitis C virus 2.32E-02 KRT8 1 Pulmonary Hypertension WHO functional class I pulmonary arterial hypertension WHO functional class I pulmonary arterial hypertension 2.32E-02 PTGIR 1 Cardiac Dilation, Cardiac Enlargement idiopathic dilated cardiomyopathy Idiopathic dilated cardiomyopathy 2.41E-02 PGK1,LITAF 2 Glomerular Injury, Renal Inflammation, Renal Nephritis lupus-like autoimmune nephritis Lupus-like autoimmune nephritis 3.08E-02 TRAF3IP2 1 Pulmonary Hypertension primary pulmonary hypertension New York Heart Association class III primary pulmonary hypertension 3.08E-02 PTGIR 1 Cardiac Arteriopathy, Cardiac Fibrosis perivascular fibrosis Perivascular fibrosis of coronary artery 3.08E-02 ANGPT2 1 Renal Proliferation proliferation Proliferation of kidney cells 3.32E-02 ANGPT2,FAT4,POU3F3 3 Liver Steatosis hepatic steatosis Hepatic steatosis 3.35E-02 1.471 1.377 KRT8,PNLIP,FASN,FGL1,CGAS,LRP6,DGAT1,PLIN2,CASP2 9 Cardiac Dysfunction, Cardiac Fibrosis left ventricular fibrosis Left ventricular fibrosis 3.52E-02 ANGPT2,PTGIR 2 Renal Dilation dilation Dilation of collecting tubule 3.83E-02 PRKCSH 1 Pulmonary Hypertension drug induced pulmonary arterial hypertension Drug induced pulmonary arterial hypertension 3.83E-02 PTGIR 1 Pulmonary Hypertension chronic thromboembolic pulmonary hypertension Inoperable chronic thromboembolic pulmonary hypertension 3.83E-02 PTGIR 1 Pulmonary Hypertension chronic thromboembolic pulmonary hypertension Persistent chronic thromboembolic pulmonary hypertension 3.83E-02 PTGIR 1 Pulmonary Hypertension chronic thromboembolic pulmonary hypertension Recurrent chronic thromboembolic pulmonary hypertension 3.83E-02 PTGIR 1 Liver Hyperplasia/Hyperproliferation liver cholangiocarcinoma Resectable liver cholangiocarcinoma 3.83E-02 RRM2 1 Pulmonary Hypertension toxin induced pulmonary arterial hypertension Toxin induced pulmonary arterial hypertension 3.83E-02 PTGIR 1 Increased Levels of ALT quantity Increased Levels of ALT 4.05E-02 ITGB3,PLG 2 Liver Inflammation/Hepatitis, Liver Steatosis steatohepatitis Steatohepatitis 4.54E-02 CGAS,LRP6,CASP2 3 Liver Adhesion adhesion Adhesion of hepatocytes 4.58E-02 KRT8 1 Liver Hyperplasia/Hyperproliferation liver cholangiocarcinoma Locally advanced liver cholangiocarcinoma 4.58E-02 RRM2 1 Renal Hypoplasia agenesis Agenesis of kidney 4.60E-02 LRP4,EMX2 2 Cardiac Dysfunction diastolic dysfunction Diastolic dysfunction 4.98E-02 ANGPT2,ACAA1 2 Renal Inflammation, Renal Nephritis nephritis Nephritis 5.21E-02 -1.182 -1.339 ANGPT2,TRAF3IP2,IFI44,TNFSF14,CGAS,SCARF1,CR1,B4GALT1 8 Kidney Failure failure Failure of kidney 5.22E-02 1.000 0.877 CHRNB3,AGA,ANGPT2,LGMN,CHRNA10,POU3F3 6 Increased Levels of ALT activation Increased activation of ALT 5.32E-02 PLG 1 Cardiac Enlargement enlargement Enlargement of heart 5.51E-02 FRRS1,TSG101,ANGPT2,TRAF3IP2,ABCA5,PPP1CA,FASN,PGK1,ITGB3,FLNC,LITAF,PTGIR 12 Increased Levels of ALT release Increased release of ALT 6.06E-02 ITGB3 1 Cardiac Dysfunction right ventricular dysfunction Right ventricular dysfunction 6.06E-02 PLG 1 Cardiac Dysfunction, Cardiac Enlargement hypertrophy Hypertrophy of left ventricle 6.21E-02 ANGPT2,ITGB3,PTGIR 3 Cardiac Arrythmia long-QT syndrome Long-QT syndrome 6.41E-02 RNF207,CALM1 (includes others) 2 Pulmonary Hypertension pulmonary hypertension Pulmonary Hypertension 6.62E-02 CHRNB3,CHRNA10,PLG,PTGIR 4 Liver Inflammation/Hepatitis, Liver Steatosis alcoholic steatohepatitis Alcoholic steatohepatitis 6.79E-02 CGAS 1 Hepatocellular carcinoma, Liver Hyperplasia/Hyperproliferation hepatitis B virus-related hepatocellular carcinoma Hepatitis B virus-related hepatocellular carcinoma 6.86E-02 PGK1,FASN,ACAA1 3 Cardiac Dilation, Cardiac Enlargement primary dilated cardiomyopathy Primary dilated cardiomyopathy 7.13E-02 PGK1,FLNC,LITAF 3 Cardiac Arrythmia syndromic arrhythmia Syndromic arrhythmia 7.41E-02 RNF207,CALM1 (includes others),FLNC 3 Renal Dilation dilation Dilation of kidney 7.51E-02 PRKCSH 1 Glomerular Injury urological disorder Urological disorder of renal glomerulus 7.51E-02 TRAF3IP2 1 Cardiac Dilation, Cardiac Enlargement dilated cardiomyopathy Dilated cardiomyopathy 8.05E-02 FRRS1,ABCA5,PPP1CA,PGK1,FASN,FLNC,LITAF 7 Cardiac Fibrosis interstitial fibrosis Interstitial fibrosis of heart 8.18E-02 ANGPT2,TRAF3IP2 2 Cardiac Arrythmia arrhythmia Arrhythmia 8.25E-02 RNF207,ANGPT2,CALM1 (includes others),PPP1CA,FLNC,SERINC2 6 Cardiac Arteriopathy coronary artery disease Coronary artery disease 8.47E-02 TSNARE1,ETNK1,ITGB3,LRP6,PTGIR 5 Renal Atrophy atrophy Atrophy of renal cortex 8.95E-02 LGMN 1 Cardiac Arrythmia, Congenital Heart Anomaly long QT syndrome 1 Long QT syndrome 1 8.95E-02 CALM1 (includes others) 1 Cardiac Dysfunction ventricular dysfunction Ventricular dysfunction 9.91E-02 LRP5,ANGPT2,ITGB3,PLG,PTGIR 5 Glomerular Injury, Renal Inflammation, Renal Nephritis glomerulonephritis Glomerulonephritis 1.03E-01 -1.342 -1.446 TRAF3IP2,IFI44,TNFSF14,SCARF1,CR1,B4GALT1 6 Cardiac Infarction acute ST-elevation myocardial infarction Acute ST-elevation myocardial infarction 1.04E-01 PLG 1 Cardiac Infarction myocardial infarction Recurrent myocardial infarction 1.04E-01 ITGB3 1 Cardiac Infarction susceptibility to myocardial infarction Susceptibility to myocardial infarction 1.04E-01 ITGB3 1 Renal Necrosis/Cell Death apoptosis Apoptosis of kidney cell lines 1.04E-01 Increased 2.236 2.306 BIRC2,LRP5,LRP6,CASP2,BIRC3 5 Liver Steatosis nonalcoholic fatty liver disease Nonalcoholic fatty liver disease 1.06E-01 FASN,DGAT1,PLIN2,CASP2 4 Cardiac Arrythmia, Tachycardia catecholaminergic polymorphic ventricular tachycardia type 1 Catecholaminergic polymorphic ventricular tachycardia type 1 1.11E-01 CALM1 (includes others) 1 Cardiac Damage damage Damage of myocardium 1.11E-01 ANGPT2 1 Glomerular Injury expansion Expansion of mesangial matrix 1.11E-01 B4GALT1 1 Cardiac Fibrosis fibrosis Fibrosis of heart 1.14E-01 -0.722 -0.781 ANGPT2,TRAF3IP2,PLG,PTGIR,WRN 5 Glomerular Injury, Renal Damage injury Injury of podocytes 1.17E-01 ANGPT2 1 Glomerular Injury glomerulosclerosis Glomerulosclerosis 1.18E-01 0.000 -0.086 AGA,ANGPT2,LGMN,B4GALT1 4 Renal Necrosis/Cell Death cell death Cell death of kidney cell lines 1.21E-01 Increased 2.400 2.479 BIRC2,TRPM2,LRP5,LRP6,CASP2,BIRC3 6 Cardiac Dysfunction, Cardiac Fibrosis interstitial fibrosis Interstitial fibrosis of left ventricle 1.31E-01 ANGPT2 1 Cardiac Infarction ST-elevation myocardial infarction ST-elevation myocardial infarction 1.31E-01 ITGB3,PLG 2 Heart Failure heart failure with preserved ejection fraction Heart failure with preserved ejection fraction 1.38E-01 PTGIR 1 Glomerular Injury, Renal Hyperplasia/Hyperproliferation hyperplasia Hyperplasia of mesangial cells 1.45E-01 TRAF3IP2 1 Cardiac Arrythmia inherited arrhythmia syndrome Inherited arrhythmia syndrome 1.50E-01 CALM1 (includes others),FLNC 2 Liver Necrosis/Cell Death apoptosis Apoptosis of hepatic stellate cells 1.58E-01 ITGB3 1 Hepatocellular carcinoma, Liver Hyperplasia/Hyperproliferation growth Growth of hepatocellular carcinoma 1.71E-01 RRM2 1 Cardiac Enlargement hypertrophy Hypertrophy of cardiomyocytes 1.75E-01 TSG101,ANGPT2,TRAF3IP2 3 Renal Hydronephrosis hydronephrosis Hydronephrosis 1.77E-01 AGA,LGMN 2 Glomerular Injury abnormal morphology Abnormal morphology of glomerular capillary 1.77E-01 TRAF3IP2 1 Glomerular Injury formation Formation of glomerular crescent 1.77E-01 PLG 1 Cardiac Infarction nonfatal myocardial infarction Nonfatal myocardial infarction 1.77E-01 ITGB3 1 Liver Hyperplasia/Hyperproliferation liver cholangiocarcinoma Unresectable liver cholangiocarcinoma 1.77E-01 RRM2 1 Liver Inflammation/Hepatitis alcoholic hepatitis Severe alcoholic hepatitis 1.84E-01 CGAS 1 Cardiac Dysfunction left ventricular dysfunction Left ventricular dysfunction 2.08E-01 LRP5,ANGPT2,ITGB3,PTGIR 4 Glomerular Injury abnormal morphology Abnormal morphology of mesangial matrix 2.09E-01 B4GALT1 1 Liver Steatosis macrovesicular hepatic steatosis Macrovesicular hepatic steatosis 2.09E-01 FGL1 1 Hepatocellular carcinoma, Liver Hyperplasia/Hyperproliferation hepatocellular carcinoma Primary hepatocellular carcinoma 2.09E-01 FASN 1 Decreased Levels of Potassium quantity Decreased Levels of Potassium 2.15E-01 POU3F3 1 Hepatocellular carcinoma, Liver Hyperplasia/Hyperproliferation metastatic hepatocellular carcinoma Metastatic hepatocellular carcinoma 2.21E-01 RRM2 1 Hepatocellular carcinoma, Liver Hyperplasia/Hyperproliferation recurrent hepatocellular carcinoma Recurrent hepatocellular carcinoma 2.21E-01 RRM2 1 Cardiac Enlargement enlargement Enlargement of ventricular myocytes 2.27E-01 ANGPT2 1 Liver Hemorrhaging bleeding Bleeding of liver 2.33E-01 KRT8 1 Cardiac Dysfunction calcification Calcification of aortic valve 2.33E-01 LRP5 1 Cardiac Dilation, Cardiac Enlargement dominant dilated cardiomyopathy Dominant dilated cardiomyopathy 2.39E-01 FLNC 1 Cardiac Arrythmia persistent atrial fibrillation Persistent atrial fibrillation 2.39E-01 PPP1CA 1 Cardiac Arrythmia, Tachycardia tachycardia Tachycardia 2.42E-01 ANGPT2,CALM1 (includes others) 2 Renal Damage reperfusion injury Reperfusion injury of kidney 2.45E-01 COLEC11 1 Cardiac Infarction non-ST elevation myocardial infarction Non-ST elevation myocardial infarction 2.57E-01 ITGB3 1 Cardiac Enlargement hypertrophy Hypertrophy of heart 2.60E-01 TSG101,ANGPT2,TRAF3IP2,FASN,ITGB3,PTGIR 6 Glomerular Injury, Renal Inflammation, Renal Nephritis systemic lupus erythematosus nephritis Systemic lupus erythematosus nephritis 2.63E-01 IFI44 1 Hepatocellular carcinoma, Liver Hyperplasia/Hyperproliferation development Development of hepatocellular carcinoma 2.68E-01 BIRC2,XPO7 2 Cardiac Dilation, Cardiac Enlargement familial primary dilated cardiomyopathy Familial primary dilated cardiomyopathy 2.68E-01 FLNC 1 Cardiac Infarction acute myocardial infarction Acute myocardial infarction 2.77E-01 ITGB3,PLG 2 Cardiac Dilation dilation Dilation of heart chamber 2.80E-01 ANGPT2 1 Cardiac Infarction myocardial infarction Myocardial infarction 2.85E-01 KRT8,ITGB3,CR1,PLG 4 Liver Hyperplasia/Hyperproliferation liver cholangiocarcinoma Metastatic liver cholangiocarcinoma 2.85E-01 RRM2 1 Liver Inflammation/Hepatitis infection Infection by Hepatitis C virus 2.91E-01 KRT8,CHRNA10 2 Cardiac Necrosis/Cell Death apoptosis Apoptosis of cardiomyocytes 3.04E-01 CALCRL,FASN,DGAT1 3 Cardiac Arrythmia hereditary Wolff-Parkinson-White syndrome Hereditary Wolff-Parkinson-White syndrome 3.24E-01 FLNC 1 Liver Proliferation proliferation Proliferation of liver cells 3.25E-01 FGL1,ITGB3,PLG 3 Cardiac Damage cardiotoxicity Cardiotoxicity 3.29E-01 ACAA1 1 Glomerular Injury, Renal Inflammation, Renal Nephritis proliferative glomerulonephritis Proliferative glomerulonephritis 3.44E-01 CR1 1 Bradycardia, Cardiac Arrythmia bradycardia Bradycardia 3.55E-01 ANGPT2 1 Renal Proliferation proliferation Proliferation of mesangial cells 3.55E-01 ANGPT2 1 Liver Damage damage Liver Damage 3.63E-01 KRT8,CR1,PLG 3 Cardiac Congestive Cardiac Failure, Heart Failure congestive heart failure Congestive heart failure 3.71E-01 BIRC2,BIRC3 2 Liver Damage hepatic injury Hepatic injury 3.71E-01 KRT8,CR1 2 Cardiac Stenosis stenosis Stenosis of aortic valve 3.74E-01 WRN 1 Liver Cholestasis progressive familial intrahepatic cholestasis type 1 Progressive familial intrahepatic cholestasis type 1 3.79E-01 SULT1A2 1 Liver Fibrosis, Liver Proliferation proliferation Proliferation of hepatic stellate cells 3.84E-01 ITGB3 1 Heart Failure failure Failure of heart 3.90E-01 BIRC2,KRT8,PTGIR,BIRC3 4 Glomerular Injury, Renal Necrosis/Cell Death necrosis Necrosis of renal glomerulus 4.08E-01 PLG 1 Liver Inflammation/Hepatitis, Liver Steatosis nonalcoholic steatohepatitis Nonalcoholic steatohepatitis 4.31E-01 CASP2 1 Liver Fibrosis activation Activation of hepatic stellate cells 4.35E-01 DGAT1 1 Renal Enlargement nephromegaly Nephromegaly 4.44E-01 PLG 1 Cardiac Arrythmia atrial fibrillation Atrial fibrillation 4.49E-01 PPP1CA,SERINC2 2 Liver Fibrosis fibrosis Fibrosis of liver 4.62E-01 KRT8,LRP6,PLG,SERINC2 4 Liver Proliferation proliferation Proliferation of hepatocytes 4.62E-01 FGL1,PLG 2 Renal Damage injury Injury of kidney 4.70E-01 ANGPT2,COLEC11 2 Liver Inflammation/Hepatitis chronic hepatitis C Chronic hepatitis C 4.90E-01 CHRNA10 1 Liver Hyperplasia/Hyperproliferation liver metastasis Liver metastasis 4.94E-01 L1CAM 1 Renal Necrosis/Cell Death cell viability Cell viability of kidney cell lines 1.00E00 CEBPD 1 Liver Cirrhosis, Liver Fibrosis cirrhosis Cirrhosis of liver 1.00E00 KRT8,SERINC2 2 Congenital Heart Anomaly congenital heart disease Congenital heart disease 1.00E00 CALM1 (includes others),ABCA3,PTK7 3 Cardiac Proliferation proliferation Proliferation of cardiomyocytes 1.00E00 CALCRL 1 Regulator Effects for My Projects->Mac - Oyster RNA-Seq->20220810_NOPP-gigas-ploidy-temp_pval_only 10:49 AM->desiccation_ploidy Consistency Score Node Total Regulator Total Regulators Target Total Target Molecules in Dataset Disease & Function Total Diseases & Functions Known Regulator-Disease/Function Relationships 1.768 12 2 HGF,HMOX1 8 ANGPT2,BIRC2,BIRC3,CASP2,ITGB3,L1CAM,LGMN,TNFSF14 2 Leukocyte migration,Necrosis of tumor 100% (4/4) Networks for My Projects->Mac - Oyster RNA-Seq->20220810_NOPP-gigas-ploidy-temp_pval_only 10:49 AM->desiccation_ploidy ID Analysis Molecules in Network Score Focus Molecules Top Diseases and Functions 1 desiccation_ploidy ACAA1,ADRM1,AIMP2,AOC1,ATL2,BIRC2,BIRC3,CLEC10A,CUBN,Ck2 alpha,DUT,ERK1/2,ETNK1,Fcna,GLB1,Growth hormone,Gsk3,HDL,IL12 (family),KIFC1,LITAF,MATR3,NUBP1,P2rx7,PNLIP,Pro-inflammatory Cytokine,RAB11A,RRP12,TNFSF14,TRIM2,TRIM3,TRPM2,TSG101,Tnf (family),calpain 52 26 Cellular Assembly and Organization, Cellular Function and Maintenance, Antimicrobial Response 2 desiccation_ploidy AGA,ANGPTL3,ANKRD50,ANOS1,Akt,Alp,BBX,DGAT1,EGLN,EMX2,FAT4,FUT6,Frizzled,H2AC21,ITGB3,L1CAM,LDL,LRP,LRP4,LRP5,LRP6,MGAT4C,NCAN,PDGF BB,PLG,PLIN2,PTK7,RRP36,SCARF2,Secretase gamma,TNR,TNXB,Tenascin,VLDL,c-Src 47 24 Cell-To-Cell Signaling and Interaction, Tissue Development, Cell-mediated Immune Response 3 desiccation_ploidy ADCY,ADGRG6,ALDH7A1,ANGPT2,B4GALT1,C1QTNF4,CALCRL,CEBPD,CELSR1,CG,CaMKII,Calmodulin,Creb,DPY19L3,FAM234B,G protein alphai,GNAO1,GSTM3,Gpcr,HCRTR2,HSD3B2,L3HYPDH,MEGF10,NFkB (complex),Nr1h,PDZD7,PLC,PTGIR,Pka,Pkc(s),SLC5A7,SNAP25,SOD3,TRAF3IP2,voltage-gated calcium channel 41 22 Developmental Disorder, Hereditary Disorder, Organismal Injury and Abnormalities 4 desiccation_ploidy Actin,Alpha catenin,Ap1,BCR (complex),C1QTNF3,CALM1 (includes others),CD3,Collagen type I (complex),Collagen(s),F Actin,Focal adhesion kinase,HSPA12B,Hdac,Histone h4,Hsp90,IL12 (complex),JINK1/2,Jnk,KMT5A,KRT8,MAPK4,MEGF6,MKX,MMRN1,NLGN2,PGK1,PRKCSH,REG1A,SLC16A7,SNX33,TCR,TRIM36,Tgf beta,caspase,p70 S6k 27 16 Developmental Disorder, Hereditary Disorder, Neurological Disease 5 desiccation_ploidy ABCA3,ADRB2,CHAC1,CTNNB1,DDB2,EMILIN2,FGL1,FIBCD1,HDHD5,HDL-cholesterol,IL20,Lgals6,MEGF11,MYOD1,NDUFS6,NIPSNAP3A,NSUN2,NTSR1,PLEKHA7,PRR12,PXDN,SLC52A1,SOD3,SPATS2L,SULT1A2,SUSD2,SYT12,TLE1,TLE3,TMEM161B,TMEM187,TNFSF8,WNT7A,beta-estradiol,miR-21-5p (and other miRNAs w/seed AGCUUAU) 23 14 Cancer, Organismal Injury and Abnormalities, Carbohydrate Metabolism 6 desiccation_ploidy ADAMTS16,ALT,AMPK,BCHE,C1q,CHRNA10,CR1,Cyclin A,ERK,FASN,FCGBP,FLNC,FSH,IFN Beta,IL1,IgG,Ige,Igm,Immunoglobulin,Insulin,Lh,Mapk,Mek,NF-Y,P38 MAPK,PI3K (family),PI3K p85,POLI,PTPRG,PTPRK,SCARF1,SRC (family),TPPP3,TRIM56,Vegf 21 13 Cancer, Gastrointestinal Disease, Organismal Injury and Abnormalities 7 desiccation_ploidy ABCA5,AFDN,BAMBI,C1QL1,CCDC13,CD44,CHRNB3,CHRNB4,COL14A1,COL4A2,CSF3,CSK,DYNLT5,ECSIT,EPCAM,FRRS1,IL6,ITIH6,LIMA1,MEF2D,MEOX2,PEPCK,PLAT,POU3F3,Prrt1,RBP4,RPS6,RSL24D1,SLC16A4,SOD3,SYCE2,TLE1,heparan sulfate,miR-21-5p (and other miRNAs w/seed AGCUUAU),tretinoin 21 13 Cardiovascular System Development and Function, Tissue Development, Cell-To-Cell Signaling and Interaction 8 desiccation_ploidy AFDN,ARHGEF2,ARL6IP4,ATP7A,BCL9,CACHD1,CALML3,CLU,CREBBP,CSRNP3,CWF19L2,DDO,EPHA4,FURIN,GPIHBP1,HMGB1,HNRNPM,HRAS,KLHL13,LRRC74A,MMRN2,PEX5,PGBD4,PLEC,PPP1CA,PTPRH,RFESD,SDHB,SORL1,TAFA2,TEDC2,TENM3,TRADD,VIRMA,VWDE 21 13 Cancer, Hematological Disease, Immunological Disease 9 desiccation_ploidy ADAM12,AFDN,AGT,ANGPT2,BBLN,COL4A2,CYTH3,Clathrin,DDX58,EDNRA,EDNRB,EPS8,GNAQ,HMGB1,MTNR1A,NFATC4,NUCB1,PKD1L2,PLAT,RABL2B,RASEF,RETN,SERINC2,SLC16A14,SRC,SSPOP,SVEP1,TCF25,TKFC,TRIP6,TSNARE1,ZMYM1,heparan sulfate,miR-21-5p (and other miRNAs w/seed AGCUUAU),thiobarbituric acid reactive substances 19 12 Molecular Transport, Protein Trafficking, Cardiac Enlargement 10 desiccation_ploidy ATXN2,CACFD1,CHST12,COL14A1,COLEC11,CSMD3,CYP,CYP39A1,Cyp2d22,DDX20,ERCC3,G6PC1,GGNBP2,HSPA5,MFSD1,NR3C1,PCSK9,PLOD2,POR,RAVER1,RETN,SPP1,Sod,THAP2,TLE3,TP53,TULP4,TYRP1,UBR1,WNT7A,WRN,ZMPSTE24,cholesterol,copper,fatty acid 17 11 Lipid Metabolism, Molecular Transport, Small Molecule Biochemistry 11 desiccation_ploidy AICAR,AKNA,ANKHD1/ANKHD1-EIF4EBP3,ARHGEF2,ASPG,ATP13A2,ATXN2,BGN,BSG,CD40LG,CLPB,CNOT2,COG5,EGFR,EPS8,FHL3,GOLM1,HMGB1,HSPA8,LONP1,MB21D2,MDK,NANOS1,PIF1,PPIL2,RIPK1,RNF207,SDHB,SORL1,TEDC2,THSD4,VPS25,XPO7,ZSWIM9,miR-21-5p (and other miRNAs w/seed AGCUUAU) 17 11 Cancer, Organismal Injury and Abnormalities, Tumor Morphology 12 desiccation_ploidy 26s Proteasome,AFDN,AICAR,ANK1,CASP2,CD209,CGAS,CTSA,DDB2,EDNRA,ELF1,FAM111A,H2BC21,HPSE,Histone h3,IFI44,IKK (complex),Interferon alpha,LGMN,PI3K (complex),PTK,RAS,RETN,RIPK1,RRM2,SPATS2L,Sod,TENT4A,TMPRSS6,TYR,Ubiquitin,cytokine,hemoglobin,miR-21-5p (and other miRNAs w/seed AGCUUAU),transcription factor 15 10 Dermatological Diseases and Conditions, Inflammatory Disease, Inflammatory Response 13 desiccation_ploidy HARBI1,NAIF1 2 1 Cancer, Neurological Disease, Organismal Injury and Abnormalities 14 desiccation_ploidy PAX6,TTC24 2 1 Cell Cycle, Cell Death and Survival, Cell Morphology 15 desiccation_ploidy TRIM54,TSPEAR 2 1 Auditory Disease, Dental Disease, Dermatological Diseases and Conditions My Lists for My Projects->Mac - Oyster RNA-Seq->20220810_NOPP-gigas-ploidy-temp_pval_only 10:49 AM->desiccation_ploidy My Lists -log(p-value) Molecules DevBloodVesselSelectionGraph 1.19E00 3.77E-02 ANGPT2,ANGPTL3 SMdevelopfunctionSM 6.67E-01 3.23E-02 FLNC MuscleCellProliferation 6.64E-01 1.79E-02 ANGPT2,CEBPD Vasculogenesis 4.91E-01 1.17E-02 ANGPT2,ANGPTL3,L1CAM MuscleDevelopment 0E00 7.35E-03 FLNC MyogenesisMuscleDevelopment 0E00 7.35E-03 FLNC Tox Lists for My Projects->Mac - Oyster RNA-Seq->20220810_NOPP-gigas-ploidy-temp_pval_only 10:49 AM->desiccation_ploidy Ingenuity Toxicity Lists -log(p-value) Molecules Increases Renal Nephritis 3.82E00 7.69E-02 ANGPT2,TRAF3IP2,TNFSF14,CGAS,CR1 Liver Necrosis/Cell Death 2.84E00 2.64E-02 BIRC2,KRT8,AGA,TNFSF14,FASN,ITGB3,CR1,PLG,BIRC3 Anti-Apoptosis 1.59E00 6.25E-02 BIRC2,BIRC3 Increases Glomerular Injury 1.4E00 2.44E-02 ANGPT2,TRAF3IP2,TNFSF14,CR1 Pro-Apoptosis 1.37E00 4.76E-02 TNFSF14,CASP2 LPS/IL-1 Mediated Inhibition of RXR Function 1.29E00 1.94E-02 SOD3,ALDH7A1,SULT1A2,GSTM3,Cyp2d22 Decreases Permeability Transition of Mitochondria and Mitochondrial Membrane 1.27E00 1.43E-01 KRT8 Xenobiotic Metabolism Signaling 1.24E00 1.7E-02 SOD3,ALDH7A1,SULT1A2,GSTM3,BCHE,Cyp2d22 Increases Liver Steatosis 1.21E00 2.59E-02 DGAT1,PLIN2,CASP2 Oxidative Stress 1.14E00 3.51E-02 SOD3,GSTM3 Genes Upregulated in Response to Proteinuria-induced Oxidative Stress in Renal Proximal Tubule Cells (Human) 1.12E00 1E-01 SOD3 Cardiac Fibrosis 9.95E-01 1.58E-02 ANGPT2,TRAF3IP2,PTGIR,PLG,WRN Cytochrome P450 Panel - Substrate is a Sterol (Human) 9.85E-01 7.14E-02 CYP39A1 Cytochrome P450 Panel - Substrate is a Sterol (Mouse) 9.85E-01 7.14E-02 CYP39A1 Cytochrome P450 Panel - Substrate is a Sterol (Rat) 9.85E-01 7.14E-02 CYP39A1 Increases Liver Hyperplasia/Hyperproliferation 9.57E-01 2.01E-02 BIRC2,RRM2,L1CAM Increases Cardiac Dilation 9.05E-01 5.88E-02 ANGPT2 Aryl Hydrocarbon Receptor Signaling 8.83E-01 1.86E-02 ALDH7A1,GSTM3,FASN Increases Depolarization of Mitochondria and Mitochondrial Membrane 8.82E-01 5.56E-02 PLG Long-term Renal Injury Anti-oxidative Response Panel (Rat) 8.82E-01 5.56E-02 SOD3 Renal Necrosis/Cell Death 8.73E-01 1.23E-02 BIRC2,TRPM2,LRP5,CEBPD,LRP6,CASP2,PLG,BIRC3 TR/RXR Activation 8.57E-01 2.38E-02 SYT12,FASN Increases Bradycardia 8.4E-01 5E-02 ANGPT2 Glutathione Depletion - Phase II Reactions 8.4E-01 5E-02 GSTM3 Increases Renal Proliferation 8.28E-01 1.75E-02 ANGPT2,FAT4,POU3F3 Nongenotoxic Hepatocarcinogenicity Biomarker Panel 8.02E-01 4.55E-02 LITAF Cytochrome P450 Panel - Substrate is a Xenobiotic (Mouse) 7.67E-01 4.17E-02 Cyp2d22 Cardiac Hypertrophy 7.59E-01 1.32E-02 TSG101,ANGPT2,TRAF3IP2,ITGB3,PTGIR Cytochrome P450 Panel - Substrate is a Xenobiotic (Rat) 7.51E-01 4E-02 Cyp2d22 Increases Liver Hepatitis 7.38E-01 2E-02 TNFSF14,CASP2 Renal Proximal Tubule Toxicity Biomarker Panel (Rat) 7.21E-01 3.7E-02 SLC16A7 Increases Renal Damage 6.88E-01 1.85E-02 ANGPT2,COLEC11 Persistent Renal Ischemia-Reperfusion Injury (Mouse) 6.8E-01 3.33E-02 AOC1 Fatty Acid Metabolism 6.36E-01 1.71E-02 ALDH7A1,ACAA1 Decreases Depolarization of Mitochondria and Mitochondrial Membrane 6.1E-01 2.78E-02 BIRC3 NRF2-mediated Oxidative Stress Response 5.45E-01 1.26E-02 SOD3,GSTM3,Cyp2d22 Decreases Transmembrane Potential of Mitochondria and Mitochondrial Membrane 5.35E-01 1.45E-02 AGA,CASP2 Liver Proliferation 4.4E-01 1.09E-02 FGL1,ITGB3,PLG Acute Renal Failure Panel (Rat) 4.15E-01 1.61E-02 SLC16A7 PPARα/RXRα Activation 3.48E-01 1.03E-02 FASN,ACAA1 VDR/RXR Activation 3.4E-01 1.28E-02 LRP5 Cardiac Necrosis/Cell Death 3.31E-01 9.2E-03 CALCRL,FASN,DGAT1 Increases Cardiac Dysfunction 3.17E-01 1.19E-02 ANGPT2 Mechanism of Gene Regulation by Peroxisome Proliferators via PPARα 2.8E-01 1.05E-02 DUT p53 Signaling 2.68E-01 1.01E-02 FASN LXR/RXR Activation 2.09E-01 8.13E-03 FASN FXR/RXR Activation 2.03E-01 7.94E-03 FASN Hepatic Fibrosis 0E00 5.92E-03 KRT8,SERINC2 Hepatic Cholestasis 0E00 5.24E-03 TNFSF14 My Pathways for My Projects->Mac - Oyster RNA-Seq->20220810_NOPP-gigas-ploidy-temp_pval_only 10:49 AM->desiccation_ploidy My Pathways -log(p-value) Molecules ANGPT 1.51E00 2.5E-01 ANGPT2 BloodVesselDevelop 1.19E00 3.77E-02 ANGPT2,ANGPTL3 Analysis Ready Molecules for My Projects->Mac - Oyster RNA-Seq->20220810_NOPP-gigas-ploidy-temp_pval_only 10:49 AM->desiccation_ploidy ID Symbol Expr p-value Expr Log Ratio ENSDART00000186891.1 ABCA3 0.04062572 -1.996776E-5 ENSDART00000155563.2 ABCA5 0.02228161 -0.4329912 ENSDART00000007997.8 ACAA1 0.00102570886630529 1.31545309251839 ENSDART00000092657.6 ADAMTS16 0.00186745671138182 0.713986659246752 C6KFA3.1 ADGRG6 0.03649877 -4.340889E-7 ENSDART00000192684.1 ADRM1 0.01714386 -0.5062009 ENST00000506853.5 AGA 0.01671173 -0.9166765 Q9WVM7.1 AIMP2 0.0481457 -0.2699452 ENST00000312033.3 AKNA 0.02497336 -0.3894717 ENSDART00000122540.3 ALDH7A1 0.0436937855025805 0.59165186719321 A0A8J8.1 ANGPT2 0.01553591 -0.76826 ENSDART00000140004.3 ANGPTL3 0.0144643758616307 1.00175472530285 P16157.3 ANK1 0.02432605 -1.069892 Q9ULJ7.4 ANKRD50 0.001867457 -1.213825 P33005.2 ANOS1 0.001425682 -1.395787 ENSDART00000087422.5 AOC1 0.0136665643908854 0.999855134907926 ENSDART00000180365.1 ARL6IP4 0.04596991 -0.4822666 ENSDART00000184167.1 ASPG 0.0240313 -1.84102E-5 ENSDART00000187004.1 ATL2 0.0329406 -6.459028E-6 ENSDART00000168437.2 B4GALT1 0.00219834523602915 1.05500543233137 Q2NKS9.1 BBLN 0.0157276 -0.3970186 ENSDART00000177781.2 BBX 0.0229952104756386 5.78063198407336E-6 ENST00000482958.1 BCHE 0.04245941 -1.035476E-5 Q13490.2 BIRC2 0.01285246 -2.114853E-5 Q13489.2 BIRC3 0.01817626 -1.20384 O75973.1 C1QL1 0.0175692422233871 1.12184150910084 Q9BXJ4.1 C1QTNF3 6.14203994940491E-7 1.69834363036276 Q8R066.1 C1QTNF4 0.0101218245203236 0.936237436338234 Q9UGQ2.1 CACFD1 0.0160682374645808 1.17989096190846 Q5VU97.2 CACHD1 0.01534419 -0.600549 Q8WN93.1 CALCRL 0.03881592 -1.523847 ENSDART00000014868.9 CALM1 (includes others) 0.0224306 -0.6991666 Q5U206.1 CALML3 0.04625035 -0.9640373 Q98943.2 CASP2 0.0200414882945965 2.36358105546535 ENSDART00000148553.2 CCDC13 1.51973E-4 -1.891755 Q91ZW7.1 CD209 1.668559E-5 -3.981812 Q03484.1 CEBPD 0.04572374 -8.425666E-6 O35161.3 CELSR1 0.00665936253792807 0.609947065041133 Q8C6L5.1 CGAS 0.0445647932420986 1.12511726280376 Q5SPB6.1 CHAC1 0.002796449 -8.090953E-6 Q9I8C7.1 CHRNA10 0.00213213804548213 3.52955767218658 P43679.2 CHRNB3 2.45337231764307E-4 4.01641098488611 Q8IUN9.1 CLEC10A 0.03782886 -5.835702E-6 ENSDART00000128224.3 CLPB 0.0497281424837227 0.55984950017047 Q5U3G1.1 COLEC11 0.0382753 -7.880412E-6 P17927.3 CR1 0.0364987738701911 1.57174594894767 Q80T79.3 CSMD3 0.03097252 -9.831671E-6 ENSDART00000110069.4 CSRNP3 0.00102570886630529 3.98210570614981 O70244.2 CUBN 2.19845820421118E-4 3.81676924093633 Q64680.1 Cyp2d22 0.04095322 -1.976773E-5 ENSDART00000005764.4 CYP39A1 0.0496943440043486 0.737651796980133 Q99489.1 DDO 0.008879535167508 0.57623017495891 ENSDART00000175701.2 DDX20 7.19053157295868E-4 0.90177723702818 ENSDART00000158946.2 DGAT1 0.0341497890269558 0.692837896341666 ENSDART00000114669.5 DPY19L3 0.02736366 -0.7936115 ENSDART00000179072.2 DUT 0.04062572 -3.755391E-6 ENSDART00000189390.1 DYNLT5 0.03850146 -1.708543E-5 Q8K482.1 EMILIN2 0.0293011143075934 1.27111575799862 ENSDART00000058036.6 EMX2 0.002609576 -0.992825 ENSDART00000017726.8 ETNK1 0.0234237123785838 0.688712278058422 Q96PZ2.2 FAM111A 0.002609576 -0.7736375 Q8BYI8.1 FAM234B 0.0157276 -0.8801928 P12276.5 FASN 0.001675883 -2.640583 Q6V0I7.2 FAT4 0.0465641796474727 0.672074519499892 Q9Y6R7.3 FCGBP 0.00928747486869907 1.07059161224899 Q9WTS8.2 Fcna 8.53376495818334E-4 0.98532730007205 ENST00000523097.1 FGL1 1.87638652146331E-7 1.78346923595338 ENSDART00000192530.1 FIBCD1 0.0383707042481294 0.433873699610309 ENST00000346177.6 FLNC 0.0308915027487673 0.722546989051099 Q8MSU3.1 FRRS1 1.04900724136644E-4 2.41564004469767 Q9VUL9.2 FUT6 0.01103847 -5.920757E-6 ENSDART00000113627.3 GGNBP2 0.03100816 -2.877717E-5 ENSDART00000124682.4 GLB1 0.01323699 -4.337211E-6 Q80WQ9.1 Gm15583/Zbed4 0.00820094398563498 1.74263041895656 ENST00000640893.1 GNAO1 0.0329406 -1.652024E-5 ENSDART00000049793.8 GSTM3 0.0134145439993333 0.802330724895932 ENSDART00000190100.1 H2AC21 1.63300642837534E-4 4.05156491396159 ENSDART00000152766.2 H2BC21 0.007785817 -4.808317 Q6AZB8.1 HARBI1 2.847416E-4 -1.23884 O43614.2 HCRTR2 0.007694743 -1.227869E-5 Q9BXW7.1 HDHD5 0.01219874 -1.386663 Q9BVR0.2 HERC2P3 0.003645606 -0.6644605 Q9D0E1.3 HNRNPM 0.02640962 -1.024386E-5 P26439.2 HSD3B2 0.0316525974574628 0.909750156075487 Q96MM6.2 HSPA12B 0.0348226735690674 0.561412490109514 P27473.1 IFI44 0.00237523613612389 1.42208314012481 Q8R2H2.1 ITGB3 0.001855495 -2.277017 ENSDART00000142851.3 ITIH6 0.04126825 -0.3529358 ENST00000428849.7 KIFC1 0.0100806197908147 1.1990211960074 Q2YDJ8.1 KMT5A 0.02444851 -0.5661699 ENSDART00000081223.6 KRT8 0.04126825 -4.538521E-6 Q05695.3 L1CAM 0.0138878 -8.372193E-6 ENSDART00000172158.2 L3HYPDH 0.0066726946416451 1.13467365334778 O54891.1 Lgals6 0.02900209 -0.3496678 ENSDART00000189978.1 LGMN 0.03782886 -1.895726E-5 P0C0T0.1 LITAF 0.03544977 -2.132525 Q9QYP1.2 LRP4 0.003203968 -0.8486406 Q91VN0.3 LRP5 0.0166098750705676 2.92474486493008 O75581.2 LRP6 3.3341369277301E-6 1.61399452527233 Q0VAA2.2 LRRC74A 0.04249196 -7.1387E-6 ENST00000587823.1 MAPK4 0.03580868 5.703547E-7 Q8K310.1 MATR3 0.0263111806379021 0.349313127897625 Q8C525.1 MB21D2 0.0398525062121007 0.973102038367048 Q6DIB5.1 MEGF10 0.006387929 -6.920933E-6 Q80T91.3 MEGF11 0.00219834523602915 0.898709022792725 O75095.4 MEGF6 0.00928637364041499 1.63336977671472 Q9H3U5.2 MFSD1 0.04092921 -1.636806E-5 Q6ITT3.1 MGAT4C 0.0425674536461201 0.315946488628706 ENSDART00000185093.1 MKX 0.00322293976996634 0.513584929519741 B2RPV6.2 MMRN1 0.01356293 -0.4721066 Q9H8L6.2 MMRN2 0.03502718 -1.04204E-6 Q80WY3.2 NANOS1 1.567749E-4 -9.709863E-7 Q5IS41.1 NCAN 0.01290914 -1.458202 ENSDART00000125284.4 NLGN2 0.0253359930531277 0.826119742290026 ENSDART00000155396.3 NUBP1 0.01978607 -1.832211E-5 Q64663.1 P2rx7 0.00276317126832584 0.912641934112815 E9Q9W7.2 PDZD7 0.01817626 -0.6773344 Q96DM1.3 PGBD4 0.03206058 -4.81391E-6 ENSDART00000076333.6 PGK1 0.0175692422233871 0.541280317143484 Q7ZV90.1 PIF1 0.0290020924104254 1.35185800883959 Q7TN88.1 PKD1L2 0.03094881 -0.6941127 ENSDART00000045816.7 PLG 0.0288065477653741 1.10124370347507 Q4PLW0.1 PLIN2 1.5677493245624E-4 0.943260430549795 Q6P8U6.1 PNLIP 0.002758364 -0.8947202 ENSDART00000041371.6 POLI 0.04050065 -0.8648336 P79745.1 POU3F3 0.03649877 -8.510994E-6 ENSDART00000092906.6 PPP1CA 0.01606824 -0.6828542 O08795.1 PRKCSH 0.0329406 -7.483436E-6 O35449.1 Prrt1 0.0262112554692272 0.903448805846969 ENST00000440800.4 PRSS29P 0.04529485 -0.4660049 P43252.1 PTGIR 0.00297994084861773 0.783549727239732 Q91048.1 PTK7 0.0476806049355126 0.942516246586573 Q05909.1 PTPRG 0.00140266452627586 0.650554356247115 P35822.1 PTPRK 0.03097252 -1.146409E-5 ENST00000261890.7 RAB11A 0.04662668 -1.136734 ENSDART00000185010.1 RABL2B 0.02848552 -0.6398179 ENSDART00000182117.1 RASEF 0.02135227 -0.5826803 P10758.1 REG1A 0.030006798475753 0.937310709828231 ENST00000458310.1 RFESD 0.0455146 -1.261244E-5 A0JNG4.1 RNF207 0.01959381 -7.10888E-6 ENSDART00000165841.2 RRM2 0.02104853 -3.397652 ENSDART00000034829.9 RRP12 0.0144643758616307 0.61415931887867 Q3UFY0.1 RRP36 5.737211E-4 -0.4635131 ENSDART00000104717.4 RSL24D1 0.009465019 -0.5590914 Q5ND28.1 SCARF1 0.0160682374645808 0.976942038641162 Q96GP6.5 SCARF2 0.03850146 -0.4807329 ENSDART00000136546.2 SERINC2 0.009894151 -0.5592533 Q8K1C7.1 SLC16A14 0.0240096277699281 0.681896920502843 Q8R0M8.1 SLC16A4 0.01732727 -1.069484E-5 O60669.2 SLC16A7 0.01671173 -3.201166E-6 ENST00000264047.3 SLC5A7 0.02301744 -9.414127E-6 ENSDART00000153064.3 SNAP25 0.01817626 -0.2471978 ENST00000569152.1 SNX33 0.0425674536461201 0.396776364810875 O09164.1 SOD3 5.27770023591716E-7 1.41412330615067 Q2PC93.1 SSPOP 0.01323699 -0.5225929 P50226.2 SULT1A2 0.0425674536461201 0.523148571151404 ENST00000463101.1 SUSD2 0.02872609 -1.304978 A2AVA0.1 SVEP1 0.00587008608787321 1.07206775682843 Q6PIF2.2 SYCE2 0.0273636630740629 1.66463804398863 ENSDART00000170569.3 SYT12 0.0359282697500626 0.70138797960815 P0DMR5.1 Tdpoz3 (includes others) 0.02900209 -2.786637E-5 Q9P273.3 TENM3 1.59605882551701E-4 1.89409434820946 Q9H0W7.1 THAP2 5.1986410861935E-4 2.50418412828821 Q3UTY6.2 THSD4 0.009894151 -0.748501 ENSDART00000089333.5 TKFC 0.0208552 -1.206382 Q8C2L6.1 TMEM161B 0.0183518 -0.6952282 Q14656.1 TMEM187 0.019292259359974 0.782317284832149 ENST00000676104.1 TMPRSS6 0.0167117255351923 0.877518208230909 O43557.2 TNFSF14 0.0208552 -1.321105 ENSDART00000179804.1 TNR 0.0101218245203236 0.844720706178764 P22105.5 TNXB 0.0200174074952397 1.63428328906298 ENSDART00000178732.2 TPPP3 0.04833492 -6.213064E-7 Q8N7N6.1 TRAF3IP2 0.0286304079618958 0.537575721267234 Q9ESN6.1 TRIM2 0.003974946 -0.8807078 Q9R1R2.1 TRIM3 0.0236685694005142 0.591029786475486 Q9NQ86.2 TRIM36 0.0392931388696563 0.843500459760757 Q9BRZ2.3 TRIM56 0.01673081 -6.007796E-6 E9PTA2.3 TRPM2 0.04879877 -1.012123 Q99816.2 TSG101 0.01290914 -0.3571762 Q96NA8.2 TSNARE1 0.04529485 -7.333778E-6 Q8WU66.2 TSPEAR 0.0132369858431587 1.62088211534122 A2A3L6.1 TTC24 0.03572192 -0.2906123 ENSDART00000091818.6 TULP4 0.0308915 -1.764243E-5 ENSDART00000152433.3 VPS25 0.004932148 -1.190456 Q8N2E2.4 VWDE 0.0290020924104254 0.331253646161755 ENST00000444248.1 WASF4P 0.02736366 -0.5236822 Q14191.2 WRN 0.00680076084738289 1.37958962003818 ENSDART00000027612.7 XPO7 0.014230710594407 0.74311180765674 Q5SVZ6.1 ZMYM1 0.0439240546614437 2.23704837396646 Q6DI92.2 ZSWIM9 0.0382753 -3.237639E-6