knitr BiocGenerics S4Vectors IRanges GenomeInfoDb GenomicRanges matrixStats MatrixGenerics Biobase SummarizedExperiment DESeq2 limma edgeR BiasedUrn geneLenDataBase goseq dplyr AnnotationDbi GenomicFeatures data.table MASS calibrate affycoretools vsn tidybulk ggplot2 cowplot pheatmap gplots RColorBrewer ggrepel EnhancedVolcano pcaExplorer readxl apeglm ashr tibble plotly proto gsubfn RSQLite sqldf PCAtools ggpubr beepr genefilter circlize scales tidyverse tidyr readr purrr stringr forcats lubridate