Package: methylKit Type: Package Title: DNA methylation analysis from high-throughput bisulfite sequencing results Version: 1.24.0 Authors@R: c(person("Altuna", "Akalin", role = c("aut", "cre"), email = "aakalin@gmail.com"), person("Matthias","Kormaksson", role = "aut"), person("Sheng","Li", role = "aut"), person("Arsene", "Wabo", role = "ctb"), person("Adrian", "Bierling", role= "aut"), person("Alexander","Gosdschan", role="aut"), person("Katarzyna","Wreczycka", role="ctb")) Author: Altuna Akalin [aut, cre], Matthias Kormaksson [aut], Sheng Li [aut], Arsene Wabo [ctb], Adrian Bierling [aut], Alexander Gosdschan [aut] Maintainer: Altuna Akalin , Alexander Gosdschan Description: methylKit is an R package for DNA methylation analysis and annotation from high-throughput bisulfite sequencing. The package is designed to deal with sequencing data from RRBS and its variants, but also target-capture methods and whole genome bisulfite sequencing. It also has functions to analyze base-pair resolution 5hmC data from experimental protocols such as oxBS-Seq and TAB-Seq. Methylation calling can be performed directly from Bismark aligned BAM files. License: Artistic-2.0 URL: http://code.google.com/p/methylkit/ LazyLoad: yes NeedsCompilation: yes LinkingTo: Rcpp, Rhtslib (>= 1.13.1), zlibbioc SystemRequirements: GNU make biocViews: DNAMethylation, Sequencing, MethylSeq Depends: R (>= 3.5.0), GenomicRanges (>= 1.18.1), methods Imports: IRanges, data.table (>= 1.9.6), parallel, S4Vectors (>= 0.13.13), GenomeInfoDb, KernSmooth, qvalue, emdbook, Rsamtools, gtools, fastseg, rtracklayer, mclust, mgcv, Rcpp, R.utils, limma, grDevices, graphics, stats, utils Suggests: testthat (>= 2.1.0), knitr, rmarkdown, genomation, BiocManager VignetteBuilder: knitr Collate: 'methylKit.R' 'backbone.R' 'diffMeth.R' 'clusterSamples.R' 'regionalize.R' 'processBismarkAln.R' 'RcppExports.R' 'document_data.R' 'bedgraph.R' 'reorganize.R' 'percMethylation.R' 'normalizeCoverage.R' 'pool.R' 'adjustMethylC.R' 'updateMethObject.R' 'batchControl.R' 'dataSim.R' 'methylDBClasses.R' 'methylDBFunctions.R' 'tabix.functions.R' 'methSeg.R' 'diffMethDSS.R' 'deprecated_defunct.R' 'onUnload.R' RoxygenNote: 7.1.1 git_url: https://git.bioconductor.org/packages/methylKit git_branch: RELEASE_3_16 git_last_commit: 9870e27 git_last_commit_date: 2022-11-01 Date/Publication: 2022-11-01 Packaged: 2022-11-01 22:00:59 UTC; biocbuild Built: R 4.2.3; x86_64-pc-linux-gnu; 2025-04-22 23:10:53 UTC; unix