# go_term

go_id: GO:0030788
term: precorrin-2 C20-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-2 = S-adenosyl-L-homocysteine + H(+) + precorrin-3A.


go_id: GO:0030789
term: precorrin-3B C17-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + precorrin-3B = S-adenosyl-L-homocysteine + precorrin 4.


go_id: GO:0030790
term: chlorophenol O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + trichlorophenol = S-adenosyl-L-homocysteine + trichloroanisole.


go_id: GO:0030791
term: arsenite methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + arsenite = S-adenosyl-L-homocysteine + methylarsonate.


go_id: GO:0030792
term: methylarsonite methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + methylarsonite = S-adenosyl-L-homocysteine + dimethylarsinate.


go_id: GO:0030793
term: 3'-demethylstaurosporine O-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 3'-demethylstaurosporine + S-adenosyl-L-methionine = S-adenosyl-L-homocysteine + H(+) + staurosporine.


go_id: GO:0030794
term: (S)-coclaurine-N-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + (S)-coclaurine = S-adenosyl-L-homocysteine + (S)-N-methylcoclaurine.


go_id: GO:0030795
term: methyl jasmonate methylesterase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + a jasmonate = S-adenosyl-L-homocysteine + a methyljasmonate.


go_id: GO:0030796
term: cycloartenol 24-C-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + cycloartenol = (24R)-24-methylcycloart-25-en-3beta-ol + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030797
term: 24-methylenesterol C-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: 24-methylidenelophenol + S-adenosyl-L-methionine(1+) = (Z)-24-ethylidenelophenol + S-adenosyl-L-homocysteine + H(+).


go_id: GO:0030798
term: trans-aconitate 2-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine.


go_id: GO:0030805
term: regulation of cyclic nucleotide catabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of cyclic nucleotides.


go_id: GO:0030808
term: regulation of nucleotide biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.


go_id: GO:0030809
term: negative regulation of nucleotide biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.


go_id: GO:0030810
term: positive regulation of nucleotide biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of nucleotides.


go_id: GO:0030811
term: regulation of nucleotide catabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides.


go_id: GO:0030812
term: negative regulation of nucleotide catabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides.


go_id: GO:0030813
term: positive regulation of nucleotide catabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of nucleotides.


go_id: GO:0030833
term: regulation of actin filament polymerization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the assembly of actin filaments by the addition of actin monomers to a filament.


go_id: GO:0030834
term: regulation of actin filament depolymerization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the disassembly of actin filaments by the removal of actin monomers from a filament.


go_id: GO:0030835
term: negative regulation of actin filament depolymerization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of actin depolymerization.


go_id: GO:0030839
term: regulation of intermediate filament polymerization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the assembly of intermediate filaments by the addition of monomers to a filament.


go_id: GO:0030840
term: negative regulation of intermediate filament polymerization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament polymerization.


go_id: GO:0030841
term: positive regulation of intermediate filament polymerization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of intermediate filament polymerization.


go_id: GO:0030842
term: regulation of intermediate filament depolymerization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the disassembly of intermediate filaments by the removal of monomers from a filament.


go_id: GO:0030843
term: negative regulation of intermediate filament depolymerization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of intermediate filament depolymerization.


go_id: GO:0030844
term: positive regulation of intermediate filament depolymerization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of intermediate filament depolymerization.


go_id: GO:0030845
term: phospholipase C-inhibiting G protein-coupled receptor signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway which proceeds with inhibition of phospholipase C (PLC) activity and a subsequent decrease in the levels of cellular inositol trisphosphate (IP3) and diacylglycerol (DAG).


go_id: GO:0030846
term: termination of RNA polymerase II transcription, poly(A)-coupled
ontology: BP
definition:
An RNA polymerase II transcription termination process in which cleavage and polyadenylylation of the mRNA 3' end are coupled to transcription termination.


go_id: GO:0030847
term: termination of RNA polymerase II transcription, exosome-dependent
ontology: BP
definition:
The process in which transcription of nonpolyadenylated RNA polymerase II transcripts is terminated; coupled to the maturation of the RNA 3'-end.


go_id: GO:0030850
term: prostate gland development
ontology: BP
definition:
The process whose specific outcome is the progression of the prostate gland over time, from its formation to the mature structure. The prostate gland is a partly muscular, partly glandular body that is situated near the base of the mammalian male urethra and secretes an alkaline viscid fluid which is a major constituent of the ejaculatory fluid.


go_id: GO:0030851
term: granulocyte differentiation
ontology: BP
definition:
The process in which a myeloid precursor cell acquires the specialized features of a granulocyte. Granulocytes are a class of leukocytes characterized by the presence of granules in their cytoplasm. These cells are active in allergic immune reactions such as arthritic inflammation and rashes. This class includes basophils, eosinophils and neutrophils.


go_id: GO:0030853
term: negative regulation of granulocyte differentiation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of granulocyte differentiation.


go_id: GO:0030854
term: positive regulation of granulocyte differentiation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of granulocyte differentiation.


go_id: GO:0030855
term: epithelial cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of an epithelial cell, any of the cells making up an epithelium.


go_id: GO:0030857
term: negative regulation of epithelial cell differentiation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of epithelial cell differentiation.


go_id: GO:0030858
term: positive regulation of epithelial cell differentiation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of epithelial cell differentiation.


go_id: GO:0030859
term: polarized epithelial cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a polarized epithelial cell. The polarized epithelial cell can be any of the cells within an epithelium where the epithelial sheet is oriented with respect to the planar axis.


go_id: GO:0030860
term: regulation of polarized epithelial cell differentiation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of polarized epithelial cell differentiation.


go_id: GO:0030861
term: negative regulation of polarized epithelial cell differentiation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of polarized epithelial cell differentiation.


go_id: GO:0030862
term: positive regulation of polarized epithelial cell differentiation
ontology: BP
definition:
Any process that activates or increases the rate or extent of polarized epithelial cell differentiation.


go_id: GO:0030864
term: cortical actin cytoskeleton
ontology: CC
definition:
The portion of the actin cytoskeleton, comprising filamentous actin and associated proteins, that lies just beneath the plasma membrane.


go_id: GO:0030865
term: cortical cytoskeleton organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.


go_id: GO:0030866
term: cortical actin cytoskeleton organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of actin-based cytoskeletal structures in the cell cortex, i.e. just beneath the plasma membrane.


go_id: GO:0030869
term: RENT complex
ontology: CC
definition:
A protein complex that mediates transcriptional silencing at the rDNA locus (the name derives from regulator of nucleolar silencing and telophase). In Saccharomyces the complex contains Net1p, Sir2p, Cdc14p, and at least one more subunit.


go_id: GO:0030870
term: Mre11 complex
ontology: CC
definition:
Trimeric protein complex that possesses endonuclease activity; involved in meiotic recombination, DNA repair and checkpoint signaling. In Saccharomyces cerevisiae, the complex comprises Mre11p, Rad50p, and Xrs2p; complexes identified in other species generally contain proteins orthologous to the Saccharomyces cerevisiae proteins.


go_id: GO:0030874
term: nucleolar chromatin
ontology: CC
definition:
The portion of nuclear chromatin associated with the nucleolus; includes the DNA encoding the ribosomal RNA.


go_id: GO:0030875
term: rDNA protrusion
ontology: CC
definition:
Any of the tandem arrays of rDNA localized at the periphery of the nucleus and protruding into the nucleolus, and associated proteins. May be visible as a single or double spot by DAPI staining.


go_id: GO:0030876
term: interleukin-20 receptor complex
ontology: CC
definition:
A protein complex composed of an alpha and a beta receptor subunit and an interleukin ligand. In human, Interleukin-19, -20 and -24 bind IL20RA/IL20RB receptor subunits and Interleukin-20 and -24 bind IL22RA1/IL20RB receptor subunits.


go_id: GO:0030877
term: beta-catenin destruction complex
ontology: CC
definition:
A cytoplasmic protein complex containing glycogen synthase kinase-3-beta (GSK-3-beta), the adenomatous polyposis coli protein (APC), and the scaffolding protein axin, among others; phosphorylates beta-catenin, targets it for degradation by the proteasome.


go_id: GO:0030878
term: thyroid gland development
ontology: BP
definition:
The process whose specific outcome is the progression of the thyroid gland over time, from its formation to the mature structure. The thyroid gland is an endoderm-derived gland that produces thyroid hormone.


go_id: GO:0030879
term: mammary gland development
ontology: BP
definition:
The process whose specific outcome is the progression of the mammary gland over time, from its formation to the mature structure. The mammary gland is a large compound sebaceous gland that in female mammals is modified to secrete milk. Its development starts with the formation of the mammary line and ends as the mature gland cycles between nursing and weaning stages.


go_id: GO:0030880
term: RNA polymerase complex
ontology: CC
definition:
Any complex that possesses RNA polymerase activity; generally comprises a catalytic subunit and one or more additional subunits.


go_id: GO:0030886
term: negative regulation of myeloid dendritic cell activation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of myeloid dendritic cell activation.


go_id: GO:0030891
term: VCB complex
ontology: CC
definition:
A protein complex that possesses ubiquitin ligase activity; the complex is usually pentameric; for example, in mammals the subunits are pVHL, elongin B, elongin C, cullin-2 (Cul2), and Rbx1.


go_id: GO:0030892
term: mitotic cohesin complex
ontology: CC
definition:
A cohesin complex that mediates sister chromatid cohesion during mitosis; has a subunit composition distinct from that of the meiotic cohesin complex.


go_id: GO:0030893
term: meiotic cohesin complex
ontology: CC
definition:
A cohesin complex that mediates sister chromatid cohesion during meiosis; has a subunit composition distinct from that of the mitotic cohesin complex.


go_id: GO:0030894
term: replisome
ontology: CC
definition:
A multi-component enzymatic machine at the replication fork which mediates DNA replication. Includes DNA primase, one or more DNA polymerases, DNA helicases, and other proteins.


go_id: GO:0030895
term: apolipoprotein B mRNA editing enzyme complex
ontology: CC
definition:
Protein complex that mediates editing of the mRNA encoding apolipoprotein B; catalyzes the deamination of C to U (residue 6666 in the human mRNA). Contains a catalytic subunit, APOBEC-1, and other proteins (e.g. human ASP; rat ASP and KSRP).


go_id: GO:0030896
term: checkpoint clamp complex
ontology: CC
definition:
Conserved heterotrimeric complex of PCNA-like proteins that is loaded onto DNA at sites of DNA damage.


go_id: GO:0030897
term: HOPS complex
ontology: CC
definition:
A multimeric protein complex that associates with the vacuolar membrane, late endosomal (multivesicular body) and lysosomal membranes. HOPS is a tethering complex involved in vesicle fusion.


go_id: GO:0030899
term: calcium-dependent ATPase activity
ontology: MF
definition:
Catalysis of the reaction: ATP + H2O = ADP + phosphate. This reaction requires the presence of calcium ion (Ca2+).


go_id: GO:0030900
term: forebrain development
ontology: BP
definition:
The process whose specific outcome is the progression of the forebrain over time, from its formation to the mature structure. The forebrain is the anterior of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes especially the cerebral hemispheres, the thalamus, and the hypothalamus and especially in higher vertebrates is the main control center for sensory and associative information processing, visceral functions, and voluntary motor functions).


go_id: GO:0030901
term: midbrain development
ontology: BP
definition:
The process whose specific outcome is the progression of the midbrain over time, from its formation to the mature structure. The midbrain is the middle division of the three primary divisions of the developing chordate brain or the corresponding part of the adult brain (in vertebrates, includes a ventral part containing the cerebral peduncles and a dorsal tectum containing the corpora quadrigemina and that surrounds the aqueduct of Sylvius connecting the third and fourth ventricles).


go_id: GO:0030902
term: hindbrain development
ontology: BP
definition:
The process whose specific outcome is the progression of the hindbrain over time, from its formation to the mature structure. The hindbrain is the posterior of the three primary divisions of the developing chordate brain, or the corresponding part of the adult brain (in vertebrates, includes the cerebellum, pons, and medulla oblongata and controls the autonomic functions and equilibrium).


go_id: GO:0030903
term: notochord development
ontology: BP
definition:
The process whose specific outcome is the progression of the notochord over time, from its formation to the mature structure. The notochord is a mesoderm-derived structure located ventral of the developing nerve cord. In vertebrates, the notochord serves as a core around which other mesodermal cells form the vertebrae. In the most primitive chordates, which lack vertebrae, the notochord persists as a substitute for a vertebral column.


go_id: GO:0030904
term: retromer complex
ontology: CC
definition:
A conserved hetero-pentameric membrane-associated complex involved in retrograde transport from endosomes to the Golgi apparatus. The budding yeast retromer comprises Vps35p, Vps29p, Vps26p, Vps5p, and Vps17p. The mammalian complex shows slight variation in composition compared to yeast, and comprises SNX1 or SNX2, SNX5 or SNX6, VPS26A or VPS26B, VPS29, and VPS35.


go_id: GO:0030905
term: retromer, tubulation complex
ontology: CC
definition:
The dimeric subcomplex of the retromer, believed to be peripherally associated with the membrane. This dimeric complex is responsible for remodelling endosomal membranes to form a tube-structure to which cargo molecules are selected for recycling. The budding yeast complex comprises Vps5p and Vps17p, and may contain multiple copies of a Vps5p/Vps17p dimer. The mammalian complex contains SNX1 or SNX2 dimerized with SNX5 or SNX6.


go_id: GO:0030906
term: retromer, cargo-selective complex
ontology: CC
definition:
The trimeric subcomplex of the retromer, believed to be closely associated with the membrane. This trimeric complex is responsible for recognizing and binding to cargo molecules. The complex comprises three Vps proteins in both yeast and mammalian cells: Vps35p, Vps29p, and Vps26p in yeast, and VPS35, VPS29 and VPS26A or VPS26B in mammals.


go_id: GO:0030907
term: MBF transcription complex
ontology: CC
definition:
A protein complex that binds to the Mlu1 cell cycle box (MCB) promoter element, consensus sequence ACGCGN, and is involved in regulation of transcription during the G1/S transition of the cell cycle. In Saccharomyces, the complex contains a heterodimer of the DNA binding protein Mbp1p and the activator Swi6p, and is associated with additional proteins known as Nrm1p, Msa1p, and Msa2p; in Schizosaccharomyces the complex contains Res1p, Res2p, and Cdc10p.


go_id: GO:0030909
term: non-intein-mediated protein splicing
ontology: BP
definition:
The post-translational removal of peptide sequences from within a protein sequence, by a process not involving inteins.


go_id: GO:0030910
term: olfactory placode formation
ontology: BP
definition:
The formation of a thickening of the neural ectoderm in the head region of the vertebrate embryo which develops into the olfactory region of the nasal cavity.


go_id: GO:0030911
term: TPR domain binding
ontology: MF
definition:
Binding to a tetratricopeptide repeat (TPR) domain of a protein, the consensus sequence of which is defined by a pattern of small and large hydrophobic amino acids and a structure composed of helices.


go_id: GO:0030912
term: response to deep water
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a deep water stimulus, being immersed in standing deep water throughout the life cycle.


go_id: GO:0030913
term: paranodal junction assembly
ontology: BP
definition:
Formation of the junction between an axon and the glial cell that forms the myelin sheath. Paranodal junctions form at each paranode, i.e. at the ends of the unmyelinated nodes of Ranvier.


go_id: GO:0030915
term: Smc5-Smc6 complex
ontology: CC
definition:
A conserved complex that contains a heterodimer of SMC proteins (Smc5p and Smc6p, or homologs thereof) and several other proteins, and is involved in DNA repair and maintaining cell cycle arrest following DNA damage. In S. cerevisiae, this is an octameric complex called Mms21-Smc5-Smc6 complex, with at least five of its subunits conserved in fission yeast and humans.


go_id: GO:0030916
term: otic vesicle formation
ontology: BP
definition:
The process resulting in the transition of the otic placode into the otic vesicle, a transient embryonic structure formed during development of the vertebrate inner ear.


go_id: GO:0030917
term: midbrain-hindbrain boundary development
ontology: BP
definition:
The process whose specific outcome is the progression of the midbrain-hindbrain boundary over time, from its formation to the mature structure. The midbrain-hindbrain domain of the embryonic brain is comprised of the mesencephalic vesicle and the first rhombencephalic vesicle at early somitogenesis stages.


go_id: GO:0030921
term: peptidyl-tyrosine dehydrogenation to form (Z)-2,3-didehydrotyrosine
ontology: BP
definition:
The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(Z)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues.


go_id: GO:0030922
term: peptidyl-tyrosine dehydrogenation to form (E)-2,3-didehydrotyrosine
ontology: BP
definition:
The oxidation of the C alpha-C beta bond of peptidyl-tyrosine to form peptidyl-(E)-2,3-didehydrotyrosine coupled with cyclization of neighboring residues.


go_id: GO:0030923
term: metal incorporation into metallo-oxygen cluster
ontology: BP
definition:
The formation of a cluster of several metal atoms, including manganese or calcium, with one or more bridging (mu-bond) oxygen atoms; amino acids residues in proteins that may ligate the metal oxygen cluster are histidine, aspartate, and glutamate.


go_id: GO:0030926
ontology: BP
term:
calcium incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide

definition:
The incorporation of calcium into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site.


go_id: GO:0030927
ontology: BP
term:
manganese incorporation into metallo-oxygen cluster via bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide

definition:
The incorporation of manganese into a 4Mn-Ca-4O complex by bis-L-aspartato tris-L-glutamato L-histidino calcium tetramanganese tetroxide as in the photosystem II catalytic site.


go_id: GO:0030929
term: ADPG pyrophosphorylase complex
ontology: CC
definition:
Complex that possesses ADPG pyrophosphorylase activity. In all organisms where it has been found, the complex is a tetramer. In bacteria, it is a homotetramer. In plants, the complex is a heterotetramer composed small and large subunits.


go_id: GO:0030930
term: homotetrameric ADPG pyrophosphorylase complex
ontology: CC
definition:
A protein complex composed of four identical subunits that possesses ADPG pyrophosphorylase activity. Examples of this component are found in Bacterial species.


go_id: GO:0030931
term: heterotetrameric ADPG pyrophosphorylase complex
ontology: CC
definition:
A protein complex composed of four different subunits that possesses ADPG pyrophosphorylase activity. An example of this process is found in Mus musculus.


go_id: GO:0030934
term: anchoring collagen complex
ontology: CC
definition:
Any collagen complex which links one collagen assembly, such as a collagen fibril or sheet, to other structures.


go_id: GO:0030935
term: sheet-forming collagen trimer
ontology: CC
definition:
A protein complex consisting of three collagen chains assembled into a left-handed triple helix. These trimers assemble into a sheet.


go_id: GO:0030937
term: collagen type XVII trimer
ontology: CC
definition:
A collagen homotrimer of alpha1(XVII) chains; type XVII collagen triple helices span the plasma membrane and associate with hemidesmosomes and the basal lamina where they bind laminin.


go_id: GO:0030941
term: chloroplast targeting sequence binding
ontology: MF
definition:
Binding to a chloroplast targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the chloroplast.


go_id: GO:0030942
term: endoplasmic reticulum signal peptide binding
ontology: MF
definition:
Binding to an endoplasmic reticulum signal peptide, a specific peptide sequence that acts as a signal to localize the protein within the endoplasmic reticulum.


go_id: GO:0030943
term: mitochondrion targeting sequence binding
ontology: MF
definition:
Binding to a mitochondrion targeting sequence, a specific peptide sequence that acts as a signal to localize the protein within the mitochondrion.


go_id: GO:0030944
term: DDEL sequence binding
ontology: MF
definition:
Binding to a KDEL sequence, the C terminus tetrapeptide sequence Asp-Asp-Glu-Leu found in proteins that are to be retained in the endoplasmic reticulum.


go_id: GO:0030945
term: protein tyrosine phosphatase activity, via thiol-phosphate intermediate
ontology: MF
definition:
The catalysis of phosphate removal from a phosphotyrosine using cysteine as a nucleophile and proceed by means of a thiol-phosphate intermediate.


go_id: GO:0030946
term: protein tyrosine phosphatase activity, metal-dependent
ontology: MF
definition:
Catalysis of the reaction: protein tyrosine phosphate + H2O = protein tyrosine + phosphate. This reaction requires metal ions.


go_id: GO:0030947
term: regulation of vascular endothelial growth factor receptor signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.


go_id: GO:0030948
term: negative regulation of vascular endothelial growth factor receptor signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.


go_id: GO:0030949
term: positive regulation of vascular endothelial growth factor receptor signaling pathway
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of vascular endothelial growth factor receptor signaling pathway activity.


go_id: GO:0030950
term: establishment or maintenance of actin cytoskeleton polarity
ontology: BP
definition:
Any cellular process that results in the specification, formation or maintenance of polarized actin-based cytoskeletal structures.


go_id: GO:0030951
term: establishment or maintenance of microtubule cytoskeleton polarity
ontology: BP
definition:
Any cellular process that results in the specification, formation or maintenance of polarized microtubule-based cytoskeletal structures.


go_id: GO:0030952
term: establishment or maintenance of cytoskeleton polarity
ontology: BP
definition:
Any cellular process that results in the specification, formation or maintenance of polarized cytoskeletal structures.


go_id: GO:0030953
term: astral microtubule organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of astral microtubules, any of the spindle microtubules that radiate in all directions from the spindle poles.


go_id: GO:0030954
term: astral microtubule nucleation
ontology: BP
definition:
The 'de novo' formation of an astral microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule.


go_id: GO:0030956
term: glutamyl-tRNA(Gln) amidotransferase complex
ontology: CC
definition:
A protein complex that possesses glutamyl-tRNA(Gln) amidotransferase activity, and therefore creates Gln-tRNA by amidating Glu-tRNA; usually composed of 3 subunits: A, B, and C. Note that the C subunit may not be required in all organisms.


go_id: GO:0030957
term: Tat protein binding
ontology: MF
definition:
Binding to Tat, a viral transactivating regulatory protein from the human immunodeficiency virus, or the equivalent protein from another virus.


go_id: GO:0030958
term: RITS complex
ontology: CC
definition:
A protein complex required for heterochromatin assembly; contains an Argonaute homolog, a chromodomain protein, and at least one additional protein; named for RNA-induced initiation of transcriptional gene silencing.


go_id: GO:0030959
term: peptide cross-linking via 3'-(3'-L-tyrosinyl)-L-tyrosine
ontology: BP
definition:
The modification of two peptidyl-tyrosines to form a 3'-(3'-L-tyrosinyl)-L-tyrosine protein cross-link.


go_id: GO:0030960
term: peptide cross-linking via 3'-(O4'-L-tyrosinyl)-L-tyrosine
ontology: BP
definition:
The modification of two peptidyl-tyrosines to form a 3'-(O4'-L-tyrosinyl)-L-tyrosine protein cross-link.


go_id: GO:0030964
term: NADH dehydrogenase complex
ontology: CC
definition:
An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone.


go_id: GO:0030965
term: plasma membrane electron transport, NADH to quinone
ontology: BP
definition:
The transfer of electrons from NADH to the quinone pool that occurs during oxidative phosphorylation and results in the generation of a proton gradient, mediated by the enzyme known as NADH-quinone oxidoreductase.


go_id: GO:0030968
term: endoplasmic reticulum unfolded protein response
ontology: BP
definition:
The series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) or other ER-related stress; results in changes in the regulation of transcription and translation.


go_id: GO:0030970
term: retrograde protein transport, ER to cytosol
ontology: BP
definition:
The directed movement of unfolded or misfolded proteins from the endoplasmic reticulum to the cytosol through the translocon.


go_id: GO:0030975
term: thiamine binding
ontology: MF
definition:
Binding to thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver.


go_id: GO:0030976
term: thiamine pyrophosphate binding
ontology: MF
definition:
Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases.


go_id: GO:0030978
term: alpha-glucan metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds.


go_id: GO:0030979
term: alpha-glucan biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of alpha-glucans, compounds composed of glucose residues linked by alpha-D-glucosidic bonds.


go_id: GO:0030982
term: adventurous gliding motility
ontology: BP
definition:
A process involved in the controlled movement of a bacterial cell powered by the rearward secretion of carbohydrate slime.


go_id: GO:0030988
term: high molecular weight kininogen receptor complex
ontology: CC
definition:
A protein complex that acts as a receptor for high molecular weight kininogens. In humans, this receptor includes the CK1 and uPAR proteins.


go_id: GO:0030989
term: dynein-driven meiotic oscillatory nuclear movement
ontology: BP
definition:
Oscillatory movement of the nucleus involved in meiosis I. This oscillatory movement is led by an astral microtubule array emanating from the spindle pole body, and driven by the microtubule motor cytoplasmic dynein.


go_id: GO:0030990
term: intraciliary transport particle
ontology: CC
definition:
A nonmembrane-bound oligomeric protein complex that participates in bidirectional transport of molecules (cargo) along axonemal microtubules.


go_id: GO:0030991
term: intraciliary transport particle A
ontology: CC
definition:
The smaller subcomplex of the intraciliary transport particle; characterized complexes have molecular weights of 710-760 kDa.


go_id: GO:0030992
term: intraciliary transport particle B
ontology: CC
definition:
The larger subcomplex of the intraciliary transport particle; characterized complexes have molecular weights around 550 kDa.


go_id: GO:0030993
term: axonemal heterotrimeric kinesin-II complex
ontology: CC
definition:
A kinesin complex found in eukaryotic axonemes that contains two distinct plus end-directed kinesin motor proteins and at least one accessory subunit, and that functions in the anterograde transport of molecules (cargo) from the basal body to the distal tip of the axoneme.


go_id: GO:0030995
term: cell septum edging catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the dissolution of the septum edging during cell separation.


go_id: GO:0030997
term: regulation of centriole-centriole cohesion
ontology: BP
definition:
Any process that modulates the extent to which the two centrioles within a centrosome remain tightly paired; may be mediated by the assembly and disassembly of a proteinaceous linker.


go_id: GO:0030998
term: linear element
ontology: CC
definition:
A proteinaceous scaffold associated with fission yeast chromosomes during meiotic prophase. Linear elements consist of a protein complex, LinE, with four main structural components (Rec10, Rec25, Rec27, and Mug20 in S. pombe) associated with chromatin. The resulting structure is related to but not equivalent to the synaptonemal complex.


go_id: GO:0030999
term: linear element assembly
ontology: BP
definition:
The cell cycle process in which linear elements are assembled in association with fission yeast chromosomes during meiotic prophase. Linear element assembly begins with LinE complex formation and ends when LinE complexes are associated with chromatin in structures visible as nuclear foci. A linear element is a proteinaceous scaffold related to the synaptonemal complex.


go_id: GO:0031000
term: response to caffeine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a caffeine stimulus. Caffeine is an alkaloid found in numerous plant species, where it acts as a natural pesticide that paralyzes and kills certain insects feeding upon them.


go_id: GO:0031001
term: response to brefeldin A
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a brefeldin A stimulus.


go_id: GO:0031002
term: actin rod
ontology: CC
definition:
A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and associated proteins. Actin rod structures are found in diverse organisms, having been observed in spores of Dictyostelium discoideum, Drosophila melanogaster oocytes, as well as in numerous animal cells under stress conditions.


go_id: GO:0031003
term: actin tubule
ontology: CC
definition:
A cellular structure, approximately 13 nm in diameter, consisting of three actin filaments bundled together.


go_id: GO:0031004
term: potassium ion-transporting ATPase complex
ontology: CC
definition:
Protein complex that carries out the reaction: ATP + H2O + K+(out) = ADP + phosphate + K+(in). It is a high affinity potassium uptake system. The E. coli complex consists of 4 proteins: KdpA is the potassium ion translocase, KdpB is the ATPase, and KdpC and KdpF seem to be involved in assembly and stabilization of the complex.


go_id: GO:0031005
term: filamin binding
ontology: MF
definition:
Binding to a filamin, any member of a family of high molecular mass cytoskeletal proteins that crosslink actin filaments to form networks and stress fibers. Filamins contain an amino-terminal alpha-actinin-like actin binding domain, which is followed by a rod-domain composed of 4 to 24 100-residue repetitive segments including a carboxy-terminal dimerization domain.


go_id: GO:0031010
term: ISWI-type complex
ontology: CC
definition:
Any nuclear protein complex that contains an ATPase subunit of the imitation switch (ISWI) family. ISWI ATPases are involved in assembling chromatin and in sliding and spacing nucleosomes to regulate transcription of nuclear RNA polymerases I, II, and III and also DNA replication, recombination and repair.


go_id: GO:0031011
term: Ino80 complex
ontology: CC
definition:
A multisubunit protein complex that contains the Ino80p ATPase; exhibits chromatin remodeling activity.


go_id: GO:0031012
term: extracellular matrix
ontology: CC
definition:
A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues.


go_id: GO:0031016
term: pancreas development
ontology: BP
definition:
The process whose specific outcome is the progression of the pancreas over time, from its formation to the mature structure. The pancreas is an endoderm derived structure that produces precursors of digestive enzymes and blood glucose regulating enzymes.


go_id: GO:0031017
term: exocrine pancreas development
ontology: BP
definition:
The process whose specific outcome is the progression of the exocrine pancreas over time, from its formation to the mature structure. The exocrine pancreas produces and store zymogens of digestive enzymes, such as chymotrypsinogen and trypsinogen in the acinar cells.


go_id: GO:0031018
term: endocrine pancreas development
ontology: BP
definition:
The process whose specific outcome is the progression of the endocrine pancreas over time, from its formation to the mature structure. The endocrine pancreas is made up of islet cells that produce insulin, glucagon and somatostatin.


go_id: GO:0031019
term: mitochondrial mRNA editing complex
ontology: CC
definition:
An mRNA editing complex found in the mitochondrion. The best characterized example is that of Trypanosoma brucei, which catalyzes the insertion and deletion of uridylates.


go_id: GO:0031021
term: interphase microtubule organizing center
ontology: CC
definition:
A microtubule organizing center found in interphase cells, which organize a longitudinal array of three to five MT bundles from the nuclear envelope during interphase. Each MT bundle is composed of two to seven MTs arranged in an antiparallel configuration, with the dynamic MT plus ends extending toward the cell tips and stable minus ends near the nucleus.


go_id: GO:0031022
term: nuclear migration along microfilament
ontology: BP
definition:
The directed movement of the nucleus along microfilaments within the cell, mediated by motor proteins.


go_id: GO:0031023
term: microtubule organizing center organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microtubule organizing center, a structure from which microtubules grow.


go_id: GO:0031024
term: interphase microtubule organizing center assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components, including gamma-tubulin and other proteins, to form an interphase microtubule organizing center.


go_id: GO:0031025
term: equatorial microtubule organizing center disassembly
ontology: BP
definition:
The process in which the equatorial microtubule organizing center is disassembled at the end of mitosis.


go_id: GO:0031027
term: glutamate synthase complex (NADH)
ontology: CC
definition:
A protein complex that in yeast consists of a large and a small subunit. Possesses glutamate synthase (NADH) activity.


go_id: GO:0031028
term: septation initiation signaling
ontology: BP
definition:
The series of molecular signals, mediated by the small GTPase Ras, that results in the initiation of contraction of the contractile ring, at the beginning of cytokinesis and cell division by septum formation. The pathway coordinates chromosome segregation with mitotic exit and cytokinesis.


go_id: GO:0031030
term: negative regulation of septation initiation signaling
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of septation initiation signaling.


go_id: GO:0031031
term: positive regulation of septation initiation signaling
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of septation initiation signaling.


go_id: GO:0031032
term: actomyosin structure organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures containing both actin and myosin or paramyosin. The myosin may be organized into filaments.


go_id: GO:0031033
term: myosin filament organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a filament composed of myosin molecules.


go_id: GO:0031038
term: myosin II filament organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a bipolar filament composed of myosin II molecules.


go_id: GO:0031039
term: macronucleus
ontology: CC
definition:
A membrane-bounded organelle of ciliated protozoan cells that contains polyploid copies of a portion of the cell's complete genome. Transcription of genes occurs in macronuclei. Some ciliate species may contain multiple macronuclei per cell.


go_id: GO:0031040
term: micronucleus
ontology: CC
definition:
A membrane-bounded organelle of ciliated protozoan cells that contains a diploid copy of the cell's complete genome. Sections of contiguous sequence in the macronucleus are often interrupted by internal eliminated sequences (IES), and may be permuted, in micronuclei. Genic transcription is not found in micronuclei. Some ciliate species may contain multiple micronuclei per cell.


go_id: GO:0031041
term: O-glycan processing, core 5
ontology: BP
definition:
The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 5 O-glycan structure, GalNAc-alpha-(1->3)-GalNAc.


go_id: GO:0031042
term: O-glycan processing, core 6
ontology: BP
definition:
The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 6 O-glycan structure, GlcNAc-beta-(1->6)-GalNAc.


go_id: GO:0031043
term: O-glycan processing, core 7
ontology: BP
definition:
The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 7 O-glycan structure, GalNAc-alpha-(1->6)-GalNAc.


go_id: GO:0031044
term: O-glycan processing, core 8
ontology: BP
definition:
The stepwise addition of carbohydrate or carbohydrate derivative residues to the initially added O-linked residue (usually GalNAc) to form the core 8 O-glycan structure, Gal-alpha-(1->3)-GalNAc.


go_id: GO:0031045
term: dense core granule
ontology: CC
definition:
Electron-dense organelle with a granular internal matrix; contains proteins destined to be secreted.


go_id: GO:0031047
term: gene silencing by RNA
ontology: BP
definition:
A process in which an RNA molecule reduces expression of target genes. This can occur pre-transcriptionally by assembly of heterochromatin and prevention of transcription or co- or post-transcriptionally by targeting RNAs for degradation or by interfering with splicing or translation. This process starts once the inhibitory RNA molecule has been transcribed, and includes processing of the RNA such as cleavage, modifications, transport from the nucleus to the cytoplasm, loading onto the RISC complex, and the effect on transcription or translation.


go_id: GO:0031048
term: small non-coding RNA-dependent heterochromatin formation
ontology: BP
definition:
A heterochromatin formation-based gene silencing process mediated by a small RNA molecule that occur before the beginnning of trancription.


go_id: GO:0031049
term: programmed DNA elimination
ontology: BP
definition:
A process in which genomic fragments or entire chromosomes are eliminated from somatic cells or from micronuclei of ciliates. This process occurs in the developing macronucleus (anlage) of a ciliate, as well as in other species, including vertebrates and is an irreversible mechanism of gene silencing.


go_id: GO:0031052
term: programmed DNA elimination by chromosome breakage
ontology: BP
definition:
Regulated cleavage of the developing macronuclear genome at a limited number of chromosome breakage sites (CBS). The macronuclear destined segment (MDS) sequence adjacent to the CBS (or separated from it by a BES) receives a macronuclear telomere following chromosome breakage.


go_id: GO:0031057
term: negative regulation of histone modification
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of a histone.


go_id: GO:0031058
term: positive regulation of histone modification
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the covalent alteration of a histone.


go_id: GO:0031060
term: regulation of histone methylation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the covalent addition of methyl groups to histones.


go_id: GO:0031061
term: negative regulation of histone methylation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent addition of methyl groups to histones.


go_id: GO:0031062
term: positive regulation of histone methylation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the covalent addition of methyl groups to histones.


go_id: GO:0031063
term: regulation of histone deacetylation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones.


go_id: GO:0031064
term: negative regulation of histone deacetylation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups from histones.


go_id: GO:0031065
term: positive regulation of histone deacetylation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones.


go_id: GO:0031066
term: regulation of histone deacetylation at centromere
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA.


go_id: GO:0031067
term: negative regulation of histone deacetylation at centromere
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the removal of acetyl groups to histones in centromeric DNA.


go_id: GO:0031068
term: positive regulation of histone deacetylation at centromere
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the removal of acetyl groups from histones in centromeric DNA.


go_id: GO:0031070
term: intronic snoRNA processing
ontology: BP
definition:
The biogenesis of a snoRNA molecule which resides within, and is processed from, the intron of a pre-mRNA.


go_id: GO:0031071
term: cysteine desulfurase activity
ontology: MF
definition:
Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine.


go_id: GO:0031073
term: cholesterol 26-hydroxylase activity
ontology: MF
definition:
Catalysis of the hydroxylation of cholesterol at position 26 of the side chain, to produce 26-hydroxycholesterol.


go_id: GO:0031076
term: embryonic camera-type eye development
ontology: BP
definition:
The process occurring during the embryonic phase whose specific outcome is the progression of the eye over time, from its formation to the mature structure.


go_id: GO:0031077
term: post-embryonic camera-type eye development
ontology: BP
definition:
The process occurring during the post-embryonic phase whose specific outcome is the progression of the camera-type eye over time, from its formation to the mature structure.


go_id: GO:0031078
term: histone deacetylase activity (H3-K14 specific)
ontology: MF
definition:
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein.


go_id: GO:0031080
term: nuclear pore outer ring
ontology: CC
definition:
A subcomplex of the nuclear pore complex (NPC) that forms the outer rings of the core scaffold, a lattice-like structure that gives the NPC its shape and strength. In S. cerevisiae, the two outer rings each contain multiple copies of the following proteins: Nup133p, Nup120p, Nup145Cp, Nup85p, Nup84p, Seh1p, and Sec13p. In vertebrates, the two outer rings each contain multiple copies of the following proteins: Nup133, Nup160, Nup96, Nup75, Nup107, Seh1, Sec13, Nup43, Nup37, and ALADIN. Components are arranged in 8-fold symmetrical 'spokes' around the central transport channel. A single 'spoke', can be isolated and is sometimes referred to as the Nup84 complex (S. cerevisiae) or the Nup107-160 complex (vertebrates).


go_id: GO:0031082
term: BLOC complex
ontology: CC
definition:
Any of several protein complexes required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes, platelet dense granules, and other related organelles; acronym for biogenesis of lysosomal-related organelles complex.


go_id: GO:0031083
term: BLOC-1 complex
ontology: CC
definition:
A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. Many of the protein subunits are conserved between mouse and human; the mouse complex contains the Pallidin, Muted, Cappuccino, Dysbindin, Snapin, BLOS1, BLOS2, AND BLOS3 proteins.


go_id: GO:0031084
term: BLOC-2 complex
ontology: CC
definition:
A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps3, Hps5, and Hps6 proteins; the mouse complex contains ru2 and ru.


go_id: GO:0031085
term: BLOC-3 complex
ontology: CC
definition:
A protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules. The human complex contains the Hps1 and Hps4 proteins.


go_id: GO:0031086
term: nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
ontology: BP
definition:
A pathway of degradation of nuclear-transcribed mRNAs that proceeds through a series of steps that is independent of deadenylation, but requires decapping followed by transcript decay, and that can regulate mRNA stability.


go_id: GO:0031087
term: deadenylation-independent decapping of nuclear-transcribed mRNA
ontology: BP
definition:
Cleavage of the 5'-cap of a nuclear-transcribed mRNA that is independent of poly(A) tail shortening.


go_id: GO:0031090
term: organelle membrane
ontology: CC
definition:
A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.


go_id: GO:0031091
term: platelet alpha granule
ontology: CC
definition:
A secretory organelle found in blood platelets, which is unique in that it exhibits further compartmentalization and acquires its protein content via two distinct mechanisms: (1) biosynthesis predominantly at the megakaryocyte (MK) level (with some vestigial platelet synthesis) (e.g. platelet factor 4) and (2) endocytosis and pinocytosis at both the MK and circulating platelet levels (e.g. fibrinogen (Fg) and IgG).


go_id: GO:0031094
term: platelet dense tubular network
ontology: CC
definition:
A network of membrane-bounded compartments found in blood platelets, where they regulate platelet activation by sequestering or releasing calcium. The dense tubular network exists as thin elongated membranes in resting platelets, and undergoes a major ultrastructural change, to a rounded vesicular form, upon addition of thrombin.


go_id: GO:0031097
term: medial cortex
ontology: CC
definition:
A medial cortical band overlaying the nucleus which acts as a landmark for contractile ring positioning and plays a role in cell cycle regulation.


go_id: GO:0031098
term: stress-activated protein kinase signaling cascade
ontology: BP
definition:
The series of molecular signals in which a stress-activated protein kinase (SAPK) cascade relays a signal.


go_id: GO:0031099
term: regeneration
ontology: BP
definition:
The regrowth of a lost or destroyed body part, such as an organ or tissue. This process may occur via renewal, repair, and/or growth alone (i.e. increase in size or mass).


go_id: GO:0031105
term: septin complex
ontology: CC
definition:
A protein complex containing septins.  Typically, these complexes contain multiple septins and are oligomeric.


go_id: GO:0031109
term: microtubule polymerization or depolymerization
ontology: BP
definition:
Assembly or disassembly of microtubules by the addition or removal of tubulin heterodimers from a microtubule.


go_id: GO:0031110
term: regulation of microtubule polymerization or depolymerization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of microtubule polymerization or depolymerization by the addition or removal of tubulin heterodimers from a microtubule.


go_id: GO:0031111
term: negative regulation of microtubule polymerization or depolymerization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization or depolymerization.


go_id: GO:0031112
term: positive regulation of microtubule polymerization or depolymerization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of microtubule polymerization or depolymerization.


go_id: GO:0031115
term: negative regulation of microtubule polymerization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of microtubule polymerization.


go_id: GO:0031116
term: positive regulation of microtubule polymerization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of microtubule polymerization.


go_id: GO:0031117
term: positive regulation of microtubule depolymerization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of microtubule depolymerization.


go_id: GO:0031121
term: equatorial microtubule organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins at the midpoint of a cell.


go_id: GO:0031122
term: cytoplasmic microtubule organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of structures formed of microtubules and associated proteins in the cytoplasm of a cell.


go_id: GO:0031126
term: sno(s)RNA 3'-end processing
ontology: BP
definition:
Any process involved in forming the mature 3' end of a snoRNA family molecule, also referred to as an sRNA in Archaea.


go_id: GO:0031127
term: alpha-(1,2)-fucosyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of an L-fucosyl group from GDP-beta-L-fucose to an acceptor molecule to form an alpha-(1->2) linkage.


go_id: GO:0031128
term: developmental induction
ontology: BP
definition:
A developmental process involving two tissues in which one tissue (the inducer) produces a signal that directs cell fate commitment of cells in the second tissue (the responder).


go_id: GO:0031129
term: inductive cell-cell signaling
ontology: BP
definition:
Signaling at short range between cells of different ancestry and developmental potential that results in one cell or group of cells effecting a developmental change in the other. This is often done by secretion of proteins by one cell which affects the neighboring cells and causes them to adopt a certain fate.


go_id: GO:0031130
term: creation of an inductive signal
ontology: BP
definition:
The process in which one cell or group of cells sends a signal over a short range to another cell or group of cells of different ancestry and developmental potential, thereby effecting a developmental change in the latter.


go_id: GO:0031131
term: reception of an inductive signal
ontology: BP
definition:
The process in which one cell or group of cells receives, transduces, and responds to a signal generated by another cell or group of cells of different ancestry and developmental potential, such that the recipient cell(s) undergo a developmental change.


go_id: GO:0031133
term: regulation of axon diameter
ontology: BP
definition:
Any process that modulates the rate, direction or extent of axon growth such that the correct diameter is attained and maintained.


go_id: GO:0031134
term: sister chromatid biorientation
ontology: BP
definition:
The cell cycle process in which sister chromatids establish stable attachments to microtubules emanating from opposite spindle poles.


go_id: GO:0031140
term: induction of conjugation upon nutrient starvation
ontology: BP
definition:
The process in which a cell initiates conjugation with cellular fusion upon starvation for one or more nutrients.


go_id: GO:0031143
term: pseudopodium
ontology: CC
definition:
A temporary protrusion or retractile process of a cell, associated with flowing movements of the protoplasm, and serving for locomotion and feeding.


go_id: GO:0031145
term: anaphase-promoting complex-dependent catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by the anaphase-promoting complex, and mediated by the proteasome.


go_id: GO:0031146
term: SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, with ubiquitin-protein ligation catalyzed by an SCF (Skp1/Cul1/F-box protein) complex, and mediated by the proteasome.


go_id: GO:0031147
term: 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells.


go_id: GO:0031148
term: DIF-1 biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of 1-(3,5-dichloro-2,6-dihydroxy-4-methoxyphenyl)hexan-1-one, also known as DIF-1, differentiation-inducing factor-1. DIF-1 is a secreted chlorinated molecule that controls cell fate during development of Dictyostelium cells.


go_id: GO:0031149
term: sorocarp stalk cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a sorocarp stalk cell, any of the cellulose-covered cells that form the stalk of a sorocarp. An example of this process is found in Dictyostelium discoideum.


go_id: GO:0031150
term: sorocarp stalk development
ontology: BP
definition:
The process whose specific outcome is the progression of the sorocarp stalk over time, from its formation to the mature structure. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum.


go_id: GO:0031151
term: histone methyltransferase activity (H3-K79 specific)
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + histone H3 L-lysine (position 79) = S-adenosyl-L-homocysteine + histone H3 N6-methyl-L-lysine (position 79). This reaction is the addition of a methyl group onto lysine at position 79 of the histone H3 protein.


go_id: GO:0031152
term: aggregation involved in sorocarp development
ontology: BP
definition:
The process whose specific outcome is the progression of the aggregate over time, from its formation to the point when a slug is formed. Aggregate development begins in response to starvation and continues by the chemoattractant-mediated movement of cells toward each other. The aggregate is a multicellular structure that gives rise to the slug.


go_id: GO:0031153
term: slug development involved in sorocarp development
ontology: BP
definition:
The process whose specific outcome is the progression of the slug over time, from its formation to the mature structure. Slug development begins when the aggregate rises upwards to form a finger-shaped structure and ends when culmination begins. Slug development begins after aggregation and ends before culmination in sorocarp development.


go_id: GO:0031154
term: culmination involved in sorocarp development
ontology: BP
definition:
The process whose specific outcome is the progression of the culminant over time, from its formation to the mature structure. Culmination begins with a morphogenetic change of the finger-like or migratory slug giving rise to an organized structure containing a stalk and a sorus. This process is the final stage of sorocarp development.


go_id: GO:0031156
term: regulation of sorocarp development
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of sorocarp development. An example of this process is found in Dictyostelium discoideum.


go_id: GO:0031161
term: phosphatidylinositol catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of phosphatidylinositol, any glycophospholipid with its sn-glycerol 3-phosphate residue is esterified to the 1-hydroxyl group of 1D-myo-inositol.


go_id: GO:0031165
term: integral component of contractile vacuolar membrane
ontology: CC
definition:
The component of the contractile vacuolar membrane consisting of gene products that have some part that penetrates at least one leaflet of the membrane bilayer. This component includes gene products that are buried in the bilayer with no exposure outside the bilayer.


go_id: GO:0031166
term: integral component of vacuolar membrane
ontology: CC
definition:
The component of the vacuolar membrane consisting of gene products and protein complexes that have some part that penetrates at least one leaflet of the membrane bilayer. May also refer to the state of being buried in the bilayer with no exposure outside the bilayer.


go_id: GO:0031168
term: ferrichrome metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine.


go_id: GO:0031169
term: ferrichrome biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of a ferrichrome. Ferrichromes are any of a group of growth-promoting Fe(III) chelates formed by various genera of microfungi. They are homodetic cyclic hexapeptides made up of a tripeptide of glycine (or other small neutral amino acids) and a tripeptide of an N'acyl-N4-hydroxy-L-ornithine.


go_id: GO:0031170
term: ferricrocin metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3.


go_id: GO:0031171
term: ferricrocin biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of ferricrocin, a cyclic hexapeptide siderophore with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)3.


go_id: GO:0031173
term: otolith mineralization completed early in development
ontology: BP
definition:
The formation of otoliths during embryogenesis with completion in early postembryonic development. Formation occurs by precipitation of specific crystal forms of calcium carbonate around an organic core of extracellular matrix proteins. Otoconia (otoliths) are small (~10 micron) dense extracellular particles present in the otolith end organs of the vertebrate inner ear.


go_id: GO:0031174
term: lifelong otolith mineralization
ontology: BP
definition:
The formation and growth of otoliths throughout the life of the organism. Otoliths are the large extracellular ear-stones of the fish inner ear, produced by precipitation of specific crystal forms of calcium carbonate on organic matrices. The otolith enlarges throughout the life of the fish, as layers of calcium carbonate are added.


go_id: GO:0031175
term: neuron projection development
ontology: BP
definition:
The process whose specific outcome is the progression of a neuron projection over time, from its formation to the mature structure. A neuron projection is any process extending from a neural cell, such as axons or dendrites (collectively called neurites).


go_id: GO:0031179
term: peptide modification
ontology: BP
definition:
The covalent alteration of one or more amino acid residues within a peptide, resulting in a change in the properties of that peptide.


go_id: GO:0031201
term: SNARE complex
ontology: CC
definition:
A protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers. One well-characterized example is the neuronal SNARE complex formed of synaptobrevin 2, syntaxin 1a, and SNAP-25.


go_id: GO:0031203
term: post-translational protein targeting to membrane, docking
ontology: BP
definition:
The process in which the signal sequence of a translated protein binds to and forms a complex with the Sec complex.


go_id: GO:0031205
term: endoplasmic reticulum Sec complex
ontology: CC
definition:
An endoplasmic reticulum membrane-associated complex involved in the translocation of proteins that are targeted to the ER. In yeast, this complex consists of two subcomplexes, namely, the Sec61 complex and the Sec62/Sec63 complex.


go_id: GO:0031207
term: Sec62/Sec63 complex
ontology: CC
definition:
A protein complex involved in the posttranslational targeting of proteins to the ER. In yeast, it is a tetrameric complex consisting of Sec62p, Sec63p, Sec71p and Sec72p.


go_id: GO:0031208
term: POZ domain binding
ontology: MF
definition:
Binding to a POZ (poxvirus and zinc finger) domain of a protein, a protein-protein interaction domain found in many transcription factors.


go_id: GO:0031209
term: SCAR complex
ontology: CC
definition:
A pentameric complex that includes orthologues of human PIR121, Nap1, Abi, SCAR, and HSPC300 and regulates actin polymerization and/or depolymerization through small GTPase mediated signal transduction.


go_id: GO:0031210
term: phosphatidylcholine binding
ontology: MF
definition:
Binding to a phosphatidylcholine, a glycophospholipid in which a phosphatidyl group is esterified to the hydroxyl group of choline.


go_id: GO:0031211
term: endoplasmic reticulum palmitoyltransferase complex
ontology: CC
definition:
A complex of the endoplasmic reticulum that catalyzes S-palmitoylation, the addition of palmitate (C16:0) or other long-chain fatty acids to proteins at a cysteine residue.


go_id: GO:0031213
term: RSF complex
ontology: CC
definition:
An ISWI complex that contains an ATPase subunit of the ISWI family (SNF2H in mammals) and an RSF1 homolog. It mediates nucleosome deposition and generates regularly spaced nucleosome arrays. In mammals, RSF is involved in regulation of transcription from RNA polymerase II promoters).


go_id: GO:0031214
term: biomineral tissue development
ontology: BP
definition:
Formation of hard tissues that consist mainly of inorganic compounds, and also contain a small amounts of organic matrices that are believed to play important roles in their formation.


go_id: GO:0031217
term: glucan 1,4-beta-glucosidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of (1->4) linkages in (1->4)-beta-D-glucans, to remove successive glucose units.


go_id: GO:0031219
term: levanase activity
ontology: MF
definition:
Catalysis of the random hydrolysis of 2,6-beta-D-fructofuranosidic linkages in 2,6-beta-D-fructans (levans) containing more than 3 fructose units.


go_id: GO:0031221
term: arabinan metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving arabinan, a polysaccharide composed of arabinose residues.


go_id: GO:0031222
term: arabinan catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of arabinan, a polysaccharide composed of arabinose residues.


go_id: GO:0031224
term: intrinsic component of membrane
ontology: CC
definition:
The component of a membrane consisting of the gene products having some covalently attached portion, for example part of a peptide sequence or some other covalently attached group such as a GPI anchor, which spans or is embedded in one or both leaflets of the membrane.


go_id: GO:0031225
term: anchored component of membrane
ontology: CC
definition:
The component of a membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group that is embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.


go_id: GO:0031226
term: intrinsic component of plasma membrane
ontology: CC
definition:
The component of the plasma membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031227
term: intrinsic component of endoplasmic reticulum membrane
ontology: CC
definition:
The component of the endoplasmic reticulum membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031228
term: intrinsic component of Golgi membrane
ontology: CC
definition:
The component of the Golgi membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031229
term: intrinsic component of nuclear inner membrane
ontology: CC
definition:
The component of the nuclear inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031230
term: intrinsic component of cell outer membrane
ontology: CC
definition:
The component of the cell outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031231
term: intrinsic component of peroxisomal membrane
ontology: CC
definition:
The component of the peroxisomal membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031232
term: extrinsic component of external side of plasma membrane
ontology: CC
definition:
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.


go_id: GO:0031233
term: intrinsic component of external side of plasma membrane
ontology: CC
definition:
The component of a plasma membrane consisting of gene products and protein complexes that penetrate the external side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor.


go_id: GO:0031234
term: extrinsic component of cytoplasmic side of plasma membrane
ontology: CC
definition:
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its cytoplasmic surface, but not integrated into the hydrophobic region.


go_id: GO:0031235
term: intrinsic component of the cytoplasmic side of the plasma membrane
ontology: CC
definition:
The component of a plasma membrane consisting of gene products and protein complexes that have some covalently attached part (e.g. peptide sequence or GPI anchor) which is embedded in the cytoplasmic side of the plasma membrane only.


go_id: GO:0031236
term: extrinsic component of periplasmic side of plasma membrane
ontology: CC
definition:
The component of a plasma membrane consisting of gene products and protein complexes that are loosely bound to its periplasmic surface, but not integrated into the hydrophobic region.


go_id: GO:0031237
term: intrinsic component of periplasmic side of plasma membrane
ontology: CC
definition:
The component of a plasma membrane consisting of gene products and protein complexes that penetrate the periplasmic side of the plasma membrane only, either directly or via some covalently attached hydrophobic anchor.


go_id: GO:0031242
term: extrinsic component of external side of cell outer membrane
ontology: CC
definition:
The component of a cell outer membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.


go_id: GO:0031243
term: intrinsic component of external side of cell outer membrane
ontology: CC
definition:
The component of the cell outer membrane consisting of the gene products and protein complexes that penetrate the external side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor.


go_id: GO:0031244
term: extrinsic component of cell outer membrane
ontology: CC
definition:
The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0031245
term: extrinsic component of periplasmic side of cell outer membrane
ontology: CC
definition:
The component of the cell outer membrane consisting of gene products and protein complexes that are loosely bound to periplasmic surface, but not integrated into the hydrophobic region.


go_id: GO:0031246
term: intrinsic component of periplasmic side of cell outer membrane
ontology: CC
definition:
The component of the cell outer membrane consisting of the gene products that that penetrate the periplasmic side of the cell outer membrane only, either directly or via some covalently attached hydrophobic anchor.


go_id: GO:0031247
term: actin rod assembly
ontology: BP
definition:
The assembly of actin rods, a cellular structure consisting of parallel, hexagonally arranged actin tubules.


go_id: GO:0031250
term: anaerobic ribonucleoside-triphosphate reductase complex
ontology: CC
definition:
An enzyme complex composed of 4 subunits, 2 copies of the large protein (nrdD in E. coli) and 2 copies of the small protein (nrdG in E. coli). It catalyzes the generation of 2'deoxyribonucleotides under anaerobic growth conditions. The larger subunit is the catalytic unit that is activated by the smaller iron-binding subunit.


go_id: GO:0031251
term: PAN complex
ontology: CC
definition:
A complex that possesses poly(A)-specific ribonuclease activity; catalyzes the message-specific shortening of mRNA poly(A) tails. Contains at least two subunits, known as Pan2p and Pan3p in Saccharomyces.


go_id: GO:0031261
term: DNA replication preinitiation complex
ontology: CC
definition:
A protein-DNA complex assembled at eukaryotic DNA replication origins immediately prior to the initiation of DNA replication. The preinitiation complex is formed by the assembly of additional proteins onto an existing prereplicative complex. In budding yeast, the additional proteins might include Cdc45p, Sld2p, Sld3p, Dpb11p, DNA polymerases, and others; in fission yeast the GINS complex is present.


go_id: GO:0031262
term: Ndc80 complex
ontology: CC
definition:
An outer kinetochore protein complex that is part of the KMN kinetochore network (also known as the NMS complex) providing the platform with which the plus ends of spindle microtubules directly interact to form stable kinetochore-microtubule attachments. A common subunit nomenclature is used from yeast to human: Ndc80, Nuf2, Spc24, and Spc25.


go_id: GO:0031264
term: death-inducing signaling complex
ontology: CC
definition:
A protein complex formed by the association of signaling proteins with a death receptor upon ligand binding. The complex includes procaspases and death domain-containing proteins in addition to the ligand-bound receptor, and may control the activation of caspases 8 and 10.


go_id: GO:0031265
term: CD95 death-inducing signaling complex
ontology: CC
definition:
A protein complex formed upon binding of Fas/CD95/APO-1 to its ligand. The complex includes FADD/Mort1, procaspase-8/10 and c-FLIP in addition to the ligand-bound receptor.


go_id: GO:0031266
term: TRAIL death-inducing signaling complex
ontology: CC
definition:
A protein complex formed upon binding of TRAIL to its ligand. The complex includes FADD/Mort1 and procaspase-8 addition to the ligand-bound receptor.


go_id: GO:0031268
term: pseudopodium organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pseudopodium, a temporary protrusion or retractile process of a cell, associated with cellular movement.


go_id: GO:0031273
term: negative regulation of pseudopodium assembly
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of pseudopodia.


go_id: GO:0031274
term: positive regulation of pseudopodium assembly
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the assembly of pseudopodia.


go_id: GO:0031278
term: alpha-1,2-galactosyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a galactose residue from a donor molecule, such as GDP-galactose or UDP-galactose, to an oligosaccharide, forming an alpha-1,2-linkage.


go_id: GO:0031283
term: negative regulation of guanylate cyclase activity
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of guanylate cyclase activity.


go_id: GO:0031284
term: positive regulation of guanylate cyclase activity
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of guanylate cyclase activity.


go_id: GO:0031285
term: regulation of sorocarp stalk cell differentiation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.


go_id: GO:0031286
term: negative regulation of sorocarp stalk cell differentiation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.


go_id: GO:0031287
term: positive regulation of sorocarp stalk cell differentiation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of sorocarp stalk cell differentiation. An example of this process is found in Dictyostelium discoideum.


go_id: GO:0031288
term: sorocarp morphogenesis
ontology: BP
definition:
The process in which the sorocarp is generated and organized. An example of this process is found in Dictyostelium discoideum.


go_id: GO:0031290
term: retinal ganglion cell axon guidance
ontology: BP
definition:
The process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.


go_id: GO:0031291
term: Ran protein signal transduction
ontology: BP
definition:
The series of molecular signals within the cell that are mediated by a member of the Ran family of proteins switching to a GTP-bound active state.


go_id: GO:0031293
term: membrane protein intracellular domain proteolysis
ontology: BP
definition:
The proteolytic cleavage of a transmembrane protein leading to the release of an intracellular domain.


go_id: GO:0031294
term: lymphocyte costimulation
ontology: BP
definition:
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B- or T cell receptor to augment B- or T cell activation.


go_id: GO:0031295
term: T cell costimulation
ontology: BP
definition:
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment T cell activation.


go_id: GO:0031296
term: B cell costimulation
ontology: BP
definition:
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the B cell receptor to augment B cell activation.


go_id: GO:0031297
term: replication fork processing
ontology: BP
definition:
The process in which a DNA replication fork that has stalled is restored to a functional state and replication is restarted. The stalling may be due to DNA damage, DNA secondary structure, bound proteins, dNTP shortage, or other causes.


go_id: GO:0031298
term: replication fork protection complex
ontology: CC
definition:
A protein complex conserved in eukaryotes and associated with the replication fork; the complex stabilizes stalled replication forks and is thought to be involved in coordinating leading- and lagging-strand synthesis and in replication checkpoint signaling.


go_id: GO:0031300
term: intrinsic component of organelle membrane
ontology: CC
definition:
The component of the organelle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031301
term: integral component of organelle membrane
ontology: CC
definition:
The component of the organelle membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031302
term: intrinsic component of endosome membrane
ontology: CC
definition:
The component of the endosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031303
term: integral component of endosome membrane
ontology: CC
definition:
The component of the endosome membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031304
term: intrinsic component of mitochondrial inner membrane
ontology: CC
definition:
The component of the mitochondrial inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031305
term: integral component of mitochondrial inner membrane
ontology: CC
definition:
The component of the mitochondrial inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031306
term: intrinsic component of mitochondrial outer membrane
ontology: CC
definition:
The component of the mitochondrial outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031307
term: integral component of mitochondrial outer membrane
ontology: CC
definition:
The component of the mitochondrial outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031308
term: intrinsic component of nuclear outer membrane
ontology: CC
definition:
The component of the nuclear outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031309
term: integral component of nuclear outer membrane
ontology: CC
definition:
The component of the nuclear outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031310
term: intrinsic component of vacuolar membrane
ontology: CC
definition:
The component of the vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031311
term: intrinsic component of contractile vacuolar membrane
ontology: CC
definition:
The component of the contractile vacuolar membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031312
term: extrinsic component of organelle membrane
ontology: CC
definition:
The component of an organelle membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0031313
term: extrinsic component of endosome membrane
ontology: CC
definition:
The component of an endosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0031314
term: extrinsic component of mitochondrial inner membrane
ontology: CC
definition:
The component of mitochondrial inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0031315
term: extrinsic component of mitochondrial outer membrane
ontology: CC
definition:
The component of a mitochondrial outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0031316
term: extrinsic component of nuclear outer membrane
ontology: CC
definition:
The component of a nuclear outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0031317
term: tripartite ATP-independent periplasmic transporter complex
ontology: CC
definition:
A complex consisting of two membrane proteins and one extracytoplasmic solute receptor. Such transporters transport a variety of substrates without direct ATP power, instead using energy from ion gradients.


go_id: GO:0031318
term: detection of folic acid
ontology: BP
definition:
The series of events in which a folic acid stimulus is received by a cell and converted into a molecular signal.


go_id: GO:0031319
term: detection of cAMP
ontology: BP
definition:
The series of events in which a cAMP (cyclic AMP, adenosine 3',5'-cyclophosphate) stimulus is received by a cell and converted into a molecular signal; cAMP is the nucleotide cyclic AMP.


go_id: GO:0031321
term: ascospore-type prospore assembly
ontology: BP
definition:
During ascospore formation, the process in which each haploid nucleus becomes encapsulated by a double membrane.


go_id: GO:0031322
term: ascospore-type prospore-specific spindle pole body remodeling
ontology: BP
definition:
A spindle pole body (SPB) organization process that takes place during the second meiotic division during ascospore formation and results in the structural reorganization of the SPB; includes the recruitment of sporulation-specific proteins to the outer plaque to form the meiotic outer plaque (MOP).


go_id: GO:0031323
term: regulation of cellular metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.


go_id: GO:0031324
term: negative regulation of cellular metabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.


go_id: GO:0031325
term: positive regulation of cellular metabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways by which individual cells transform chemical substances.


go_id: GO:0031326
term: regulation of cellular biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.


go_id: GO:0031327
term: negative regulation of cellular biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.


go_id: GO:0031328
term: positive regulation of cellular biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of substances, carried out by individual cells.


go_id: GO:0031329
term: regulation of cellular catabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.


go_id: GO:0031330
term: negative regulation of cellular catabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.


go_id: GO:0031331
term: positive regulation of cellular catabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances, carried out by individual cells.


go_id: GO:0031332
term: RNAi effector complex
ontology: CC
definition:
Any protein complex that mediates the effects of small interfering RNAs on gene expression. Most known examples contain one or more members of the Argonaute family of proteins.


go_id: GO:0031333
term: negative regulation of protein-containing complex assembly
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of protein complex assembly.


go_id: GO:0031335
term: regulation of sulfur amino acid metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids.


go_id: GO:0031336
term: negative regulation of sulfur amino acid metabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids.


go_id: GO:0031337
term: positive regulation of sulfur amino acid metabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving sulfur amino acids.


go_id: GO:0031341
term: regulation of cell killing
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of cell killing, the process in which a cell brings about the death of another cell, either in the same or a different organism.


go_id: GO:0031344
term: regulation of cell projection organization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.


go_id: GO:0031345
term: negative regulation of cell projection organization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.


go_id: GO:0031346
term: positive regulation of cell projection organization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the process involved in the formation, arrangement of constituent parts, or disassembly of cell projections.


go_id: GO:0031350
term: intrinsic component of plastid membrane
ontology: CC
definition:
The component of the plastid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031351
term: integral component of plastid membrane
ontology: CC
definition:
The component of the plastid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031352
term: intrinsic component of plastid inner membrane
ontology: CC
definition:
The component of the plastid inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031353
term: integral component of plastid inner membrane
ontology: CC
definition:
The component of the plastid inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031354
term: intrinsic component of plastid outer membrane
ontology: CC
definition:
The component of the plastid outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031355
term: integral component of plastid outer membrane
ontology: CC
definition:
The component of the plastid outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031356
term: intrinsic component of chloroplast inner membrane
ontology: CC
definition:
The component of the chloroplast inner membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031357
term: integral component of chloroplast inner membrane
ontology: CC
definition:
The component of the chloroplast inner membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031358
term: intrinsic component of chloroplast outer membrane
ontology: CC
definition:
The component of the chloroplast outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031359
term: integral component of chloroplast outer membrane
ontology: CC
definition:
The component of the chloroplast outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031360
term: intrinsic component of thylakoid membrane
ontology: CC
definition:
The component of the thylakoid membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0031361
term: integral component of thylakoid membrane
ontology: CC
definition:
The component of the thylakoid membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0031362
term: anchored component of external side of plasma membrane
ontology: CC
definition:
The component of the plasma membrane consisting of the gene products that are tethered to the external side of the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.


go_id: GO:0031364
term: N-terminal protein amino acid deamination, from side chain
ontology: BP
definition:
The removal of an amino group from the side chain of an N-terminal asparagine or glutamine residue of a protein.


go_id: GO:0031369
term: translation initiation factor binding
ontology: MF
definition:
Binding to a translation initiation factor, any polypeptide factor involved in the initiation of ribosome-mediated translation.


go_id: GO:0031370
term: eukaryotic initiation factor 4G binding
ontology: MF
definition:
Binding to eukaryotic initiation factor 4G, a polypeptide factor involved in the initiation of ribosome-mediated translation.


go_id: GO:0031372
term: UBC13-MMS2 complex
ontology: CC
definition:
A heterodimeric ubiquitin conjugating enzyme complex that catalyzes assembly of K63-linked polyubiquitin chains, which act as a signal to promote error-free DNA postreplication repair; in Saccharomyces the complex comprises Ubc13p and Mms2p.


go_id: GO:0031380
term: nuclear RNA-directed RNA polymerase complex
ontology: CC
definition:
A complex required for RNAi mediated heterochromatin assembly. In S. pombe this contains RNA-directed RNA polymerase, a putative helicase and a protein containing a pap25 associated domain.


go_id: GO:0031381
term: viral RNA-directed RNA polymerase complex
ontology: CC
definition:
A virus-specific protein complex that possesses RNA-dependent RNA polymerase activity and replicates the genome of an RNA virus.


go_id: GO:0031382
term: mating projection formation
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a cell projection in response to mating pheromone. This process is observed in unicellular fungi.


go_id: GO:0031383
term: regulation of mating projection assembly
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of mating projection formation by unicellular fungi.


go_id: GO:0031384
term: regulation of initiation of mating projection growth
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of the start of mating projection formation by unicellular fungi.


go_id: GO:0031385
term: regulation of termination of mating projection growth
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of the end of mating projection formation by unicellular fungi.


go_id: GO:0031386
term: protein tag
ontology: MF
definition:
A molecular function exhibited by a protein that is covalently attached (AKA tagged or conjugated) to another protein where it acts as a marker, recognized by the cellular apparatus to target the tagged protein for some cellular process such as modification, sequestration, transport or degradation.


go_id: GO:0031387
term: MPF complex
ontology: CC
definition:
A complex consisting of a Cdc2-class (also known as Cdc28) cyclin-dependent kinase and an M-phase cyclin such as S. pombe Cdc13. The MPF complex phosphorylates and activates the anaphase promoting complex (APC).


go_id: GO:0031389
term: Rad17 RFC-like complex
ontology: CC
definition:
A pentameric protein complex related to replication factor C, which loads a trimeric complex of checkpoint proteins (known as the checkpoint clamp or 9-1-1 complex) onto DNA at damage sites; functions in DNA damage cell cycle checkpoints. In Schizosaccharomyces pombe the subunits are known as Rad17, Rfc2, Rfc3, Rfc4, and Rfc5, while in Saccharomyces cerevisiae the subunits are known as Rad24p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.


go_id: GO:0031390
term: Ctf18 RFC-like complex
ontology: CC
definition:
A heptameric complex related to replication factor C, which loads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) onto DNA and plays a vital role in chromosome cohesion. In Saccharomyces the subunits are known as Ctf18p, Rfc2p, Rfc3p, Rfc4p, Rfc5p, Dcc1p, and Ctf8p.


go_id: GO:0031391
term: Elg1 RFC-like complex
ontology: CC
definition:
A pentameric replication factor C (RLC) complex, which unloads the DNA polymerase processivity factor proliferating cell nuclear antigen (PCNA) from chromatin and has roles in telomere length regulation and other aspects of genome stability. In Saccharomyces the subunits are known as Elg1p, Rfc2p, Rfc3p, Rfc4p, and Rfc5p.


go_id: GO:0031392
term: regulation of prostaglandin biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.


go_id: GO:0031393
term: negative regulation of prostaglandin biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.


go_id: GO:0031394
term: positive regulation of prostaglandin biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of prostaglandin.


go_id: GO:0031395
term: bursicon neuropeptide hormone complex
ontology: CC
definition:
A neuropeptide hormone secreted by the central nervous system of insects that stimulates the tanning and sclerotization of the adult cuticle following eclosion. The active hormone consists of an obligate heterodimer of the alpha and beta subunits.


go_id: GO:0031396
term: regulation of protein ubiquitination
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the addition of ubiquitin groups to a protein.


go_id: GO:0031397
term: negative regulation of protein ubiquitination
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of ubiquitin groups to a protein.


go_id: GO:0031398
term: positive regulation of protein ubiquitination
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the addition of ubiquitin groups to a protein.


go_id: GO:0031399
term: regulation of protein modification process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.


go_id: GO:0031400
term: negative regulation of protein modification process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.


go_id: GO:0031401
term: positive regulation of protein modification process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the covalent alteration of one or more amino acid residues within a protein.


go_id: GO:0031406
term: carboxylic acid binding
ontology: MF
definition:
Binding to a carboxylic acid, an organic acid containing one or more carboxyl (COOH) groups or anions (COO-).


go_id: GO:0031407
term: oxylipin metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids.


go_id: GO:0031408
term: oxylipin biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of any oxylipin, any of a group of biologically active compounds formed by oxidative metabolism of polyunsaturated fatty acids.


go_id: GO:0031411
term: gas vesicle
ontology: CC
definition:
An intracellular non-membrane-bounded organelle; a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps. By regulating their relative gas vesicle content, aquatic microbes are able to perform vertical migrations.


go_id: GO:0031412
term: gas vesicle organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a gas vesicle. A gas vesicle is a hollow structure made of protein, which usually has the form of a cylindrical tube closed by conical end caps.


go_id: GO:0031413
term: regulation of buoyancy
ontology: BP
definition:
Any process that modulates an organism's tendency or ability to rise or float in a fluid medium such as water or air, often through the use of stored gases.


go_id: GO:0031414
term: N-terminal protein acetyltransferase complex
ontology: CC
definition:
A complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule.


go_id: GO:0031415
term: NatA complex
ontology: CC
definition:
A conserved complex that catalyzes the transfer of an acetyl group to an N-terminal Ser, Ala, Gly, or Thr residue of a protein acceptor molecule. In Saccharomyces the complex includes Nat1p and Ard1p, and may contain additional proteins.


go_id: GO:0031416
term: NatB complex
ontology: CC
definition:
A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Glu, Met-Asp, Met-Asn, or Met-Met N-terminus. In Saccharomyces the complex includes Nat3p and Mdm20p.


go_id: GO:0031417
term: NatC complex
ontology: CC
definition:
A conserved complex that catalyzes the transfer of an acetyl group to the N-terminal residue of a protein acceptor molecule that has a Met-Ile, Met-Leu, Met-Trp, or Met-Phe N-terminus. In Saccharomyces the complex includes Mak3p, Mak10p, and Mak31p.


go_id: GO:0031418
term: L-ascorbic acid binding
ontology: MF
definition:
Binding to L-ascorbic acid, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate; L-ascorbic acid is vitamin C and has co-factor and anti-oxidant activities in many species.


go_id: GO:0031419
term: cobalamin binding
ontology: MF
definition:
Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom.


go_id: GO:0031420
term: alkali metal ion binding
ontology: MF
definition:
Binding to an alkali metal ion; alkali metals are those elements in group Ia of the periodic table, with the exception of hydrogen.


go_id: GO:0031421
term: invertasome
ontology: CC
definition:
A complex formed by a recombinase, a regulatory protein, and the DNA sequences bound by each protein; catalyzes a reversible site-specific recombination reaction that results in the alternate expression of one or more genes in various contexts.


go_id: GO:0031422
term: RecQ family helicase-topoisomerase III complex
ontology: CC
definition:
A complex containing a RecQ family helicase and a topoisomerase III homologue (a member of the topoisomerase type IA subfamily); may also include one or more additional proteins; conserved from E. coli to human.


go_id: GO:0031424
term: keratinization
ontology: BP
definition:
The process in which the cytoplasm of the outermost cells of the vertebrate epidermis is replaced by keratin. Keratinization occurs in the stratum corneum, feathers, hair, claws, nails, hooves, and horns.


go_id: GO:0031425
term: chloroplast RNA processing
ontology: BP
definition:
The conversion of a primary RNA molecule transcribed from a chloroplast genome into one or more mature RNA molecules.


go_id: GO:0031426
term: polycistronic mRNA processing
ontology: BP
definition:
The conversion of a primary mRNA transcript containing more than one complete protein-coding region into individual mature mRNA molecules.


go_id: GO:0031427
term: response to methotrexate
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methotrexate stimulus. Methotrexate is 4-amino-10-methylformic acid, a folic acid analogue that is a potent competitive inhibitor of dihydrofolate reductase.


go_id: GO:0031428
term: box C/D RNP complex
ontology: CC
definition:
A ribonucleoprotein complex containing a box C/D type RNA that can carry out ribose-2'-O-methylation of target RNAs. Box C/D type RNAs are widespread in eukaryotes and in Archaea, suggesting that an RNA-based guide mechanism for directing specific RNA 2'-O-ribose methylations was present in the common ancestor of Archaea and Eukarya.


go_id: GO:0031430
term: M band
ontology: CC
definition:
The midline of aligned thick filaments in a sarcomere; location of specific proteins that link thick filaments. Depending on muscle type the M band consists of different numbers of M lines.


go_id: GO:0031431
term: Dbf4-dependent protein kinase complex
ontology: CC
definition:
A heterodimeric protein complex required for the activation of DNA replication origins; comprises a catalytic subunit and a regulatory subunit (in Saccharomyces, Cdc7p and Dbf4p, respectively); complexes identified in other species generally contain proteins related to the Saccharomyces proteins.


go_id: GO:0031432
term: titin binding
ontology: MF
definition:
Binding to titin, any of a family of giant proteins found in striated and smooth muscle. In striated muscle, single titin molecules span half the sarcomere, with their N- and C-termini in the Z-disc and M-line, respectively.


go_id: GO:0031433
term: telethonin binding
ontology: MF
definition:
Binding to telethonin, a protein found in the Z disc of striated muscle and which is a substrate of the titin kinase.


go_id: GO:0031434
term: mitogen-activated protein kinase kinase binding
ontology: MF
definition:
Binding to a mitogen-activated protein kinase kinase, a protein that can phosphorylate a MAP kinase.


go_id: GO:0031435
term: mitogen-activated protein kinase kinase kinase binding
ontology: MF
definition:
Binding to a mitogen-activated protein kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase.


go_id: GO:0031436
term: BRCA1-BARD1 complex
ontology: CC
definition:
A heterodimeric complex comprising BRCA1 and BARD1, which possesses ubiquitin ligase activity and is involved in genome maintenance, possibly by functioning in surveillance for DNA damage.


go_id: GO:0031437
term: regulation of mRNA cleavage
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of mRNA cleavage, any process in which a pre-mRNA or mRNA molecule is cleaved at specific sites or in a regulated manner.


go_id: GO:0031440
term: regulation of mRNA 3'-end processing
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of mRNA 3'-end processing, any process involved in forming the mature 3' end of an mRNA molecule.


go_id: GO:0031441
term: negative regulation of mRNA 3'-end processing
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of mRNA 3'-end processing.


go_id: GO:0031443
term: fast-twitch skeletal muscle fiber contraction
ontology: BP
definition:
A process in which force is generated within fast-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The fast-twitch skeletal muscle is characterized by fast time parameters, high force development and fatiguability.


go_id: GO:0031444
term: slow-twitch skeletal muscle fiber contraction
ontology: BP
definition:
A process in which force is generated within slow-twitch skeletal muscle tissue, resulting in a change in muscle geometry. Force generation involves a chemo-mechanical energy conversion step that is carried out by the actin/myosin complex activity, which generates force through ATP hydrolysis. The slow-twitch skeletal muscle is characterized by slow time parameters, low force development and resistance to fatigue.


go_id: GO:0031446
term: regulation of fast-twitch skeletal muscle fiber contraction
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of fast-twitch skeletal muscle contraction.


go_id: GO:0031447
term: negative regulation of fast-twitch skeletal muscle fiber contraction
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of fast-twitch skeletal muscle contraction.


go_id: GO:0031448
term: positive regulation of fast-twitch skeletal muscle fiber contraction
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of fast-twitch skeletal muscle contraction.


go_id: GO:0031449
term: regulation of slow-twitch skeletal muscle fiber contraction
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of slow-twitch skeletal muscle contraction.


go_id: GO:0031450
term: negative regulation of slow-twitch skeletal muscle fiber contraction
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of slow-twitch skeletal muscle contraction.


go_id: GO:0031451
term: positive regulation of slow-twitch skeletal muscle fiber contraction
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of slow-twitch skeletal muscle contraction.


go_id: GO:0031452
term: negative regulation of heterochromatin formation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of heterochromatin formation.


go_id: GO:0031456
term: glycine betaine biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of glycine betaine, N-trimethylglycine.


go_id: GO:0031457
term: glycine betaine catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of glycine betaine, N-trimethylglycine.


go_id: GO:0031459
term: ABC-type glycine betaine transporter activity
ontology: MF
definition:
Catalysis of the reaction: ATP + H2O + glycine betaine(out) = ADP + phosphate + glycine betaine(in).


go_id: GO:0031460
term: glycine betaine transport
ontology: BP
definition:
The directed movement of glycine betaine, N-trimethylglycine, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0031461
term: cullin-RING ubiquitin ligase complex
ontology: CC
definition:
Any ubiquitin ligase complex in which the catalytic core consists of a member of the cullin family and a RING domain protein; the core is associated with one or more additional proteins that confer substrate specificity.


go_id: GO:0031462
term: Cul2-RING ubiquitin ligase complex
ontology: CC
definition:
A ubiquitin ligase complex in which a cullin from the Cul2 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.


go_id: GO:0031463
term: Cul3-RING ubiquitin ligase complex
ontology: CC
definition:
A ubiquitin ligase complex in which a cullin from the Cul3 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a BTB-domain-containing protein.


go_id: GO:0031464
term: Cul4A-RING E3 ubiquitin ligase complex
ontology: CC
definition:
A ubiquitin ligase complex in which a cullin from the Cul4A subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an adaptor protein.


go_id: GO:0031465
term: Cul4B-RING E3 ubiquitin ligase complex
ontology: CC
definition:
A ubiquitin ligase complex in which a cullin from the Cul4B subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by unknown subunits.


go_id: GO:0031466
term: Cul5-RING ubiquitin ligase complex
ontology: CC
definition:
A ubiquitin ligase complex in which a cullin from the Cul5 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by an elongin-BC adaptor and a SOCS/BC box protein.


go_id: GO:0031467
term: Cul7-RING ubiquitin ligase complex
ontology: CC
definition:
A ubiquitin ligase complex in which a cullin from the Cul7 subfamily and a RING domain protein form the catalytic core; substrate specificity is conferred by a Skp1 linker and an F-box protein.


go_id: GO:0031468
term: nuclear membrane reassembly
ontology: BP
definition:
The reformation of the nuclear membranes following their breakdown in the context of a normal process.


go_id: GO:0031469
term: bacterial microcompartment
ontology: CC
definition:
An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.


go_id: GO:0031470
term: carboxysome
ontology: CC
definition:
An organelle consisting of a proteinaceous coat and enzymes for the fixation of CO(2). It augments the concentration of CO(2) in the vicinity of RuBisCO to increase the efficiency of CO(2) fixation under atmospheric conditions.


go_id: GO:0031471
term: ethanolamine degradation polyhedral organelle
ontology: CC
definition:
An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of ethanolamine whose purpose is the protection of the rest of the cell from the toxic acetaldehyde product of the enzyme ethanolamine ammonia lyase.


go_id: GO:0031472
term: propanediol degradation polyhedral organelle
ontology: CC
definition:
An organelle found in bacteria consisting of a proteinaceous coat containing enzymes for the degradation of 1,2-propanediol whose purpose is the protection of the rest of the cell from the toxic propionaldehyde product of the enzyme diol dehydratase.


go_id: GO:0031474
term: myosin IV complex
ontology: CC
definition:
A myosin complex containing one or more class IV myosin heavy chains and associated light chains; myosin IV is relatively uncharacterized, but is predicted to have a single motor domain, one IQ motif and a tail with a Myosin Tail Homology (myTH4) domain homologous to that in the tails of myosins VII and XV.


go_id: GO:0031475
term: myosin V complex
ontology: CC
definition:
A myosin complex containing a dimer of class V myosin heavy chains and associated light chains; involved in intracellular transport. Myosin V is a dimeric molecule consisting of conserved motor domains followed by 6 IQ motifs which bind specific light chains and calmodulin. The tail domain is important for cellular localization and cargo binding and can be divided into an alpha-helical coiled coil region and a C-terminal globular region.


go_id: GO:0031476
term: myosin VI complex
ontology: CC
definition:
A myosin complex containing one or more class VI myosin heavy chains and associated light chains. Myosin VI has a single IQ motif in the neck and a tail region with a coiled coil domain followed by a unique globular domain; a unique insertion that enables myosin VI to move towards the pointed or minus end of actin filaments.


go_id: GO:0031477
term: myosin VII complex
ontology: CC
definition:
A myosin complex containing a dimer of class VII myosin heavy chains and associated light chains. Myosin VII (240 kDa) is predicted to be a dimeric molecule with 5 IQ motifs and a tail region with a short stretch of coiled coil followed by two myosin-tail homology (MyTH4) domains, two talin-binding (FERM) domains and an SH3-domain.


go_id: GO:0031478
term: myosin VIII complex
ontology: CC
definition:
A myosin complex containing a dimer of class VIII myosin heavy chains and associated light chains. Myosin VIII is predicted to be dimeric, and contain an unusual 100-190 residue N-terminal extension prior to their motor domains, 3-4 IQ motifs, a short region (~70 residues) of predicted alpha-helical coiled coil and a C-terminal domain.


go_id: GO:0031479
term: myosin IX complex
ontology: CC
definition:
A myosin complex containing a class IX myosin heavy chain and associated light chains. Myosin IX is monomeric with a motor domain containing an N-terminal extension and an insert in the actin binding interface, followed by four to six IQ motifs and a tail region that contains a zinc binding motif and a domain with homology to GTPase activating proteins (GAPs) of the Rho family of G-proteins.


go_id: GO:0031481
term: myosin XI complex
ontology: CC
definition:
A myosin complex containing a dimer of class XI myosin heavy chains and associated light chains. Myosin XI heavy chain sizes are similar in molecular structure to the class V myosins with 5 to 6 IQ motifs and tail regions with predicted coiled coil domains (forming dimeric molecules) and large C-terminal regions.


go_id: GO:0031482
term: myosin XII complex
ontology: CC
definition:
A myosin complex containing one or more class XII myosin heavy chains and associated light chains; myosin XII contains a large tail region with two MyTH4 domains and a short region of coiled coil.


go_id: GO:0031484
term: myosin XIV complex
ontology: CC
definition:
A myosin complex containing a class XIV myosin heavy chain and associated light chains; myosin XIV heavy chains are the simplest known, containing a motor domain, no classic IQ motif and variable length tails.


go_id: GO:0031485
term: myosin XV complex
ontology: CC
definition:
A myosin complex containing a class XV myosin heavy chain and associated light chains. Myosin XV is single headed, and has a large extension (1200aa) at the N-terminus of the motor domain, two IQ motifs and a tail with a similar domain structure to that of the tail of myosin VII.


go_id: GO:0031486
term: myosin XVI complex
ontology: CC
definition:
A myosin complex containing a class XVI myosin heavy chains and associated light chains; myosin XVI heavy chains contain ankyrin repeat.


go_id: GO:0031488
term: myosin XVIII complex
ontology: CC
definition:
A myosin complex containing a class XVIII myosin heavy chain and associated light chains; myosin XVIII heavy chains contain an N-terminal PDZ domain.


go_id: GO:0031491
term: nucleosome binding
ontology: MF
definition:
Binding to a nucleosome, a complex comprised of DNA wound around a multisubunit core and associated proteins, which forms the primary packing unit of DNA into higher order structures.


go_id: GO:0031494
term: regulation of mating type switching
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of mating type switching, the conversion of a single-cell organism from one mating type to another by the precise replacement of a DNA sequence at the expressed mating type locus with a copy of a sequence from a donor locus.


go_id: GO:0031495
term: negative regulation of mating type switching
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of mating type switching.


go_id: GO:0031499
term: TRAMP complex
ontology: CC
definition:
A multiprotein complex having distributive polyadenylation activity of a variety of RNA substrates including hypomodified and incorrectly folded tRNAs, pre-snRNAs, pre-snoRNAs, incorrectly spliced or processed pre-mRNAs, cryptic unstable transcripts (CUTs), pre-rRNAs and rRNA fragments released as part of rRNA processing. In S. cerevisiae, the complex consists of either Pap2 (also known as Trf4) or Trf5, Air1 or Air2, and Mtr4, and is involved in RNA 3'-end processing and in RNA surveillance and quality control.


go_id: GO:0031500
term: Tea1 cell-end complex
ontology: CC
definition:
A high molecular weight complex characterized in S. pombe containing the cell-end anchoring protein Tea1. This complex is transported to the cell ends by microtubules and is involved in bipolar growth and the maintennce of normal cell polarity.


go_id: GO:0031502
term: dolichyl-phosphate-mannose-protein mannosyltransferase complex
ontology: CC
definition:
A complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity; usually includes members of the PMT1 and PMT2 protein subfamilies.


go_id: GO:0031503
term: protein-containing complex localization
ontology: BP
definition:
A localization process that acts on a protein complex; the complex is transported to, or maintained in, a specific location.


go_id: GO:0031504
term: peptidoglycan-based cell wall organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the peptidoglycan-based cell wall.


go_id: GO:0031505
term: fungal-type cell wall organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the fungal-type cell wall.


go_id: GO:0031506
term: cell wall glycoprotein biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of cell wall glycoproteins, any cell wall protein that contains covalently bound sugar residues.


go_id: GO:0031507
term: heterochromatin formation
ontology: BP
definition:
An epigenetic gene silencing mechanism in which chromatin is compacted into heterochromatin, resulting in a chromatin conformation refractory to transcription. This process starts with heterochromatin nucleation, its spreading, and ends with heterochromatin boundary formation.


go_id: GO:0031508
term: pericentric heterochromatin formation
ontology: BP
definition:
The compaction of chromatin located adjacent to the CENP-A rich centromere 'central core' and characterized by methylation of histone H3K9, into heterochromatin, resulting in the repression of transcription at pericentric DNA.


go_id: GO:0031511
term: Mis6-Sim4 complex
ontology: CC
definition:
A protein complex that forms part of the inner kinetochore, which is involved in the loading of the centromeric histone h3 variant CENP-A onto centromeres and in centromere specific heterochromatin formation. The complex contains about 12 proteins, of which two are known as Mis6 and Sim4 in S. pombe and CENP-I and CENP-H in human.


go_id: GO:0031514
term: motile cilium
ontology: CC
definition:
A cilium which may have a variable arrangement of axonemal microtubules and also contains molecular motors. It may beat with a whip-like pattern that promotes cell motility or transport of fluids and other cells across a cell surface, such as on epithelial cells that line the lumenal ducts of various tissues; or they may display a distinct twirling motion that directs fluid flow asymmetrically across the cellular surface to affect asymmetric body plan organization. Motile cilia can be found in single as well as multiple copies per cell.


go_id: GO:0031515
term: tRNA (m1A) methyltransferase complex
ontology: CC
definition:
A protein complex involved in the catalysis of the formation of the modified nucleotide 1-methyladenosine (m1A) in tRNA. In yeast, it is a heterotetramer of two subunits, Gcd10p and Gcd14p, while in bacteria and archaea it is a homotetramer.


go_id: GO:0031516
term: far-red light photoreceptor activity
ontology: MF
definition:
The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 730nm. The response may involve a change in conformation.


go_id: GO:0031517
term: red light photoreceptor activity
ontology: MF
definition:
The function of absorbing and responding to electromagnetic radiation with a wavelength of approximately 660nm. The response may involve a change in conformation.


go_id: GO:0031518
term: CBF3 complex
ontology: CC
definition:
A multisubunit protein complex that binds to centromeric DNA and initiates kinetochore assembly. In yeast, this complex consists of four subunits, namely Ctf13p, Skp1p, Cep3p and Cbf2p.


go_id: GO:0031519
term: PcG protein complex
ontology: CC
definition:
A chromatin-associated multiprotein complex containing Polycomb Group proteins. In Drosophila, Polycomb group proteins are involved in the long-term maintenance of gene repression, and PcG protein complexes associate with Polycomb group response elements (PREs) in target genes to regulate higher-order chromatin structure.


go_id: GO:0031521
term: spitzenkorper
ontology: CC
definition:
Structure within the hyphal tip of filamentous fungi that acts as an organizing center for hyphal tip growth; may function to supply vesicles to the elongating tip and/or to organize cytoskeletal microfilaments.


go_id: GO:0031522
term: cell envelope Sec protein transport complex
ontology: CC
definition:
A transmembrane protein complex involved in the translocation of proteins across the cytoplasmic membrane. In Gram-negative bacteria, Sec-translocated proteins are subsequently secreted via the type II, IV, or V secretion systems. Sec complex components include SecA, D, E, F, G, Y and YajC.


go_id: GO:0031523
term: Myb complex
ontology: CC
definition:
A multisubunit complex consisting of Myb and other proteins that regulates site specific DNA replication, gene amplification and transcriptional repression.


go_id: GO:0031524
term: menthol metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol.


go_id: GO:0031525
term: menthol biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of menthol, the monoterpene 2-isopropyl-5-methylcyclohexanol.


go_id: GO:0031529
term: ruffle organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ruffle, a projection at the leading edge of a crawling cell.


go_id: GO:0031530
term: gonadotropin-releasing hormone receptor binding
ontology: MF
definition:
Binding to a receptor for gonadotropin-releasing hormone (GnRH), a peptide hormone that is synthesized and released by the hypothalamus and is responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary.


go_id: GO:0031531
term: thyrotropin-releasing hormone receptor binding
ontology: MF
definition:
Binding to a receptor for thyrotropin-releasing hormone, a tripeptide hormone that is produced by the hypothalamus and stimulates the release of thyroid-stimulating hormone (TSH) and prolactin by the anterior pituitary.


go_id: GO:0031532
term: actin cytoskeleton reorganization
ontology: BP
definition:
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of constituent parts of cytoskeletal structures comprising actin filaments and their associated proteins.


go_id: GO:0031533
term: mRNA cap methyltransferase complex
ontology: CC
definition:
A protein complex that consists of an RNA 5' triphosphatase and a guanyl transferase (Cet1p and Ceg1p in S. cerevisiae; Pct1 and Ceg1 in S. pombe) and is involved in mRNA capping.


go_id: GO:0031534
term: minus-end directed microtubule sliding
ontology: BP
definition:
The movement of one microtubule along another microtubule, where the motion is directed towards the minus ends of the microtubules.


go_id: GO:0031535
term: plus-end directed microtubule sliding
ontology: BP
definition:
The movement of one microtubule along another microtubule, where the motion is directed towards the plus ends of the microtubules.


go_id: GO:0031536
term: positive regulation of exit from mitosis
ontology: BP
definition:
Any process that activates or increases the rate of progression from anaphase/telophase (high mitotic CDK activity) to G1 (low mitotic CDK activity).


go_id: GO:0031537
term: regulation of anthocyanin metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of chemical reactions and pathways involving anthocyanins.


go_id: GO:0031538
term: negative regulation of anthocyanin metabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of chemical reactions and pathways involving anthocyanins.


go_id: GO:0031539
term: positive regulation of anthocyanin metabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of chemical reactions and pathways involving anthocyanins.


go_id: GO:0031540
term: regulation of anthocyanin biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins.


go_id: GO:0031541
term: negative regulation of anthocyanin biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins.


go_id: GO:0031542
term: positive regulation of anthocyanin biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of anthocyanins.


go_id: GO:0031543
term: peptidyl-proline dioxygenase activity
ontology: MF
definition:
Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl hydroxy-L-proline + succinate + CO2.


go_id: GO:0031544
term: peptidyl-proline 3-dioxygenase activity
ontology: MF
definition:
Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-3-hydroxy-L-proline + succinate + CO2.


go_id: GO:0031545
term: peptidyl-proline 4-dioxygenase activity
ontology: MF
definition:
Catalysis of the reaction: peptidyl L-proline + 2-oxoglutarate + O2 = peptidyl trans-4-hydroxy-L-proline + succinate + CO2.


go_id: GO:0031547
term: brain-derived neurotrophic factor receptor signaling pathway
ontology: BP
definition:
The series of molecular signals generated as a consequence of a brain-derived neurotrophic factor receptor binding to one of its physiological ligands.


go_id: GO:0031548
term: regulation of brain-derived neurotrophic factor receptor signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway.


go_id: GO:0031549
term: negative regulation of brain-derived neurotrophic factor receptor signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway.


go_id: GO:0031550
term: positive regulation of brain-derived neurotrophic factor receptor signaling pathway
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of signaling via the brain-derived neurotrophic factor receptor signaling pathway.


go_id: GO:0031551
term: regulation of brain-derived neurotrophic factor-activated receptor activity
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.


go_id: GO:0031552
term: negative regulation of brain-derived neurotrophic factor-activated receptor activity
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.


go_id: GO:0031553
term: positive regulation of brain-derived neurotrophic factor-activated receptor activity
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of brain-derived neurotrophic factor-activated receptor activity.


go_id: GO:0031554
term: regulation of termination of DNA-templated transcription
ontology: BP
definition:
Any process that modulates the frequency, rate, extent, or location of DNA-templated transcription termination, the process in which transcription is completed; the formation of phosphodiester bonds ceases, the RNA-DNA hybrid dissociates, and RNA polymerase releases the DNA.


go_id: GO:0031556
term: transcriptional attenuation by ribosome
ontology: BP
definition:
A type of transcriptional regulation at the level of early termination. This process can occur only in prokaryotes, where transcription of an operon into messenger RNA and translation of that mRNA into polypeptides occur simultaneously. The general principle is that alternative mRNA secondary structures occur under different physiological conditions such as available amount of a particular amino acid. One set of conditions favors early termination of transcription. In the classic example of the trp biosynthesis operon, translation of the gene for a short, trp-containing polypeptide called the trp operon leader peptide pauses either at a trp codon (if tryptophan is scarce) or the stop codon (if trp is readily available). In the former situation transcription continues, but in the latter a Rho-independent terminator forms and reduces, or attenuates, expression of the tryptophan biosynthesis genes. Although the polypeptides encoded by leader peptide genes appear not to be stable once their translation is complete, it is suggested by recent studies that their nascent polypeptide chains interact specifically with ribosomes, specific uncharged tRNAs, or other cellular components to inhibit release at the stop codon and improve the function of transcriptional attenuation as a regulatory switch.


go_id: GO:0031560
term: cellular bud neck polarisome
ontology: CC
definition:
Protein complex that has a role in determining cell polarity, found at the neck of a fungal bud before and during cytokinesis.


go_id: GO:0031561
term: cellular bud tip polarisome
ontology: CC
definition:
Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal bud.


go_id: GO:0031562
term: hyphal tip polarisome
ontology: CC
definition:
Protein complex that has a role in determining cell polarity, found at the tip of a growing fungal hypha.


go_id: GO:0031563
term: mating projection tip polarisome
ontology: CC
definition:
Protein complex that has a role in determining cell polarity, found at the tip of the mating projection in unicellular fungi exposed to mating pheromone.


go_id: GO:0031564
term: transcription antitermination
ontology: BP
definition:
Regulation of transcription by a mechanism that allows RNA polymerase to continue transcription beyond termination site(s).


go_id: GO:0031566
term: actomyosin contractile ring maintenance
ontology: BP
definition:
The cell cycle process in which the contractile ring is maintained in response to the cytokinesis checkpoint; that is when cytokinesis is delayed awaiting completion of nuclear division or the correct formation of cytokinetic structures. This process occurs in the context of cytokinesis that takes place as part of a cell cycle.


go_id: GO:0031568
term: mitotic G1 cell size control checkpoint signaling
ontology: BP
definition:
A signal transduction process that contributes to a cell size control checkpoint during the G1/S transition of the cell cycle.


go_id: GO:0031569
term: mitotic G2 cell size control checkpoint signaling
ontology: BP
definition:
A signal transduction process that contributes to a cell size control checkpoint prior to the G2/M transition of mitosis.


go_id: GO:0031570
term: DNA integrity checkpoint signaling
ontology: BP
definition:
A signaling process that controls cell cycle progression in response to changes in DNA structure by monitoring the integrity of the DNA. The DNA integrity checkpoint begins with detection of DNA damage, defects in DNA structure or DNA replication, and progresses through signal transduction and ends with cell cycle effector processes.


go_id: GO:0031571
term: mitotic G1 DNA damage checkpoint signaling
ontology: BP
definition:
A signal transduction process that contributes to a mitotic cell cycle G1/S transition DNA damage checkpoint.


go_id: GO:0031573
term: mitotic intra-S DNA damage checkpoint signaling
ontology: BP
definition:
A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.


go_id: GO:0031577
term: spindle checkpoint signaling
ontology: BP
definition:
A signaling process that that controls a cell cycle checkpoint that originates from the mitotic or meiotic spindle.


go_id: GO:0031578
term: mitotic spindle orientation checkpoint signaling
ontology: BP
definition:
A signaling process that monitors and signals errors in the placement or orientation of the spindle in the cell. This delays the completion of anaphase until errors are corrected.


go_id: GO:0031579
term: membrane raft organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of membrane rafts, small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.


go_id: GO:0031581
term: hemidesmosome assembly
ontology: BP
definition:
Assembly of hemidesmosomes, integrin-containing protein complexes that bind to laminin in the basal lamina. Hemidesmosomes form the contact between the basal surface of epithelial cells and the underlying basal lamina.


go_id: GO:0031582
term: replication fork arrest at rDNA repeats
ontology: BP
definition:
A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic rDNA repeat spacer.


go_id: GO:0031583
term: phospholipase D-activating G protein-coupled receptor signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway in which the signal is transmitted via the  activation of phospholipase D (PLD) and a subsequent increase in the intracellular concentration of phosphatidic acid (PA).


go_id: GO:0031585
term: regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.


go_id: GO:0031586
term: negative regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.


go_id: GO:0031587
term: positive regulation of inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the activity of the inositol 1,4,5-trisphosphate-sensitive calcium-release channel.


go_id: GO:0031588
term: nucleotide-activated protein kinase complex
ontology: CC
definition:
A protein complex that possesses nucleotide-dependent protein kinase activity. The nucleotide can be AMP (in S. pombe and human) or ADP (in S. cerevisiae).


go_id: GO:0031590
term: wybutosine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules.


go_id: GO:0031591
term: wybutosine biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of wybutosine, 3H-imidazo[1,2-alpha]purine-7-butanoic acid, 4,9-dihydro- alpha-[(methoxycarbonyl)amino]- 4,6-dimethyl-9-oxo- 3-beta-D-ribofuranosyl methyl ester, a modified nucleoside found in some tRNA molecules.


go_id: GO:0031592
term: centrosomal corona
ontology: CC
definition:
An amorphous structure surrounding the core of the centrosome, from which microtubules are nucleated; contains gamma-tubulin.


go_id: GO:0031594
term: neuromuscular junction
ontology: CC
definition:
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential.


go_id: GO:0031600
term: cytosolic proteasome regulatory particle
ontology: CC
definition:
A multisubunit complex located in the cytosol of a cell, which caps one or both ends of the proteasome core complex. This complex recognizes, unfolds ubiquitinated proteins and translocates them to the proteasome core complex.


go_id: GO:0031604
term: nuclear proteasome core complex, alpha-subunit complex
ontology: CC
definition:
The subunits forming the outer ring of the core complex of a proteasome located in the nucleus of a cell.


go_id: GO:0031606
term: cytosolic proteasome core complex, alpha-subunit complex
ontology: CC
definition:
The proteasome core subcomplex that constitutes the two outer rings of the cytosolic proteasome core complex.


go_id: GO:0031607
term: nuclear proteasome core complex, beta-subunit complex
ontology: CC
definition:
The subunits forming the inner ring of the core complex of a proteasome located in the nucleus of a cell.


go_id: GO:0031609
term: cytosolic proteasome core complex, beta-subunit complex
ontology: CC
definition:
The proteasome core subcomplex that constitutes the two inner rings of the cytosolic proteasome core complex.


go_id: GO:0031610
term: nuclear proteasome regulatory particle, base subcomplex
ontology: CC
definition:
The subunits of the regulatory particle that directly associate with the core complex of a proteasome located in the nucleus of a cell.


go_id: GO:0031612
term: cytosolic proteasome regulatory particle, base subcomplex
ontology: CC
definition:
The subcomplex of the proteasome regulatory particle that directly associates with the proteasome core complex located in the cytosol of the cell.


go_id: GO:0031613
term: nuclear proteasome regulatory particle, lid subcomplex
ontology: CC
definition:
The subunits that form the peripheral lid of the regulatory particle of a proteasome located in the nucleus of a cell.


go_id: GO:0031615
term: cytosolic proteasome regulatory particle, lid subcomplex
ontology: CC
definition:
The subcomplex of the cytosolic proteasome regulatory particle that forms the peripheral lid, which is added on top of the base subcomplex.


go_id: GO:0031617
term: NMS complex
ontology: CC
definition:
A supercomplex formed by the association of two subcomplexes (known as MIND and Ndc80 in Schizosaccharomyces) with additional proteins at the kinetochores of condensed nuclear chromosomes.


go_id: GO:0031619
term: homologous chromosome orientation involved in meiotic metaphase I plate congression
ontology: BP
definition:
The cell cycle process in which the sister centromeres of one chromosome attach to microtubules that emanate from the same spindle pole, which ensures that homologous maternal and paternal chromosomes are pulled in opposite directions at anaphase of meiosis I.


go_id: GO:0031623
term: receptor internalization
ontology: BP
definition:
A receptor-mediated endocytosis process that results in the movement of receptors from the plasma membrane to the inside of the cell. The process begins when cell surface receptors are monoubiquitinated following ligand-induced activation. Receptors are subsequently taken up into endocytic vesicles from where they are either targeted to the lysosome or vacuole for degradation or recycled back to the plasma membrane.


go_id: GO:0031627
term: telomeric loop formation
ontology: BP
definition:
The process in which linear telomeric DNA is remodeled into duplex loops, by the invasion of a 3' single-stranded overhang into the duplex region.


go_id: GO:0031629
term: synaptic vesicle fusion to presynaptic active zone membrane
ontology: BP
definition:
Fusion of the membrane of a synaptic vesicle with the presynaptic active zone membrane, thereby releasing its cargo neurotransmitters into the synaptic cleft.


go_id: GO:0031630
term: regulation of synaptic vesicle fusion to presynaptic active zone membrane
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.


go_id: GO:0031631
term: negative regulation of synaptic vesicle fusion to presynaptic active zone membrane
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.


go_id: GO:0031632
term: positive regulation of synaptic vesicle fusion to presynaptic active zone membrane
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of synaptic vesicle fusion to the presynaptic membrane.


go_id: GO:0031635
term: adenylate cyclase-inhibiting opioid receptor signaling pathway
ontology: BP
definition:
An adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor, and ending with the regulation of a downstream cellular process.


go_id: GO:0031637
term: regulation of neuronal synaptic plasticity in response to neurotrophin
ontology: BP
definition:
The process in which a neurotrophic factor induces neuronal synaptic plasticity, the ability of neuronal synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.


go_id: GO:0031639
term: plasminogen activation
ontology: BP
definition:
The process in which inactive plasminogen is processed to active plasmin. This process includes cleavage at an internal Arg-Val site to form an N-terminal A-chain and C-terminal B-chain held together by a disulfide bond, and can include further proteolytic cleavage events to remove the preactivation peptide.


go_id: GO:0031640
term: killing of cells of another organism
ontology: BP
definition:
Any process in an organism that results in the killing of cells of another organism, including in some cases the death of the other organism. Killing here refers to the induction of death in one cell by another cell, not cell-autonomous death due to internal or other environmental conditions.


go_id: GO:0031641
term: regulation of myelination
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the formation of a myelin sheath around nerve axons.


go_id: GO:0031642
term: negative regulation of myelination
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the formation of a myelin sheath around nerve axons.


go_id: GO:0031643
term: positive regulation of myelination
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the formation of a myelin sheath around nerve axons.


go_id: GO:0031644
term: regulation of nervous system process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a neurophysiological process, an organ system process carried out by any of the organs or tissues of the nervous system.


go_id: GO:0031645
term: negative regulation of nervous system process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of a neurophysiological process.


go_id: GO:0031646
term: positive regulation of nervous system process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of a neurophysiological process.


go_id: GO:0031647
term: regulation of protein stability
ontology: BP
definition:
Any process that affects the structure and integrity of a protein, altering the likelihood of its degradation or aggregation.


go_id: GO:0031648
term: protein destabilization
ontology: BP
definition:
Any process that decreases the stability of a protein, making it more vulnerable to degradative processes or aggregation.


go_id: GO:0031649
term: heat generation
ontology: BP
definition:
Any homeostatic process in which an organism produces heat, thereby raising its internal temperature.


go_id: GO:0031653
term: heat dissipation
ontology: BP
definition:
Any homeostatic process in which an organism releases excess heat to the environment, thereby lowering its internal temperature.


go_id: GO:0031663
term: lipopolysaccharide-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of a lipopolysaccharide (LPS) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Lipopolysaccharides are major components of the outer membrane of Gram-negative bacteria, making them prime targets for recognition by the immune system.


go_id: GO:0031664
term: regulation of lipopolysaccharide-mediated signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.


go_id: GO:0031665
term: negative regulation of lipopolysaccharide-mediated signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.


go_id: GO:0031666
term: positive regulation of lipopolysaccharide-mediated signaling pathway
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of signaling in response to detection of lipopolysaccharide.


go_id: GO:0031667
term: response to nutrient levels
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.


go_id: GO:0031668
term: cellular response to extracellular stimulus
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an extracellular stimulus.


go_id: GO:0031669
term: cellular response to nutrient levels
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting the presence, absence, or concentration of nutrients.


go_id: GO:0031670
term: cellular response to nutrient
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nutrient stimulus.


go_id: GO:0031671
term: primary cell septum biogenesis
ontology: BP
definition:
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a primary cell septum following nuclear division.


go_id: GO:0031672
term: A band
ontology: CC
definition:
The dark-staining region of a sarcomere, in which myosin thick filaments are present; the center is traversed by the paler H zone, which in turn contains the M line.


go_id: GO:0031673
term: H zone
ontology: CC
definition:
A relatively pale zone traversing the center of the A band of a sarcomere, visible in relaxed muscle fibers; consists of the central portion of thick (myosin) filaments that are not overlapped by thin (actin) filaments.


go_id: GO:0031674
term: I band
ontology: CC
definition:
A region of a sarcomere that appears as a light band on each side of the Z disc, comprising a region of the sarcomere where thin (actin) filaments are not overlapped by thick (myosin) filaments; contains actin, troponin, and tropomyosin; each sarcomere includes half of an I band at each end.


go_id: GO:0031680
term: G-protein beta/gamma-subunit complex
ontology: CC
definition:
The heterodimer formed by the beta and gamma subunits of a heterotrimeric G protein, which dissociates from the alpha subunit upon guanine nuclotide exchange.


go_id: GO:0031720
term: haptoglobin binding
ontology: MF
definition:
Binding to a haptoglobin, any alpha2 globulin of blood plasma that can combine with free oxyhemoglobin to form a stable complex.


go_id: GO:0031848
term: protection from non-homologous end joining at telomere
ontology: BP
definition:
A process that prevents non-homologous end joining at telomere, thereby ensuring that telomeres do not fuse.


go_id: GO:0031860
term: telomeric 3' overhang formation
ontology: BP
definition:
The formation of the single stranded telomeric 3' overhang, a conserved feature that ranges in length from 12 nt in budding yeast to approximately 500 nt in humans.


go_id: GO:0031897
term: Tic complex
ontology: CC
definition:
The translocon of the inner envelope of chloroplasts, which facilitates the import of proteins across the chloroplast inner membrane.


go_id: GO:0031898
term: chromoplast envelope
ontology: CC
definition:
The double lipid bilayer enclosing the chromoplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.


go_id: GO:0031899
term: chromoplast inner membrane
ontology: CC
definition:
The inner, i.e. lumen-facing, lipid bilayer of the chromoplast envelope; also faces the chromoplast stroma.


go_id: GO:0031912
term: oral apparatus
ontology: CC
definition:
Complex basket- or funnel-like structure used by the cell to collect food and channel it to the cytostome; includes specialized sub-structures made up of closely-spaced cilia and underlying basal bodies and fibrillar systems.


go_id: GO:0031913
term: contractile vacuole pore
ontology: CC
definition:
Stable structure that regulates the flow of liquid between the contractile vacuole and the surrounding medium.


go_id: GO:0031914
term: negative regulation of synaptic plasticity
ontology: BP
definition:
A process that decreases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.


go_id: GO:0031915
term: positive regulation of synaptic plasticity
ontology: BP
definition:
A process that increases synaptic plasticity, the ability of synapses to change as circumstances require. They may alter function, such as increasing or decreasing their sensitivity, or they may increase or decrease in actual numbers.


go_id: GO:0031916
term: regulation of synaptic metaplasticity
ontology: BP
definition:
A process that modulates synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require.


go_id: GO:0031917
term: negative regulation of synaptic metaplasticity
ontology: BP
definition:
A process that decreases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require.


go_id: GO:0031918
term: positive regulation of synaptic metaplasticity
ontology: BP
definition:
A process that increases synaptic metaplasticity. Metaplasticity is a higher-order form of plasticity and is manifest as a change in the ability to induce subsequent synaptic plasticity that is the ability of synapses to change as circumstances require.


go_id: GO:0031919
term: vitamin B6 transport
ontology: BP
definition:
The directed movement of any of the vitamin B6 compounds -- pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate -- into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0031920
term: pyridoxal transport
ontology: BP
definition:
The directed movement of pyridoxal into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.


go_id: GO:0031921
term: pyridoxal phosphate transport
ontology: BP
definition:
The directed movement of pyridoxal phosphate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore; pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6.


go_id: GO:0031922
term: pyridoxamine transport
ontology: BP
definition:
The directed movement of pyridoxamine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.


go_id: GO:0031923
term: pyridoxine transport
ontology: BP
definition:
The directed movement of pyridoxine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.


go_id: GO:0031924
term: vitamin B6 transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of any of the vitamin B6 compounds, pyridoxal, pyridoxamine and pyridoxine and the active form, pyridoxal phosphate, from one side of a membrane to the other.


go_id: GO:0031925
term: pyridoxal transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of pyridoxal from one side of a membrane to the other. Pyridoxal, 3-hydroxy-5-(hydroxymethyl)-2-methyl-4-pyridinecarboxaldehyde, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.


go_id: GO:0031926
term: pyridoxal phosphate transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of pyridoxal phosphate from one side of a membrane to the other. Pyridoxal phosphate is pyridoxal phosphorylated at the hydroxymethyl group of C-5, and is the active form of vitamin B6.


go_id: GO:0031927
term: pyridoxamine transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of pyridoxamine from one side of a membrane to the other. Pyridoxamine, 4-(aminomethyl)-5-(hydroxymethyl)-2-methylpyridin-3-ol, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.


go_id: GO:0031928
term: pyridoxine transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of pyridoxine from one side of a membrane to the other. Pyridoxine, 2-methyl-3-hydroxy-4,5-bis(hydroxymethyl)pyridine, is one of the vitamin B6 compounds. Pyridoxal, pyridoxamine and pyridoxine are collectively known as vitamin B6, and are efficiently converted to the biologically active form of vitamin B6, pyridoxal phosphate.


go_id: GO:0031929
term: TOR signaling
ontology: BP
definition:
The series of molecular signals mediated by TOR (Target of rapamycin) proteins, members of the phosphoinositide (PI) 3-kinase related kinase (PIKK) family that act as serine/threonine kinases in response to nutrient availability or growth factors.


go_id: GO:0031930
term: mitochondria-nucleus signaling pathway
ontology: BP
definition:
The series of molecular signals that forms a pathway of communication from the mitochondria to the nucleus and initiates cellular changes in response to changes in mitochondrial function.


go_id: GO:0031931
term: TORC1 complex
ontology: CC
definition:
A protein complex that contains at least TOR (target of rapamycin) and Raptor (regulatory-associated protein of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of S6K. In Saccharomyces, the complex contains Kog1p, Lst8p, Tco89p, and either Tor1p or Tor2p.


go_id: GO:0031932
term: TORC2 complex
ontology: CC
definition:
A protein complex that contains at least TOR (target of rapamycin) and Rictor (rapamycin-insensitive companion of TOR), or orthologs of, in complex with other signaling components. Mediates the phosphorylation and activation of PKB (also called AKT). In Saccharomyces, the complex contains Avo1p, Avo2p, Tsc11p, Lst8p, Bit61p, Slm1p, Slm2p, and Tor2p.


go_id: GO:0031942
term: i-AAA complex
ontology: CC
definition:
Protease complex of the mitochondrial inner membrane whose catalytic residues lie on the intermembrane space side of the inner membrane; involved in mitochondrial protein turnover. Contains a subunit belonging to the AAA family of ATP-dependent metalloproteases.


go_id: GO:0031943
term: regulation of glucocorticoid metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids.


go_id: GO:0031944
term: negative regulation of glucocorticoid metabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids.


go_id: GO:0031945
term: positive regulation of glucocorticoid metabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving glucocorticoids.


go_id: GO:0031946
term: regulation of glucocorticoid biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.


go_id: GO:0031947
term: negative regulation of glucocorticoid biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.


go_id: GO:0031948
term: positive regulation of glucocorticoid biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of glucocorticoids.


go_id: GO:0031949
term: regulation of glucocorticoid catabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids.


go_id: GO:0031950
term: negative regulation of glucocorticoid catabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids.


go_id: GO:0031951
term: positive regulation of glucocorticoid catabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of glucocorticoids.


go_id: GO:0031952
term: regulation of protein autophosphorylation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of addition of the phosphorylation by a protein of one or more of its own residues.


go_id: GO:0031953
term: negative regulation of protein autophosphorylation
ontology: BP
definition:
Any process that stops, prevents or decreases the rate of the phosphorylation by a protein of one or more of its own residues.


go_id: GO:0031954
term: positive regulation of protein autophosphorylation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the phosphorylation by a protein of one or more of its own residues.


go_id: GO:0031955
term: short-chain fatty acid-CoA ligase activity
ontology: MF
definition:
Catalysis of the reaction: ATP + a short-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; short-chain fatty acids are fatty acids with a chain length of less than C6.


go_id: GO:0031956
term: medium-chain fatty acid-CoA ligase activity
ontology: MF
definition:
Catalysis of the reaction: ATP + a medium-chain carboxylic acid + CoA = AMP + diphosphate + an acyl-CoA; a medium-chain fatty acid is any fatty acid with a chain length of between C6 and C12.


go_id: GO:0031957
term: very long-chain fatty acid-CoA ligase activity
ontology: MF
definition:
Catalysis of the reaction: ATP + a very-long-chain fatty acid + CoA = AMP + diphosphate + an acyl-CoA; a very long-chain fatty acid is a fatty acid which has a chain length greater than C22.


go_id: GO:0031958
term: corticosteroid receptor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by corticosteroid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0031959
term: mineralocorticoid receptor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by mineralocorticoid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0031960
term: response to corticosteroid
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a corticosteroid hormone stimulus. A corticosteroid is a steroid hormone that is produced in the adrenal cortex. Corticosteroids are involved in a wide range of physiologic systems such as stress response, immune response and regulation of inflammation, carbohydrate metabolism, protein catabolism, blood electrolyte levels, and behavior. They include glucocorticoids and mineralocorticoids.


go_id: GO:0031963
term: nuclear cortisol receptor activity
ontology: MF
definition:
Combining with cortisol and transmitting the signal within the cell to trigger a change in cell activity or function.


go_id: GO:0031965
term: nuclear membrane
ontology: CC
definition:
Either of the lipid bilayers that surround the nucleus and form the nuclear envelope; excludes the intermembrane space.


go_id: GO:0031967
term: organelle envelope
ontology: CC
definition:
A double membrane structure enclosing an organelle, including two lipid bilayers and the region between them. In some cases, an organelle envelope may have more than two membranes.


go_id: GO:0031974
term: membrane-enclosed lumen
ontology: CC
definition:
The enclosed volume within a sealed membrane or between two sealed membranes. Encompasses the volume enclosed by the membranes of a particular organelle, e.g. endoplasmic reticulum lumen, or the space between the two lipid bilayers of a double membrane surrounding an organelle, e.g. nuclear envelope lumen.


go_id: GO:0031975
term: envelope
ontology: CC
definition:
A multilayered structure surrounding all or part of a cell; encompasses one or more lipid bilayers, and may include a cell wall layer; also includes the space between layers.


go_id: GO:0031985
term: Golgi cisterna
ontology: CC
definition:
Any of the thin, flattened membrane-bounded compartments that form the central portion of the Golgi complex.


go_id: GO:0031987
term: locomotion involved in locomotory behavior
ontology: BP
definition:
Self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.


go_id: GO:0031989
term: bombesin receptor signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway initiated by a bombesin binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0031990
term: mRNA export from nucleus in response to heat stress
ontology: BP
definition:
The directed movement of mRNA from the nucleus to the cytoplasm during a heat stimulus, a temperature stimulus above the optimal temperature for the organism; in particular, a process that enables an organism withstand exposure to temperatures that would otherwise lethally impair poly(A)+ mRNA-nucleus export.


go_id: GO:0031991
term: regulation of actomyosin contractile ring contraction
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of contraction of the actomyosin ring involved in cytokinesis that takes place as part of a cell cycle.


go_id: GO:0031992
term: energy transducer activity
ontology: MF
definition:
The biological transducer activity that accepts energy and converts it to another form, often by transfer to another molecule within the cell.


go_id: GO:0031993
term: light transducer activity
ontology: MF
definition:
Absorbing energy from one or more photons and transferring their energy to another molecule, usually a protein, within the cell.


go_id: GO:0031997
term: N-terminal myristoylation domain binding
ontology: MF
definition:
Binding to the N-terminus of a protein that has the potential to be, or has been, modified by N-terminal myristoylation. Binding affinity is typically altered by myristoylation; for example, N-terminal myristoylation of HIV Nef increases its affinity for calmodulin.


go_id: GO:0031999
term: negative regulation of fatty acid beta-oxidation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of fatty acid beta-oxidation.


go_id: GO:0032001
term: 1,4-alpha-glucan 6-alpha-glucosyltransferase activity
ontology: MF
definition:
Catalysis of the transfer an alpha-D-glucosyl residue in a (1->4)-alpha-D-glucan to the primary hydroxy group of glucose, free or combined in a (1->4)-alpha-D-glucan.


go_id: GO:0032002
term: interleukin-28 receptor complex
ontology: CC
definition:
A protein complex that binds interleukin-28 and interleukin-29. It is composed of an alpha and a beta receptor subunit (in human IFNLR1/IL28Ralpha & IL10RB) and either Interleukin-28 (IFNL2 or IFNL3) or Interleukin-29 (IFNL1).


go_id: GO:0032005
term: signal transduction involved in positive regulation of conjugation with cellular fusion
ontology: BP
definition:
The series of molecular signals that bring about the relay, amplification or dampening of a signal generated in response to a cue, such as starvation or pheromone exposure, in organisms that undergo conjugation with cellular fusion.


go_id: GO:0032009
term: early phagosome
ontology: CC
definition:
A membrane-bounded intracellular vesicle as initially formed upon the ingestion of particulate material by phagocytosis.


go_id: GO:0032010
term: phagolysosome
ontology: CC
definition:
A membrane-bounded intracellular vesicle formed by maturation of an early phagosome following the ingestion of particulate material by phagocytosis; during maturation, phagosomes acquire markers of late endosomes and lysosomes.


go_id: GO:0032011
term: ARF protein signal transduction
ontology: BP
definition:
The series of molecular signals within the cell that are mediated by a member of the ARF family of proteins switching to a GTP-bound active state.


go_id: GO:0032013
term: negative regulation of ARF protein signal transduction
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of ARF protein signal transduction.


go_id: GO:0032014
term: positive regulation of ARF protein signal transduction
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of ARF protein signal transduction.


go_id: GO:0032016
term: negative regulation of Ran protein signal transduction
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of Ran protein signal transduction.


go_id: GO:0032017
term: positive regulation of Ran protein signal transduction
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of Ran protein signal transduction.


go_id: GO:0032019
term: mitochondrial cloud
ontology: CC
definition:
A prominent mass in the cytoplasm of previtellogenic oocytes. The cloud contains both mitochondria and electron-dense granulofibrillar material (GFM) and is the source of germinal granule material.


go_id: GO:0032021
term: NELF complex
ontology: CC
definition:
A complex of five proteins, designated NELF-A, -B, -C, -D, and -E in human, that can physically associate with RNP polymerase II to induce transcriptional pausing.


go_id: GO:0032024
term: positive regulation of insulin secretion
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the regulated release of insulin.


go_id: GO:0032025
term: response to cobalt ion
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cobalt ion stimulus.


go_id: GO:0032026
term: response to magnesium ion
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a magnesium ion stimulus.


go_id: GO:0032039
term: integrator complex
ontology: CC
definition:
A protein complex that stably associates with the C-terminus of RNA polymerase II and mediates 3'-end processing of small nuclear RNAs generated by RNA polymerase II.


go_id: GO:0032040
term: small-subunit processome
ontology: CC
definition:
A large ribonucleoprotein complex that is an early preribosomal complex. In S. cerevisiae, it has a size of 80S and consists of the 35S pre-rRNA, early-associating ribosomal proteins most of which are part of the small ribosomal subunit, the U3 snoRNA and associated proteins.


go_id: GO:0032041
term: NAD-dependent histone deacetylase activity (H3-K14 specific)
ontology: MF
definition:
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 14) + H2O = histone H3 L-lysine (position 14) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 14 of the histone H3 protein.


go_id: GO:0032044
term: DSIF complex
ontology: CC
definition:
A heterodimeric protein complex formed of Spt4 and Spt5 proteins which is expressed in eukaryotes from yeast to man. DSIF is an inhibitory elongation factor that promotes RNA polymerase II transcriptional pausing, but can also stimulate transcriptional elongation under certain conditions, and may play a role in RNA processing via its physical association with mRNA capping enzymes.


go_id: GO:0032046
term: micropexophagy-specific membrane apparatus
ontology: CC
definition:
A membrane-bounded flattened sac that is formed during micropexophagy between the membrane tips of an engulfing vacuole, completing the engulfment and sequestration of peroxisomes from the cytosol, and forming a micropexophagic body within the lumen of the vacuole.


go_id: GO:0032047
term: mitosome
ontology: CC
definition:
A double-membrane-bounded organelle that functions in iron-sulfur protein maturation; evolutionarily derived from mitochondria. The mitosome has been detected only in anaerobic or microaerophilic organisms that do not have mitochondria, such as Entamoeba histolytica, Giardia intestinalis and several species of Microsporidia. These organisms are not capable of gaining energy from oxidative phosphorylation, which is normally performed by mitochondria.


go_id: GO:0032049
term: cardiolipin biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol.


go_id: GO:0032053
term: ciliary basal body organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a ciliary basal body, a short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum).


go_id: GO:0032055
term: negative regulation of translation in response to stress
ontology: BP
definition:
Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating the organism is under stress.


go_id: GO:0032056
term: positive regulation of translation in response to stress
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating the organism is under stress.


go_id: GO:0032057
term: negative regulation of translational initiation in response to stress
ontology: BP
definition:
Any process that stops, prevents or reduces the rate of translation initiation as a result of a stimulus indicating the organism is under stress.


go_id: GO:0032058
term: positive regulation of translational initiation in response to stress
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of translation initiation as a result of a stimulus indicating the organism is under stress.


go_id: GO:0032059
term: bleb
ontology: CC
definition:
A cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Blebs are formed during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.


go_id: GO:0032060
term: bleb assembly
ontology: BP
definition:
The assembly of a bleb, a cell extension caused by localized decoupling of the cytoskeleton from the plasma membrane and characterized by rapid formation, rounded shape, and scarcity of organelles within the protrusion. Plasma membrane blebbing occurs during apoptosis and other cellular processes, including cell locomotion, cell division, and as a result of physical or chemical stresses.


go_id: GO:0032061
term: negative regulation of translation in response to osmotic stress
ontology: BP
definition:
Any process that stops, prevents or reduces the rate of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


go_id: GO:0032062
term: positive regulation of translation in response to osmotic stress
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of translation as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


go_id: GO:0032063
term: negative regulation of translational initiation in response to osmotic stress
ontology: BP
definition:
Any process that stops, prevents or reduces the rate of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


go_id: GO:0032064
term: positive regulation of translational initiation in response to osmotic stress
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of translation initiation, as a result of a stimulus indicating an increase or decrease in the concentration of solutes outside the organism or cell.


go_id: GO:0032065
term: maintenance of protein location in cell cortex
ontology: BP
definition:
A process in which a protein or protein complex is maintained in a specific location in the cell cortex.


go_id: GO:0032067
term: type IV site-specific deoxyribonuclease activity
ontology: MF
definition:
Catalysis of the endonucleolytic cleavage of DNA in a site specific manner. Cleavage is dependent on the presence of a specific recognition site in the DNA which must be modified (e.g. methylated, hydroxymethylated, glucosyl-hydroxymethylated).


go_id: GO:0032068
term: type IV site-specific deoxyribonuclease complex
ontology: CC
definition:
A complex consisting of two proteins which acts as an endonuclease in DNA sequences containing a specific modified recognition site. Modifications may include methylation, hydroxymethylation, and glucosyl-hydroxymethylation.


go_id: GO:0032069
term: regulation of nuclease activity
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids.


go_id: GO:0032070
term: regulation of deoxyribonuclease activity
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.


go_id: GO:0032071
term: regulation of endodeoxyribonuclease activity
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.


go_id: GO:0032072
term: regulation of restriction endodeoxyribonuclease activity
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.


go_id: GO:0032073
term: negative regulation of restriction endodeoxyribonuclease activity
ontology: BP
definition:
Any process that stops or reduces the rate of a restriction endodeoxyribonuclease activity, the catalysis of endonucleolytic cleavage of DNA in a site-specific manner, resulting in double-strand breaks.


go_id: GO:0032074
term: negative regulation of nuclease activity
ontology: BP
definition:
Any process that stops or reduces the rate of nuclease activity, the hydrolysis of ester linkages within nucleic acids.


go_id: GO:0032075
term: positive regulation of nuclease activity
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of nuclease activity, the hydrolysis of ester linkages within nucleic acids.


go_id: GO:0032076
term: negative regulation of deoxyribonuclease activity
ontology: BP
definition:
Any process that stops or reduces the rate of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.


go_id: GO:0032077
term: positive regulation of deoxyribonuclease activity
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of deoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid.


go_id: GO:0032078
term: negative regulation of endodeoxyribonuclease activity
ontology: BP
definition:
Any process that stops or reduces the rate of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.


go_id: GO:0032079
term: positive regulation of endodeoxyribonuclease activity
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of endodeoxyribonuclease activity, the hydrolysis of ester linkages within deoxyribonucleic acid by creating internal breaks.


go_id: GO:0032084
term: regulation of type I site-specific deoxyribonuclease activity
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a type I restriction endodeoxyribonuclease activity.


go_id: GO:0032085
term: regulation of type II site-specific deoxyribonuclease activity
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a type II restriction endodeoxyribonuclease activity.


go_id: GO:0032086
term: regulation of type III site-specific deoxyribonuclease activity
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a type III restriction endodeoxyribonuclease activity.


go_id: GO:0032087
term: regulation of type IV site-specific deoxyribonuclease activity
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a type IV restriction endodeoxyribonuclease activity.


go_id: GO:0032088
term: negative regulation of NF-kappaB transcription factor activity
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor NF-kappaB.


go_id: GO:0032089
term: NACHT domain binding
ontology: MF
definition:
Binding to a NACHT (NAIP, CIITA, HET-E and TP1) domain. The NACHT domain consists of seven distinct conserved motifs, including an ATP/GTPase specific P-loop, a Mg(2+)-binding site and five more specific motifs.


go_id: GO:0032090
term: Pyrin domain binding
ontology: MF
definition:
Binding to a Pyrin (PAAD/DAPIN) domain, a protein-protein interaction domain that has the same fold as the Death domain.


go_id: GO:0032093
term: SAM domain binding
ontology: MF
definition:
Binding to a SAM (Sterile Alpha Motif) domain, which is a 70-amino acid protein sequence that participates in protein-protein, protein-lipid, and protein-RNA interactions and is conserved from lower to higher eukaryotes.


go_id: GO:0032094
term: response to food
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a food stimulus; food is anything which, when taken into the body, serves to nourish or build up the tissues or to supply body heat.


go_id: GO:0032096
term: negative regulation of response to food
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of a response to a food stimulus.


go_id: GO:0032102
term: negative regulation of response to external stimulus
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an external stimulus.


go_id: GO:0032104
term: regulation of response to extracellular stimulus
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a response to an extracellular stimulus.


go_id: GO:0032105
term: negative regulation of response to extracellular stimulus
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of a response to an extracellular stimulus.


go_id: GO:0032106
term: positive regulation of response to extracellular stimulus
ontology: BP
definition:
Any process that activates, maintains or increases the rate of a response to an extracellular stimulus.


go_id: GO:0032108
term: negative regulation of response to nutrient levels
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of a response to nutrient levels.


go_id: GO:0032109
term: positive regulation of response to nutrient levels
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of a response to nutrient levels.


go_id: GO:0032112
term: negative regulation of protein histidine kinase activity
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of protein histidine kinase activity.


go_id: GO:0032113
term: regulation of carbohydrate phosphatase activity
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of carbohydrate phosphatase activity, the catalysis of the hydrolysis of phosphate from a carbohydrate phosphate.


go_id: GO:0032114
term: regulation of glucose-6-phosphatase activity
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of glucose-6-phosphatase activity, the catalysis of the reaction: D-glucose 6-phosphate + H2O = D-glucose + phosphate.


go_id: GO:0032115
term: sorbose reductase activity
ontology: MF
definition:
Catalysis of the reaction: D-glucitol + NADP(+) = L-sorbose + H(+) + NADPH. The reaction may occur, to a minor extent, in the reverse direction.


go_id: GO:0032116
term: SMC loading complex
ontology: CC
definition:
A protein complex required for the loading of a structural maintenance of chromosome (SMC) complex, such as cohesin, condensin or SMC5/SMC6, onto DNA. Appears to be eukaryotically conserved.


go_id: GO:0032117
term: horsetail-astral microtubule array
ontology: CC
definition:
An array of astral microtubules that emanates from the spindle pole body during meiosis and facilitates horsetail nuclear movement.


go_id: GO:0032118
term: horsetail-astral microtubule organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the horsetail-astral array, a structure of astral microtubules that emanates from the spindle pole body during meiosis.


go_id: GO:0032119
term: sequestering of zinc ion
ontology: BP
definition:
The process of binding or confining zinc ions such that they are separated from other components of a biological system.


go_id: GO:0032120
term: ascospore-type prospore membrane formation
ontology: BP
definition:
The process in which the nascent membrane forms at the meiotic outer plaque and grows until closure occurs and forespores, or prospores, are formed.


go_id: GO:0032121
term: meiotic attachment of telomeric heterochromatin to spindle pole body
ontology: BP
definition:
The meiotic cell cycle process in which physical connections are formed between telomeric heterochromatin and the spindle pole body, facilitating bouquet formation.


go_id: GO:0032122
term: oral apparatus organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the oral apparatus. The oral apparatus is a funnel-like structure used by the cell to collect food and channel it to the cytostome, characteristic of ciliate protozoans.


go_id: GO:0032123
term: deep fiber
ontology: CC
definition:
Inward projections of the cytoskeletal structures of the oral apparatus, which form a fiber that extends past the cytostome into the cytoplasm.


go_id: GO:0032124
term: macronucleus organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the macronucleus.


go_id: GO:0032125
term: micronucleus organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the micronucleus.


go_id: GO:0032126
term: eisosome
ontology: CC
definition:
A cell part that is composed of the eisosome membrane or MCC domain, a furrow-like plasma membrane sub-domain and associated integral transmembrane proteins, and the proteins (eisosome filaments) that form a scaffolding lattice on the cytoplasmic face. Eisosomes broadly affect overall plasma membrane organization.


go_id: GO:0032129
term: histone deacetylase activity (H3-K9 specific)
ontology: MF
definition:
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 9) + H2O = histone H3 L-lysine (position 9) + acetate. This reaction represents the removal of an acetyl group from lysine at position 9 of the histone H3 protein.


go_id: GO:0032130
term: medial membrane band assembly
ontology: BP
definition:
The assembly of a sterol-rich region of the plasma membrane at the cell surface overlying the contractile ring.


go_id: GO:0032133
term: chromosome passenger complex
ontology: CC
definition:
A eukaryotically conserved protein complex that localizes to kinetochores in early mitosis, the spindle mid-zone in anaphase B and to the telophase midbody. It has been proposed that the passenger complex coordinates various events based on its location to different structures during the course of mitosis. Complex members include the BIR-domain-containing protein Survivin, Aurora kinase, INCENP and Borealin.


go_id: GO:0032140
term: single adenine insertion binding
ontology: MF
definition:
Binding to a double-stranded DNA region containing a single adenine insertion or a deletion that results in an unpaired adenine.


go_id: GO:0032141
term: single cytosine insertion binding
ontology: MF
definition:
Binding to a double-stranded DNA region containing a single cytosine insertion or a deletion that results in an unpaired cytosine.


go_id: GO:0032142
term: single guanine insertion binding
ontology: MF
definition:
Binding to a double-stranded DNA region containing a single guanine insertion or a deletion that results in an unpaired guanine.


go_id: GO:0032143
term: single thymine insertion binding
ontology: MF
definition:
Binding to a double-stranded DNA region containing a single thymine insertion or a deletion that results in an unpaired thymine.


go_id: GO:0032149
term: response to rhamnose
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a rhamnose stimulus.


go_id: GO:0032150
term: ubiquinone biosynthetic process from chorismate
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of chorismate to 4-hydroxybenzoate.


go_id: GO:0032153
term: cell division site
ontology: CC
definition:
The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles.


go_id: GO:0032154
term: cleavage furrow
ontology: CC
definition:
The cleavage furrow is a plasma membrane invagination at the cell division site. The cleavage furrow begins as a shallow groove and eventually deepens to divide the cytoplasm.


go_id: GO:0032156
term: septin cytoskeleton
ontology: CC
definition:
The part of the cytoskeleton (the internal framework of a cell) composed of septins and associated proteins. Includes septin cytoskeleton-associated complexes.


go_id: GO:0032157
term: prospore contractile ring
ontology: CC
definition:
A contractile ring, i.e. a cytoskeletal structure composed of actin filaments and myosin, that forms beneath the plasma membrane of the prospore envelope in meiotic cells in preparation for completing cytokinesis.


go_id: GO:0032158
term: septin band
ontology: CC
definition:
A diffuse ring composed of a series of septin bars that run parallel to the long axis of the cell. This type of septin structure has been observed in a number of locations associated with polarized grown and/or deposition of new membrane, but not with cytokinesis, such as at the shmoo (mating projection) neck, at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously.


go_id: GO:0032159
term: septin cap
ontology: CC
definition:
A faint structure formed of septins found at the leading edge of growth in germ tubes and hyphae in fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol.


go_id: GO:0032160
term: septin filament array
ontology: CC
definition:
Arrays of septin filaments, or bars, found in a series of filamentous structures. Such structures have been observed in the prospore membrane during spore formation in S. cerevisiae and in the chlamydospore membrane during chlamydospore formation in C. albicans.


go_id: GO:0032161
term: cleavage apparatus septin structure
ontology: CC
definition:
Any of a series of structures composed of septins and septin-associated proteins localized to the cleavage plane which are involved in cytokinesis.


go_id: GO:0032162
term: mating projection septin band
ontology: CC
definition:
A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the neck of a shmoo (mating projection).


go_id: GO:0032163
term: hyphal septin band
ontology: CC
definition:
A septin band, i.e. a diffuse ring composed of a series of septin bars running parallel to the long axis of the cell, located at the junction between the mother cell and the germ tube (hypha) of a fungal cell growing filamentously.


go_id: GO:0032164
term: hyphal septin cap
ontology: CC
definition:
A faint structure formed of septins found at the leading edge of growth in hyphae of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol.


go_id: GO:0032165
term: prospore septin filament array
ontology: CC
definition:
Arrays of septin filaments, or bars, found in a series of filamentous structures; observed in the prospore membrane during spore formation.


go_id: GO:0032166
term: chlamydospore septin filament array
ontology: CC
definition:
Arrays of septin filaments, or bars, found in a series of filamentous structures. Observed in the chlamydospore membrane during chlamydospore formation.


go_id: GO:0032168
term: hyphal septin ring
ontology: CC
definition:
A tight ring-shaped structure that forms in the division plane within hyphae of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins.


go_id: GO:0032169
term: prospore septin ring
ontology: CC
definition:
A tight ring-shaped structure that forms in the division plane at the site of cytokinesis in a prospore; composed of septins as well as septin-associated proteins.


go_id: GO:0032170
term: pseudohyphal septin ring
ontology: CC
definition:
A tight ring-shaped structure that forms in the division plane at the junction between the mother cell and a pseudohyphal projection; composed of septins as well as septin-associated proteins.


go_id: GO:0032171
term: germ tube septin cap
ontology: CC
definition:
A faint structure formed of septins found at the leading edge of growth in germ tubes of fungal cells growing filamentously. This cap of septins colocalizes with a region of the plasma membrane that is rich in ergosterol.


go_id: GO:0032172
term: germ tube septin ring
ontology: CC
definition:
A tight ring-shaped structure that forms in the division plane within the germ tube of filamentous fungi at sites where a septum will form; composed of septins as well as septin-associated proteins.


go_id: GO:0032173
term: septin collar
ontology: CC
definition:
A tubular, hourglass-shaped structure composed of highly ordered arrays of septin filaments; in budding yeast cells, the septin collar forms from the initial septin ring by expanding into the daughter cell.


go_id: GO:0032174
term: cellular bud neck septin collar
ontology: CC
definition:
A tubular structure with flared ends, shaped like an hourglass and composed of highly ordered arrays of septin filaments, that forms at the bud neck of a dividing cell. In S. cerevisiae, this structure is located at the bud neck throughout most of the cell cycle and the septins are fixed within the structure, not exchanging with soluble septins. This septin structure acts as a scaffold for other proteins that function at the bud neck.


go_id: GO:0032175
term: mating projection septin ring
ontology: CC
definition:
A septin ring, i.e. a ring-shaped structure composed of septins and septin-associated proteins, located at the neck of a shmoo (mating projection). The septin ring in the neck of a shmoo may act as a barrier to localize mating factors in the shmoo tip.


go_id: GO:0032176
term: split septin rings
ontology: CC
definition:
A pair of rings that flank the site of cell division, formed by splitting of the septin ring (or collar) prior to cytokinesis; this double ring structure is thought to trap proteins needed for cytokinesis or the formation of the new membrane or cell wall between the two septin rings. Split septin rings are known to occur in budding yeast cells and probably occur in other cell types as well.


go_id: GO:0032177
term: cellular bud neck split septin rings
ontology: CC
definition:
Two separate septin rings that are formed from the septin collar at the time of cytokinesis in cells that divide by budding. These two rings are thought to delineate a special compartment in which factors involved in cytokinesis are concentrated.


go_id: GO:0032178
term: medial membrane band
ontology: CC
definition:
A sterol-rich region of the plasma membrane which forms at the cell surface overlying the contractile ring and spreads into the invaginating plasma membrane surrounding the septum.


go_id: GO:0032180
term: ubiquinone biosynthetic process from tyrosine
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of ubiquinone, beginning with the conversion of tyrosine to 4-hydroxybenzoate.


go_id: GO:0032181
term: dinucleotide repeat insertion binding
ontology: MF
definition:
Binding to a double-stranded DNA region containing a dinucleotide repeat insertion or a deletion resulting in unpaired dinucleotide repeats.


go_id: GO:0032185
term: septin cytoskeleton organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising septin complexes and their associated proteins.


go_id: GO:0032186
term: cellular bud neck septin ring organization
ontology: BP
definition:
Control of the formation, spatial distribution, and breakdown of a septin ring located at the bud neck.


go_id: GO:0032187
term: actomyosin contractile ring localization
ontology: BP
definition:
The process in which a contractile ring is assembled and/or maintained in a specific location, in the context of cytokinesis that takes place as part of a cell cycle.


go_id: GO:0032188
term: establishment of actomyosin contractile ring localization
ontology: BP
definition:
The process in which a contractile ring is assembled in a specific location as part of a process of cell cycle cytokinesis.


go_id: GO:0032189
term: maintenance of actomyosin contractile ring localization
ontology: BP
definition:
Any process in which an actomyosin contractile ring is maintained in a location and prevented from moving elsewhere.


go_id: GO:0032190
term: acrosin binding
ontology: MF
definition:
Binding to acrosin, a protein that is found in the acrosomes of sperm and possesses protease and carbohydrate binding activities.


go_id: GO:0032193
term: ubiquinone biosynthetic process via 2-polyprenylphenol
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 2-polyprenylphenol and 2-polyprenyl-6-hydroxyphenol.


go_id: GO:0032194
term: ubiquinone biosynthetic process via 3,4-dihydroxy-5-polyprenylbenzoate
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of ubiquinone, via the intermediates 3,4-dihydroxy-5-polyprenylbenzoate and 3-methoxy-4-hydroxy-5-polyprenylbenzoate.


go_id: GO:0032195
term: post-lysosomal vacuole
ontology: CC
definition:
A membrane-bounded intracellular vesicle formed late in the endocytic pathway when the pH in the vacuole becomes neutral prior to exocytosis.


go_id: GO:0032196
term: transposition
ontology: BP
definition:
Any process involved in mediating the movement of discrete segments of DNA between nonhomologous sites.


go_id: GO:0032197
term: transposition, RNA-mediated
ontology: BP
definition:
Any process involved in a type of transpositional recombination which occurs via an RNA intermediate.


go_id: GO:0032198
term: MITE transposition
ontology: BP
definition:
Any process involved in the transposition of miniature inverted-repeat transposable elements (MITEs).


go_id: GO:0032200
term: telomere organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of telomeres, terminal regions of a linear chromosome that include the telomeric DNA repeats and associated proteins.


go_id: GO:0032201
term: telomere maintenance via semi-conservative replication
ontology: BP
definition:
The process in which telomeric DNA is synthesized semi-conservatively by the conventional replication machinery and telomeric accessory factors as part of cell cycle DNA replication.


go_id: GO:0032202
term: telomere assembly
ontology: BP
definition:
A cellular process that results in the aggregation, arrangement and bonding together of a set of components to form a telomere at a non-telomeric double-stranded DNA end. A telomere is a terminal region of a linear chromosome that includes telomeric DNA repeats and associated proteins.


go_id: GO:0032203
term: telomere formation via telomerase
ontology: BP
definition:
A cellular process that results in the formation of a telomere at a non-telomeric double-stranded DNA end that involves the activity of a telomerase enzyme.


go_id: GO:0032204
term: regulation of telomere maintenance
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.


go_id: GO:0032205
term: negative regulation of telomere maintenance
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.


go_id: GO:0032206
term: positive regulation of telomere maintenance
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of a process that affects and monitors the activity of telomeric proteins and the length of telomeric DNA.


go_id: GO:0032207
term: regulation of telomere maintenance via recombination
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length.


go_id: GO:0032208
term: negative regulation of telomere maintenance via recombination
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length.


go_id: GO:0032209
term: positive regulation of telomere maintenance via recombination
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of a recombinational process involved in the maintenance of proper telomeric length.


go_id: GO:0032210
term: regulation of telomere maintenance via telomerase
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the addition of telomeric repeats by telomerase.


go_id: GO:0032211
term: negative regulation of telomere maintenance via telomerase
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of telomeric repeats by telomerase.


go_id: GO:0032212
term: positive regulation of telomere maintenance via telomerase
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the addition of telomeric repeats by telomerase.


go_id: GO:0032213
term: regulation of telomere maintenance via semi-conservative replication
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the semi-conservative replication of telomeric DNA.


go_id: GO:0032214
term: negative regulation of telomere maintenance via semi-conservative replication
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the semi-conservative replication of telomeric DNA.


go_id: GO:0032215
term: positive regulation of telomere maintenance via semi-conservative replication
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the semi-conservative replication of telomeric DNA.


go_id: GO:0032216
term: glucosaminyl-phosphatidylinositol O-acyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: glucosaminyl-phosphatidylinositol + fatty acyl-CoA = glucosaminyl-acyl-phasphotidylinositol + CoA.


go_id: GO:0032217
term: riboflavin transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of riboflavin from one side of a membrane to the other. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins.


go_id: GO:0032218
term: riboflavin transport
ontology: BP
definition:
The directed movement of riboflavin into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Riboflavin (vitamin B2) is a water-soluble B-complex vitamin, converted in the cell to FMN and FAD, cofactors required for the function of flavoproteins.


go_id: GO:0032219
term: cell wall macromolecule catabolic process involved in cytogamy
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of macromolecules forming part of a cell wall that contribute to cytogamy.


go_id: GO:0032220
term: plasma membrane fusion involved in cytogamy
ontology: BP
definition:
The joining of two or more lipid bilayer membranes that surround cells, that contributes to cytogamy.


go_id: GO:0032221
term: Rpd3S/Clr6-CII complex
ontology: CC
definition:
A eukaryotically conserved histone deacetylase complex which deacetylates histones across gene coding regions. Composed of a catalytic histone deacetylase subunit, a chromodomain protein, a SIN3 family co-repressor, and a WD repeat protein (Clr6p, Alp13p, Pst2p, and Prw1p respectively in Schizosaccharomyces; Rpd3p, Sin3p, Ume1p, Rco1p and Eaf3 in Saccharomyces; homologs thereof in other species).


go_id: GO:0032222
term: regulation of synaptic transmission, cholinergic
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.


go_id: GO:0032223
term: negative regulation of synaptic transmission, cholinergic
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.


go_id: GO:0032224
term: positive regulation of synaptic transmission, cholinergic
ontology: BP
definition:
Any process that activates, maintains or increases the frequency, rate or extent of cholinergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter acetylcholine.


go_id: GO:0032225
term: regulation of synaptic transmission, dopaminergic
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.


go_id: GO:0032226
term: positive regulation of synaptic transmission, dopaminergic
ontology: BP
definition:
Any process that activates, maintains or increases the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.


go_id: GO:0032227
term: negative regulation of synaptic transmission, dopaminergic
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of dopaminergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter dopamine.


go_id: GO:0032228
term: regulation of synaptic transmission, GABAergic
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).


go_id: GO:0032229
term: negative regulation of synaptic transmission, GABAergic
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).


go_id: GO:0032230
term: positive regulation of synaptic transmission, GABAergic
ontology: BP
definition:
Any process that activates, maintains or increases the frequency, rate or extent of GABAergic synaptic transmission, the process of communication from a neuron to another neuron across a synapse using the neurotransmitter gamma-aminobutyric acid (GABA).


go_id: GO:0032232
term: negative regulation of actin filament bundle assembly
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the assembly of actin filament bundles.


go_id: GO:0032233
term: positive regulation of actin filament bundle assembly
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the assembly of actin filament bundles.


go_id: GO:0032238
term: adenosine transport
ontology: BP
definition:
The directed movement of adenosine, adenine riboside, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032239
term: regulation of nucleobase-containing compound transport
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032240
term: negative regulation of nucleobase-containing compound transport
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032241
term: positive regulation of nucleobase-containing compound transport
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the directed movement of nucleobases, nucleosides, nucleotides and nucleic acids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032242
term: regulation of nucleoside transport
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032243
term: negative regulation of nucleoside transport
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032244
term: positive regulation of nucleoside transport
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the directed movement of a nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032245
term: regulation of purine nucleoside transport
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032246
term: regulation of pyrimidine nucleoside transport
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of a pyrimidine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032247
term: negative regulation of purine nucleoside transport
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032248
term: positive regulation of purine nucleoside transport
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the directed movement of a purine nucleoside into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032249
term: regulation of adenosine transport
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032250
term: negative regulation of adenosine transport
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032251
term: positive regulation of adenosine transport
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the directed movement of adenosine into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032252
term: secretory granule localization
ontology: BP
definition:
Any process in which a secretory granule is transported to, and/or maintained in, a specific location within the cell.


go_id: GO:0032253
term: dense core granule localization
ontology: BP
definition:
Any process in which a dense core granule is transported to, and/or maintained in, a specific location within the cell.


go_id: GO:0032255
term: maintenance of secretory granule location
ontology: BP
definition:
Any process in which a secretory granule is maintained in a specific location within a cell and prevented from moving elsewhere.


go_id: GO:0032257
term: maintenance of dense core granule location
ontology: BP
definition:
Any process in which a dense core granule is maintained in a specific location within a cell and prevented from moving elsewhere.


go_id: GO:0032258
term: cytoplasm to vacuole transport by the Cvt pathway
ontology: BP
definition:
A cytoplasm to vacuole targeting pathway that uses machinery common with autophagy. The Cvt vesicle is formed when the receptor protein, Atg19, binds to the complexes of the target protein (aminopeptidase or alpha-mannosidase homododecamers), forming the Cvt complex. Atg11 binds to Atg9 and transports the Cvt complex to the pre-autophagosome (PAS). The phagophore membrane expands around the Cvt complex (excluding bulk cytoplasm) forming the Cvt vesicle. This pathway is mostly observed in yeast.


go_id: GO:0032260
ontology: BP
term:
response to jasmonic acid stimulus involved in jasmonic acid and ethylene-dependent systemic resistance

definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a jasmonic acid stimulus received in the context of the jasmonic acid- and ethylene (ethene)-dependent process that confers broad spectrum systemic resistance to disease in response to wounding or a pathogen.


go_id: GO:0032262
term: pyrimidine nucleotide salvage
ontology: BP
definition:
Any process which produces a pyrimidine nucleotide from derivatives of it, without de novo synthesis.


go_id: GO:0032263
term: GMP salvage
ontology: BP
definition:
Any process which produces guanosine monophosphate from derivatives of it, without de novo synthesis.


go_id: GO:0032265
term: XMP salvage
ontology: BP
definition:
Any process which produces xanthosine monophosphate from derivatives of it, without de novo synthesis.


go_id: GO:0032266
term: phosphatidylinositol-3-phosphate binding
ontology: MF
definition:
Binding to phosphatidylinositol-3-phosphate, a derivative of phosphatidylinositol in which the inositol ring is phosphorylated at the 3' position.


go_id: GO:0032267
term: tRNA(Ile)-lysidine synthase activity
ontology: MF
definition:
Catalysis of the ligation of lysine onto the cytidine residue present at the wobble position (usually position 34) of an AUA-specific isoleucine tRNA, to form the derivative lysidine. This modification converts both the codon specificity of tRNA(Ile) from AUG to AUA and its amino acid specificity from methionine to isoleucine.


go_id: GO:0032268
term: regulation of cellular protein metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving a protein, occurring at the level of an individual cell.


go_id: GO:0032271
term: regulation of protein polymerization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the process of creating protein polymers.


go_id: GO:0032272
term: negative regulation of protein polymerization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the process of creating protein polymers.


go_id: GO:0032273
term: positive regulation of protein polymerization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the process of creating protein polymers.


go_id: GO:0032274
term: gonadotropin secretion
ontology: BP
definition:
The regulated release of a gonadotropin, any hormone that stimulates the gonads, especially follicle-stimulating hormone and luteinizing hormone.


go_id: GO:0032275
term: luteinizing hormone secretion
ontology: BP
definition:
The regulated release of luteinizing hormone, a gonadotropic glycoprotein hormone secreted by the anterior pituitary.


go_id: GO:0032276
term: regulation of gonadotropin secretion
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the regulated release of a gonadotropin.


go_id: GO:0032277
term: negative regulation of gonadotropin secretion
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a gonadotropin.


go_id: GO:0032278
term: positive regulation of gonadotropin secretion
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the regulated release of a gonadotropin.


go_id: GO:0032279
term: asymmetric synapse
ontology: CC
definition:
A type of synapse occurring between an axon and a dendritic spine or dendritic shaft. Asymmetric synapses, the most abundant synapse type in the central nervous system, involve axons that contain predominantly spherical vesicles and contain a thickened postsynaptic density.  Most or all synapses of this type are excitatory.


go_id: GO:0032280
term: symmetric synapse
ontology: CC
definition:
A synapse that lacks an electron dense postsynaptic specialization. In vertebtrates, these occur primarily on dendrite shafts and neuronal cell bodies and involve persynapses containing clusters of predominantly flattened or elongated vesicles and are typcially inhibitory.


go_id: GO:0032281
term: AMPA glutamate receptor complex
ontology: CC
definition:
An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. The AMPA receptors mediate fast synaptic transmission in the CNS and are composed of subunits GluR1-4, products from separate genes. These subunits have an extracellular N-terminus and an intracellular C-terminus.


go_id: GO:0032286
term: central nervous system myelin maintenance
ontology: BP
definition:
The process in which the structure and material content of mature central nervous system myelin is kept in a functional state.


go_id: GO:0032287
term: peripheral nervous system myelin maintenance
ontology: BP
definition:
The process in which the structure and material content of mature peripheral nervous system myelin is kept in a functional state.


go_id: GO:0032288
term: myelin assembly
ontology: BP
definition:
The process in which the wraps of cell membrane that constitute myelin are laid down around an axon in the central or peripheral nervous system.


go_id: GO:0032289
term: central nervous system myelin formation
ontology: BP
definition:
The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by an oligodendrocyte in the central nervous system.


go_id: GO:0032290
term: peripheral nervous system myelin formation
ontology: BP
definition:
The process in which the wraps of cell membrane that constitute myelin are laid down around an axon by Schwann cells in the peripheral nervous system.


go_id: GO:0032291
term: axon ensheathment in central nervous system
ontology: BP
definition:
The process in which a glial cell membrane closes around an axon in the central nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction.


go_id: GO:0032292
term: peripheral nervous system axon ensheathment
ontology: BP
definition:
The process in which a Schwann cell membrane closes around an axon in the peripheral nervous system. This can be a myelinating or a non-myelinating neuron-glial interaction.


go_id: GO:0032293
term: non-myelinated axon ensheathment in central nervous system
ontology: BP
definition:
The process in which a non-myelinating glial cell membrane encircles an axon in the central nervous system.


go_id: GO:0032294
term: peripheral nervous system non-myelinated axon ensheathment
ontology: BP
definition:
The process in which a non-myelinating Schwann cell membrane encircles an axon in the peripheral nervous system. A single non-myelinating Schwann cell will typically associate with multiple axons.


go_id: GO:0032297
term: negative regulation of DNA-templated DNA replication initiation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication.


go_id: GO:0032298
term: positive regulation of DNA-templated DNA replication initiation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of initiation of DNA-dependent DNA replication.


go_id: GO:0032299
term: ribonuclease H2 complex
ontology: CC
definition:
A protein complex that possesses ribonuclease H activity, in which the catalytic subunit is a member of the RNase H2 (or HII) class. For example, in Saccharomyces the complex contains Rnh201p, Rnh202p and Rnh203p.


go_id: GO:0032301
term: MutSalpha complex
ontology: CC
definition:
A heterodimer involved in the recognition and repair of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MSH2 and MSH6.


go_id: GO:0032302
term: MutSbeta complex
ontology: CC
definition:
A heterodimer involved in binding to and correcting insertion/deletion mutations. In human the complex consists of two subunits, MSH2 and MSH3.


go_id: GO:0032303
term: regulation of icosanoid secretion
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the controlled release of an icosanoid from a cell.


go_id: GO:0032304
term: negative regulation of icosanoid secretion
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the controlled release of an icosanoid from a cell.


go_id: GO:0032305
term: positive regulation of icosanoid secretion
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the controlled release of an icosanoid from a cell.


go_id: GO:0032306
term: regulation of prostaglandin secretion
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the regulated release of a prostaglandin from a cell.


go_id: GO:0032307
term: negative regulation of prostaglandin secretion
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of a prostaglandin from a cell.


go_id: GO:0032308
term: positive regulation of prostaglandin secretion
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the regulated release of a prostaglandin from a cell.


go_id: GO:0032309
term: icosanoid secretion
ontology: BP
definition:
The controlled release of icosanoids, any of a group of C20 polyunsaturated fatty acids from a cell or a tissue.


go_id: GO:0032310
term: prostaglandin secretion
ontology: BP
definition:
The regulated release of a prostaglandin, any of a group of biologically active metabolites which contain a cyclopentane ring, from a cell or a tissue.


go_id: GO:0032311
term: angiogenin-PRI complex
ontology: CC
definition:
A stable heterodimer of angiogenin and placental ribonuclease inhibitor; interaction between angiogenin and PRI prevents angiogenin binding to its receptor to stimulate angiogenesis.


go_id: GO:0032322
term: ubiquinone catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of ubiquinone, a lipid-soluble electron-transporting coenzyme.


go_id: GO:0032324
term: molybdopterin cofactor biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.


go_id: GO:0032325
term: molybdopterin cofactor catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands.


go_id: GO:0032326
term: Mo-molybdopterin cofactor catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.


go_id: GO:0032327
term: W-molybdopterin cofactor catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands.


go_id: GO:0032328
term: alanine transport
ontology: BP
definition:
The directed movement of alanine, 2-aminopropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032329
term: serine transport
ontology: BP
definition:
The directed movement of L-serine, 2-amino-3-hydroxypropanoic acid, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032331
term: negative regulation of chondrocyte differentiation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of chondrocyte differentiation.


go_id: GO:0032332
term: positive regulation of chondrocyte differentiation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of chondrocyte differentiation.


go_id: GO:0032333
term: activin secretion
ontology: BP
definition:
The regulated release of activin, a nonsteroidal regulator composed of two covalently linked beta subunits, which is synthesized in the pituitary gland and gonads and stimulates the secretion of follicle-stimulating hormone.


go_id: GO:0032334
term: inhibin secretion
ontology: BP
definition:
The regulated release of an inhibin, either of two glycoproteins (designated A and B), secreted by the gonads and present in seminal plasma and follicular fluid, that inhibit pituitary production of follicle-stimulating hormone.


go_id: GO:0032335
term: regulation of activin secretion
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the regulated release of activin from a cell.


go_id: GO:0032336
term: negative regulation of activin secretion
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of activin from a cell.


go_id: GO:0032337
term: positive regulation of activin secretion
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the regulated release of activin from a cell.


go_id: GO:0032338
term: regulation of inhibin secretion
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the regulated release of inhibin from a cell.


go_id: GO:0032339
term: negative regulation of inhibin secretion
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of inhibin from a cell.


go_id: GO:0032340
term: positive regulation of inhibin secretion
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the regulated release of inhibin from a cell.


go_id: GO:0032341
term: aldosterone metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance.


go_id: GO:0032342
term: aldosterone biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance.


go_id: GO:0032343
term: aldosterone catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of aldosterone, a corticosteroid hormone that is produced by the zona glomerulosa of the adrenal cortex and regulates salt (sodium and potassium) and water balance.


go_id: GO:0032344
term: regulation of aldosterone metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving aldosterone.


go_id: GO:0032345
term: negative regulation of aldosterone metabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving aldosterone.


go_id: GO:0032346
term: positive regulation of aldosterone metabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving aldosterone.


go_id: GO:0032347
term: regulation of aldosterone biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.


go_id: GO:0032348
term: negative regulation of aldosterone biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.


go_id: GO:0032349
term: positive regulation of aldosterone biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of aldosterone.


go_id: GO:0032350
term: regulation of hormone metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving any hormone.


go_id: GO:0032351
term: negative regulation of hormone metabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways involving any hormone.


go_id: GO:0032352
term: positive regulation of hormone metabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways involving any hormone.


go_id: GO:0032353
term: negative regulation of hormone biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of hormones.


go_id: GO:0032354
term: response to follicle-stimulating hormone
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a follicle-stimulating hormone stimulus.


go_id: GO:0032355
term: response to estradiol
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stimulus by estradiol, a C18 steroid hormone hydroxylated at C3 and C17 that acts as a potent estrogen.


go_id: GO:0032361
term: pyridoxal phosphate catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6.


go_id: GO:0032363
term: FMN catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of FMN, riboflavin 5'-(dihydrogen phosphate), a coenzyme for a number of oxidative enzymes including NADH dehydrogenase.


go_id: GO:0032364
term: oxygen homeostasis
ontology: BP
definition:
A homeostatic process involved in the maintenance of an internal steady state of oxygen within an organism or cell.


go_id: GO:0032368
term: regulation of lipid transport
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032369
term: negative regulation of lipid transport
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032370
term: positive regulation of lipid transport
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the directed movement of lipids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032371
term: regulation of sterol transport
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032372
term: negative regulation of sterol transport
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032373
term: positive regulation of sterol transport
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the directed movement of sterols into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032374
term: regulation of cholesterol transport
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032375
term: negative regulation of cholesterol transport
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032376
term: positive regulation of cholesterol transport
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032377
term: regulation of intracellular lipid transport
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of lipids within cells.


go_id: GO:0032378
term: negative regulation of intracellular lipid transport
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of lipids within cells.


go_id: GO:0032379
term: positive regulation of intracellular lipid transport
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the directed movement of lipids within cells.


go_id: GO:0032380
term: regulation of intracellular sterol transport
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of sterols within cells.


go_id: GO:0032381
term: negative regulation of intracellular sterol transport
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of sterols within cells.


go_id: GO:0032382
term: positive regulation of intracellular sterol transport
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the directed movement of sterols within cells.


go_id: GO:0032383
term: regulation of intracellular cholesterol transport
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of cholesterol within cells.


go_id: GO:0032384
term: negative regulation of intracellular cholesterol transport
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of cholesterol within cells.


go_id: GO:0032385
term: positive regulation of intracellular cholesterol transport
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the directed movement of cholesterol within cells.


go_id: GO:0032386
term: regulation of intracellular transport
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of substances within cells.


go_id: GO:0032387
term: negative regulation of intracellular transport
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of substances within cells.


go_id: GO:0032388
term: positive regulation of intracellular transport
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the directed movement of substances within cells.


go_id: GO:0032389
term: MutLalpha complex
ontology: CC
definition:
A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS2.


go_id: GO:0032390
term: MutLbeta complex
ontology: CC
definition:
A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In human the complex consists of two subunits, MLH1 and PMS1.


go_id: GO:0032391
term: photoreceptor connecting cilium
ontology: CC
definition:
The portion of the photoreceptor cell cilium linking the photoreceptor inner and outer segments. It's considered to be equivalent to the ciliary transition zone.


go_id: GO:0032392
term: DNA geometric change
ontology: BP
definition:
The process in which a transformation is induced in the geometry of a DNA double helix, resulting in a change in twist, writhe, or both, but with no change in linking number. Includes the unwinding of double-stranded DNA by helicases.


go_id: GO:0032393
term: MHC class I receptor activity
ontology: MF
definition:
Combining with an MHC class I protein complex to initiate a change in cellular activity. Class I here refers to classical class I molecules.


go_id: GO:0032394
term: MHC class Ib receptor activity
ontology: MF
definition:
Combining with an MHC class Ib protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.


go_id: GO:0032395
term: MHC class II receptor activity
ontology: MF
definition:
Combining with an MHC class II protein complex and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0032396
term: inhibitory MHC class I receptor activity
ontology: MF
definition:
Combining with a MHC class I protein complex to mediate signaling that inhibits activation of a lymphocyte.


go_id: GO:0032398
term: MHC class Ib protein complex
ontology: CC
definition:
A transmembrane protein complex composed of a MHC class Ib alpha chain and, in most cases, an invariant beta2-microglobin chain, and with or without a bound peptide or lipid antigen. Class Ib here refers to non-classical class I molecules, such as those of the CD1 or HLA-E gene families.


go_id: GO:0032400
term: melanosome localization
ontology: BP
definition:
Any process in which a melanosome is transported to, and/or maintained in, a specific location within the cell.


go_id: GO:0032402
term: melanosome transport
ontology: BP
definition:
The directed movement of melanosomes into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032415
term: regulation of sodium:proton antiporter activity
ontology: BP
definition:
Any process that modulates the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).


go_id: GO:0032416
term: negative regulation of sodium:proton antiporter activity
ontology: BP
definition:
Any process that stops or reduces the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).


go_id: GO:0032417
term: positive regulation of sodium:proton antiporter activity
ontology: BP
definition:
Any process that activates or increases the activity of a sodium:hydrogen antiporter, which catalyzes the reaction: Na+(out) + H+(in) = Na+(in) + H+(out).


go_id: GO:0032419
term: extrinsic component of lysosome membrane
ontology: CC
definition:
The component of an lysosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0032420
term: stereocilium
ontology: CC
definition:
An actin-based protrusion from the apical surface of auditory and vestibular hair cells and of neuromast cells. These protrusions are supported by a bundle of cross-linked actin filaments (an actin cable), oriented such that the plus (barbed) ends are at the tip of the protrusion, capped by a tip complex which bridges to the plasma. Bundles of stereocilia act as mechanosensory organelles.


go_id: GO:0032421
term: stereocilium bundle
ontology: CC
definition:
A bundle of cross-linked stereocilia, arranged around a kinocilium on the apical surface of a sensory hair cell (e.g. a neuromast, auditory or vestibular hair cell). Stereocilium bundles act as mechanosensory organelles by responding to fluid motion or fluid pressure changes.


go_id: GO:0032422
term: purine-rich negative regulatory element binding
ontology: MF
definition:
Binding to a 30-bp purine-rich negative regulatory element; the best characterized such element is found in the first intronic region of the rat cardiac alpha-myosin heavy chain gene, and contains two palindromic high-affinity Ets-binding sites (CTTCCCTGGAAG). The presence of this element restricts expression of the gene containing it to cardiac myocytes.


go_id: GO:0032426
term: stereocilium tip
ontology: CC
definition:
A distinct compartment at the tip of a stereocilium, distal to the site of attachment to the apical cell surface. It consists of a dense matrix bridging the barbed ends of the stereocilium actin filaments with the overlying plasma membrane, is dynamic compared to the shaft, and is required for stereocilium elongation.


go_id: GO:0032427
term: GBD domain binding
ontology: MF
definition:
Binding to a GTPase protein binding domain (GDB) domain. The GBD is a short motif, including a minimum region of 16 amino acids, identified in proteins that bind to small GTPases such as Cdc42 and Rac.


go_id: GO:0032428
term: beta-N-acetylgalactosaminidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of terminal non-reducing N-acetyl-D-galactosamine residues in N-acetyl-beta-D-galactosaminides.


go_id: GO:0032432
term: actin filament bundle
ontology: CC
definition:
An assembly of actin filaments that are on the same axis but may be oriented with the same or opposite polarities and may be packed with different levels of tightness.


go_id: GO:0032434
term: regulation of proteasomal ubiquitin-dependent protein catabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


go_id: GO:0032435
term: negative regulation of proteasomal ubiquitin-dependent protein catabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


go_id: GO:0032436
term: positive regulation of proteasomal ubiquitin-dependent protein catabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the breakdown of a protein or peptide by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


go_id: GO:0032437
term: cuticular plate
ontology: CC
definition:
A dense network of actin filaments found beneath the apical cell surface of hair cells, and into which stereocilia are inserted.


go_id: GO:0032438
term: melanosome organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a melanosome. A melanosome is a tissue-specific, membrane-bounded cytoplasmic organelle within which melanin pigments are synthesized and stored.


go_id: GO:0032441
term: pheophorbide a oxygenase activity
ontology: MF
definition:
Catalysis of the reaction: pheophorbide a + reduced ferredoxin + 2 O2 = red chlorophyll catabolite + oxidized ferredoxin + H2O.


go_id: GO:0032442
term: phenylcoumaran benzylic ether reductase activity
ontology: MF
definition:
Catalysis of the NADPH-dependent 7-O-4' reduction of phenylcoumaran lignans to the corresponding diphenols; for example, catalysis of the reaction: dehydrodiconiferyl alcohol + NADPH + H+ = isodihydrodehydrodiconiferyl alcohol + NADP+.


go_id: GO:0032443
term: regulation of ergosterol biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of ergosterol.


go_id: GO:0032444
term: activin responsive factor complex
ontology: CC
definition:
A transcriptionally active complex that binds to an activin response element (ARE) in the promoter of target genes, and is composed of two SMAD2 proteins, one SMAD4 protein and a Forkhead activin signal transducer (FAST) transcription factor.


go_id: GO:0032446
term: protein modification by small protein conjugation
ontology: BP
definition:
A protein modification process in which one or more groups of a small protein, such as ubiquitin or a ubiquitin-like protein, are covalently attached to a target protein.


go_id: GO:0032448
term: DNA hairpin binding
ontology: MF
definition:
Binding to a DNA region containing a hairpin. A hairpin structure forms when a DNA strand folds back on itself and intrachain base pairing occurs between inverted repeat sequences.


go_id: GO:0032449
term: CBM complex
ontology: CC
definition:
A protein complex comprising Bcl10, MALT1 and a CARD domain-containing protein (CARD9, CARD10 or CARD11); plays a role in signal transduction during NF-kappaB activation.


go_id: GO:0032453
term: histone H3-methyl-lysine-4 demethylase activity
ontology: MF
definition:
Catalysis of the removal of a methyl group from a modified lysine residue at position 4 of the histone H3 protein.


go_id: GO:0032454
term: histone H3-methyl-lysine-9 demethylase activity
ontology: MF
definition:
Catalysis of the removal of a methyl group from a modified lysine residue at position 9 of the histone H3 protein.


go_id: GO:0032456
term: endocytic recycling
ontology: BP
definition:
The directed movement of membrane-bounded vesicles from endosomes back to the plasma membrane, a trafficking pathway that promotes the recycling of internalized transmembrane proteins.


go_id: GO:0032457
term: fast endocytic recycling
ontology: BP
definition:
The directed movement of membrane-bounded vesicles from peripheral endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport.


go_id: GO:0032458
term: slow endocytic recycling
ontology: BP
definition:
The directed movement of membrane-bounded vesicles from deep (non-peripheral) compartments endocytic compartments back to the plasma membrane where they are recycled for further rounds of transport.


go_id: GO:0032460
term: negative regulation of protein oligomerization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of protein oligomerization.


go_id: GO:0032463
term: negative regulation of protein homooligomerization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of protein homooligomerization.


go_id: GO:0032464
term: positive regulation of protein homooligomerization
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of protein homooligomerization.


go_id: GO:0032465
term: regulation of cytokinesis
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the division of the cytoplasm of a cell and its separation into two daughter cells.


go_id: GO:0032466
term: negative regulation of cytokinesis
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.


go_id: GO:0032467
term: positive regulation of cytokinesis
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the division of the cytoplasm of a cell, and its separation into two daughter cells.


go_id: GO:0032468
term: Golgi calcium ion homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of calcium ions within the Golgi apparatus of a cell or between the Golgi and its surroundings.


go_id: GO:0032469
term: endoplasmic reticulum calcium ion homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of calcium ions within the endoplasmic reticulum of a cell or between the endoplasmic reticulum and its surroundings.


go_id: GO:0032475
term: otolith formation
ontology: BP
definition:
The process that gives rise to an otolith. This process pertains to the initial formation of a structure from unspecified parts.


go_id: GO:0032476
term: decaprenyl diphosphate synthase complex
ontology: CC
definition:
A complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis.


go_id: GO:0032477
term: homodimeric decaprenyl diphosphate synthase complex
ontology: CC
definition:
A homodimeric complex that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis.


go_id: GO:0032478
term: heterotetrameric decaprenyl diphosphate synthase complex
ontology: CC
definition:
A heterotetrameric complex located in the mitochondrial inner membrane that possesses di-trans,poly-cis-decaprenylcistransferase activity; involved in ubiquinone biosynthesis. In S. pombe it is a heterotetramer of Dlp1 and Dps1.


go_id: GO:0032479
term: regulation of type I interferon production
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of interferon type I production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


go_id: GO:0032480
term: negative regulation of type I interferon production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


go_id: GO:0032481
term: positive regulation of type I interferon production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


go_id: GO:0032482
term: Rab protein signal transduction
ontology: BP
definition:
The series of molecular signals within the cell that are mediated by a member of the Rab family of proteins switching to a GTP-bound active state.


go_id: GO:0032484
term: Ral protein signal transduction
ontology: BP
definition:
The series of molecular signals within the cell that are mediated by a member of the Ral family of proteins switching to a GTP-bound active state.


go_id: GO:0032486
term: Rap protein signal transduction
ontology: BP
definition:
The series of molecular signals within the cell that are mediated by a member of the Rap family of proteins switching to a GTP-bound active state.


go_id: GO:0032488
term: Cdc42 protein signal transduction
ontology: BP
definition:
The series of molecular signals within the cell that are mediated by the Cdc42 protein switching to a GTP-bound active state.


go_id: GO:0032490
term: detection of molecule of bacterial origin
ontology: BP
definition:
The series of events in which a stimulus from a molecule of bacterial origin is received and converted into a molecular signal.


go_id: GO:0032491
term: detection of molecule of fungal origin
ontology: BP
definition:
The series of events in which a stimulus from a molecule of fungal origin is received and converted into a molecular signal.


go_id: GO:0032492
term: detection of molecule of oomycetes origin
ontology: BP
definition:
The series of events in which a stimulus from a molecule of oomycetes origin is received and converted into a molecular signal.


go_id: GO:0032493
term: response to bacterial lipoprotein
ontology: BP
definition:
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bacterial lipoprotein stimulus.


go_id: GO:0032494
term: response to peptidoglycan
ontology: BP
definition:
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a peptidoglycan stimulus. Peptidoglycan is a bacterial cell wall macromolecule.


go_id: GO:0032495
term: response to muramyl dipeptide
ontology: BP
definition:
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a muramyl dipeptide stimulus. Muramyl dipeptide is derived from peptidoglycan.


go_id: GO:0032496
term: response to lipopolysaccharide
ontology: BP
definition:
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipopolysaccharide stimulus; lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.


go_id: GO:0032497
term: detection of lipopolysaccharide
ontology: BP
definition:
The series of events in which a lipopolysaccharide stimulus is received by a cell and converted into a molecular signal. Lipopolysaccharide is a major component of the cell wall of gram-negative bacteria.


go_id: GO:0032498
term: detection of muramyl dipeptide
ontology: BP
definition:
The series of events in which a muramyl dipeptide stimulus is received by a cell and converted into a molecular signal. Muramyl dipeptide is derived from peptidoglycan.


go_id: GO:0032499
term: detection of peptidoglycan
ontology: BP
definition:
The series of events in which a peptidoglycan stimulus is received by a cell and converted into a molecular signal. Peptidoglycan is a bacterial cell wall macromolecule.


go_id: GO:0032500
term: muramyl dipeptide binding
ontology: MF
definition:
Interacting selectively and non-covalently, in a non-covalent manner, with muramyl dipeptide; muramyl dipeptide is derived from peptidoglycan.


go_id: GO:0032501
term: multicellular organismal process
ontology: BP
definition:
Any biological process, occurring at the level of a multicellular organism, pertinent to its function.


go_id: GO:0032502
term: developmental process
ontology: BP
definition:
A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.


go_id: GO:0032504
term: multicellular organism reproduction
ontology: BP
definition:
The biological process in which new individuals are produced by one or two multicellular organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.


go_id: GO:0032505
term: reproduction of a single-celled organism
ontology: BP
definition:
The biological process in which new individuals are produced by one or two single-celled organisms. The new individuals inherit some proportion of their genetic material from the parent or parents.


go_id: GO:0032506
term: cytokinetic process
ontology: BP
definition:
A cellular process that is involved in cytokinesis (the division of the cytoplasm of a cell and its separation into two daughter cells).


go_id: GO:0032507
term: maintenance of protein location in cell
ontology: BP
definition:
Any process in which a protein is maintained in a specific location within, or in the membrane of, a cell, and is prevented from moving elsewhere.


go_id: GO:0032508
term: DNA duplex unwinding
ontology: BP
definition:
The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating a region of unpaired single strands.


go_id: GO:0032509
term: endosome transport via multivesicular body sorting pathway
ontology: BP
definition:
The directed movement of substances from endosomes to lysosomes or vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the target compartment.


go_id: GO:0032510
term: endosome to lysosome transport via multivesicular body sorting pathway
ontology: BP
definition:
The directed movement of substances from endosomes to lysosomes by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the lysosome.


go_id: GO:0032511
term: late endosome to vacuole transport via multivesicular body sorting pathway
ontology: BP
definition:
The directed movement of substances from endosomes to vacuoles by a pathway in which molecules are sorted into multivesicular bodies, which then fuse with the vacuole.


go_id: GO:0032517
term: SOD1-calcineurin complex
ontology: CC
definition:
A protein complex formed by the association of superoxide dismutase 1 (SOD1) with calcineurin; complex formation is implicated in activation of calcineurin by SOD1.


go_id: GO:0032523
term: silicon efflux transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of silicon from the inside of the cell to the outside of the cell across a membrane.


go_id: GO:0032525
term: somite rostral/caudal axis specification
ontology: BP
definition:
The establishment, maintenance and elaboration of the rostro-caudal axis of a somite, prior to the morphological formation of a somite boundary.


go_id: GO:0032526
term: response to retinoic acid
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a retinoic acid stimulus.


go_id: GO:0032528
term: microvillus organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus, a thin cylindrical membrane-covered projection on the surface of a cell.


go_id: GO:0032529
term: follicle cell microvillus organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell. A microvillus is a thin cylindrical membrane-covered projection on the surface of an animal cell containing a core bundle of actin filaments.


go_id: GO:0032530
term: regulation of microvillus organization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus.


go_id: GO:0032531
term: regulation of follicle cell microvillus organization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a microvillus on a follicle cell.


go_id: GO:0032537
term: host-seeking behavior
ontology: BP
definition:
The specific behavior of an organism that are associated with finding a host organism; may include behavioral responses to light, temperature, or chemical emanations from the prospective host.


go_id: GO:0032538
term: regulation of host-seeking behavior
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of any behavior associated with finding a host organism.


go_id: GO:0032539
term: negative regulation of host-seeking behavior
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of any behavior associated with finding a host organism.


go_id: GO:0032540
term: positive regulation of host-seeking behavior
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of any behavior associated with finding a host organism.


go_id: GO:0032541
term: cortical endoplasmic reticulum
ontology: CC
definition:
A cortical network of highly dynamic tubules that are juxtaposed to the plasma membrane and undergo ring closure and tubule-branching movements.


go_id: GO:0032542
term: sulfiredoxin activity
ontology: MF
definition:
Catalysis of the reaction: peroxiredoxin-(S-hydroxy-S-oxocysteine) + ATP + 2 R-SH = peroxiredoxin-(S-hydroxycysteine) + ADP + phosphate + R-S-S-R.


go_id: GO:0032543
term: mitochondrial translation
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of a protein in a mitochondrion. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the mitochondrion has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.


go_id: GO:0032544
term: plastid translation
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of a protein in a plastid. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein; the plastid has its own ribosomes and transfer RNAs, and uses a genetic code that differs from the nuclear code.


go_id: GO:0032545
term: CURI complex
ontology: CC
definition:
A protein complex that is involved in the transcription of ribosomal genes. In Saccharomyces this complex consists of Ckb2p, Utp22p, Rrp7p and Ifh1p.


go_id: GO:0032546
term: deoxyribonucleoside binding
ontology: MF
definition:
Binding to a deoxyribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to deoxyribose.


go_id: GO:0032547
term: purine deoxyribonucleoside binding
ontology: MF
definition:
Binding to a purine deoxyribonucleoside, a compound consisting of a purine base linked to deoxyribose.


go_id: GO:0032548
term: pyrimidine deoxyribonucleoside binding
ontology: MF
definition:
Binding to a pyrimidine deoxyribonucleoside, a compound consisting of a pyrimidine base linked to deoxyribose.


go_id: GO:0032549
term: ribonucleoside binding
ontology: MF
definition:
Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose.


go_id: GO:0032551
term: pyrimidine ribonucleoside binding
ontology: MF
definition:
Binding to a pyrimidine ribonucleoside, a compound consisting of a pyrimidine base linked to ribose.


go_id: GO:0032552
term: deoxyribonucleotide binding
ontology: MF
definition:
Binding to a deoxyribonucleotide, any compound consisting of a deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety.


go_id: GO:0032553
term: ribonucleotide binding
ontology: MF
definition:
Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.


go_id: GO:0032554
term: purine deoxyribonucleotide binding
ontology: MF
definition:
Binding to a purine deoxyribonucleotide, any compound consisting of a purine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety.


go_id: GO:0032555
term: purine ribonucleotide binding
ontology: MF
definition:
Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.


go_id: GO:0032556
term: pyrimidine deoxyribonucleotide binding
ontology: MF
definition:
Binding to a pyrimidine deoxyribonucleotide, any compound consisting of a pyrimidine deoxyribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety.


go_id: GO:0032557
term: pyrimidine ribonucleotide binding
ontology: MF
definition:
Binding to a pyrimidine ribonucleotide, any compound consisting of a pyrimidine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.


go_id: GO:0032558
term: adenyl deoxyribonucleotide binding
ontology: MF
definition:
Binding to an adenyl deoxyribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety.


go_id: GO:0032559
term: adenyl ribonucleotide binding
ontology: MF
definition:
Binding to an adenyl ribonucleotide, any compound consisting of adenosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.


go_id: GO:0032560
term: guanyl deoxyribonucleotide binding
ontology: MF
definition:
Binding to a guanyl deoxyribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the deoxyribose moiety.


go_id: GO:0032561
term: guanyl ribonucleotide binding
ontology: MF
definition:
Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.


go_id: GO:0032570
term: response to progesterone
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a progesterone stimulus.


go_id: GO:0032571
term: response to vitamin K
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin K stimulus.


go_id: GO:0032572
term: response to menaquinone
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menaquinone (vitamin K2) stimulus.


go_id: GO:0032573
term: response to phylloquinone
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a phylloquinone (vitamin K1) stimulus.


go_id: GO:0032576
term: O-linoleoyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group to an oxygen atom on the acceptor molecule.


go_id: GO:0032577
term: phosphatidylcholine:cardiolipin O-linoleoyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a linoleoyl ((9Z,12Z)-octadeca-9,12-dienoyl) group from phosphatidylcholine to an oxygen atom on a cardiolipin molecule.


go_id: GO:0032579
term: apical lamina of hyaline layer
ontology: CC
definition:
A fibrous network that is part of the hyalin layer extracellular matrix. The apical lamina is thought to be principally composed of the glycoproteins fibropellins. This matrix has been found in echinoderms.


go_id: GO:0032580
term: Golgi cisterna membrane
ontology: CC
definition:
The lipid bilayer surrounding any of the thin, flattened compartments that form the central portion of the Golgi complex.


go_id: GO:0032581
term: ER-dependent peroxisome organization
ontology: BP
definition:
A process of peroxisome organization in which assembly or arrangement of constituent parts takes place in the endoplasmic reticulum.


go_id: GO:0032592
term: integral component of mitochondrial membrane
ontology: CC
definition:
The component of the mitochondrial membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0032593
term: insulin-responsive compartment
ontology: CC
definition:
A small membrane-bounded vesicle that releases its contents by exocytosis in response to insulin stimulation; the contents are enriched in GLUT4, IRAP and VAMP2.


go_id: GO:0032596
term: protein transport into membrane raft
ontology: BP
definition:
The directed movement of a protein into a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.


go_id: GO:0032599
term: protein transport out of membrane raft
ontology: BP
definition:
The directed movement of a protein out of a membrane raft. Membrane rafts are small (10-200 nm), heterogeneous, highly dynamic, sterol- and sphingolipid-enriched membrane domains that compartmentalize cellular processes.


go_id: GO:0032601
term: connective tissue growth factor production
ontology: BP
definition:
The appearance of connective tissue growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032602
term: chemokine production
ontology: BP
definition:
The appearance of a chemokine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. All chemokines possess a number of conserved cysteine residues involved in intramolecular disulfide bond formation. Some chemokines are considered pro-inflammatory and can be induced during an immune response to recruit cells of the immune system to a site of infection, while others are considered homeostatic and are involved in controlling the migration of cells during normal processes of tissue maintenance or development. Chemokines are found in all vertebrates, some viruses and some bacteria.


go_id: GO:0032603
term: fractalkine production
ontology: BP
definition:
The appearance of fractalkine due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032604
term: granulocyte macrophage colony-stimulating factor production
ontology: BP
definition:
The appearance of granulocyte macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032605
term: hepatocyte growth factor production
ontology: BP
definition:
The appearance of hepatocyte growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032606
term: type I interferon production
ontology: BP
definition:
The appearance of type I interferon due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


go_id: GO:0032607
term: interferon-alpha production
ontology: BP
definition:
The appearance of interferon-alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032608
term: interferon-beta production
ontology: BP
definition:
The appearance of interferon-beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032609
term: interferon-gamma production
ontology: BP
definition:
The appearance of interferon-gamma due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Interferon-gamma is also known as type II interferon.


go_id: GO:0032610
term: interleukin-1 alpha production
ontology: BP
definition:
The appearance of interleukin-1 alpha due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032611
term: interleukin-1 beta production
ontology: BP
definition:
The appearance of interleukin-1 beta due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032612
term: interleukin-1 production
ontology: BP
definition:
The appearance of interleukin-1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032613
term: interleukin-10 production
ontology: BP
definition:
The appearance of interleukin-10 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032614
term: interleukin-11 production
ontology: BP
definition:
The appearance of interleukin-11 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032615
term: interleukin-12 production
ontology: BP
definition:
The appearance of interleukin-12 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032616
term: interleukin-13 production
ontology: BP
definition:
The appearance of interleukin-13 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032618
term: interleukin-15 production
ontology: BP
definition:
The appearance of interleukin-15 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032619
term: interleukin-16 production
ontology: BP
definition:
The appearance of interleukin-16 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032620
term: interleukin-17 production
ontology: BP
definition:
The appearance of any member of the interleukin-17 family of cytokines due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032621
term: interleukin-18 production
ontology: BP
definition:
The appearance of interleukin-18 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032622
term: interleukin-19 production
ontology: BP
definition:
The appearance of interleukin-19 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032623
term: interleukin-2 production
ontology: BP
definition:
The appearance of interleukin-2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032624
term: interleukin-20 production
ontology: BP
definition:
The appearance of interleukin-20 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032625
term: interleukin-21 production
ontology: BP
definition:
The appearance of interleukin-21 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032626
term: interleukin-22 production
ontology: BP
definition:
The appearance of interleukin-22 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032627
term: interleukin-23 production
ontology: BP
definition:
The appearance of interleukin-23 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032628
term: interleukin-24 production
ontology: BP
definition:
The appearance of interleukin-24 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032629
term: interleukin-25 production
ontology: BP
definition:
The appearance of interleukin-25 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032630
term: interleukin-26 production
ontology: BP
definition:
The appearance of interleukin-26 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032631
term: interleukin-27 production
ontology: BP
definition:
The appearance of interleukin-27 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032632
term: interleukin-3 production
ontology: BP
definition:
The appearance of interleukin-3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032633
term: interleukin-4 production
ontology: BP
definition:
The appearance of interleukin-4 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032634
term: interleukin-5 production
ontology: BP
definition:
The appearance of interleukin-5 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032635
term: interleukin-6 production
ontology: BP
definition:
The appearance of interleukin-6 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032636
term: interleukin-7 production
ontology: BP
definition:
The appearance of interleukin-7 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032637
term: interleukin-8 production
ontology: BP
definition:
The appearance of interleukin-8 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032638
term: interleukin-9 production
ontology: BP
definition:
The appearance of interleukin-9 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032639
term: TRAIL production
ontology: BP
definition:
The appearance of TRAIL due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032640
term: tumor necrosis factor production
ontology: BP
definition:
The appearance of tumor necrosis factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Tumor necrosis factor is an inflammatory cytokine produced by macrophages/monocytes during acute inflammation and which is responsible for a diverse range of signaling events within cells, leading to necrosis or apoptosis.


go_id: GO:0032643
term: regulation of connective tissue growth factor production
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of connective tissue growth factor production.


go_id: GO:0032645
term: regulation of granulocyte macrophage colony-stimulating factor production
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.


go_id: GO:0032649
term: regulation of interferon-gamma production
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.


go_id: GO:0032660
term: regulation of interleukin-17 production
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.


go_id: GO:0032682
term: negative regulation of chemokine production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of chemokine production.


go_id: GO:0032683
term: negative regulation of connective tissue growth factor production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of connective tissue growth factor production.


go_id: GO:0032684
term: negative regulation of fractalkine production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of fractalkine production.


go_id: GO:0032685
term: negative regulation of granulocyte macrophage colony-stimulating factor production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.


go_id: GO:0032686
term: negative regulation of hepatocyte growth factor production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of hepatocyte growth factor production.


go_id: GO:0032687
term: negative regulation of interferon-alpha production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-alpha production.


go_id: GO:0032688
term: negative regulation of interferon-beta production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-beta production.


go_id: GO:0032689
term: negative regulation of interferon-gamma production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.


go_id: GO:0032690
term: negative regulation of interleukin-1 alpha production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 alpha production.


go_id: GO:0032691
term: negative regulation of interleukin-1 beta production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 beta production.


go_id: GO:0032692
term: negative regulation of interleukin-1 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-1 production.


go_id: GO:0032693
term: negative regulation of interleukin-10 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-10 production.


go_id: GO:0032694
term: negative regulation of interleukin-11 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-11 production.


go_id: GO:0032695
term: negative regulation of interleukin-12 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-12 production.


go_id: GO:0032696
term: negative regulation of interleukin-13 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-13 production.


go_id: GO:0032698
term: negative regulation of interleukin-15 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-15 production.


go_id: GO:0032699
term: negative regulation of interleukin-16 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-16 production.


go_id: GO:0032700
term: negative regulation of interleukin-17 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.


go_id: GO:0032701
term: negative regulation of interleukin-18 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-18 production.


go_id: GO:0032702
term: negative regulation of interleukin-19 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-19 production.


go_id: GO:0032703
term: negative regulation of interleukin-2 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-2 production.


go_id: GO:0032704
term: negative regulation of interleukin-20 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-20 production.


go_id: GO:0032705
term: negative regulation of interleukin-21 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-21 production.


go_id: GO:0032706
term: negative regulation of interleukin-22 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-22 production.


go_id: GO:0032707
term: negative regulation of interleukin-23 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-23 production.


go_id: GO:0032708
term: negative regulation of interleukin-24 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-24 production.


go_id: GO:0032709
term: negative regulation of interleukin-25 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-25 production.


go_id: GO:0032710
term: negative regulation of interleukin-26 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-26 production.


go_id: GO:0032711
term: negative regulation of interleukin-27 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-27 production.


go_id: GO:0032712
term: negative regulation of interleukin-3 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-3 production.


go_id: GO:0032713
term: negative regulation of interleukin-4 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-4 production.


go_id: GO:0032714
term: negative regulation of interleukin-5 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-5 production.


go_id: GO:0032715
term: negative regulation of interleukin-6 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-6 production.


go_id: GO:0032716
term: negative regulation of interleukin-7 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-7 production.


go_id: GO:0032717
term: negative regulation of interleukin-8 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-8 production.


go_id: GO:0032718
term: negative regulation of interleukin-9 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of interleukin-9 production.


go_id: GO:0032720
term: negative regulation of tumor necrosis factor production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of tumor necrosis factor production.


go_id: GO:0032721
term: negative regulation of lymphotoxin A production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of lymphotoxin A production.


go_id: GO:0032723
term: positive regulation of connective tissue growth factor production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of connective tissue growth factor production.


go_id: GO:0032725
term: positive regulation of granulocyte macrophage colony-stimulating factor production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of granulocyte macrophage colony-stimulating factor production.


go_id: GO:0032726
term: positive regulation of hepatocyte growth factor production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of hepatocyte growth factor production.


go_id: GO:0032727
term: positive regulation of interferon-alpha production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interferon-alpha production.


go_id: GO:0032728
term: positive regulation of interferon-beta production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interferon-beta production.


go_id: GO:0032729
term: positive regulation of interferon-gamma production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interferon-gamma production. Interferon-gamma is also known as type II interferon.


go_id: GO:0032730
term: positive regulation of interleukin-1 alpha production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-1 alpha production.


go_id: GO:0032731
term: positive regulation of interleukin-1 beta production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-1 beta production.


go_id: GO:0032733
term: positive regulation of interleukin-10 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-10 production.


go_id: GO:0032734
term: positive regulation of interleukin-11 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-11 production.


go_id: GO:0032735
term: positive regulation of interleukin-12 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-12 production.


go_id: GO:0032736
term: positive regulation of interleukin-13 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-13 production.


go_id: GO:0032738
term: positive regulation of interleukin-15 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-15 production.


go_id: GO:0032739
term: positive regulation of interleukin-16 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-16 production.


go_id: GO:0032740
term: positive regulation of interleukin-17 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of production of any member of the interleukin-17 family of cytokines.


go_id: GO:0032741
term: positive regulation of interleukin-18 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-18 production.


go_id: GO:0032742
term: positive regulation of interleukin-19 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-19 production.


go_id: GO:0032744
term: positive regulation of interleukin-20 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-20 production.


go_id: GO:0032745
term: positive regulation of interleukin-21 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-21 production.


go_id: GO:0032746
term: positive regulation of interleukin-22 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-22 production.


go_id: GO:0032747
term: positive regulation of interleukin-23 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-23 production.


go_id: GO:0032748
term: positive regulation of interleukin-24 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-24 production.


go_id: GO:0032749
term: positive regulation of interleukin-25 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-25 production.


go_id: GO:0032750
term: positive regulation of interleukin-26 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-26 production.


go_id: GO:0032751
term: positive regulation of interleukin-27 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of interleukin-27 production.


go_id: GO:0032760
term: positive regulation of tumor necrosis factor production
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of tumor necrosis factor production.


go_id: GO:0032764
term: negative regulation of mast cell cytokine production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell cytokine production.


go_id: GO:0032765
term: positive regulation of mast cell cytokine production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of mast cell cytokine production.


go_id: GO:0032766
term: NHE3/E3KARP/ACTN4 complex
ontology: CC
definition:
A heterotrimeric protein complex formed by the association of NHE3, E3KARP and alpha-actinin upon an increase in calcium ion concentration; found in clusters localized on plasma membrane and in intracellular compartments.


go_id: GO:0032774
term: RNA biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of RNA, ribonucleic acid, one of the two main type of nucleic acid, consisting of a long, unbranched macromolecule formed from ribonucleotides joined in 3',5'-phosphodiester linkage. Includes polymerization of ribonucleotide monomers. Refers not only to transcription but also to e.g. viral RNA replication.


go_id: GO:0032777
term: Piccolo NuA4 histone acetyltransferase complex
ontology: CC
definition:
A heterotrimeric H4/H2A histone acetyltransferase complex with a substrate preference of chromatin over free histones. It contains a subset of the proteins found in the larger NuA4 histone acetyltransferase complex; for example, the S. cerevisiae complex contains Esa1p, Yng2p, and Epl1p.


go_id: GO:0032778
term: P-type cobalt transporter activity
ontology: MF
definition:
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + cobalt(out) = ADP + phosphate + cobalt(in).


go_id: GO:0032782
term: bile acid secretion
ontology: BP
definition:
The regulated release of bile acid, composed of any of a group of steroid carboxylic acids occurring in bile, by a cell or a tissue.


go_id: GO:0032783
term: super elongation complex
ontology: CC
definition:
A transcription elongation factor complex that increases the overall rate of RNA polymerase II transcription elongation by suppressing transient polymerase pausing. At minimum, the complex contains a transcription factor of the ELL family, an EAF protein, and an AFF family protein or distant relative and most likely also P-TEFb and AF9 or ENL. The complex is conserved from yeast to humans. In Schizosaccharomyces pombe it contains Ell1, Eaf1, and Ebp1, but it is absent from S. cerevisiae.


go_id: GO:0032784
term: regulation of DNA-templated transcription elongation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.


go_id: GO:0032785
term: negative regulation of DNA-templated transcription, elongation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.


go_id: GO:0032786
term: positive regulation of DNA-templated transcription, elongation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides catalyzed by a DNA-dependent RNA polymerase.


go_id: GO:0032787
term: monocarboxylic acid metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).


go_id: GO:0032788
term: saturated monocarboxylic acid metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving saturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and fully saturated C-C bonds.


go_id: GO:0032789
term: unsaturated monocarboxylic acid metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving unsaturated monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-) and one or more unsaturated C-C bonds.


go_id: GO:0032790
term: ribosome disassembly
ontology: BP
definition:
The disaggregation of a ribosome into its constituent components; includes the dissociation of ribosomal subunits.


go_id: GO:0032792
term: negative regulation of CREB transcription factor activity
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of the transcription factor CREB.


go_id: GO:0032793
term: positive regulation of CREB transcription factor activity
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of activity of the transcription factor CREB.


go_id: GO:0032796
term: uropod organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a uropod, a rigid membrane projection with related cytoskeletal components at the trailing edge of a lymphocyte or other cell in the process of migrating or being activated.


go_id: GO:0032797
term: SMN complex
ontology: CC
definition:
A protein complex that contains the survival motor neuron (SMN) protein and at least eight additional integral components, including the Gemin2-8 and Unrip proteins; the complex is found in the cytoplasm and in nuclear Gems, and is involved in spliceosomal snRNP assembly in the cytoplasm and in pre-mRNA splicing in the nucleus.


go_id: GO:0032798
term: Swi5-Sfr1 complex
ontology: CC
definition:
A conserved DNA recombinase mediator complex that contains two Swi5 monomers and one Sfr1 monomer in Schizosaccharomyces, or orthologs thereof (e.g. Sae3p and Mei5p in Saccharomyces).


go_id: GO:0032801
term: receptor catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.


go_id: GO:0032802
term: low-density lipoprotein particle receptor catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a low-density lipoprotein particle receptor molecule, a macromolecule that undergoes combination with a hormone, neurotransmitter, drug or intracellular messenger to initiate a change in cell function.


go_id: GO:0032803
term: regulation of low-density lipoprotein particle receptor catabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors.


go_id: GO:0032804
term: negative regulation of low-density lipoprotein particle receptor catabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein receptors.


go_id: GO:0032805
term: positive regulation of low-density lipoprotein particle receptor catabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of low-density lipoprotein particle receptors.


go_id: GO:0032806
term: carboxy-terminal domain protein kinase complex
ontology: CC
definition:
A protein complex that phosphorylates amino acid residues of RNA polymerase II C-terminal domain repeats; phosphorylation occurs mainly on Ser2 and Ser5.


go_id: GO:0032807
term: DNA ligase IV complex
ontology: CC
definition:
A eukaryotically conserved protein complex that contains DNA ligase IV and is involved in DNA repair by non-homologous end joining; in addition to the ligase, the complex also contains XRCC4 or a homolog, e.g. Saccharomyces Lif1p.


go_id: GO:0032808
term: lacrimal gland development
ontology: BP
definition:
The process whose specific outcome is the progression of the lacrimal gland over time, from its formation to the mature structure. The lacrimal gland produces secretions that lubricate and protect the cornea of the eye.


go_id: GO:0032809
term: neuronal cell body membrane
ontology: CC
definition:
The plasma membrane of a neuron cell body - excludes the plasma membrane of cell projections such as axons and dendrites.


go_id: GO:0032810
term: sterol response element binding
ontology: MF
definition:
Binding to a sterol response element (SRE), a nonpalindromic sequence found in the promoters of genes involved in lipid metabolism.


go_id: GO:0032811
term: negative regulation of epinephrine secretion
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the regulated release of epinephrine.


go_id: GO:0032812
term: positive regulation of epinephrine secretion
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the regulated release of epinephrine.


go_id: GO:0032815
term: negative regulation of natural killer cell activation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation.


go_id: GO:0032816
term: positive regulation of natural killer cell activation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of natural killer cell activation.


go_id: GO:0032818
term: negative regulation of natural killer cell proliferation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation.


go_id: GO:0032819
term: positive regulation of natural killer cell proliferation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation.


go_id: GO:0032820
term: regulation of natural killer cell proliferation involved in immune response
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of natural killer cell proliferation as part of an immune response.


go_id: GO:0032821
term: negative regulation of natural killer cell proliferation involved in immune response
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell proliferation as part of an immune response.


go_id: GO:0032822
term: positive regulation of natural killer cell proliferation involved in immune response
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of natural killer cell proliferation as part of an immune response.


go_id: GO:0032824
term: negative regulation of natural killer cell differentiation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation.


go_id: GO:0032825
term: positive regulation of natural killer cell differentiation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation.


go_id: GO:0032826
term: regulation of natural killer cell differentiation involved in immune response
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of natural killer cell differentiation as part of an immune response.


go_id: GO:0032827
term: negative regulation of natural killer cell differentiation involved in immune response
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of natural killer cell differentiation as part of an immune response.


go_id: GO:0032828
term: positive regulation of natural killer cell differentiation involved in immune response
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of natural killer cell differentiation as part of an immune response.


go_id: GO:0032829
term: regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells.


go_id: GO:0032830
term: negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells.


go_id: GO:0032831
term: positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells.


go_id: GO:0032832
ontology: BP
term:
regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

definition:
Any process that modulates the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response.


go_id: GO:0032833
ontology: BP
term:
negative regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response.


go_id: GO:0032834
ontology: BP
term:
positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response

definition:
Any process that activates or increases the frequency, rate or extent of differentiation of CD4-positive, CD25-positive, alpha-beta regulatory T cells as part of an immune response.


go_id: GO:0032835
term: glomerulus development
ontology: BP
definition:
The progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft which forms a close network with the visceral epithelium (podocytes) and the mesangium to form the filtration barrier and is surrounded by Bowman's capsule in nephrons of the vertebrate kidney. The glomerulus is part of the nephron and is restricted to one body segment.


go_id: GO:0032836
term: glomerular basement membrane development
ontology: BP
definition:
The process whose specific outcome is the progression of the glomerular basement membrane over time, from its formation to the mature structure. The glomerular basement membrane is the basal laminal portion of the glomerulus which performs the actual filtration.


go_id: GO:0032837
term: distributive segregation
ontology: BP
definition:
The cell cycle process in which genetic material, in the form of chromosomes, is organized and then physically separated and apportioned to two or more sets during a normally chiasmate meiosis under the condition that chiasma have not occurred between a particular pair of homologs. Distributive segregation is a backup mechanism to ensure the segregation of homologs that have failed to cross over - either as a consequence of mutation or not, as, for example, the 4th chromosome of Drosophila melanogaster (which never exchanges, presumably due to its small size) - but nevertheless segregate normally.


go_id: GO:0032838
term: plasma membrane bounded cell projection cytoplasm
ontology: CC
definition:
All of the contents of a plasma membrane bounded cell projection, excluding the plasma membrane surrounding the projection.


go_id: GO:0032841
term: calcitonin binding
ontology: MF
definition:
Binding to calcitonin, a peptide hormone responsible for reducing serum calcium levels by inhibiting osteoclastic bone reabsorption and promoting renal calcium excretion. It is synthesized and released by the C cells of the thyroid.


go_id: GO:0032843
term: hydroperoxide reductase activity
ontology: MF
definition:
Catalysis of the reaction: 2 RSH + ROOH = RSSR + ROH + H2O. This reaction is the thiol-dependent conversion of an organic hydroperoxide to the corresponding alcohol.


go_id: GO:0032847
term: regulation of cellular pH reduction
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of a process that reduces the internal pH of a cell.


go_id: GO:0032848
term: negative regulation of cellular pH reduction
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of a process that reduces the internal pH of a cell.


go_id: GO:0032849
term: positive regulation of cellular pH reduction
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of a process that reduces the internal pH of a cell.


go_id: GO:0032865
term: ERMES complex
ontology: CC
definition:
A protein complex that links the endoplasmic reticulum with mitochondria and may have a role in promoting exchange of calcium and phospholipids between the two organelles.


go_id: GO:0032868
term: response to insulin
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.


go_id: GO:0032869
term: cellular response to insulin stimulus
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an insulin stimulus. Insulin is a polypeptide hormone produced by the islets of Langerhans of the pancreas in mammals, and by the homologous organs of other organisms.


go_id: GO:0032870
term: cellular response to hormone stimulus
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hormone stimulus.


go_id: GO:0032871
term: regulation of karyogamy
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of karyogamy, the creation of a single nucleus from multiple nuclei as a result of membrane fusion.


go_id: GO:0032872
term: regulation of stress-activated MAPK cascade
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.


go_id: GO:0032873
term: negative regulation of stress-activated MAPK cascade
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.


go_id: GO:0032874
term: positive regulation of stress-activated MAPK cascade
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of signal transduction mediated by the stress-activated MAPK cascade.


go_id: GO:0032876
term: negative regulation of DNA endoreduplication
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of DNA endoreduplication.


go_id: GO:0032878
term: regulation of establishment or maintenance of cell polarity
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the specification, formation or maintenance of anisotropic intracellular organization or cell growth patterns.


go_id: GO:0032879
term: regulation of localization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of any process in which a cell, a substance, or a cellular entity is transported to, or maintained in, a specific location.


go_id: GO:0032880
term: regulation of protein localization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of any process in which a protein is transported to, or maintained in, a specific location.


go_id: GO:0032881
term: regulation of polysaccharide metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving polysaccharides.


go_id: GO:0032882
term: regulation of chitin metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chitin.


go_id: GO:0032883
term: regulation of chitin biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of chitin.


go_id: GO:0032884
term: regulation of cell wall chitin biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of cell wall chitin.


go_id: GO:0032885
term: regulation of polysaccharide biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of polysaccharides.


go_id: GO:0032886
term: regulation of microtubule-based process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the microtubule cytoskeleton.


go_id: GO:0032887
term: regulation of spindle elongation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the spindle.


go_id: GO:0032888
term: regulation of mitotic spindle elongation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the cell cycle process in which the distance is lengthened between poles of the mitotic spindle.


go_id: GO:0032889
term: regulation of vacuole fusion, non-autophagic
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the fusion of two vacuole membranes to form a single vacuole.


go_id: GO:0032890
term: regulation of organic acid transport
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032891
term: negative regulation of organic acid transport
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032892
term: positive regulation of organic acid transport
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the directed movement of organic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0032898
term: neurotrophin production
ontology: BP
definition:
The appearance of a neurotrophin due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels. A neurotrophin is any of a family of growth factors that prevent apoptosis in neurons and promote nerve growth.


go_id: GO:0032900
term: negative regulation of neurotrophin production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of a neurotrophin.


go_id: GO:0032901
term: positive regulation of neurotrophin production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of production of a neurotrophin.


go_id: GO:0032902
term: nerve growth factor production
ontology: BP
definition:
The appearance of nerve growth factor (NGF) due to biosynthesis or secretion by cells in a neuron's target field, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032903
term: regulation of nerve growth factor production
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of production of nerve growth factor (NGF).


go_id: GO:0032904
term: negative regulation of nerve growth factor production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of nerve growth factor (NGF).


go_id: GO:0032905
term: transforming growth factor beta1 production
ontology: BP
definition:
The appearance of transforming growth factor-beta1 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032906
term: transforming growth factor beta2 production
ontology: BP
definition:
The appearance of transforming growth factor-beta2 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032907
term: transforming growth factor beta3 production
ontology: BP
definition:
The appearance of transforming growth factor-beta3 due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0032908
term: regulation of transforming growth factor beta1 production
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta1.


go_id: GO:0032909
term: regulation of transforming growth factor beta2 production
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta2.


go_id: GO:0032910
term: regulation of transforming growth factor beta3 production
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of production of transforming growth factor-beta3.


go_id: GO:0032911
term: negative regulation of transforming growth factor beta1 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta1.


go_id: GO:0032912
term: negative regulation of transforming growth factor beta2 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta2.


go_id: GO:0032913
term: negative regulation of transforming growth factor beta3 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of transforming growth factor-beta3.


go_id: GO:0032914
term: positive regulation of transforming growth factor beta1 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta1.


go_id: GO:0032915
term: positive regulation of transforming growth factor beta2 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta2.


go_id: GO:0032916
term: positive regulation of transforming growth factor beta3 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of production of transforming growth factor-beta3.


go_id: GO:0032921
term: sarcosine oxidase complex
ontology: CC
definition:
A complex consisting of 4 protein subunits as a heterotetramer, that possesses sarcosine oxidase activity.


go_id: GO:0032922
term: circadian regulation of gene expression
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of gene expression such that an expression pattern recurs with a regularity of approximately 24 hours.


go_id: GO:0032923
term: organic phosphonate biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Synthesis of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.


go_id: GO:0032924
term: activin receptor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by an extracellular ligand binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0032925
term: regulation of activin receptor signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the activity of any activin receptor signaling pathway.


go_id: GO:0032926
term: negative regulation of activin receptor signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any activin receptor signaling pathway.


go_id: GO:0032927
term: positive regulation of activin receptor signaling pathway
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the activity of any activin receptor signaling pathway.


go_id: GO:0032928
term: regulation of superoxide anion generation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of enzymatic generation of superoxide by a cell.


go_id: GO:0032929
term: negative regulation of superoxide anion generation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of enzymatic generation of superoxide by a cell.


go_id: GO:0032930
term: positive regulation of superoxide anion generation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of enzymatic generation of superoxide by a cell.


go_id: GO:0032931
term: histone acetyltransferase activity (H3-K56 specific)
ontology: MF
definition:
Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 56) = CoA + histone H3 N6-acetyl-L-lysine (position 56).


go_id: GO:0032932
term: negative regulation of astral microtubule depolymerization
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the depolymerization of astral microtubules.


go_id: GO:0032933
term: SREBP signaling pathway
ontology: BP
definition:
The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.


go_id: GO:0032934
term: sterol binding
ontology: MF
definition:
Binding to a sterol, a steroid containing a hydroxy group in the 3 position, closely related to cholestan-3-ol.


go_id: GO:0032935
term: sterol sensor activity
ontology: MF
definition:
Binding to and responding, e.g. by conformational change, to changes in the cellular level of a sterol.


go_id: GO:0032936
term: SREBP-SCAP complex
ontology: CC
definition:
A protein complex formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP) in the ER membrane; in the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed.


go_id: GO:0032937
term: SREBP-SCAP-Insig complex
ontology: CC
definition:
A protein complex formed by the association of sterol regulatory element binding protein (SREBP), SREBP-cleavage-activating protein (SCAP), and an Insig protein (Insig-1 or Insig-2) in the ER membrane.


go_id: GO:0032938
term: negative regulation of translation in response to oxidative stress
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


go_id: GO:0032939
term: positive regulation of translation in response to oxidative stress
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of translation as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


go_id: GO:0032942
term: inositol tetrakisphosphate 2-kinase activity
ontology: MF
definition:
Catalysis of the reaction: 1D-myo-inositol tetrakisphosphate + ATP = 1D-myo-inositol pentakisphosphate (containing 2-phosphate) + ADP.


go_id: GO:0032943
term: mononuclear cell proliferation
ontology: BP
definition:
The expansion of a mononuclear cell population by cell division. A mononuclear cell is a leukocyte with a single non-segmented nucleus in the mature form.


go_id: GO:0032945
term: negative regulation of mononuclear cell proliferation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of mononuclear cell proliferation.


go_id: GO:0032946
term: positive regulation of mononuclear cell proliferation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of mononuclear cell proliferation.


go_id: GO:0032948
term: regulation of alpha-glucan metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving alpha-glucans.


go_id: GO:0032949
term: regulation of alpha-glucan biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of alpha-glucans.


go_id: GO:0032950
term: regulation of beta-glucan metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving beta-glucans.


go_id: GO:0032951
term: regulation of beta-glucan biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways relusting in the formation of beta-glucans.


go_id: GO:0032952
term: regulation of (1->3)-beta-D-glucan metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving (1->3)-beta-D-glucans.


go_id: GO:0032953
term: regulation of (1->3)-beta-D-glucan biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans.


go_id: GO:0032955
term: regulation of division septum assembly
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of division septum formation. Division septum formation is the assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis.


go_id: GO:0032956
term: regulation of actin cytoskeleton organization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.


go_id: GO:0032957
term: inositol trisphosphate metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving myo-inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.


go_id: GO:0032958
term: inositol phosphate biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of an inositol phosphate, 1,2,3,4,5,6-cyclohexanehexol, with one or more phosphate groups attached.


go_id: GO:0032959
term: inositol trisphosphate biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of inositol trisphosphate, 1,2,3,4,5,6-cyclohexanehexol, with three phosphate groups attached.


go_id: GO:0032960
term: regulation of inositol trisphosphate biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.


go_id: GO:0032961
term: negative regulation of inositol trisphosphate biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.


go_id: GO:0032962
term: positive regulation of inositol trisphosphate biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of inositol trisphosphate.


go_id: GO:0032963
term: collagen metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).


go_id: GO:0032964
term: collagen biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals. Collagen is highly enriched in glycine (some regions are 33% glycine) and proline, occurring predominantly as 3-hydroxyproline (about 20%).


go_id: GO:0032965
term: regulation of collagen biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.


go_id: GO:0032966
term: negative regulation of collagen biosynthetic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.


go_id: GO:0032967
term: positive regulation of collagen biosynthetic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of collagen, any of a group of fibrous proteins of very high tensile strength that form the main component of connective tissue in animals.


go_id: GO:0032968
term: positive regulation of transcription elongation by RNA polymerase II
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of transcription elongation, the extension of an RNA molecule after transcription initiation and promoter clearance by the addition of ribonucleotides, catalyzed by RNA polymerase II.


go_id: GO:0032969
term: endosomal scaffold complex
ontology: CC
definition:
A protein complex that contains MAPKSP1 (MP1, Map2k1ip1) and ROBLD3 (p14, Mapbpip), is anchored to late endosomes, and is involved in selective activation of the ERK1 in ERK/MAPK signaling.


go_id: GO:0032970
term: regulation of actin filament-based process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of any cellular process that depends upon or alters the actin cytoskeleton.


go_id: GO:0032973
term: amino acid export across plasma membrane
ontology: BP
definition:
The directed movement of amino acids from inside of a cell, across the plasma membrane and into the extracellular region.


go_id: GO:0032976
term: release of matrix enzymes from mitochondria
ontology: BP
definition:
The process in which enzymes, such as aspartate aminotransferase, are enabled to move from the mitochondrial matrix into the cytosol, as part of the apoptotic process.


go_id: GO:0032978
term: protein insertion into membrane from inner side
ontology: BP
definition:
The process in which a protein is incorporated into a lipid bilayer, e.g., the prokaryotic, mitochondrial, or chloroplast inner membrane, from the inner side.


go_id: GO:0032979
term: protein insertion into mitochondrial inner membrane from matrix
ontology: BP
definition:
The process in which a protein is incorporated into the mitochondrial inner membrane from the matrix side. This includes membrane insertion of newly synthesized mitochondrially-encoded proteins, and insertion of nuclear-encoded proteins after their import into the mitochondrial matrix.


go_id: GO:0032980
term: keratinocyte activation
ontology: BP
definition:
A change in the morphology or behavior of a keratinocyte resulting from exposure to an activating factor such as a cellular or soluble ligand. Upon activation, keratinocytes become migratory and hyperproliferative, and produce growth factors and cytokines.


go_id: GO:0032981
term: mitochondrial respiratory chain complex I assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form mitochondrial respiratory chain complex I.


go_id: GO:0032982
term: myosin filament
ontology: CC
definition:
A supramolecular fiber containing myosin heavy chains, plus associated light chains and other proteins, in which the myosin heavy chains are arranged into a filament.


go_id: GO:0032983
term: kainate selective glutamate receptor complex
ontology: CC
definition:
An assembly of four or five subunits which form a structure with an extracellular N-terminus and a large loop that together form the ligand binding domain. The C-terminus is intracellular. The ionotropic glutamate receptor complex itself acts as a ligand gated ion channel; on binding glutamate, charged ions pass through a channel in the center of the receptor complex. Kainate receptors are multimeric assemblies of GluK1-3 (also called GluR5-7), GluK4 (KA1) and GluK5 (KA2) subunits.


go_id: GO:0032989
term: cellular component morphogenesis
ontology: BP
definition:
The process in which cellular structures, including whole cells or cell parts, are generated and organized.


go_id: GO:0032991
term: protein-containing complex
ontology: CC
definition:
A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.


go_id: GO:0032992
term: protein-carbohydrate complex
ontology: CC
definition:
A macromolecular complex containing separate protein and carbohydrate molecules.  Separate in this context means not covalently bound to each other.


go_id: GO:0032994
term: protein-lipid complex
ontology: CC
definition:
A macromolecular complex containing separate protein and lipid molecules.  Separate in this context means not covalently bound to each other.


go_id: GO:0032995
term: regulation of fungal-type cell wall biogenesis
ontology: BP
definition:
Any process that modulates the process in which a cell wall is synthesized, aggregates, and bonds together. The fungal-type cell wall contains beta-glucan and may contain chitin.


go_id: GO:0032996
term: Bcl3-Bcl10 complex
ontology: CC
definition:
A protein complex containing Bcl3 and Bcl10, which forms when Akt1 is activated by TNF-alpha to phosphorylate Bcl10; the Bcl3-Bcl10 complex is translocated to the nucleus.


go_id: GO:0032997
term: Fc receptor complex
ontology: CC
definition:
A protein complex composed of a subunit or subunits capable of binding the Fc portion of an immunoglobulin with additional signaling components. The complex functions as a receptor for immunoglobulin.


go_id: GO:0032998
term: Fc-epsilon receptor I complex
ontology: CC
definition:
A protein complex composed of an Fc-epsilon RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-episilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgE.


go_id: GO:0032999
term: Fc-alpha receptor I complex
ontology: CC
definition:
A protein complex composed of an Fc-alpha R alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgA.


go_id: GO:0033000
term: Fc-gamma receptor I complex
ontology: CC
definition:
A protein complex composed of an Fc-gamma RI alpha chain and an Fc-epsilon RI gamma chain dimer with or without additional signaling components. The complex functions primarily as an activating receptor for IgG.


go_id: GO:0033001
term: Fc-gamma receptor III complex
ontology: CC
definition:
A protein complex composed of an Fc-gamma RIII alpha chain and an Fc-epsilon RI gamma chain dimer with or without an Fc-epsilon RI beta chain and additional signaling components. The complex functions primarily as an activating receptor for IgG.


go_id: GO:0033004
term: negative regulation of mast cell activation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation.


go_id: GO:0033006
term: regulation of mast cell activation involved in immune response
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of mast cell activation as part of an immune response.


go_id: GO:0033007
term: negative regulation of mast cell activation involved in immune response
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell activation as part of an immune response.


go_id: GO:0033008
term: positive regulation of mast cell activation involved in immune response
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of mast cell activation as part of an immune response.


go_id: GO:0033009
term: nucleomorph
ontology: CC
definition:
A small, vestigial nucleus found in some plastids that derive from a eukaryotic endosymbiont. Observed in chlorarachniophytes and cryptomonads, which acquired their plastids from a green and red alga respectively.


go_id: GO:0033010
term: paranodal junction
ontology: CC
definition:
A highly specialized cell-cell junction found in vertebrates, which forms between a neuron and a glial cell, and has structural similarity to Drosophila septate junctions. It flanks the node of Ranvier in myelinated nerve and electrically isolates the myelinated from unmyelinated nerve segments and physically separates the voltage-gated sodium channels at the node from the cluster of potassium channels underneath the myelin sheath.


go_id: GO:0033011
term: perinuclear theca
ontology: CC
definition:
A condensed cytoplasmic structure that covers the nucleus of mammalian spermatozoa except for a narrow zone around the insertion of the tail. It shows two distinct regions, a subacrosomal layer and, continuing caudally beyond the acrosomic system, the postacrosomal sheath. The perinuclear theca has been considered a cytoskeletal scaffold responsible for maintaining the overall architecture of the mature sperm head; however, recent studies indicate that the bulk of its constituent proteins are not traditional cytoskeletal proteins but rather a variety of cytosolic proteins.


go_id: GO:0033012
term: porosome
ontology: CC
definition:
A permanent cup-shaped structure at the cell plasma membrane in secretory cells. Following a secretory stimulus, secretory vesicles transiently dock and fuse at the base of porosomes and release intravesicular contents dictated by the turgor pressure generated from the swelling of secretory vesicles.


go_id: GO:0033013
term: tetrapyrrole metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.


go_id: GO:0033014
term: tetrapyrrole biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.


go_id: GO:0033015
term: tetrapyrrole catabolic process
ontology: BP
definition:
The chemical reactions and pathways leading to the breakdown of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next.


go_id: GO:0033023
term: mast cell homeostasis
ontology: BP
definition:
The process of regulating the proliferation and elimination of mast cells such that the total number of mast cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.


go_id: GO:0033024
term: mast cell apoptotic process
ontology: BP
definition:
Any apoptotic process in a mast cell, a cell that is found in almost all tissues containing numerous basophilic granules and capable of releasing large amounts of histamine and heparin upon activation.


go_id: GO:0033026
term: negative regulation of mast cell apoptotic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of mast cell apoptotic process.


go_id: GO:0033027
term: positive regulation of mast cell apoptotic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of mast cell apoptotic process.


go_id: GO:0033028
term: myeloid cell apoptotic process
ontology: BP
definition:
Any apoptotic process in a myeloid cell, a cell of the monocyte, granulocyte, mast cell, megakaryocyte, or erythroid lineage.


go_id: GO:0033030
term: negative regulation of neutrophil apoptotic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of neutrophil apoptotic process.


go_id: GO:0033031
term: positive regulation of neutrophil apoptotic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of neutrophil apoptotic process.


go_id: GO:0033033
term: negative regulation of myeloid cell apoptotic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of a myeloid cell apoptotic process.


go_id: GO:0033034
term: positive regulation of myeloid cell apoptotic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of myeloid cell apoptotic process.


go_id: GO:0033038
term: bitter taste receptor activity
ontology: MF
definition:
Combining with soluble bitter compounds to initiate a change in cell activity. These receptors are responsible for the sense of bitter taste.


go_id: GO:0033039
term: salty taste receptor activity
ontology: MF
definition:
Combining with soluble salty compounds to initiate a change in cell activity. These receptors are responsible for the sense of salty taste.


go_id: GO:0033040
term: sour taste receptor activity
ontology: MF
definition:
Combining with soluble sour compounds to initiate a change in cell activity. These receptors are responsible for the sense of sour taste.


go_id: GO:0033041
term: sweet taste receptor activity
ontology: MF
definition:
Combining with soluble sweet compounds to initiate a change in cell activity. These receptors are responsible for the sense of sweet taste.


go_id: GO:0033042
term: umami taste receptor activity
ontology: MF
definition:
Combining with soluble umami compounds to initiate a change in cell activity. These receptors are responsible for the sense of umami taste, the savory taste of meats and other foods that are rich in glutamates.


go_id: GO:0033043
term: regulation of organelle organization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of an organelle.


go_id: GO:0033044
term: regulation of chromosome organization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a process involved in the formation, arrangement of constituent parts, or disassembly of a chromosome.


go_id: GO:0033046
term: negative regulation of sister chromatid segregation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation.


go_id: GO:0033047
term: regulation of mitotic sister chromatid segregation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of sister chromatid segregation during mitosis.


go_id: GO:0033048
term: negative regulation of mitotic sister chromatid segregation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of sister chromatid segregation during mitosis.


go_id: GO:0033049
term: clavulanic acid metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.


go_id: GO:0033050
term: clavulanic acid biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of clavulanic acid, (2R,3Z,5R)-3-(2-hydroxyethylidene)-7-oxo-4-oxa-1-azabicyclo[3.2.0]heptane-2-carboxylic acid.


go_id: GO:0033051
term: aminophosphonate metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving aminophosphonates, phosphonic acid derivatives that contain an amino group.


go_id: GO:0033052
term: cyanoamino acid metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving cyanoamino acids, amino acid derivatives that contain a cyanide group.


go_id: GO:0033053
term: D-glutamine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving D-glutamine, the D-enantiomer of the amino acid glutamine, i.e. (2R)-2,5-diamino-5-oxopentanoic acid.


go_id: GO:0033054
term: D-glutamate metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving D-glutamate, the D-enantiomer of the amino acid glutamate, i.e. (2R)-2-aminopentanedioic acid.


go_id: GO:0033055
term: D-arginine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving D-arginine, the D-enantiomer of the amino acid arginine, i.e. (2R)-2-amino-5-(carbamimidamido)pentanoic acid.


go_id: GO:0033056
term: D-ornithine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving D-ornithine, the D-enantiomer of the amino acid ornithine, i.e. (2R)-2,5-diaminopentanoic acid.


go_id: GO:0033060
term: ocellus pigmentation
ontology: BP
definition:
The deposition or aggregation of coloring matter in an ocellus, a minute simple eye found in many invertebrates.


go_id: GO:0033061
term: DNA recombinase mediator complex
ontology: CC
definition:
A protein complex containing accessory proteins which bind a recombinase (e.g. Rad51) and bind single-stranded DNA (ssDNA), and promote nucleation of the recombinase onto ssDNA through facilitating recombinase-RPA exchange.


go_id: GO:0033062
term: Rhp55-Rhp57 complex
ontology: CC
definition:
A conserved heterodimeric DNA recombinase mediator complex that contains the RecA family proteins Rhp55p and Rph57 in Schizosaccharomyces, or orthologs thereof (e.g. Rad55p and Rad57p in Saccharomyces).


go_id: GO:0033063
term: Rad51B-Rad51C-Rad51D-XRCC2 complex
ontology: CC
definition:
A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B, RAD51C, RAD51D, and XRCC2, or orthologs thereof.


go_id: GO:0033064
term: XRCC2-RAD51D complex
ontology: CC
definition:
A heterodimeric DNA recombinase mediator complex that contains the Rad51 paralogs RAD51D and XRCC2, or orthologs thereof; conserved from fission yeast to human but absent from budding yeast.


go_id: GO:0033065
term: Rad51C-XRCC3 complex
ontology: CC
definition:
A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51C and XRCC3, or orthologs thereof.


go_id: GO:0033066
term: Rad51B-Rad51C complex
ontology: CC
definition:
A DNA recombinase mediator complex that contains the Rad51 paralogs RAD51B and RAD51C, or orthologs thereof.


go_id: GO:0033067
term: macrolide metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria.


go_id: GO:0033068
term: macrolide biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways leading to the formation of macrolides, any of a large group of polyketide compounds that contain a large lactone ring with few or no double bonds and no nitrogen atoms, linked glycosidically to one or more sugar groups. The macrolides include the carbomycins, the erythromycins, oleandomycin, oligomycins, and the spiramycins, and act as antibiotics, mainly against Gram-positive bacteria.


go_id: GO:0033069
term: ansamycin metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity.


go_id: GO:0033070
term: ansamycin biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways leading to the formation of ansamycins, any of a group of complex macrolactam compounds characterized by a cyclic structure in which an aliphatic ansa chain forms a bridge between two non-adjacent positions of a cyclic p-system; many exhibit antibacterial, antifungal or antitumor activity.


go_id: GO:0033071
term: vancomycin metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria.


go_id: GO:0033072
term: vancomycin biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways leading to the formation of vancomycin, (3S,6R,7R,11R,23S,26S,30aS,36R,38aR)-44-[2-O-(3-amino-2,3,6-trideoxy-3-C-methyl-alpha-L-lyxo-hexopyranosyl)-beta-D-glucopyranosyloxy]-3-(carbamoylmethyl)-10,19-dichloro-2,3,4,5,6,7,23,25,26,36,37,38,38a-tetradecahydro-7,22,28,30,32-pentahydroxy-6-(N-methyl-D-leucyl)-2,5,24,38,39-pentaoxo-1H,22H-23,36-(epiminomethano)-8,11:18,21-dietheno-13,16:31,35-di(metheno)[1,6,9]oxadiazacyclohexadecino[4,5-m][10,2,16]benzoxadiazacyclotetracosine-26-carboxylic acid, a complex glycopeptide from Streptomyces orientalis that inhibits a specific step in the synthesis of the peptidoglycan layer in Gram-positive bacteria.


go_id: GO:0033073
term: pinene metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane.


go_id: GO:0033074
term: pinene catabolic process
ontology: BP
definition:
The chemical reactions and pathways leading to the breakdown of the monoterpenoid pinene; alpha-pinene is (1S,5S)-2,6,6-trimethylbicyclo[3.1.1]hept-2-ene, and beta-pinene is (1S,5S)-6,6-dimethyl-2-methylenebicyclo[3.1.1]heptane.


go_id: GO:0033075
term: isoquinoline alkaloid biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin.


go_id: GO:0033076
term: isoquinoline alkaloid metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving isoquinoline alkaloids, alkaloid compounds that contain bicyclic N-containing aromatic rings and are derived from a 3,4-dihydroxytyramine (dopamine) precursor that undergoes a Schiff base addition with aldehydes of different origin.


go_id: GO:0033077
term: T cell differentiation in thymus
ontology: BP
definition:
The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway dependent upon transit through the thymus.


go_id: GO:0033078
term: extrathymic T cell differentiation
ontology: BP
definition:
The process in which a precursor cell type acquires the specialized features of a T cell via a differentiation pathway independent of the thymus.


go_id: GO:0033084
term: regulation of immature T cell proliferation in thymus
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of immature T cell proliferation in the thymus.


go_id: GO:0033085
term: negative regulation of T cell differentiation in thymus
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of T cell differentiation in the thymus.


go_id: GO:0033086
term: negative regulation of extrathymic T cell differentiation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of extrathymic T cell differentiation.


go_id: GO:0033087
term: negative regulation of immature T cell proliferation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation.


go_id: GO:0033088
term: negative regulation of immature T cell proliferation in thymus
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of immature T cell proliferation in the thymus.


go_id: GO:0033089
term: positive regulation of T cell differentiation in thymus
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of T cell differentiation in the thymus.


go_id: GO:0033090
term: positive regulation of extrathymic T cell differentiation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of extrathymic T cell differentiation.


go_id: GO:0033091
term: positive regulation of immature T cell proliferation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of immature T cell proliferation.


go_id: GO:0033092
term: positive regulation of immature T cell proliferation in thymus
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of immature T cell proliferation in the thymus.


go_id: GO:0033093
term: Weibel-Palade body
ontology: CC
definition:
A large, elongated, rod-shaped secretory granule characteristic of vascular endothelial cells that contain a number of structurally and functionally distinct proteins, of which the best characterized are von Willebrand factor (VWF) and P-selectin. Weibel-Palade bodies are formed from the trans-Golgi network in a process that depends on VWF, which is densely packed in a highly organized manner, and on coat proteins that remain associated with the granules. Upon cell stimulation, regulated exocytosis releases the contained proteins to the cell surface, where they act in the recruitment of platelets and leukocytes and in inflammatory and vasoactive responses.


go_id: GO:0033095
term: aleurone grain
ontology: CC
definition:
A membrane-bounded storage granule found in cells of the aleurone layer in plants; contains either a protein matrix, protein-carbohydrate bodies and/or globoids. Aleurone grains are formed by the vacuole, rough endoplasmic reticulum and dictyosomes.


go_id: GO:0033096
term: amyloplast envelope
ontology: CC
definition:
The double lipid bilayer enclosing the amyloplast and separating its contents from the rest of the cytoplasm; includes the intermembrane space.


go_id: GO:0033098
term: amyloplast inner membrane
ontology: CC
definition:
The inner, i.e. lumen-facing, lipid bilayer of the amyloplast envelope; also faces the amyloplast stroma.


go_id: GO:0033099
term: attachment organelle
ontology: CC
definition:
A membrane-bounded extension of the cell, originally characterized in Mycoplasma species, that contains an electron-dense core that is part of the cytoskeleton and is oriented lengthwise and ends distally in a bulbous knob (terminal button). Required for adherence to host cells and involved in gliding motility and cell division.


go_id: GO:0033100
term: NuA3 histone acetyltransferase complex
ontology: CC
definition:
A Gcn5-independent multisubunit complex that catalyzes the acetylation of histone H3. The budding yeast complex includes Sas3p, Taf30p, and Yng1p.


go_id: GO:0033103
term: protein secretion by the type VI secretion system
ontology: BP
definition:
The process in which proteins are transferred into the extracellular milieu or directly into host cells by the type VI secretion system. Proteins secreted by this system do not require an N-terminal signal sequence.


go_id: GO:0033104
term: type VI protein secretion system complex
ontology: CC
definition:
A complex of proteins that permits the transfer of proteins into the extracellular milieu or directly into host cells via the type VI secretion system. Proteins secreted by this complex do not require an N-terminal signal sequence.


go_id: GO:0033105
term: chlorosome envelope
ontology: CC
definition:
The structure, composed of a monolayer of glycolipids with embedded proteins, that encloses the pigments and other contents of the chlorosome.


go_id: GO:0033107
term: Cvt vesicle
ontology: CC
definition:
A cytosolic vesicle that is enclosed by a double membrane and is implicated in the cytoplasm to vacuole targeting pathway. These vesicles are found in the yeast S. cerevisiae, and contain vacuolar hydrolases, aminopeptidase I (Ape1p) and alpha-mannosidase (Ams1p).


go_id: GO:0033108
term: mitochondrial respiratory chain complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a mitochondrial respiratory chain complex.


go_id: GO:0033110
term: Cvt vesicle membrane
ontology: CC
definition:
Either of the two lipid bilayers surrounding a Cvt vesicle, a vesicle that functions in the cytoplasm-to-vacuole targeting (Cvt) pathway.


go_id: GO:0033111
term: attachment organelle membrane
ontology: CC
definition:
The lipid bilayer surrounding an attachment organelle.  This is a region of the cell membrane facing the environment - in mycoplasma, part of the mycolate outer membrane.


go_id: GO:0033112
term: cyanelle envelope
ontology: CC
definition:
The double lipid bilayer enclosing the cyanelle and separating its contents from the rest of the cytoplasm; includes the intermembrane space.


go_id: GO:0033116
term: endoplasmic reticulum-Golgi intermediate compartment membrane
ontology: CC
definition:
The lipid bilayer surrounding any of the compartments of the endoplasmic reticulum (ER)-Golgi intermediate compartment system.


go_id: GO:0033118
term: esterosome membrane
ontology: CC
definition:
The lipid bilayer surrounding an esterosome. This membrane has characteristics of rough endoplasmic reticulum (RER) membranes.


go_id: GO:0033121
term: regulation of purine nucleotide catabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.


go_id: GO:0033122
term: negative regulation of purine nucleotide catabolic process
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.


go_id: GO:0033123
term: positive regulation of purine nucleotide catabolic process
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of purine nucleotides.


go_id: GO:0033131
term: regulation of glucokinase activity
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.


go_id: GO:0033132
term: negative regulation of glucokinase activity
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.


go_id: GO:0033133
term: positive regulation of glucokinase activity
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of glucokinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a glucose molecule.


go_id: GO:0033137
term: negative regulation of peptidyl-serine phosphorylation
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of peptidyl-serine.


go_id: GO:0033138
term: positive regulation of peptidyl-serine phosphorylation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the phosphorylation of peptidyl-serine.


go_id: GO:0033139
term: regulation of peptidyl-serine phosphorylation of STAT protein
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


go_id: GO:0033140
term: negative regulation of peptidyl-serine phosphorylation of STAT protein
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


go_id: GO:0033141
term: positive regulation of peptidyl-serine phosphorylation of STAT protein
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the phosphorylation of a serine residue of a STAT (Signal Transducer and Activator of Transcription) protein.


go_id: GO:0033143
term: regulation of intracellular steroid hormone receptor signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.


go_id: GO:0033144
term: negative regulation of intracellular steroid hormone receptor signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.


go_id: GO:0033145
term: positive regulation of intracellular steroid hormone receptor signaling pathway
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the activity of any intracellular steroid hormone receptor signaling pathway.


go_id: GO:0033146
term: regulation of intracellular estrogen receptor signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.


go_id: GO:0033147
term: negative regulation of intracellular estrogen receptor signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.


go_id: GO:0033148
term: positive regulation of intracellular estrogen receptor signaling pathway
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the activity of an intracellular estrogen receptor signaling pathway.


go_id: GO:0033149
term: FFAT motif binding
ontology: MF
definition:
Binding to a FFAT motif, a short motif containing diphenylalanine in an acidic tract that targets proteins to the cytosolic surface of the ER and to the nuclear membrane by binding directly to members of the VAP (VAMP-associated protein) protein family.


go_id: GO:0033150
term: cytoskeletal calyx
ontology: CC
definition:
A large cytoskeletal structure located at the posterior end of the perinuclear theca of a mammalian sperm head. The nucleus is tightly associated with the calyx, which contains calicin and basic cylicin proteins.


go_id: GO:0033151
term: V(D)J recombination
ontology: BP
definition:
The process in which immune receptor V, D, and J, or V and J gene segments, depending on the specific receptor, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).


go_id: GO:0033152
term: immunoglobulin V(D)J recombination
ontology: BP
definition:
The process in which immunoglobulin gene segments are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS). For immunoglobulin heavy chains V, D, and J gene segments are joined, and for immunoglobulin light chains V and J gene segments are joined.


go_id: GO:0033153
term: T cell receptor V(D)J recombination
ontology: BP
definition:
The process in which T cell receptor V, D, and J, or V and J gene segments, depending on the specific locus, are recombined within a single locus utilizing the conserved heptamer and nonomer recombination signal sequences (RSS).


go_id: GO:0033154
term: ABC-type oligogalacturonide transporter activity
ontology: MF
definition:
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + oligogalacturonide(out) = ADP + phosphate + oligogalacturonide(in).


go_id: GO:0033156
term: oligogalacturonide transport
ontology: BP
definition:
The directed movement of oligogalacturonides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0033157
term: regulation of intracellular protein transport
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of proteins within cells.


go_id: GO:0033161
term: mitogen-activated protein kinase kinase kinase kinase binding
ontology: MF
definition:
Binding to a mitogen-activated protein kinase kinase kinase kinase, a protein that can phosphorylate a MAP kinase kinase kinase.


go_id: GO:0033164
term: glycolipid 1,6-alpha-mannosyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of an alpha-D-mannosyl residue from GDP-mannose into lipid-linked oligosaccharide, forming an alpha-(1->6)-D-mannosyl-D-mannose linkage.


go_id: GO:0033165
term: interphotoreceptor matrix
ontology: CC
definition:
A specialized extracellularc matrix that surrounds the photoreceptors of the retina and lies between them and the apical surface of the retinal pigment epithelium. The IPM has been implicated in several important activities required for photoreceptor function and maintenance.


go_id: GO:0033166
term: hyaline layer
ontology: CC
definition:
A multilayered extraembryonic matrix that functions as a substrate for cell adhesion through early development. It is thought to protect and lubricate the embryo, stabilize the blastomeres during morphogenesis, and regulate nutrient intake. The major constituent of the hyaline layer is the protein hyalin. This matrix has been found in echinoderms.


go_id: GO:0033167
term: ARC complex
ontology: CC
definition:
A ribonucleoprotein complex that contains members of the Argonaute family of proteins, additional protein subunits, and duplex siRNA; required for heterochromatin assembly and siRNA generation. Possibly involved in the conversion of ds siRNA to ss siRNA.


go_id: GO:0033169
term: histone H3-K9 demethylation
ontology: BP
definition:
The modification of histone H3 by the removal of a methyl group from lysine at position 9 of the histone.


go_id: GO:0033173
term: calcineurin-NFAT signaling cascade
ontology: BP
definition:
Any intracellular signal transduction in which the signal is passed on within the cell by activation of a member of the NFAT protein family as a consequence of NFAT dephosphorylation by Ca(2+)-activated calcineurin. The cascade begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin dephosphorylates multiple phosphoserine residues on NFAT, resulting in the translocation of NFAT to the nucleus. The cascade ends with regulation of transcription by NFAT. The calcineurin-NFAT cascade lies downstream of many cell surface receptors, including G protein-coupled receptors (GPCRs) and receptor tyrosine kinases (RTKs) that signal to mobilize calcium ions (Ca2+).


go_id: GO:0033174
term: chloroplast proton-transporting ATP synthase complex, catalytic core CF(1)
ontology: CC
definition:
The catalytic sector of the mitochondrial hydrogen-transporting ATP synthase; it comprises the catalytic core and central stalk, and is peripherally associated with the chloroplast thylakoid membrane when the entire ATP synthase is assembled. The chloroplast F0 domain contains three alpha, three beta, one gamma, one delta, and one epsilon subunits.


go_id: GO:0033175
term: chloroplast proton-transporting ATP synthase complex, coupling factor CF(o)
ontology: CC
definition:
All non-F1 subunits of the chloroplast hydrogen-transporting ATP synthase, including integral and peripheral chloroplast thylakoid membrane proteins.


go_id: GO:0033176
term: proton-transporting V-type ATPase complex
ontology: CC
definition:
A proton-transporting two-sector ATPase complex that couples ATP hydrolysis to the transport of protons across a concentration gradient. The resulting transmembrane electrochemical potential of H+ is used to drive a variety of (i) secondary active transport systems via H+-dependent symporters and antiporters and (ii) channel-mediated transport systems. The complex comprises a membrane sector (V0) that carries out proton transport and a cytoplasmic compartment sector (V1) that catalyzes ATP hydrolysis. V-type ATPases are found in the membranes of organelles such as vacuoles, endosomes, and lysosomes, and in the plasma membrane.


go_id: GO:0033177
term: proton-transporting two-sector ATPase complex, proton-transporting domain
ontology: CC
definition:
A protein complex that forms part of a proton-transporting two-sector ATPase complex and carries out proton transport across a membrane. The proton-transporting domain (F0, V0, or A0) includes integral and peripheral membrane proteins.


go_id: GO:0033178
term: proton-transporting two-sector ATPase complex, catalytic domain
ontology: CC
definition:
A protein complex that forms part of a proton-transporting two-sector ATPase complex and catalyzes ATP hydrolysis or synthesis. The catalytic domain (F1, V1, or A1) comprises a hexameric catalytic core and a central stalk, and is peripherally associated with the membrane when the two-sector ATPase is assembled.


go_id: GO:0033179
term: proton-transporting V-type ATPase, V0 domain
ontology: CC
definition:
A protein complex that forms part of a proton-transporting V-type ATPase and mediates proton transport across a membrane. The V0 complex consists of at least four different subunits (a,c,d and e); six or more c subunits form a proton-binding rotor ring.


go_id: GO:0033180
term: proton-transporting V-type ATPase, V1 domain
ontology: CC
definition:
A protein complex that forms part of a proton-transporting V-type ATPase and catalyzes ATP hydrolysis. The V1 complex consists of: (1) a globular headpiece with three alternating copies of subunits A and B that form a ring, (2) a central rotational stalk composed of single copies of subunits D and F, and (3) a peripheral stalk made of subunits C, E, G and H. Subunits A and B mediate the hydrolysis of ATP at three reaction sites associated with subunit A.


go_id: GO:0033182
term: regulation of histone ubiquitination
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the addition of a ubiquitin group to a histone protein.


go_id: GO:0033183
term: negative regulation of histone ubiquitination
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the addition of a ubiquitin group to a histone protein.


go_id: GO:0033184
term: positive regulation of histone ubiquitination
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the addition of a ubiquitin group to a histone protein.


go_id: GO:0033185
term: dolichol-phosphate-mannose synthase complex
ontology: CC
definition:
A protein complex that possesses dolichyl-phosphate beta-D-mannosyltransferase activity; contains a catalytic subunit, a regulatory subunit, and a third subunit that stabilizes the complex. In human and several other metazoa, the subunits are named DPM1, DPM2 and DPM3, respectively.


go_id: GO:0033186
term: CAF-1 complex
ontology: CC
definition:
A conserved heterotrimeric protein complex that promotes histone H3 and H4 deposition onto newly synthesized DNA during replication or DNA repair; specifically facilitates replication-dependent nucleosome assembly with the major histone H3 (H3.1). In many species the CAF-1 subunits are designated p150, p60, and p48.


go_id: GO:0033188
term: sphingomyelin synthase activity
ontology: MF
definition:
Catalysis of the reaction: 1,2-diacyl-sn-glycero-3-phosphocholine + ceramide = 1,2-diacyl-sn-glycerol + sphingomyelin.


go_id: GO:0033189
term: response to vitamin A
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin A stimulus.


go_id: GO:0033192
term: calmodulin-dependent protein phosphatase activity
ontology: MF
definition:
Catalysis of the reaction: protein serine/threonine phosphate + H2O = protein serine/threonine + phosphate, dependent on the presence of calcium-bound calmodulin.


go_id: GO:0033193
term: Lsd1/2 complex
ontology: CC
definition:
A nucleosome-binding protein complex that comprises two SWIRM domain histone demethylases and two PHD finger proteins. The complex is involved in transcriptional regulation via heterochromatic silencing and the regulation of chromatin boundary formation, and was first identified in fission yeast.


go_id: GO:0033194
term: response to hydroperoxide
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hydroperoxide stimulus. Hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH.


go_id: GO:0033195
term: response to alkyl hydroperoxide
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alkyl hydroperoxide stimulus. Alkyl hydroperoxides are monosubstitution products of hydrogen peroxide, HOOH, where the substituent is an alkyl group.


go_id: GO:0033197
term: response to vitamin E
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vitamin E stimulus.


go_id: GO:0033198
term: response to ATP
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an ATP (adenosine 5'-triphosphate) stimulus.


go_id: GO:0033200
term: inositol heptakisphosphate 5-kinase activity
ontology: MF
definition:
Catalysis of the reaction: ATP + 4-diphospho-1D-myo-inositol (1,2,3,5,6)pentakisphosphate = 4,5-bisdiphosphoinositol-1D-myoinositol (1,2,3,6)tetrakisphosphate, and ATP + 6-diphospho-1D-myo-inositol (1,2,3,4,5)pentakisphosphate = 5,6-bisdiphosphoinositol-1D-myoinositol (1,2,3,4)tetrakisphosphate.


go_id: GO:0033201
term: alpha-1,4-glucan synthase activity
ontology: MF
definition:
Catalysis of the reaction: RDP-glucose + [alpha-D-glucosyl-(1,4)]n = RDP + [alpha-D-glucosyl-(1,4)]n+1, where RDP is ADP or UDP.


go_id: GO:0033203
term: DNA helicase A complex
ontology: CC
definition:
A homohexameric protein complex that possesses DNA helicase activity; associates with DNA polymerase alpha-primase and translocates in the 5' to 3' direction.


go_id: GO:0033206
term: meiotic cytokinesis
ontology: BP
definition:
A cell cycle process that results in the division of the cytoplasm of a cell after meiosis, resulting in the separation of the original cell into two daughter cells.


go_id: GO:0033207
term: beta-1,4-N-acetylgalactosaminyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of an N-acetylgalactosaminyl residue from UDP-N-acetyl-galactosamine to an acceptor molecule, forming a beta-1,4 linkage.


go_id: GO:0033208
ontology: MF
term:
UDP-N-acetylgalactosamine:N-acetylneuraminyl-alpha-2,3-galactosyl-beta-R 1,4-N-acetylgalactosaminyltransferase activity

definition:
Catalysis of the reaction: UDP-N-acetylgalactosamine + N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide = UDP + N-acetylgalactosaminyl-N-acetylneuraminyl-alpha-2,3-galactosyl-beta-oligosaccharide.


go_id: GO:0033209
term: tumor necrosis factor-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by tumor necrosis factor binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0033210
term: leptin-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Leptin is a hormone manufactured primarily in the adipocytes of white adipose tissue, and the level of circulating leptin is directly proportional to the total amount of fat in the body.


