# go_term

go_id: GO:0035441
term: cell migration involved in vasculogenesis
ontology: BP
definition:
The orderly movement of a cell from one site to another that will contribute to the differentiation of an endothelial cell that will form de novo blood vessels and tubes.


go_id: GO:0035442
term: dipeptide transmembrane transport
ontology: BP
definition:
The directed movement of a dipeptide across a membrane by means of some agent such as a transporter or pore. A dipeptide is a combination of two amino acids linked together by a peptide (-CO-NH-) bond.


go_id: GO:0035443
term: tripeptide transmembrane transport
ontology: BP
definition:
The directed movement of a tripeptide across a membrane by means of some agent such as a transporter or pore. A tripeptide is a compound containing three amino acids linked together by peptide bonds.


go_id: GO:0035444
term: nickel cation transmembrane transport
ontology: BP
definition:
The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore.


go_id: GO:0035445
term: borate transmembrane transport
ontology: BP
definition:
The process in which borate is transported across a membrane. Borate is the anion (BO3)3-; boron is a group 13 element, with properties which are borderline between metals and non-metals.


go_id: GO:0035446
term: cysteine-glucosaminylinositol ligase activity
ontology: MF
definition:
Catalysis of the reaction: 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol + L-cysteine + ATP = 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + AMP + diphosphate + 2 H+. 1-(2-amino-2-deoxy-alpha-D-glucopyranoside)-1D-myo-inositol is also known as glucosaminyl-inositol or GlcN-Ins, and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as desacetylmycothiol or Cys-GlcN-Ins.


go_id: GO:0035447
term: mycothiol synthase activity
ontology: MF
definition:
Catalysis of the reaction: 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside + acetyl-CoA = mycothiol + coenzyme A + H+. Mycothiol is also known as AcCys-GlcN-Ins and 1-D-myo-inosityl-2-L-cysteinylamido-2-deoxy-alpha-D-glucopyranoside as Cys-GlcN-Ins or desacetylmycothiol.


go_id: GO:0035448
term: extrinsic component of thylakoid membrane
ontology: CC
definition:
The component of a thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0035449
term: extrinsic component of plastid thylakoid membrane
ontology: CC
definition:
The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0035450
term: extrinsic component of lumenal side of plastid thylakoid membrane
ontology: CC
definition:
The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its lumenal surface, but not integrated into the hydrophobic region.


go_id: GO:0035451
term: extrinsic component of stromal side of plastid thylakoid membrane
ontology: CC
definition:
The component of a plastid thylakoid membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region.


go_id: GO:0035452
term: extrinsic component of plastid membrane
ontology: CC
definition:
The component of a plastid membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0035453
term: extrinsic component of plastid inner membrane
ontology: CC
definition:
The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0035454
term: extrinsic component of stromal side of plastid inner membrane
ontology: CC
definition:
The component of a plastid inner membrane consisting of gene products and protein complexes that are loosely bound to its stromal surface, but not integrated into the hydrophobic region.


go_id: GO:0035455
term: response to interferon-alpha
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.


go_id: GO:0035456
term: response to interferon-beta
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.


go_id: GO:0035457
term: cellular response to interferon-alpha
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-alpha stimulus. Interferon-alpha is a type I interferon.


go_id: GO:0035458
term: cellular response to interferon-beta
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interferon-beta stimulus. Interferon-beta is a type I interferon.


go_id: GO:0035459
term: vesicle cargo loading
ontology: BP
definition:
The formation of a macromolecular complex between the coat proteins and proteins and/or lipoproteins that are going to be transported by a vesicle.


go_id: GO:0035461
term: vitamin transmembrane transport
ontology: BP
definition:
The process in which a vitamin is transported across a membrane. A vitamin is one of a number of unrelated organic substances that occur in many foods in small amounts and that are necessary in trace amounts for the normal metabolic functioning of the body.


go_id: GO:0035463
ontology: BP
term:
transforming growth factor beta receptor signaling pathway involved in determination of left/right asymmetry

definition:
The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to determination of organismal asymmetry with respect to the left and right halves.


go_id: GO:0035464
ontology: BP
term:
regulation of transforming growth factor receptor beta signaling pathway involved in determination of left/right asymmetry

definition:
Any process that modulates the frequency, rate or extent of activity of any TGF-beta receptor signaling pathway that is involved in the determination of organismal asymmetry with regard to its left and right halves.


go_id: GO:0035469
term: determination of pancreatic left/right asymmetry
ontology: BP
definition:
Determination of the asymmetric location of the pancreas with respect to the left and right halves of the organism.


go_id: GO:0035470
term: positive regulation of vascular wound healing
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of blood vessel formation when new vessels emerge from the proliferation of pre-existing blood vessels and contribute to the series of events that restore integrity to damaged vasculature.


go_id: GO:0035471
term: luteinizing hormone signaling pathway involved in ovarian follicle development
ontology: BP
definition:
The series of molecular signals initiated by luteinizing hormone binding to a receptor, where the activated receptor signals via downstream effectors that contribute to progression of the ovarian follicle over time, from its formation to the mature structure.


go_id: GO:0035474
term: selective angioblast sprouting
ontology: BP
definition:
The segregation of angioblasts into discrete arterial and venous vessels from one common precursor vessel.


go_id: GO:0035475
term: angioblast cell migration involved in selective angioblast sprouting
ontology: BP
definition:
The directional migration of angioblast cells as part of selective angioblast sprouting, which results in angioblast segregation into arterial and venous populations.


go_id: GO:0035477
term: regulation of angioblast cell migration involved in selective angioblast sprouting
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of angioblast cell migration involved in selective angioblast sprouting.


go_id: GO:0035478
term: chylomicron binding
ontology: MF
definition:
Binding to a chylomicron, a large lipoprotein particle (diameter 75-1200 nm) composed of a central core of triglycerides and cholesterol surrounded by a protein-phospholipid coating. The proteins include one molecule of apolipoprotein B-48 and may include a variety of apolipoproteins, including APOAs, APOCs and APOE.


go_id: GO:0035479
term: angioblast cell migration from lateral mesoderm to midline
ontology: BP
definition:
The directed movement of angioblasts from the lateral mesoderm to the midline which occurs as part of the formation of the early midline vasculature.


go_id: GO:0035480
term: regulation of Notch signaling pathway involved in heart induction
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction.


go_id: GO:0035481
term: positive regulation of Notch signaling pathway involved in heart induction
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the series of molecular signals initiated by binding of an extracellular ligand to a Notch receptor on the surface of the target cell that contributes to heart induction.


go_id: GO:0035482
term: gastric motility
ontology: BP
definition:
The spontaneous peristaltic movements of the stomach that aid in digestion, moving food through the stomach and out through the pyloric sphincter into the duodenum.


go_id: GO:0035483
term: gastric emptying
ontology: BP
definition:
The process in which the liquid and liquid-suspended solid contents of the stomach exit through the pylorus into the duodenum.


go_id: GO:0035490
term: regulation of leukotriene production involved in inflammatory response
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response.


go_id: GO:0035491
term: positive regulation of leukotriene production involved in inflammatory response
ontology: BP
definition:
Any process that increases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response.


go_id: GO:0035492
term: negative regulation of leukotriene production involved in inflammatory response
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of the synthesis or release of any leukotriene following a stimulus as part of an inflammatory response.


go_id: GO:0035493
term: SNARE complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a SNARE complex, a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


go_id: GO:0035494
term: SNARE complex disassembly
ontology: BP
definition:
The disaggregation of the SNARE protein complex into its constituent components. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


go_id: GO:0035495
term: regulation of SNARE complex disassembly
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


go_id: GO:0035496
term: lipopolysaccharide-1,5-galactosyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: UDP-galactose + lipopolysaccharide = UDP + 1,5 alpha-D-galactosyl-lipopolysaccharide.


go_id: GO:0035497
term: cAMP response element binding
ontology: MF
definition:
Binding to a cyclic AMP response element (CRE), a short palindrome-containing sequence found in the promoters of genes whose expression is regulated in response to cyclic AMP.


go_id: GO:0035499
term: carnosine biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of the dipeptide beta-alanyl-L-histidine (carnosine).


go_id: GO:0035500
term: MH2 domain binding
ontology: MF
definition:
Binding to a MH2 (MAD homology 2) protein domain. The MH2 domain is found at the carboxy-terminus of MAD related proteins such as Smads. The MH2 domain mediates interaction with a wide variety of proteins and provides specificity and selectivity to Smad function and also is critical for mediating interactions in Smad oligomers.


go_id: GO:0035501
term: MH1 domain binding
ontology: MF
definition:
Binding to a MH1 (MAD homology 1) protein domain. The MH1 domain is found at the amino terminus of MAD related proteins such as Smads and can mediate DNA binding in some proteins. Smads also use the MH1 domain to interact with some transcription factors.


go_id: GO:0035502
term: metanephric part of ureteric bud development
ontology: BP
definition:
The development of the portion of the ureteric bud tube that contributes to the morphogenesis of the metanephros.


go_id: GO:0035503
term: ureter part of ureteric bud development
ontology: BP
definition:
The development of the portion of the ureteric bud that contributes to the morphogenesis of the ureter. The ureter ureteric bud is the initial structure that forms the ureter.


go_id: GO:0035505
term: positive regulation of myosin light chain kinase activity
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of myosin light chain kinase activity.


go_id: GO:0035506
term: negative regulation of myosin light chain kinase activity
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of myosin light chain kinase activity.


go_id: GO:0035507
term: regulation of myosin-light-chain-phosphatase activity
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of myosin-light-chain-phosphatase activity.


go_id: GO:0035508
term: positive regulation of myosin-light-chain-phosphatase activity
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of myosin-light-chain-phosphatase activity.


go_id: GO:0035509
term: negative regulation of myosin-light-chain-phosphatase activity
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of myosin-light-chain-phosphatase activity.


go_id: GO:0035511
term: oxidative DNA demethylation
ontology: BP
definition:
Removal of the methyl group from one or more nucleotides within a DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.


go_id: GO:0035513
term: oxidative RNA demethylation
ontology: BP
definition:
The removal of the methyl group from one or more nucleotides within an RNA molecule involving oxidation (i.e. electron loss) of one or more atoms.


go_id: GO:0035515
term: oxidative RNA demethylase activity
ontology: MF
definition:
Catalysis of the removal of a methyl group from one or more nucleosides within a RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.


go_id: GO:0035516
term: oxidative DNA demethylase activity
ontology: MF
definition:
Catalysis of the reaction: a methylated nucleobase within DNA + 2-oxoglutarate + O(2) =  a nucleobase within DNA + formaldehyde + succinate + CO(2).


go_id: GO:0035517
term: PR-DUB complex
ontology: CC
definition:
A multimeric protein complex that removes monoubiquitin from histone H2A. In Drosophila and mammals, the core of the complex is composed of Calypso/BAP1 and Asx/ASXL1, respectively.


go_id: GO:0035519
term: protein K29-linked ubiquitination
ontology: BP
definition:
A protein ubiquitination process in which a polymer of ubiquitin, formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is added to a protein. K29-linked ubiquitination targets the substrate protein for degradation.


go_id: GO:0035523
term: protein K29-linked deubiquitination
ontology: BP
definition:
A protein deubiquitination process in which a K29-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 29 of the ubiquitin monomers, is removed from a protein.


go_id: GO:0035524
term: proline transmembrane transport
ontology: BP
definition:
The directed movement of proline, pyrrolidine-2-carboxylic acid, across a membrane by means of some agent such as a transporter or pore.


go_id: GO:0035526
term: retrograde transport, plasma membrane to Golgi
ontology: BP
definition:
The directed movement of substances from the plasma membrane back to the trans-Golgi network, mediated by vesicles.


go_id: GO:0035530
term: chemokine (C-C motif) ligand 6 production
ontology: BP
definition:
The appearance of chemokine (C-C motif) ligand 6 (CCL6) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0035531
term: regulation of chemokine (C-C motif) ligand 6 production
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6).


go_id: GO:0035532
term: negative regulation of chemokine (C-C motif) ligand 6 production
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6).


go_id: GO:0035533
term: positive regulation of chemokine (C-C motif) ligand 6 production
ontology: BP
definition:
Any process that activates or increases the frequency, rate, or extent of production of chemokine (C-C motif) ligand 6 (CCL6).


go_id: GO:0035538
term: carbohydrate response element binding
ontology: MF
definition:
Binding to a carbohydrate response element (ChoRE) found in the promoters of genes whose expression is regulated in response to carbohydrates, such as the triglyceride synthesis genes.


go_id: GO:0035539
term: 8-oxo-7,8-dihydrodeoxyguanosine triphosphate pyrophosphatase activity
ontology: MF
definition:
Catalysis of the reaction: 8-oxo-7,8-dihydrodeoxyguanosine-triphosphate (8-oxo-dGTP) + H2O = 8-oxo-7,8-dihydrodeoxyguanosine phosphate (8-oxo-dGMP) + diphosphate. 8-oxo-dGTP is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for DNA synthesis causing transversion mutations. 8-oxo-dGTPase hydrolyses 8-oxo-dGTP to its monophosphate form to prevent the misincorporation of 8-oxo-dGTP into cellular DNA.


go_id: GO:0035540
term: positive regulation of SNARE complex disassembly
ontology: BP
definition:
Any process that increases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


go_id: GO:0035541
term: negative regulation of SNARE complex disassembly
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of disassembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


go_id: GO:0035542
term: regulation of SNARE complex assembly
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


go_id: GO:0035543
term: positive regulation of SNARE complex assembly
ontology: BP
definition:
Any process that increases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


go_id: GO:0035544
term: negative regulation of SNARE complex assembly
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of assembly of the SNARE complex. The SNARE complex is a protein complex involved in membrane fusion; a stable ternary complex consisting of a four-helix bundle, usually formed from one R-SNARE and three Q-SNAREs with an ionic layer sandwiched between hydrophobic layers.


go_id: GO:0035550
term: urease complex
ontology: CC
definition:
A multiprotein nickel-containing complex that possesses urease activity (catalysis of the hydrolysis of urea to ammonia and carbon dioxide).


go_id: GO:0035551
term: protein initiator methionine removal involved in protein maturation
ontology: BP
definition:
Removal of the initiating methionine or formylmethionine residue from a protein that contributes to protein maturation, the attainment of the full functional capacity of a protein.


go_id: GO:0035552
term: oxidative single-stranded DNA demethylation
ontology: BP
definition:
Removal of the methyl group from one or more nucleotides within a single-stranded DNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.


go_id: GO:0035553
term: oxidative single-stranded RNA demethylation
ontology: BP
definition:
Removal of the methyl group from one or more nucleotides within a single-stranded RNA molecule involving the oxidation (i.e. electron loss) of one or more atoms.


go_id: GO:0035554
term: termination of Roundabout signal transduction
ontology: BP
definition:
The signaling process in which signaling from the receptor ROBO is brought to an end, rather than being reversibly modulated.


go_id: GO:0035556
term: intracellular signal transduction
ontology: BP
definition:
The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.


go_id: GO:0035560
term: pheophorbidase activity
ontology: MF
definition:
Catalysis of the reaction: pheophorbide a + H2O = pyropheophorbide a + methanol + CO2. The reaction occurs in two steps; pheophoridase catalyzes the conversion of pheophorbide a to a precursor of pyropheophorbide a, C-13(2)-carboxylpyropheophorbide a, by demethylation, and then the precursor is decarboxylated non-enzymatically to yield pyropheophorbide a.


go_id: GO:0035561
term: regulation of chromatin binding
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.


go_id: GO:0035562
term: negative regulation of chromatin binding
ontology: BP
definition:
Any process that stops or reduces the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.


go_id: GO:0035563
term: positive regulation of chromatin binding
ontology: BP
definition:
Any process that increases the frequency, rate or extent of chromatin binding. Chromatin binding is the selective interaction with chromatin, the network of fibers of DNA, protein, and sometimes RNA, that make up the chromosomes of the eukaryotic nucleus during interphase.


go_id: GO:0035567
term: non-canonical Wnt signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via effectors other than beta-catenin.


go_id: GO:0035573
term: N-terminal peptidyl-serine trimethylation
ontology: BP
definition:
The trimethylation of the N-terminal serine of proteins to form the derivative N,N,N-trimethylserine.


go_id: GO:0035574
term: histone H4-K20 demethylation
ontology: BP
definition:
The modification of histone H4 by the removal of a methyl group from lysine at position 20 of the histone.


go_id: GO:0035575
term: histone H4-methyl-lysine-20 demethylase activity
ontology: MF
definition:
Catalysis of the removal of the methyl group from a modified lysine residue at position 20 of the histone H4 protein. This is a dioxygenase reaction that is dependent on Fe(II) and 2-oxoglutarate.


go_id: GO:0035576
term: retinoic acid receptor signaling pathway involved in pronephric field specification
ontology: BP
definition:
The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that results in regions of the embryo being delineated into the area in which the pronephric kidney will develop.


go_id: GO:0035577
term: azurophil granule membrane
ontology: CC
definition:
The lipid bilayer surrounding an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.


go_id: GO:0035578
term: azurophil granule lumen
ontology: CC
definition:
The volume enclosed by the membrane of an azurophil granule, a primary lysosomal granule found in neutrophil granulocytes that contains a wide range of hydrolytic enzymes and is released into the extracellular fluid.


go_id: GO:0035579
term: specific granule membrane
ontology: CC
definition:
The lipid bilayer surrounding a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.


go_id: GO:0035580
term: specific granule lumen
ontology: CC
definition:
The volume enclosed by the membrane of a specific granule, a granule with a membranous, tubular internal structure, found primarily in mature neutrophil cells. Most are released into the extracellular fluid. Specific granules contain lactoferrin, lysozyme, vitamin B12 binding protein and elastase.


go_id: GO:0035581
term: sequestering of extracellular ligand from receptor
ontology: BP
definition:
The process of binding or confining an extracellular signaling ligand, such that the ligand is unable to bind to its cell surface receptor.


go_id: GO:0035582
term: sequestering of BMP in extracellular matrix
ontology: BP
definition:
Confining a bone morphogenetic protein (BMP) to the extracellular matrix (ECM), such that it is separated from other components of the signaling pathway, including its cell surface receptor. Bone morphogenetic proteins (BMPs) are secreted as homodimers, non-covalently associated with N-terminal pro-peptides, and are targeted to the extracellular matrix through interaction with matrix proteins.


go_id: GO:0035583
term: sequestering of TGFbeta in extracellular matrix
ontology: BP
definition:
Confining TGFbeta to the extracellular matrix (ECM) such that it is separated from other components of the signaling pathway, including its cell surface receptor. TGFbeta is secreted as part of a latent complex that is targeted to the extracellular matrix through latent-TGFbeta-binding protein (LTBP)-mediated association with matrix proteins.


go_id: GO:0035584
term: calcium-mediated signaling using intracellular calcium source
ontology: BP
definition:
The series of molecular signals in which a cell uses calcium ions released from an intracellular store to convert a signal into a response.


go_id: GO:0035585
term: calcium-mediated signaling using extracellular calcium source
ontology: BP
definition:
The series of molecular signals in which a cell uses calcium ions imported from an extracellular source to convert a signal into a response.


go_id: GO:0035588
term: G protein-coupled purinergic receptor signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway initiated by an extracellular purine or purine derivative binding to its receptor, and ending with the regulation of a downstream cellular process.


go_id: GO:0035589
term: G protein-coupled purinergic nucleotide receptor signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process.


go_id: GO:0035590
term: purinergic nucleotide receptor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by an extracellular purine nucleotide binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0035591
term: signaling adaptor activity
ontology: MF
definition:
The binding activity of a molecule that brings together two or more molecules in a signaling pathway, permitting those molecules to function in a coordinated way. Adaptor molecules themselves do not have catalytic activity.


go_id: GO:0035593
ontology: BP
term:
positive regulation of Wnt signaling pathway by establishment of Wnt protein localization to extracellular region

definition:
Any process that activates or increases the frequency, rate or extent of the Wnt signaling pathway by the directed movement of a Wnt protein within the extracellular region.


go_id: GO:0035594
term: ganglioside binding
ontology: MF
definition:
Binding to a ganglioside, a ceramide oligosaccharide carrying in addition to other sugar residues, one or more sialic acid residues.


go_id: GO:0035595
term: N-acetylglucosaminylinositol deacetylase activity
ontology: MF
definition:
Catalysis of the reaction: 1D-myo-inositol 2-acetamido-2-deoxy-alpha-D-glucopyranoside + H2O = 1D-myo-inositol 2-amino-2-deoxy-alpha-D-glucopyranoside + acetate. This reaction is the hydrolysis of an acetyl group from N-acetylglucosaminylinositol.


go_id: GO:0035597
term: N6-isopentenyladenosine methylthiotransferase activity
ontology: MF
definition:
Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-isopentenyladenosine (i6A) in tRNA, to form 2-methylthio-N6-isopentenyladenosine (ms2i6A).


go_id: GO:0035598
term: N6-threonylcarbomyladenosine methylthiotransferase activity
ontology: MF
definition:
Catalysis of the methylthiolation (-SCH3 addition) at the C2 of the adenosine ring of N6-threonylcarbomyladenosine (t6A) in tRNA, to form 2-methylthio-N6-threonylcarbamoyladenosine (ms2t6A).


go_id: GO:0035599
term: aspartic acid methylthiotransferase activity
ontology: MF
definition:
Catalysis of the methylthiolation (-SCH3 addition) of the beta-carbon of peptidyl-aspartic acid to form peptidyl-L-beta-methylthioaspartic acid.


go_id: GO:0035601
term: protein deacylation
ontology: BP
definition:
The removal of an acyl group, any group or radical of the form RCO- where R is an organic group, from a protein amino acid.


go_id: GO:0035602
ontology: BP
term:
fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow cell

definition:
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which stops, prevents, or reduces the frequency, rate or extent of the occurrence or rate of cell death by apoptotic process in the bone marrow.


go_id: GO:0035603
term: fibroblast growth factor receptor signaling pathway involved in hemopoiesis
ontology: BP
definition:
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which contributes to hemopoiesis.


go_id: GO:0035604
ontology: BP
term:
fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow

definition:
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands, which activates or increases the frequency, rate or extent of cell proliferation in the bone marrow.


go_id: GO:0035605
term: peptidyl-cysteine S-nitrosylase activity
ontology: MF
definition:
Catalysis of the transfer of a nitric oxide (NO) group to a sulphur atom within a cysteine residue of a protein.


go_id: GO:0035607
term: fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development
ontology: BP
definition:
The series of molecular signals generated as a consequence of a fibroblast growth factor-type receptor binding to one of its physiological ligands, which contributes to the progression of the orbitofrontal cortex over time from its initial formation until its mature state.


go_id: GO:0035608
term: protein deglutamylation
ontology: BP
definition:
The removal of a glutamate residue from a protein. Glutamate residues in proteins can be gene-encoded, or added as side chains during the protein modification process of polyglutamylation.


go_id: GO:0035610
term: protein side chain deglutamylation
ontology: BP
definition:
The removal of a glutamate residue from the side chain of a protein. Glutamate side chains are added to glutamic acid residues within the primary protein sequence during polyglutamylation.


go_id: GO:0035611
term: protein branching point deglutamylation
ontology: BP
definition:
The removal of a branching point glutamate residue. A branching point glutamate connects a glutamate side chain to a gene-encoded glutamate residue.


go_id: GO:0035612
term: AP-2 adaptor complex binding
ontology: MF
definition:
Binding to an AP-2 adaptor complex. The AP-2 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).


go_id: GO:0035613
term: RNA stem-loop binding
ontology: MF
definition:
Binding to a stem-loop in an RNA molecule. An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.


go_id: GO:0035614
term: snRNA stem-loop binding
ontology: MF
definition:
Binding to a stem-loop in a small nuclear RNA (snRNA). An RNA stem-loop is a secondary RNA structure consisting of a double-stranded RNA (dsRNA) stem and a terminal loop.


go_id: GO:0035615
term: clathrin adaptor activity
ontology: MF
definition:
Bringing together a cargo protein with clathrin, responsible for the formation of endocytic vesicles.


go_id: GO:0035616
term: histone H2B conserved C-terminal lysine deubiquitination
ontology: BP
definition:
A histone deubiquitination process in which a ubiquitin monomer is removed from a conserved lysine residue in the C-terminus of histone H2B. The conserved lysine residue is K119 in fission yeast, K123 in budding yeast, or K120 in mammals.


go_id: GO:0035618
term: root hair
ontology: CC
definition:
A long, thin projection from a root epidermal cell that contains F-actin and tubulin, and a cell wall.


go_id: GO:0035621
term: ER to Golgi ceramide transport
ontology: BP
definition:
The directed movement of a ceramide from the endoplasmic reticulum (ER) to the Golgi. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid.


go_id: GO:0035622
term: intrahepatic bile duct development
ontology: BP
definition:
The progression of the intrahepatic bile ducts over time, from their formation to the mature structure. Intrahepatic bile ducts (bile ducts within the liver) collect bile from bile canaliculi in the liver, and connect to the extrahepatic bile ducts (bile ducts outside the liver).


go_id: GO:0035623
term: renal glucose absorption
ontology: BP
definition:
A renal system process in which glucose is taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.


go_id: GO:0035624
term: receptor transactivation
ontology: BP
definition:
The process in which a receptor is activated by another receptor. Receptor transactivation can occur through different mechanisms and includes cross-talk between signaling pathways where one receptor activates a receptor for a different ligand, and also activation of subunits within a receptor oligomer.


go_id: GO:0035626
term: juvenile hormone mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a juvenile hormone binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0035627
term: ceramide transport
ontology: BP
definition:
The directed movement of ceramides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Ceramides are a class of lipid composed of sphingosine linked to a fatty acid.


go_id: GO:0035628
term: cystic duct development
ontology: BP
definition:
The progression of the cystic duct over time, from its formation to the mature structure. The cystic duct runs from the gall bladder to the common bile duct.


go_id: GO:0035629
term: N-terminal protein amino acid N-linked glycosylation
ontology: BP
definition:
Addition of a carbohydrate or carbohydrate derivative unit via a nitrogen (N) atom of the N-terminal amino acid of a protein.


go_id: GO:0035630
term: bone mineralization involved in bone maturation
ontology: BP
definition:
The deposition of hydroxyapatite, involved in the progression of the skeleton from its formation to its mature state.


go_id: GO:0035631
term: CD40 receptor complex
ontology: CC
definition:
A protein complex that contains at least CD40 (a cell surface receptor of the tumour necrosis factor receptor (TNFR) superfamily), and other signaling molecules.


go_id: GO:0035632
term: mitochondrial prohibitin complex
ontology: CC
definition:
A complex composed of two proteins, prohibitin 1 and prohibitin 2 (PHB1/PHB-1 and PHB2/PHB-2) that is highly conserved amongst eukaryotes and associated with the inner mitochondrial membrane. The mitochondrial prohibitin complex is a macromolecular supercomplex composed of repeating heterodimeric subunits of PHB1 and PHB2. The mitochondrial prohibitin complex plays a role in a number of biological processes, including mitochondrial biogenesis and function, development, replicative senescence, and cell death.


go_id: GO:0035633
term: maintenance of blood-brain barrier
ontology: BP
definition:
Maintaining the structure and function of the blood-brain barrier, thus ensuring specific regulated transport of substances (e.g. macromolecules, small molecules, ions) into the brain, and out of the brain into the blood circulation.


go_id: GO:0035634
term: response to stilbenoid
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of exposure to a stilbenoid. Stilbenoids are secondary products of heartwood formation in trees that can act as phytoalexins. Stilbenoids are hydroxylated derivatives of stilbene. They belong to the family of phenylpropanoids and share most of their biosynthesis pathway with chalcones.


go_id: GO:0035635
term: entry of bacterium into host cell
ontology: BP
definition:
The process in which a bacterium enters a host cell. The host is defined as the larger of the organisms involved in a symbiotic interaction.


go_id: GO:0035639
term: purine ribonucleoside triphosphate binding
ontology: MF
definition:
Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.


go_id: GO:0035642
term: histone methyltransferase activity (H3-R17 specific)
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + (histone H3)-arginine (position 17) = S-adenosyl-L-homocysteine + (histone H3)-N-methyl-arginine (position 17). This reaction is the addition of a methyl group to arginine at position 17 of histone H3.


go_id: GO:0035643
term: L-DOPA receptor activity
ontology: MF
definition:
Combining with L-DOPA to initiate a change in cell activity. L-DOPA is the modified amino acid (2S)-2-amino-3-(3,4-dihydroxyphenyl) propanoic acid, and is the precursor to dopamine, norepinephrine (noradrenaline) and epinephrine.


go_id: GO:0035645
term: enteric smooth muscle cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell of the intestine.


go_id: GO:0035646
term: endosome to melanosome transport
ontology: BP
definition:
The directed movement of substances from endosomes to the melanosome, a specialised lysosome-related organelle.


go_id: GO:0035647
term: 3-oxo-delta(4,5)-steroid 5-beta-reductase activity
ontology: MF
definition:
Catalysis of the reaction: a 3-oxo-delta-4,5-steroid + NADPH + H(+) = a 5-beta-3-oxo-steroid + NADP(+).


go_id: GO:0035649
term: Nrd1 complex
ontology: CC
definition:
A complex that functions in transcription termination of RNA polymerase II transcribed non-coding RNAs. This complex interacts with the carboxy-terminal domain (CTD) of PolII and the terminator sequences in the nascent RNA transcript. In yeast this complex consists of Nrd1p, Nab3p, and Sen1p.


go_id: GO:0035650
term: AP-1 adaptor complex binding
ontology: MF
definition:
Binding to an AP-1 adaptor complex. The AP-1 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta1, gamma, mu1 and sigma1 subunits and links clathrin to the membrane surface of a vesicle. In at least humans, the AP-1 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (gamma1 and gamma2, mu1A and mu1B, and sigma1A, sigma1B and sigma1C).


go_id: GO:0035651
term: AP-3 adaptor complex binding
ontology: MF
definition:
Binding to an AP-3 adaptor complex. The AP-3 adaptor complex is a heterotetrameric AP-type membrane coat adaptor complex that consists of beta3, delta, mu3 and sigma3 subunits and is found associated with endosomal membranes. In at least humans, the AP-3 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different genes (beta3A and beta3B, mu3A and mu3B, and sigma3A and sigma3B).


go_id: GO:0035652
term: clathrin-coated vesicle cargo loading
ontology: BP
definition:
Formation of a macromolecular complex between the cytoplasmic coat proteins on clathrin-coated vesicles and proteins and/or lipoproteins that are going to be transported by a vesicle.


go_id: GO:0035653
term: clathrin-coated vesicle cargo loading, AP-1-mediated
ontology: BP
definition:
Formation of a macromolecular complex between proteins of the AP-1 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. The AP-1 adaptor protein complex is a component of the cytoplasmic coat found on clathrin-coated vesicles, and binds to sorting signals of cargo to facilitate their trafficking.


go_id: GO:0035654
term: clathrin-coated vesicle cargo loading, AP-3-mediated
ontology: BP
definition:
Formation of a macromolecular complex between proteins of the AP-3 adaptor complex and proteins and/or lipoproteins that are going to be transported by a clathrin-coated vesicle. In some cases, the AP-3 complex is a heterotetrameric AP-type membrane coat adaptor complex that, in some organisms, links clathrin to the membrane surface of a vesicle.


go_id: GO:0035655
term: interleukin-18-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-18 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0035657
term: eRF1 methyltransferase complex
ontology: CC
definition:
A protein complex required for the methylation of a glutamine (Gln) residue in the protein release factor eRF1. In S. cerevisiae, this complex consists of at least Trm112p and Mtq2p.


go_id: GO:0035658
term: Mon1-Ccz1 complex
ontology: CC
definition:
A protein complex that functions as a guanine nucleotide exchange factor (GEF) and converts Rab-GDP to Rab-GTP. In S. cerevisiae, this complex consists of at least Mon1 and Ccz1, and serves as a GEF for the Rab Ypt7p.


go_id: GO:0035659
term: Wnt signaling pathway involved in wound healing, spreading of epidermal cells
ontology: BP
definition:
The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of a target cell in the epidermis that contributes to the migration of an epidermal cell along or through a wound gap to reestablish a continuous epidermis.


go_id: GO:0035660
term: MyD88-dependent toll-like receptor 4 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a ligand binding to a toll-like 4 receptor, where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 4 receptors bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.


go_id: GO:0035661
term: MyD88-dependent toll-like receptor 2 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a ligand binding to a toll-like 2 receptor where the MyD88 adaptor molecule mediates transduction of the signal. Toll-like 2 receptors are pattern recognition receptors that bind microbial pattern motifs to initiate an innate immune response.


go_id: GO:0035662
term: Toll-like receptor 4 binding
ontology: MF
definition:
Binding to a Toll-like 4 protein, a pattern recognition receptor that binds bacterial lipopolysaccharide (LPS) to initiate an innate immune response.


go_id: GO:0035663
term: Toll-like receptor 2 binding
ontology: MF
definition:
Binding to a Toll-like 2 protein, a pattern recognition receptor that binds microbial pattern motifs to initiate an innate immune response.


go_id: GO:0035664
term: TIRAP-dependent toll-like receptor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.


go_id: GO:0035665
term: TIRAP-dependent toll-like receptor 4 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TIRAP/MAL adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.


go_id: GO:0035666
term: TRIF-dependent toll-like receptor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRIF adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.


go_id: GO:0035667
term: TRIF-dependent toll-like receptor 4 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a ligand binding to a toll-like 4 receptor where the TRIF adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.


go_id: GO:0035668
term: TRAM-dependent toll-like receptor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a ligand binding to a toll-like receptor where the TRAM adaptor mediates transduction of the signal. Toll-like receptors directly bind pattern motifs from a variety of microbial sources to initiate an innate immune response.


go_id: GO:0035669
term: TRAM-dependent toll-like receptor 4 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a ligand binding to a toll-like receptor 4 where the TRAM adaptor mediates transduction of the signal. Toll-like 4 receptors are pattern recognition receptors that bind bacterial lipopolysaccharide (LPS) to initiate an innate immune response.


go_id: GO:0035670
term: plant-type ovary development
ontology: BP
definition:
The process whose specific outcome is the progression of an ovary that produces an ovule over time, from its formation to the mature structure. The ovary is the enlarged basal portion of a carpel and matures into a fruit. An ovule is the multicellular structure that gives rise to and contains the female reproductive cells, and develops into a seed.


go_id: GO:0035672
term: oligopeptide transmembrane transport
ontology: BP
definition:
The process in which an oligopeptide is transported across a membrane. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


go_id: GO:0035673
term: oligopeptide transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of oligopeptides from one side of a membrane to the other. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


go_id: GO:0035675
term: neuromast hair cell development
ontology: BP
definition:
The process whose specific outcome is the progression of a neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate.


go_id: GO:0035676
term: anterior lateral line neuromast hair cell development
ontology: BP
definition:
The process whose specific outcome is the progression of an anterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate.


go_id: GO:0035677
term: posterior lateral line neuromast hair cell development
ontology: BP
definition:
The process whose specific outcome is the progression of a posterior lateral line neuromast hair cell over time, from its formation to the mature structure. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface. Cell development does not include the steps involved in committing a cell to a specific fate.


go_id: GO:0035678
term: neuromast hair cell morphogenesis
ontology: BP
definition:
The change in form (cell shape and size) that occurs when a neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface.


go_id: GO:0035679
term: anterior lateral line neuromast hair cell morphogenesis
ontology: BP
definition:
The change in form (cell shape and size) that occurs when an anterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface.


go_id: GO:0035680
term: posterior lateral line neuromast hair cell morphogenesis
ontology: BP
definition:
The change in form (cell shape and size) that occurs when a posterior lateral line neuromast hair cell progresses from its initial formation to its mature state. A neuromast hair cell is a hair cell that acts as a sensory receptor of the neuromast; it is morphologically polarized as a result of the relative position of the single kinocilium and the clusters of stereocilia on its apical surface.


go_id: GO:0035683
term: memory T cell extravasation
ontology: BP
definition:
The migration of a memory T cell from the blood vessels into the surrounding tissue. A memory T cell is a distinctly differentiated long-lived T cell that has the phenotype CD45RO-positive and CD127-positive.


go_id: GO:0035684
term: helper T cell extravasation
ontology: BP
definition:
The migration of a helper T cell from the blood vessels into the surrounding tissue. A helper T-cell is an effector T cell that provides help in the form of secreted cytokines to other immune cells.


go_id: GO:0035685
term: helper T cell diapedesis
ontology: BP
definition:
The passage of a helper T cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation.


go_id: GO:0035686
term: sperm fibrous sheath
ontology: CC
definition:
A cytoskeletal structure surrounding the axoneme and outer dense fibers of the sperm flagellum. Consists of two longitudinal columns connected by closely arrayed semicircular ribs that assemble from distal to proximal throughout spermiogenesis. The fibrous sheath probably influences the degree of flexibility, plane of flagellar motion, and the shape of the flagellar beat.


go_id: GO:0035687
term: T-helper 1 cell extravasation
ontology: BP
definition:
The migration of a T-helper 1 cell from the blood vessels into the surrounding tissue. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.


go_id: GO:0035688
term: T-helper 1 cell diapedesis
ontology: BP
definition:
The passage of a T-helper 1 cell between the tight junctions of endothelial cells lining blood vessels, typically the fourth and final step of cellular extravasation. A T-helper 1 cell is a CD4-positive, alpha-beta T cell that has the phenotype T-bet-positive and produces interferon-gamma.


go_id: GO:0035689
term: chemokine (C-C motif) ligand 5 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by chemokine CCL5 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0035691
term: macrophage migration inhibitory factor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by macrophage migration inhibitory factor binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0035692
term: macrophage migration inhibitory factor receptor complex
ontology: CC
definition:
A protein complex that binds macrophage migration inhibitory factor. Comprises CD74 and CD44 cell surface proteins.


go_id: GO:0035693
term: NOS2-CD74 complex
ontology: CC
definition:
A protein complex comprising nitric oxide synthase 2 and CD74. This stable complex formation is thought to prevent CD74 degradation by caspases.


go_id: GO:0035694
term: mitochondrial protein catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a mitochondrial protein. This process is necessary to maintain the healthy state of mitochondria and is thought to occur via the induction of an intramitochondrial lysosome-like organelle that acts to eliminate the damaged oxidised mitochondrial proteins without destroying the mitochondrial structure.


go_id: GO:0035695
term: mitophagy by induced vacuole formation
ontology: BP
definition:
The process in which cells degrade mitochondria by inducing a vacuole-like structure which directly engulfs and degrades the unhealthy mitochondria by accumulating lysosomes.


go_id: GO:0035697
term: CD8-positive, alpha-beta T cell extravasation
ontology: BP
definition:
The migration of a CD8-positive, alpha-beta T cell from the blood vessels into the surrounding tissue.


go_id: GO:0035698
term: CD8-positive, alpha-beta cytotoxic T cell extravasation
ontology: BP
definition:
The migration of a CD8-positive, alpha-beta cytotoxic T cell from the blood vessels into the surrounding tissue.


go_id: GO:0035700
term: astrocyte chemotaxis
ontology: BP
definition:
The directed movement of an astrocyte guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).


go_id: GO:0035701
term: hematopoietic stem cell migration
ontology: BP
definition:
The orderly movement of a hematopoietic stem cell from one site to another. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.


go_id: GO:0035702
term: monocyte homeostasis
ontology: BP
definition:
The process of regulating the proliferation and elimination of monocytes such that the total number of monocytes within a whole or part of an organism is stable over time in the absence of an outside stimulus.


go_id: GO:0035708
term: interleukin-4-dependent isotype switching to IgE isotypes
ontology: BP
definition:
The switching of activated B cells from IgM biosynthesis to IgE biosynthesis, accomplished through a recombination process involving an intrachromosomal deletion between switch regions that reside 5' of the IgM and IgE constant region gene segments in the immunoglobulin heavy chain locus, that is dependent on the activity of interleukin 4 (IL-4).


go_id: GO:0035709
term: memory T cell activation
ontology: BP
definition:
The change in morphology and behavior of a memory T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


go_id: GO:0035710
term: CD4-positive, alpha-beta T cell activation
ontology: BP
definition:
The change in morphology and behavior of a CD4-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


go_id: GO:0035711
term: T-helper 1 cell activation
ontology: BP
definition:
The change in morphology and behavior of a T-helper 1 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


go_id: GO:0035712
term: T-helper 2 cell activation
ontology: BP
definition:
The change in morphology and behavior of a T helper 2 cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


go_id: GO:0035713
term: response to nitrogen dioxide
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus.


go_id: GO:0035714
term: cellular response to nitrogen dioxide
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nitrogen dioxide (NO2) stimulus.


go_id: GO:0035720
term: intraciliary anterograde transport
ontology: BP
definition:
The directed movement of large protein complexes along microtubules from the cell body toward the tip of a cilium (also called flagellum), mediated by motor proteins.


go_id: GO:0035721
term: intraciliary retrograde transport
ontology: BP
definition:
The directed movement of large protein complexes along microtubules from the tip of a cilium (also called flagellum) toward the cell body, mediated by motor proteins.


go_id: GO:0035722
term: interleukin-12-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-12 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0035723
term: interleukin-15-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-15 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0035724
term: CD24 biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of CD24, a CD marker and cell adhesion molecule that occurs on many B-lineage cells and mature granulocytes, and is involved in B cell activation and differentiation as well as T cell co-stimulation.


go_id: GO:0035725
term: sodium ion transmembrane transport
ontology: BP
definition:
A process in which a sodium ion is transported from one side of a membrane to the other by means of some agent such as a transporter or pore.


go_id: GO:0035726
term: common myeloid progenitor cell proliferation
ontology: BP
definition:
The multiplication or reproduction of common myeloid progenitor cells, resulting in the expansion of a cell population. A common myeloid progenitor cell is a progenitor cell committed to the myeloid lineage.


go_id: GO:0035727
term: lysophosphatidic acid binding
ontology: MF
definition:
Binding to lysophosphatidic acid (LPA), a phospholipid derivative that acts as a potent mitogen due to its activation of high-affinity G protein-coupled receptors.


go_id: GO:0035728
term: response to hepatocyte growth factor
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.


go_id: GO:0035729
term: cellular response to hepatocyte growth factor stimulus
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a hepatocyte growth factor stimulus.


go_id: GO:0035730
term: S-nitrosoglutathione binding
ontology: MF
definition:
Binding to S-nitrosoglutathione, a nitrosothiol considered to be a natural nitric oxide (NO) donor involved in S-nitrosylation, and in the storage and transport of nitric oxide in biological systems.


go_id: GO:0035731
term: dinitrosyl-iron complex binding
ontology: MF
definition:
Binding to a dinitrosyl-iron complex. Nitric oxide (NO) is stored as dinitrosyl-iron complexes, which form spontaneously from Glutathione (GSH), S-nitrosoglutathione, and trace amounts of ferrous ions, or by reaction of iron-sulfur centers with NO.


go_id: GO:0035732
term: nitric oxide storage
ontology: BP
definition:
The accumulation and maintenance in cells or tissues of nitric oxide (NO). Nitric oxide is stored in the form of dinitrosyl-iron complexes, which are stabilized, and possibly sequestered, by binding to glutathione S-transferase proteins.


go_id: GO:0035733
term: hepatic stellate cell activation
ontology: BP
definition:
A change in the morphology or behavior of a hepatic stellate cell resulting from exposure to a cytokine, chemokine, hormone, cellular ligand or soluble factor.


go_id: GO:0035735
term: intraciliary transport involved in cilium assembly
ontology: BP
definition:
The bidirectional movement of large protein complexes along microtubules within a cilium that contributes to cilium assembly.


go_id: GO:0035736
term: cell proliferation involved in compound eye morphogenesis
ontology: BP
definition:
The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to compound eye morphogenesis.


go_id: GO:0035738
term: envenomation resulting in modulation of process in another organism
ontology: BP
definition:
The process which begins with venom being forced into an organism by the bite or sting of another organism, and ends with the manifestation of some change or damage to the bitten organism.


go_id: GO:0035746
term: granzyme A production
ontology: BP
definition:
The appearance of granzyme A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0035747
term: natural killer cell chemotaxis
ontology: BP
definition:
The directed movement of a natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).


go_id: GO:0035750
term: protein localization to myelin sheath abaxonal region
ontology: BP
definition:
Any process in which a protein is transported to, and/or maintained in, the abaxonal region of the myelin sheath. The abaxonal region is the region of the myelin sheath furthest from the axon.


go_id: GO:0035751
term: regulation of lysosomal lumen pH
ontology: BP
definition:
Any process that modulates the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.


go_id: GO:0035752
term: lysosomal lumen pH elevation
ontology: BP
definition:
Any process that increases the pH of the lysosomal lumen, measured by the concentration of the hydrogen ion.


go_id: GO:0035753
term: maintenance of DNA trinucleotide repeats
ontology: BP
definition:
Any process involved in sustaining the fidelity and copy number of DNA trinucleotide repeats. DNA trinucleotide repeats are naturally occurring runs of three base-pairs.


go_id: GO:0035754
term: B cell chemotaxis
ontology: BP
definition:
The directed movement of a B cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).


go_id: GO:0035755
term: cardiolipin hydrolase activity
ontology: MF
definition:
Catalysis of the hydrolysis of cardiolipin (1,3-bis(3-phosphatidyl)glycerol), releasing phosphatidic acid (PA).


go_id: GO:0035756
term: transepithelial migration of symbiont in host
ontology: BP
definition:
The directional movement of an organism from one side of an epithelium to the other within its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


go_id: GO:0035759
term: mesangial cell-matrix adhesion
ontology: BP
definition:
The binding of a mesangial cell to the extracellular matrix via adhesion molecules. A mesangial cell is a cell that encapsulates the capillaries and venules in the kidney.


go_id: GO:0035760
term: cytoplasmic polyadenylation-dependent rRNA catabolic process
ontology: BP
definition:
The chemical reactions and pathways occurring in the cytoplasm and resulting in the breakdown of a ribosomal RNA (rRNA) molecule, initiated by the enzymatic addition of a sequence of adenylyl residues (polyadenylation) at the 3' end the target rRNA truncated degradation intermediate.


go_id: GO:0035761
term: dorsal motor nucleus of vagus nerve maturation
ontology: BP
definition:
A developmental process, independent of morphogenetic (shape) change, that is required for the dorsal motor nucleus of the vagus nerve to attain its fully functional state.


go_id: GO:0035762
term: dorsal motor nucleus of vagus nerve morphogenesis
ontology: BP
definition:
The process in which the dorsal motor nucleus of the vagus nerve is generated and organized. Morphogenesis pertains to the creation of form.


go_id: GO:0035763
term: dorsal motor nucleus of vagus nerve structural organization
ontology: BP
definition:
The process that contributes to the act of creating the structural organization of the dorsal motor nucleus of the vagus nerve. This process pertains to the physical shaping of a rudimentary structure.


go_id: GO:0035764
term: dorsal motor nucleus of vagus nerve formation
ontology: BP
definition:
The process that gives rise to the dorsal motor nucleus of the vagus nerve. This process pertains to the initial formation of a structure from unspecified parts.


go_id: GO:0035765
term: motor neuron precursor migration involved in dorsal motor nucleus of vagus nerve formation
ontology: BP
definition:
The orderly movement of a motor neuron precursor cell that contributes to formation of the dorsal motor nucleus of the vagus nerve.


go_id: GO:0035766
term: cell chemotaxis to fibroblast growth factor
ontology: BP
definition:
The directed movement of a motile cell in response to the presence of fibroblast growth factor (FGF).


go_id: GO:0035767
term: endothelial cell chemotaxis
ontology: BP
definition:
The directed movement of an endothelial cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis).


go_id: GO:0035768
term: endothelial cell chemotaxis to fibroblast growth factor
ontology: BP
definition:
The directed movement of an endothelial cell in response to the presence of fibroblast growth factor (FGF).


go_id: GO:0035770
term: ribonucleoprotein granule
ontology: CC
definition:
A non-membranous macromolecular complex containing proteins and translationally silenced mRNAs. RNA granules contain proteins that control the localization, stability, and translation of their RNA cargo. Different types of RNA granules (RGs) exist, depending on the cell type and cellular conditions.


go_id: GO:0035771
term: interleukin-4-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-4 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0035772
term: interleukin-13-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-13 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0035773
term: insulin secretion involved in cellular response to glucose stimulus
ontology: BP
definition:
The regulated release of proinsulin from secretory granules (B granules) in the B cells of the pancreas; accompanied by cleavage of proinsulin to form mature insulin, in response to a glucose stimulus.


go_id: GO:0035774
term: positive regulation of insulin secretion involved in cellular response to glucose stimulus
ontology: BP
definition:
Any process that increases the frequency, rate or extent of the regulated release of insulin that contributes to the response of a cell to glucose.


go_id: GO:0035775
term: pronephric glomerulus morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the pronephric glomerulus are generated and organized. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.


go_id: GO:0035776
term: pronephric proximal tubule development
ontology: BP
definition:
The progression of the pronephric proximal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.


go_id: GO:0035777
term: pronephric distal tubule development
ontology: BP
definition:
The process whose specific outcome is the progression of the pronephric distal tubule over time, from its formation to the mature structure. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.


go_id: GO:0035778
term: pronephric nephron tubule epithelial cell differentiation
ontology: BP
definition:
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephric nephron tubule as it progresses from its formation to the mature state.


go_id: GO:0035779
term: angioblast cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires the specialized structural and/or functional features of an angioblast cell. Angioblasts are one of the two products formed from hemangioblast cells (the other being pluripotent hemopoietic stem cells).


go_id: GO:0035780
term: CD80 biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of CD80, a CD marker that occurs on antigen presenting cells such as activated B cells and monocytes that provides a co-stimulatory signal necessary for T cell activation and survival.


go_id: GO:0035781
term: CD86 biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of CD86, a CD marker that occurs on antigen presenting cells that provides co-stimulatory signals necessary for T cell activation and survival.


go_id: GO:0035782
term: mature natural killer cell chemotaxis
ontology: BP
definition:
The directed movement of a mature natural killer cell guided by a specific chemical concentration gradient. Movement may be towards a higher concentration (positive chemotaxis) or towards a lower concentration (negative chemotaxis). A mature natural killer cell is a natural killer cell that is developmentally mature and expresses a variety of inhibitory and activating receptors that recognize MHC class and other stress related molecules.


go_id: GO:0035783
term: CD4-positive, alpha-beta T cell costimulation
ontology: BP
definition:
The process of providing, via surface-bound receptor-ligand pairs, a second, antigen-independent, signal in addition to that provided by the T cell receptor to augment CD4-positive, alpha-beta T cell activation.


go_id: GO:0035784
term: nickel cation homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of nickel cations within an organism or cell.


go_id: GO:0035785
term: cellular nickel ion homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of nickel ions at the level of a cell.


go_id: GO:0035787
term: cell migration involved in kidney development
ontology: BP
definition:
The orderly movement of a cell from one site to another that will contribute to the progression of the kidney over time, from its formation to the mature organ.


go_id: GO:0035788
term: cell migration involved in metanephros development
ontology: BP
definition:
The orderly movement of a cell from one site to another that will contribute to the progression of the metanephric kidney over time, from its formation to the mature organ.


go_id: GO:0035789
term: metanephric mesenchymal cell migration
ontology: BP
definition:
The orderly movement of undifferentiated metanephric mesenchymal cells (precursors to metanephric mesangial cells) from the mesenchyme into the cleft of the developing glomerulus, during development of the metanephros.


go_id: GO:0035790
term: platelet-derived growth factor receptor-alpha signaling pathway
ontology: BP
definition:
The series of molecular signals initiated a ligand binding to an alpha-type platelet-derived growth factor receptor (PDGFalpha) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0035791
term: platelet-derived growth factor receptor-beta signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of a ligand to a beta-type platelet-derived growth factor receptor (PDGFbeta) on the surface of a signal-receiving cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0035792
term: host cell postsynaptic membrane
ontology: CC
definition:
A postsynaptic membrane that is part of a host cell. A postsynaptic membrane is a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft). Neurotransmitters transmit the signal across the synaptic cleft to the postsynaptic membrane.


go_id: GO:0035793
ontology: BP
term:
positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway

definition:
Any process that increases the frequency, rate or extent of metanephric mesenchymal cell migration resulting from the platelet-derived growth factor receptor-beta signaling pathway.


go_id: GO:0035794
term: positive regulation of mitochondrial membrane permeability
ontology: BP
definition:
Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.


go_id: GO:0035795
term: negative regulation of mitochondrial membrane permeability
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the mitochondrial membrane.


go_id: GO:0035796
term: ATP-binding cassette (ABC) transporter complex, transmembrane substrate-binding subunit-containing
ontology: CC
definition:
A complex for the transport of metabolites into the cell, consisting of 4 subunits: a transmembrane substrate-binding protein (known as the S component), and an energy-coupling module that comprises two ATP-binding proteins (known as the A and A' components) and a transmembrane protein (known as the T component). Transport of the substrate across the membrane is driven by the hydrolysis of ATP.


go_id: GO:0035797
term: tellurite methyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to tellurite [TeO3(2-)]. Methylated derivatives of tellurite include Te(CH3)2 (dimethyltelluride) and Te2(CH3)2 (dimethylditelluride).


go_id: GO:0035799
term: ureter maturation
ontology: BP
definition:
A developmental process, independent of morphogenetic (shape) change, that is required for the ureter to attain its fully functional state. The ureter is a muscular tube that transports urine from the kidney to the urinary bladder or from the Malpighian tubule to the hindgut.


go_id: GO:0035800
term: deubiquitinase activator activity
ontology: MF
definition:
Binds to and increases the activity of deubiquitinase, an enzyme that catalyzes the hydrolysis of various forms of polymeric ubiquitin sequences.


go_id: GO:0035801
term: adrenal cortex development
ontology: BP
definition:
The process whose specific outcome is the progression of the adrenal cortex over time, from its formation to the mature structure. The adrenal cortex is located at the periphery of the adrenal gland and controls glucose and electrolyte metabolism, response to stress and sexual development through the production of different classes of steroid hormones (glucocorticoids, mineralocorticoids and androgens).


go_id: GO:0035802
term: adrenal cortex formation
ontology: BP
definition:
The process that gives rise to the adrenal cortex. This process pertains to the initial formation of a structure from unspecified parts. The adrenogonadal primordium from which the adrenal cortex is formed derives from a condensation of coelomic epithelial cells (the urogenital ridge; the same structure from which gonads and kidney also originate).


go_id: GO:0035803
term: egg coat formation
ontology: BP
definition:
Construction of an egg coat, a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.


go_id: GO:0035804
term: structural constituent of egg coat
ontology: MF
definition:
The action of a molecule that contributes to the structural integrity of an egg coat. An egg coat is a specialized extracellular matrix that surrounds the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.


go_id: GO:0035805
term: egg coat
ontology: CC
definition:
A specialized extracellular matrix that surrounds the plasma membrane of the ovum of animals. The egg coat provides structural support and can play an essential role in oogenesis, fertilization and early development.


go_id: GO:0035806
term: modulation of blood coagulation in another organism
ontology: BP
definition:
Any process in which an organism modulates the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot.


go_id: GO:0035807
term: positive regulation of blood coagulation in another organism
ontology: BP
definition:
Any process in which an organism activates, maintains or increases the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot.


go_id: GO:0035808
term: meiotic recombination initiation complex
ontology: CC
definition:
A protein complex that initiates the formation of double-strand breaks (DSBs) required for meiotic recombination. Consists of a protein that catalyses formation of the double-strand breaks (Spo11 in S. cerevisiae and Rec12 in S. pombe), and a number of accessory proteins.


go_id: GO:0035812
term: renal sodium excretion
ontology: BP
definition:
The elimination of sodium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine.


go_id: GO:0035816
term: renal water absorption involved in negative regulation of urine volume
ontology: BP
definition:
Any process where water is taken up from the collecting ducts and proximal and distal loops of the nephron, which acts to decrease the amount of urine that is excreted from the body per unit time.


go_id: GO:0035817
term: renal sodium ion absorption involved in negative regulation of renal sodium excretion
ontology: BP
definition:
Any process where sodium ions are taken up from the collecting ducts and proximal and distal loops of the nephron, which contributes to decreasing the amount of sodium that is excreted in urine per unit time.


go_id: GO:0035818
term: positive regulation of urine volume by pressure natriuresis
ontology: BP
definition:
An increase in the amount of urine excreted over a unit of time, as a result of pressure natriuresis.


go_id: GO:0035819
term: positive regulation of renal sodium excretion by pressure natriuresis
ontology: BP
definition:
An increase in the amount of sodium excreted in urine over a unit of time, as a result of pressure natriuresis.


go_id: GO:0035820
term: negative regulation of renal sodium excretion by angiotensin
ontology: BP
definition:
The process in which angiotensin decreases the amount of sodium that is excreted in urine over a unit of time.


go_id: GO:0035821
term: modulation of process of another organism
ontology: BP
definition:
The process in which an organism effects a change in the structure or processes of another organism.


go_id: GO:0035822
term: gene conversion
ontology: BP
definition:
A DNA recombination process that results in the unidirectional transfer of genetic material from a donor sequence to a highly homologous acceptor. The resulting acceptor sequence is identical to that of the donor.


go_id: GO:0035823
term: short tract gene conversion
ontology: BP
definition:
A gene conversion process in which a segment of about 50-200 base pairs is transferred from the donor to the acceptor.


go_id: GO:0035824
term: long tract gene conversion
ontology: BP
definition:
A gene conversion process in which a segment of more than 1000 base pairs is transferred from the donor to the acceptor.


go_id: GO:0035825
term: homologous recombination
ontology: BP
definition:
A DNA recombination process that results in the exchange of an equal amount of genetic material between highly homologous DNA molecules.


go_id: GO:0035831
term: palmatine biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of palmatine, a berberine alkaloid found in many plants.


go_id: GO:0035833
term: berbamunine biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of berbamunine, an isoquinoline alkaloid.


go_id: GO:0035834
term: indole alkaloid metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving an indole alkaloid, an alkaloid containing an indole skeleton.


go_id: GO:0035835
term: indole alkaloid biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of an indole alkaloid, an alkaloid containing an indole skeleton.


go_id: GO:0035838
term: growing cell tip
ontology: CC
definition:
The region at either end of the longest axis of a cylindrical or elongated cell, where polarized growth occurs.


go_id: GO:0035839
term: non-growing cell tip
ontology: CC
definition:
A cell tip at which no growth takes place. For example, in fission yeast the cell end newly formed by cell division does not grow immediately upon its formation, and lacks actin cytoskeletal structures.


go_id: GO:0035840
term: old growing cell tip
ontology: CC
definition:
A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs. For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures.


go_id: GO:0035841
term: new growing cell tip
ontology: CC
definition:
A cell tip that was newly formed at the last cell division, and that has started to grow after the cell has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). New end take-off is when monopolar cells initiate bipolar growth.


go_id: GO:0035842
term: old cell tip after activation of bipolar cell growth
ontology: CC
definition:
A cell tip which has existed for at least one complete cell cycle, and at which polarized growth occurs, which is part of a cell that has activated bipolar cell growth (i.e. in which new end take-off, NETO, has taken place). For example, in fission yeast the cell end that existed prior to cell division grows immediately after division, and contains a distinctive complement of proteins including actin cytoskeletal structures.


go_id: GO:0035843
term: endonuclear canal
ontology: CC
definition:
A membrane-bound structure present in the nucleus of a spermatozoon. There is variation in the number of endonuclear canals between sperm of different organisms, and some species lack these structures altogether. The endonuclear canal may provide a supporting role for the sperm nucleus, and originates during spermiogenesis from an invagination of the nuclear envelope.


go_id: GO:0035844
term: cloaca development
ontology: BP
definition:
The process whose specific outcome is the progression of the cloaca over time, from it's formation to the mature structure. The cloaca is the common chamber into which intestinal, genital and urinary canals open in vertebrates.


go_id: GO:0035845
term: photoreceptor cell outer segment organization
ontology: BP
definition:
A process that is carried out at the cellular level and results in the assembly, arrangement of constituent parts, or disassembly of the outer segment of a photoreceptor cell, a sensory cell that reacts to the presence of light. The outer segment of the photoreceptor cell contains the light-absorbing materials.


go_id: GO:0035846
term: oviduct epithelium development
ontology: BP
definition:
The progression of the oviduct epithelium over time from its initial formation to the mature structure. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism. The oviduct epithelium is the specialized epithelium that lines the oviduct.


go_id: GO:0035847
term: uterine epithelium development
ontology: BP
definition:
The progression of an epithelium of the uterus over time from its initial formation to the mature structure. An epithelium is a tissue that covers the internal or external surfaces of an anatomical structure.


go_id: GO:0035848
term: oviduct morphogenesis
ontology: BP
definition:
The process in which anatomical structures of the oviduct are generated and organized. An oviduct is a tube through which an ova passes from the ovary to the uterus, or from the ovary to the outside of the organism.


go_id: GO:0035849
term: nephric duct elongation
ontology: BP
definition:
The process in which the nephric duct grows along its axis. A nephric duct is a tube that drains a primitive kidney.


go_id: GO:0035850
term: epithelial cell differentiation involved in kidney development
ontology: BP
definition:
The process in which relatively unspecialized cells acquire specialized structural and/or functional features of an epithelial cell that characterize the cells of the kidney as it progresses from its formation to the mature state.


go_id: GO:0035851
term: Krueppel-associated box domain binding
ontology: MF
definition:
Binding to a Krueppel-associated box (KRAB) domain of a protein. The approximately 75 amino acid KRAB domain is enriched in charged amino acids, and is found in the N-terminal regions of many zinc finger-containing transcription factors.


go_id: GO:0035852
term: horizontal cell localization
ontology: BP
definition:
Any process in which a horizontal cell is transported to, and/or maintained in, a specific location within the inner nuclear layer (INL) of the retina. A horizontal cell is a neuron that laterally connects other neurons in the inner nuclear layer (INL) of the retina. Targeting of retinal neurons to the appropriate lamina is vital to establish the architecture of the retina.


go_id: GO:0035853
term: chromosome passenger complex localization to spindle midzone
ontology: BP
definition:
A cellular protein complex localization that acts on a chromosome passenger complex; as a result, the complex is transported to, or maintained in, a specific location at the spindle midzone. A chromosome passenger complex is a protein complex that contains the BIR-domain-containing protein Survivin, Aurora B kinase, INCENP and Borealin, and coordinates various events based on its location to different structures during the course of mitosis. The spindle midzone is the area in the center of the spindle where the spindle microtubules from opposite poles overlap.


go_id: GO:0035854
term: eosinophil fate commitment
ontology: BP
definition:
The process in which the developmental fate of a cell becomes restricted such that it will develop into a eosinophil cell. A eosinophil is any of the immature or mature forms of a granular leukocyte with a nucleus that usually has two lobes connected by one or more slender threads of chromatin, and cytoplasm containing coarse, round granules that are uniform in size and which can be stained by the dye eosin.


go_id: GO:0035855
term: megakaryocyte development
ontology: BP
definition:
The process whose specific outcome is the progression of a megakaryocyte cell over time, from its formation to the mature structure. Megakaryocyte development does not include the steps involved in committing a cell to a megakaryocyte fate. A megakaryocyte is a giant cell 50 to 100 micron in diameter, with a greatly lobulated nucleus, found in the bone marrow.


go_id: GO:0035857
term: eosinophil fate specification
ontology: BP
definition:
The process involved in the specification of identity of an eosinophil cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment.


go_id: GO:0035858
term: eosinophil fate determination
ontology: BP
definition:
The cell fate determination process in which a cell becomes capable of differentiating autonomously into an eosinophil cell regardless of its environment; upon determination, the cell fate cannot be reversed.


go_id: GO:0035859
term: Seh1-associated complex
ontology: CC
definition:
A GTPase-activating protein (GAP) complex that regulates TORC1 signaling by interacting with the Rag GTPase. In S. cerevisiae the complex contains Seh1p, Sec13p, Npr2p, Npr3p, Iml1p, Mtc5p, Rtc1p, and Sea4p.


go_id: GO:0035860
term: glial cell-derived neurotrophic factor receptor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a ligand binding to a glial cell-derived neurotrophic factor receptor.


go_id: GO:0035861
term: site of double-strand break
ontology: CC
definition:
A region of a chromosome at which a DNA double-strand break has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.


go_id: GO:0035862
term: dITP metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving dITP (deoxyinosine triphosphate (2'-deoxyinosine 5'-triphosphate). dITP is a deoxyinosine phosphate compound having a triphosphate group at the 5'-position.


go_id: GO:0035863
term: dITP catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of dITP, a deoxyinosine phosphate compound having a triphosphate group at the 5'-position.


go_id: GO:0035864
term: response to potassium ion
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.


go_id: GO:0035865
term: cellular response to potassium ion
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a potassium ion stimulus.


go_id: GO:0035866
term: alphav-beta3 integrin-PKCalpha complex
ontology: CC
definition:
A protein complex that consists of an alphav-beta3 integrin complex bound to protein kinase C alpha.


go_id: GO:0035867
term: alphav-beta3 integrin-IGF-1-IGF1R complex
ontology: CC
definition:
A protein complex that consists of an alphav-beta3 integrin complex bound to insulin-like growth factor-1 (IGF-1) and type I insulin-like growth factor receptor (IGF1R). IGF1R is a heterotetramer that consists of two alpha-subunits and two beta-subunits.


go_id: GO:0035868
term: alphav-beta3 integrin-HMGB1 complex
ontology: CC
definition:
A protein complex that consists of an alphav-beta3 integrin complex bound to high mobility group box 1 protein.


go_id: GO:0035869
term: ciliary transition zone
ontology: CC
definition:
A region of the cilium between the basal body and proximal segment that is characterized by Y-shaped assemblages that connect axonemal microtubules to the ciliary membrane. The ciliary transition zone appears to function as a gate that controls ciliary membrane composition and separates the cytosol from the ciliary plasm.


go_id: GO:0035871
term: protein K11-linked deubiquitination
ontology: BP
definition:
A protein deubiquitination process in which a K11-linked ubiquitin chain, i.e. a polymer of ubiquitin formed by linkages between lysine residues at position 11 of the ubiquitin monomers, is removed from a protein.


go_id: GO:0035872
term: nucleotide-binding domain, leucine rich repeat containing receptor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a ligand binding to a nucleotide-binding domain, leucine rich repeat containing receptor (NLR), and ending with the regulation of a downstream cellular process. NLRs are cytoplasmic receptors defined by their tripartite domain architecture that contains: a variable C-terminus, a middle nucleotide-binding domain, and a LRR domain that is variable in the repeats composition and number.


go_id: GO:0035873
term: lactate transmembrane transport
ontology: BP
definition:
The process in which lactate is transported across a membrane. Lactate is 2-hydroxypropanoate, CH3-CHOH-COOH; L(+)-lactate is formed by anaerobic glycolysis in animal tissues, and DL-lactate is found in sour milk, molasses and certain fruit juices.


go_id: GO:0035874
term: cellular response to copper ion starvation
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of copper ions.


go_id: GO:0035875
term: maintenance of meiotic sister chromatid cohesion, centromeric
ontology: BP
definition:
The process in which the association between sister chromatids of a replicated chromosome along the length of the centromeric region is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle.


go_id: GO:0035876
term: maintenance of meiotic sister chromatid cohesion, arms
ontology: BP
definition:
The process in which the association between sister chromatids of a replicated chromosome along the length of the chromosome arms, is maintained as chromosomes condense, attach to the spindle in a bipolar orientation, and congress to the metaphase plate during a meiotic cell cycle.


go_id: GO:0035877
term: death effector domain binding
ontology: MF
definition:
Binding to a DED domain (death effector domain) of a protein, a homotypic protein interaction module composed of a bundle of six alpha-helices that is related in structure to the death domain (DD).


go_id: GO:0035878
term: nail development
ontology: BP
definition:
The process whose specific outcome is the progression of a nail over time, from its formation to the mature structure. A nail is a horn-like envelope covering the outer end of a finger or toe, and consists of the nail plate, the nail matrix and the nail bed below it, and the grooves surrounding it.


go_id: GO:0035880
term: embryonic nail plate morphogenesis
ontology: BP
definition:
The process, occurring in the embryo, by which the anatomical structures of a nail plate are generated and organized. The nail plate is the hard and translucent portion of the nail, composed of keratin, and serves to protect the tips of digits.


go_id: GO:0035881
term: amacrine cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of an amacrine cell, an interneuron generated in the inner nuclear layer (INL) of the vertebrate retina. Amacrine cells integrate, modulate, and interpose a temporal domain in the visual message presented to the retinal ganglion cells, with which they synapse in the inner plexiform layer. Amacrine cells lack large axons.


go_id: GO:0035882
term: defecation rhythm
ontology: BP
definition:
The rhythmic process of defecation that consists of an intestinal oscillator which regulates calcium waves. These waves in turn control a stereotypical, three-part pattern of muscle contractions. In some organisms, defecation can recur with a regularity more frequent than every 24 hours. For example, in a well-fed Caenorhabditis elegans, the defecation motor program occurs approximately every 45 seconds, and is temperature- and touch-compensated.


go_id: GO:0035883
term: enteroendocrine cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized structural and/or functional features of an enteroendocrine cell. Enteroendocrine cells are hormonally active epithelial cells in the gut that constitute the diffuse neuroendocrine system.


go_id: GO:0035884
term: arabinan biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of arabinan, a polysaccharide composed of arabinose residues.


go_id: GO:0035885
term: exochitinase activity
ontology: MF
definition:
Catalysis of the hydrolysis of terminal 1,4-beta-linkages of N-acetyl-D-glucosamine (GlcNAc) polymers of chitin and chitodextrins. Typically, exochitinases progressively cleave off two subunits from the reducing or non-reducing ends of the chitin chain.


go_id: GO:0035886
term: vascular associated smooth muscle cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a vascular smooth muscle cell.


go_id: GO:0035887
term: aortic smooth muscle cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a smooth muscle cell surrounding the aorta.


go_id: GO:0035891
term: exit from host cell
ontology: BP
definition:
The directed movement of an organism out of a cell of the host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


go_id: GO:0035892
term: modulation of platelet aggregation in another organism
ontology: BP
definition:
Any process in which an organism modulates the frequency, rate or extent of platelet aggregation in another organism. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.


go_id: GO:0035893
term: negative regulation of platelet aggregation in another organism
ontology: BP
definition:
Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of platelet aggregation in a second organism.


go_id: GO:0035894
term: positive regulation of platelet aggregation in another organism
ontology: BP
definition:
Any process in which an organism activates, maintains or increases the frequency, rate or extent of platelet aggregation in another organism.


go_id: GO:0035895
term: modulation of mast cell degranulation in another organism
ontology: BP
definition:
Any process in which an organism modulates the frequency, rate or extent of blood mast cell degranulation in another organism. Mast cell degranulation is the regulated exocytosis of secretory granules containing preformed mediators such as histamine, serotonin, and neutral proteases by a mast cell.


go_id: GO:0035896
term: positive regulation of mast cell degranulation in another organism
ontology: BP
definition:
Any process in which an organism increases the frequency, rate or extent of blood mast cell degranulation in another organism.


go_id: GO:0035899
term: negative regulation of blood coagulation in another organism
ontology: BP
definition:
Any process in which an organism stops, prevents or reduces the frequency, rate or extent of blood coagulation in another organism. Blood coagulation is the sequential process in which the multiple coagulation factors of the blood interact, ultimately resulting in the formation of an insoluble fibrin clot.


go_id: GO:0035900
term: response to isolation stress
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species.


go_id: GO:0035901
term: cellular response to isolation stress
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lack of contact with other members of the same species.


go_id: GO:0035902
term: response to immobilization stress
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile.


go_id: GO:0035903
term: cellular response to immobilization stress
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of being rendered immobile.


go_id: GO:0035904
term: aorta development
ontology: BP
definition:
The progression of the aorta over time, from its initial formation to the mature structure. An aorta is an artery that carries blood from the heart to other parts of the body.


go_id: GO:0035905
term: ascending aorta development
ontology: BP
definition:
The progression of the ascending aorta over time, from its initial formation to the mature structure. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.


go_id: GO:0035906
term: descending aorta development
ontology: BP
definition:
The progression of the descending aorta over time, from its initial formation to the mature structure. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once.


go_id: GO:0035907
term: dorsal aorta development
ontology: BP
definition:
The progression of the dorsal aorta over time, from its initial formation to the mature structure. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.


go_id: GO:0035908
term: ventral aorta development
ontology: BP
definition:
The progression of the ventral aorta over time, from its initial formation to the mature structure. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once.


go_id: GO:0035909
term: aorta morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of an aorta are generated and organized. An aorta is an artery that carries blood from the heart to other parts of the body.


go_id: GO:0035910
term: ascending aorta morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the ascending aorta are generated and organized. The ascending aorta is the portion of the aorta in a two-pass circulatory system that lies between the heart and the arch of aorta. In a two-pass circulatory system blood passes twice through the heart to supply the body once.


go_id: GO:0035911
term: descending aorta morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the descending aorta are generated and organized. The descending aorta is the portion of the aorta in a two-pass circulatory system from the arch of aorta to the point where it divides into the common iliac arteries. In a two-pass circulatory system blood passes twice through the heart to supply the body once.


go_id: GO:0035912
term: dorsal aorta morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the dorsal aorta are generated and organized. The dorsal aorta is a blood vessel in a single-pass circulatory system that carries oxygenated blood from the gills to the rest of the body. In a single-pass circulatory system blood passes once through the heart to supply the body once.


go_id: GO:0035913
term: ventral aorta morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the ventral aorta are generated and organized. The ventral aorta is a blood vessel in a single-pass circulatory system that carries de-oxygenated blood from the heart to the gills. In a single-pass circulatory system blood passes once through the heart to supply the body once.


go_id: GO:0035914
term: skeletal muscle cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle cell, a somatic cell located in skeletal muscle.


go_id: GO:0035915
term: pore formation in membrane of another organism
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components by an organism to form a pore complex in a membrane of another organism.


go_id: GO:0035916
term: modulation of calcium channel activity in another organism
ontology: BP
definition:
Any process in which an organism effects a change in the frequency, rate or extent of the activity of a calcium channel in another organism.


go_id: GO:0035917
term: negative regulation of calcium channel activity in another organism
ontology: BP
definition:
Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a calcium channel in another organism.


go_id: GO:0035918
term: negative regulation of voltage-gated calcium channel activity in another organism
ontology: BP
definition:
Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a voltage-gated calcium channel in another organism. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0035919
term: negative regulation of low voltage-gated calcium channel activity in another organism
ontology: BP
definition:
Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a low voltage-gated calcium channel in another organism. A low voltage-gated channel is a channel whose open state is dependent on low voltage across the membrane in which it is embedded.


go_id: GO:0035920
term: negative regulation of high voltage-gated calcium channel activity in another organism
ontology: BP
definition:
Any process in which an organism stops, prevents or reduces the frequency, rate or extent of the activity of a high voltage-gated calcium channel in another organism. A high voltage-gated channel is a channel whose open state is dependent on high voltage across the membrane in which it is embedded.


go_id: GO:0035921
term: desmosome disassembly
ontology: BP
definition:
The controlled breakdown of a desmosome. A desmosome is a patch-like intercellular junction found in vertebrate tissues, consisting of parallel zones of two cell membranes, separated by an space of 25-35 nm, and having dense fibrillar plaques in the subjacent cytoplasm.


go_id: GO:0035922
term: foramen ovale closure
ontology: BP
definition:
The morphogenetic process in which the foramen ovale closes after birth, to prevent blood flow between the right and left atria. In the fetal heart, the foramen ovale allows blood to enter the left atrium from the right atrium. Closure of the foramen ovale after birth stops this blood flow.


go_id: GO:0035924
term: cellular response to vascular endothelial growth factor stimulus
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a vascular endothelial growth factor stimulus.


go_id: GO:0035925
term: mRNA 3'-UTR AU-rich region binding
ontology: MF
definition:
Binding to a region containing frequent adenine and uridine bases within the 3' untranslated region of a mRNA molecule or in pre-mRNA intron. The ARE-binding element consensus is UUAUUUAUU. ARE-binding proteins control the stability and/or translation of mRNAs.


go_id: GO:0035927
term: RNA import into mitochondrion
ontology: BP
definition:
The process in which a rRNA, ribosomal ribonucleic acid, is transported from the cytosol into the mitochondrial matrix.


go_id: GO:0035928
term: rRNA import into mitochondrion
ontology: BP
definition:
The process in which a rRNA, ribosomal ribonucleic acid, transported from the cytosol into the mitochondrial matrix.


go_id: GO:0035931
term: mineralocorticoid secretion
ontology: BP
definition:
The regulated release of any mineralocorticoid into the circulatory system. Mineralocorticoids are a class of steroid hormones that regulate water and electrolyte metabolism.


go_id: GO:0035932
term: aldosterone secretion
ontology: BP
definition:
The regulated release of aldosterone into the circulatory system. Aldosterone is a pregnane-based steroid hormone produced by the outer-section (zona glomerulosa) of the adrenal cortex in the adrenal gland, and acts on the distal tubules and collecting ducts of the kidney to cause the conservation of sodium, secretion of potassium, increased water retention, and increased blood pressure. The overall effect of aldosterone is to increase reabsorption of ions and water in the kidney.


go_id: GO:0035933
term: glucocorticoid secretion
ontology: BP
definition:
The regulated release of any glucocorticoid hormone into the circulatory system. Glucocorticoids are a class of steroid hormones that regulate a variety of physiological processes, in particular control of the concentration of glucose in blood.


go_id: GO:0035934
term: corticosterone secretion
ontology: BP
definition:
The regulated release of corticosterone into the circulatory system. Corticosterone is a 21-carbon steroid hormone of the corticosteroid type produced in the cortex of the adrenal glands.


go_id: GO:0035935
term: androgen secretion
ontology: BP
definition:
The regulated release of an androgen into the circulatory system. Androgens are steroid hormones that stimulate or control the development and maintenance of masculine characteristics in vertebrates.


go_id: GO:0035936
term: testosterone secretion
ontology: BP
definition:
The regulated release of testosterone into the circulatory system. Testosterone is an androgen having 17beta-hydroxy and 3-oxo groups, together with unsaturation at C-4-C-5.


go_id: GO:0035937
term: estrogen secretion
ontology: BP
definition:
The regulated release of estrogen into the circulatory system. Estrogen is a steroid hormone that stimulates or controls the development and maintenance of female sex characteristics in mammals.


go_id: GO:0035939
term: microsatellite binding
ontology: MF
definition:
Binding to a microsatellite, a repeat_region in DNA containing repeat units (2 to 4 base pairs) that is repeated multiple times in tandem.


go_id: GO:0035942
term: dehydroepiandrosterone secretion
ontology: BP
definition:
The regulated release of dehydroepiandrosterone (3beta-hydroxyandrost-5-en-17-one) into the circulatory system.


go_id: GO:0035944
term: perforin production
ontology: BP
definition:
The appearance of a perforin protein due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0035945
term: mitochondrial ncRNA surveillance
ontology: BP
definition:
The set of processes involved in identifying and degrading defective or aberrant non-coding RNA transcripts (ncRNAs) within the mitochondrion.


go_id: GO:0035946
term: mitochondrial mRNA surveillance
ontology: BP
definition:
The set of processes involved in identifying and degrading messenger RNA (mRNA) within the mitochondrion.


go_id: GO:0035962
term: response to interleukin-13
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus.


go_id: GO:0035963
term: cellular response to interleukin-13
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-13 stimulus.


go_id: GO:0035965
term: cardiolipin acyl-chain remodeling
ontology: BP
definition:
Remodeling the acyl chains of premature (de novo synthesized) cardiolipin (1,3-bis(3-phosphatidyl)glycerol), through sequential deacylation and re-acylation reactions, to generate mature cardiolipin containing high-levels of unsaturated fatty acids.


go_id: GO:0035966
term: response to topologically incorrect protein
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure.


go_id: GO:0035967
term: cellular response to topologically incorrect protein
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a protein that is not folded in its correct three-dimensional structure.


go_id: GO:0035974
term: meiotic spindle pole body
ontology: CC
definition:
The microtubule organizing center that forms as part of the meiotic cell cycle; functionally homologous to the animal cell centrosome.


go_id: GO:0035975
term: carbamoyl phosphate catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of carbamoyl phosphate, an intermediate in the urea cycle and other nitrogen compound metabolic pathways.


go_id: GO:0035976
term: transcription factor AP-1 complex
ontology: CC
definition:
A heterodimeric transcription factor complex composed of proteins from the c-Fos, c-Jun, activating transcription factor (ATF) or JDP families. The subunits contain a basic leucine zipper (bZIP) domain that is essential for dimerization and DNA binding. Jun-Fos heterodimers bind preferentially to a heptamer consensus sequence (TPA responsive element (TRE)), whereas Jun-ATF dimers bind the cyclic AMP responsive element (CRE) to regulate transcription of target genes.


go_id: GO:0035977
term: protein deglycosylation involved in glycoprotein catabolic process
ontology: BP
definition:
The removal of sugar residues from a glycosylated protein that contributes to the breakdown of a glycoprotein.


go_id: GO:0035979
term: histone kinase activity (H2A-S139 specific)
ontology: MF
definition:
Catalysis of the transfer of a phosphate group to the serine-139 residue of the C-terminal tail of histone H2A.


go_id: GO:0035981
term: tongue muscle cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a tongue muscle cell.


go_id: GO:0035983
term: response to trichostatin A
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus.


go_id: GO:0035984
term: cellular response to trichostatin A
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a trichostatin A stimulus.


go_id: GO:0035985
term: senescence-associated heterochromatin focus
ontology: CC
definition:
A transcriptionally-silent heterochromatin structure present in senescent cells. Contains the condensed chromatin of one chromosome and is enriched for histone modifications. Thought to repress expression of proliferation-promoting genes.


go_id: GO:0035987
term: endodermal cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires the specialized features of an endoderm cell, a cell of the inner of the three germ layers of the embryo.


go_id: GO:0035988
term: chondrocyte proliferation
ontology: BP
definition:
The multiplication or reproduction of chondrocytes by cell division, resulting in the expansion of their population. A chondrocyte is a polymorphic cell that forms cartilage.


go_id: GO:0035989
term: tendon development
ontology: BP
definition:
The process whose specific outcome is the progression of a tendon over time, from its formation to the mature structure. A tendon is a fibrous, strong, connective tissue that connects muscle to bone or integument and is capable of withstanding tension. Tendons and muscles work together to exert a pulling force.


go_id: GO:0035990
term: tendon cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires the specialized features of a tendon cell. Tendon cell are elongated fibrocytes in which the cytoplasm is stretched between the collagen fibres of the tendon. Tendon cells have a central cell nucleus with a prominent nucleolus, a well-developed rough endoplasmic reticulum, and are responsible for synthesis and turnover of tendon fibres and ground substance.


go_id: GO:0035991
term: nitric oxide sensor activity
ontology: MF
definition:
Binding to and responding, e.g. by conformational change, to changes in the cellular level of nitric oxide (NO).


go_id: GO:0035992
term: tendon formation
ontology: BP
definition:
The process that gives rise to a tendon. This process pertains to the initial formation of a tendon from unspecified parts.


go_id: GO:0035993
term: deltoid tuberosity development
ontology: BP
definition:
The process whose specific outcome is the progression of the deltoid tuberosity over time, from its formation to the mature structure. The deltoid tuberosity is the region on the shaft of the humerus to which the deltoid muscle attaches. The deltoid tuberosity develops through endochondral ossification in a two-phase process; an initiating tendon-dependent phase, and a muscle-dependent growth phase.


go_id: GO:0035994
term: response to muscle stretch
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a myofibril being extended beyond its slack length.


go_id: GO:0035995
term: detection of muscle stretch
ontology: BP
definition:
The series of events by which a muscle stretch stimulus is received by a cell and converted into a molecular signal.


go_id: GO:0035998
term: 7,8-dihydroneopterin 3'-triphosphate biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of 7,8-dihydroneopterin 3'-triphosphate.


go_id: GO:0035999
term: tetrahydrofolate interconversion
ontology: BP
definition:
The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesise other tetrahydrofolate molecules.


go_id: GO:0036000
term: mucocyst
ontology: CC
definition:
A small subcellular vesicle, surrounded by a membrane, in the pellicle of ciliate protozoans that discharges a mucus-like secretion.


go_id: GO:0036001
term: 'de novo' pyridoxal 5'-phosphate biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of pyridoxal 5'-phosphate, the active form of vitamin B6, from simpler components.


go_id: GO:0036002
term: pre-mRNA binding
ontology: MF
definition:
Binding to a pre-messenger RNA (pre-mRNA), an intermediate molecule between DNA and protein that may contain introns and, at least in part, encodes one or more proteins. Introns are removed from pre-mRNA to form a mRNA molecule.


go_id: GO:0036003
term: positive regulation of transcription from RNA polymerase II promoter in response to stress
ontology: BP
definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


go_id: GO:0036005
term: response to macrophage colony-stimulating factor
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus.


go_id: GO:0036006
term: cellular response to macrophage colony-stimulating factor stimulus
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a macrophage colony-stimulating factor stimulus.


go_id: GO:0036007
term: scintillon
ontology: CC
definition:
A body present in the cytoplasm of some dinoflagellates, which is the source of bioluminescence; emits light on acidification in the presence of oxygen.


go_id: GO:0036008
term: sucrose catabolic process to fructose-6-phosphate and glucose-6-phosphate
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of sucrose, which proceeds by phosphorylation of sucrose to form sucrose-6-phosphate. The subsequent actions of a hydrolase and a fructokinase generate fructose-6-phosphate and glucose-6-phosphate.


go_id: GO:0036009
term: protein-glutamine N-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + protein L-glutamine = S-adenosyl-L-homocysteine + protein N-methyl-L-glutamine.


go_id: GO:0036011
term: imaginal disc-derived leg segmentation
ontology: BP
definition:
Division of an imaginal disc-derived leg into a series of semi-repetitive parts or segments. The Drosophila leg, for example, has nine segments, each separated from the next by a flexible joint.


go_id: GO:0036012
term: cyanelle inner membrane
ontology: CC
definition:
The inner, i.e. lumen-facing, lipid bilayer of the cyanelle envelope; also faces the cyanelle stroma.


go_id: GO:0036014
term: cyanelle intermembrane space
ontology: CC
definition:
The region between the inner and outer lipid bilayers of the cyanelle envelope; includes the peptidoglycan layer.


go_id: GO:0036015
term: response to interleukin-3
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus.


go_id: GO:0036016
term: cellular response to interleukin-3
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-3 stimulus.


go_id: GO:0036017
term: response to erythropoietin
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus. Erythropoietin is a glycoprotein hormone that controls erythropoiesis.


go_id: GO:0036018
term: cellular response to erythropoietin
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an erythropoietin stimulus.


go_id: GO:0036019
term: endolysosome
ontology: CC
definition:
An transient hybrid organelle formed by fusion of a late endosome with a lysosome, and in which active degradation takes place.


go_id: GO:0036020
term: endolysosome membrane
ontology: CC
definition:
The lipid bilayer surrounding an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.


go_id: GO:0036021
term: endolysosome lumen
ontology: CC
definition:
The volume enclosed by the membrane of an endolysosome. An endolysosome is a transient hybrid organelle formed by fusion of a late endosome with a lysosome.


go_id: GO:0036022
term: limb joint morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of a limb joint are generated and organized. A limb joint is a flexible region that separates the rigid sections of a limb to allow movement in a controlled manner.


go_id: GO:0036023
term: embryonic skeletal limb joint morphogenesis
ontology: BP
definition:
The process, occurring in the embryo, in which the anatomical structures of a skeletal limb joint are generated and organized. A skeletal limb joint is the connecting structure between the bones of a limb.


go_id: GO:0036024
term: protein C inhibitor-TMPRSS7 complex
ontology: CC
definition:
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 7 (TMPRSS7); formation of the complex inhibits the serine protease activity of transmembrane protease serine 7.


go_id: GO:0036025
term: protein C inhibitor-TMPRSS11E complex
ontology: CC
definition:
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and transmembrane protease serine 11E (TMPRSS11E); formation of the complex inhibits the serine protease activity of transmembrane protease serine 11E.


go_id: GO:0036026
term: protein C inhibitor-PLAT complex
ontology: CC
definition:
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and tissue-type plasminogen activator (PLAT); formation of the complex inhibits the serine protease activity of tissue-type plasminogen activator.


go_id: GO:0036027
term: protein C inhibitor-PLAU complex
ontology: CC
definition:
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and urokinase-type plasminogen activator (PLAU); formation of the complex inhibits the serine protease activity of urokinase-type plasminogen activator.


go_id: GO:0036028
term: protein C inhibitor-thrombin complex
ontology: CC
definition:
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and thrombin (F2); formation of the complex inhibits the serine protease activity of thrombin.


go_id: GO:0036029
term: protein C inhibitor-KLK3 complex
ontology: CC
definition:
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and prostate-specific antigen (KLK3); formation of the complex inhibits the serine protease activity of prostate-specific antigen.


go_id: GO:0036030
term: protein C inhibitor-plasma kallikrein complex
ontology: CC
definition:
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and plasma kallikrein (KLK1B); formation of the complex inhibits the serine protease activity of plasma kallikrein.


go_id: GO:0036031
term: recruitment of mRNA capping enzyme to RNA polymerase II holoenzyme complex
ontology: BP
definition:
The process in which the guanylyltransferase enzyme responsible for adding a 7-methylguanosine cap on pre-mRNA becomes associated with the RNA polymerase II holoenzyme complex and the 5' end of a transcript.


go_id: GO:0036032
term: neural crest cell delamination
ontology: BP
definition:
The negative regulation of cell adhesion process in which a neural crest cell physically separates from the rest of the neural tube.


go_id: GO:0036033
term: mediator complex binding
ontology: MF
definition:
Binding to a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.


go_id: GO:0036034
term: mediator complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a mediator complex. The mediator complex is a protein complex that interacts with the carboxy-terminal domain of the largest subunit of RNA polymerase II and plays an active role in transducing the signal from a transcription factor to the transcriptional machinery. The Saccharomyces complex contains several identifiable subcomplexes: a head domain comprising Srb2, -4, and -5, Med6, -8, and -11, and Rox3 proteins; a middle domain comprising Med1, -4, and -7, Nut1 and -2, Cse2, Rgr1, Soh1, and Srb7 proteins; a tail consisting of Gal11p, Med2p, Pgd1p, and Sin4p; and a regulatory subcomplex comprising Ssn2, -3, and -8, and Srb8 proteins. Metazoan mediator complexes have similar modular structures and include homologs of yeast Srb and Med proteins.


go_id: GO:0036035
term: osteoclast development
ontology: BP
definition:
The process whose specific outcome is the progression of a osteoclast from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a specific fate. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue.


go_id: GO:0036036
term: cardiac neural crest cell delamination
ontology: BP
definition:
The negative regulation of cell adhesion process in which a cardiac neural crest cell physically separates from the rest of the neural tube.


go_id: GO:0036037
term: CD8-positive, alpha-beta T cell activation
ontology: BP
definition:
The change in morphology and behavior of a CD8-positive, alpha-beta T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


go_id: GO:0036038
term: MKS complex
ontology: CC
definition:
A protein complex that is located at the ciliary transition zone and consists of several proteins some of which are membrane bound. Acts as an organiser of transition zone inner structure, specifically the Y-shaped links, in conjunction with the NPHP complex. The MKS complex also acts as part of the selective barrier that prevents diffusion of proteins between the ciliary cytoplasm and cellular cytoplasm as well as between the ciliary membrane and plasma membrane.


go_id: GO:0036041
term: long-chain fatty acid binding
ontology: MF
definition:
Binding to a long-chain fatty acid. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.


go_id: GO:0036042
term: long-chain fatty acyl-CoA binding
ontology: MF
definition:
Binding to a long-chain fatty acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. Long-chain fatty-acyl-CoAs have chain lengths of C13 or more.


go_id: GO:0036047
term: peptidyl-lysine demalonylation
ontology: BP
definition:
The process of removing a malonyl group (CO-CH2-CO) from an malonylated lysine residue in a peptide or protein.


go_id: GO:0036049
term: peptidyl-lysine desuccinylation
ontology: BP
definition:
The removal of a succinyl group (CO-CH2-CH2-CO) from a succinylated lysine residue in a peptide or protein.


go_id: GO:0036050
term: peptidyl-lysine succinylation
ontology: BP
definition:
The modification of a peptidyl-lysine residue by the addition of a succinyl group (CO-CH2-CH2-CO) to form N6-succinyl-L-lysine.


go_id: GO:0036051
term: protein localization to trailing edge
ontology: BP
definition:
A process in which a protein is transported to, or maintained at, the trailing edge. The trailing edge is the area of a motile cell opposite to the direction of movement.


go_id: GO:0036052
term: protein localization to uropod
ontology: BP
definition:
A process in which a protein is transported to, or maintained in, a uropod. A uropod is a membrane projection with related cytoskeletal components at the trailing edge of a migrating cell.


go_id: GO:0036053
term: glomerular endothelium fenestra
ontology: CC
definition:
A large plasma membrane-lined circular pore that perforates the flattened glomerular endothelium and, unlike those of other fenestrated capillaries, is not spanned by diaphragms; the density and size of glomerular fenestrae account, at least in part, for the high permeability of the glomerular capillary wall to water and small solutes.


go_id: GO:0036054
term: protein-malonyllysine demalonylase activity
ontology: MF
definition:
Catalysis of the reaction: protein-malonyllysine + H2O => protein-lysine + malonate. This reaction is the removal of a malonyl group (CO-CH2-CO) from a malonylated lysine residue of a protein or peptide.


go_id: GO:0036055
term: protein-succinyllysine desuccinylase activity
ontology: MF
definition:
Catalysis of the reaction: H2O + N(6)-succinyl-L-lysyl-[protein] + NAD(+) = 2''-O-succinyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide.


go_id: GO:0036056
term: filtration diaphragm
ontology: CC
definition:
A specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph.


go_id: GO:0036057
term: slit diaphragm
ontology: CC
definition:
A specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.


go_id: GO:0036058
term: filtration diaphragm assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a filtration diaphragm, a specialized cell-cell junction found between the cells of the excretory system, which provides a barrier for filtration of blood or hemolymph.


go_id: GO:0036059
term: nephrocyte diaphragm assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a nephrocyte diaphragm, a specialized cell-cell junction found between nephrocytes of the insect kidney.


go_id: GO:0036060
term: slit diaphragm assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a slit diaphragm, specialized cell-cell junction found between the interdigitating foot processes of the glomerular epithelium (the podocytes) in the vertebrate kidney, which is adapted for facilitating glomerular filtration.


go_id: GO:0036061
term: muscle cell chemotaxis toward tendon cell
ontology: BP
definition:
The directed movement of a muscle cell towards a tendon cell in response to an external stimulus. Tendon cells, for example, produce positive guidance cues that attract muscle cells.


go_id: GO:0036062
term: presynaptic periactive zone
ontology: CC
definition:
A region that surrounds the active zone of the presynaptic plasma membrane, and is specialized for the control of synaptic development.


go_id: GO:0036063
term: acroblast
ontology: CC
definition:
A cone-shaped structure in the head of a spermatozoon, which is formed by the coalescence of Golgi fragments following the completion of meiosis. The acroblast is situated adjacent to the acrosomal vesicle.


go_id: GO:0036064
term: ciliary basal body
ontology: CC
definition:
A membrane-tethered, short cylindrical array of microtubules and associated proteins found at the base of a eukaryotic cilium (also called flagellum) that is similar in structure to a centriole and derives from it. The cilium basal body is the site of assembly and remodelling of the cilium and serves as a nucleation site for axoneme growth. As well as anchoring the cilium, it is thought to provide a selective gateway regulating the entry of ciliary proteins and vesicles by intraflagellar transport.


go_id: GO:0036066
term: protein O-linked fucosylation
ontology: BP
definition:
The process of transferring a fucosyl group to a serine or threonine residues in a protein acceptor molecule, to form an O-linked protein-sugar linkage.


go_id: GO:0036067
term: light-dependent chlorophyll biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the presence of light.


go_id: GO:0036068
term: light-independent chlorophyll biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of chlorophyll, any compound of magnesium complexed in a porphyrin (tetrapyrrole) ring and which functions as a photosynthetic pigment, from less complex precursors, which occur in the absence of light.


go_id: GO:0036069
term: light-dependent bacteriochlorophyll biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the presence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants.


go_id: GO:0036070
term: light-independent bacteriochlorophyll biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of a bacteriochlorophyll, which occur in the absence of light. Bacteriochlorophylls are any of the chlorophylls of photosynthetic bacteria; they differ structurally from the chlorophylls of higher plants.


go_id: GO:0036071
term: N-glycan fucosylation
ontology: BP
definition:
The process of transferring a fucosyl group to an N-glycan. An N-glycan is the carbohydrate portion of an N-glycoprotein when attached to a nitrogen from asparagine or arginine side-chains.


go_id: GO:0036072
term: direct ossification
ontology: BP
definition:
The formation of bone or of a bony substance, or the conversion of fibrous tissue or of cartilage into bone or a bony substance, that does not require the replacement of preexisting tissues.


go_id: GO:0036073
term: perichondral ossification
ontology: BP
definition:
Intramembranous ossification from the surface of a cartilage element as the perichondrium becomes a periosteum, without replacement of cartilage.


go_id: GO:0036074
term: metaplastic ossification
ontology: BP
definition:
Direct ossification in which bone formation occurs as result of the direct transformation of non-bone cells into bone cells without cell division.


go_id: GO:0036080
term: purine nucleotide-sugar transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of a purine nucleotide-sugar from one side of a membrane to the other. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative.


go_id: GO:0036081
term: extracellular ammonia-gated ion channel activity
ontology: MF
definition:
Enables the transmembrane transfer of an ion by a channel that opens when extracellular ammonia (NH3) has been bound by the channel complex or one of its constituent parts.


go_id: GO:0036082
term: extracellular phenylacetaldehyde-gated ion channel activity
ontology: MF
definition:
Enables the transmembrane transfer of an ion by a channel that opens when extracellular phenylacetaldehyde has been bound by the channel complex or one of its constituent parts.


go_id: GO:0036084
term: GDP-fucose import into endoplasmic reticulum lumen
ontology: BP
definition:
The directed movement of GDP-fucose into the endoplasmic reticulum lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate.


go_id: GO:0036085
term: GDP-fucose import into Golgi lumen
ontology: BP
definition:
The directed movement of GDP-fucose into the Golgi lumen. GDP-fucose is a substance composed of fucose in glycosidic linkage with guanosine diphosphate.


go_id: GO:0036086
ontology: BP
term:
positive regulation of transcription from RNA polymerase II promoter in response to iron ion starvation

definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions.


go_id: GO:0036087
term: glutathione synthase complex
ontology: CC
definition:
A protein complex composed of two or more polypeptide subunits, and which possesses glutathione synthase activity (catalysis of the reaction: L-gamma-glutamyl-L-cysteine + ATP + glycine = ADP + glutathione + 2 H(+) + phosphate). In eukaryotes, the complex is homodimeric, in E. coli glutathione synthase exists as a tetramer, and in S. pombe the complex exists as a homodimer or a heterotetramer.


go_id: GO:0036088
term: D-serine catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of D-serine, the D-enantiomer of serine, i.e. (2S)-2-amino-3-hydroxypropanoic acid.


go_id: GO:0036089
term: cleavage furrow formation
ontology: BP
definition:
Generation of the cleavage furrow, a shallow groove in the cell surface near the old metaphase plate that marks the site of cytokinesis. This process includes the recruitment and localized activation of signals such as RhoA at the site of the future furrow to ensure that furrowing initiates at the correct site in the cell.


go_id: GO:0036090
term: cleavage furrow ingression
ontology: BP
definition:
Advancement of the cleavage furrow from the outside of the cell inward towards the center of the cell. The cleavage furrow acts as a 'purse string' which draws tight to separate daughter cells during cytokinesis and partition the cytoplasm between the two daughter cells. The furrow ingresses until a cytoplasmic bridge is formed.


go_id: GO:0036091
ontology: BP
term:
positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress

definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals.


go_id: GO:0036092
term: phosphatidylinositol-3-phosphate biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of phosphatidylinositol-3-phosphate, a phosphatidylinositol monophosphate carrying the phosphate group at the 3-position.


go_id: GO:0036093
term: germ cell proliferation
ontology: BP
definition:
The multiplication or reproduction of germ cells, reproductive cells in multicellular organisms, resulting in the expansion of a cell population.


go_id: GO:0036100
term: leukotriene catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a leukotriene, a pharmacologically active substance derived from a polyunsaturated fatty acid, such as arachidonic acid.


go_id: GO:0036101
term: leukotriene B4 catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.


go_id: GO:0036102
term: leukotriene B4 metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.


go_id: GO:0036104
term: Kdo2-lipid A biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of Kdo2-lipid A, a lipopolysaccharide (LPS) component.


go_id: GO:0036105
term: peroxisome membrane class-1 targeting sequence binding
ontology: MF
definition:
Binding to a class I peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-dependent manner.


go_id: GO:0036106
term: peroxisome membrane class-2 targeting sequence binding
ontology: MF
definition:
Binding to a class II peroxisomal membrane targeting sequence, any of several sequences of amino acids within a protein that can act as a signal for the localization of the protein into the peroxisome membrane in a PEX19-independent manner.


go_id: GO:0036107
term: 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N).


go_id: GO:0036108
term: 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of 4-amino-4-deoxy-alpha-L-arabinopyranosyl undecaprenyl phosphate, a precursor of 4-amino-4-deoxy-L-arabinose (L-Ara4N).


go_id: GO:0036109
term: alpha-linolenic acid metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving alpha-linolenic acid, an unsaturated omega-6 fatty acid that has the molecular formula C18H32O2.


go_id: GO:0036110
term: cellular response to inositol starvation
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of inositol.


go_id: GO:0036111
term: very long-chain fatty-acyl-CoA metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22.


go_id: GO:0036112
term: medium-chain fatty-acyl-CoA metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a long-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12.


go_id: GO:0036113
term: very long-chain fatty-acyl-CoA catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of very long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A very long-chain fatty acid is a fatty acid which has a chain length greater than C22.


go_id: GO:0036114
term: medium-chain fatty-acyl-CoA catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of medium-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A medium-chain fatty acid is a fatty acid with a chain length of between C6 and C12.


go_id: GO:0036115
term: fatty-acyl-CoA catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a fatty-acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with a fatty-acyl group.


go_id: GO:0036116
term: long-chain fatty-acyl-CoA catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of long-chain fatty-acyl-CoAs, any derivative of coenzyme A in which the sulfhydryl group is in a thioester linkage with a medium-chain fatty-acyl group. A long-chain fatty acid is a fatty acid with a chain length between C13 and C22.


go_id: GO:0036117
term: hyaluranon cable
ontology: CC
definition:
A cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan.


go_id: GO:0036118
term: hyaluranon cable assembly
ontology: BP
definition:
A process that results in the aggregation, arrangement and bonding together of a hyaluranon cable, a cable structure, surrounding some cell types (e.g. proximal or bronchial tubular epithelial cells), and composed of hyaluranon (HA), a ubiquitous connective tissue glycosaminoglycan.


go_id: GO:0036119
term: response to platelet-derived growth factor
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.


go_id: GO:0036120
term: cellular response to platelet-derived growth factor stimulus
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a platelet-derived growth factor stimulus.


go_id: GO:0036121
term: double-stranded DNA helicase activity
ontology: MF
definition:
Catalysis of the reaction: ATP + H2O = ADP + phosphate, in the presence of double-stranded DNA; drives the unwinding of a DNA helix.


go_id: GO:0036123
term: histone H3-K9 dimethylation
ontology: BP
definition:
The modification of histone H3 by addition of two methyl groups to lysine at position 9 of the histone.


go_id: GO:0036124
term: histone H3-K9 trimethylation
ontology: BP
definition:
The modification of histone H3 by addition of three methyl groups to lysine at position 9 of the histone.


go_id: GO:0036125
term: fatty acid beta-oxidation multienzyme complex
ontology: CC
definition:
A multienzyme complex possessing three kinds of enzymes that catalyze the chain reactions in the fatty acid beta-oxidation cycle, enoyl-CoA hydratase (ECH), 3-hydroxyacyl-CoA dehydrogenase (HACD), and acetyl-CoA C-acyltransferase (KACT).


go_id: GO:0036126
term: sperm flagellum
ontology: CC
definition:
A microtubule-based flagellum (or cilium) that is part of a sperm, a mature male germ cell that develops from a spermatid.


go_id: GO:0036128
term: CatSper complex
ontology: CC
definition:
A sperm-specific voltage-gated calcium channel that controls the intracellular calcium ion concentration and, thereby, the swimming behavior of sperm. Consists of a heteromeric tetramer surrounding a calcium ion- selective pore. May also contain additional auxiliary subunits.


go_id: GO:0036130
term: prostaglandin H2 endoperoxidase reductase activity
ontology: MF
definition:
Catalysis of the reaction: prostaglandin H2 + NADPH + H+ -> prostaglandin F2alpha + NADP+. This reaction is the reduction of prostaglandin H2 ((5Z,13E)-(15S)-9alpha,11alpha-Epidioxy-15-hydroxyprosta-5,13-dienoate) to prostaglandin F2alpha ((5Z,13E)-(15S)-9alpha,11alpha,15-Trihydroxyprosta-5,13-dienoate).


go_id: GO:0036132
term: 13-prostaglandin reductase activity
ontology: MF
definition:
Catalysis of the reaction: 15-keto-prostaglandin + NAD(P)H + H+ -> 13,14-dihydro-15-keto-prostaglandin + NAD(P)+. This reaction is the reduction of 15-keto-prostaglandin.


go_id: GO:0036134
term: 12-hydroxyheptadecatrienoic acid synthase activity
ontology: MF
definition:
Catalysis of the reaction: prostaglandin H2 = 12-hydroxyheptadecatrienoic acid (HHT) + malonaldehyde (MDA).


go_id: GO:0036135
term: Schwann cell migration
ontology: BP
definition:
The orderly movement of a Schwann cell from one site to another. A Schwann cell is a glial cell that ensheathes axons of neuron in the peripheral nervous system and is necessary for their maintainance and function.


go_id: GO:0036136
term: kynurenine-oxaloacetate transaminase activity
ontology: MF
definition:
Catalysis of the reaction: L-kynurenine + 2-oxoglutarate = 4-(2-aminophenyl)-2,4-dioxobutanoate + L-aspartate.


go_id: GO:0036139
term: peptidyl-histidine dioxygenase activity
ontology: MF
definition:
Catalysis of the reaction: peptidyl L-histidine + 2-oxoglutarate + O2 = peptidyl hydroxy-L-histidine + succinate + CO2.


go_id: GO:0036140
term: peptidyl-asparagine 3-dioxygenase activity
ontology: MF
definition:
Catalysis of the reaction: peptidyl L-asparagine + 2-oxoglutarate + O2 = peptidyl 3-hydroxy-L-asparagine + succinate + CO2.


go_id: GO:0036143
term: kringle domain binding
ontology: MF
definition:
Binding to a kringle domain. Kringle domains are protein domains that fold into large loops stabilized by 3 disulfide linkages, and are important in protein-protein interactions with blood coagulation factors.


go_id: GO:0036145
term: dendritic cell homeostasis
ontology: BP
definition:
The process of regulating the proliferation and elimination of dendritic cells such that the total number of dendritic cells within a whole or part of an organism is stable over time in the absence of an outside stimulus.


go_id: GO:0036146
term: cellular response to mycotoxin
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a mycotoxin stimulus. A mycotoxin is a toxic chemical substance produced by fungi.


go_id: GO:0036147
term: rumination
ontology: BP
definition:
A digestive process in which food, usually grass or hay, is swallowed into a multi-compartmented stomach, regurgitated, chewed again, and swallowed again.


go_id: GO:0036148
term: phosphatidylglycerol acyl-chain remodeling
ontology: BP
definition:
Remodeling the acyl chains of phosphatidylglycerol, through sequential deacylation and re-acylation reactions, to generate phosphatidylglycerol containing different types of fatty acid acyl chains.


go_id: GO:0036149
term: phosphatidylinositol acyl-chain remodeling
ontology: BP
definition:
Remodeling the acyl chains of phosphatidylinositol, through sequential deacylation and re-acylation reactions, to generate phosphatidylinositol containing different types of fatty acid acyl chains.


go_id: GO:0036150
term: phosphatidylserine acyl-chain remodeling
ontology: BP
definition:
Remodeling the acyl chains of phosphatidylserine, through sequential deacylation and re-acylation reactions, to generate phosphatidylserine containing different types of fatty acid acyl chains.


go_id: GO:0036151
term: phosphatidylcholine acyl-chain remodeling
ontology: BP
definition:
Remodeling the acyl chains of phosphatidylcholine, through sequential deacylation and re-acylation reactions, to generate phosphatidylcholine containing different types of fatty acid acyl chains.


go_id: GO:0036152
term: phosphatidylethanolamine acyl-chain remodeling
ontology: BP
definition:
Remodeling the acyl chains of phosphatidylethanolamine, through sequential deacylation and re-acylation reactions, to generate phosphatidylethanolamine containing different types of fatty acid acyl chains.


go_id: GO:0036153
term: triglyceride acyl-chain remodeling
ontology: BP
definition:
Remodeling the acyl chains of triacylglycerol, through sequential deacylation and re-acylation reactions, to generate triacylglycerol containing different types of fatty acid acyl chains.


go_id: GO:0036154
term: diacylglycerol acyl-chain remodeling
ontology: BP
definition:
Remodeling the acyl chains of diacylglycerol, through sequential deacylation and re-acylation reactions, to generate diacylglycerol containing different types of fatty acid acyl chains.


go_id: GO:0036155
term: acylglycerol acyl-chain remodeling
ontology: BP
definition:
Remodeling the acyl chains of an acylglycerol, through sequential deacylation and re-acylation reactions, to generate an acylglycerol containing different types of fatty acid acyl chains.


go_id: GO:0036156
term: inner dynein arm
ontology: CC
definition:
Inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. The structure of inner dynein arms is complex and may vary within the axoneme. Inner dynein arms are heteromeric, comprising 8 different heavy chains and various subunits. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.


go_id: GO:0036157
term: outer dynein arm
ontology: CC
definition:
Outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes. Outer dynein arms contain 2-3 heavy chains, two or more intermediate chains and a cluster of 4-8 light chains. Inner and outer dynein arms have different functions in the generation of microtubule-based motility.


go_id: GO:0036158
term: outer dynein arm assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein outer arm, an outer arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.


go_id: GO:0036159
term: inner dynein arm assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form an axonemal dynein inner arm, an inner arm structure present on the outer doublet microtubules of ciliary and flagellar axonemes.


go_id: GO:0036160
term: melanocyte-stimulating hormone secretion
ontology: BP
definition:
The regulated release of a melanocyte-stimulating hormone, any of a group of peptide hormones that are produced by cells in the intermediate lobe of the pituitary gland, and stimulate the production of melanin to increase pigmentation.


go_id: GO:0036161
term: calcitonin secretion
ontology: BP
definition:
The regulated release of calcitonin, a peptide hormone that participates in calcium and phosphorus metabolism, from a cell.


go_id: GO:0036162
term: oxytocin production
ontology: BP
definition:
The appearance of oxytocin, a cyclic nonapeptide hormone with amino acid sequence CYIQNCPLG, due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels. Oxytocin is the principal uterine-contracting and milk-ejecting hormone of the posterior pituitary, and together with the neuropeptide vasopressin, is believed to influence social cognition and behavior. It also acts as a neurotransmitter in the brain.


go_id: GO:0036163
term: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid decarboxylase activity
ontology: MF
definition:
Catalysis of the reaction: 3-hexaprenyl-4-hydroxy-5-methoxybenzoic acid -> 2-hexaprenyl-6-methoxyphenol + CO2.


go_id: GO:0036166
term: phenotypic switching
ontology: BP
definition:
A reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations. Phenotypic switching involves changes in cell morphology and altered gene expression patterns. For example, Candida albicans switches from white cells to opaque cells for sexual mating. Phenotypic switching also occurs in multicellular organisms; smooth muscle cells (SMCs) exhibit phenotypic transitions to allow rapid adaption to fluctuating environmental cues.


go_id: GO:0036167
term: phenotypic switching in response to host
ontology: BP
definition:
A reversible switch of a cell from one phenotype to another that occurs upon infection of a host or host cell. For example, Candida albicans switches from a unicellular form to an invasive multicellular filamentous form upon infection of host tissue. Phenotypic switching begins with changes in cell morphology and altered gene expression patterns and ends when the morphology of a population of cells has reverted back to the default state, accompanied by altered expression patterns.


go_id: GO:0036168
term: filamentous growth of a population of unicellular organisms in response to heat
ontology: BP
definition:
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to an increase in temperature.


go_id: GO:0036169
term: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid decarboxylase activity
ontology: MF
definition:
Catalysis of the reaction: 3-methoxy-4-hydroxy-5-decaprenylbenzoic acid -> 2-methoxy-6-decaprenylphenol + CO2.


go_id: GO:0036170
term: filamentous growth of a population of unicellular organisms in response to starvation
ontology: BP
definition:
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to deprivation of nourishment.


go_id: GO:0036171
term: filamentous growth of a population of unicellular organisms in response to chemical stimulus
ontology: BP
definition:
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a chemical stimulus.


go_id: GO:0036175
term: ribonucleoside-diphosphate reductase activity, glutaredoxin disulfide as acceptor
ontology: MF
definition:
Catalysis of the reaction: 2'-deoxyribonucleoside diphosphate + glutaredoxin disulfide + H2O -> ribonucleoside diphosphate + glutaredoxin.


go_id: GO:0036176
term: response to neutral pH
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution.


go_id: GO:0036177
term: filamentous growth of a population of unicellular organisms in response to pH
ontology: BP
definition:
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution.


go_id: GO:0036178
term: filamentous growth of a population of unicellular organisms in response to neutral pH
ontology: BP
definition:
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a neutral pH (pH close to 7) stimulus.


go_id: GO:0036179
term: osteoclast maturation
ontology: BP
definition:
A developmental process, independent of morphogenetic (shape) change, that is required for an osteoclast cell to attain its fully functional state. An osteoclast is a specialized phagocytic cell associated with the absorption and removal of the mineralized matrix of bone tissue, and which typically differentiates from monocytes.


go_id: GO:0036180
term: filamentous growth of a population of unicellular organisms in response to biotic stimulus
ontology: BP
definition:
The process in which a group of unicellular organisms grow in a threadlike, filamentous shape in response to a biotic (living) stimulus.


go_id: GO:0036181
term: protein localization to linear element
ontology: BP
definition:
A cellular protein localization process in which a protein is transported to, or maintained at, a linear element. A linear element is a proteinaceous scaffold associated with S. pombe chromosomes during meiotic prophase.


go_id: GO:0036182
term: asperthecin metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans.


go_id: GO:0036183
term: asperthecin catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans.


go_id: GO:0036184
term: asperthecin biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of asperthecin, an anthraquinone pigment obtained from the mould Aspergillus nidulans.


go_id: GO:0036185
term: 13-lipoxin reductase activity
ontology: MF
definition:
Definition: Catalysis of the reaction: 15-oxolipoxin A4 + NAD(P)H + H+ = 13,14-dihydro-15-oxolipoxin A4 + NAD(P)+.


go_id: GO:0036187
term: cell growth mode switching, budding to filamentous
ontology: BP
definition:
The process in which a cell switches from growing as a round budding cell to growing as a filament (elongated cells attached end-to-end). An example of this is the yeast-hyphal transition of Candida albicans.


go_id: GO:0036188
term: abieta-7,13-dien-18-al dehydrogenase activity
ontology: MF
definition:
Catalysis of the reaction: abieta-7,13-diene-18-al + H2O + NAD+ = abieta-7,13-diene-18-oate + NADH + H+.


go_id: GO:0036189
term: abieta-7,13-diene hydroxylase activity
ontology: MF
definition:
Catalysis of the reaction: abieta-7,13-diene + NADPH + H+ + O2 = abieta-7,13-dien-18-ol + NADP+ + H2O.


go_id: GO:0036191
term: indolin-2-one monooxygenase activity
ontology: MF
definition:
Catalysis of the reaction: indolin-2-one + NAD(P)H + H+ + O2 = 3-hydroxyindolin-2-one + NAD(P)+ + H2O.


go_id: GO:0036192
term: 3-hydroxyindolin-2-one monooxygenase activity
ontology: MF
definition:
Catalysis of the reaction: 3-hydroxyindolin-2-one + NAD(P)H + H+ + O2 = 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O.


go_id: GO:0036193
term: 2-hydroxy-1,4-benzoxazin-3-one monooxygenase activity
ontology: MF
definition:
Catalysis of the reaction: 2-hydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)H + H+ + O2 = 2,4-dihydroxy-2H-1,4-benzoxazin-3(4H)-one + NAD(P)+ + H2O.


go_id: GO:0036194
term: muscle cell projection
ontology: CC
definition:
A prolongation or process extending from a muscle cell. A muscle cell is a mature contractile cell, commonly known as a myocyte. This cell has as part of its cytoplasm myofibrils organized in various patterns.


go_id: GO:0036197
term: zymosterol biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of zymosterol, (5alpha-cholesta-8,24-dien-3beta-ol).


go_id: GO:0036198
term: dTMP salvage
ontology: BP
definition:
Any process which produces dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate) without de novo synthesis.


go_id: GO:0036199
term: cholest-4-en-3-one 26-monooxygenase activity
ontology: MF
definition:
Catalysis of the reaction: cholest-4-en-3-one + NADH + H+ + O2 = 26-hydroxycholest-4-en-3-one + NAD+ + H2O. This reaction involves the hydroxylation of the C26 carbon, followed by oxidation of the alcohol to the carboxylic acid via the aldehyde intermediate.


go_id: GO:0036200
term: 3-ketosteroid 9-alpha-monooxygenase activity
ontology: MF
definition:
Catalysis of the reaction: androsta-1,4-diene-3,17-dione + NADH + H+ + O2 = 9alpha-hydroxyandrosta-1,4-diene-3,17-dione + NAD+ + H2O.


go_id: GO:0036201
term: ent-isokaurene C2-hydroxylase activity
ontology: MF
definition:
Catalysis of the reaction: ent-isokaurene + O2 + NADPH + H+ = ent-2alpha-hydroxyisokaurene + H2O + NADP+.


go_id: GO:0036202
term: ent-cassa-12,15-diene 11-hydroxylase activity
ontology: MF
definition:
Catalysis of the reaction: ent-cassa-12,15-diene + O2 + NADPH + H+ = ent-11beta-hydroxycassa-12,15-diene + NADP+ + H2O.


go_id: GO:0036203
term: taxoid 14-beta-hydroxylase activity
ontology: MF
definition:
Catalysis of the reaction: 10beta-hydroxytaxa-4(20),11-dien-5alpha-yl acetate + O2 + NADPH + H+ = 10beta,14beta-dihydroxytaxa-4(20),11-dien-5alpha-yl acetate + NADP+ + H2O.


go_id: GO:0036204
term: abieta-7,13-dien-18-ol hydroxylase activity
ontology: MF
definition:
Catalysis of the reaction: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18-al + NADP+ + 2 H2O. This is a two step reaction. The first step is: abieta-7,13-dien-18-ol + NADPH + H+ + O2 = abieta-7,13-dien-18,18-diol + + NADP+ + H2O. The second step is a spontaneous reaction: abieta-7,13-dien-18,18-diol = abieta-7,13-dien-18-al + H2O.


go_id: GO:0036205
term: histone catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a histone protein by individual cells.


go_id: GO:0036209
term: 9beta-pimara-7,15-diene oxidase activity
ontology: MF
definition:
Catalysis of the reaction: 9beta-pimara-7,15-diene + 3 O2 + 3 reduced [NADPH-hemoprotein reductase] = 9beta-pimara-7,15-dien-19-oate + 4 H+ + 4 H2O + 3 oxidized [NADPH-hemoprotein reductase].


go_id: GO:0036210
term: protein modification process in another organism
ontology: BP
definition:
The covalent alteration performed by one organism of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications) in another organism. Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).


go_id: GO:0036211
term: protein modification process
ontology: BP
definition:
The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).


go_id: GO:0036212
term: contractile ring maintenance
ontology: BP
definition:
The process in which the contractile ring is maintained, typically in response to an internal or external cue.


go_id: GO:0036215
term: response to stem cell factor
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus.


go_id: GO:0036216
term: cellular response to stem cell factor stimulus
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stem cell factor (SCF) stimulus.


go_id: GO:0036223
term: cellular response to adenine starvation
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of adenine.


go_id: GO:0036224
term: pairing center
ontology: CC
definition:
A special chromosome region located towards one end of a chromosome that contains dispersed copies of short, repetitive DNA sequences and functions as a cis-acting element essential for presynaptic homologous chromosome pairing and chromosome-nuclear envelope attachment.


go_id: GO:0036225
term: cellular response to vitamin B1 starvation
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of vitamin B1 (also called thiamin and thiamine).


go_id: GO:0036227
term: mitotic G2 cell cycle arrest in response to glucose starvation
ontology: BP
definition:
The process in which the mitotic cell cycle is halted during G2 phase as a result of deprivation of glucose.


go_id: GO:0036228
term: protein localization to nuclear inner membrane
ontology: BP
definition:
A process in which a protein is transported to, or maintained in, a location within the nuclear inner membrane.


go_id: GO:0036230
term: granulocyte activation
ontology: BP
definition:
The change in morphology and behavior of a granulocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.


go_id: GO:0036236
term: acyl glucuronidation
ontology: BP
definition:
The modification of an substrate by the conjugation of glucuronic acid to form an acyl-glucuronide (also called an acyl-glucuronoside).


go_id: GO:0036240
term: septal periplasm
ontology: CC
definition:
The region between the plasma membrane and the cell wall, as found in organisms such as filamentous fungi.


go_id: GO:0036242
term: glutamate catabolic process to succinate via 2-oxoglutarate-dependent GABA-transaminase activity
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of glutamate into succinate, that includes the conversion of 4-aminobutyrate to succinate semialdehyde by the 2-oxoglutarate-dependent gamma aminobutyrate (GABA) transaminase.


go_id: GO:0036244
term: cellular response to neutral pH
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a neutral pH (pH close to 7) stimulus. pH is a measure of the acidity or basicity of an aqueous solution.


go_id: GO:0036245
term: cellular response to menadione
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position.


go_id: GO:0036246
term: phytochelatin 2 import into vacuole
ontology: BP
definition:
The directed movement of phytochelatin 2 (PC2) into the vacuole. Phytochelatin 2 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=2, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond.


go_id: GO:0036247
term: phytochelatin 3 import into vacuole
ontology: BP
definition:
The directed movement of phytochelatin 3 (PC3) into the vacuole. Phytochelatin 3 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=3, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond.


go_id: GO:0036248
term: phytochelatin 4 import into vacuole
ontology: BP
definition:
The directed movement of phytochelatin 4 (PC4) into the vacuole. Phytochelatin 4 is a glutathione-related peptide composed of (gamma-Glu-Cys)n-Gly where n=4, and where the Glu and Cys residues are linked through a gamma-carboxylamide bond.


go_id: GO:0036252
term: positive regulation of transcription from RNA polymerase II promoter in response to menadione
ontology: BP
definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a menadione stimulus. Menadione (also called vitamin K3) is a naphthoquinone having a methyl substituent at the 2-position.


go_id: GO:0036253
term: response to amiloride
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus.


go_id: GO:0036254
term: cellular response to amiloride
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an amiloride stimulus.


go_id: GO:0036255
term: response to methylamine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus.


go_id: GO:0036256
term: cellular response to methylamine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylamine stimulus.


go_id: GO:0036257
term: multivesicular body organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a multivesicular body. A multivesicular body is a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.


go_id: GO:0036258
term: multivesicular body assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a multivesicular body, a type of late endosome in which regions of the limiting endosomal membrane invaginate to form internal vesicles; membrane proteins that enter the internal vesicles are sequestered from the cytoplasm.


go_id: GO:0036259
term: aerobic raffinose catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of raffinose that occur in the presence of oxygen.


go_id: GO:0036260
term: RNA capping
ontology: BP
definition:
The sequence of enzymatic reactions by which a cap structure is added to the 5' end of nascent RNA polymerase transcripts. Examples of RNA capping include 7-methyl-G caps found on all RNA polymerase II transcripts and nucleotide-containing cofactor caps, such as NAD(H) or FAD, found on bacterial trancripts.


go_id: GO:0036261
term: 7-methylguanosine cap hypermethylation
ontology: BP
definition:
Hypermethylation of the 7-(mono)methylguanosine (m(7)G) cap structure at the 2' position of the guanosine residue to convert a mono-methylated cap to a 2,2,7-trimethylguanosine cap structure. This type of cap modification occurs on small nuclear RNAs (snRNAs) and small nucleolar RNAs (snoRNAs) and is dependent on prior guanine-N7 methylation.


go_id: GO:0036262
term: granulysin production
ontology: BP
definition:
The appearance of granulysin due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0036265
term: RNA (guanine-N7)-methylation
ontology: BP
definition:
The addition of a methyl group to the N7 atom in the base portion of a guanine nucleotide residue in an RNA molecule.


go_id: GO:0036266
term: Cdc48p-Npl4p-Vms1p AAA ATPase complex
ontology: CC
definition:
A multiprotein ATPase complex involved in the release of polyubiquitinated proteins, including those damaged by oxidative stress, from the outer mitochondria membrane into the cytoplasm where they are presented to the proteasome for proteolysis, a process also referred to as mitochondria-associated degradation (MAD). In budding yeast, this complex includes Cdc48p, Npl4p and Vms1p.


go_id: GO:0036268
term: swimming
ontology: BP
definition:
Self-propelled movement of an organism from one location to another through water, often by means of active fin movement.


go_id: GO:0036269
term: swimming behavior
ontology: BP
definition:
The response to external or internal stimuli that results in the locomotory process of swimming. Swimming is the self-propelled movement of an organism through the water.


go_id: GO:0036270
term: response to diuretic
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a diuretic stimulus. A diuretic is an agent that promotes the excretion of urine through its effects on kidney function.


go_id: GO:0036271
term: response to methylphenidate
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylphenidate stimulus.


go_id: GO:0036272
term: response to gemcitabine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gemcitabine stimulus. Gemcitabine is a 2'-deoxycytidine having geminal fluoro substituents in the 2'-position, and is used as a drug in the treatment of various carcinomas.


go_id: GO:0036273
term: response to statin
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a statin stimulus. Statins are organooxygen compounds whose structure is related to compactin (mevastatin) and which may be used as an anticholesteremic drug due its EC:1.1.1.34/EC:1.1.1.88 (hydroxymethylglutaryl-CoA reductase) inhibitory properties.


go_id: GO:0036274
term: response to lapatinib
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lapatinib stimulus.


go_id: GO:0036275
term: response to 5-fluorouracil
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluorouracil stimulus.


go_id: GO:0036276
term: response to antidepressant
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antidepressant stimulus, a mood-stimulating drug.


go_id: GO:0036277
term: response to anticonvulsant
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an anticonvulsant stimulus, a drug used to prevent seizures or reduce their severity.


go_id: GO:0036278
ontology: BP
term:
positive regulation of transcription from RNA polymerase II promoter in response to nitrogen starvation

definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a deprivation of nitrogen.


go_id: GO:0036279
term: positive regulation of protein export from nucleus in response to glucose starvation
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of directed movement of proteins from the nucleus into the cytoplasm in response to deprivation of glucose.


go_id: GO:0036280
term: cellular response to L-canavanine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-canavanine stimulus. L-canavanine is L-homoserine substituted at oxygen with a guanidino (carbamimidamido) group.


go_id: GO:0036284
term: tubulobulbar complex
ontology: CC
definition:
Actin-based structures involved in establishing close contact between Sertoli-Sertoli cells or Sertoli-spermatids in the seminiferous tubules of the testes.


go_id: GO:0036285
term: SAGA complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a SAGA complex, a SAGA-type histone acetyltransferase complex that contains Spt8 (in budding yeast) or a homolog thereof.


go_id: GO:0036287
term: response to iloperidone
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an iloperidone stimulus.


go_id: GO:0036288
term: response to ximelagatran
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ximelagatran stimulus.


go_id: GO:0036289
term: peptidyl-serine autophosphorylation
ontology: BP
definition:
The phosphorylation by a protein of one or more of its own serine amino acid residues, or a serine residue on an identical protein.


go_id: GO:0036290
term: protein trans-autophosphorylation
ontology: BP
definition:
The phosphorylation by a protein of a residue on an identical protein. For example, phosphorylation by the other kinase within a homodimer.


go_id: GO:0036292
term: DNA rewinding
ontology: BP
definition:
The process in which interchain hydrogen bonds between two single-stranded DNA (ssDNA) are reformed to regenerate double-stranded DNA (dsDNA). ssDNA is often bound and stabilized by proteins such as replication protein A (RPA) to form ssDNA bubbles. The bubbles can be rewound by ATP-dependent motors to reform base pairs between strands and thus dsDNA.


go_id: GO:0036293
term: response to decreased oxygen levels
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.


go_id: GO:0036294
term: cellular response to decreased oxygen levels
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting a decline in the level of oxygen.


go_id: GO:0036295
term: cellular response to increased oxygen levels
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen.


go_id: GO:0036296
term: response to increased oxygen levels
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus reflecting an increase in the level of oxygen.


go_id: GO:0036297
term: interstrand cross-link repair
ontology: BP
definition:
Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA. DNA interstrand crosslinks occur when both strands of duplex DNA are covalently tethered together (e.g. by an exogenous or endogenous agent), thus preventing the strand unwinding necessary for essential DNA functions such as transcription and replication.


go_id: GO:0036298
term: recombinational interstrand cross-link repair
ontology: BP
definition:
Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that involves the exchange, reciprocal or nonreciprocal, of genetic material between the broken DNA molecule and a homologous DNA region.


go_id: GO:0036299
term: non-recombinational interstrand cross-link repair
ontology: BP
definition:
Removal of a DNA interstrand crosslink (a covalent attachment of DNA bases on opposite strands of the DNA) and restoration of the DNA by a mechanism that does not involve homologous DNA recombination.


go_id: GO:0036300
term: B cell receptor internalization
ontology: BP
definition:
A receptor-mediated endocytosis process that results in the movement of a B cell receptor from the plasma membrane to the inside of the cell.


go_id: GO:0036301
term: macrophage colony-stimulating factor production
ontology: BP
definition:
The appearance of macrophage colony-stimulating factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0036302
term: atrioventricular canal development
ontology: BP
definition:
The progression of the atrioventricular canal over time, from its formation to the mature structure. The atrioventricular canal is the part of the heart connecting the atrium to the cardiac ventricle.


go_id: GO:0036303
term: lymph vessel morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of lymph vessels are generated and organized. The lymph vessel is the vasculature carrying lymph.


go_id: GO:0036304
term: umbilical cord morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the umbilical cord are generated and organized. The umbilical cord is an organ or embryonic origin consisting of the 2 umbilical arteries and the one umbilical vein. The umbilical cord connects the cardiovascular system of the fetus to the mother via the placenta.


go_id: GO:0036305
term: ameloblast differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of an ameloblast, a cylindrical epithelial cell in the innermost layer of the enamel organ.


go_id: GO:0036306
term: embryonic heart tube elongation
ontology: BP
definition:
The developmental growth that results in the increase in length of the embryonic heart tube. The embryonic heart tube is an epithelial tube that will give rise to the mature heart.


go_id: GO:0036307
term: 23S rRNA (adenine(2030)-N(6))-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + adenine(2030) in 23S rRNA = S-adenosyl-L-homocysteine + rRNA containing N(6)-methyladenine(2030) in 23S rRNA.


go_id: GO:0036308
term: 16S rRNA (guanine(1516)-N(2))-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + guanosine(1516) in 16S rRNA = N(2)-methylguanosine(1516) in 16S rRNA + S-adenosyl-L-homocysteine.


go_id: GO:0036309
term: protein localization to M-band
ontology: BP
definition:
Any process in which a protein is transported to, and/or maintained in, the M band. The M band is the midline of aligned thick filaments in a sarcomere.


go_id: GO:0036310
term: ATP-dependent DNA/DNA annealing activity
ontology: MF
definition:
An ATP-dependent activity that facilitates the formation of a complementary double-stranded DNA molecule.


go_id: GO:0036311
term: chitin disaccharide deacetylase activity
ontology: MF
definition:
Catalysis of the reaction: 2-(acetylamino)-4-O-[2-(acetylamino)-2-deoxy-beta-D-glucopyranosyl]-2-deoxy-beta-D-glucopyranose + H2O = 2-(acetylamino)-4-O-(2-amino-2-deoxy-beta-D-glucopyranosyl)-2-deoxy-beta-D-glucopyranose + acetate.


go_id: GO:0036312
term: phosphatidylinositol 3-kinase regulatory subunit binding
ontology: MF
definition:
Binding to a regulatory subunit of phosphatidylinositol 3-kinase. The regulatory subunit associates with the catalytic subunit to regulate both its activity and subcellular location.


go_id: GO:0036313
term: phosphatidylinositol 3-kinase catalytic subunit binding
ontology: MF
definition:
Binding to the catalytic subunit of a phosphatidylinositol 3-kinase. The catalytic subunit catalyzes the addition of a phosphate group to an inositol lipid at the 3' position of the inositol ring.


go_id: GO:0036314
term: response to sterol
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus.


go_id: GO:0036315
term: cellular response to sterol
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a sterol stimulus.


go_id: GO:0036316
term: SREBP-SCAP complex retention in endoplasmic reticulum
ontology: BP
definition:
Any process in which the SREBP-SCAP complex is maintained in the endoplasmic reticulum and prevented from moving elsewhere. The SREBP-SCAP complex is formed by the association of sterol regulatory element binding protein (SREBP) and SREBP-cleavage-activating protein (SCAP). In the absence of sterols, the SREBP-SCAP complex is packaged into COPII vesicles and travels to the Golgi apparatus to be processed. In the presence of sterols, the complex binds ER-resident proteins such as INSIG, which retain the complex in the ER.


go_id: GO:0036317
term: tyrosyl-RNA phosphodiesterase activity
ontology: MF
definition:
Catalysis of the hydrolysis of a 5' tyrosyl-RNA phosphodiester bond between a protein and RNA. In picornaviruses, this covalent bond connects VPg, a viral-encoded protein essential for RNA replication, to the 5' end of all nascent picornavirus genomes; it is cleaved from viral RNA prior to its engaging in protein synthesis.


go_id: GO:0036318
term: peptide pheromone receptor activity
ontology: MF
definition:
Combining with a peptide pheromone, and transmitting the signal across the membrane to initiate a change in cell activity.


go_id: GO:0036319
term: mating-type M-factor pheromone receptor activity
ontology: MF
definition:
Combining with the mating-type peptide pheromone M-factor and transmitting the signal across the membrane to initiate a change in cell activity. M-factor is a nine-membered oligopeptide that consists of tyrosyl, threonyl, prolyl, lysyl, valyl, prolyl, tyrosyl, methionyl and methyl S-farnesylcysteinate residues joined in sequence, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Minus.


go_id: GO:0036320
term: mating-type P-factor pheromone receptor activity
ontology: MF
definition:
Combining with the mating-type peptide pheromone P-factor and transmitting the signal across the membrane to initiate a change in cell activity. P-factor is a polypeptide of 23 residues, with the sequence Thr-Tyr-Ala-Asp-Phe-Leu-Arg-Ala-Tyr-Gln-Ser-Trp-Asn-Thr-Phe-Val-Asn-Pro-Asp-Arg-Pro-Asn-Leu, and is a peptide pheromone released by Schizosaccharomyces pombe cells of the cellular mating type Plus.


go_id: GO:0036321
term: ghrelin secretion
ontology: BP
definition:
The regulated release of ghrelin from a cell. Ghrelin is a 28 amino acid hunger-stimulating peptide hormone.


go_id: GO:0036322
term: pancreatic polypeptide secretion
ontology: BP
definition:
The regulated release of pancreatic polypeptide (PP) from a cell. Pancreatic polypeptide is a 36 amino acid polypeptide secreted by islets of Langerhans cells in the pancreas.


go_id: GO:0036323
term: vascular endothelial growth factor receptor-1 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-1 (VEGFR-1) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0036324
term: vascular endothelial growth factor receptor-2 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-2 (VEGFR-2) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0036325
term: vascular endothelial growth factor receptor-3 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a ligand binding to a vascular endothelial growth factor receptor-3 (VEGFR-3) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0036331
term: avascular cornea development in camera-type eye
ontology: BP
definition:
The progression of an avascular cornea over time, from its formation to the mature structure. Corneal avascularity (the absence of blood vessels in the cornea) is required for optical clarity and optimal vision. Avascular corneas are present in most animals, except Manatees.


go_id: GO:0036332
term: placental growth factor receptor activity
ontology: MF
definition:
Combining with placental growth factor (PlGF) receptor ligand and transmitting the signal across the plasma membrane to initiate a change in cell activity.


go_id: GO:0036333
term: hepatocyte homeostasis
ontology: BP
definition:
Any biological process involved in the maintenance of the steady-state number of hepatocytes within a population of cells. Hepatocytes are specialized epithelial cells of the liver that are organized into interconnected plates called lobules.


go_id: GO:0036334
term: epidermal stem cell homeostasis
ontology: BP
definition:
Any biological process involved in the maintenance of the steady-state number of epidermal stem cells within a population of cells.


go_id: GO:0036335
term: intestinal stem cell homeostasis
ontology: BP
definition:
Any biological process involved in the maintenance of the steady-state number of intestinal stem cells within a population of cells.


go_id: GO:0036337
term: Fas signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of a ligand to a Fas receptor on the surface of the cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Fas is a death domain-containing member of the tumor necrosis factor receptor (TNFR) superfamily.


go_id: GO:0036339
term: lymphocyte adhesion to endothelial cell of high endothelial venule
ontology: BP
definition:
The attachment of a lymphocyte to an endothelial cell of a high endothelial venule (HEV) via adhesion molecules. A HEV cell is an endothelial cell that is cuboidal, expresses leukocyte-specific receptors, and allows for passage of lymphocytes into bloodstream.


go_id: GO:0036340
term: chitin-based cuticle sclerotization by biomineralization
ontology: BP
definition:
The process of hardening a chitin-based cuticle by mineral incorporation. For example, the cuticle of crustaceans is hardened by the incorporation of calcium carbonate.


go_id: GO:0036341
term: chitin-based cuticle sclerotization by protein cross-linking
ontology: BP
definition:
The process of hardening of a chitin-based cuticle by protein cross-linking, and the incorporation of phenolic precursors. This mechanism of cuticle hardening occurs in insects and is usually accompanied by darkening of the cuticle.


go_id: GO:0036342
term: post-anal tail morphogenesis
ontology: BP
definition:
The process in which a post-anal tail is generated and organized. A post-anal tail is a muscular region of the body that extends posterior to the anus. The post-anal tail may aid locomotion and balance.


go_id: GO:0036343
term: psychomotor behavior
ontology: BP
definition:
The specific behavior of an organism that combines cognitive functions and physical movement. For example, driving a car, throwing a ball, or playing a musical instrument.


go_id: GO:0036344
term: platelet morphogenesis
ontology: BP
definition:
Generation and organization of a platelet, a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.


go_id: GO:0036345
term: platelet maturation
ontology: BP
definition:
A developmental process, independent of morphogenetic (shape) change, that is required for a platelet to attain its fully functional state. A platelet is a non-nucleated disk-shaped cell formed by extrusion from megakaryocytes, found in the blood of all mammals, and mainly involved in blood coagulation.


go_id: GO:0036346
term: cellular response to L-cysteine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a L-cysteine stimulus. L-cysteine is an optically active form of cysteine having L-configuration.


go_id: GO:0036349
term: galactose-specific flocculation
ontology: BP
definition:
The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to galactose residues on the other.


go_id: GO:0036350
term: mannose-specific flocculation
ontology: BP
definition:
The non-sexual aggregation of single-celled organisms mediated by the binding of cell wall proteins on one cell to mannose residues on the other.


go_id: GO:0036351
term: histone H2A-K13 ubiquitination
ontology: BP
definition:
The modification of histone H2A by addition of ubiquitin group at lysine 13 (H2A-K13) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K13 and K63-linked ubiquitin chains are then extended from this monoubiquitin.


go_id: GO:0036352
term: histone H2A-K15 ubiquitination
ontology: BP
definition:
The modification of histone H2A by addition of ubiquitin group at lysine 15 (H2A-K15) in metazoans, and at the equivalent residue in other organisms. Monoubiquitin is first attached to H2A-K15 and K63-linked ubiquitin chains are then extended from this monoubiquitin.


go_id: GO:0036353
term: histone H2A-K119 monoubiquitination
ontology: BP
definition:
The modification of histone H2A by addition of a single ubiquitin group to lysine-119 (H2A- K119) in metazoans, and at the equivalent residue in other organisms.


go_id: GO:0036354
term: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a dehydrogenase activity
ontology: MF
definition:
Catalysis of the reaction: 2-desacetyl-2-hydroxyethyl bacteriochlorophyllide a = bacteriochlorophyllide a + 2 H+.


go_id: GO:0036355
term: 2-iminoacetate synthase activity
ontology: MF
definition:
Catalysis of the reaction: L-tyrosine + S-adenosyl-L-methionine + reduced acceptor = 2-iminoacetate + 4-methylphenol + 5'-deoxyadenosine + L-methionine + acceptor + 2 H+.


go_id: GO:0036356
term: cyclic 2,3-diphosphoglycerate synthetase activity
ontology: MF
definition:
Catalysis of the reaction: 2,3-diphosphoglycerate (DPG) + ATP = cyclic 2,3-diphosphoglycerate (cDPG) + ADP + phosphate.


go_id: GO:0036358
term: lipoteichoic acid D-alanylation
ontology: BP
definition:
The formation of a D-alanyl ester of lipoteichoic acid by transfer of D-Ala onto a membrane-associated lipoteichoic acid (LTA).


go_id: GO:0036359
term: renal potassium excretion
ontology: BP
definition:
The elimination of potassium ions from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine.


go_id: GO:0036360
term: sorocarp stalk morphogenesis
ontology: BP
definition:
The process in which the sorocarp stalk is generated and organized. The sorocarp stalk is a tubular structure that consists of cellulose-covered cells stacked on top of each other and surrounded by an acellular stalk tube composed of cellulose and glycoprotein. An example of this process is found in Dictyostelium discoideum.


go_id: GO:0036361
term: racemase activity, acting on amino acids and derivatives
ontology: MF
definition:
Catalysis of the interconversion of the two enantiomers of a chiral amino acid or amino acid derivative.


go_id: GO:0036362
term: ascus membrane
ontology: CC
definition:
A double layer of lipid molecules that surrounds an ascus, a capsule containing the sexual spores in some fungi.


go_id: GO:0036363
term: transforming growth factor beta activation
ontology: BP
definition:
The release of transforming growth factor beta (TGF-beta) from its latent state. TGF-beta is secreted as part of a large latent complex (LLC) that is targeted to the extracellular matrix. Release of TGFbeta from its latent state is required for TGFbeta to bind to its receptors, and can occur by a variety of mechanisms.


go_id: GO:0036368
term: cone photoresponse recovery
ontology: BP
definition:
The processes required for a cone photoreceptor to recover, following light activation, so that it can respond to a subsequent light stimulus. Cone recovery requires the shutoff of active participants in the phototransduction cascade, including the visual pigment and downstream signal transducers.


go_id: GO:0036369
term: transcription factor catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a sequence-specific DNA-binding transcription factor by hydrolysis of its peptide bonds, initiated by the covalent attachment of ubiquitin, and mediated by the proteasome.


go_id: GO:0036370
term: D-alanyl carrier activity
ontology: MF
definition:
Binding a D-alanine and presenting it for processing or offloading to a cognate enzyme. Covalently binds the D-alanine via a phosphopantetheine prosthetic group and mediates protein-protein interactions with the enzyme conferring specificity. The carrier protein provides an essential link between the D-alanine-D-alanyl carrier protein ligase and the incorporation of D-alanine into lipoteichoic acid by transferring activated D-alanine to cell membrane phosphatidylglycerol (PG).


go_id: GO:0036371
term: protein localization to T-tubule
ontology: BP
definition:
A process in which a protein is transported to, or maintained in, the T-tubule. The T-tubule is an invagination of the plasma membrane of a muscle cell that extends inward from the cell surface around each myofibril.


go_id: GO:0036372
term: opsin transport
ontology: BP
definition:
The directed movement of an opsin (a G protein-coupled receptor of photoreceptor cells) into, out of or within a cell, or between cells, or within a multicellular organism by means of some agent such as a transporter or pore.


go_id: GO:0036375
term: Kibra-Ex-Mer complex
ontology: CC
definition:
An apical protein complex that contains the proteins Kibra, Expanded and Merlin (Mer), or orthologs thereof. In humans, the complex contains KIBRA, FDM6 and NF2.


go_id: GO:0036376
term: sodium ion export across plasma membrane
ontology: BP
definition:
The directed movement of sodium ions from inside of a cell, across the plasma membrane and into the extracellular region.


go_id: GO:0036377
term: arbuscular mycorrhizal association
ontology: BP
definition:
A form of mutualism between a fungus and the roots of a vascular plant, where hyphae of the fungus penetrate the plant cell wall and invaginate its cell membrane. Once inside, the fungus forms highly branched structures for nutrient exchange with the plant called arbuscules. Aids in the acquisition by the plant of nutrients such as phosphorus from the soil.


go_id: GO:0036378
term: calcitriol biosynthetic process from calciol
ontology: BP
definition:
Conversion of vitamin D3 from its largely inactive form (calciol, also called cholecalciferol) into a hormonally active form (calcitriol). Conversion requires 25-hydroxylation of calciol in the liver to form calcidiol, and subsequent 1,alpha-hydroxylation of calcidiol in the kidney to form calcitriol.


go_id: GO:0036380
term: UDP-N-acetylglucosamine-undecaprenyl-phosphate N-acetylglucosaminephosphotransferase activity
ontology: MF
definition:
Catalysis of the reaction: UDP-N-acetyl-alpha-D-glucosamine + ditrans,octacis-undecaprenyl phosphate = UMP + N-acetyl-alpha-D-glucosaminyldiphospho-ditrans,octacis-undecaprenol.


go_id: GO:0036381
term: pyridoxal 5'-phosphate synthase (glutamine hydrolysing) activity
ontology: MF
definition:
Catalysis of the reaction: D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + L-glutamine = pyridoxal 5'-phosphate + L-glutamate + 3 H2O + phosphate. The reaction occurs in two steps: L-glutamine + H2O = L-glutamate + NH3, and subsequently D-ribose 5-phosphate + D-glyceraldehyde 3-phosphate + NH3 = pyridoxal 5'-phosphate + 4 H2O + phosphate.


go_id: GO:0036383
term: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione monooxygenase activity
ontology: MF
definition:
Catalysis of the reaction: 3-hydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMNH2 + O2 = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + FMN + H2O.


go_id: GO:0036386
term: bacterial nucleoid packaging
ontology: BP
definition:
A process in which chromosomal DNA and associated proteins organize into a compact, orderly bacterial nucleoid. Often resulting in DNA supercoiling.


go_id: GO:0036387
term: pre-replicative complex
ontology: CC
definition:
A protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication.


go_id: GO:0036388
term: pre-replicative complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form the pre-replicative complex, a protein-DNA complex that forms at the origin of replication during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication.


go_id: GO:0036389
term: bacterial pre-replicative complex
ontology: CC
definition:
A protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication.


go_id: GO:0036390
term: pre-replicative complex assembly involved in bacterial-type DNA replication
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form the bacterial pre-replicative complex, a protein-DNA complex that forms at the bacterial oriC during the initial step of DNA replication and allows the origin to become competent, or 'licensed', for replication.


go_id: GO:0036391
term: medial cortex septin ring
ontology: CC
definition:
A ring-shaped structure that forms at the medial cortex of a symmetrically dividing cell at the onset of cytokinesis; composed of members of the conserved family of filament forming proteins called septins as well as septin-associated proteins.


go_id: GO:0036392
term: chemokine (C-C motif) ligand 20 production
ontology: BP
definition:
The appearance of chemokine (C-C motif) ligand 20 (CCL20) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0036393
term: thiocyanate peroxidase activity
ontology: MF
definition:
Catalysis of the reaction: thiocyanate (SCN-) + hydrogen peroxide (H2O2) = hypothiocyanite (OSCN-) + 2 H2O. Catalyzes the hydrogen peroxide oxidation of thiocyanate.


go_id: GO:0036396
term: RNA N6-methyladenosine methyltransferase complex
ontology: CC
definition:
A RNA methyltransferase complex that catalyzes the post-transcriptional methylation of adenosine to form N6-methyladenosine (m6A). In budding yeast, the MIS complex consists of Mum2p, Ime4p and Slz1p. In vertebrates, the complex consists of METTL3, METTL14 and associated components WTAP, ZC3H13, VIRMA, CBLL1/HAKAI and in some cases of RBM15 (RBM15 or RBM15B).


go_id: GO:0036398
term: TCR signalosome
ontology: CC
definition:
A multi-protein complex containing at least the T-cell receptor complex and the LAT (linker for activation of T cells) scaffold protein. Also contains a variety of signaling proteins including co-receptors, kinases, phosphatases and adaptors such as CD8. Connects events on the plasma membrane to distal signaling cascades to ultimately modulate T cell biology.


go_id: GO:0036400
term: short neuropeptide F receptor activity
ontology: MF
definition:
Combining with a short neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Short neuropeptide F is an arthropod peptide of less than 28 residues (as small as 8-10 residues in some species) with a C-terminal RFamide or LRFamide.


go_id: GO:0036401
term: pyrokinin receptor activity
ontology: MF
definition:
Combining with a pyrokinin and transmitting the signal within the cell to induce a change in cell activity. Pyrokinins are a group of insect neuropeptides that share the common C-terminal pentapeptide sequence Phe-X-Pro-Arg-Leu-NH2 (X = S, T, K, A, or G). They play a central role in diverse physiological processes including stimulation of gut motility, production and release of sex pheromones, diapause, and pupariation.


go_id: GO:0036402
term: proteasome-activating activity
ontology: MF
definition:
Catalysis of the reaction: ATP + H2O = ADP + phosphate, which promotes unfolding of protein substrates, and channel opening of the core proteasome.


go_id: GO:0036403
term: arachidonate 8(S)-lipoxygenase activity
ontology: MF
definition:
Catalysis of the reaction: arachidonate + O(2) = (5Z,8S,9E,11Z,14Z)-8-hydroperoxyicosa-5,9,11,14-tetraenoate.


go_id: GO:0036405
term: anchored component of cell outer membrane
ontology: CC
definition:
The component of the cell outer membrane consisting of the gene products that are tethered to the membrane only by a covalently attached anchor, such as a lipid group embedded in the membrane. Gene products with peptide sequences that are embedded in the membrane are excluded from this grouping.


go_id: GO:0036406
term: anchored component of periplasmic side of cell outer membrane
ontology: CC
definition:
The component of the cell outer membrane consisting of gene products and protein complexes that are tethered to the periplasmic side of membrane by only a covalently attached anchor, embedded in the periplasmic side of the membrane only.


go_id: GO:0036407
term: mycolate outer membrane
ontology: CC
definition:
A mycolic acid-rich cell outer membrane containing a lipid bilayer and long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network. Found in mycobacteria and related genera (e.g. corynebacteria).


go_id: GO:0036408
term: histone acetyltransferase activity (H3-K14 specific)
ontology: MF
definition:
Catalysis of the reaction: acetyl-CoA + histone H3 L-lysine (position 14) = CoA + histone H3 N6-acetyl-L-lysine (position 14).


go_id: GO:0036410
term: Mst2 histone acetyltransferase complex
ontology: CC
definition:
A protein complex that can catalyze the acetylation of lysine at position 14 in histone H3, and contains Mst2 as the catalytic subunit. In fission yeast, contains at least Mst2, Nto1, Ptf2, Ptf1 and Eaf6.


go_id: GO:0036411
term: H-NS-Cnu complex
ontology: CC
definition:
A trimeric protein complex containing a H-NS homodimer and a Cnu monomer. In bacteria, this complex negatively regulates transcription of a range of genes.


go_id: GO:0036415
term: regulation of tRNA stability
ontology: BP
definition:
Any process that modulates the propensity of transfer RNA (tRNA) molecules to degradation. Includes processes that both stabilize and destabilize tRNAs.


go_id: GO:0036417
term: tRNA destabilization
ontology: BP
definition:
Any process that decreases the stability of a tRNA molecule, making it more vulnerable to degradative processes.


go_id: GO:0036418
term: intrinsic component of mycolate outer membrane
ontology: CC
definition:
The component of the mycolate outer membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0036419
term: integral component of mycolate outer membrane
ontology: CC
definition:
The component of the mycolate outer membrane consisting of the gene products having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0036420
term: extrinsic component of mycolate outer membrane
ontology: CC
definition:
The component of mycolate outer membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0036421
term: extrinsic component of external side of mycolate outer membrane
ontology: CC
definition:
The component of mycolate membrane consisting of gene products and protein complexes that are loosely bound to its external surface, but not integrated into the hydrophobic region.


go_id: GO:0036423
term: hexaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) activity
ontology: MF
definition:
Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 3 isopentenyl diphosphate = 3 diphosphate + all-trans-hexaprenyl diphosphate.


go_id: GO:0036426
term: ditrans, polycis-undecaprenyl-phosphate mannosyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: ditrans,octacis-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate+ GDP.


go_id: GO:0036427
term: all-trans-undecaprenyl-phosphate mannosyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: all-trans-undecaprenyl phosphate + GDP-alpha-D-mannose = D-mannosyl undecaprenyl phosphate + GDP.


go_id: GO:0036433
term: di-trans, poly-cis-undecaprenol kinase activity
ontology: MF
definition:
Catalysis of the reaction: di-trans, octa-cis-undecaprenol + ATP = di-trans,octa-cis-undecaprenyl phosphate + ADP + H+.


go_id: GO:0036434
term: nitronate monooxygenase (FMN-linked) activity
ontology: MF
definition:
Catalysis of the reaction: ethylnitronate + FMNH(2) + O(2) = acetaldehyde + FMN + H(2)O + H(+) + nitrite.


go_id: GO:0036435
term: K48-linked polyubiquitin modification-dependent protein binding
ontology: MF
definition:
Binding to a protein upon poly-ubiquitination formed by linkages between lysine residues at position 48 in the target protein.


go_id: GO:0036436
term: Isw1a complex
ontology: CC
definition:
An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc3p.


go_id: GO:0036437
term: Isw1b complex
ontology: CC
definition:
An Isw1 complex that binds DNA and has nucleosome-stimulated ATPase activity. In S. cerevisiae, contains an Isw1p ATPase subunit in complex with Ioc2p and Ioc4p.


go_id: GO:0036438
term: maintenance of lens transparency
ontology: BP
definition:
A homeostatic process in which the lens is maintained in a highly refractive, transparent state to allow for optimal focusing of light on the retina.


go_id: GO:0036443
term: dermatan 6-sulfotransferase activity
ontology: MF
definition:
Catalysis of the reaction: 3'-phosphoadenylyl sulfate + dermatan = adenosine 3',5'-bisphosphate + dermatan 6'-sulfate.


go_id: GO:0036444
term: calcium import into the mitochondrion
ontology: BP
definition:
A process in which a calcium ion (Ca2+) is transported from the cytosol into the mitochondrial matrix.


go_id: GO:0036447
term: cellular response to sugar-phosphate stress
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of sugar-phosphate.


go_id: GO:0036448
term: cellular response to glucose-phosphate stress
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the accumulation of glucose-phosphate.


go_id: GO:0036450
term: polyuridylation-dependent decapping of nuclear-transcribed mRNA
ontology: BP
definition:
Cleavage of the 5'-cap of a nuclear-transcribed mRNA that has been modified by the enzymatic addition of a sequence of uridylyl residues (polyuridylation) at the 3' end.


go_id: GO:0036452
term: ESCRT complex
ontology: CC
definition:
An endosomal sorting complex involved in membrane fission processes related to sorting of multivesicular bodies (MVB) in the endocytic pathway, cytokinesis and viral budding among other processes.


go_id: GO:0036453
term: transitive RNA interference
ontology: BP
definition:
An RNA interference where the silencing signal spreads along the target mRNA in a 5' or 3' direction, outside of the initial target sequence.


go_id: GO:0036456
term: L-methionine-(S)-S-oxide reductase activity
ontology: MF
definition:
Catalysis of the reaction: L-methionine (S)-S-oxide + thioredoxin -> L-methionine + thioredoxin disulfide + H2O.


go_id: GO:0036457
term: keratohyalin granule
ontology: CC
definition:
A cytoplasmic, non-membrane bound granule of, at least, keratinocyte. Associated to keratin intermediate filaments and partially crosslinked to the cell envelope.


go_id: GO:0036460
term: cellular response to cell envelope stress
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of stress acting at the cell envelope.


go_id: GO:0036461
term: BLOC-2 complex binding
ontology: MF
definition:
Binding to a BLOC-2 complex, a protein complex required for the biogenesis of specialized organelles of the endosomal-lysosomal system, such as melanosomes and platelet dense granules.


go_id: GO:0036462
term: TRAIL-activated apoptotic signaling pathway
ontology: BP
definition:
An extrinsic apoptotic signaling pathway initiated by the binding of the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) to a death receptor on the cell surface.


go_id: GO:0036463
term: TRAIL receptor activity
ontology: MF
definition:
Combining with the ligand TRAIL (tumor necrosis factor-related apoptosis-inducing ligand) and transmitting the signal from one side of the plasma membrane to the other to initiate apoptotic cell death.


go_id: GO:0036465
term: synaptic vesicle recycling
ontology: BP
definition:
The trafficking of synaptic vesicles from the pre-synaptic membrane so the vesicle can dock and prime for another round of exocytosis and neurotransmitter release. Recycling occurs after synaptic vesicle exocytosis, and is necessary to replenish presynaptic vesicle pools, sustain transmitter release and preserve the structural integrity of the presynaptic membrane. Recycling can occur following transient fusion with the presynaptic membrane (kiss and run), or via endocytosis of presynaptic membrane.


go_id: GO:0036466
term: synaptic vesicle recycling via endosome
ontology: BP
definition:
Synaptic vesicle recycling where vesicles endocytosed via clathrin-coated pits re-acidify and refill with neurotransmitters after passing through an endosomal intermediate.


go_id: GO:0036471
term: cellular response to glyoxal
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a glyoxal stimulus.


go_id: GO:0036472
term: suppression by virus of host protein-protein interaction
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of interaction between host proteins.


go_id: GO:0036473
term: cell death in response to oxidative stress
ontology: BP
definition:
Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to an oxidative stress stimulus.


go_id: GO:0036474
term: cell death in response to hydrogen peroxide
ontology: BP
definition:
Any biological process that results in permanent cessation of all vital functions of a cell upon exposure to hydrogen peroxide (H2O2).


go_id: GO:0036475
term: neuron death in response to oxidative stress
ontology: BP
definition:
Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to an oxidative stress stimulus.


go_id: GO:0036476
term: neuron death in response to hydrogen peroxide
ontology: BP
definition:
Any biological process that results in permanent cessation of all vital functions of a neuron upon exposure to hydrogen peroxide (H2O2).


go_id: GO:0036477
term: somatodendritic compartment
ontology: CC
definition:
The region of a neuron that includes the cell body (cell soma) and dendrite(s), but excludes the axon.


go_id: GO:0036480
term: neuron intrinsic apoptotic signaling pathway in response to oxidative stress
ontology: BP
definition:
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, and ends when the execution phase of apoptosis is triggered.


go_id: GO:0036481
term: intrinsic apoptotic signaling pathway in response to hydrogen peroxide
ontology: BP
definition:
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway is induced in response to hydrogen peroxide (H2O2).


go_id: GO:0036482
term: neuron intrinsic apoptotic signaling pathway in response to hydrogen peroxide
ontology: BP
definition:
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron in response to hydrogen peroxide.


go_id: GO:0036483
term: neuron intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
ontology: BP
definition:
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a neuron. The pathway is induced in response to a stimulus indicating endoplasmic reticulum (ER) stress, and ends when the execution phase of apoptosis is triggered. ER stress usually results from the accumulation of unfolded or misfolded proteins in the ER lumen.


go_id: GO:0036484
term: trunk neural crest cell migration
ontology: BP
definition:
The characteristic movement of trunk neural crest cells from the neural tube to other locations in the vertebrate embryo.


go_id: GO:0036485
term: dorsolateral trunk neural crest cell migration
ontology: BP
definition:
The movement of trunk neural crest cells from the neural tube, travelling dorso-laterally into the ectoderm and continuing toward the ventral midline of the belly. These migrating trunk neural crest cells become melanocytes, the melanin-forming pigment cells.


go_id: GO:0036486
term: ventral trunk neural crest cell migration
ontology: BP
definition:
The movement of trunk neural crest cells from the neural tube, travelling ventrally through the anterior half of each sclerotome. Trunk neural crest cells that remain in the sclerotome form the dorsal root ganglia containing the sensory neurons. Trunk neural crest cells that continue more ventrally form the sympathetic ganglia, the adrenal medulla, and the nerve clusters surrounding the aorta.


go_id: GO:0036488
term: CHOP-C/EBP complex
ontology: CC
definition:
A heterodimeric protein complex that is composed of the transcription factor CHOP (GADD153) and a member of the C/EBP family of transcription factors.


go_id: GO:0036489
term: neuromelanin biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of neuromelanin. Neuromelanin is a polymer of 5,6-dihydroxyindole monomers.


go_id: GO:0036490
term: regulation of translation in response to endoplasmic reticulum stress
ontology: BP
definition:
Modulation of the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.


go_id: GO:0036491
term: regulation of translation initiation in response to endoplasmic reticulum stress
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of translation initiation, as a result of endoplasmic reticulum stress.


go_id: GO:0036492
term: eiF2alpha phosphorylation in response to endoplasmic reticulum stress
ontology: BP
definition:
The addition of a phosphate group on to the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress.


go_id: GO:0036493
term: positive regulation of translation in response to endoplasmic reticulum stress
ontology: BP
definition:
Any process that activates, or increases the frequency, rate or extent of translation as a result of endoplasmic reticulum stress.


go_id: GO:0036494
term: positive regulation of translation initiation in response to endoplasmic reticulum stress
ontology: BP
definition:
Any process that activates, or increases the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress.


go_id: GO:0036495
term: negative regulation of translation initiation in response to endoplasmic reticulum stress
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of translation initiation as a result of endoplasmic reticulum stress.


go_id: GO:0036496
term: regulation of translational initiation by eIF2 alpha dephosphorylation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of translation initiation in response to stress by the dephosphorylation of eIF2 alpha.


go_id: GO:0036497
term: eIF2alpha dephosphorylation in response to endoplasmic reticulum stress
ontology: BP
definition:
The removal of a phosphate group from the translation initiation factor eIF2alpha, as a result of endoplasmic reticulum stress.


go_id: GO:0036498
term: IRE1-mediated unfolded protein response
ontology: BP
definition:
The series of molecular signals mediated by the endoplasmic reticulum stress sensor IRE1 (Inositol-requiring transmembrane kinase/endonuclease). Begins with activation of IRE1 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. One target of activated IRE1 is the transcription factor HAC1 in yeast, or XBP1 in mammals; IRE1 cleaves an intron of a mRNA coding for HAC1/XBP1 to generate an activated HAC1/XBP1 transcription factor, which controls the up regulation of UPR-related genes. At least in mammals, IRE1 can also signal through additional intracellular pathways including JNK and NF-kappaB.


go_id: GO:0036499
term: PERK-mediated unfolded protein response
ontology: BP
definition:
The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor PERK (PKR-like ER kinase). Begins with activation of PERK in response to endoplasmic reticulum (ER) stress and ends with regulation of a downstream cellular process, e.g. transcription. The main substrate of PERK is the translation initiation factor eIF2alpha. Serine-phosphorylation of eIF2alpha by PERK inactivates eIF2alpha and inhibits general protein translation. In addition, eIF2alpha phosphorylation preferentially increases the translation of selective mRNAs such as ATF4 (activating transcription factor 4), which up regulates a subset of UPR genes required to restore folding capacity.


go_id: GO:0036500
term: ATF6-mediated unfolded protein response
ontology: BP
definition:
The series of molecular signals mediated by the endoplasmic reticulum membrane stress sensor ATF6 (activating transcription factor 6). Begins with activation of ATF6 in response to endoplasmic reticulum (ER) stress, and ends with regulation of a downstream cellular process, e.g. transcription. Under conditions of endoplasmic reticulum stress, ATF6 translocates to the Golgi where it is processed by proteases to release a cytoplasmic domain (ATF6f), which operates as a transcriptional activator of many genes required to restore folding capacity.


go_id: GO:0036501
term: UFD1-NPL4 complex
ontology: CC
definition:
A dimeric protein complex that contains the co-factors for the ATPase VCP/p97 (Cdc48p in budding yeast). In mammals, this complex consists of UFD1L (UFD1) and NPLOC4 (NPL4). In budding yeast, the complex is a dimer of Ufd1p and Npl4p.


go_id: GO:0036502
term: Derlin-1-VIMP complex
ontology: CC
definition:
A protein complex containing, in mammals, Derlin-1 and VCP-interacting membrane protein (VIMP). The complex links the p97/VCP-containing ATPase complex with Derlin-1 during translocation of protein substrates from the endoplasmic reticulum to the cytosol for degradation by the cytosolic proteasome.


go_id: GO:0036503
term: ERAD pathway
ontology: BP
definition:
The protein catabolic pathway which targets endoplasmic reticulum (ER)-resident proteins for degradation by the cytoplasmic proteasome. It begins with recognition of the ER-resident protein, includes retrotranslocation (dislocation) of the protein from the ER to the cytosol, protein modifications necessary for correct substrate transfer (e.g. ubiquitination), transport of the protein to the proteasome, and ends with degradation of the protein by the cytoplasmic proteasome.


go_id: GO:0036504
term: Golgi membrane fusion
ontology: BP
definition:
The joining of two lipid bilayers that surround the Golgi apparatus to form a single Golgi membrane.


go_id: GO:0036505
term: prosaposin receptor activity
ontology: MF
definition:
Combining with prosaposin to initiate a change in cell activity. Prosaposin is the glycoprotein precursor of four cleavage products (saposins A, B, C and D).


go_id: GO:0036509
term: trimming of terminal mannose on B branch
ontology: BP
definition:
The removal of an alpha-1,2-linked mannose from the B-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.


go_id: GO:0036510
term: trimming of terminal mannose on C branch
ontology: BP
definition:
The removal of an alpha-1,2-linked mannose from the C-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.


go_id: GO:0036511
term: trimming of first mannose on A branch
ontology: BP
definition:
The removal of the first alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.


go_id: GO:0036512
term: trimming of second mannose on A branch
ontology: BP
definition:
The removal of the second alpha-1,2-linked mannose from the A-chain of a glycoprotein oligosaccharide in the endoplasmic reticulum.


go_id: GO:0036513
term: Derlin-1 retrotranslocation complex
ontology: CC
definition:
A protein complex that functions in the retrotranslocation step of ERAD (ER-associated protein degradation), and includes at its core Derlin-1 oligomers forming a retrotranslocation channel.


go_id: GO:0036514
term: dopaminergic neuron axon guidance
ontology: BP
definition:
The chemotaxis process that directs the migration of an axon growth cone of a dopaminergic neuron to a specific target site in response to a combination of attractive and repulsive cues.


go_id: GO:0036515
term: serotonergic neuron axon guidance
ontology: BP
definition:
The chemotaxis process that directs the migration of an axon growth cone of a serotonergic neuron to a specific target site in response to a combination of attractive and repulsive cues.


go_id: GO:0036516
term: chemoattraction of dopaminergic neuron axon
ontology: BP
definition:
The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal.


go_id: GO:0036517
term: chemoattraction of serotonergic neuron axon
ontology: BP
definition:
The process in which a serotonergic neuron growth cone is directed to a specific target site in response to an attractive chemical signal.


go_id: GO:0036518
term: chemorepulsion of dopaminergic neuron axon
ontology: BP
definition:
The process in which a dopaminergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.


go_id: GO:0036519
term: chemorepulsion of serotonergic neuron axon
ontology: BP
definition:
The process in which a serotonergic neuron growth cone is directed to a specific target site in response to a repulsive chemical cue.


go_id: GO:0036520
term: astrocyte-dopaminergic neuron signaling
ontology: BP
definition:
Cell-cell signaling that mediates the transfer of information from an astrocyte to a dopaminergic neuron.


go_id: GO:0036521
term: modulation by symbiont of host protein localization to phagocytic vesicle
ontology: BP
definition:
Any process in which an organism modulates the frequency, rate or extent of protein localisation to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction.


go_id: GO:0036522
term: negative regulation by symbiont of host protein localization to phagocytic vesicle
ontology: BP
definition:
Any process in which an organism stops, prevents, or reduces the frequency, rate or extent of protein localisation to the host phagosome. The host is defined as the larger of the organisms involved in a symbiotic interaction.


go_id: GO:0036531
term: glutathione deglycation
ontology: BP
definition:
The removal of a sugar or dicarbonyl from glycated glutathione. Glutathione is the tripeptide glutamylcysteinylglycine.


go_id: GO:0038001
term: paracrine signaling
ontology: BP
definition:
The transfer of information from one cell to another, where the signal travels from the signal-producing cell to the receiving cell by passive diffusion or bulk flow in intercellular fluid. The signaling cell and the receiving cell are usually in the vicinity of each other.


go_id: GO:0038002
term: endocrine signaling
ontology: BP
definition:
The transfer of information from one cell to another, where an endocrine hormone is transported from the signal-producing cell to the receiving cell via the circulatory system (via blood, lymph or cerebrospinal fluid). The signaling cell and the receiving cell are often distant to each other.


go_id: GO:0038003
term: G protein-coupled opioid receptor signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway initiated by an opioid binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


go_id: GO:0038004
term: epidermal growth factor receptor ligand maturation
ontology: BP
definition:
Any process leading to the attainment of the full functional capacity of a ligand for an epidermal growth factor receptor. The ligand is functional when it can bind to and activate an epidermal growth factor receptor.


go_id: GO:0038006
term: netrin receptor activity involved in chemoattraction
ontology: MF
definition:
Combining with a netrin signal and transmitting the signal from one side of the membrane to the other to contribute to the directed movement of a motile cell towards a higher concentration of netrin.


go_id: GO:0038007
term: netrin-activated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of a netrin protein to its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Netrins can act as chemoattractant signals for some cells and chemorepellent signals for others. Netrins also have roles outside of cell and axon guidance.


go_id: GO:0038008
term: TRAF-mediated signal transduction
ontology: BP
definition:
The intracellular process in which a signal is passed on to downstream components within the cell via a tumor necrosis factor receptor-associated factor (TRAF). TRAFs are directly or indirectly recruited to the intracellular domains of cell surface receptors, and engage other signaling proteins to transfer the signal from a cell surface receptor to other intracellular signaling components.


go_id: GO:0038009
term: regulation of signal transduction by receptor internalization
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of signal transduction by the movement of a signaling receptor from the plasma membrane to the inside of the cell. Receptor internalization can have a positive or negative effect on a signaling pathway.


go_id: GO:0038010
term: positive regulation of signal transduction by receptor internalization
ontology: BP
definition:
Any process in which the internalization of a signaling receptor activates or increases the frequency, rate or extent of signal transduction. Receptor internalization can enhance signaling by concentrating signaling molecules in one location, or by moving a ligand-activated receptor to the location of downstream signaling proteins. Endosomes for example can serve as important intracellular signaling platforms.


go_id: GO:0038011
term: negative regulation of signal transduction by receptor internalization
ontology: BP
definition:
Any process in which internalization of a signaling receptor stops, prevents, or reduces the frequency, rate or extent of signal transduction. Receptor internalization can attenuate or reduce the strength of signaling by reducing the concentration of cell surface receptors available to ligands.


go_id: GO:0038012
term: negative regulation of Wnt signaling pathway by Wnt receptor internalization
ontology: BP
definition:
Any process in which internalization of a Wnt receptor stops, prevents, or reduces the frequency, rate or extent of Wnt signal transduction.


go_id: GO:0038013
term: positive regulation of Wnt signaling pathway by Wnt receptor internalization
ontology: BP
definition:
Any process in which internalization of a Wnt receptor activates or increases the frequency, rate or extent of the Wnt signaling pathway.


go_id: GO:0038014
term: negative regulation of insulin receptor signaling pathway by insulin receptor internalization
ontology: BP
definition:
Any process in which internalization of an insulin receptor stops, prevents, or reduces the frequency, rate or extent of insulin receptor signal transduction. Internalization of insulin in association with its receptor clears insulin from the circulation and is necessary for subsequent insulin dissociation from the receptor and insulin degradation.


go_id: GO:0038015
term: positive regulation of insulin receptor signaling pathway by insulin receptor internalization
ontology: BP
definition:
Any process in which internalization of an insulin receptor activates or increases the frequency, rate or extent of the insulin receptor signaling pathway. Endocytosis of activated receptors can concentrate receptors within endosomes and allow the insulin receptor to phosphorylate substrates that are spatially distinct from those accessible at the plasma membrane.


go_id: GO:0038016
term: insulin receptor internalization
ontology: BP
definition:
A receptor-mediated endocytosis process that results in the movement of an insulin receptor from the plasma membrane to the inside of the cell.


go_id: GO:0038017
term: Wnt receptor internalization
ontology: BP
definition:
A receptor-mediated endocytosis process that results in the movement of a Wnt receptor from the plasma membrane to the inside of the cell.


go_id: GO:0038018
term: Wnt receptor catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a Wnt receptor. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation.


go_id: GO:0038019
term: Wnt receptor recycling
ontology: BP
definition:
The process that results in the return of a Wnt receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive a Wnt signal. Internalized Wnt receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation.


go_id: GO:0038020
term: insulin receptor recycling
ontology: BP
definition:
The process that results in the return of an insulin receptor to an active state at the plasma membrane. An active state is when the receptor is ready to receive an insulin signal. Internalized insulin receptors can be recycled to the plasma membrane or sorted to lysosomes for protein degradation.


go_id: GO:0038021
term: leptin receptor activity
ontology: MF
definition:
Combining with the fat-cell specific hormone leptin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0038022
term: G protein-coupled olfactory receptor activity
ontology: MF
definition:
Combining with an odorant and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


go_id: GO:0038023
term: signaling receptor activity
ontology: MF
definition:
Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.


go_id: GO:0038024
term: cargo receptor activity
ontology: MF
definition:
Binding specifically to a substance (cargo) to deliver it to a transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.


go_id: GO:0038025
term: reelin receptor activity
ontology: MF
definition:
Combining with the secreted glycoprotein reelin, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0038026
term: reelin-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of reelin (a secreted glycoprotein) to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038027
term: apolipoprotein A-I-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by apolipoprotein A-I binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038028
term: insulin receptor signaling pathway via phosphatidylinositol 3-kinase
ontology: BP
definition:
An insulin receptor signaling pathway in which the signal is transmitted via the phosphatidylinositol 3-kinase cascade.


go_id: GO:0038029
term: epidermal growth factor receptor signaling pathway via MAPK cascade
ontology: BP
definition:
An epidermal growth factor receptor signaling pathway in which the signal is transmitted via the MAPKKK cascade.


go_id: GO:0038030
term: non-canonical Wnt signaling pathway via MAPK cascade
ontology: BP
definition:
The series of molecular signals initiated by a Wnt protein binding to a frizzled family receptor on the surface of a target cell, where the signal is passed on via the MAPKKK cascade.


go_id: GO:0038031
term: non-canonical Wnt signaling pathway via JNK cascade
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, where the signal is passed on via the JNK cascade.


go_id: GO:0038032
term: termination of G protein-coupled receptor signaling pathway
ontology: BP
definition:
The signaling process in which G protein-coupled receptor signaling is brought to an end. For example, through the action of GTPase-activating proteins (GAPs) that act to accelerate hydrolysis of GTP to GDP on G-alpha proteins, thereby terminating the transduced signal.


go_id: GO:0038033
ontology: BP
term:
positive regulation of endothelial cell chemotaxis by VEGF-activated vascular endothelial growth factor receptor signaling pathway

definition:
The series of molecular signals initiated by the binding of a vascular endothelial growth factor (VEGF) to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of endothelial cell chemotaxis.


go_id: GO:0038034
term: signal transduction in absence of ligand
ontology: BP
definition:
The series of molecular signals initiated by the absence of a ligand or the withdrawal of a ligand from a receptor.


go_id: GO:0038035
term: G protein-coupled receptor signaling in absence of ligand
ontology: BP
definition:
The series of molecular signals beginning with a consequence of a G protein-coupled receptor promoting the exchange of GDP for GTP on the alpha-subunit of an associated heterotrimeric G-protein complex, where the G protein-coupled receptor is not bound to an agonist.


go_id: GO:0038036
term: sphingosine-1-phosphate receptor activity
ontology: MF
definition:
Combining with the sphingolipid sphingosine-1-phosphate (S1P), and transmitting the signal across the membrane by activating an associated G-protein.


go_id: GO:0038038
term: G protein-coupled receptor homodimeric complex
ontology: CC
definition:
A protein complex that contains two G protein-coupled receptors (GPCRs) of the same subtype. Formation of a GPCR homodimer may be important for the transport of newly formed receptors to the cell surface, and the function of the receptor.


go_id: GO:0038039
term: G protein-coupled receptor heterodimeric complex
ontology: CC
definition:
A protein complex that contains two G protein-coupled receptors (GPCRs) of different subtypes. Formation of a GPCR heterodimer may alter the functional property of the GPCR.


go_id: GO:0038041
term: cross-receptor inhibition within G protein-coupled receptor heterodimer
ontology: BP
definition:
Inhibition of one protomer of a G protein-coupled receptor (GPCR) heterodimer by the associated subunit. For example, agonist activation of one cytokine receptor can prevent activation of its associated cytokine receptor subunit.


go_id: GO:0038043
term: interleukin-5-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-5 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038045
term: large latent transforming growth factor-beta complex
ontology: CC
definition:
A protein complex containing latency-associated proteins (LAPs), mature disulphide-linked dimeric TGF-beta, and latent TGF-beta binding proteins (LTBPs). TGF-beta is mostly secreted as part of the large latent complex, and must be subsequently released from the LLC in order to bind to cell surface receptors.


go_id: GO:0038046
term: G protein-coupled enkephalin receptor activity
ontology: MF
definition:
Combining with an enkephalin, and transmitting the signal across the membrane by activating an associated G-protein. A enkephalin is a pentapeptide (Tyr-Gly-Gly-Phe-Met or Tyr-Gly-Gly-Phe-Leu) involved in regulating nociception in the body.


go_id: GO:0038047
term: morphine receptor activity
ontology: MF
definition:
Combining with morphine (17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol), and transmitting the signal across the membrane by activating an associated G-protein.


go_id: GO:0038048
term: dynorphin receptor activity
ontology: MF
definition:
Combining with a dynorphin peptide, and transmitting the signal across the membrane by activating an associated G-protein. Dynorphin is any opioid peptide that is generated by cleavage of the precursor protein prodynorphin.


go_id: GO:0038054
term: G protein-coupled estrogen receptor activity
ontology: MF
definition:
Combining with estrogen and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


go_id: GO:0038056
term: negative regulation of BMP signaling pathway by negative regulation of BMP secretion
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the BMP signaling pathway by stopping, preventing or reducing the frequency, rate or extent of secretion of a member of the BMP family of proteins from the signaling cell.


go_id: GO:0038057
term: TNFSF11 binding
ontology: MF
definition:
Binding to tumor necrosis factor ligand superfamily member 11 (TNFSF11), a member of the tumor necrosis factor (TNF) cytokine family.


go_id: GO:0038058
term: TNFSF11 receptor activity
ontology: MF
definition:
Combining with a tumor necrosis factor ligand superfamily member 11 (TNFSF11) and transmitting the signal across the cell membrane to initiate a change in cell activity or function.


go_id: GO:0038060
term: nitric oxide-cGMP-mediated signaling pathway
ontology: BP
definition:
Any intracellular signal transduction in which the signal is passed on within the cell by nitric oxide (NO) activating soluble guanylyl cyclase (sGC). Includes synthesis of nitric oxide, guanylyl cyclase activity, and downstream effectors that further transmit the signal within the cell following activation by cGMP.


go_id: GO:0038061
term: NIK/NF-kappaB signaling
ontology: BP
definition:
The process in which a signal is passed on to downstream components within the cell through the NIK-dependent processing and activation of NF-KappaB. Begins with activation of the NF-KappaB-inducing kinase (NIK), which in turn phosphorylates and activates IkappaB kinase alpha (IKKalpha). IKKalpha phosphorylates the NF-Kappa B2 protein (p100) leading to p100 processing and release of an active NF-KappaB (p52).


go_id: GO:0038062
term: protein tyrosine kinase collagen receptor activity
ontology: MF
definition:
Combining with collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-tyrosine = ADP + a protein-L-tyrosine phosphate.


go_id: GO:0038063
term: collagen-activated tyrosine kinase receptor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by collagen binding to its receptor on the surface of a target cell where the receptor possesses tyrosine kinase activity, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038064
term: collagen receptor activity
ontology: MF
definition:
Combining with a collagen and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0038065
term: collagen-activated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by collagen binding to a cell surface receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038066
term: p38MAPK cascade
ontology: BP
definition:
An intracellular protein kinase cascade containing at least a p38 MAPK, a MAPKK and a MAP3K. The cascade can also contain an additional tier: the upstream MAP4K. The kinases in each tier phosphorylate and activate the kinases in the downstream tier to transmit a signal within a cell.


go_id: GO:0038083
term: peptidyl-tyrosine autophosphorylation
ontology: BP
definition:
The phosphorylation by a protein of one or more of its own tyrosine amino acid residues, or a tyrosine residue on an identical protein.


go_id: GO:0038084
term: vascular endothelial growth factor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding its receptor on the surface of the target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038086
term: VEGF-activated platelet-derived growth factor receptor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038087
term: VEGF-activated platelet-derived growth factor receptor-alpha signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to an alpha-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038088
term: VEGF-activated platelet-derived growth factor receptor-beta signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a beta-type platelet-derived growth factor receptor (PDGFR) on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038089
term: positive regulation of cell migration by vascular endothelial growth factor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to its receptor on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another.


go_id: GO:0038090
ontology: BP
term:
positive regulation of cell migration by VEGF-activated platelet derived growth factor receptor signaling pathway

definition:
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of the orderly movement of a cell from one site to another.


go_id: GO:0038091
ontology: BP
term:
positive regulation of cell proliferation by VEGF-activated platelet derived growth factor receptor signaling pathway

definition:
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a platelet-derived growth factor receptor (PDGFR) on the surface of a cell, which activates or increases the frequency, rate or extent of cell proliferation.


go_id: GO:0038092
term: nodal signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by nodal protein binding to an activin receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038093
term: Fc receptor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of the Fc portion of an immunoglobulin to an Fc receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.


go_id: GO:0038094
term: Fc-gamma receptor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin G (IgG) to an Fc-gamma receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.


go_id: GO:0038095
term: Fc-epsilon receptor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of the Fc portion of immunoglobulin E (IgE) to an Fc-epsilon receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. The Fc portion of an immunoglobulin is its C-terminal constant region.


go_id: GO:0038096
term: Fc-gamma receptor signaling pathway involved in phagocytosis
ontology: BP
definition:
An Fc-gamma receptor signaling pathway that contributes to the endocytic engulfment of external particulate material by phagocytes.


go_id: GO:0038097
term: positive regulation of mast cell activation by Fc-epsilon receptor signaling pathway
ontology: BP
definition:
An Fc-epsilon receptor signaling pathway that results in the change in morphology and behavior of a mast cell resulting from exposure to a cytokine, chemokine, soluble factor, or to (at least in mammals) an antigen which the mast cell has specifically bound via IgE bound to Fc-epsilonRI receptors.


go_id: GO:0038098
term: sequestering of BMP from receptor via BMP binding
ontology: BP
definition:
Binding to a bone morphogenetic protein (BMP) in the extracellular region, and inhibiting BMP signaling by preventing BMP from binding to its cell surface receptor.


go_id: GO:0038099
term: nodal receptor complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a complex containing a type II activin receptor, a type I activin receptor, and a coreceptor of the EGF-CFC family (e.g. Cripto or Cryptic, in mammals).


go_id: GO:0038101
term: sequestering of nodal from receptor via nodal binding
ontology: BP
definition:
Binding to a nodal protein in the extracellular region, and inhibiting nodal signaling by preventing nodal from binding to its cell surface receptor.


go_id: GO:0038102
term: activin receptor antagonist activity
ontology: MF
definition:
Interacting with an activin receptor complex to reduce the action of another ligand, the agonist. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor.


go_id: GO:0038103
term: activin receptor antagonist activity involved in negative regulation of nodal signaling pathway
ontology: MF
definition:
Interacting with an activin receptor to reduce the action of the agonist nodal. A receptor antagonist does not initiate signaling upon binding to a receptor, but instead blocks an agonist from binding to the receptor.


go_id: GO:0038104
term: nodal receptor complex
ontology: CC
definition:
A protein complex containing at least a type II activin receptor, a type I activin receptor, and a coreceptor (EGF-CFC protein) such as Cripto or Cryptic. Nodal receptor complexes are capable of binding a nodal protein and transducing the signal into the cell.


go_id: GO:0038105
term: sequestering of TGFbeta from receptor via TGFbeta binding
ontology: BP
definition:
Binding to a transforming growth factor-beta (TGFbeta) protein in the extracellular region, and inhibiting TGFbeta signaling by preventing TGFbeta from binding to its cell surface receptor.


go_id: GO:0038106
term: choriogonadotropin hormone binding
ontology: MF
definition:
Binding to choriogonadotropin hormone, a heterodimer, with an alpha subunit identical to that of luteinizing hormone (LH), follicle-stimulating hormone (FSH) and thyroid-stimulating hormone (TSH), and a unique beta subunit.


go_id: GO:0038107
term: nodal signaling pathway involved in determination of left/right asymmetry
ontology: BP
definition:
The series of molecular signals initiated by a nodal protein binding of to an activin receptor on the surface of a target cell, which contributes to the establishment of an organism's body plan or part of an organism with respect to the left and right halves.


go_id: GO:0038108
term: negative regulation of appetite by leptin-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by leptin binding to its receptor on the surface of a cell, which reduces appetite, the desire or physical craving for food.


go_id: GO:0038109
term: Kit signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of stem cell factor to the tyrosine kinase receptor KIT on the surface of a target cell, and ending with regulation of a downstream cellular process, e.g. transcription. Stem cell factor (KIT ligand) binding to the receptor Kit mediates receptor dimerization, activation of its intrinsic tyrosine kinase activity and autophosphorylation. The activated receptor then phosphorylates various substrates, thereby activating distinct signaling cascades within the cell that trigger a change in state or activity of the cell.


go_id: GO:0038110
term: interleukin-2-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-2 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038111
term: interleukin-7-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-7 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038112
term: interleukin-8-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-8 binding to its receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038113
term: interleukin-9-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-9 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038114
term: interleukin-21-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-21 binding to a receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038115
term: chemokine (C-C motif) ligand 19 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of the C-C chemokine CCL19 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038116
term: chemokine (C-C motif) ligand 21 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038117
term: C-C motif chemokine 19 receptor activity
ontology: MF
definition:
Combining with the C-C motif chemokine 19 (CCL19) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0038118
term: C-C chemokine receptor CCR7 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a the C-C chemokine type 7 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038119
term: CCL19-activated CCR7 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of the C-C chemokine CCL19 to a C-C chemokine type 7 receptor (CCR7) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038120
term: CCL21-activated CCR7 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of the C-C chemokine CCL21 to a C-C chemokine type 7 receptor (CCR7) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038121
term: C-C motif chemokine 21 receptor activity
ontology: MF
definition:
Combining with the C-C motif chemokine 21 (CCL21) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0038122
term: C-C motif chemokine 5 receptor activity
ontology: MF
definition:
Combining with the C-C motif chemokine 5 (CCL5) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0038123
term: toll-like receptor TLR1:TLR2 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a ligand binding of a heterodimeric TLR1:TLR2 complex, followed by transmission of the signal by the activated receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038124
term: toll-like receptor TLR6:TLR2 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a ligand binding of a heterodimeric TLR6:TLR2 complex, followed by transmission of the signal by the activated receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038127
term: ERBB signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by binding of a ligand to a member of the ERBB family of receptor tyrosine kinases on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038128
term: ERBB2 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB2 on the surface of a cell. The pathway ends with regulation of a downstream cellular process, e.g. transcription. ERBB2 receptors are themselves unable to bind to ligands, but act as a signal-amplifying tyrosine kinase within a heterodimeric pair.


go_id: GO:0038129
term: ERBB3 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB3 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription. ERBB3 receptors have impaired kinase activity and rely on the kinase activity of the heterodimer partner for activation and signal transmission.


go_id: GO:0038130
term: ERBB4 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4 on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038131
term: neuregulin receptor activity
ontology: MF
definition:
Combining with a neuregulin, a member of the EGF family of growth factors, and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0038133
term: ERBB2-ERBB3 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by binding of a ligand to a ERBB3 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3. ERBB3 also has impaired kinase activity and relies on ERBB2 for activation and signal transmission.


go_id: GO:0038134
term: ERBB2-EGFR signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by binding of a ligand to an epidermal growth factor receptor (EGFR/ERBB1) on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and EGFR. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR.


go_id: GO:0038135
term: ERBB2-ERBB4 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by binding of a ligand to a ERBB4 receptor on the surface of a cell, followed by transmission of the signal by a heterodimeric complex of ERBB2 and ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4.


go_id: GO:0038136
term: ERBB3-ERBB4 signaling pathway
ontology: BP
definition:
The series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors ERBB3 and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038137
term: ERBB4-EGFR signaling pathway
ontology: BP
definition:
The series of molecular signals transmitted by a heterodimeric complex of the tyrosine kinase receptors EGFR (epidermal growth factor receptor/ERBB1) and ERBB4. The pathway begins with binding of a ligand to either cell surface receptor, or the dimeric receptor complex, and ends with regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038138
term: ERBB4-ERBB4 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by binding of a ligand to the tyrosine kinase receptor ERBB4, followed by ligand-induced homodimerization of ERBB4 and transmission of the signal into the cell by the homodimeric ERBB4 complex. The pathway ends with regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038139
term: ERBB4-EGFR complex
ontology: CC
definition:
A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and epidermal growth factor receptor (EGFR/ERBB1).


go_id: GO:0038140
term: ERBB4-ERBB3 complex
ontology: CC
definition:
A heterodimeric complex between the tyrosine kinase receptors ERBB4 (also called HER4) and ERBB3 (also called HER3). ERBB3 has impaired kinase activity so relies on the kinase activity of its heterodimer partner for activation and signal transmission.


go_id: GO:0038141
term: ERBB4-ERBB4 complex
ontology: CC
definition:
A homodimeric complex containing two monomers of the tyrosine kinase receptor ERBB4 (also called HER4).


go_id: GO:0038142
term: EGFR:ERBB2 complex
ontology: CC
definition:
A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated epidermal growth factor receptor (EGFR/ERBB1). ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as EGFR.


go_id: GO:0038143
term: ERBB3:ERBB2 complex
ontology: CC
definition:
A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB3. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB3.


go_id: GO:0038144
term: ERBB4:ERBB2 complex
ontology: CC
definition:
A heterodimeric complex between the tyrosine kinase receptor ERBB2 and a ligand-activated receptor ERBB4. ERBB2, which does not bind any known ligand, is activated through formation of a heterodimer with another ligand-activated ERBB family member such as ERBB4.


go_id: GO:0038145
term: macrophage colony-stimulating factor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of the cytokine macrophage colony-stimulating factor (M-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038146
term: chemokine (C-X-C motif) ligand 12 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of the chemokine CXCL12 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038147
term: C-X-C motif chemokine 12 receptor activity
ontology: MF
definition:
Combining with the C-X-C motif chemokine 12 (CXCL12) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0038148
term: chemokine (C-C motif) ligand 2 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038149
term: C-C motif chemokine 2 receptor activity
ontology: MF
definition:
Combining with the C-C motif chemokine 2 (CCL2) and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0038150
term: C-C chemokine receptor CCR2 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR2) on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038151
term: CCL2-activated CCR2 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 2 receptor (CCR2) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038152
term: C-C chemokine receptor CCR4 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a the C-C chemokine type 2 receptor (CCR4) on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038153
term: CCL2-activated CCR4 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of the C-C chemokine CCL2 to a C-C chemokine type 4 receptor (CCR4) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038154
term: interleukin-11-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of interleukin-11 to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038155
term: interleukin-23-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-23 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038156
term: interleukin-3-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-3 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038157
term: granulocyte-macrophage colony-stimulating factor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of the cytokine granulocyte macrophage colony-stimulating factor (GM-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. GM-CSF binds to a heterodimer receptor (CSF2R) consisting of an alpha ligand-binding subunit, and a common beta subunit that is shared with other cytokine receptors.


go_id: GO:0038158
term: granulocyte colony-stimulating factor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of the cytokine granulocyte colony-stimulating factor (G-CSF) to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. G-CSF binds to the receptor (CSF3R).


go_id: GO:0038159
term: C-X-C chemokine receptor CXCR4 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a the C-X-C chemokine type 4 receptor on the surface of a cell binding to one of it's physiological ligands, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038160
term: CXCL12-activated CXCR4 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of the C-X-C chemokine CXCL12 to a C-X-C chemokine type 4 receptor (CXCR4) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038161
term: prolactin signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of the peptide hormone prolactin to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038162
term: erythropoietin-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by erythropoietin (EPO) binding to the erythropoietin receptor (EPO-R) on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038163
term: thrombopoietin-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by thrombopoietin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038164
term: thrombopoietin receptor activity
ontology: MF
definition:
Combining with the glycoprotein thrombopoietin and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0038165
term: oncostatin-M-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by oncostatin-M (OSM) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. OSM can signal via at least two different receptors (a specific receptor and a LIF receptor) to activate different downstream signal transduction pathways.


go_id: GO:0038166
term: angiotensin-activated signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway initiated by angiotensin II binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038167
ontology: BP
term:
epidermal growth factor receptor signaling pathway via positive regulation of NF-kappaB transcription factor activity

definition:
An epidermal growth factor receptor signaling pathway in which the signal transmitted via the activation of the transcription factor NF-kappaB.


go_id: GO:0038168
term: epidermal growth factor receptor signaling pathway via I-kappaB kinase/NF-kappaB cascade
ontology: BP
definition:
An epidermal growth factor receptor signaling pathway in which the signal transmitted via I-kappaB-kinase (IKK)-dependent activation of the transcription factor NF-kappaB.


go_id: GO:0038169
term: somatostatin receptor signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway initiated by somatostatin binding to the somatostatin receptor (SSTR) on the surface of a target cell, and ending with the regulation of a downstream cellular process.


go_id: GO:0038170
term: somatostatin signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway initiated by somatostatin binding to a somatostatin receptor (SSTR), and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038171
term: cannabinoid signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway initiated by a cannabinoid binding to its receptor on the cell surface, and ending with the regulation of a downstream cellular process, e.g. transcription. Cannabinoids are a class of diverse chemical compounds that include the endocannabinoids and the phytocannabinoids.


go_id: GO:0038172
term: interleukin-33-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-33 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038173
term: interleukin-17A-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-17A binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038174
term: interleukin-17A receptor activity
ontology: MF
definition:
Combining with the cytokine interleukin-17A and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0038175
term: negative regulation of SREBP signaling pathway in response to increased oxygen levels
ontology: BP
definition:
Any process that stops, prevents or reduces the frequency, rate or extent of the SREBP signaling pathway in response to an increase in oxygen levels.


go_id: GO:0038176
term: positive regulation of SREBP signaling pathway in response to decreased oxygen levels
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the SREBP signaling pathway in response to a decrease in oxygen levels.


go_id: GO:0038177
term: death receptor agonist activity
ontology: MF
definition:
Interacting with a death receptor such that the proportion of death receptors in an active form is increased. Ligand binding to a death receptor often induces a conformational change to activate the receptor.


go_id: GO:0038178
term: complement component C5a signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway initiated by a C5a component of the complement pathway binding to a complement receptor, and ending with regulation of a downstream cellular process. C5a is a peptide derived from the C5 complement factor.


go_id: GO:0038179
term: neurotrophin signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by neurotrophin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Neurotrophins are a family of secreted growth factors that induce the survival, development, and function of neurons.


go_id: GO:0038180
term: nerve growth factor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by nerve growth factor (NGF) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038181
term: bile acid receptor activity
ontology: MF
definition:
Combining with a bile acid and transmitting the signal to initiate a change in cell activity. A bile acid is any member of a group of steroid carboxylic acids occurring in bile.


go_id: GO:0038182
term: G protein-coupled bile acid receptor activity
ontology: MF
definition:
Combining with an extracellular bile acid and transmitting the signal across the membrane by activating an associated G-protein; promotes the exchange of GDP for GTP on the alpha subunit of a heterotrimeric G-protein complex.


go_id: GO:0038183
term: bile acid signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by bile acid binding to its receptor, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038184
term: cell surface bile acid receptor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by binding of a bile acid to a receptor on the surface of a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038185
term: intracellular bile acid receptor signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by a bile acid binding to an receptor located within a cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038187
term: pattern recognition receptor activity
ontology: MF
definition:
Combining with a pathogen-associated molecular pattern (PAMP), a structure conserved among microbial species to initiate an innate immune response.


go_id: GO:0038188
term: cholecystokinin signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway initiated by cholecystokinin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038189
term: neuropilin signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by an extracellular ligand binding to a neuropilin protein on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038190
term: VEGF-activated neuropilin signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by vascular endothelial growth factor (VEGF) binding to a neuropilin protein on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038192
term: gastric inhibitory peptide signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway initiated by gastric inhibitory peptide (GIP) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038193
term: thromboxane A2 signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway initiated by thromboxane A2 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038194
term: thyroid-stimulating hormone signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway initiated by thyroid-stimulating hormone (thyrotropin) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038195
term: urokinase plasminogen activator signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by urokinase plasminogen activator binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0038196
term: type III interferon signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by type III interferon binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription. Interferon lambda is the only member of the type III interferon found so far.


go_id: GO:0038197
term: type I interferon receptor complex
ontology: CC
definition:
A heterodimeric protein complex that binds a type I interferon and transmits the signal across the membrane into the cell. Consists of an alpha subunit (IFNAR1) and a beta subunit (IFNAR2).


go_id: GO:0038198
term: auxin receptor activity
ontology: MF
definition:
Combining with auxin and transmitting the signal in the cell to initiate a change in cell activity. Auxin is a plant hormone (phytohormone).


go_id: GO:0038199
term: ethylene receptor activity
ontology: MF
definition:
Combining with ethylene and transmitting the signal in the cell to initiate a change in cell activity.


go_id: GO:0038200
term: ethylene receptor histidine kinase activity
ontology: MF
definition:
Combining with ethylene and transmitting the signal within the cell to initiate a change in cell activity by catalysis of the reaction: ATP + a protein-L-histidine = ADP + a protein-L-histidine phosphate.


go_id: GO:0038201
term: TOR complex
ontology: CC
definition:
A protein complex that contains at least TOR (target of rapamycin) in complex with other signaling components. Mediates the phosphorylation and activation of downstream signaling components including PKB (AKT) or S6K.


go_id: GO:0038202
term: TORC1 signaling
ontology: BP
definition:
A series of intracellular molecular signals mediated by TORC1; TOR (target of rapamycin) in complex with at least Raptor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.


go_id: GO:0038203
term: TORC2 signaling
ontology: BP
definition:
A series of intracellular molecular signals mediated by TORC2; TOR (rapamycin-insensitive companion of TOR) in complex with at least Rictor (regulatory-associated protein of TOR), or orthologs of, and other signaling components.


go_id: GO:0039003
term: pronephric field specification
ontology: BP
definition:
The process in which regions of the embryo are delineated into the area in which the pronephric kidney will develop.


go_id: GO:0039005
term: specification of pronephric tubule identity
ontology: BP
definition:
The process in which the tubules arranged along the proximal/distal axis of the pronephric nephron acquire their identity.


go_id: GO:0039006
term: pronephric nephron tubule formation
ontology: BP
definition:
The developmental process pertaining to the initial formation of a pronephric nephron tubule from unspecified parts. A pronephric nephron tubule is an epithelial tube that is part of a nephron in the pronephros.


go_id: GO:0039007
term: pronephric nephron morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the pronephric nephron are generated and organized. A pronephric nephron is the functional unit of the pronephros.


go_id: GO:0039008
term: pronephric nephron tubule morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of a pronephric nephron tubule are generated and organized from an epithelium. A pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron.


go_id: GO:0039009
term: rectal diverticulum development
ontology: BP
definition:
The process whose specific outcome is the progression of the rectal diverticulum over time, from its formation to the mature structure. The rectal diverticulum is an outgrowth of the cloaca and links the pronephric kidney to the exterior.


go_id: GO:0039011
term: pronephric proximal tubule morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of a pronephric nephron proximal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.


go_id: GO:0039012
term: pronephric sinus development
ontology: BP
definition:
The process whose specific outcome is the progression of the pronephric sinus over time, from its formation to the mature structure. The pronephric sinus is an ill-defined capillary network that lies between the pronephric tubules.


go_id: GO:0039013
term: pronephric distal tubule morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of a pronephric nephron distal tubule are generated and organized. A pronephric nephron tubule is an epithelial tube that is part of the pronephros.


go_id: GO:0039014
term: cell differentiation involved in pronephros development
ontology: BP
definition:
The process in which relatively unspecialized cells acquire specialized structural and/or functional features that characterize the cells of the pronephros as it progresses from its formation to the mature state.


go_id: GO:0039015
term: cell proliferation involved in pronephros development
ontology: BP
definition:
The multiplication or reproduction of cells, resulting in the expansion of the population in the pronephros.


go_id: GO:0039016
term: cell-cell signaling involved in pronephros development
ontology: BP
definition:
Any process that mediates the transfer of information from one cell to another and contributes to the progression of the pronephros over time, from its formation to the mature organ.


go_id: GO:0039017
term: pattern specification involved in pronephros development
ontology: BP
definition:
Any developmental process that results in the creation of defined areas or spaces within the pronephros to which cells respond and eventually are instructed to differentiate.


go_id: GO:0039018
term: nephrostome development
ontology: BP
definition:
The process whose specific outcome is the progression of the nephrostome over time, from its formation to the mature structure. The nephrostome is the opening of the pronephros into the body cavity.


go_id: GO:0039019
term: pronephric nephron development
ontology: BP
definition:
The process whose specific outcome is the progression of the pronephric nephron over time, from its formation to the mature structure. A pronephric nephron is the functional unit of the pronephros.


go_id: GO:0039020
term: pronephric nephron tubule development
ontology: BP
definition:
The process whose specific outcome is the progression of a pronephric nephron tubule over time, from its formation to the mature structure. The pronephric nephron tubule is an epithelial tube that is part of the pronephric nephron and connects the filtration unit (glomerulus or glomus) of the pronephros to the pronephric duct.


go_id: GO:0039021
term: pronephric glomerulus development
ontology: BP
definition:
The progression of the glomerulus of the pronephric kidney over time from its initial formation until its mature state. The pronephric glomerulus is part of the pronephric nephron and is restricted to one body segment.


go_id: GO:0039022
term: pronephric duct development
ontology: BP
definition:
The process whose specific outcome is the progression of the pronephric duct over time, from its formation to the mature structure. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the pronephric kidney.


go_id: GO:0039023
term: pronephric duct morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the pronephric duct are generated and organized. The pronephric duct collects the filtrate from the pronephric tubules and opens to the exterior of the kidney.


go_id: GO:0039501
term: suppression by virus of host type I interferon production
ontology: BP
definition:
Any viral process that results in the inhibition of host cell type I interferon production. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


go_id: GO:0039502
term: suppression by virus of host type I interferon-mediated signaling pathway
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of type I interferon-mediated signaling in the host organism. Type I interferons include the interferon-alpha, beta, delta, episilon, zeta, kappa, tau, and omega gene families.


go_id: GO:0039503
term: suppression by virus of host innate immune response
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the innate immune response of the host organism, the host's first line of defense.


go_id: GO:0039504
term: suppression by virus of host adaptive immune response
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the adaptive immune response of the host organism, an immune response based on directed amplification of specific receptors for antigen produced through a somatic diversification process, and allowing for enhanced response to subsequent exposures to the same antigen (immunological memory).


go_id: GO:0039505
ontology: BP
term:
suppression by virus of host antigen processing and presentation of peptide antigen via MHC class II

definition:
Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC class II protein complex.


go_id: GO:0039506
term: modulation by virus of host molecular function
ontology: BP
definition:
The process in which a virus effects a change in the function of a host protein via a direct interaction.


go_id: GO:0039507
term: suppression by virus of host molecular function
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host protein.


go_id: GO:0039508
term: suppression by virus of host receptor activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host receptor.


go_id: GO:0039509
term: suppression by virus of host pattern recognition receptor activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host pattern recognition receptor. A pattern recognition receptor combines with a molecular pattern based on a repeating or polymeric structure, such as a polysaccharide or peptidoglycan, to initiate a change in cell activity.


go_id: GO:0039511
term: suppression by virus of host interferon receptor activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the functional activity of a host interferon receptor.


go_id: GO:0039512
term: suppression by virus of host protein tyrosine kinase activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein tyrosine kinase activity.


go_id: GO:0039513
term: suppression by virus of host catalytic activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host enzyme activity.


go_id: GO:0039514
term: suppression by virus of host JAK-STAT cascade
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the JAK-STAT signal cascade in the host organism.


go_id: GO:0039517
term: modulation by virus of host protein serine/threonine phosphatase activity
ontology: BP
definition:
The process in which a virus effects a change in host protein serine/threonine phosphatase activity.


go_id: GO:0039518
term: suppression by virus of host cytokine activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host cytokine activity.


go_id: GO:0039519
term: modulation by virus of host autophagy
ontology: BP
definition:
Any process in which a virus effect a change in the frequency, rate or extent of autophagy in the host.


go_id: GO:0039520
term: induction by virus of host autophagy
ontology: BP
definition:
Any process in which a virus activates or increases the frequency, rate or extent of autophagy in the host.


go_id: GO:0039521
term: suppression by virus of host autophagy
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of autophagy in the host.


go_id: GO:0039522
term: suppression by virus of host mRNA export from nucleus
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of movement of mRNA from the nucleus to the cytoplasm in the host organism.


go_id: GO:0039523
term: suppression by virus of host mRNA transcription via inhibition of RNA polymerase II activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host mRNA transcription by directly inhibiting RNA polymerase II activity.


go_id: GO:0039524
term: suppression by virus of host mRNA processing
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of mRNA processing in the host cell. mRNA processing is the conversion of a primary mRNA transcript into one or more mature mRNA(s) prior to translation into polypeptide.


go_id: GO:0039526
term: modulation by virus of host apoptotic process
ontology: BP
definition:
Any process in which a virus modulates the frequency, rate or extent of apoptosis of infected host cells.


go_id: GO:0039527
term: suppression by virus of host TRAF-mediated signal transduction
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of TRAF-mediated signal transduction in the host.


go_id: GO:0039528
term: cytoplasmic pattern recognition receptor signaling pathway in response to virus
ontology: BP
definition:
The series of molecular signals initiated by the binding of a virus or viral RNA binding to a pattern recognition receptor (PRR) located in the cytoplasm. Cytosolic PRRs such as RIG-I (DDX58) and MDA-5 (IFIH1) detect RNA synthesized during active viral replication and trigger a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.


go_id: GO:0039529
term: RIG-I signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by the binding of viral RNA to a pattern recognition receptor (PRR) RIG-1 (also known as DDX58). RIG-I is a cytoplasmic receptor that detects RNA synthesized during viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.


go_id: GO:0039530
term: MDA-5 signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by viral RNA binding of a cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1). MDA-5 is a cytoplasmic receptor that detects RNA synthesized during viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.


go_id: GO:0039531
term: regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a cytoplasmic pattern recognition receptor signaling pathway in response to a virus.


go_id: GO:0039532
term: negative regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the series of a cytoplasmic pattern recognition receptor signaling pathway in response to a virus.


go_id: GO:0039533
term: regulation of MDA-5 signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the series of molecular signals generated as a consequence of the cytoplasmic pattern recognition receptor (PRR) MDA-5 (also known as IFIH1) binding to viral RNA.


go_id: GO:0039534
term: negative regulation of MDA-5 signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the series of the MDA-5 signaling pathway.


go_id: GO:0039536
term: negative regulation of RIG-I signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of the RIG-I signaling pathway.


go_id: GO:0039537
ontology: BP
term:
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway

definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the host viral-induced cytoplasmic pattern recognition receptor signaling pathway. This is a mechanism by which the virus evades the host innate immune response.


go_id: GO:0039540
ontology: BP
term:
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host RIG-I activity

definition:
Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of RIG-1 (also known as DDX58). The cytoplasmic pattern recognition RIG-I recognizes viral RNA synthesized during active viral replication and signals to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.


go_id: GO:0039545
ontology: BP
term:
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of MAVS activity

definition:
Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host MAVS (mitochondrial antiviral signaling protein). MAVS is a signal transducer that lies downstream of the viral RNA receptors MDA-5 and RIG-I to coordinate host innate immune responses.


go_id: GO:0039547
term: suppression by virus of host TRAF activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the activity of a host TRAF (tumor necrosis factor receptor-associated factor) protein. TRAFs are intracellular signal transducers that lie downstream of receptors including RIG-I, MDA-5 and Toll-like receptors (TLR) and transfer the signal to other intracellular signaling components.


go_id: GO:0039548
ontology: BP
term:
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF3 activity

definition:
Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of host IRF3 (interferon regulatory factor-3). IRF3 is a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF3, which allows IRF3 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.


go_id: GO:0039552
term: RIG-I binding
ontology: MF
definition:
Binding to RIG-I, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral RNA.


go_id: GO:0039553
term: suppression by virus of host chemokine activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host chemokine activity.


go_id: GO:0039554
ontology: BP
term:
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of host MDA-5 activity

definition:
Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by inhibiting the activity of MDA-5 (also known as IFIH1). The cytoplasmic pattern recognition receptor MDA-5 detects dsRNA synthesized during active viral replication and triggers a signaling pathway to protect the host against viral infection, for example by inducing the expression of antiviral cytokines.


go_id: GO:0039556
term: MDA-5 binding
ontology: MF
definition:
Binding to MDA-5, a cytosolic pattern recognition receptor that initiates an antiviral signaling pathway upon binding to viral dsRNA.


go_id: GO:0039557
ontology: BP
term:
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IRF7 activity

definition:
Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of IRF7 (interferon regulatory factor-7). IRF7 a transcription factor in the RIG-I/MDA-5 signaling pathway. Viral infection triggers phosphorylation of cytoplasmic IRF7, which allows IRF7 to form a homodimer, migrate to the nucleus, and activate transcription of IFN-alpha and IFN-beta genes.


go_id: GO:0039560
term: suppression by virus of host JAK-STAT cascade via inhibition of host IRF9 activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces a JAK1-STAT signaling cascade in a host organism by reducing the activity of host IRF9 (interferon regulatory factor-9), a transcription factor involved in the innate immune response. Viral infection triggers binding of IRF9 to phosphorylated STAT1 and STAT2, forming the ISGF3 complex. The ISGF3 complex migrates to the nucleus and activates transcription of IFN-responsive genes.


go_id: GO:0039562
term: suppression by virus of host JAK-STAT cascade via inhibition of STAT activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT (signal transducer and activator of transcription). STATs are SH2 domain-containing proteins which lie downstream of many signaling receptors. Upon phosphorylation by JAKs, STAT proteins hetero- or homo-dimerize and translocate to the nucleus to activate transcription of target genes.


go_id: GO:0039563
term: suppression by virus of host JAK-STAT cascade via inhibition of STAT1 activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT1 (signal transducer and activator of transcription 1).


go_id: GO:0039564
term: suppression by virus of host JAK-STAT cascade via inhibition of STAT2 activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host STAT2 (signal transducer and activator of transcription 2).


go_id: GO:0039573
term: suppression by virus of host complement activation
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of complement activation. The activation of complement involves the sequential proteolysis of proteins to generate enzymes with catalytic activities. The biological functions of the complement include opsonization, inflammation, lysis of immune complexes, or enhancement of the humoral immune response. For example, the virus complement control protein (VCP) of vaccinia virus, and the complement control protein of herpesvirus inhibit C3 convertase.


go_id: GO:0039574
term: suppression by virus of host JAK-STAT cascade via inhibition of host TYK2 activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK1-STAT signaling cascade in a host organism by reducing the activity of host TYK2 (tyrosine kinase 2). TYK2 is an intracellular signal-transducing tyrosine kinase that associates with the cytoplasmic tails of cytokine receptors and transmits the cytokine signal by phosphorylating receptor subunits.


go_id: GO:0039576
term: suppression by virus of host JAK-STAT cascade via inhibition of JAK1 activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of a JAK-STAT signal cascade in a host organism by reducing the activity of host JAK1 (Janus Kinase 1).


go_id: GO:0039579
term: suppression by virus of host ISG15-protein conjugation
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host ubiquitin-like protein ISG15 conjugation to a susbtrate. ISG15 is a ubiquitin-like protein that is conjugated to lysine residues on various target proteins. Viruses escape from the antiviral activity of ISG15 by using different mechanisms; the influenza B virus NS1 protein for instance blocks the covalent linkage of ISG15 to its target proteins by directly interacting with ISG15. The papain-like protease from the coronavirus cleaves ISG15 derivatives.


go_id: GO:0039580
term: suppression by virus of host PKR signaling
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host PKR (Protein Kinase regulated by RNA) signaling. Host PKR signaling includes targets such as the translation initiation factor eIF2alpha,  inhibiting protein synthesis as an antiviral response.


go_id: GO:0039584
term: suppression by virus of host protein kinase activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host protein kinase activity.


go_id: GO:0039585
term: PKR-mediated signaling
ontology: BP
definition:
A series of reactions in which a signal is passed on to downstream proteins within the cell via PKR (also known as EIF2AK3), an intracellular protein kinase that is activated by stress signals or upon binding to double-stranded RNA (dsRNA), followed by autophosphorylation. PKR plays a role in the antiviral response, phosphorylating proteins such as the translation initiation factor eIF2 to inhibit protein synthesis during viral infection. Begins with activation of PKR activity, and ends with regulation of a downstream cellular process, e.g. regulation of transcription or inhibition of translation.


go_id: GO:0039586
term: modulation by virus of host PP1 activity
ontology: BP
definition:
The process in which a virus effects a change in host protein phosphatase-1 (PP1) activity, a serine/threonine phosphatase. Different viruses modulate host PP1 activity to remove phosphates from various cellular substrates and downregulate the host's antiviral response.


go_id: GO:0039587
term: suppression by virus of host tetherin activity
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the activity of host tetherin activity. Tetherin (also known as BST2) is an alpha interferon-inducible cellular factor that impairs the release of many enveloped viruses. By blocking tetherin activity, many viruses circumvent its antiviral effects.


go_id: GO:0039588
term: suppression by virus of host antigen processing and presentation
ontology: BP
definition:
Any viral process that inhibits a host antigen-presenting cell expressing a peptide antigen on its cell surface in association with an MHC protein complex.


go_id: GO:0039592
term: suppression by virus of G2/M transition of host mitotic cell cycle
ontology: BP
definition:
Any viral process that decreases the rate or extent of progression from G2 phase to M phase of the host mitotic cell cycle.


go_id: GO:0039593
term: suppression by virus of host exit from mitosis
ontology: BP
definition:
Any viral process which decreases the rate or extent of a host cell leaving M phase of the cell cycle. M phase is the part of the mitotic cell cycle during which mitosis and cytokinesis take place.


go_id: GO:0039595
term: induction by virus of catabolism of host mRNA
ontology: BP
definition:
The process in which a virus increases the frequency, rate or extent of the breakdown of host messenger RNA (mRNA).


go_id: GO:0039596
term: modulation by virus of host protein dephosphorylation
ontology: BP
definition:
Any viral process that modulates the frequency, rate or extent of dephosphorylation of a host protein.


go_id: GO:0039602
term: suppression by virus of host transcription initiation from RNA polymerase II promoter
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of the assembly of the RNA polymerase II preinitiation complex (PIC) at an RNA polymerase II promoter region of a host DNA template.


go_id: GO:0039604
term: suppression by virus of host translation
ontology: BP
definition:
Any process in which a virus prevents or reduces the frequency, rate or extent of translation of host mRNA, for example by cleavage of the host mRNAs.


go_id: GO:0039606
term: suppression by virus of host translation initiation
ontology: BP
definition:
Any process in which a virus prevents or reduces the frequency, rate or extent of host translation initiation, the host process preceding formation of the peptide bond between the first two amino acids of a protein.


go_id: GO:0039611
term: suppression by virus of host translation initiation factor activity
ontology: BP
definition:
Any process in which a virus prevents or reduces the frequency, rate or extent of activity of a host translation initiation factor.


go_id: GO:0039612
term: modulation by virus of host protein phosphorylation
ontology: BP
definition:
Any viral process that modulates the frequency, rate or extent of phosphorylation of viral or host proteins in a host.


go_id: GO:0039613
term: suppression by virus of host protein phosphorylation
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of phosphorylation of viral or host proteins in a host.


go_id: GO:0039614
term: induction by virus of host protein phosphorylation
ontology: BP
definition:
Any process in which a virus activates or increases the frequency, rate or extent of phosphorylation of viral or host proteins in a host.


go_id: GO:0039615
term: T=1 icosahedral viral capsid
ontology: CC
definition:
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=1 symmetry. The T=1 capsid is composed of 12 pentameric capsomeres.


go_id: GO:0039616
term: T=2 icosahedral viral capsid
ontology: CC
definition:
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=2 symmetry. The T=2 capsid is composed of 12 pentameric dimers.


go_id: GO:0039617
term: T=3 icosahedral viral capsid
ontology: CC
definition:
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=3 symmetry. The T=3 capsid is composed of 12 pentameric and 20 hexameric capsomeres.


go_id: GO:0039618
term: T=pseudo3 icosahedral viral capsid
ontology: CC
definition:
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with pseudo T=3 symmetry. The T=pseudo3 capsid is composed of 12 pentameric and 20 hexameric capsomeres.


go_id: GO:0039619
term: T=4 icosahedral viral capsid
ontology: CC
definition:
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=4 symmetry. The T=4 capsid is composed of 12 pentameric and 30 hexameric capsomeres.


go_id: GO:0039620
term: T=7 icosahedral viral capsid
ontology: CC
definition:
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=7 symmetry. The T=7 capsid is composed of 12 pentameric and 60 hexameric capsomeres.


go_id: GO:0039621
term: T=13 icosahedral viral capsid
ontology: CC
definition:
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=13 symmetry. The T=13 capsid is composed of 12 pentameric and 120 hexameric capsomeres.


go_id: GO:0039622
term: T=16 icosahedral viral capsid
ontology: CC
definition:
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=16 symmetry. The T=16 capsid is composed of 12 pentameric and 150 hexameric capsomeres.


go_id: GO:0039623
term: T=25 icosahedral viral capsid
ontology: CC
definition:
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=25 symmetry. The T=25 capsid is composed of 12 pentameric and 240 hexameric capsomeres.


go_id: GO:0039624
term: viral outer capsid
ontology: CC
definition:
The outer layer of a double or triple concentric icosahedral capsid. Outer capsids are part of reoviridae and cystoviridae virions.


go_id: GO:0039625
term: viral inner capsid
ontology: CC
definition:
The inner layer of a double or triple concentric icosahedral capsid. Inner capsids are part of reoviridae and cystoviridae virions.


go_id: GO:0039626
term: viral intermediate capsid
ontology: CC
definition:
The intermediate layer of a triple concentric icosahedral capsid. Intermediate capsids are part of reoviridae virions.


go_id: GO:0039627
term: T=147 icosahedral capsid
ontology: CC
definition:
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=147 symmetry. T=147 icosahedral capsid is composed of 12 pentameric and 1460 hexameric capsomeres for a total of 8820 capsid proteins.


go_id: GO:0039628
term: T=169 icosahedral viral capsid
ontology: CC
definition:
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=169 symmetry. T=169 icosahedral capsid is composed of 12 pentameric and 1680 hexameric capsomeres for a total of 10140 capsid proteins.


go_id: GO:0039629
term: T=219 icosahedral capsid
ontology: CC
definition:
The protein coat that surrounds the infective nucleic acid in some virus particles where the subunits (capsomeres) are arranged to form an icosahedron with T=219 symmetry. T=219 icosahedral capsid is composed of 12 pentameric and 2180 hexameric capsomeres for a total of 13140 capsid proteins.


go_id: GO:0039631
term: DNA translocase activity involved in viral DNA genome packaging
ontology: MF
definition:
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded DNA molecule, that contributes to the packing of viral DNA into a capsid.


go_id: GO:0039632
term: RNA translocase activity involved in viral RNA genome packaging
ontology: MF
definition:
Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive movement along a single- or double-stranded RNA molecule, which contributes to the packaging of viral RNA into a nucleocapsid.


go_id: GO:0039634
term: killing by virus of host cell during superinfection exclusion
ontology: BP
definition:
The viral-killing of a host cell by a pre-existing virus in response to a subsequent infection of the host cell by second virus.


go_id: GO:0039635
term: suppression by virus of host peptidoglycan biosynthetic process
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls.


go_id: GO:0039636
term: suppression by virus of host cell wall biogenesis
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of cell wall biogenesis in the host organism. Cell wall biogenesis includes the biosynthesis of constituent macromolecules, and the assembly and arrangement of these constituent parts.


go_id: GO:0039638
term: lipopolysaccharide-mediated virion attachment to host cell
ontology: BP
definition:
The process by which a virion attaches to a host cell by binding to a lipopolysaccharide (LPS) on the host cell surface.


go_id: GO:0039639
term: suppression by virus of host cell lysis in response to superinfection
ontology: BP
definition:
The prevention or delay of host cell lysis by a pre-existing virus in response to a subsequent infection of the host cell by second virus.


go_id: GO:0039640
term: viral release by cytolysis via suppression of host peptidoglycan biosynthetic process
ontology: BP
definition:
The killing by a virus of host cell by cytolysis, caused by a virus stopping, preventing, or reducing peptidoglycan biosynthesis in the host organism. Peptidoglycans are any of a class of glycoconjugates found in bacterial cell walls.


go_id: GO:0039645
term: modulation by virus of host G1/S transition checkpoint
ontology: BP
definition:
Any viral process that modulates the frequency, rate or extent of the host cell G1/S transition checkpoint.


go_id: GO:0039646
term: modulation by virus of host G0/G1 transition checkpoint
ontology: BP
definition:
Any viral process that modulates the frequency, rate or extent of the host cell G0/G1 transition checkpoint.


go_id: GO:0039648
term: modulation by virus of host protein ubiquitination
ontology: BP
definition:
Any process in which a virus modulates the frequency, rate or extent of protein ubiquitination in the host organism. Ubiquitination is the process in which one or more ubiquitin groups are added to a protein.


go_id: GO:0039649
term: modulation by virus of host ubiquitin-protein ligase activity
ontology: BP
definition:
The process in which a virus effects a change in host ubiquitin-protein ligase activity. Ubiquitin-protein ligase activity catalyzes the reaction: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine.


go_id: GO:0039650
term: suppression by virus of host cysteine-type endopeptidase activity involved in apoptotic process
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of host caspase activity. Caspases are cysteine-type endopeptidases which contribute to the apoptotic process.


go_id: GO:0039651
term: induction by virus of host cysteine-type endopeptidase activity involved in apoptotic process
ontology: BP
definition:
Any process in which a virus increases the frequency, rate or extent of host cysteine-type endopeptidase activity (also called caspase activity) which contributes to the apoptotic process.


go_id: GO:0039653
term: suppression by virus of host transcription
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the activity of host DNA-dependent transcription; the cellular synthesis of RNA on a template of DNA. Viral proteins can interfere with either host RNA polymerase or with transcription factors.


go_id: GO:0039654
term: fusion of virus membrane with host endosome membrane
ontology: BP
definition:
Fusion of a virus membrane with a host endosome membrane. Occurs after internalization of the virus through the endosomal pathway, and results in release of the virus contents into the cell.


go_id: GO:0039656
term: modulation by virus of host gene expression
ontology: BP
definition:
The process in which a virus effects a change in gene expression in its host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.


go_id: GO:0039657
term: suppression by virus of host gene expression
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of gene expression in the host organism. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product or products (proteins or RNA). This includes the production of an RNA transcript as well as any processing to produce a mature RNA product or an mRNA (for protein-coding genes) and the translation of that mRNA into protein. Some protein processing events may be included when they are required to form an active form of a product from an inactive precursor form.


go_id: GO:0039658
term: TBK1-IKKE-DDX3 complex
ontology: CC
definition:
A protein complex containing TBK1 (TANK-binding kinase 1), IKBKE (I-Kappa-B kinase epsilon/IKKE/IKK-epsilon) and the DEAD box family RNA helicase DDX3.


go_id: GO:0039661
term: host organelle outer membrane
ontology: CC
definition:
The outer, i.e. cytoplasm-facing in a cellular organelle, lipid bilayer of an organelle envelope, occurring in a host cell.


go_id: GO:0039663
term: membrane fusion involved in viral entry into host cell
ontology: BP
definition:
Merging of the virion membrane and a host membrane (host plasma membrane or host organelle membrane) that is involved in the uptake of a virus into a host cell.


go_id: GO:0039664
term: lysis of host organelle involved in viral entry into host cell
ontology: BP
definition:
The viral-induced lysis of an organelle (endosome, lysosome, or caveosome) that is involved in the uptake of a virus into a host cell. Occurs once the virus is within the organelle, and results in transfer of the viral contents from the organelle compartment into the cytoplasm.


go_id: GO:0039665
term: permeabilization of host organelle membrane involved in viral entry into host cell
ontology: BP
definition:
Induction of organellar membrane permeabilization triggered by an interaction between the host membrane and a membrane-penetration protein associated with a viral capsid. Results in release of the virus contents from an organelle into the host cell cytoplasm.


go_id: GO:0039666
term: virion attachment to host cell pilus
ontology: BP
definition:
The process by which a virion attaches to a host cell by binding to a pilus on the host cell surface. Pili are retractile filaments that protrude from gram-negative bacteria. Filamentous viruses can attach to the pilus tip, whereas icosahedral viruses can attach to the pilus side.


go_id: GO:0039667
term: viral entry into host cell via pilus retraction
ontology: BP
definition:
The uptake of a virus or viral genetic material into a host cell which occurs through retraction of a virion-bound pilus.


go_id: GO:0039668
term: viral entry into host cell via pilus basal pore
ontology: BP
definition:
The uptake of a virus or viral genetic material into a host cell which occurs through retraction of the virion-bound pilus, followed by entry of the viral genome into the host cell through the pilus basal pore. Filamentous bacteriophages absorb to the tip of the F-pili and can enter the bacterial cell in this way.


go_id: GO:0039669
term: viral entry into host cell via pilus retraction and membrane fusion
ontology: BP
definition:
The uptake of a virus into a host cell which occurs via retraction of the viral-bound pilus to bring the virus in contact with the host cell membrane, followed by fusion of the bacteriophage membrane with the host outer membrane.


go_id: GO:0039671
term: evasion by virus of host natural killer cell activity
ontology: BP
definition:
Any process by which a virus avoids the effects mediated by the host organism's natural killer (NK) cells.


go_id: GO:0039672
term: suppression by virus of host natural killer cell activation
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of natural killer cell activation in the host.


go_id: GO:0039675
term: exit of virus from host cell nucleus through nuclear pore
ontology: BP
definition:
The directed movement of the viral genome or a viral particle out of the host cell nucleus through the nuclear pore.


go_id: GO:0039677
term: exit of virus from host cell nucleus via nuclear envelope disassembly
ontology: BP
definition:
The directed movement of the viral genome or a viral particle out of the host cell nucleus that involves disruption of the nuclear membrane envelope by the virus.


go_id: GO:0039678
term: viral genome ejection through host cell envelope
ontology: BP
definition:
Ejection by a non-enveloped prokaryotic virus of its genome into the host cytoplasm. Caudovirales carry an ejection apparatus that can be long and contractile, long and noncontractile, or short, and is able to penetrate the host cell envelope to deliver the viral genome into the host cell cytoplasm.


go_id: GO:0039679
term: viral occlusion body
ontology: CC
definition:
A crystalline protein matrix surrounding the nucleocapsids of some insect viruses after their release in the environment. Produced in the host cell, the occlusion body protects the infectious virion after death of the host.


go_id: GO:0039680
term: actin-dependent intracellular transport of virus towards nucleus
ontology: BP
definition:
The directed movement of a virus, or part of a virus, towards the host cell nucleus using actin filaments.


go_id: GO:0039682
term: rolling circle viral DNA replication
ontology: BP
definition:
A process of unidirectional viral DNA replication that takes place on a circular DNA to rapidly produce numerous copies of the viral genome. Involves creating a nick in one strand of the circular DNA molecule at the origin of replication. DNA is then synthesized by DNA polymerase. Using the non-nicked strand as a template, replication proceeds around the circular DNA molecule, displacing the nicked strand as single-stranded DNA.


go_id: GO:0039685
term: rolling hairpin viral DNA replication
ontology: BP
definition:
A viral DNA replication process where a 3' hairpin structure in the viral single-stranded DNA (ssDNA) template serves as a primer for host enzymes to synthesize DNA.


go_id: GO:0039686
term: bidirectional double-stranded viral DNA replication
ontology: BP
definition:
A viral DNA replication process where replication occurs in both directions from the starting point. This creates two replication forks, moving in opposite directions.


go_id: GO:0039687
term: viral DNA strand displacement replication
ontology: BP
definition:
A viral DNA replication process where only one strand is replicated at once, and which releases a single stranded DNA (ssDNA).


go_id: GO:0039688
term: viral double stranded DNA replication via reverse transcription
ontology: BP
definition:
A DNA replication process that uses viral RNA as a template for RNA-dependent DNA polymerases (e.g. reverse transcriptase) that synthesize the new strands.


go_id: GO:0039689
term: negative stranded viral RNA replication
ontology: BP
definition:
A viral genome replication process where the template genome is negative stranded, single stranded RNA ((-)ssRNA).


go_id: GO:0039690
term: positive stranded viral RNA replication
ontology: BP
definition:
A viral genome replication process where the template genome is positive stranded, single stranded RNA ((+)ssRNA). Replication of the positive strand leads to dsRNA formation, which in turn is transcribed into positive single stranded RNA.


go_id: GO:0039691
term: double stranded viral RNA replication
ontology: BP
definition:
A viral genome replication process where the template genome is double stranded RNA (dsRNA). Genomic dsRNA is first transcribed into single-stranded (ss) mRNA, which is then replicated to ds-genomic RNA.


go_id: GO:0039692
term: single stranded viral RNA replication via double stranded DNA intermediate
ontology: BP
definition:
A viral genome replication where the template is single-stranded RNA (ssRNA), and which proceeds via a double stranded DNA (dsDNA) intermediate molecule. Viral genomic RNA is first reverse transcribed into dsDNA, which integrates into the host chromosomal DNA, where it is transcribed by host RNA polymerase II.


go_id: GO:0039697
term: negative stranded viral RNA transcription
ontology: BP
definition:
A viral transcription process that uses negative stranded (-) single stranded (ss) RNA as a template.


go_id: GO:0039698
term: polyadenylation of viral mRNA by polymerase stuttering
ontology: BP
definition:
Polyadenylation of viral mRNA through a polymerase stuttering mechanism. The stop signal present at the end of each gene comprises a stretch of uridine on which the viral polymerase acquires a stuttering behavior: after each adenine inserted, the polymerase moves back one nucleotide along with the mRNA. It resumes transcription adding a new adenine, then again moves back, thereby producing a polyA tail.


go_id: GO:0039699
term: viral mRNA cap methylation
ontology: BP
definition:
An innate immune response evasion mechanism in which a virus methylates the 2'-O-ribose of the first or second transcribed nucleotide of its mRNAs. Methylation allows evasion of the host innate immune response, which degrades cap0 (non-methylated) mRNAs.


go_id: GO:0039700
term: fusion of viral membrane with host outer nuclear membrane
ontology: BP
definition:
Fusion of a viral primary envelope with the host outer nuclear membrane during nuclear egress. The transitory primary envelope is acquired by the virus as it buds at the inner nuclear membrane and gains access to the perinuclear space. This membrane is lost by fusing with the host outer nuclear membrane during nuclear exit.


go_id: GO:0039701
term: microtubule-dependent intracellular transport of viral material towards cell periphery
ontology: BP
definition:
The directed movement of the viral genome or a viral particle towards the cell periphery using host microtubules. Mostly used by viruses that replicate their genome near or in the nucleus to allows newly assembled viral progeny to reach the plasma membrane.


go_id: GO:0039702
term: viral budding via host ESCRT complex
ontology: BP
definition:
Viral budding which uses a host ESCRT protein complex, or complexes, to mediate the budding process.


go_id: GO:0039704
term: viral translational shunt
ontology: BP
definition:
A viral translation initiation mechanism where ribosomes are loaded onto viral mRNA at the 5'-cap structure and start scanning for a short distance before by-passing the large internal leader region and initiating at a downstream start site.


go_id: GO:0039705
term: viral translational readthrough
ontology: BP
definition:
The continuation of translation of a viral mRNA beyond a stop codon by the use of a special tRNA that recognizes the UAG and UGA codons as modified amino acids, rather than as termination codons.


go_id: GO:0039706
term: co-receptor binding
ontology: MF
definition:
Binding to a coreceptor. A coreceptor acts in cooperation with a primary receptor to transmit a signal within the cell.


go_id: GO:0039707
term: pore formation by virus in membrane of host cell
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components by a virus to form a pore complex in a membrane of a host organism.


go_id: GO:0039708
term: nuclear capsid assembly
ontology: BP
definition:
The assembly of a virus capsid that occurs in the nucleus. The assembly of large icosahedral shells for herpesviridae and adenoviridae requires structural proteins that act as chaperones for assembly.


go_id: GO:0039710
term: cytoplasmic icosahedral capsid assembly
ontology: BP
definition:
The assembly of an icosahedral viral capsid in the cytoplasm. Often occurs by assembling around the viral genome.


go_id: GO:0039711
term: cytoplasmic helical capsid assembly
ontology: BP
definition:
The assembly of a helical viral capsid in the cytoplasm. Occurs by assembling around the viral genome.


go_id: GO:0039713
term: viral factory
ontology: CC
definition:
An intracellular compartment in a host cell which increases the efficiency of viral replication, and shields the virus from host defenses. Viral factories can be either cytoplasmic or nuclear and often arise from extensive rearrangement of host cell cytoskeletal and/or cell membrane compartments.


go_id: GO:0039716
term: viroplasm viral factory
ontology: CC
definition:
A cytoplasmic viral factory that is electron dense due to high levels of viral RNA. Produced by nucleo-cytoplasmic large DNA viruses (NCLDV) like Poxviridae, Asfarviridae and Iridoviridae, and dsRNA viruses like Reoviridae.


go_id: GO:0039717
term: spherule viral factory
ontology: CC
definition:
A cytoplasmic viral factory which is a 50-400nm diameter membrane invagination. Spherules can appear on several enveloped cellular components depending on the virus.


go_id: GO:0039718
term: double membrane vesicle viral factory
ontology: CC
definition:
A cytoplasmic viral factory that consists of a double-membrane bound vesicle. Has a diameter of 200-300nm and is derived from the endoplasmic reticulum or Golgi apparatus. Produced by Picornaviridae, Nidovirales, Arteriviridae and Coronaviridae.


go_id: GO:0039719
term: tube viral factory
ontology: CC
definition:
A cytoplasmic viral factory derived from the Golgi in which Bunyaviridae replication takes place. Tubes are membranous structures close to the assembly and budding sites, and their function may be to connect viral replication and morphogenesis inside viral factories.


go_id: GO:0039720
term: virogenic stroma
ontology: CC
definition:
A nuclear viral factory formed by Baculoviruses. A vesicular structure in which virions are assembled.


go_id: GO:0039722
term: suppression by virus of host toll-like receptor signaling pathway
ontology: BP
definition:
Any process in which a virus stops, prevents, or reduces the frequency, rate or extent of toll-like receptor (TLR) signaling in the host organism.


go_id: GO:0039723
ontology: BP
term:
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of TBK1 activity

definition:
Any process in which a virus stops, prevents, or reduces a viral-induced cytoplasmic pattern recognition receptor signaling pathway in a host organism by reducing the activity of a host serine/threonine kinase TBK1.


go_id: GO:0039724
ontology: BP
term:
suppression by virus of host viral-induced cytoplasmic pattern recognition receptor signaling pathway via inhibition of IKBKE activity

definition:
Any process in which a virus stops, prevents, or reduces a host viral-induced cytoplasmic pattern recognition receptor signaling pathway by reducing the activity of host I-kappa-B kinase epsilon (IKBKE/IKK-epsilon/IKK-E).


go_id: GO:0040001
term: establishment of mitotic spindle localization
ontology: BP
definition:
The cell cycle process in which the directed movement of the mitotic spindle to a specific location in the cell occurs.


go_id: GO:0040002
term: collagen and cuticulin-based cuticle development
ontology: BP
definition:
Synthesis and deposition of a collagen and cuticulin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Caenorhabditis elegans.


go_id: GO:0040003
term: chitin-based cuticle development
ontology: BP
definition:
Synthesis and deposition of a chitin-based noncellular, hardened, or membranous secretion from an epithelial sheet. An example of this process is found in Drosophila melanogaster.


go_id: GO:0040004
term: collagen and cuticulin-based cuticle attachment to epithelium
ontology: BP
definition:
Attaching of a collagen and cuticulin-based cuticle to the epithelium underlying it. An example of this process is found in Caenorhabditis elegans.


go_id: GO:0040005
term: chitin-based cuticle attachment to epithelium
ontology: BP
definition:
Attaching of a chitin-containing cuticle to the epithelium underlying it. An example of this process is found in Drosophila melanogaster.


go_id: GO:0040008
term: regulation of growth
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the growth of all or part of an organism so that it occurs at its proper speed, either globally or in a specific part of the organism's development.


go_id: GO:0040013
term: negative regulation of locomotion
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of locomotion of a cell or organism.


go_id: GO:0040014
term: regulation of multicellular organism growth
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of growth of the body of an organism so that it reaches its usual body size.


go_id: GO:0040015
term: negative regulation of multicellular organism growth
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of growth of an organism to reach its usual body size.


go_id: GO:0040017
term: positive regulation of locomotion
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of locomotion of a cell or organism.


go_id: GO:0040018
term: positive regulation of multicellular organism growth
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of growth of an organism to reach its usual body size.


go_id: GO:0040020
term: regulation of meiotic nuclear division
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of meiotic nuclear division, the process in which the nucleus of a diploid cell divides twice forming four haploid cells, one or more of which usually function as gametes.


go_id: GO:0040024
term: dauer larval development
ontology: BP
definition:
The process whose specific outcome is the progression of the dauer larva over time, through the facultative diapause of the dauer (enduring) larval stage, with specialized traits adapted for dispersal and long-term survival, with elevated stress resistance and without feeding.


go_id: GO:0040025
term: vulval development
ontology: BP
definition:
The process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.


go_id: GO:0040026
term: positive regulation of vulval development
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.


go_id: GO:0040027
term: negative regulation of vulval development
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.


go_id: GO:0040028
term: regulation of vulval development
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of development of the vulva. Vulval development is the process whose specific outcome is the progression of the egg-laying organ of female and hermaphrodite nematodes over time, from its formation to the mature structure. In nematodes, the vulva is formed from ventral epidermal cells during larval stages to give rise to a fully formed vulva in the adult.


go_id: GO:0040029
term: epigenetic regulation of gene expression
ontology: BP
definition:
A process that modulates the frequency, rate or extent of gene expression through chromatin remodelling either by modifying higher order chromatin fiber structure, nucleosomal histones, or the DNA. Once established, this regulation may be maintained over many cell divisions. It can also be heritable in the absence of the instigating signal.


go_id: GO:0040031
term: snRNA modification
ontology: BP
definition:
The covalent alteration of one or more nucleotides within snRNA, resulting in a change in the properties of the snRNA.


go_id: GO:0040032
term: post-embryonic body morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the post-embryonic soma are generated and organized.


go_id: GO:0040033
term: sRNA-mediated gene silencing
ontology: BP
definition:
A post-transcriptional gene silencing pathway mediated by the action of small regulatory non-coding RNAs (sRNAs). sRNAs are 20-500 nucleotides in length and found in bacteria.


go_id: GO:0040034
term: regulation of development, heterochronic
ontology: BP
definition:
Any process that modulates the consistent predetermined time point at which an integrated living unit or organism progresses from an initial condition to a later condition and the rate at which this time point is reached.


go_id: GO:0040035
term: hermaphrodite genitalia development
ontology: BP
definition:
The process whose specific outcome is the progression of the hermaphrodite genitalia over time, from formation to the mature structures.


go_id: GO:0040036
term: regulation of fibroblast growth factor receptor signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.


go_id: GO:0040037
term: negative regulation of fibroblast growth factor receptor signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of fibroblast growth factor receptor signaling pathway activity.


go_id: GO:0040038
term: polar body extrusion after meiotic divisions
ontology: BP
definition:
The cell cycle process in which two small cells are generated, as byproducts destined to degenerate, as a result of the first and second meiotic divisions of a primary oocyte during its development to a mature ovum. One polar body is formed in the first division of meiosis and the other in the second division; at each division, the cytoplasm divides unequally, so that the polar body is of much smaller size than the developing oocyte. At the second division in which a polar body is formed, the polar body and the developing oocyte each contain a haploid set of chromosomes.


go_id: GO:0040039
term: inductive cell migration
ontology: BP
definition:
Migration of a cell in a multicellular organism that, having changed its location, is required to induce normal properties in one or more cells at its new location. An example of this would be the distal tip cells of Caenorhabditis elegans.


go_id: GO:0042000
term: translocation of peptides or proteins into host
ontology: BP
definition:
The directed movement of peptides or proteins produced by an organism to a location inside its host organism. The host is defined as the larger of the organisms involved in a symbiotic interaction.


go_id: GO:0042001
term: hermaphrodite somatic sex determination
ontology: BP
definition:
The determination of sex and sexual phenotypes in a hermaphroditic organism's soma. An example of this is found in Caenorhabditis elegans.


go_id: GO:0042003
term: masculinization of hermaphrodite soma
ontology: BP
definition:
Promotion of male sex and sexual phenotypes in the hermaphroditic nematode soma. An example of this is found in Caenorhabditis elegans.


go_id: GO:0042004
term: feminization of hermaphrodite soma
ontology: BP
definition:
Promotion of female sex and sexual phenotypes in the hermaphroditic soma. An example of this is found in Caenorhabditis elegans.


go_id: GO:0042006
term: masculinization of hermaphroditic germ-line
ontology: BP
definition:
The determination of male sex and sexual phenotype in the germ-line of the hermaphrodite. An example of this is found in Caenorhabditis elegans.


go_id: GO:0042008
term: interleukin-18 receptor activity
ontology: MF
definition:
Combining with interleukin-18 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0042010
term: interleukin-15 receptor activity
ontology: MF
definition:
Combining with interleukin-15 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0042012
term: interleukin-16 receptor activity
ontology: MF
definition:
Combining with interleukin-16 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0042014
term: interleukin-19 receptor activity
ontology: MF
definition:
Combining with interleukin-19 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0042016
term: interleukin-20 receptor activity
ontology: MF
definition:
Combining with interleukin-20 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0042018
term: interleukin-22 receptor activity
ontology: MF
definition:
Combining with interleukin-22 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0042020
term: interleukin-23 receptor activity
ontology: MF
definition:
Combining with interleukin-23 and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity.


go_id: GO:0042022
term: interleukin-12 receptor complex
ontology: CC
definition:
A protein complex that binds interleukin-12 and that consists of, at a minimum, a dimeric interleukin and its two receptor subunits as well as optional additional kinase subunits.


go_id: GO:0042023
term: DNA endoreduplication
ontology: BP
definition:
Regulated re-replication of DNA within a single cell cycle, resulting in an increased cell ploidy. An example of this process occurs in the synthesis of Drosophila salivary gland cell polytene chromosomes.


go_id: GO:0042025
term: host cell nucleus
ontology: CC
definition:
A membrane-bounded organelle as it is found in the host cell in which chromosomes are housed and replicated. The host is defined as the larger of the organisms involved in a symbiotic interaction.


go_id: GO:0042026
term: protein refolding
ontology: BP
definition:
The process carried out by a cell that restores the biological activity of an unfolded or misfolded protein, using helper proteins such as chaperones.


go_id: GO:0042037
term: peptidyl-histidine methylation, to form pros-methylhistidine
ontology: BP
definition:
The methylation of peptidyl-L-histidine to form peptidyl-L-3'-methyl-L-histidine (otherwise known as pi-methylhistidine, pros-methylhistidine).


go_id: GO:0042038
term: peptidyl-histidine methylation, to form tele-methylhistidine
ontology: BP
definition:
The methylation of peptidyl-L-histidine to form peptidyl-L-1'-methyl-L-histidine (otherwise known as tau-methylhistidine, tele-methylhistidine).


go_id: GO:0042043
term: neurexin family protein binding
ontology: MF
definition:
Binding to a neurexin, a synaptic cell surface protein related to latrotoxin receptor, laminin and agrin. Neurexins act as cell recognition molecules at nerve terminals.


go_id: GO:0042044
term: fluid transport
ontology: BP
definition:
The directed movement of substances that are in liquid form in normal living conditions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0042046
term: W-molybdopterin cofactor metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands.


go_id: GO:0042047
term: W-molybdopterin cofactor biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of the W-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear tungsten ion (W) coordinated by one or two molybdopterin ligands.


go_id: GO:0042049
term: cellular acyl-CoA homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of acyl-CoA within a cell or between a cell and its external environment.


go_id: GO:0042051
term: compound eye photoreceptor development
ontology: BP
definition:
The process whose specific outcome is the progression of a light-responsive receptor in the compound eye over time, from its formation to the mature structure.


go_id: GO:0042052
term: rhabdomere development
ontology: BP
definition:
The assembly and arrangement of a rhabdomere within a cell. The rhabdomere is the organelle on the apical surface of a photoreceptor cell that contains the visual pigments.


go_id: GO:0042053
term: regulation of dopamine metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving dopamine.


go_id: GO:0042054
term: histone methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + histone = S-adenosyl-L-homocysteine + methyl-histone. Histone methylation generally occurs on either an arginine or lysine residue.


go_id: GO:0042056
term: chemoattractant activity
ontology: MF
definition:
Providing the environmental signal that initiates the directed movement of a motile cell or organism towards a higher concentration of that signal.


go_id: GO:0042058
term: regulation of epidermal growth factor receptor signaling pathway
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.


go_id: GO:0042059
term: negative regulation of epidermal growth factor receptor signaling pathway
ontology: BP
definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of epidermal growth factor receptor signaling pathway activity.


go_id: GO:0042063
term: gliogenesis
ontology: BP
definition:
The process that results in the generation of glial cells. This includes the production of glial progenitors and their differentiation into mature glia.


go_id: GO:0042065
term: glial cell growth
ontology: BP
definition:
Growth of glial cells, non-neuronal cells that provide support and nutrition, maintain homeostasis, form myelin, and participate in signal transmission in the nervous system.


go_id: GO:0042066
term: perineurial glial growth
ontology: BP
definition:
Glial cell growth that occurs in the perineurium, a cell layer that ensheaths projections of peripheral nerves, such as motor axons.


go_id: GO:0042067
term: establishment of ommatidial planar polarity
ontology: BP
definition:
The specification of polarized ommatidia. Ommatidia occur in two chiral forms. The trapezoidal arrangement of photoreceptors in the dorsal part of the eye is the mirror image of that in the ventral part.


go_id: GO:0042068
term: regulation of pteridine metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving pteridine.


go_id: GO:0042069
term: regulation of catecholamine metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving catecholamines.


go_id: GO:0042070
term: maintenance of oocyte nucleus location involved in oocyte dorsal/ventral axis specification
ontology: BP
definition:
Maintenance of the oocyte nucleus in a particular position within the cell during the establishment and maintenance of the axes of the oocyte. An example of this process is found In Drosophila melanogaster.


go_id: GO:0042071
term: leucokinin receptor activity
ontology: MF
definition:
Combining with a leucokinin, any of several octapeptide hormones found in insects, and transmitting the signal to initiate a change in cell activity.


go_id: GO:0042073
term: intraciliary transport
ontology: BP
definition:
The bidirectional movement of large protein complexes along microtubules within a cilium, mediated by motor proteins.


go_id: GO:0042074
term: cell migration involved in gastrulation
ontology: BP
definition:
The migration of individual cells within the blastocyst to help establish the multi-layered body plan of the organism (gastrulation). For example, the migration of cells from the surface to the interior of the embryo (ingression).


go_id: GO:0042075
ontology: BP
term:
nickel incorporation into nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide

definition:
The incorporation of nickel into a nickel-iron-sulfur cluster via pentakis-L-cysteinyl L-histidino nickel tetrairon pentasulfide, found in carbon monoxide dehydrogenase.


go_id: GO:0042076
term: protein phosphate-linked glycosylation
ontology: BP
definition:
The glycosylation of peptidyl-amino acids through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues.


go_id: GO:0042077
term: protein phosphate-linked glycosylation via serine
ontology: BP
definition:
The glycosylation of peptidyl-serine through a phosphoester bond forming, for example, GlcNAc-alpha-1-P-Ser residues.


go_id: GO:0042078
term: germ-line stem cell division
ontology: BP
definition:
The self-renewing division of a germline stem cell to produce a daughter stem cell and a daughter germ cell, which will divide to form the gametes.


go_id: GO:0042081
term: GSI anchor metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving glycosylsphingolipidinositol (GSI) anchors, which attach membrane proteins to the lipid bilayer of the cell membrane.


go_id: GO:0042082
term: GSI anchor biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of a glycosylsphingolipidinositol (GSI) anchor that attaches some membrane proteins to the lipid bilayer of the cell membrane. The sphingolipid group is linked, via the C-6 hydroxyl residue of inositol to a carbohydrate chain which is itself linked to the protein via a ethanolamine phosphate group, its amino group forming an amide linkage with the C-terminal carboxyl of the protein. Some GSI anchors have variants on this canonical linkage.


go_id: GO:0042083
term: 5,10-methylenetetrahydrofolate-dependent methyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5,10-methylenetetrahydrofolate.


go_id: GO:0042084
term: 5-methyltetrahydrofolate-dependent methyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydrofolate.


go_id: GO:0042085
term: 5-methyltetrahydropteroyltri-L-glutamate-dependent methyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a methyl group to an acceptor molecule; dependent on the presence of 5-methyltetrahydropteroyltri-L-glutamate.


go_id: GO:0042086
term: 5-methyl-5,6,7,8-tetrahydromethanopterin-dependent methyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a methyl group to an acceptor molecule, dependent on the presence of 5-methyl-5,6,7,8-tetrahydromethanopterin.


go_id: GO:0042088
term: T-helper 1 type immune response
ontology: BP
definition:
An immune response which is associated with resistance to intracellular bacteria, fungi, and protozoa, and pathological conditions such as arthritis, and which is typically orchestrated by the production of particular cytokines by T-helper 1 cells, most notably interferon-gamma, IL-2, and lymphotoxin.


go_id: GO:0042092
term: type 2 immune response
ontology: BP
definition:
An immune response which is associated with resistance to extracellular organisms such as helminths and pathological conditions such as allergy, which is orchestrated by the production of particular cytokines, most notably IL-4, IL-5, IL-10, and IL-13, by any of a variety of cell types including T-helper 2 cells, eosinophils, basophils, mast cells, and nuocytes, resulting in enhanced production of certain antibody isotypes and other effects.


go_id: GO:0042093
term: T-helper cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized thymocyte acquires specialized features of a T-helper cell.


go_id: GO:0042101
term: T cell receptor complex
ontology: CC
definition:
A protein complex that contains a disulfide-linked heterodimer of T cell receptor (TCR) chains, which are members of the immunoglobulin superfamily, and mediates antigen recognition, ultimately resulting in T cell activation. The TCR heterodimer is associated with the CD3 complex, which consists of the nonpolymorphic polypeptides gamma, delta, epsilon, zeta, and, in some cases, eta (an RNA splice variant of zeta) or Fc epsilon chains.


go_id: GO:0042105
term: alpha-beta T cell receptor complex
ontology: CC
definition:
A T cell receptor complex in which the TCR heterodimer comprises alpha and beta chains, associated with the CD3 complex; recognizes a complex consisting of an antigen-derived peptide bound to a class I or class II MHC protein.


go_id: GO:0042106
term: gamma-delta T cell receptor complex
ontology: CC
definition:
A T cell receptor complex in which the TCR heterodimer comprises gamma and delta chains, associated with the CD3 complex; recognizes antigen directly, without a requirement for processing and presentation by an MHC protein.


go_id: GO:0042110
term: T cell activation
ontology: BP
definition:
The change in morphology and behavior of a mature or immature T cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


go_id: GO:0042113
term: B cell activation
ontology: BP
definition:
The change in morphology and behavior of a mature or immature B cell resulting from exposure to a mitogen, cytokine, chemokine, cellular ligand, or an antigen for which it is specific.


go_id: GO:0042116
term: macrophage activation
ontology: BP
definition:
A change in morphology and behavior of a macrophage resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.


go_id: GO:0042117
term: monocyte activation
ontology: BP
definition:
The change in morphology and behavior of a monocyte resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.


go_id: GO:0042118
term: endothelial cell activation
ontology: BP
definition:
The change in morphology and behavior of an endothelial cell resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.


go_id: GO:0042119
term: neutrophil activation
ontology: BP
definition:
The change in morphology and behavior of a neutrophil resulting from exposure to a cytokine, chemokine, cellular ligand, or soluble factor.


go_id: GO:0042120
term: alginic acid metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).


go_id: GO:0042121
term: alginic acid biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).


go_id: GO:0042122
term: alginic acid catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of alginic acid, a hydrophilic polysaccharide occurring in, for example, the cell walls of brown algae (brown seaweeds).


go_id: GO:0042124
term: 1,3-beta-glucanosyltransferase activity
ontology: MF
definition:
Catalysis of the splitting and linkage of (1->3)-beta-D-glucan molecules, resulting in (1->3)-beta-D-glucan chain elongation.


go_id: GO:0042126
term: nitrate metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving nitrates, inorganic or organic salts and esters of nitric acid.


go_id: GO:0042128
term: nitrate assimilation
ontology: BP
definition:
The nitrogen metabolic process that encompasses the uptake of nitrate from the environment and reduction to ammonia, and results in the incorporation of nitrogen derived from nitrate into cellular substances.


go_id: GO:0042133
term: neurotransmitter metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving neurotransmitters, any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.


go_id: GO:0042135
term: neurotransmitter catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.


go_id: GO:0042136
term: neurotransmitter biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell.


go_id: GO:0042137
term: sequestering of neurotransmitter
ontology: BP
definition:
The process of binding or confining a neurotransmitter such that it is separated from other components of a biological system.


go_id: GO:0042138
term: meiotic DNA double-strand break formation
ontology: BP
definition:
The cell cycle process in which double-strand breaks are generated at defined hotspots throughout the genome during meiosis I. This results in the initiation of meiotic recombination.


go_id: GO:0042139
term: early meiotic recombination nodule assembly
ontology: BP
definition:
During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during leptotene and zygotene.


go_id: GO:0042140
term: late meiotic recombination nodule assembly
ontology: BP
definition:
During meiosis, the aggregation, arrangement and bonding together of strand exchange proteins (recombinases) to form small, electron dense structures in association with meiotic chromosomes during pachytene. Involved in the catalysis crossing over.


go_id: GO:0042147
term: retrograde transport, endosome to Golgi
ontology: BP
definition:
The directed movement of membrane-bounded vesicles from endosomes back to the trans-Golgi network where they are recycled for further rounds of transport.


go_id: GO:0042148
term: strand invasion
ontology: BP
definition:
The process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules.


go_id: GO:0042149
term: cellular response to glucose starvation
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of glucose.


go_id: GO:0042150
term: plasmid recombination
ontology: BP
definition:
A process of DNA recombination occurring within a plasmid or between plasmids and other plasmids or DNA molecules.


go_id: GO:0042151
term: nematocyst
ontology: CC
definition:
An organelle found in cnidoblast (nematoblast) cells. When matured, these stinging organelles store toxins and can deliver them when the cnidocil (a short extension of the cnidocyst) is stimulated by a prey or another stimulus.


go_id: GO:0042152
term: RNA-mediated DNA recombination
ontology: BP
definition:
The reverse transcription of an RNA molecule followed by recombination between the resultant cDNA and its homologous chromosomal allele.


go_id: GO:0042157
term: lipoprotein metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.


go_id: GO:0042158
term: lipoprotein biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.


go_id: GO:0042159
term: lipoprotein catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids.


go_id: GO:0042160
term: lipoprotein modification
ontology: BP
definition:
The chemical reactions and pathways resulting in the covalent alteration of one or more amino acid or lipid residues occurring in a lipoprotein, any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids.


go_id: GO:0042162
term: telomeric DNA binding
ontology: MF
definition:
Binding to a telomere, a specific structure at the end of a linear chromosome required for the integrity and maintenance of the end.


go_id: GO:0042165
term: neurotransmitter binding
ontology: MF
definition:
Binding to a neurotransmitter, any chemical substance that is capable of transmitting (or inhibiting the transmission of) a nerve impulse from a neuron to another cell.


go_id: GO:0042166
term: acetylcholine binding
ontology: MF
definition:
Binding to acetylcholine, an acetic acid ester of the organic base choline that functions as a neurotransmitter, released at the synapses of parasympathetic nerves and at neuromuscular junctions.


go_id: GO:0042167
term: heme catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.


go_id: GO:0042168
term: heme metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring.


go_id: GO:0042169
term: SH2 domain binding
ontology: MF
definition:
Binding to a SH2 domain (Src homology 2) of a protein, a protein domain of about 100 amino-acid residues and belonging to the alpha + beta domain class.


go_id: GO:0042171
term: lysophosphatidic acid acyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of acyl groups from an acyl-CoA to lysophosphatidic acid to form phosphatidic acid.


go_id: GO:0042175
term: nuclear outer membrane-endoplasmic reticulum membrane network
ontology: CC
definition:
The continuous network of membranes encompassing the nuclear outer membrane and the endoplasmic reticulum membrane.


go_id: GO:0042176
term: regulation of protein catabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds.


go_id: GO:0042177
term: negative regulation of protein catabolic process
ontology: BP
definition:
Any process that stops, prevents or reduces the frequency, rate or extent of protein catabolic process.


go_id: GO:0042178
term: xenobiotic catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a xenobiotic compound, a compound foreign to the organim exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical.


go_id: GO:0042179
term: nicotine biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of nicotine, (S)(-)-3-(1-methyl-2-pyrrolidinyl)pyridine.


go_id: GO:0042180
term: cellular ketone metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.


go_id: GO:0042181
term: ketone biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.


go_id: GO:0042182
term: ketone catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.


go_id: GO:0042183
term: formate catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of formate, also known as methanoate, the anion HCOO- derived from methanoic (formic) acid.


go_id: GO:0042184
term: xylene catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of xylene, a mixture of three colorless, aromatic hydrocarbon liquids, ortho-, meta- and para-xylene.


go_id: GO:0042185
term: m-xylene catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of m-xylene, 1,3-dimethylbenzene, a colorless, liquid aromatic hydrocarbon.


go_id: GO:0042186
term: o-xylene catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of o-xylene, (1,2-dimethylbenzene) a colorless, liquid aromatic hydrocarbon.


go_id: GO:0042187
term: p-xylene catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of p-xylene (1,4-dimethylbenzene), a colorless, liquid aromatic hydrocarbon.


go_id: GO:0042188
term: 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of 1,1,1-trichloro-2,2-bis-(4-chlorophenyl)ethane (DDT), a chlorinated broad spectrum contact insecticide.


go_id: GO:0042189
term: vanillin biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods.


go_id: GO:0042190
term: vanillin catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of vanillin, an aromatic hydrocarbon which occurs naturally in black vanilla bean pods.


go_id: GO:0042191
term: methylmercury metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving methylmercury (MeHg+), a highly toxic organometal which can accumulate in tissues, particularly in fish species.


go_id: GO:0042192
term: methylmercury biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of methylmercury (MeHg+), a highly toxic organometal.


go_id: GO:0042193
term: methylmercury catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of methylmercury (MeHg+), a highly toxic organometal.


go_id: GO:0042194
term: quinate biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of quinate, the anion of quinic acid.


go_id: GO:0042195
term: aerobic gallate catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of gallate, the anion of gallic acid, in the presence of oxygen.


go_id: GO:0042196
term: chlorinated hydrocarbon metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving chlorinated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with chlorine atoms.


go_id: GO:0042197
term: halogenated hydrocarbon metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving halogenated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with halogen atoms. Halogens include fluorine, chlorine, bromine and iodine.


go_id: GO:0042198
term: nylon metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving nylon, a polymer where the main polymer chain comprises recurring amide groups; these compounds are generally formed from combinations of diamines, diacids and amino acids.


go_id: GO:0042199
term: cyanuric acid metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving cyanuric acid, a suspected gastrointestinal or liver toxicant, and a potential degradation product of triazine herbicides, such as atrazine and simazine. It is widely used for the stabilization of available chlorine in swimming pool water and is also the starting compound for the synthesis of many organic derivatives.


go_id: GO:0042200
term: cyanuric acid catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of cyanuric acid, a potential degradation product of triazine herbicides.


go_id: GO:0042201
term: N-cyclopropylmelamine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving N-cyclopropylmelamine, a triazine compound commonly used as an insect growth regulator insecticide.


go_id: GO:0042202
term: N-cyclopropylmelamine catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of N-cyclopropylmelamine, a triazine compound commonly used as an insecticide.


go_id: GO:0042203
term: toluene catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of toluene, a volatile monoaromatic hydrocarbon found in crude petroleum and petroleum products.


go_id: GO:0042204
term: s-triazine compound catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of any s-triazine compound. These compounds include many pesticides of widespread use in agriculture, and are characterized by a symmetrical hexameric ring consisting of alternating carbon and nitrogen atoms.


go_id: GO:0042205
term: chlorinated hydrocarbon catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of chlorinated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with chlorine atoms.


go_id: GO:0042206
term: halogenated hydrocarbon catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of halogenated hydrocarbons, compounds derived from hydrocarbons by replacing one or more hydrogen atoms with halogen atoms.


go_id: GO:0042207
term: styrene catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of styrene, an aromatic hydrocarbon liquid used in the manufacture of polystyrene.


go_id: GO:0042208
term: propylene catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of propylene, an alkene produced by catalytic or thermal cracking of hydrocarbons or as a by-product of petroleum refining.


go_id: GO:0042209
term: orcinol catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of orcinol (5-methyl-1,3-benzenediol), an aromatic compound derived from the fermentation of lichen and synthesized by some higher plants.


go_id: GO:0042210
term: octamethylcyclotetrasiloxane catabolic process to dimethylsilanediol
ontology: BP
definition:
The anaerobic chemical reactions and pathways resulting in the breakdown of octamethylcyclotetrasiloxane into dimethylsilanediol. The former is a tetramer of the latter.


go_id: GO:0042211
term: dimethylsilanediol catabolic process
ontology: BP
definition:
The aerobic chemical reactions and pathways resulting in the breakdown of dimethylsilanediol, the smallest member of the dialkylsilanediols. Dimethylsilanediol is the monomer of polydimethylsiloxane, a compound which can be found in a wide range of industrial and consumer products.


go_id: GO:0042212
term: cresol metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving cresol, a mixture of the aromatic alcohol isoforms o-, p-, and m-cresol, which is obtained from coal tar or petroleum. The isomers are used as disinfectants, textile scouring agents, surfactants and as intermediates in the manufacture of salicylaldehyde, coumarin, and herbicides as well as being a major component of creosote.


go_id: GO:0042213
term: m-cresol catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of m-cresol (3-hydroxytoluene), the meta-isoform of cresol.


go_id: GO:0042214
term: terpene metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving terpenes, any of a large group of hydrocarbons that are made up of isoprene (C5H8) units which may be cyclic, acyclic or multicyclic, saturated or unsaturated, and may contain various functional groups.


go_id: GO:0042215
term: anaerobic phenol-containing compound metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving a phenol, any compound containing one or more hydroxyl groups directly attached to an aromatic carbon ring, in the absence of oxygen.


go_id: GO:0042216
term: phenanthrene catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of phenanthrene, a tricyclic aromatic hydrocarbon.


go_id: GO:0042217
term: 1-aminocyclopropane-1-carboxylate catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants.


go_id: GO:0042218
term: 1-aminocyclopropane-1-carboxylate biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of 1-aminocyclopropane-1-carboxylate, a natural product found in plant tissues. It is a key intermediate in the biosynthesis of ethylene (ethene), a fruit-ripening hormone in plants.


go_id: GO:0042219
term: cellular modified amino acid catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of compounds derived from amino acids, organic acids containing one or more amino substituents.


go_id: GO:0042220
term: response to cocaine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cocaine stimulus. Cocaine is a crystalline alkaloid obtained from the leaves of the coca plant.


go_id: GO:0042221
term: response to chemical
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a chemical stimulus.


go_id: GO:0042242
term: cobyrinic acid a,c-diamide synthase activity
ontology: MF
definition:
Catalysis of the conversion of cobyrinic acid to cobyrinic acid a,c-diamide via the intermediate formation of cobyrinic acid c-monoamide.


go_id: GO:0042243
term: asexual spore wall assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form an asexual spore wall, the specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in Bacterial and Fungal species.


go_id: GO:0042244
term: spore wall assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a spore wall; a spore wall is the specialized envelope lying outside the cell membrane of a spore.


go_id: GO:0042247
term: establishment of planar polarity of follicular epithelium
ontology: BP
definition:
Coordinated organization of groups of cells in the plane of a follicular epithelium, such that they all orient to similar coordinates.


go_id: GO:0042249
term: establishment of planar polarity of embryonic epithelium
ontology: BP
definition:
Coordinated organization of groups of cells in the plane of an embryonic epithelium, such that they all orient to similar coordinates.


go_id: GO:0042252
term: establishment of planar polarity of larval imaginal disc epithelium
ontology: BP
definition:
Coordinated organization of groups of cells in the plane of a larval imaginal disc epithelium, such that they all orient to similar coordinates.


go_id: GO:0042254
term: ribosome biogenesis
ontology: BP
definition:
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits; includes transport to the sites of protein synthesis.


go_id: GO:0042256
term: mature ribosome assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of the large and small ribosomal subunits into a functional ribosome.


go_id: GO:0042259
term: peptidyl-L-beta-methylthioasparagine biosynthetic process from peptidyl-asparagine
ontology: BP
definition:
The modification of peptidyl-asparagine to form peptidyl-L-beta-methylthioasparagine, typical of bacterial ribosomal protein S12.


go_id: GO:0042263
term: neuropeptide F receptor activity
ontology: MF
definition:
Combining with neuropeptide F and transmitting the signal within the cell to initiate a change in cell activity. Neuropeptide F is an arthropod peptide of more than 28 residues (typically 28-45) with a consensus C-terminal RxRFamide (commonly RPRFa, but also RVRFa.


go_id: GO:0042267
term: natural killer cell mediated cytotoxicity
ontology: BP
definition:
The directed killing of a target cell by a natural killer cell through the release of granules containing cytotoxic mediators or through the engagement of death receptors.


go_id: GO:0042268
term: regulation of cytolysis
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the rupture of cell membranes and the loss of cytoplasm.


go_id: GO:0042269
term: regulation of natural killer cell mediated cytotoxicity
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of natural killer cell mediated cytotoxicity.


go_id: GO:0042272
term: nuclear RNA export factor complex
ontology: CC
definition:
A protein complex that contains two proteins (know in several organisms, including Drosophila, as NXF1 and NXF2) and is required for the export of the majority of mRNAs from the nucleus to the cytoplasm; localized in the nucleoplasm and at both the nucleoplasmic and cytoplasmic faces of the nuclear pore complex; shuttles between the nucleus and the cytoplasm.


go_id: GO:0042273
term: ribosomal large subunit biogenesis
ontology: BP
definition:
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a large ribosomal subunit; includes transport to the sites of protein synthesis.


go_id: GO:0042274
term: ribosomal small subunit biogenesis
ontology: BP
definition:
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a small ribosomal subunit; includes transport to the sites of protein synthesis.


go_id: GO:0042275
term: error-free postreplication DNA repair
ontology: BP
definition:
The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA via processes such as template switching, which does not remove the replication-blocking lesions but does not increase the endogenous mutation rate.


go_id: GO:0042276
term: error-prone translesion synthesis
ontology: BP
definition:
The conversion of DNA-damage induced single-stranded gaps into large molecular weight DNA after replication by using a specialized DNA polymerase or replication complex to insert a defined nucleotide across the lesion. This process does not remove the replication-blocking lesions and causes an increase in the endogenous mutation level. For example, in E. coli, a low fidelity DNA polymerase, pol V, copies lesions that block replication fork progress. This produces mutations specifically targeted to DNA template damage sites, but it can also produce mutations at undamaged sites.


