# go_term

go_id: GO:0086019
term: cell-cell signaling involved in cardiac conduction
ontology: BP
definition:
Any process that mediates the transfer of information from one cell to another and contributes to the heart process that regulates cardiac muscle contraction; beginning with the generation of an action potential in the sinoatrial node and ending with regulation of contraction of the myocardium.


go_id: GO:0086020
ontology: MF
term:
gap junction channel activity involved in SA node cell-atrial cardiac muscle cell electrical coupling

definition:
A wide pore channel activity that enables a direct cytoplasmic connection from an SA node cell to an atrial cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


go_id: GO:0086021
term: SA node cell to atrial cardiac muscle cell communication by electrical coupling
ontology: BP
definition:
The process that mediates signaling interactions between an SA node cardiomyocyte and an atrial cardiomyocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels.


go_id: GO:0086022
term: SA node cell-atrial cardiac muscle cell adhesion involved in cell communication
ontology: BP
definition:
The attachment of SA node cardiomyocyte to an atrial cardiomyocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate.


go_id: GO:0086023
term: adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process
ontology: BP
definition:
The series of molecular signals beginning with a G protein-coupled adrenergic cell surface receptor combining with epinephrine or norepinephrine, to activate adenylate cyclase, which contributes to a circulatory system process carried out by the heart.


go_id: GO:0086024
ontology: BP
term:
adenylate cyclase-activating adrenergic receptor signaling pathway involved in positive regulation of heart rate

definition:
An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of heart contraction. Binding of adrenalin or noradrenalin to a beta-adrenergic receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gs protein. Gs activates adenylate cyclase to increase intracellular cyclic-AMP (cAMP) levels. cAMP binds directly to F-channels to allow an inward flow of sodium (known as funny current, or If current). The funny current is responsible for membrane depolarization and an increase in heart rate.


go_id: GO:0086026
term: atrial cardiac muscle cell to AV node cell signaling
ontology: BP
definition:
Any process that mediates the transfer of information from an atrial cardiomyocyte to an AV node cell.


go_id: GO:0086027
term: AV node cell to bundle of His cell signaling
ontology: BP
definition:
Any process that mediates the transfer of information from an AV node cardiac muscle cell to a bundle of His cardiomyocyte.


go_id: GO:0086028
term: bundle of His cell to Purkinje myocyte signaling
ontology: BP
definition:
Any process that mediates the transfer of information from a bundle of His cardiomyocyte to a Purkinje myocyte.


go_id: GO:0086029
term: Purkinje myocyte to ventricular cardiac muscle cell signaling
ontology: BP
definition:
Any process that mediates the transfer of information from a Purkinje myocyte to a ventricular cardiac muscle cell.


go_id: GO:0086030
ontology: BP
term:
adenylate cyclase-activating adrenergic receptor signaling pathway involved in cardiac muscle relaxation

definition:
An adrenergic receptor signaling pathway that contributes to a reduction in cardiac muscle contraction. Beta-adrenergic receptor-induced cardiac relaxation is achieved by a GPCR-activated adenylate cyclase generating cAMP; cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the sarcoplasmic reticulum (SR) membrane protein PLB. In its non-phosphorylated state, PLB acts as an inhibitor of the ATPase Ca(2+) pump of the cardiac SR (SERCA2a); inhibition of the pump is relieved upon phosphorylation. The pump removes Ca(2+) from the cytoplasm, thereby preventing cytosolic Ca(2+)-dependent activation of contractile proteins, leading to enhanced muscle relaxation.


go_id: GO:0086033
ontology: BP
term:
G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate

definition:
A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the alpha subunit of a coupled G-protein binding to GTP. This results in the separation of the beta-gamma complex from the alpha subunit. Both the alpha subunit, and the beta-gamma complex can continue to signal to bring about membrane hyperpolarization and a reduction in heart rate.


go_id: GO:0086036
term: regulation of cardiac muscle cell membrane potential
ontology: BP
definition:
Any process that modulates the establishment or extent of a membrane potential in a cardiac muscle cell (a cardiomyocyte). A membrane potential is the electric potential existing across any membrane arising from charges in the membrane itself and from the charges present in the media on either side of the membrane.


go_id: GO:0086037
ontology: MF
term:
P-type sodium:potassium-exchanging transporter activity involved in regulation of cardiac muscle cell membrane potential

definition:
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + Na+(in) + K+(out) = ADP + phosphate + Na+(out) + K+(in), that contributes to regulating the membrane potential of a cardiac muscle cell.


go_id: GO:0086038
term: calcium:sodium antiporter activity involved in regulation of cardiac muscle cell membrane potential
ontology: MF
definition:
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: Ca2+(in) + Na+(out) = Ca2+(out) + Na+(in), which contributes to regulating the membrane potential of a cardiac muscle cell.


go_id: GO:0086039
ontology: MF
term:
P-type calcium transporter activity involved in regulation of cardiac muscle cell membrane potential

definition:
A calcium-transporting P-type ATPase activity involved in regulation of the plasma membrane potential.


go_id: GO:0086040
term: sodium:proton antiporter activity involved in regulation of cardiac muscle cell membrane potential
ontology: MF
definition:
Enables the transfer of a solute or solutes from one side of a cardiac muscle cell membrane to the other according to the reaction: Na+(out) + H+(in) = Na+(in) + H+(out). This transfer contributes to the regulation of the cardiac muscle cell plasma membrane potential.


go_id: GO:0086041
term: voltage-gated potassium channel activity involved in SA node cell action potential depolarization
ontology: MF
definition:
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0086044
term: atrial cardiac muscle cell to AV node cell communication by electrical coupling
ontology: BP
definition:
The process that mediates signaling interactions between an atrial cardiomyocyte and an AV node cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.


go_id: GO:0086045
term: membrane depolarization during AV node cell action potential
ontology: BP
definition:
The process in which AV node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


go_id: GO:0086046
term: membrane depolarization during SA node cell action potential
ontology: BP
definition:
The process in which SA node cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


go_id: GO:0086047
term: membrane depolarization during Purkinje myocyte cell action potential
ontology: BP
definition:
The process in which Purkinje myocyte membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


go_id: GO:0086048
term: membrane depolarization during bundle of His cell action potential
ontology: BP
definition:
The process in which bundle of His cardiac muscle cell membrane potential changes in the depolarizing direction from the negative resting potential towards the positive membrane potential that will be the peak of the action potential.


go_id: GO:0086049
term: membrane repolarization during AV node cell action potential
ontology: BP
definition:
The process in which ions are transported across a membrane such that the AV node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.


go_id: GO:0086050
term: membrane repolarization during bundle of His cell action potential
ontology: BP
definition:
The process in which ions are transported across a membrane such that the bundle of His cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.


go_id: GO:0086051
term: membrane repolarization during Purkinje myocyte action potential
ontology: BP
definition:
The process in which ions are transported across a membrane such that the Purkinje myocyte membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.


go_id: GO:0086052
term: membrane repolarization during SA node cell action potential
ontology: BP
definition:
The process in which an SA node cardiac muscle cell membrane potential changes in the direction from the positive membrane potential at the peak of the action potential towards the negative resting potential.


go_id: GO:0086053
term: AV node cell to bundle of His cell communication by electrical coupling
ontology: BP
definition:
The process that mediates signaling interactions between an AV node cardiomyocyte and a bundle of His cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.


go_id: GO:0086054
term: bundle of His cell to Purkinje myocyte communication by electrical coupling
ontology: BP
definition:
The process that mediates signaling interactions between a bundle of His cardiac muscle cell and a Purkinje myocyte by transfer of current between their adjacent cytoplasms via intercellular protein channels.


go_id: GO:0086055
term: Purkinje myocyte to ventricular cardiac muscle cell communication by electrical coupling
ontology: BP
definition:
The process that mediates signaling interactions between a Purkinje myocyte and a ventricular cardiac muscle cell by transfer of current between their adjacent cytoplasms via intercellular protein channels.


go_id: GO:0086056
term: voltage-gated calcium channel activity involved in AV node cell action potential
ontology: MF
definition:
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an AV node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0086057
term: voltage-gated calcium channel activity involved in bundle of His cell action potential
ontology: MF
definition:
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of a bundle of His cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0086058
term: voltage-gated calcium channel activity involved in Purkinje myocyte cell action potential
ontology: MF
definition:
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an Purkinje myocyte cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0086059
term: voltage-gated calcium channel activity involved SA node cell action potential
ontology: MF
definition:
Enables the transmembrane transfer of a calcium ion by a voltage-gated channel across the plasma membrane of an SA node cardiac muscle cell that contributes to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0086060
term: voltage-gated sodium channel activity involved in AV node cell action potential
ontology: MF
definition:
Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0086061
term: voltage-gated sodium channel activity involved in bundle of His cell action potential
ontology: MF
definition:
Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a bundle of His cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0086062
term: voltage-gated sodium channel activity involved in Purkinje myocyte action potential
ontology: MF
definition:
Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0086063
term: voltage-gated sodium channel activity involved in SA node cell action potential
ontology: MF
definition:
Enables the transmembrane transfer of a sodium ion by a voltage-gated channel through the plasma membrane of an SA node cardiac muscle cell contributing to the depolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0086064
term: cell communication by electrical coupling involved in cardiac conduction
ontology: BP
definition:
The process that mediates signaling interactions between one cell and another cell by transfer of current between their adjacent cytoplasms via intercellular protein channels and contributes to the process of cardiac conduction.


go_id: GO:0086065
term: cell communication involved in cardiac conduction
ontology: BP
definition:
Any process that mediates interactions between a cell and its surroundings that contributes to the process of cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


go_id: GO:0086066
term: atrial cardiac muscle cell to AV node cell communication
ontology: BP
definition:
The process that mediates interactions between an atrial cardiomyocyte and its surroundings that contributes to the process of the atrial cardiomyocyte communicating with an AV node cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


go_id: GO:0086067
term: AV node cell to bundle of His cell communication
ontology: BP
definition:
The process that mediates interactions between an AV node cell and its surroundings that contributes to the process of the AV node cell communicating with a bundle of His cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


go_id: GO:0086068
term: Purkinje myocyte to ventricular cardiac muscle cell communication
ontology: BP
definition:
The process that mediates interactions between a Purkinje myocyte and its surroundings that contributes to the process of the Purkinje myocyte communicating with a ventricular cardiac muscle cell in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


go_id: GO:0086069
term: bundle of His cell to Purkinje myocyte communication
ontology: BP
definition:
The process that mediates interactions between a bundle of His cell and its surroundings that contributes to the process of the bundle of His cell communicating with a Purkinje myocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


go_id: GO:0086070
term: SA node cell to atrial cardiac muscle cell communication
ontology: BP
definition:
The process that mediates interactions between an SA node cardiomyocyte and its surroundings that contributes to the process of the SA node cardiomyocyte communicating with an atrial cardiomyocyte in cardiac conduction. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.


go_id: GO:0086071
term: atrial cardiac muscle cell-AV node cell adhesion involved in cell communication
ontology: BP
definition:
The attachment of an atrial cardiomyocyte to an AV node cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate.


go_id: GO:0086072
term: AV node cell-bundle of His cell adhesion involved in cell communication
ontology: BP
definition:
The attachment of an AV node cell to an bundle of His cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate.


go_id: GO:0086073
term: bundle of His cell-Purkinje myocyte adhesion involved in cell communication
ontology: BP
definition:
The attachment of a bundle of His cell to a Purkinje myocyte via adhesion molecules that results in the cells being juxtaposed so that they can communicate.


go_id: GO:0086074
term: Purkinje myocyte-ventricular cardiac muscle cell adhesion involved in cell communication
ontology: BP
definition:
The attachment of an Purkinje myocyte to a ventricular cardiac muscle cell via adhesion molecules that results in the cells being juxtaposed so that they can communicate.


go_id: GO:0086075
term: gap junction channel activity involved in cardiac conduction electrical coupling
ontology: MF
definition:
A wide pore channel activity that enables a direct cytoplasmic connection from one cardiomyocyte to an adjacent cardiomyocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


go_id: GO:0086076
ontology: MF
term:
gap junction channel activity involved in atrial cardiac muscle cell-AV node cell electrical coupling

definition:
A wide pore channel activity that enables a direct cytoplasmic connection from an atrial cardiomyocyte to an AV node cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


go_id: GO:0086077
term: gap junction channel activity involved in AV node cell-bundle of His cell electrical coupling
ontology: MF
definition:
A wide pore channel activity that enables a direct cytoplasmic connection from an AV node cell to a bundle of His cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


go_id: GO:0086078
term: gap junction channel activity involved in bundle of His cell-Purkinje myocyte electrical coupling
ontology: MF
definition:
A wide pore channel activity that enables a direct cytoplasmic connection from a bundle of His cell to a Purkinje myocyte. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


go_id: GO:0086079
ontology: MF
term:
gap junction channel activity involved in Purkinje myocyte-ventricular cardiac muscle cell electrical coupling

definition:
A wide pore channel activity that enables a direct cytoplasmic connection from a Purkinje myocyte to a ventricular cardiac muscle cell. The gap junction passes electrical signals between the cells contributing to cardiac conduction.


go_id: GO:0086080
term: protein binding involved in heterotypic cell-cell adhesion
ontology: MF
definition:
Binding to a protein or protein complex contributing to the adhesion of two different types of cells.


go_id: GO:0086081
term: cell adhesive protein binding involved in atrial cardiac muscle cell-AV node cell communication
ontology: MF
definition:
Binding to a protein or protein complex that results in the connection of an atrial cardiomyocyte with an AV node cell and contributes to the communication between the two cells.


go_id: GO:0086082
term: cell adhesive protein binding involved in AV node cell-bundle of His cell communication
ontology: MF
definition:
Binding to a protein or protein complex that results in the connection of an AV node cell with a bundle of His cell and contributes to the communication between the two cells.


go_id: GO:0086083
term: cell adhesive protein binding involved in bundle of His cell-Purkinje myocyte communication
ontology: MF
definition:
Binding to a protein or protein complex that results in the connection of a bundle of His cell with a Purkinje myocyte and contributes to the communication between the two cells.


go_id: GO:0086084
ontology: MF
term:
cell adhesive protein binding involved in Purkinje myocyte-ventricular cardiac muscle cell communication

definition:
Binding to a protein or protein complex that results in the connection of a Purkinje myocyte with an ventricular cardiac muscle cell and contributes to the communication between the two cells.


go_id: GO:0086085
ontology: MF
term:
cell adhesive protein binding involved in SA cardiac muscle cell-atrial cardiac muscle cell communication

definition:
Binding to a protein or protein complex that results in the connection of an SA cardiomyocyte with an atrial cardiomyocyte and contributes to the communication between the two cells.


go_id: GO:0086086
term: voltage-gated potassium channel activity involved in AV node cell action potential repolarization
ontology: MF
definition:
Catalysis of the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an AV node cardiac muscle cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0086087
ontology: MF
term:
voltage-gated potassium channel activity involved in bundle of His cell action potential repolarization

definition:
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a bundle of His cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0086088
ontology: MF
term:
voltage-gated potassium channel activity involved in Purkinje myocyte action potential repolarization

definition:
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of a Purkinje myocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0086089
ontology: MF
term:
voltage-gated potassium channel activity involved in atrial cardiac muscle cell action potential repolarization

definition:
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an atrial cardiomyocyte contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0086090
term: voltage-gated potassium channel activity involved in SA node cell action potential repolarization
ontology: MF
definition:
Enables the transmembrane transfer of a potassium ion by a voltage-gated channel through the plasma membrane of an SA node cell contributing to the repolarization phase of an action potential. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded.


go_id: GO:0086092
term: regulation of the force of heart contraction by cardiac conduction
ontology: BP
definition:
A cardiac conduction process that modulates the extent of heart contraction, changing the force with which blood is propelled.


go_id: GO:0086093
term: G protein-coupled acetylcholine receptor signaling pathway involved in heart process
ontology: BP
definition:
A G protein-coupled acetylcholine receptor signaling pathway, which contributes to a circulatory system process carried out by the heart.


go_id: GO:0086094
ontology: BP
term:
positive regulation of ryanodine-sensitive calcium-release channel activity by adrenergic receptor signaling pathway involved in positive regulation of cardiac muscle contraction

definition:
An adrenergic receptor signaling pathway that contributes to an increase in frequency or rate of cardiac muscle contraction through phosphorylation and enhancement of the ryanodine receptor, a calcium-activated calcium-release channel found in the membrane of the sarcoplasmic reticulum. An adrenergic receptor-activated adenylate cyclase generates cAMP. cAMP then activates the cAMP-dependent protein kinase A (PKA), which phosphorylates the ryanodine receptor (RyR). PKA-phosphorylation of RyR enhances channel activity by sensitizing the channel to cytosolic calcium. Cytosolic calcium stimulates contractile proteins to promote muscle contraction.


go_id: GO:0086095
ontology: BP
term:
positive regulation of IKACh channel activity by G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate

definition:
A G protein-coupled acetylcholine receptor signaling pathway that contributes to a decrease in frequency or rate of heart contraction through activation of the IKACh potassium channel. Binding of acetylcholine to a G protein-coupled acetylcholine receptor (muscarinic receptor) on the surface of the signal-receiving cell results in liberation of the G-beta/gamma complex from the alpha subunit. The G-beta/gamma complex binds directly to the inward-rectifying potassium channel IKACh. Once the ion channel is activated, potassium ions (K+) flow out of the cell and cause it to hyperpolarize. In its hyperpolarized state, action potentials cannot be fired as quickly as possible, which slows the heart rate.


go_id: GO:0086096
term: adenylate cyclase-inhibiting adrenergic receptor signaling pathway involved in heart process
ontology: BP
definition:
An adenylate cyclase-inhibiting adrenergic receptor signaling pathway which contributes to a circulatory system process carried out by the heart.


go_id: GO:0086097
term: phospholipase C-activating angiotensin-activated signaling pathway
ontology: BP
definition:
A phospholipase C-activating G protein-coupled receptor signaling pathway initiated by angiotensin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0086098
term: angiotensin-activated signaling pathway involved in heart process
ontology: BP
definition:
An angiotensin receptor signaling pathway which contributes to a circulatory system process carried out by the heart.


go_id: GO:0086099
term: phospholipase C-activating angiotensin-activated signaling pathway involved in heart process
ontology: BP
definition:
An angiotensin-mediated signaling pathway that contributes to a circulatory system process carried out by the heart, where the activated receptor transmits the signal via Gq-mediated activation of phospholipase C (PLC). PLC hydrolyses phosphatidylinositol 4,5-bisphosphate (PIP2) into the second messengers inositol-1,4,5,-triphosphate (IP3) and diacylglycerol (DAG). DAG activates protein kinase C (PKC), whilst IP3 binds intracellular receptors to induce the release of Ca2+ from intracellular stores.


go_id: GO:0086100
term: endothelin receptor signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway initiated by endothelin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0086101
term: endothelin receptor signaling pathway involved in heart process
ontology: BP
definition:
An endothelin receptor signaling pathway which contributes to a circulatory system process carried out by the heart.


go_id: GO:0086102
ontology: BP
term:
adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway involved in negative regulation of heart rate

definition:
An  adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway  that contributes to a decrease in frequency or rate of heart contraction through inhibition of adenylate cyclase (AC) activity. Binding of acetylcholine to a G protein-coupled (muscarinic) receptor on the surface of the signal-receiving cell results in the activation of an intracellular Gi/o protein. Gi/o inhibits adenylate cyclase to decrease cyclic-AMP (cAMP) levels. Since cAMP binds directly to F-channels to allow an inward flow of sodium (funny current, If current), a reduction in cAMP reduces the funny current to bring about membrane hyperpolarization and a decrease in heart rate.


go_id: GO:0086103
term: G protein-coupled receptor signaling pathway involved in heart process
ontology: BP
definition:
An G protein-coupled receptor signaling pathway which contributes to a circulatory system process carried out by the heart.


go_id: GO:0089700
term: protein kinase D signaling
ontology: BP
definition:
A series of reactions, mediated by the intracellular serine/threonine kinase protein kinase D, which occurs as a result of a single trigger reaction or compound.


go_id: GO:0089701
term: U2AF complex
ontology: CC
definition:
A heterodimeric protein complex consisting of conserved large and small U2AF subunits that contributes to spliceosomal RNA splicing by binding to consensus sequences at the 3' splice site. U2AF is required to stabilize the association of the U2 snRNP with the branch point.


go_id: GO:0089702
term: undecaprenyl-phosphate glucose phosphotransferase activity
ontology: MF
definition:
Catalysis of the reaction: UDP-glucose + ditrans,octacis-undecaprenyl phosphate = UMP + alpha-D-glucopyranosyl-diphospho-ditrans,octacis-undecaprenol.


go_id: GO:0089705
term: protein localization to outer membrane
ontology: BP
definition:
A process in which a protein is transported to, or maintained in, a specific location the cell outer membrane.


go_id: GO:0089710
term: endocytic targeting sequence binding
ontology: MF
definition:
Binding to a endocytic signal sequence, a specific peptide sequence, of 4-6 amino acids with an essential tyrosine (Y), found on cytoplasmic tails of some cell surface membrane proteins, which directs internalization by clathrin-coated pits.


go_id: GO:0089713
term: Cbf1-Met4-Met28 complex
ontology: CC
definition:
A heteromeric complex consisting of Cbf1 and basic leucine zipper (bZIP) containing transcriptional activators, Met4 and Met28, that forms over the sequence TCACGTG in the upstream activating sequence (UAS) of genes involved in sulfur amino acid metabolism, resulting in their transcriptional activation.


go_id: GO:0089714
term: UDP-N-acetyl-D-mannosamine dehydrogenase activity
ontology: MF
definition:
Catalysis of the reaction: UDP-N-acetyl-alpha-D-mannosamine + 2 NAD+ + H2O = UDP-N-acetyl-alpha-D-mannosaminuronate + 2 NADH + 2 H+.


go_id: GO:0089715
term: tRNA m6t6A37 methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + tRNA containing N6-threonylcarbamoyladenosine = S-adenosyl-L-homocysteine + tRNA containing N6-methylthreonylcarbamoyladenosine.


go_id: GO:0089716
term: Pip2-Oaf1 complex
ontology: CC
definition:
A heterodimeric complex consisting of Zn(2)Cys(6) containing transcription factors Pip2 and Oaf1. It binds to the oleate response element (ORE), found in the promoters of fatty acid-inducible genes in Saccharomyces where, in the presence of oleate this bound complex activates the transcription of genes encoding peroxisomal proteins.


go_id: GO:0089717
term: spanning component of membrane
ontology: CC
definition:
The component of a membrane consisting of gene products and protein complexes that have some part that spans both leaflets of the membrane.


go_id: GO:0089718
term: amino acid import across plasma membrane
ontology: BP
definition:
The directed movement of an amino acid from outside of a cell, across the plasma membrane and into the cytosol.


go_id: GO:0090001
term: replication fork arrest at tRNA locus
ontology: BP
definition:
A process that impedes the progress of the DNA replication fork at natural replication fork pausing sites within the eukaryotic tRNA transcription unit.


go_id: GO:0090006
term: regulation of linear element assembly
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of linear element assembly. Linear element assembly is the cell cycle process in which a proteinaceous scaffold, related to the synaptonemal complex, is assembled in association with S. pombe chromosomes during meiotic prophase.


go_id: GO:0090008
term: hypoblast development
ontology: BP
definition:
The process whose specific outcome is the progression of the hypoblast over time, from its formation to the mature structure. The hypoblast is a tissue formed from the inner cell mass that lies beneath the epiblast.


go_id: GO:0090009
term: primitive streak formation
ontology: BP
definition:
The developmental process pertaining to the initial formation of the primitive streak from unspecified parts. The primitive streak is a ridge of cells running along the midline of the embryo where the mesoderm ingresses. It defines the anterior-posterior axis.


go_id: GO:0090010
term: transforming growth factor beta receptor signaling pathway involved in primitive streak formation
ontology: BP
definition:
The series of molecular signals initiated by an extracellular ligand binding to a transforming growth factor beta receptor on the surface of a target cell, which contributes to the formation of the primitive streak.


go_id: GO:0090011
term: Wnt signaling pathway involved in primitive streak formation
ontology: BP
definition:
The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in transcription of target genes that contribute to the formation of the primitive streak.


go_id: GO:0090012
ontology: BP
term:
negative regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation

definition:
Any process that stops, prevents, or reduces the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak.


go_id: GO:0090013
ontology: BP
term:
regulation of transforming growth factor beta receptor signaling pathway involved in primitive streak formation

definition:
Any process that modulates the frequency, rate or extent of any TGF-beta receptor signaling pathway that contributes to the formation of the primitive streak.


go_id: GO:0090014
term: leaflet formation
ontology: BP
definition:
The developmental process pertaining to the initial formation of a leaflet from unspecified parts. A leaflet is one of the ultimate segments of a compound leaf.


go_id: GO:0090015
term: positive regulation of leaflet formation by auxin mediated signaling pathway
ontology: BP
definition:
Any process that increases the frequency, rate or extent of leaflet formation as a result of the series of molecular signals generated in response to detection of auxin.


go_id: GO:0090017
term: anterior neural plate formation
ontology: BP
definition:
The formation of anterior end of the flat, thickened layer of ectodermal cells known as the neural plate.


go_id: GO:0090018
term: posterior neural plate formation
ontology: BP
definition:
The formation of posterior end of the flat, thickened layer of ectodermal cells known as the neural plate.


go_id: GO:0090021
term: positive regulation of posterior neural plate formation by Wnt signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and increasing the rate or extent of posterior neural plate formation.


go_id: GO:0090022
term: regulation of neutrophil chemotaxis
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.


go_id: GO:0090023
term: positive regulation of neutrophil chemotaxis
ontology: BP
definition:
Any process that increases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.


go_id: GO:0090024
term: negative regulation of neutrophil chemotaxis
ontology: BP
definition:
Any process that decreases the frequency, rate, or extent of neutrophil chemotaxis. Neutrophil chemotaxis is the directed movement of a neutrophil cell, the most numerous polymorphonuclear leukocyte found in the blood, in response to an external stimulus, usually an infection or wounding.


go_id: GO:0090028
ontology: BP
term:
positive regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion

definition:
Any process that increases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion.


go_id: GO:0090029
ontology: BP
term:
negative regulation of pheromone-dependent signal transduction involved in conjugation with cellular fusion

definition:
Any process that decreases the frequency, rate or extent of pheromone-dependent signal transduction during conjugation with cellular fusion, a signal transduction process resulting in the relay, amplification or dampening of a signal generated in response to pheromone exposure in organisms that undergo conjugation with cellular fusion.


go_id: GO:0090030
term: regulation of steroid hormone biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones.


go_id: GO:0090031
term: positive regulation of steroid hormone biosynthetic process
ontology: BP
definition:
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones.


go_id: GO:0090032
term: negative regulation of steroid hormone biosynthetic process
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of steroid hormones,compounds with a 1, 2, cyclopentanoperhydrophenanthrene nucleus that act as hormones.


go_id: GO:0090033
term: positive regulation of filamentous growth
ontology: BP
definition:
Any process that increases the frequency, rate or extent of the process in which a multicellular organism or a group of unicellular organisms grow in a threadlike, filamentous shape.


go_id: GO:0090034
term: regulation of chaperone-mediated protein complex assembly
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.


go_id: GO:0090035
term: positive regulation of chaperone-mediated protein complex assembly
ontology: BP
definition:
Any process that increases the frequency, rate, or extent of chaperone-mediated protein complex assembly. Chaperone-mediated protein complex assembly is the aggregation, arrangement and bonding together of a set of components to form a protein complex, mediated by chaperone molecules that do not form part of the finished complex.


go_id: GO:0090036
term: regulation of protein kinase C signaling
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.


go_id: GO:0090037
term: positive regulation of protein kinase C signaling
ontology: BP
definition:
Any process that increases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.


go_id: GO:0090038
term: negative regulation of protein kinase C signaling
ontology: BP
definition:
Any process that decreases the frequency, rate, or extent of a series of reactions, mediated by the intracellular serine/threonine kinase protein kinase C, which occurs as a result of a single trigger reaction or compound.


go_id: GO:0090042
term: tubulin deacetylation
ontology: BP
definition:
The removal of an acetyl group from tubulin. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.


go_id: GO:0090043
term: regulation of tubulin deacetylation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid.


go_id: GO:0090044
term: positive regulation of tubulin deacetylation
ontology: BP
definition:
Any process that increases the frequency, rate or extent of tubulin deacetylation. Tubulin deacetylation is the removal of an acetyl group from a protein amino acid.


go_id: GO:0090045
term: positive regulation of deacetylase activity
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of deacetylase activity, the catalysis of the hydrolysis of an acetyl group or groups from a substrate molecule.


go_id: GO:0090049
term: regulation of cell migration involved in sprouting angiogenesis
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.


go_id: GO:0090050
term: positive regulation of cell migration involved in sprouting angiogenesis
ontology: BP
definition:
Any process that increases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.


go_id: GO:0090051
term: negative regulation of cell migration involved in sprouting angiogenesis
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of cell migration involved in sprouting angiogenesis. Cell migration involved in sprouting angiogenesis is the orderly movement of endothelial cells into the extracellular matrix in order to form new blood vessels contributing to the process of sprouting angiogenesis.


go_id: GO:0090052
term: regulation of pericentric heterochromatin formation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of heterochromatin formation at the centromere. Chromatin silencing at the centromere is the repression of transcription of centromeric DNA by altering the structure of chromatin.


go_id: GO:0090054
term: regulation of silent mating-type cassette heterochromatin formation
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of heterochromatin formation at silent mating-type cassette.


go_id: GO:0090055
term: positive regulation of silent mating-type cassette heterochromatin formation
ontology: BP
definition:
Any process that increases the frequency, rate, or extent of heterochromatin formation at silent mating-type cassette.


go_id: GO:0090056
term: regulation of chlorophyll metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving chlorophyll.


go_id: GO:0090057
term: root radial pattern formation
ontology: BP
definition:
The radial pattern formation process that results in the formation of the different tissues of the root around its radial axis.


go_id: GO:0090058
term: metaxylem development
ontology: BP
definition:
The process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed.


go_id: GO:0090059
term: protoxylem development
ontology: BP
definition:
The process whose specific outcome is the progression of the protoxylem over time, from its formation to the mature structure. The protoxylem comprises the first formed elements of the primary xylem.


go_id: GO:0090060
term: regulation of metaxylem development
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of metaxylem development. Metaxylem development is the process whose specific outcome is the progression of the metaxylem over time, from its formation to the mature structure. The metaxylem is the part of the primary xylem that differentiates after the protoxylem and before the secondary xylem, if any of the latter is formed.


go_id: GO:0090062
term: regulation of trehalose metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of trehalose metabolism, the chemical reactions and pathways involving trehalose, a disaccharide isomeric with sucrose and obtained from certain lichens and fungi.


go_id: GO:0090063
term: positive regulation of microtubule nucleation
ontology: BP
definition:
Any process that increases the rate, frequency or extent of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.


go_id: GO:0090064
term: activation of microtubule nucleation
ontology: BP
definition:
Any process that starts the inactive process of microtubule nucleation. Microtubule nucleation is the 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates, some of which go on to support formation of a complete microtubule. Microtubule nucleation usually occurs from a specific site within a cell.


go_id: GO:0090067
term: regulation of thalamus size
ontology: BP
definition:
Any process that modulates the size of the thalamus. The thalamus is a part of the diencephalon that is composed of the dorsal thalamus and the ventral thalamus.


go_id: GO:0090068
term: positive regulation of cell cycle process
ontology: BP
definition:
Any process that increases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.


go_id: GO:0090069
term: regulation of ribosome biogenesis
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.


go_id: GO:0090070
term: positive regulation of ribosome biogenesis
ontology: BP
definition:
Any process that increases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.


go_id: GO:0090071
term: negative regulation of ribosome biogenesis
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of ribosome biogenesis. Ribosome biogenesis is the cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of ribosome subunits.


go_id: GO:0090073
term: positive regulation of protein homodimerization activity
ontology: BP
definition:
Any process that increases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.


go_id: GO:0090074
term: negative regulation of protein homodimerization activity
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of protein homodimerization, interacting selectively with an identical protein to form a homodimer.


go_id: GO:0090075
term: relaxation of muscle
ontology: BP
definition:
A process in which the extent of muscle contraction is reduced. Muscle relaxation can involve a number of processes including the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases. In some muscles, calcium-independent pathways also play a role in muscle relaxation by decreasing the phosphorylation state of myosin light chain.


go_id: GO:0090076
term: relaxation of skeletal muscle
ontology: BP
definition:
A process in which the extent of skeletal muscle tissue contraction is reduced. Muscle relaxation involves the removal of calcium from the cytoplasm to the sarcoplasmic reticulum lumen through the action of Ca2+ ATPases.


go_id: GO:0090077
term: foam cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.


go_id: GO:0090078
term: smooth muscle derived foam cell differentiation
ontology: BP
definition:
The process in which a smooth muscle cell acquires the specialized features of a foam cell. A foam cell is a type of cell containing lipids in small vacuoles and typically seen in atherosclerotic lesions, as well as other conditions.


go_id: GO:0090079
term: translation regulator activity, nucleic acid binding
ontology: MF
definition:
Any selective and non-covalent interaction with a nucleic acid involved in the initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome.


go_id: GO:0090080
term: positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway
ontology: BP
definition:
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands resulting in an increase in the rate or frequency of a MAPKKK cascade.


go_id: GO:0090081
term: regulation of heart induction by regulation of canonical Wnt signaling pathway
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of canonical Wnt signaling pathway that regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell, followed by relaying of the signal via beta-catenin, and ending with a change in transcription of target genes.


go_id: GO:0090082
term: positive regulation of heart induction by negative regulation of canonical Wnt signaling pathway
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of canonical Wnt signaling pathway that positively regulates heart induction. Canonical Wnt signaling pathway involved in heart induction is the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.


go_id: GO:0090083
term: regulation of inclusion body assembly
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body.


go_id: GO:0090084
term: negative regulation of inclusion body assembly
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body.


go_id: GO:0090085
term: regulation of protein deubiquitination
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein.


go_id: GO:0090086
term: negative regulation of protein deubiquitination
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of protein deubiquitination. Protein deubiquitination is the removal of one or more ubiquitin groups from a protein.


go_id: GO:0090087
term: regulation of peptide transport
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0090088
term: regulation of oligopeptide transport
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the directed movement of oligopeptides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


go_id: GO:0090089
term: regulation of dipeptide transport
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of dipeptide transport. Dipeptide transport is the directed movement of a dipeptide, a combination of two amino acids by means of a peptide (-CO-NH-) link, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0090090
term: negative regulation of canonical Wnt signaling pathway
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.


go_id: GO:0090091
term: positive regulation of extracellular matrix disassembly
ontology: BP
definition:
Any process that increases the rate, frequency or extent of extracellular matrix disassembly. Extracellular matrix disassembly is a process that results in the breakdown of the extracellular matrix.


go_id: GO:0090092
term: regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.


go_id: GO:0090093
term: regulation of fungal-type cell wall beta-glucan biosynthetic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of fungal-type cell wall beta-glucan biosynthesis, the chemical reactions and pathways resulting in the formation of beta-glucans, compounds composed of glucose residues linked by beta-D-glucosidic bonds, found in the walls of fungal cells.


go_id: GO:0090094
term: metanephric cap mesenchymal cell proliferation involved in metanephros development
ontology: BP
definition:
The multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip.


go_id: GO:0090095
term: regulation of metanephric cap mesenchymal cell proliferation
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip.


go_id: GO:0090096
term: positive regulation of metanephric cap mesenchymal cell proliferation
ontology: BP
definition:
Any process that increases the frequency, rate, or extent of metanephric cap mesenchymal cell proliferation. Metanephric cap mesenchymal cell proliferation is the multiplication or reproduction of metanephric cap mesenchymal cells, resulting in the expansion of the cell population. A metanephric cap mesenchymal cell is a mesenchymal cell that has condensed with other mesenchymal cells surrounding the ureteric bud tip.


go_id: GO:0090100
term: positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.


go_id: GO:0090101
term: negative regulation of transmembrane receptor protein serine/threonine kinase signaling pathway
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of the series of molecular signals generated as a consequence of a transmembrane receptor serine/threonine kinase binding to its physiological ligand.


go_id: GO:0090102
term: cochlea development
ontology: BP
definition:
The progression of the cochlea over time from its formation to the mature structure. The cochlea is the snail-shaped portion of the inner ear that is responsible for the detection of sound.


go_id: GO:0090104
term: pancreatic epsilon cell differentiation
ontology: BP
definition:
The process in which relatively unspecialized cells acquire specialized structural and functional features of a pancreatic epsilon cell. A pancreatic epsilon cell is a cell in the pancreas that secretes ghrelin.


go_id: GO:0090105
term: pancreatic E cell development
ontology: BP
definition:
The process whose specific outcome is the progression of a pancreatic E cell over time, from its formation to the mature structure.


go_id: GO:0090106
term: pancreatic E cell fate commitment
ontology: BP
definition:
The commitment of a cell to a pancreatic E cell fate and its capacity to differentiate into a pancreatic E cell.


go_id: GO:0090107
term: regulation of high-density lipoprotein particle assembly
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.


go_id: GO:0090108
term: positive regulation of high-density lipoprotein particle assembly
ontology: BP
definition:
Any process that increases the frequency, rate, or extent of high-density lipoprotein particle assembly. High-density lipoprotein particle assembly is the aggregation and arrangement of proteins and lipids to form a high-density lipoprotein particle.


go_id: GO:0090109
term: regulation of cell-substrate junction assembly
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of cell-substrate junction assembly. Cell-substrate junction assembly is the aggregation, arrangement and bonding together of a set of components to form a junction between a cell and its substrate.


go_id: GO:0090110
term: COPII-coated vesicle cargo loading
ontology: BP
definition:
The formation of a macromolecular complex between the COPII coat proteins and proteins and/or lipoproteins that are going to be transported by the COPII vesicle to the Golgi.


go_id: GO:0090111
term: regulation of COPII vesicle uncoating
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of COPII vesicle uncoating, the process in which COPII vesicle coat proteins are disassembled, and released.


go_id: GO:0090113
term: regulation of ER to Golgi vesicle-mediated transport by GTP hydrolysis
ontology: BP
definition:
The GTP hydrolysis process that modulates the rate, frequency, or extent of ER to Golgi vesicle-mediated transport, the directed movement of substances from the endoplasmic reticulum (ER) to the Golgi, mediated by COP II vesicles.


go_id: GO:0090114
term: COPII-coated vesicle budding
ontology: BP
definition:
The evagination of an endoplasmic reticulum membrane, resulting in formation of a COPII-coated vesicle.


go_id: GO:0090119
term: vesicle-mediated cholesterol transport
ontology: BP
definition:
The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, by membrane-bounded vesicles.


go_id: GO:0090120
term: lysosome to ER cholesterol transport
ontology: BP
definition:
The directed movement of cholesterol, cholest-5-en-3-beta-ol, or cholesterol-containing compounds, from the lysosome to the endoplasmic reticulum.


go_id: GO:0090121
term: low-density lipoprotein particle disassembly involved in cholesterol transport
ontology: BP
definition:
The disassembly into constituent parts of the low-density lipoprotein particle in the lysosome that contributes to cholesterol transport.


go_id: GO:0090122
term: cholesterol ester hydrolysis involved in cholesterol transport
ontology: BP
definition:
The cholesterol metabolic process in which cholesterol esters are hydrolyzed into free fatty acids and cholesterol in the lysosome that contributes to intracellular cholesterol transport.


go_id: GO:0090123
term: lysosomal glycocalyx
ontology: CC
definition:
The polysaccharide-based coating on the inner side of a lysosomal membrane. It may be involved in protecting the membrane from digestion by lysosomal enzymes.


go_id: GO:0090125
term: cell-cell adhesion involved in synapse maturation
ontology: BP
definition:
The attachment of the pre-synaptic cell to the post-synaptic cell via adhesion molecules that contributes to synapse maturation.


go_id: GO:0090126
term: protein-containing complex assembly involved in synapse maturation
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a protein complex that contributes to synapse maturation.


go_id: GO:0090127
term: positive regulation of synapse maturation by synaptic transmission
ontology: BP
definition:
Any process that increases the extent of synaptic maturation as a result of the communication from a pre-synaptic cell to a post-synaptic cell across a synapse.


go_id: GO:0090128
term: regulation of synapse maturation
ontology: BP
definition:
Any process that modulates the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.


go_id: GO:0090129
term: positive regulation of synapse maturation
ontology: BP
definition:
Any process that increases the extent of synapse maturation, the process that organizes a synapse so that it attains its fully functional state.


go_id: GO:0090133
term: mesendoderm migration
ontology: BP
definition:
The process in which the population of cells that make up a mesendoderm undergo directed movement. The mesendoderm is the epithelial tissue that gives rise to both mesoderm and endoderm.


go_id: GO:0090134
term: cell migration involved in mesendoderm migration
ontology: BP
definition:
The orderly movement of epithelial cells from one site to another that contributes to the migration of mesendodermal tissue.


go_id: GO:0090135
term: actin filament branching
ontology: BP
definition:
The formation of daughter actin filament branches at an angle on the sides of preexisting mother filaments.


go_id: GO:0090137
term: epithelial cell-cell adhesion involved in epithelium migration
ontology: BP
definition:
The attachment of an epithelial cell to another epithelial cell via adhesion molecules that contributes to epithelium migration.


go_id: GO:0090138
term: regulation of actin cytoskeleton organization by cell-cell adhesion
ontology: BP
definition:
Any cell-cell adhesion process that modulates the formation, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising actin filaments and their associated proteins.


go_id: GO:0090139
term: mitochondrial chromosome packaging
ontology: BP
definition:
A process in which mitochondrial chromosomal DNA and associated proteins organize into a compact, orderly structure.


go_id: GO:0090140
term: regulation of mitochondrial fission
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.


go_id: GO:0090141
term: positive regulation of mitochondrial fission
ontology: BP
definition:
Any process that increases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.


go_id: GO:0090143
term: nucleoid organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the nucleoid. The nucleoid is the region of a bacterial cell, virion, mitochondrion or chloroplast to which the DNA is confined.


go_id: GO:0090144
term: mitochondrial nucleoid organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the mitochondrial nucleoid. The mitochondrial nucleoid is the region of a mitochondrion to which the DNA is confined.


go_id: GO:0090148
term: membrane fission
ontology: BP
definition:
A process that is carried out at the cellular level which results in the separation of a single continuous membrane into two membranes.


go_id: GO:0090149
term: mitochondrial membrane fission
ontology: BP
definition:
A process that is carried out at the cellular level which results in the separation of a single continuous mitochondrial membrane into two membranes and contributes to mitochondrial fission.


go_id: GO:0090152
term: establishment of protein localization to mitochondrial membrane involved in mitochondrial fission
ontology: BP
definition:
The directed movement of a protein to a specific location in the mitochondrial membrane that contributes to mitochondrial fission.


go_id: GO:0090153
term: regulation of sphingolipid biosynthetic process
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


go_id: GO:0090154
term: positive regulation of sphingolipid biosynthetic process
ontology: BP
definition:
Any process that increases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


go_id: GO:0090155
term: negative regulation of sphingolipid biosynthetic process
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of sphingolipid biosynthesis. Sphingolipid biosynthesis is the chemical reactions and pathways resulting in the formation of sphingolipids, any of a class of lipids containing the long-chain amine diol sphingosine or a closely related base (a sphingoid).


go_id: GO:0090156
term: cellular sphingolipid homeostasis
ontology: BP
definition:
Any biological process involved in the maintenance of an internal steady state of sphingolipids at the level of the cell.


go_id: GO:0090158
term: endoplasmic reticulum membrane organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of an endoplasmic reticulum membrane.


go_id: GO:0090159
term: sphingolipid biosynthesis involved in endoplasmic reticulum membrane organization
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of sphingolipids that contributes to endoplasmic reticulum membrane organization.


go_id: GO:0090163
term: establishment of epithelial cell planar polarity
ontology: BP
definition:
The specification and formation of the polarity of an epithelial cell along the plane of the epithelial tissue.


go_id: GO:0090164
term: asymmetric Golgi ribbon formation
ontology: BP
definition:
The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that contributes to the establishment of epithelial cell polarity.


go_id: GO:0090165
term: regulation of secretion by asymmetric Golgi ribbon formation
ontology: BP
definition:
The asymmetric formation of a continuous ribbon of interconnected Golgi stacks of flat cisternae that modulates the controlled release of a substance from a polarized epithelial cell.


go_id: GO:0090166
term: Golgi disassembly
ontology: BP
definition:
A cellular process that results in the breakdown of a Golgi apparatus that contributes to Golgi inheritance.


go_id: GO:0090167
term: Golgi distribution to daughter cells
ontology: BP
definition:
Any process in which disassembled Golgi vesicles are localized into daughter cells upon cell division.


go_id: GO:0090168
term: Golgi reassembly
ontology: BP
definition:
The reformation of the Golgi following its breakdown and partitioning contributing to Golgi inheritance.


go_id: GO:0090169
term: regulation of spindle assembly
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of spindle assembly. Spindle assembly is the aggregation, arrangement and bonding together of a set of components to form the spindle, the array of microtubules and associated molecules that serves to move duplicated chromosomes apart.


go_id: GO:0090170
term: regulation of Golgi inheritance
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of Golgi inheritance. Golgi inheritance is the partitioning of Golgi apparatus between daughter cells at cell division.


go_id: GO:0090171
term: chondrocyte morphogenesis
ontology: BP
definition:
The process in which the structures of a chondrocyte are generated and organized. This process occurs while the initially relatively unspecialized cell is acquiring the specialized features of a chondrocyte.


go_id: GO:0090172
term: microtubule cytoskeleton organization involved in homologous chromosome segregation
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins that contributes to chromosomal pairing and precedes synapsis.


go_id: GO:0090173
term: regulation of synaptonemal complex assembly
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of synaptonemal complex assembly. Synaptonemal complex assembly is the cell cycle process in which the synaptonemal complex, a structure that holds paired chromosomes together during prophase I of meiosis and that promotes genetic recombination, is formed.


go_id: GO:0090175
term: regulation of establishment of planar polarity
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of the establishment of planar polarity, the coordinated organization of groups of cells in a tissue, such that they all orient to similar coordinates.


go_id: GO:0090176
term: microtubule cytoskeleton organization involved in establishment of planar polarity
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of cytoskeletal structures comprising microtubules and their associated proteins and contributes to the establishment of planar polarity.


go_id: GO:0090177
term: establishment of planar polarity involved in neural tube closure
ontology: BP
definition:
Coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube.


go_id: GO:0090178
term: regulation of establishment of planar polarity involved in neural tube closure
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the establishment of planar polarity involved in neural tube closure, the coordinated organization of groups of cells in the plane of an epithelium that contributes to the closure of the neural tube.


go_id: GO:0090179
term: planar cell polarity pathway involved in neural tube closure
ontology: BP
definition:
The series of molecular signals initiated by binding of a Wnt protein to a receptor on the surface of the target cell where activated receptors signal via downstream effectors that modulates the establishment of planar polarity contributing to neural tube closure.


go_id: GO:0090180
term: positive regulation of thiamine biosynthetic process
ontology: BP
definition:
Any process that increases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of thiamine.


go_id: GO:0090181
term: regulation of cholesterol metabolic process
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


go_id: GO:0090182
term: regulation of secretion of lysosomal enzymes
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell.


go_id: GO:0090183
term: regulation of kidney development
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.


go_id: GO:0090184
term: positive regulation of kidney development
ontology: BP
definition:
Any process that increases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.


go_id: GO:0090185
term: negative regulation of kidney development
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of kidney development. Kidney development is the process whose specific outcome is the progression of the kidney over time, from its formation to the mature structure. The kidney is an organ that filters the blood and excretes the end products of body metabolism in the form of urine.


go_id: GO:0090186
term: regulation of pancreatic juice secretion
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine.


go_id: GO:0090187
term: positive regulation of pancreatic juice secretion
ontology: BP
definition:
Any process that increases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine.


go_id: GO:0090188
term: negative regulation of pancreatic juice secretion
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of pancreatic juice secretion, the regulated release of pancreatic juice by the exocrine pancreas into the upper part of the intestine.


go_id: GO:0090189
term: regulation of branching involved in ureteric bud morphogenesis
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.


go_id: GO:0090190
term: positive regulation of branching involved in ureteric bud morphogenesis
ontology: BP
definition:
Any process that increases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.


go_id: GO:0090191
term: negative regulation of branching involved in ureteric bud morphogenesis
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of branching involved in ureteric bud morphogenesis, the process in which the branching structure of the ureteric bud is generated and organized. The ureteric bud is an epithelial tube that grows out from the metanephric duct. The bud elongates and branches to give rise to the ureter and kidney collecting tubules.


go_id: GO:0090192
term: regulation of glomerulus development
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.


go_id: GO:0090193
term: positive regulation of glomerulus development
ontology: BP
definition:
Any process that increases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.


go_id: GO:0090194
term: negative regulation of glomerulus development
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of glomerulus development, the progression of the glomerulus over time from its initial formation until its mature state. The glomerulus is a capillary tuft surrounded by Bowman's capsule in nephrons of the vertebrate kidney.


go_id: GO:0090199
term: regulation of release of cytochrome c from mitochondria
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.


go_id: GO:0090200
term: positive regulation of release of cytochrome c from mitochondria
ontology: BP
definition:
Any process that increases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.


go_id: GO:0090201
term: negative regulation of release of cytochrome c from mitochondria
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of release of cytochrome c from mitochondria, the process in which cytochrome c is enabled to move from the mitochondrial intermembrane space into the cytosol, which is an early step in apoptosis and leads to caspase activation.


go_id: GO:0090205
term: positive regulation of cholesterol metabolic process
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


go_id: GO:0090206
term: negative regulation of cholesterol metabolic process
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of cholesterol metabolism, the chemical reactions and pathways involving cholesterol, cholest-5-en-3 beta-ol, the principal sterol of vertebrates and the precursor of many steroids, including bile acids and steroid hormones.


go_id: GO:0090207
term: regulation of triglyceride metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol.


go_id: GO:0090208
term: positive regulation of triglyceride metabolic process
ontology: BP
definition:
Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol.


go_id: GO:0090209
term: negative regulation of triglyceride metabolic process
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving triglyceride, any triester of glycerol.


go_id: GO:0090210
term: regulation of establishment of blood-brain barrier
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain.


go_id: GO:0090211
term: positive regulation of establishment of blood-brain barrier
ontology: BP
definition:
Any process that increases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain.


go_id: GO:0090212
term: negative regulation of establishment of blood-brain barrier
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of the establishment of the blood-brain barrier, a selectively permeable structural and functional barrier that exists between the capillaries and the brain.


go_id: GO:0090213
term: regulation of radial pattern formation
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of radial pattern formation, the regionalization process that results in defined areas around a point in which specific types of cell differentiation will occur.


go_id: GO:0090214
term: spongiotrophoblast layer developmental growth
ontology: BP
definition:
The increase in size or mass of the spongiotrophoblast layer of the placenta where the increase in size or mass contributes to the progression of that layer over time from its formation to its mature state.


go_id: GO:0090215
term: regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.


go_id: GO:0090216
term: positive regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
ontology: BP
definition:
Any process that increases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.


go_id: GO:0090217
term: negative regulation of 1-phosphatidylinositol-4-phosphate 5-kinase activity
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of the catalysis of the reaction: ATP + 1-phosphatidyl-1D-myo-inositol 4-phosphate = ADP + 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.


go_id: GO:0090218
term: positive regulation of lipid kinase activity
ontology: BP
definition:
Any process that increases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid.


go_id: GO:0090219
term: negative regulation of lipid kinase activity
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of lipid kinase activity, the catalysis of the transfer of a phosphate group, usually from ATP, to a simple or complex lipid.


go_id: GO:0090220
term: chromosome localization to nuclear envelope involved in homologous chromosome segregation
ontology: BP
definition:
The directed movement of a chromosome to the nuclear envelope that contributes to homologous chromosome segregation and precedes synapsis.


go_id: GO:0090221
term: mitotic spindle-templated microtubule nucleation
ontology: BP
definition:
The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from within the mitotic spindle.


go_id: GO:0090222
term: centrosome-templated microtubule nucleation
ontology: BP
definition:
The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from the centrosome.


go_id: GO:0090223
term: chromatin-templated microtubule nucleation
ontology: BP
definition:
The 'de novo' formation of a microtubule, in which tubulin heterodimers form metastable oligomeric aggregates from chromatin.


go_id: GO:0090224
term: regulation of spindle organization
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of the assembly, arrangement of constituent parts, or disassembly of the microtubule spindle.


go_id: GO:0090226
term: regulation of microtubule nucleation by Ran protein signal transduction
ontology: BP
definition:
The series of molecular signals in which a Ran GTPase relays a signal resulting in the modulation of the rate, frequency or extent of microtubule nucleation.


go_id: GO:0090227
term: regulation of red or far-red light signaling pathway
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light.


go_id: GO:0090228
term: positive regulation of red or far-red light signaling pathway
ontology: BP
definition:
Any process that increases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light.


go_id: GO:0090229
term: negative regulation of red or far-red light signaling pathway
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of the red or far-red signaling pathway, the series of molecular signals initiated upon sensing by photoreceptor molecules of red light or far red light.


go_id: GO:0090230
term: regulation of centromere complex assembly
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of centromere complex assembly, the aggregation, arrangement and bonding together of proteins and centromeric DNA molecules to form a centromeric protein-DNA complex.


go_id: GO:0090231
term: regulation of spindle checkpoint
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.


go_id: GO:0090232
term: positive regulation of spindle checkpoint
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.


go_id: GO:0090233
term: negative regulation of spindle checkpoint
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of the spindle checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition until the spindle is correctly assembled and oriented, and chromosomes are attached to the spindle.


go_id: GO:0090234
term: regulation of kinetochore assembly
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of kinetochore assembly, the aggregation, arrangement and bonding together of a set of components to form the kinetochore, a multisubunit complex that is located at the centromeric region of DNA and provides an attachment point for the spindle microtubules.


go_id: GO:0090235
term: regulation of metaphase plate congression
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of metaphase plate congression, the alignment of chromosomes at the metaphase plate, a plane halfway between the poles of the spindle.


go_id: GO:0090237
term: regulation of arachidonic acid secretion
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue.


go_id: GO:0090238
term: positive regulation of arachidonic acid secretion
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of arachidonic acid secretion, the controlled release of arachidonic acid from a cell or a tissue.


go_id: GO:0090239
term: regulation of histone H4 acetylation
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group.


go_id: GO:0090240
term: positive regulation of histone H4 acetylation
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group.


go_id: GO:0090241
term: negative regulation of histone H4 acetylation
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of histone H4 acetylation, the modification of histone H4 by the addition of an acetyl group.


go_id: GO:0090242
term: retinoic acid receptor signaling pathway involved in somitogenesis
ontology: BP
definition:
The series of molecular signals generated as a consequence of a retinoic acid receptor binding to one of its physiological ligands that contributes to somitogenesis.


go_id: GO:0090243
term: fibroblast growth factor receptor signaling pathway involved in somitogenesis
ontology: BP
definition:
The series of molecular signals generated as a consequence of a fibroblast growth factor receptor binding to one of its physiological ligands that contributes to somitogenesis.


go_id: GO:0090244
term: Wnt signaling pathway involved in somitogenesis
ontology: BP
definition:
The series of molecular signals initiated by binding of Wnt protein to a frizzled family receptor on the surface of the target cell and ending with a change in cell state that contributes to somitogenesis.


go_id: GO:0090245
term: axis elongation involved in somitogenesis
ontology: BP
definition:
The developmental growth that results in the elongation of the rostral-caudal axis that contributes to somitogenesis.


go_id: GO:0090246
term: convergent extension involved in somitogenesis
ontology: BP
definition:
The morphogenetic process in which a presomitic mesoderm narrows along the left-right axis and lengthens in the rostral-caudal axis contributing to somitogenesis.


go_id: GO:0090248
term: cell migration involved in somitogenic axis elongation
ontology: BP
definition:
Any process involved in the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation.


go_id: GO:0090249
term: regulation of cell migration involved in somitogenic axis elongation
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of the controlled self-propelled movement of a cell that contributes to somitogenic axis elongation.


go_id: GO:0090250
term: cell-cell adhesion involved in establishment of planar polarity
ontology: BP
definition:
The attachment of one cell to another cell via adhesion molecules that contributes to the establishment of planar cell polarity.


go_id: GO:0090251
term: protein localization involved in establishment of planar polarity
ontology: BP
definition:
Any process in which a protein is transported to, and/or maintained in, a specific location in a cell that contributes to the establishment of planar polarity.


go_id: GO:0090252
term: epithelium migration involved in imaginal disc-derived wing morphogenesis
ontology: BP
definition:
The process in which the population of cells that make up a wing epithelium undergo directed movement and contribute to imaginal disc-derived morphogenesis.


go_id: GO:0090253
term: convergent extension involved in imaginal disc-derived wing morphogenesis
ontology: BP
definition:
The morphogenetic process in which the wing epithelium narrows along one axis and lengthens in a perpendicular axis that contributes to imaginal disc-derived wing morphogenesis.


go_id: GO:0090255
term: cell proliferation involved in imaginal disc-derived wing morphogenesis
ontology: BP
definition:
The multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis.


go_id: GO:0090256
term: regulation of cell proliferation involved in imaginal disc-derived wing morphogenesis
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of the multiplication or reproduction of cells, resulting in the expansion of a cell population that contributes to imaginal disc-derived wing morphogenesis.


go_id: GO:0090257
term: regulation of muscle system process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of a muscle system process, a multicellular organismal process carried out by any of the organs or tissues in a muscle system.


go_id: GO:0090258
term: negative regulation of mitochondrial fission
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of mitochondrial fission. Mitochondrial fission is the division of a mitochondrion within a cell to form two or more separate mitochondrial compartments.


go_id: GO:0090259
term: regulation of retinal ganglion cell axon guidance
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.


go_id: GO:0090260
term: negative regulation of retinal ganglion cell axon guidance
ontology: BP
definition:
Any process that decreases the frequency, rate, or extent of retinal ganglion cell axon guidance, the process in which the migration of an axon growth cone of a retinal ganglion cell (RGC) is directed to its target in the brain in response to a combination of attractive and repulsive cues.


go_id: GO:0090261
term: positive regulation of inclusion body assembly
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of inclusion body assembly. Inclusion body assembly is the aggregation, arrangement and bonding together of a set of components to form an inclusion body.


go_id: GO:0090262
term: regulation of transcription-coupled nucleotide-excision repair
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of the nucleotide-excision repair process that carries out preferential repair of DNA lesions on the actively transcribed strand of the DNA duplex. In addition, the transcription-coupled nucleotide-excision repair pathway is required for the recognition and repair of a small subset of lesions that are not recognized by the global genome nucleotide excision repair pathway.


go_id: GO:0090263
term: positive regulation of canonical Wnt signaling pathway
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of the Wnt signaling pathway through beta-catenin, the series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes.


go_id: GO:0090264
term: regulation of immune complex clearance by monocytes and macrophages
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages.


go_id: GO:0090265
term: positive regulation of immune complex clearance by monocytes and macrophages
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of the process of immune complex clearance by monocytes or macrophages.


go_id: GO:0090266
term: regulation of mitotic cell cycle spindle assembly checkpoint
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.


go_id: GO:0090267
term: positive regulation of mitotic cell cycle spindle assembly checkpoint
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of the mitotic cell cycle spindle assembly checkpoint, a cell cycle checkpoint that delays the metaphase/anaphase transition of a mitotic nuclear division until the spindle is correctly assembled and chromosomes are attached to the spindle.


go_id: GO:0090269
term: fibroblast growth factor production
ontology: BP
definition:
The appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0090270
term: regulation of fibroblast growth factor production
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0090271
term: positive regulation of fibroblast growth factor production
ontology: BP
definition:
Any process that increases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0090272
term: negative regulation of fibroblast growth factor production
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of the appearance of a fibroblast growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0090273
term: regulation of somatostatin secretion
ontology: BP
definition:
Any process that modulates the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.


go_id: GO:0090274
term: positive regulation of somatostatin secretion
ontology: BP
definition:
Any process that increases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.


go_id: GO:0090275
term: negative regulation of somatostatin secretion
ontology: BP
definition:
Any process that decreases the rate, frequency, extent of the regulated release of somatostatin from secretory granules in the D cells of the pancreas.


go_id: GO:0090276
term: regulation of peptide hormone secretion
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.


go_id: GO:0090277
term: positive regulation of peptide hormone secretion
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.


go_id: GO:0090278
term: negative regulation of peptide hormone secretion
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of the regulated release of a peptide hormone from secretory granules.


go_id: GO:0090279
term: regulation of calcium ion import
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.


go_id: GO:0090280
term: positive regulation of calcium ion import
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.


go_id: GO:0090281
term: negative regulation of calcium ion import
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of the directed movement of calcium ions into a cell or organelle.


go_id: GO:0090282
term: positive regulation of transcription involved in G2/M transition of mitotic cell cycle
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle.


go_id: GO:0090287
term: regulation of cellular response to growth factor stimulus
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.


go_id: GO:0090288
term: negative regulation of cellular response to growth factor stimulus
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a growth factor stimulus.


go_id: GO:0090289
term: regulation of osteoclast proliferation
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.


go_id: GO:0090290
term: positive regulation of osteoclast proliferation
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.


go_id: GO:0090291
term: negative regulation of osteoclast proliferation
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of the multiplication or reproduction of osteoclasts, resulting in the expansion of an osteoclast cell population.


go_id: GO:0090292
term: nuclear matrix anchoring at nuclear membrane
ontology: BP
definition:
The process in which the nuclear matrix, the dense fibrillar network lying on the inner side of the nuclear membrane, is directly or indirectly linked to the nuclear membrane.


go_id: GO:0090293
term: nitrogen catabolite regulation of transcription
ontology: BP
definition:
A transcription regulation process in which the presence of one nitrogen source leads to the modulation of the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.


go_id: GO:0090294
term: nitrogen catabolite activation of transcription
ontology: BP
definition:
A transcription regulation process in which the presence of one nitrogen source leads to an increase in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.


go_id: GO:0090295
term: nitrogen catabolite repression of transcription
ontology: BP
definition:
A transcription regulation process in which the presence of one nitrogen source leads to a decrease in the frequency, rate, or extent of transcription of specific genes involved in the metabolism of other nitrogen sources.


go_id: GO:0090296
term: regulation of mitochondrial DNA replication
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion.


go_id: GO:0090297
term: positive regulation of mitochondrial DNA replication
ontology: BP
definition:
Any process that increases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion.


go_id: GO:0090298
term: negative regulation of mitochondrial DNA replication
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of the process in which new strands of DNA are synthesized in the mitochondrion.


go_id: GO:0090299
term: regulation of neural crest formation
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation proceeds.


go_id: GO:0090300
term: positive regulation of neural crest formation
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.


go_id: GO:0090301
term: negative regulation of neural crest formation
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of neural crest formation. Neural crest formation is the formation of the specialized region of ectoderm between the neural ectoderm (neural plate) and non-neural ectoderm. The neural crest gives rise to the neural crest cells that migrate away from this region as neural tube formation procedes.


go_id: GO:0090303
term: positive regulation of wound healing
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of the series of events that restore integrity to a damaged tissue, following an injury.


go_id: GO:0090305
term: nucleic acid phosphodiester bond hydrolysis
ontology: BP
definition:
The nucleic acid metabolic process in which the phosphodiester bonds between nucleotides are cleaved by hydrolysis.


go_id: GO:0090306
term: meiotic spindle assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form the spindle that contributes to the process of meiosis.


go_id: GO:0090307
term: mitotic spindle assembly
ontology: BP
definition:
Mitotic bipolar spindle assembly begins with spindle microtubule nucleation from the separated spindle pole body, includes spindle elongation during prometaphase, and is complete when all kinetochores are stably attached the spindle, and the spindle assembly checkpoint is satisfied.


go_id: GO:0090308
term: regulation of DNA methylation-dependent heterochromatin formation
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation.


go_id: GO:0090309
term: positive regulation of DNA methylation-dependent heterochromatin formation
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation.


go_id: GO:0090310
term: negative regulation of DNA methylation-dependent heterochromatin formation
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of DNA methylation-dependent heterochromatin formation.


go_id: GO:0090311
term: regulation of protein deacetylation
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.


go_id: GO:0090312
term: positive regulation of protein deacetylation
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of protein deacetylation, the removal of an acetyl group from a protein amino acid. An acetyl group is CH3CO-, derived from acetic [ethanoic] acid.


go_id: GO:0090313
term: regulation of protein targeting to membrane
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.


go_id: GO:0090314
term: positive regulation of protein targeting to membrane
ontology: BP
definition:
Any process that increases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.


go_id: GO:0090315
term: negative regulation of protein targeting to membrane
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.


go_id: GO:0090316
term: positive regulation of intracellular protein transport
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of the directed movement of proteins within cells.


go_id: GO:0090317
term: negative regulation of intracellular protein transport
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of the directed movement of proteins within cells.


go_id: GO:0090318
term: regulation of chylomicron remodeling
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid.


go_id: GO:0090319
term: positive regulation of chylomicron remodeling
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of chylomicron remodeling. Chylomicron remodeling is the acquisition, loss or modification of a protein or lipid within a chylomicron, including the hydrolysis of triglyceride by lipoprotein lipase and the subsequent loss of free fatty acid.


go_id: GO:0090320
term: regulation of chylomicron remnant clearance
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded.


go_id: GO:0090321
term: positive regulation of chylomicron remnant clearance
ontology: BP
definition:
Any process that increases the rate, frequency or extent of chylomicron remnant clearance. Chylomicron clearance is the process in which a chylomicron remnant is removed from the blood via receptor-mediated endocytosis into liver cells and its constituent parts degraded.


go_id: GO:0090322
term: regulation of superoxide metabolic process
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of superoxide metabolism, the chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species.


go_id: GO:0090323
term: prostaglandin secretion involved in immune response
ontology: BP
definition:
The regulated release of a prostaglandin that contributes to the immune response. Prostaglandins are a group of biologically active metabolites which contain a cyclopentane ring.


go_id: GO:0090324
term: negative regulation of oxidative phosphorylation
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the phosphorylation of ADP to ATP that accompanies the oxidation of a metabolite through the operation of the respiratory chain. Oxidation of compounds establishes a proton gradient across the membrane, providing the energy for ATP synthesis.


go_id: GO:0090325
term: regulation of locomotion involved in locomotory behavior
ontology: BP
definition:
Any process that modulates the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.


go_id: GO:0090326
term: positive regulation of locomotion involved in locomotory behavior
ontology: BP
definition:
Any process that increases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.


go_id: GO:0090327
term: negative regulation of locomotion involved in locomotory behavior
ontology: BP
definition:
Any process that decreases the frequency, rate, or extent of the self-propelled movement of a cell or organism from one location to another in a behavioral context; the aspect of locomotory behavior having to do with movement.


go_id: GO:0090328
term: regulation of olfactory learning
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of olfactory learning. Olfactory learning is any process in an organism in which a relatively long-lasting adaptive behavioral change occurs in response to (repeated) exposure to an olfactory cue.


go_id: GO:0090329
term: regulation of DNA-templated DNA replication
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of DNA-templated DNA replication, the process in which new strands of DNA are synthesized.


go_id: GO:0090330
term: regulation of platelet aggregation
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.


go_id: GO:0090331
term: negative regulation of platelet aggregation
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of platelet aggregation. Platelet aggregation is the adhesion of one platelet to one or more other platelets via adhesion molecules.


go_id: GO:0090332
term: stomatal closure
ontology: BP
definition:
The process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange.


go_id: GO:0090333
term: regulation of stomatal closure
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of stomatal closure. Stomatal closure is the process of closing of stomata, pores in the epidermis of leaves and stems bordered by two guard cells and serving in gas exchange.


go_id: GO:0090334
term: regulation of cell wall (1->3)-beta-D-glucan biosynthetic process
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways resulting in the formation of (1->3)-beta-D-glucans, compounds composed of glucose residues linked by (1->3)-beta-D-glucosidic bonds, found in the walls of cells.


go_id: GO:0090335
term: regulation of brown fat cell differentiation
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.


go_id: GO:0090336
term: positive regulation of brown fat cell differentiation
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of brown fat cell differentiation. Brown fat cell differentiation is the process in which a relatively unspecialized cell acquires specialized features of a brown adipocyte, an animal connective tissue cell involved in adaptive thermogenesis. Brown adipocytes contain multiple small droplets of triglycerides and a high number of mitochondria.


go_id: GO:0090337
term: regulation of formin-nucleated actin cable assembly
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.


go_id: GO:0090338
term: positive regulation of formin-nucleated actin cable assembly
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.


go_id: GO:0090339
term: negative regulation of formin-nucleated actin cable assembly
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of formin-nucleated actin cable assembly. Formin-nucleated actin cable assembly is the aggregation, arrangement and bonding together of a set of components to form a formin-nucleated actin cable. A formin-nucleated actin cable is an actin filament bundle that consists of short filaments organized into bundles of uniform polarity, and is nucleated by formins.


go_id: GO:0090340
term: positive regulation of secretion of lysosomal enzymes
ontology: BP
definition:
Any process that increases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell.


go_id: GO:0090341
term: negative regulation of secretion of lysosomal enzymes
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of secretion of lysosomal enzymes, the controlled release of lysosomal enzymes by a cell.


go_id: GO:0090345
term: cellular organohalogen metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells.


go_id: GO:0090346
term: cellular organofluorine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells.


go_id: GO:0090347
term: regulation of cellular organohalogen metabolic process
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells.


go_id: GO:0090348
term: regulation of cellular organofluorine metabolic process
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells.


go_id: GO:0090349
term: negative regulation of cellular organohalogen metabolic process
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organohalogen compounds, as carried out by individual cells.


go_id: GO:0090350
term: negative regulation of cellular organofluorine metabolic process
ontology: BP
definition:
Any process that decreases the rate, frequency or extent of the chemical reactions and pathways involving organofluorine compounds, as carried out by individual cells.


go_id: GO:0090351
term: seedling development
ontology: BP
definition:
The process whose specific outcome is the progression of the seedling over time, beginning with seed germination and ending when the first adult leaves emerge.


go_id: GO:0090352
term: regulation of nitrate assimilation
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the uptake, from the environment, of nitrates, inorganic or organic salts and esters of nitric acid and the subsequent reduction of nitrate ion to other, less highly oxidized, inorganic nitrogenous substances.


go_id: GO:0090354
term: regulation of auxin metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth.


go_id: GO:0090355
term: positive regulation of auxin metabolic process
ontology: BP
definition:
Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth.


go_id: GO:0090356
term: negative regulation of auxin metabolic process
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways involving auxins, plant hormones that regulate aspects of plant growth.


go_id: GO:0090357
term: regulation of tryptophan metabolic process
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.


go_id: GO:0090358
term: positive regulation of tryptophan metabolic process
ontology: BP
definition:
Any process that increases the frequency, rate or extent of the chemical reactions and pathways involving tryptophan, the chiral amino acid 2-amino-3-(1H-indol-3-yl)propanoic acid.


go_id: GO:0090359
term: negative regulation of abscisic acid biosynthetic process
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of the chemical reactions and pathways resulting in the formation of abscisic acid.


go_id: GO:0090360
term: platelet-derived growth factor production
ontology: BP
definition:
The appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0090361
term: regulation of platelet-derived growth factor production
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0090362
term: positive regulation of platelet-derived growth factor production
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of the appearance of any platelet-derived growth factor due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0090363
term: regulation of proteasome core complex assembly
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active 20S proteasome core particle complex that does not contain any regulatory particles.


go_id: GO:0090364
term: regulation of proteasome assembly
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the aggregation, arrangement and bonding together of a mature, active proteasome complex.


go_id: GO:0090365
term: regulation of mRNA modification
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically.


go_id: GO:0090366
term: positive regulation of mRNA modification
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically.


go_id: GO:0090367
term: negative regulation of mRNA modification
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of the covalent alteration of one or more nucleotides within an mRNA molecule to produce an mRNA molecule with a sequence that differs from that coded genetically.


go_id: GO:0090368
term: regulation of ornithine metabolic process
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis.


go_id: GO:0090370
term: negative regulation of cholesterol efflux
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of cholesterol efflux. Cholesterol efflux is the directed movement of cholesterol, cholest-5-en-3-beta-ol, out of a cell or organelle.


go_id: GO:0090371
term: regulation of glycerol transport
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0090372
term: positive regulation of glycerol transport
ontology: BP
definition:
Any process that increases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0090373
term: negative regulation of glycerol transport
ontology: BP
definition:
Any process that decreases the rate, frequency, or extent of the directed movement of glycerol into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.


go_id: GO:0090374
term: oligopeptide export from mitochondrion
ontology: BP
definition:
The process in which an oligopeptide is transported out of the mitochondrial matrix. Oligopeptides are molecules that contain a small number (2 to 20) of amino-acid residues connected by peptide linkages.


go_id: GO:0090375
ontology: BP
term:
negative regulation of transcription from RNA polymerase II promoter in response to iron ion starvation

definition:
Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of deprivation of iron ions.


go_id: GO:0090376
term: seed trichome differentiation
ontology: BP
definition:
The process in which a relatively unspecialized epidermal cell acquires the specialized features of a seed trichome. A seed trichome is a trichome that develops from seed coat epidermis and is often long with putative dispersal function.


go_id: GO:0090377
term: seed trichome initiation
ontology: BP
definition:
The process in which the developmental fate of an epidermal cell becomes restricted such that it will develop into a seed trichome, causing a change in the orientation of cell division in the ovule epidermis at or just before anthesis.


go_id: GO:0090378
term: seed trichome elongation
ontology: BP
definition:
The process in which a seed trichome irreversibly increases in size in one [spatial] dimension or along one axis, resulting in the morphogenesis of the cell.


go_id: GO:0090379
term: secondary cell wall biogenesis involved in seed trichome differentiation
ontology: BP
definition:
A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of inextensible cellulose- and pectin-containing cell walls that are formed between the plasma membrane and primary cell wall of seed trichomes after cell expansion is complete.


go_id: GO:0090380
term: seed trichome maturation
ontology: BP
definition:
A developmental process, independent of morphogenetic (shape) change, that is required for a seed trichome to attain its fully functional state.


go_id: GO:0090381
term: regulation of heart induction
ontology: BP
definition:
Any process that modulates the rate, frequency, or extent of heart induction. Heart induction is the close range interaction between mesoderm and endoderm or ectoderm that causes cells to change their fates and specify the development of the heart.


go_id: GO:0090382
term: phagosome maturation
ontology: BP
definition:
A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.


go_id: GO:0090383
term: phagosome acidification
ontology: BP
definition:
Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion.


go_id: GO:0090384
term: phagosome-lysosome docking
ontology: BP
definition:
The initial attachment of a phagosome membrane to a lysosome membrane. Docking requires only that the proteins come close enough to interact and adhere.


go_id: GO:0090386
term: phagosome maturation involved in apoptotic cell clearance
ontology: BP
definition:
A process that is carried out at the cellular level which results in the arrangement of constituent parts of a phagosome within a cell and contributes to apoptotic cell clearance. Phagosome maturation begins with endocytosis and formation of the early phagosome and ends with the formation of the hybrid organelle, the phagolysosome.


go_id: GO:0090387
term: phagolysosome assembly involved in apoptotic cell clearance
ontology: BP
definition:
The process in which a phagosome, a vesicle formed by phagocytosis, fuses with a lysosome as a part of apoptotic cell clearance.


go_id: GO:0090388
term: phagosome-lysosome docking involved in apoptotic cell clearance
ontology: BP
definition:
The initial attachment of a phagosome membrane to a lysosome membrane that occurs as a part of apoptotic cell clearance. Docking requires only that the proteins come close enough to interact and adhere.


go_id: GO:0090389
term: phagosome-lysosome fusion involved in apoptotic cell clearance
ontology: BP
definition:
The creation of a phagolysosome from a phagosome and a lysosome as a part of apoptotic cell clearance.


go_id: GO:0090390
term: phagosome acidification involved in apoptotic cell clearance
ontology: BP
definition:
Any process that reduces the pH of the phagosome, measured by the concentration of the hydrogen ion, and occurs as a part of apoptotic cell clearance.


go_id: GO:0090391
term: granum assembly
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly of a granum. A granum is a distinct stack of lamellae seen within chloroplasts.


go_id: GO:0090392
term: sepal giant cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a sepal giant cell. A sepal giant cell is a pavement cell that is part of the sepal epidermis and stretches one fifth the length of the sepal with a chromosome content of 16C.


go_id: GO:0090393
term: sepal giant cell development
ontology: BP
definition:
The process aimed at the progression of a sepal giant cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell.


go_id: GO:0090394
term: negative regulation of excitatory postsynaptic potential
ontology: BP
definition:
Any process that prevents the establishment or decreases the extent of the excitatory postsynaptic potential (EPSP) which is a temporary increase in postsynaptic potential due to the flow of positively charged ions into the postsynaptic cell. The flow of ions that causes an EPSP is an excitatory postsynaptic current (EPSC) and makes it easier for the neuron to fire an action potential.


go_id: GO:0090398
term: cellular senescence
ontology: BP
definition:
A cell aging process stimulated in response to cellular stress, whereby normal cells lose the ability to divide through irreversible cell cycle arrest.


go_id: GO:0090399
term: replicative senescence
ontology: BP
definition:
A cell aging process associated with the dismantling of a cell as a response to telomere shortening and/or cellular aging.


go_id: GO:0090400
term: stress-induced premature senescence
ontology: BP
definition:
A cellular senescence process associated with the dismantling of a cell as a response to environmental factors such as hydrogen peroxide or X-rays.


go_id: GO:0090402
term: oncogene-induced cell senescence
ontology: BP
definition:
A cellular senescence process associated with the dismantling of a cell as a response to oncogenic stress, such as the activation of the Ras oncogenic family.


go_id: GO:0090403
term: oxidative stress-induced premature senescence
ontology: BP
definition:
A cellular senescence process associated with the dismantling of a cell as a response to oxidative stress, e.g. high levels of reactive oxygen species, such as superoxide anions, hydrogen peroxide, and hydroxyl radicals.


go_id: GO:0090407
term: organophosphate biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the biosynthesis of deoxyribose phosphate, the phosphorylated sugar 2-deoxy-erythro-pentose.


go_id: GO:0090408
term: phloem nitrate loading
ontology: BP
definition:
The process of loading nitrate into the sieve tube or companion cell of the phloem for long distance transport from source to sink.


go_id: GO:0090415
term: 7-hydroxymethyl chlorophyll a reductase activity
ontology: MF
definition:
Catalysis of the reaction: 7-hydroxymethyl chlorophyll a + 2 reduced ferredoxin + 2 H+ chlorophyll a + 2 oxidized ferredoxin + H2O.


go_id: GO:0090419
term: negative regulation of transcription involved in G2/M transition of mitotic cell cycle
ontology: BP
definition:
Any process that inhibits or decreases the frequency, rate or extent of transcription of target genes that are transcribed as part of the G2/M transition of the mitotic cell cycle.


go_id: GO:0090421
term: embryonic meristem initiation
ontology: BP
definition:
Initiation of a region of tissue in a plant embryo that is composed of one or more undifferentiated cells capable of undergoing mitosis and differentiation.


go_id: GO:0090422
term: thiamine pyrophosphate transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of thiamine pyrophosphate a substance from one side of a membrane to the other.


go_id: GO:0090423
term: phytochelatin-metal complex formation
ontology: BP
definition:
A phytochelatin metabolic process in which a metal is incorporated with phytochelatin to form a complex.


go_id: GO:0090424
term: phytochelatin-metal-sulfur complex formation
ontology: BP
definition:
A phytochelatin metabolic process in which a metal and exogenous sulfur are incorporated with phytochelatin to form a complex.


go_id: GO:0090425
term: acinar cell differentiation
ontology: BP
definition:
The epithelial cell differentiation process in which a relatively unspecialized cell acquires specialized features of an acinar cell, a secretory cell that is grouped together with other cells of the same type to form grape-shaped clusters known as acini.


go_id: GO:0090428
term: perianth development
ontology: BP
definition:
The process whose specific outcome is the progression of the perianth over time, from its formation to the mature structure. The perianth is a collective phyllome structure composed of two or more petals, sepals, or tepals.


go_id: GO:0090429
term: detection of endogenous biotic stimulus
ontology: BP
definition:
The series of events in which an endogenous biotic stimulus is received by a cell and converted into a molecular signal.


go_id: GO:0090431
term: alkyl caffeate ester biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of ester derivatives of alkyl caffeate.


go_id: GO:0090435
term: protein localization to nuclear envelope
ontology: BP
definition:
A process in which a protein is transported to, or maintained at, a location within a nuclear envelope.


go_id: GO:0090436
term: leaf pavement cell development
ontology: BP
definition:
The process whose specific outcome is the progression of an leaf pavement cell over time, from its formation to the mature structure. Cell development does not include the steps involved in committing a cell to a leaf pavement cell fate.


go_id: GO:0090437
term: socket cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a socket cell, a shoot epidermal cell that surrounds a trichome and provides its support.


go_id: GO:0090439
term: tetraketide alpha-pyrone synthase activity
ontology: MF
definition:
Catalyzes the reaction: a hydroxyacyl-CoA + 3 malonyl-CoA + 2 H+ = a hydroxylated tetraketide alpha-pyrone + 3 CO2 + 4 coenzyme A .


go_id: GO:0090441
term: trehalose biosynthesis in response to heat stress
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.


go_id: GO:0090442
term: trehalose catabolism in response to heat stress
ontology: BP
definition:
The chemical reactions and pathways resulting in the degradation of trehalose that occur as a result of a heat stimulus, a temperature stimulus above the optimal temperature for that organism.


go_id: GO:0090443
term: FAR/SIN/STRIPAK complex
ontology: CC
definition:
A conserved protein phosphatase type 2A complex which contains a protein phosphatase type 2A, a protein phosphatase regulatory subunit, a striatin, an FHA domain protein and other subunits (at least six proteins). In fission yeast this complex negatively regulate the septation initiation network at the spindle pole body.


go_id: GO:0090444
term: regulation of nematode larval development, heterochronic
ontology: BP
definition:
Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and the rate at which this time point is reached.


go_id: GO:0090445
term: positive regulation of nematode larval development, heterochronic
ontology: BP
definition:
Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and increases the rate at which this time point is reached.


go_id: GO:0090446
term: negative regulation of nematode larval development, heterochronic
ontology: BP
definition:
Any process that modulates the consistent predetermined time point at which a nematode larva progresses from an initial condition to a later condition and decreases the rate at which this time point is reached.


go_id: GO:0090447
term: glycerol-3-phosphate 2-O-acyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: an acyl-CoA + sn-glycerol 3-phosphate = CoA + a 2-acyl-sn-glycerol 3-phosphate.


go_id: GO:0090448
term: glucosinolate:proton symporter activity
ontology: MF
definition:
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: glucosinolate(out) + H+(out) = glucosinolate(in) + H+(in).


go_id: GO:0090449
term: phloem glucosinolate loading
ontology: BP
definition:
The process of loading glucosinolates into the sieve tube or companion cell of the phloem for long distance transport from source to sink.


go_id: GO:0090451
term: cotyledon boundary formation
ontology: BP
definition:
The process in which boundaries between a cotyledon and the surrounding tissue are established and maintained.


go_id: GO:0090459
term: aspartate homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of aspartate within an organism or cell.


go_id: GO:0090460
term: threonine homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of threonine within an organism or cell.


go_id: GO:0090461
term: glutamate homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of glutamate within an organism or cell.


go_id: GO:0090462
term: ornithine homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of ornithine within an organism or cell.


go_id: GO:0090463
term: lysine homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of lysine within an organism or cell.


go_id: GO:0090464
term: histidine homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of histidine within an organism or cell.


go_id: GO:0090465
term: arginine homeostasis
ontology: BP
definition:
Any process involved in the maintenance of an internal steady state of arginine within an organism or cell.


go_id: GO:0090470
term: shoot organ boundary specification
ontology: BP
definition:
The process in which the basal boundary between the stem and both vegetative and reproductive organs are established and maintained.


go_id: GO:0090472
term: dibasic protein processing
ontology: BP
definition:
Any protein processing achieved by the cleavage of a peptide bond after two basic amino acids within a protein.


go_id: GO:0090473
term: lys-arg specific dibasic protein processing
ontology: BP
definition:
Any protein processing achieved by the cleavage of a peptide bond after a lysine-arginine amino acid residue combination within a protein.


go_id: GO:0090474
term: arg-arg specific dibasic protein processing
ontology: BP
definition:
Any protein processing achieved by the cleavage of a peptide bond after two consecutive arginine amino acid residues within a protein.


go_id: GO:0090475
term: lys-lys specific dibasic protein processing
ontology: BP
definition:
Any protein processing achieved by the cleavage of a peptide bond after two consecutive lysine amino acid residues within a protein.


go_id: GO:0090480
term: purine nucleotide-sugar transmembrane transport
ontology: BP
definition:
The process in which a purine nucleotide-sugar is transported across a membrane. Purine nucleotide-sugars are purine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative.


go_id: GO:0090481
term: pyrimidine nucleotide-sugar transmembrane transport
ontology: BP
definition:
The process in which a pyrimidine nucleotide-sugar is transported across a membrane. Pyrimidine nucleotide-sugars are pyrimidine nucleotides in glycosidic linkage with a monosaccharide or monosaccharide derivative.


go_id: GO:0090483
term: phosphatidylglycerol-phosphatidylethanolamine phosphatidyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: phosphatidylglycerol + phosphatidylethanolamine = cardiolipin + ethanolamine.


go_id: GO:0090486
term: small RNA 2'-O-methyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to the oxygen atom of a nucleoside residue in a small RNA molecule. Reaction: S-adenosyl-L-methionine + small RNA <=> S-adenosyl-L-homocysteine + small RNA containing a 3'-terminal 2'-O-methylnucleotide.


go_id: GO:0090487
term: secondary metabolite catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of secondary metabolites, the compounds that are not necessarily required for growth and maintenance of cells, and are often unique to a taxon.


go_id: GO:0090488
term: polo box domain specific binding
ontology: MF
definition:
Binding to a polo box domain of a protein. The polo box domain is involved in binding substrates of polo kinases.


go_id: GO:0090489
term: L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating, decarboxylating)
ontology: MF
definition:
Catalyzes the multi-step reaction: L-Tryptophan + 2 Oxygen + 2 NADPH + 2 H+ = Indole-3-acetaldehyde oxime + 3 H2O + 2 NADP+ + CO2. The individual reactions are: (1a) L-tryptophan + O2 + NADPH + H+ = N-hydroxy-L-tryptophan + NADP+ + H2O,(1b) N-hydroxy-L-tryptophan + O2 + NADPH + H+ = N,N-dihydroxy-L-tryptophan + NADP+ + H2O, and (1c) N,N-dihydroxy-L-tryptophan = (E)-indol-3-ylacetaldoxime + CO2 + H2O.


go_id: GO:0090491
term: N-hydroxy-L-tryptophan,NADPH:oxygen oxidoreductase (N-hydroxylating)
ontology: MF
definition:
Catalyzes the reaction: N-Hydroxy-L-tryptophan + Oxygen + NADPH + H+ = N,N-Dihydroxy-L-tryptophan + NADP+ + H2O.


go_id: GO:0090497
term: mesenchymal cell migration
ontology: BP
definition:
The orderly movement of a mesenchymal cell from one site to another, often during the development of a multicellular organism.


go_id: GO:0090498
term: extrinsic component of Golgi membrane
ontology: CC
definition:
The component of a Golgi membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0090499
term: pimelyl-[acyl-carrier protein] methyl ester esterase activity
ontology: MF
definition:
Catalysis of the reaction: pimelyl-[acyl-carrier protein] methyl ester + H2O = pimelyl-[acyl-carrier protein] + methanol.


go_id: GO:0090500
term: endocardial cushion to mesenchymal transition
ontology: BP
definition:
A transition where an endocardial cushion cell loses apical/basolateral polarity, severs intercellular adhesive junctions, degrades basement membrane components and becomes a migratory mesenchymal cell.


go_id: GO:0090501
term: RNA phosphodiester bond hydrolysis
ontology: BP
definition:
The RNA metabolic process in which the phosphodiester bonds between ribonucleotides are cleaved by hydrolysis.


go_id: GO:0090502
term: RNA phosphodiester bond hydrolysis, endonucleolytic
ontology: BP
definition:
The chemical reactions and pathways involving the hydrolysis of internal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides.


go_id: GO:0090503
term: RNA phosphodiester bond hydrolysis, exonucleolytic
ontology: BP
definition:
The chemical reactions and pathways involving the hydrolysis of terminal 3',5'-phosphodiester bonds in one or two strands of ribonucleotides.


go_id: GO:0090506
term: axillary shoot meristem initiation
ontology: BP
definition:
A developmental process that results in the initiation of an axillary shoot meristem. An axillary shoot meristem is a shoot meristem formed in the axil of a leaf.


go_id: GO:0090507
term: phenylethylamine metabolic process involved in synaptic transmission
ontology: BP
definition:
The chemical reactions and pathways involving phenylethylamine that contribute to synaptic transmission.


go_id: GO:0090508
term: phenylethylamine biosynthetic process involved in synaptic transmission
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of phenylethylamine that contribute to synaptic transmission.


go_id: GO:0090510
term: anticlinal cell division
ontology: BP
definition:
A cell division process where the division plane is perpendicular to the surface of the organ. It adds cells to the existing cell layer or cell file.


go_id: GO:0090511
term: periclinal cell division
ontology: BP
definition:
A cell division process where the division plane is parallel to the surface of the organ. It creates a new cell layer or cell file.


go_id: GO:0090512
term: eisosome membrane domain/MCC
ontology: CC
definition:
A plasma membrane part that is composed of a furrow-like plasma membrane domain and associated integral transmembrane proteins.


go_id: GO:0090519
term: anoxia protection
ontology: BP
definition:
Any process in which an organism or cell protects itself from anoxia, which may also result in resistance to repeated exposure to anoxia.


go_id: GO:0090521
term: podocyte cell migration
ontology: BP
definition:
The orderly movement of a podocyte from one site to another, often during the development of a multicellular organism or multicellular structure. A podocyte is a specialized kidney epithelial cell.


go_id: GO:0090522
term: vesicle tethering involved in exocytosis
ontology: BP
definition:
The initial, indirect interaction between a secretory vesicle membrane and a site of exocytosis in the plasma membrane. This interaction is mediated by tethering factors (or complexes), which interact with both membranes. Interaction can occur via direct binding  to membrane phospholipids or membrane proteins, or via binding to vesicle coat proteins. This process is distinct from and prior to docking and fusion.


go_id: GO:0090527
term: actin filament reorganization
ontology: BP
definition:
A process that is carried out at the cellular level which results in dynamic structural changes to the arrangement of actin filaments.


go_id: GO:0090528
term: smooth septate junction assembly
ontology: BP
definition:
The assembly of a smooth septate junction, a septate junction that lacks the regular arrays of electron-dense septae found in pleated septate junctions.


go_id: GO:0090529
term: cell septum assembly
ontology: BP
definition:
The assembly and arrangement of a cellular component that is composed of peptidoglycan and often chitin in addition to other materials and usually forms perpendicular to the long axis of a cell or hypha. It grows centripetally from the cell wall to the center of the cell and often functions in the compartmentalization of a cell into two daughter cells.


go_id: GO:0090531
term: L-ascorbic acid biosynthetic process via GDP-alpha-D-mannose
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate GDP-alpha-D-mannose.


go_id: GO:0090532
term: L-ascorbic acid biosynthetic process via UDP-alpha-D-glucuronate
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of L-ascorbic acid via the intermediate UDP-alpha-D-glucuronate.


go_id: GO:0090533
term: cation-transporting ATPase complex
ontology: CC
definition:
Protein complex that carries out the reaction: ATP + H2O + cation(out) = ADP + phosphate + cation(in).


go_id: GO:0090535
term: WICH complex
ontology: CC
definition:
An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and WSTF (Williams Syndrome Transcription Factor). WICH plays roles in regulation of RNAP I and III transcription and in DNA replication and repair.


go_id: GO:0090536
term: NoRC complex
ontology: CC
definition:
An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2H in mammals, which contain two ISWI homologs) and a Tip5 homolog. In mammals, NoRC is involved in regulation of transcription from RNAP I and RNA polymerase III promoters.


go_id: GO:0090537
term: CERF complex
ontology: CC
definition:
An ISWI complex that contains an ATPase subunit of the ISWI family (specifically SNF2L in mammals, which contain two ISWI homologs) and a CECR2 homolog. In mammals, CERF is involved in regulation of transcription from RNA polymerase II promoters.


go_id: GO:0090540
term: bacterial cellulose biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of cellulose, a linear beta1-4 glucan of molecular mass 50-400 kDa with the pyranose units in the -4C1 conformation, as it occurs in certain types of bacteria, mainly Acetobacter, Sarcina ventriculi and Agrobacteria.


go_id: GO:0090541
term: MIT domain binding
ontology: MF
definition:
Binding to a MIT protein domain. The MIT domain is found in vacuolar sorting proteins, spastin (probable ATPase involved in the assembly or function of nuclear protein complexes), and a sorting nexin, which may play a role in intracellular trafficking.


go_id: GO:0090542
term: ELYC domain binding
ontology: MF
definition:
Binding to a ELYC protein domain. The ELYC domain is an approximately 150 amino acid sequence which contains a highly conserved tetrapeptide sequence, ELYC.


go_id: GO:0090543
term: Flemming body
ontology: CC
definition:
A cell part that is the central region of the midbody characterized by a gap in alpha-tubulin staining. It is a dense structure of antiparallel microtubules from the central spindle in the middle of the intercellular bridge.


go_id: GO:0090545
term: CHD-type complex
ontology: CC
definition:
A SWI/SNF-type complex that contains a subunit from the CHD(Chromodomain helicase DNA-binding) family. The CHD family is characterized by two signature sequence motifs: tandem chromodomains located in the N-terminal region, and the SNF2-like ATPase domain located in the central region of the protein structure.


go_id: GO:0090546
term: chlorophyll fluorescence
ontology: BP
definition:
The process by which excess light energy absorbed by chlorophyll and not used to drive photosynthesis is re-emitted as light.


go_id: GO:0090547
term: response to low humidity
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of low humidity stimulus, reduced moisture in the atmosphere.


go_id: GO:0090548
term: response to nitrate starvation
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of nitrate.


go_id: GO:0090549
term: response to carbon starvation
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of a carbon source.


go_id: GO:0090550
term: response to molybdenum starvation
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of molybdenum.


go_id: GO:0090551
term: response to manganese starvation
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a starvation stimulus, deprivation of manganese.


go_id: GO:0090554
term: phosphatidylcholine floppase activity
ontology: MF
definition:
Catalysis of the movement of phosphatidylcholine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.


go_id: GO:0090555
term: phosphatidylethanolamine flippase activity
ontology: MF
definition:
Catalysis of the movement of phosphatidylethanolamine from the exoplasmic to the cytosolic leaftlet of a membrane, using energy from the hydrolysis of ATP.


go_id: GO:0090556
term: phosphatidylserine floppase activity
ontology: MF
definition:
Catalysis of the movement of phosphatidylserine from the cytosolic to the exoplasmic leaftlet of a membrane, using energy from the hydrolysis of ATP.


go_id: GO:0090557
term: establishment of endothelial intestinal barrier
ontology: BP
definition:
The establishment of a barrier between endothelial cell layers of the intestine to exert specific and selective control over the passage of water and solutes, thus allowing formation and maintenance of compartments that differ in fluid and solute composition.


go_id: GO:0090558
term: plant epidermis development
ontology: BP
definition:
The process whose specific outcome is the progression of the plant epidermis over time, from its formation to the mature structure.


go_id: GO:0090559
term: regulation of membrane permeability
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by a membrane.


go_id: GO:0090560
term: 2-(3-amino-3-carboxypropyl)histidine synthase activity
ontology: MF
definition:
Catalysis of the reaction S-adenosyl-L-methionine + L-histidine-[translation elongation factor 2] = S-methyl-5-thioadenosine + 2-[(3S)-3-amino-3-carboxypropyl]-L-histidine-[translation elongation factor 2].


go_id: GO:0090561
term: nuclear migration during mitotic telophase
ontology: BP
definition:
The dynein-driven microtubule based nuclear migration, whereby daughter nuclei are positioned away from the cell division site prior to cytokinesis.


go_id: GO:0090562
ontology: MF
term:
protein-N(PI)-phosphohistidine-N,N'-diacetylchitobiose phosphotransferase system transporter activity

definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N,N'-diacetylchitobiose(out) = protein histidine + N,N'-diacetylchitobiose phosphate(in).


go_id: GO:0090563
term: protein-phosphocysteine-sugar phosphotransferase activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + sugar(out) = protein cysteine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0090564
term: protein-phosphocysteine-glucose phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucose(out) = protein cysteine + glucose phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0090565
term: protein-phosphocysteine-mannitol phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannitol(out) = protein cysteine + mannitol phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.


go_id: GO:0090566
term: protein-phosphocysteine-N,N'-diacetylchitobiose phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N,N'-diacetylchitobiose(out) = protein cysteine + N,N'-diacetylchitobiose phosphate(in).


go_id: GO:0090567
term: reproductive shoot system development
ontology: BP
definition:
The process whose specific outcome is the progression of a reproductive shoot system over time, from its formation to the mature structure.


go_id: GO:0090570
term: RNA polymerase I transcription repressor complex
ontology: CC
definition:
A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase I promoter.


go_id: GO:0090571
term: RNA polymerase II transcription repressor complex
ontology: CC
definition:
A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase II promoter.


go_id: GO:0090572
term: RNA polymerase III transcription repressor complex
ontology: CC
definition:
A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase III promoter.


go_id: GO:0090573
term: RNA polymerase IV transcription repressor complex
ontology: CC
definition:
A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase IV promoter.


go_id: GO:0090574
term: RNA polymerase V transcription repressor complex
ontology: CC
definition:
A protein complex, located in the nucleus, that possesses activity that prevents or downregulates transcription from a RNA polymerase V promoter.


go_id: GO:0090575
term: RNA polymerase II transcription regulator complex
ontology: CC
definition:
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase II.


go_id: GO:0090576
term: RNA polymerase III transcription regulator complex
ontology: CC
definition:
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase III.


go_id: GO:0090577
term: RNA polymerase IV transcription regulator complex
ontology: CC
definition:
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase IV.


go_id: GO:0090578
term: RNA polymerase V transcription regulator complex
ontology: CC
definition:
A transcription factor complex that acts at a regulatory region of a gene transcribed by RNA polymerase V.


go_id: GO:0090580
term: phosphodiesterase activity, acting on 3'-phosphoglycolate-terminated DNA strands
ontology: MF
definition:
Catalysis of the hydrolytic removal of phosphoglycolate from the 3'-terminus of a 3'-phosphoglycolate-terminated DNA strand.


go_id: GO:0090581
term: protein-phosphocysteine-mannosylglycerate-phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + mannosylglycerate(out) = protein cysteine + mannosylglycerate phosphate(in).


go_id: GO:0090582
term: protein-phosphocysteine-D-fructose-phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-fructose(out) = protein cysteine + D-fructose-1-phosphate(in).


go_id: GO:0090583
term: protein-phosphocysteine-D-sorbitol-phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + D-sorbitol(out) = protein cysteine + D-sorbitol-1-phosphate(in).


go_id: GO:0090584
term: protein-phosphocysteine-galactitol-phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + galactitol(out) = protein cysteine + galactitol-6-phosphate(in).


go_id: GO:0090585
term: protein-phosphocysteine-L-ascorbate-phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + L-ascorbate(out) = protein cysteine + L-ascorbate-6-phosphate(in).


go_id: GO:0090586
term: protein-phosphocysteine-N-acetylglucosamine phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylglucosamine (out) = protein cysteine + N-acetylglucosamine-6-phosphate (in).


go_id: GO:0090587
term: protein-phosphocysteine-glucosamine phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + glucosamine (out) = protein cysteine + glucosamine-6-phosphate (in).


go_id: GO:0090588
term: protein-phosphocysteine-N-acetylmuramate phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + N-acetylmuramate (out) = protein cysteine + N-acetylmuramate-6-phosphate (in).


go_id: GO:0090589
term: protein-phosphocysteine-trehalose phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein S-phosphocysteine + trehalose (out) = protein cysteine + trehalose-6-phosphate (in).


go_id: GO:0090590
term: protein-N(PI)-phosphohistidine-D-glucosamine phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + D-glucosamine(out) = protein histidine + glucosamine-6-phosphate(in).


go_id: GO:0090591
term: protein-N(PI)-phosphohistidine-N-acetyl-mannosamine phosphotransferase system transporter activity
ontology: MF
definition:
Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + N-acetyl-mannosamine(out) = protein histidine +N-acetyl- mannosamine-6-phosphate(in).


go_id: GO:0090593
term: peptidyl-histidine autophosphorylation
ontology: BP
definition:
The phosphorylation by a protein of one or more of its own histidine residues, or a histidine residue on an identical protein.


go_id: GO:0090594
term: inflammatory response to wounding
ontology: BP
definition:
The immediate defensive reaction by vertebrate tissue to injury caused by chemical or physical agents.


go_id: GO:0090596
term: sensory organ morphogenesis
ontology: BP
definition:
Morphogenesis of a sensory organ. A sensory organ is defined as a tissue or set of tissues that work together to receive and transmit signals from external or internal stimuli. Morphogenesis is the process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.


go_id: GO:0090597
term: nematode male tail mating organ morphogenesis
ontology: BP
definition:
The process in which the anatomical structures of the nematode male tail mating organ are generated and organized. The male tail is a sensory organ required for mating and, in C. elegans, consists of ray sensilla, an acellular cuticular fan, a sensory hook, and protracting, copulatory spicules.


go_id: GO:0090598
term: male anatomical structure morphogenesis
ontology: BP
definition:
The processes by which anatomical structures that are only present in the male organism are generated and organized.


go_id: GO:0090599
term: alpha-glucosidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of terminal, non-reducing alpha-linked alpha-D-glucose residue with release of alpha-D-glucose.


go_id: GO:0090600
term: alpha-1,3-glucosidase activity
ontology: MF
definition:
Catalysis of the hydrolysis of terminal, non-reducing alpha-(1->3)-linked alpha-D-glucose residues with release of alpha-D-glucose.


go_id: GO:0090602
term: sieve element enucleation
ontology: BP
definition:
The process in which nucleated precursor cells lose their nucleus as part of sieve element differentiation. The nuclear contents are released and degraded in the cytoplasm at the same time as other organelles are rearranged and the cytosol is degraded.


go_id: GO:0090603
term: sieve element differentiation
ontology: BP
definition:
The process whereby a relatively unspecialized cell acquires specialized features of a sieve element.


go_id: GO:0090604
term: surface biofilm formation
ontology: BP
definition:
A process in which planktonically growing microorganisms grow at the surface of a liquid-air interface and produce extracellular polymers that facilitate matrix formation, resulting in a change in the organisms' growth rate and gene transcription.


go_id: GO:0090605
term: submerged biofilm formation
ontology: BP
definition:
A process in which planktonically growing microorganisms aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription.


go_id: GO:0090606
term: single-species surface biofilm formation
ontology: BP
definition:
A process in which microorganisms produce an extracellular matrix and form multicellular aggregates at an air-liquid interface.


go_id: GO:0090609
term: single-species submerged biofilm formation
ontology: BP
definition:
A process in which planktonically growing microorganisms of the same species aggregate and grow on solid substrates under the flow of a liquid and produce extracellular polymers that facilitate attachment and matrix formation, resulting in a change in the organisms' growth rate and gene transcription.


go_id: GO:0090610
term: bundle sheath cell fate specification
ontology: BP
definition:
The process in which a cell becomes capable of differentiating autonomously into a bundle sheath cell in an environment that is neutral with respect to the developmental pathway; upon specification, the cell fate can be reversed.


go_id: GO:0090611
term: ubiquitin-independent protein catabolic process via the multivesicular body sorting pathway
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a protein or peptide, via the multivesicular body (MVB) sorting pathway; proteins are sorted into MVBs, and delivered to a lysosome/vacuole for degradation.  This process is independent of ubiquitination.


go_id: GO:0090612
term: cAMP deaminase activity
ontology: MF
definition:
Catalysis of the reaction: cyclic adenosine monophosphate + H2O = cyclic inosine monophosphate + NH3.


go_id: GO:0090615
term: mitochondrial mRNA processing
ontology: BP
definition:
Steps involved in processing precursor RNAs arising from transcription of operons in the mitochondrial genome into mature mRNAs.


go_id: GO:0090616
term: mitochondrial mRNA 3'-end processing
ontology: BP
definition:
Any process involved in forming the mature 3' end of an mRNA molecule that derives from the mitochondrial genome.


go_id: GO:0090617
term: mitochondrial mRNA 5'-end processing
ontology: BP
definition:
Any process involved in forming the mature 5' end of an mRNA molecule that derives from the mitochondrial genome.


go_id: GO:0090618
term: DNA clamp unloading
ontology: BP
definition:
The process of removing the PCNA complex from DNA when Okazaki fragments are completed or the replication fork terminates.


go_id: GO:0090619
term: meiotic spindle pole
ontology: CC
definition:
Either of the ends of a meiotic spindle, a spindle that forms as part of meiosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.


go_id: GO:0090624
term: endoribonuclease activity, cleaving miRNA-paired mRNA
ontology: MF
definition:
Catalysis of the endonucleolytic cleavage of the mRNA in a double-stranded RNA molecule formed by the base pairing of an mRNA with an miRNA.


go_id: GO:0090625
term: siRNA-mediated gene silencing by mRNA destabilization
ontology: BP
definition:
An siRNA-mediated post-transcriptional gene silencing pathway in which small interfering RNAs (siRNAs) direct the cleavage of target mRNAs. Once incorporated into a RNA-induced silencing complex (RISC), an siRNA will typically direct cleavage by base pairing with perfect or near-perfect complementarity to the target mRNA.


go_id: GO:0090627
term: plant epidermal cell differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a plant epidermal cell.


go_id: GO:0090628
term: plant epidermal cell fate specification
ontology: BP
definition:
The process in which a cell becomes capable of differentiating autonomously into a plant epidermal cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed.


go_id: GO:0090629
term: lagging strand initiation
ontology: BP
definition:
The process in which the synthesis of DNA from a template strand in a net 3' to 5' direction is started.


go_id: GO:0090630
term: activation of GTPase activity
ontology: BP
definition:
Any process that initiates the activity of an inactive GTPase through the replacement of GDP by GTP.


go_id: GO:0090635
term: extracellular core region of desmosome
ontology: CC
definition:
The desmosomal part containing the desmosomal cadherins, desmogleins and desmocollins, that establish contact and adhere to neighboring cells in a Ca2+-dependent manner.


go_id: GO:0090636
term: outer dense plaque of desmosome
ontology: CC
definition:
The desmosomal part containing plakoglobins, plakophilins, the N-termini of desmoplakins,  as well as the cytoplasmic tails of the desmosomal cadherins, which together attach the plaque to the plasma membrane.


go_id: GO:0090637
term: inner dense plaque of desmosome
ontology: CC
definition:
The desmosomal part containing the C-termini of desmoplakins which interact with the keratin intermediate filaments, serving to tether the intermediate filaments to the plasma membrane.


go_id: GO:0090638
term: phosphatidylcholine biosynthesis from phosphatidylethanolamine
ontology: BP
definition:
The phosphatidylcholine biosynthetic process that depends on direct conversion of the phosphatidyl-base phosphatidylethanolamine to phosphatidylcholine by successive methylations.


go_id: GO:0090639
term: phosphatidylcholine biosynthesis from choline and CDP-diacylglycerol
ontology: BP
definition:
The phosphatidylcholine biosynthetic process that involves a one-step direct condensation of choline with CDP-diacylglycerol to form phosphatidylcholine.


go_id: GO:0090640
term: phosphatidylcholine biosynthesis from sn-glycero-3-phosphocholine
ontology: BP
definition:
The phosphatidylcholine biosynthetic process that involves the two-step acylation of sn-glycero-3-phosphocholine to a phosphatidylcholine.


go_id: GO:0090641
term: microsporidian-type endospore
ontology: CC
definition:
The middle layer in a microsporidian spore wall that lies under the exospore and outside the plasma membrane, containing chitin and proteins.


go_id: GO:0090642
term: microsporidian-type exospore
ontology: CC
definition:
The dense, protein rich outermost layer of a microsporidian spore wall that lies above the endospore.


go_id: GO:0090643
term: inflorescence phyllotactic patterning
ontology: BP
definition:
The radial pattern formation process that results in the formation of flowers around a central axis in an inflorescence meristem.


go_id: GO:0090644
term: age-related resistance
ontology: BP
definition:
An innate immune response that is positively correlated with host plant development. As a plant develops, its innate resistance to pathogenic infections increases. The mechanisms involved in age-related resistance differ in nature or in aspects of regulation from the hypersensitive response (HR), systemic acquired resistance (SAR), or induced systemic resistance (ISR).


go_id: GO:0090646
term: mitochondrial tRNA processing
ontology: BP
definition:
The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group,  in the mitochondrion.


go_id: GO:0090648
term: response to environmental enrichment
ontology: BP
definition:
Any process that results in a change in state or activity of an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the provision of a combination of complex inanimate and social stimulations in the organism's housing environment.


go_id: GO:0090649
term: response to oxygen-glucose deprivation
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose.


go_id: GO:0090650
term: cellular response to oxygen-glucose deprivation
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of the deprivation of oxygen and glucose.


go_id: GO:0090651
term: apical cytoplasm
ontology: CC
definition:
The region of the cytoplasm located at the apical side of the cell. Used in reference to animal polarized epithelial cells.


go_id: GO:0090652
term: basolateral cytoplasm
ontology: CC
definition:
The region of the cytoplasm located at the basolateral side of the cell. Used in reference to animal polarized epithelial cells.


go_id: GO:0090653
term: apical recycling endosome
ontology: CC
definition:
Tubulo-vesicular structure located in the apical cytoplasm that participates in apical cargo recycling in polarized epithelial cells.


go_id: GO:0090654
term: basolateral recycling endosome
ontology: CC
definition:
Tubulo-vesicular structure located in the basolateral cytoplasm that participates in basolateral cargo recycling in polarized epithelial cells.


go_id: GO:0090655
term: double-stranded/single-stranded junction telomeric DNA binding
ontology: MF
definition:
Binding to a junction formed at the point where double-stranded telomeric DNA becomes a single-stranded G-rich telomeric DNA 3' overhang.


go_id: GO:0090656
term: t-circle formation
ontology: BP
definition:
A telomere maintenance process that results in the formation of a telomeric circle, or t-circle. A t-circle is an extrachromosomal duplex or single-stranded circular DNA molecule composed of t-arrays. T-circles are involved in the control of telomere length via alternative-lengthening of telomeres (ALT) pathway and telomere rapid deletion (TRD).


go_id: GO:0090657
term: telomeric loop disassembly
ontology: BP
definition:
The telomere maintenance process in which telomeric loops are disassembled to permit efficient telomere replication.


go_id: GO:0090658
term: cone matrix sheath
ontology: CC
definition:
A biochemically and structurally distinct domain of the retinal interphotoreceptor matrix that is specifically associated with cone photoreceptor cell inner and outer segments.


go_id: GO:0090659
term: walking behavior
ontology: BP
definition:
The behavior of an organism relating to the progression of that organism along the ground by the process of lifting and setting down each leg.


go_id: GO:0090660
term: cerebrospinal fluid circulation
ontology: BP
definition:
The neurological system process driven by motile cilia on ependymal cells of the brain by which cerebrospinal fluid circulates from the sites of secretion to the sites of absorption. In ventricular cavities, the flow is unidirectional and rostrocaudal, in subarachnoid spaces, the flow is multi-directional.


go_id: GO:0090661
term: box H/ACA telomerase RNP complex
ontology: CC
definition:
A box H/ACA ribonucleoprotein complex that contains the RNA component of vertebrate telomerase, the enzyme essential for the replication of chromosome termini in most eukaryotes. This ribonucleoprotein complex is a structural box H/ACA RNP, which does not have the catalytic pseudouridylation function shared by the majority of H/ACA RNPs present in the cell.


go_id: GO:0090663
term: galanin-activated signaling pathway
ontology: BP
definition:
The series of molecular signals generated as a consequence of the peptide neurotransmitter galanin binding to a cell surface receptor.


go_id: GO:0090664
term: response to high population density
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or a multicellular organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a higher than normal number of multicellular organisms living per unit area.


go_id: GO:0090665
term: glycoprotein complex
ontology: CC
definition:
A protein complex containing at least one glycosylated protein, may be held together by both covalent and noncovalent bonds.


go_id: GO:0090666
term: scaRNA localization to Cajal body
ontology: BP
definition:
A process in which a small Cajal body-specific RNA is transported to, or maintained in, a Cajal body.


go_id: GO:0090667
term: cell chemotaxis to vascular endothelial growth factor
ontology: BP
definition:
The directed movement of a motile cell in response to the presence of vascular endothelial growth factor (VEGF).


go_id: GO:0090668
term: endothelial cell chemotaxis to vascular endothelial growth factor
ontology: BP
definition:
The directed movement of an endothelial cell in response to the presence of vascular endothelial growth factor (VEGF).


go_id: GO:0090675
term: intermicrovillar adhesion
ontology: BP
definition:
The cell-cell adhesion process by which adjacent microvilli attach to each other through Ca(2+)-dependent adhesion links made of protocadherin-24 and mucin-like protocadherin.


go_id: GO:0090676
term: calcium ion transmembrane transport via low voltage-gated calcium channel
ontology: BP
definition:
A process in which a calcium ion is transported from one side of a membrane to the other by means of a low voltage-gated calcium channel.


go_id: GO:0090677
term: reversible differentiation
ontology: BP
definition:
A phenotypic switching process where a cell reversibly differentiates and dedifferentiates from one cell type into another.


go_id: GO:0090678
term: cell dedifferentiation involved in phenotypic switching
ontology: BP
definition:
A cell dedifferentiation process that is a part of a reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations.


go_id: GO:0090679
term: cell differentiation involved in phenotypic switching
ontology: BP
definition:
A cell differentiation process that is a part of a reversible switch of a cell from one cell type or form to another, at a frequency above the expected frequency for somatic mutations.


go_id: GO:0090684
term: contact chemoreceptor activity
ontology: MF
definition:
A non-GPCR transmembrane signaling receptor activity that is responsible for contact chemoreception.


go_id: GO:0090685
term: RNA localization to nucleus
ontology: BP
definition:
A macromolecular localization process in which RNA is transported to and maintained in a location within the nucleus.


go_id: GO:0090686
term: glycine betaine-activated nonselective monovalent cation channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a monovalent cation by a channel that opens when glycine betaine has been bound by the channel complex or one of its constituent parts.


go_id: GO:0090689
term: cleavage furrow leading edge
ontology: CC
definition:
The 'trough' of the cleavage furrow. This is the part of the cleavage furrow closest to the contractile ring.


go_id: GO:0090691
term: formation of plant organ boundary
ontology: BP
definition:
The regionalization process that specifies plant organ primordium boundaries resulting in a restriction of organogenesis to a limited spatial domain and keeping the organ separate from surrounding tissues.


go_id: GO:0090692
term: mitochondrial membrane scission site
ontology: CC
definition:
The site on the mitochondrial membrane where the separation of a single continuous mitochondrial membrane into two membranes occurs as a final step in mitochondrial fission.


go_id: GO:0090693
term: plant organ senescence
ontology: BP
definition:
A plant organ developmental process during which a plant dismantles cellular components to reclaim the cellular building blocks and nutrients that have been deposited in the plant organs during growth.


go_id: GO:0090694
term: Scc2-Scc4 cohesin loading complex
ontology: CC
definition:
A eukaryotically conserved heterodimeric protein complex (comprising adherin and the chromatid cohesion factor MAU2/Scc4/Ssl3) required for the loading of a cohesin, complex onto DNA.


go_id: GO:0090695
term: Wpl/Pds5 cohesin loading/unloading complex
ontology: CC
definition:
A eukaryotically conserved heterodimeric protein complex (comprising Wings apart-like protein and the Pds5 Armadillo repeat cohesin associated protein) involved in the loading and unloading of a cohesin complex onto DNA.


go_id: GO:0090696
term: post-embryonic plant organ development
ontology: BP
definition:
Development, taking place during the post-embryonic phase of a plant tissue or tissues that work together to perform a specific function or functions. Development pertains to the process whose specific outcome is the progression of a structure over time, from its formation to the mature structure. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.


go_id: GO:0090697
term: post-embryonic plant organ morphogenesis
ontology: BP
definition:
Morphogenesis, during the post-embryonic phase, of a plant tissue or tissues that work together to perform a specific function or functions. Morphogenesis pertains to process in which anatomical structures are generated and organized. Organs are commonly observed as visibly distinct structures, but may also exist as loosely associated clusters of cells that work together to perform a specific function or functions.


go_id: GO:0090698
term: post-embryonic plant morphogenesis
ontology: BP
definition:
The process, occurring after plant embryonic development, by which anatomical structures are generated and organized.


go_id: GO:0090700
term: maintenance of plant organ identity
ontology: BP
definition:
The process in which the identity of a plant organ is maintained. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


go_id: GO:0090701
term: specification of plant organ identity
ontology: BP
definition:
The regionalization process in which the identity of a plant organ primordium is specified. Identity is considered to be the aggregate of characteristics by which a structure is recognized.


go_id: GO:0090706
term: specification of plant organ position
ontology: BP
definition:
The regionalization process in which information that determines the correct position at which plant organ primordia are formed is generated and perceived resulting in correct positioning of the new plant organ.


go_id: GO:0090709
term: regulation of timing of plant organ formation
ontology: BP
definition:
Any process that modulates the rate, frequency or extent of plant organ formation at a consistent predetermined time point during development.


go_id: GO:0090710
term: phosphomevalonate decarboxylase activity
ontology: MF
definition:
Catalysis of the reaction: ATP + (R)-mevalonate 5-phosphate = ADP + isopentenyl phosphate + CO2 + phosphate.


go_id: GO:0090713
term: immunological memory process
ontology: BP
definition:
Any process of the immune system that can contribute to the formation of immunological memory or an immune response based upon activation of immunological memory.


go_id: GO:0090714
term: innate immunity memory response
ontology: BP
definition:
An immune response mediated by the innate immune system and directed against a previously encountered immunologic stimulus, being quicker and quantitatively better compared with the initial response to that stimulus.


go_id: GO:0090716
term: adaptive immune memory response
ontology: BP
definition:
An immune response directed against a previously encountered antigen, being quicker and quantitatively better compared with the primary response.


go_id: GO:0090717
term: adaptive immune memory response involving T cells and B cells
ontology: BP
definition:
An immune response mediated by reactivated memory T cells and B cells and directed against a previously encountered antigen, being quicker and quantitatively better compared with the primary response.


go_id: GO:0090718
term: adaptive immune effector response
ontology: BP
definition:
An adaptive immune response that involves one or more immune effector processes and takes place during the effector phase of the adaptive immune response.


go_id: GO:0090719
term: adaptive immune effector response involving T cells and B lineage cells
ontology: BP
definition:
An adaptive immune effector response involving T cells and B lineage cells. In the case of B lineage cells, the effector cells are the antibody secreting plasma cells whereas for T cells the effector cells may be helper T cells or cytotoxic T cells.


go_id: GO:0090721
term: primary adaptive immune response involving T cells and B cells
ontology: BP
definition:
An adaptive immune response mediated by naive T or B cells against an antigen not previously encountered by immune system.


go_id: GO:0090722
term: receptor-receptor interaction
ontology: MF
definition:
The aggregation, arrangement and bonding together of two or more different receptor complexes that individually undergo combination with a hormone, neurotransmitter, drug or intracellular messenger to form a higher level receptor complex. The formation of the higher level complex initiates a change in cell function.


go_id: GO:0090725
term: peripheral region of growth cone
ontology: CC
definition:
The non-central region or periphery of the migrating motile tip of a growing nerve cell axon or dendrite.


go_id: GO:0090726
term: cortical dynamic polarity patch
ontology: CC
definition:
A region of the cell cortex that contains a higher concentration of growth polarity factors than the surrounding cortex and that changes position over time. An example is found in fission yeast cells during early mating, in which the GTPase Cdc42 dynamically to discrete zones within the cortex prior to shmoo formation.


go_id: GO:0090727
term: positive regulation of brood size
ontology: BP
definition:
Any process that increases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time.


go_id: GO:0090728
term: negative regulation of brood size
ontology: BP
definition:
Any process that decreases brood size. Brood size is the number of progeny that survive embryogenesis and are cared for at one time.


go_id: GO:0090729
term: toxin activity
ontology: MF
definition:
Interacting selectively with one or more biological molecules in another (target) organism, initiating pathogenesis (leading to an abnormal, generally detrimental state) in the target organism. The activity should refer to an evolved function of the active gene product, i.e. one that was selected for. Examples include the activity of botulinum toxin, and snake venom.


go_id: GO:0090730
term: Las1 complex
ontology: CC
definition:
A four subunit complex, that comprises all the necessary RNA processing enzymes (endonuclease, polynucleotide kinase, and exonuclease) to mediate 'cistronic rRNA transcript ITS2 (internal transcribed spacer) cleavage' (GO:0000448).


go_id: GO:0090731
term: cellular response to very-low-density lipoprotein particle stimulus
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a very-low-density lipoprotein particle stimulus.


go_id: GO:0090732
term: cofilin-actin rod
ontology: CC
definition:
A cellular structure consisting of parallel, hexagonally arranged actin tubules, comprising filamentous actin and disulfide cross-linked cofilin multimers.


go_id: GO:0090733
term: tenascin complex
ontology: CC
definition:
A extracellular matrix complex involved in cell adhesion and cell migration. Typically homotrimeric or homohexameric. In mammals, four complexes exist: Tenascin-C, Tenascin-N (also known as Tenascin-W), Tenascin-X and Tenascin-R.


go_id: GO:0090734
term: site of DNA damage
ontology: CC
definition:
A region of a chromosome at which DNA damage has occurred. DNA damage signaling and repair proteins accumulate at the lesion to respond to the damage and repair the DNA to form a continuous DNA helix.


go_id: GO:0090735
term: DNA repair complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a DNA repair complex.


go_id: GO:0090737
term: telomere maintenance via telomere trimming
ontology: BP
definition:
A process that contributes to the maintenance of proper telomeric length and structure via the activation of telomere shortening pathways that compensate telomerase-dependent excessive telomere elongation. Telomere attrition is mediated by a mechanism which involves the generation of single-stranded C-rich telomeric DNA, and the formation and removal of double-stranded telomeric circular DNA (T-circles). Telomere trimming is an independent pathway to recombination-mediated telomere elongation and the well-documented gradual telomere attrition that accompanies cellular replication.


go_id: GO:0090740
term: integral component of pigment granule membrane
ontology: CC
definition:
The component of the pigment granule membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0093001
term: glycolysis from storage polysaccharide through glucose-1-phosphate
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of a storage polysaccharide into pyruvate through a glucose-1-phosphate intermediate, with the concomitant production of a small amount of ATP and the reduction of NAD to NADH.


go_id: GO:0093002
term: response to nematicide
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nematicide stimulus. Nematicides are chemicals used to kill nematodes.


go_id: GO:0095500
term: acetylcholine receptor signaling pathway
ontology: BP
definition:
The series of molecular signals generated as a consequence of an acetylcholine receptor binding to one of its physiological ligands.


go_id: GO:0097001
term: ceramide binding
ontology: MF
definition:
Binding to a ceramide, a class of lipids composed of sphingosine linked to a fatty acid. Ceramides are a major component of cell membranes.


go_id: GO:0097002
term: mitochondrial inner boundary membrane
ontology: CC
definition:
The portion of the mitochondrial inner membrane that is not invaginated to form cristae. The inner boundary membrane lies parallel to the outer membrane.


go_id: GO:0097003
term: adipokinetic hormone receptor activity
ontology: MF
definition:
Combining with an adipokinetic hormone to initiate a change in cell activity. Adipokinetic hormones (AKHs) are protein or peptide hormones that are important for sugar and fat homeostasis in metazoa. In insects, they mobilize sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis.


go_id: GO:0097004
term: adipokinetic hormone binding
ontology: MF
definition:
Binding to an adipokinetic hormone. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis.


go_id: GO:0097005
term: adipokinetic hormone receptor binding
ontology: MF
definition:
Binding to an adipokinetic hormone receptor. Adipokinetic hormones (AKHs) are peptide hormones that are involved in the mobilization of sugar and lipids from the insect fat body during energy-requiring activities such as flight and locomotion. They also contribute to hemolymph sugar homeostasis.


go_id: GO:0097006
term: regulation of plasma lipoprotein particle levels
ontology: BP
definition:
Any process involved in the maintenance of internal levels of plasma lipoprotein particles within an organism.


go_id: GO:0097007
term: 4,8,12-trimethyltrideca-1,3,7,11-tetraene synthase activity
ontology: MF
definition:
Catalysis of the reaction: (EE)-geranyllinalool + NADPH + O2 = 4,8,12-trimethyl-1,3,7,11-tridecatetraene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C18-farnesylacetone and then cleaved to produce 4,8,12-trimethyl-1,3,7,11-tridecatetraene (TMTT) and acetone.


go_id: GO:0097008
term: (3E)-4,8-dimethyl-1,3,7-nonatriene synthase activity
ontology: MF
definition:
Catalysis of the reaction: (E)-nerolidol + NADPH + O2 = (3E)-4,8-dimethylnona-1,3,7-triene + NADP+ + 2 H2O. It is unknown whether this reaction proceeds by the direct release of the 4-carbon compound but-1-en-3-one, or whether the substrate is first degraded to C11-geranylacetone and then cleaved to produce (3E)-4,8-dimethylnona-1,3,7-triene (DMNT) and acetone.


go_id: GO:0097010
term: eukaryotic translation initiation factor 4F complex assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form the eukaryotic translation initiation factor 4F complex.


go_id: GO:0097011
term: cellular response to granulocyte macrophage colony-stimulating factor stimulus
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.


go_id: GO:0097012
term: response to granulocyte macrophage colony-stimulating factor
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a granulocyte macrophage colony-stimulating factor stimulus.


go_id: GO:0097016
term: L27 domain binding
ontology: MF
definition:
Binding to a L27 domain of a protein. L27 is composed of conserved negatively charged amino acids and a conserved aromatic amino acid. L27 domains can assemble proteins involved in signaling and establishment and maintenance of cell polarity into complexes by interacting in a heterodimeric manner.


go_id: GO:0097017
term: renal protein absorption
ontology: BP
definition:
A renal system process in which proteins are taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures (e.g. protein absorption is observed in nephrocytes in Drosophila, see PMID:23264686).


go_id: GO:0097018
term: renal albumin absorption
ontology: BP
definition:
A renal system process in which albumin is taken up from the collecting ducts, glomerulus and proximal and distal loops of the nephron.


go_id: GO:0097020
term: COPII receptor activity
ontology: MF
definition:
Binding specifically to a substance (cargo) to deliver it to a COPII transport vesicle. Cargo receptors span a membrane (either the plasma membrane or a vesicle membrane), binding simultaneously to cargo molecules and coat adaptors, to efficiently recruit soluble proteins to nascent vesicles.


go_id: GO:0097021
term: lymphocyte migration into lymphoid organs
ontology: BP
definition:
The movement of a lymphocyte within the lymphatic system into lymphoid organs such as lymph nodes, spleen or Peyer's patches, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen.


go_id: GO:0097022
term: lymphocyte migration into lymph node
ontology: BP
definition:
The movement of a lymphocyte within the lymphatic system into a lymph node, and its subsequent positioning within defined functional compartments such as sites of cell activation by antigen.


go_id: GO:0097023
term: fructose 6-phosphate aldolase activity
ontology: MF
definition:
Catalysis of the reaction: D-fructose-6-phosphate = dihydroxyacetone + D-glyceraldehyde-3-phosphate.


go_id: GO:0097025
term: MPP7-DLG1-LIN7 complex
ontology: CC
definition:
A heterotrimeric protein complex formed by the association of MMP7, DLG1 and either LIN7A or LIN7C; regulates the stability and localization of DLG1 to cell junctions.


go_id: GO:0097026
term: dendritic cell dendrite assembly
ontology: BP
definition:
Formation of dendrites, branched cellular projections (or cytoplasmic extension) that are extended from the surface of a dendritic immune cell, and which enable the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells.


go_id: GO:0097027
term: ubiquitin-protein transferase activator activity
ontology: MF
definition:
Binds to and increases the activity of a ubiquitin-protein transferase, an enzyme that catalyzes the covalent attachment of ubiquitin to lysine in a substrate protein.


go_id: GO:0097028
term: dendritic cell differentiation
ontology: BP
definition:
The process in which a precursor cell type acquires the specialized features of a dendritic cell. A dendritic cell is a leukocyte of dendritic lineage specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.


go_id: GO:0097029
term: mature conventional dendritic cell differentiation
ontology: BP
definition:
The process in which antigen-activated dendritic cells acquire the specialized features of a mature conventional dendritic cell. Mature conventional dendritic cells upregulate the surface expression of MHC molecules, chemokine receptors and adhesion molecules, and increase the number of dendrites (cytoplasmic protrusions) in preparation for migration to lymphoid organs where they present antigen to T cells.


go_id: GO:0097030
term: CENP-A containing nucleosome binding
ontology: MF
definition:
Binding to a centromere-specific nucleosome, a form of nucleosome located only at the centromere, in which the histone H3 is replaced by the variant form CENP-A (sometimes known as CenH3).


go_id: GO:0097036
term: regulation of plasma membrane sterol distribution
ontology: BP
definition:
Any process that modulates the proportions or spatial arrangement of sterols in the plasma membrane.


go_id: GO:0097038
term: perinuclear endoplasmic reticulum
ontology: CC
definition:
The portion of endoplasmic reticulum, the intracellular network of tubules and cisternae, that occurs near the nucleus. The lumen of the perinuclear endoplasmic reticulum is contiguous with the nuclear envelope lumen (also called perinuclear space), the region between the inner and outer nuclear membranes.


go_id: GO:0097039
term: protein linear polyubiquitination
ontology: BP
definition:
A protein ubiquitination process in which a linear polymer of ubiquitin, formed by the amino-terminal methionine (M1) of one ubiquitin molecule and by the carboxy-terminal glycine (G76) of the next, is added to a protein.


go_id: GO:0097040
term: phthiocerol biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of phthiocerol, a lipid-based 1,3-glycol consisting of (3S,4R)-3-methoxy-4-methylnonacosane having (9R)- and (11S)-hydroxy substituents.


go_id: GO:0097041
term: phenolic phthiocerol biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of phenolic phthiocerol, a phthiocerol derivative having a 4-hydroxyphenyl substituent at the 29-position.


go_id: GO:0097042
term: extrinsic component of fungal-type vacuolar membrane
ontology: CC
definition:
The component of a fungal-type vacuolar membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0097043
term: histone H3-K56 acetylation
ontology: BP
definition:
The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone.


go_id: GO:0097044
term: histone H3-K56 acetylation in response to DNA damage
ontology: BP
definition:
The modification of histone H3 by the addition of an acetyl group to a lysine residue at position 56 of the histone as a result of the detection of DNA damage within a cell.


go_id: GO:0097045
term: phosphatidylserine exposure on blood platelet
ontology: BP
definition:
A phospholipid scrambling process that results in the appearance of phosphatidylserine on the surface of activated blood platelets, and triggers the clotting system.


go_id: GO:0097046
term: replication fork progression beyond termination site
ontology: BP
definition:
Regulation of DNA replication by a mechanism that allows a DNA replication fork to progress beyond a termination site, which is a region containing fork pausing elements that influence the progression and merging of DNA replication forks.


go_id: GO:0097047
term: DNA replication termination region
ontology: CC
definition:
A chromosomal region that contains fork pausing elements influencing the progression and merging of DNA replication forks.


go_id: GO:0097048
term: dendritic cell apoptotic process
ontology: BP
definition:
Any apoptotic process in a dendritic cell, a cell of hematopoietic origin, typically resident in particular tissues, specialized in the uptake, processing, and transport of antigens to lymph nodes for the purpose of stimulating an immune response via T cell activation.


go_id: GO:0097049
term: motor neuron apoptotic process
ontology: BP
definition:
Any apoptotic process in a motor neuron, an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.


go_id: GO:0097050
term: type B pancreatic cell apoptotic process
ontology: BP
definition:
Any apoptotic process in a type B pancreatic cell, a cell located towards center of the islets of Langerhans that secretes insulin.


go_id: GO:0097052
term: L-kynurenine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine).


go_id: GO:0097053
term: L-kynurenine catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of L-kynurenine, the L-enantiomer of the amino acid kynurenine (3-(2-aminobenzoyl)-alanine).


go_id: GO:0097054
term: L-glutamate biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of L-glutamate, the L enantiomer anion of 2-aminopentanedioic acid.


go_id: GO:0097055
term: agmatine biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of agmatine ((4-aminobutyl)guanidine, NH2-CH2-CH2-CH2-CH2-NH-C(-NH2)(=NH)). Agmatine is the decarboxylation product of the amino acid arginine and is an intermediate in polyamine biosynthesis. It is synthesized in the brain, stored in synaptic vesicles, accumulated by uptake, released by membrane depolarization, and inactivated by agmatinase.


go_id: GO:0097056
term: selenocysteinyl-tRNA(Sec) biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of selenocysteinyl-tRNA(Sec). This process occurs through the following steps: a unique serine-tRNA with a UGA recognizing anticodon is first aminoacylated with serine; this is then phosphorylated by phosphoseryl-tRNA[Ser]Sec kinase; lastly, selenium is swapped for the phosphate on the serine.


go_id: GO:0097057
term: TRAF2-GSTP1 complex
ontology: CC
definition:
A protein complex comprising tumor necrosis factor (TNF) receptor-associated factor 2 (TRAF2) and glutathione S-transferase pi 1 (GSTP1). This complex is thought to disrupt the TNF signaling cascade, thus down-regulating inflammatory responses.


go_id: GO:0097058
term: CRLF-CLCF1 complex
ontology: CC
definition:
A heterodimeric protein complex that is composed of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene) and cytokine receptor-like factor 1 (product of the CRLF gene) and is secreted into the extracellular space. The CRLF-CLCF1 complex is a ligand for the ciliary neurotrophic factor (CNTF) receptor complex.


go_id: GO:0097059
term: CNTFR-CLCF1 complex
ontology: CC
definition:
A protein complex that is composed of two soluble ciliary neurotrophic factor receptor alpha subunits (product of the CNTFR gene) and two molecules of cardiotrophin-like cytokine factor 1 (product of the CLCF1 gene). The complex is secreted into the extracellular space.


go_id: GO:0097060
term: synaptic membrane
ontology: CC
definition:
A specialized area of membrane on either the presynaptic or the postsynaptic side of a synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.


go_id: GO:0097061
term: dendritic spine organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a dendritic spine. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.


go_id: GO:0097062
term: dendritic spine maintenance
ontology: BP
definition:
The organization process that preserves a dendritic spine in a stable functional or structural state. A dendritic spine is a specialized protrusion from a neuronal dendrite and is involved in synaptic transmission.


go_id: GO:0097063
term: cadmium ion sensor activity
ontology: MF
definition:
Binding to and responding, e.g. by conformational change, to changes in the cellular level of cadmium (Cd++).


go_id: GO:0097065
term: anterior head development
ontology: BP
definition:
The process whose specific outcome is the progression of the anterior part of the head over time, from its formation to the mature structure.


go_id: GO:0097066
term: response to thyroid hormone
ontology: BP
definition:
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.


go_id: GO:0097067
term: cellular response to thyroid hormone stimulus
ontology: BP
definition:
A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroid hormone stimulus.


go_id: GO:0097068
term: response to thyroxine
ontology: BP
definition:
A change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus.


go_id: GO:0097069
term: cellular response to thyroxine stimulus
ontology: BP
definition:
A change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a thyroxine stimulus.


go_id: GO:0097070
term: ductus arteriosus closure
ontology: BP
definition:
The morphogenesis process in which the ductus arteriosus changes to no longer permit blood flow after birth. The ductus arteriosus is the shunt between the aorta and the pulmonary artery which allows blood to bypass the fetus' lungs.


go_id: GO:0097071
term: interferon regulatory factor complex
ontology: CC
definition:
A protein complex that consists of two interferon regulatory proteins (IRFs); may be homodimeric or heterodimeric. The activation of a latent closed conformation of IRF in the cytoplasm is triggered by phosphorylation of Ser/Thr residues in a C-terminal region. Phosphorylation stimulates the C-terminal autoinhibitory domain to attain a highly extended conformation triggering dimerization through extensive contacts to a second subunit.


go_id: GO:0097072
term: interferon regulatory factor 3 complex
ontology: CC
definition:
An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 3.


go_id: GO:0097073
term: interferon regulatory factor 5 complex
ontology: CC
definition:
An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 5.


go_id: GO:0097074
term: interferon regulatory factor 7 complex
ontology: CC
definition:
An interferon regulatory factor complex that consists of a homodimer of interferon regulatory factor 7.


go_id: GO:0097075
term: interferon regulatory factor 3-interferon regulatory factor 7 complex
ontology: CC
definition:
An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 7.


go_id: GO:0097076
term: transforming growth factor beta activated kinase 1 complex
ontology: CC
definition:
A protein complex that possesses protein kinase activity and activates the I-kappa B kinase complex (IKK) and mitogen-activated protein (MAP) kinases in response to TRAF6 signaling. It comprises the catalytic subunit TAK1 complexed to the regulatory subunits, termed TABs (TAK1-binding subunits).


go_id: GO:0097077
term: copper ion sensor activity
ontology: MF
definition:
Binding to and responding, e.g. by conformational change, to changes in the cellular level of copper(I) (Cu+).


go_id: GO:0097078
term: FAL1-SGD1 complex
ontology: CC
definition:
A protein complex involved in the 18S rRNA biogenesis. In S. cerevisiae this complex consists of Fal1p and Sgd1p and in humans this complex consists of NOM1 and eIF4AIII subunits.


go_id: GO:0097079
term: selenite:proton symporter activity
ontology: MF
definition:
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: selenite(out) + H+(out) = selenite(in) + H+(in).


go_id: GO:0097081
term: vascular associated smooth muscle cell fate commitment
ontology: BP
definition:
The commitment of cells to a vascular smooth muscle cell fate and their capacity to differentiate into vascular smooth muscle cells. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.


go_id: GO:0097082
term: vascular associated smooth muscle cell fate specification
ontology: BP
definition:
The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell in an environment that is neutral with respect to the developmental pathway. Upon specification, the cell fate can be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.


go_id: GO:0097083
term: vascular associated smooth muscle cell fate determination
ontology: BP
definition:
The process in which a cell becomes capable of differentiating autonomously into a vascular smooth muscle cell regardless of its environment; upon determination, the cell fate cannot be reversed. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.


go_id: GO:0097084
term: vascular associated smooth muscle cell development
ontology: BP
definition:
The process aimed at the progression of a vascular smooth muscle cell over time, from initial commitment of the cell to a specific fate, to the fully functional differentiated cell. A vascular smooth muscle cell is a non-striated, elongated, spindle-shaped cell found lining the blood vessels.


go_id: GO:0097085
term: interferon regulatory factor 3-interferon regulatory factor 5 complex
ontology: CC
definition:
An interferon regulatory factor complex that consists of a heterodimer of interferon regulatory factor 3 and interferon regulatory factor 5.


go_id: GO:0097086
term: amniotic stem cell differentiation
ontology: BP
definition:
The process whereby a relatively unspecialized cell acquires specialized features of an amniotic stem cell. An amniotic stem cell is a mesenchymal stem cell extracted from amniotic fluid. Amniotic stem cells are able to differentiate into various tissue types such as skin, cartilage, cardiac tissue, nerves, muscle, and bone.


go_id: GO:0097087
term: interleukin-17A production
ontology: BP
definition:
The appearance of interleukin-17A due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0097088
term: interleukin-17F production
ontology: BP
definition:
The appearance of interleukin-17F due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0097089
term: methyl-branched fatty acid metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving methyl-branched fatty acids, aliphatic monocarboxylic acids with methyl branches on the main chain.


go_id: GO:0097090
term: presynaptic membrane organization
ontology: BP
definition:
A process which results in the assembly, arrangement of constituent parts, or disassembly of a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.


go_id: GO:0097092
term: polyacyltrehalose metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving polyacyltrehalose, a pentaacylated, trehalose-based glycolipid.


go_id: GO:0097093
term: polyacyltrehalose biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of polyacyltrehalose, a pentaacylated, trehalose-based glycolipid.


go_id: GO:0097095
term: frontonasal suture morphogenesis
ontology: BP
definition:
The process in which the frontonasal suture, between frontal and nasal bones, is generated and organized.


go_id: GO:0097098
term: DNA/RNA hybrid annealing activity
ontology: MF
definition:
An activity that facilitates the base-pairing of single-stranded RNA to double-stranded DNA resulting in the formation of R-loops.


go_id: GO:0097099
term: structural constituent of albumen
ontology: MF
definition:
The action of a molecule that contributes to the structural integrity of albumen (also called egg white). Albumen is the clear liquid contained within an egg and consists of water and proteins, among which are ovomucin and ovomucoid. It protects the egg yolk and provides additional nutrition for the growth of the embryo.


go_id: GO:0097100
term: supercoiled DNA binding
ontology: MF
definition:
Binding to supercoiled DNA. For example, during replication and transcription, template DNA is negatively supercoiled in the receding downstream DNA and positively supercoiled in the approaching downstream DNA.


go_id: GO:0097101
term: blood vessel endothelial cell fate specification
ontology: BP
definition:
The process involved in the specification of identity of a blood vessel endothelial cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. A blood vessel endothelial cell is an endothelial cell of the vascular tree, which includes blood vessels and lymphatic vessels.


go_id: GO:0097102
term: endothelial tip cell fate specification
ontology: BP
definition:
The process involved in the specification of identity of an endothelial tip cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial tip cell is a specialized endothelial cell localized to the leading edge of an angiogenic sprout that senses extracellular signals and guides the directed growth of blood vessels.


go_id: GO:0097103
term: endothelial stalk cell fate specification
ontology: BP
definition:
The process involved in the specification of identity of an endothelial stalk cell. Once specification has taken place, a cell will be committed to differentiate down a specific pathway if left in its normal environment. An endothelial stalk cell is a specialized endothelial cell which follows behind the tip cell of an angiogenic sprout.


go_id: GO:0097104
term: postsynaptic membrane assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a postsynaptic membrane, a specialized area of membrane facing the presynaptic membrane on the tip of the nerve ending and separated from it by a minute cleft (the synaptic cleft).


go_id: GO:0097105
term: presynaptic membrane assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a presynaptic membrane, including any proteins associated with the membrane, but excluding other cellular components. A presynaptic membrane is a  specialized area of membrane of the axon terminal that faces the plasma membrane of the neuron or muscle fiber with which the axon terminal establishes a synaptic junction.


go_id: GO:0097106
term: postsynaptic density organization
ontology: BP
definition:
A process that results in the assembly, arrangement of constituent parts, or disassembly of a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.


go_id: GO:0097107
term: postsynaptic density assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a postsynaptic density, a region that lies adjacent to the cytoplasmic face of the postsynaptic membrane at excitatory synapse.


go_id: GO:0097109
term: neuroligin family protein binding
ontology: MF
definition:
Binding to a member of the neuroligin protein family, neuronal cell surface proteins that mediate synapse formation.


go_id: GO:0097110
term: scaffold protein binding
ontology: MF
definition:
Binding to a scaffold protein. Scaffold proteins are crucial regulators of many key signaling pathways. Although not strictly defined in function, they are known to interact and/or bind with multiple members of a signaling pathway, tethering them into complexes.


go_id: GO:0097111
term: endoplasmic reticulum-Golgi intermediate compartment organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of the endoplasmic reticulum (ER)-Golgi intermediate compartment.


go_id: GO:0097112
term: gamma-aminobutyric acid receptor clustering
ontology: BP
definition:
The receptor clustering process in which gamma-aminobutyric acid (GABA) receptors are localized to distinct domains in the cell membrane.


go_id: GO:0097113
term: AMPA glutamate receptor clustering
ontology: BP
definition:
The glutamate receptor clustering process in which alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate (AMPA) receptors are localized to distinct domains in the cell membrane.


go_id: GO:0097114
term: NMDA glutamate receptor clustering
ontology: BP
definition:
The receptor clustering process in which N-methyl-D-aspartate (NMDA) receptors are localized to distinct domains in the cell membrane.


go_id: GO:0097115
term: neurexin clustering involved in presynaptic membrane assembly
ontology: BP
definition:
The receptor clustering process involved in assembly of the presynaptic membrane in which neurexins are localized to distinct domains in the cell membrane. Neurexins are synaptic cell surface proteins which act as cell recognition molecules at nerve terminals.


go_id: GO:0097116
term: gephyrin clustering involved in postsynaptic density assembly
ontology: BP
definition:
The clustering process in which gephyrin molecules are localized to distinct domains in the postsynaptic density as part of postsynaptic density assembly. Gephyrin is a component of the postsynaptic protein network of inhibitory synapses.


go_id: GO:0097117
term: guanylate kinase-associated protein clustering
ontology: BP
definition:
The clustering process in which guanylate kinase-associated proteins (GKAPs) are localized to distinct domains in the cell membrane. GKAP facilitates assembly of the post synaptic density of neurons.


go_id: GO:0097118
term: neuroligin clustering involved in postsynaptic membrane assembly
ontology: BP
definition:
The receptor clustering process involved in assembly of the postsynaptic membrane in which neuroligins are localized to distinct domains in the cell membrane. Neuroligins are neuronal cell surface proteins on the postsynaptic membrane that mediate synapse formation between neurons.


go_id: GO:0097119
term: postsynaptic density protein 95 clustering
ontology: BP
definition:
The clustering process in which postsynaptic density protein 95 (PSD-95) molecules are localized to distinct domains in the cell membrane. PSD-95 is mostly located in the post synaptic density of neurons, and is involved in anchoring synaptic proteins.


go_id: GO:0097120
term: receptor localization to synapse
ontology: BP
definition:
Any process in which a receptor is transported to, and/or maintained at the synapse, the junction between a nerve fiber of one neuron and another neuron or muscle fiber or glial cell.


go_id: GO:0097121
term: cyclin A1-CDK1 complex
ontology: CC
definition:
A protein complex consisting of cyclin A1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


go_id: GO:0097122
term: cyclin A2-CDK1 complex
ontology: CC
definition:
A protein complex consisting of cyclin A2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


go_id: GO:0097123
term: cyclin A1-CDK2 complex
ontology: CC
definition:
A protein complex consisting of cyclin A1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


go_id: GO:0097124
term: cyclin A2-CDK2 complex
ontology: CC
definition:
A protein complex consisting of cyclin A2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


go_id: GO:0097125
term: cyclin B1-CDK1 complex
ontology: CC
definition:
A protein complex consisting of cyclin B1 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


go_id: GO:0097126
term: cyclin B2-CDK1 complex
ontology: CC
definition:
A protein complex consisting of cyclin B2 and cyclin-dependent kinase 1 (CDK1). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


go_id: GO:0097127
term: cyclin B3-CDK2 complex
ontology: CC
definition:
A protein complex consisting of cyclin B3 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


go_id: GO:0097128
term: cyclin D1-CDK4 complex
ontology: CC
definition:
A protein complex consisting of cyclin D1 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


go_id: GO:0097129
term: cyclin D2-CDK4 complex
ontology: CC
definition:
A protein complex consisting of cyclin D2 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


go_id: GO:0097130
term: cyclin D3-CDK4 complex
ontology: CC
definition:
A protein complex consisting of cyclin D3 and cyclin-dependent kinase 4 (CDK4). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


go_id: GO:0097131
term: cyclin D1-CDK6 complex
ontology: CC
definition:
A protein complex consisting of cyclin D1 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


go_id: GO:0097132
term: cyclin D2-CDK6 complex
ontology: CC
definition:
A protein complex consisting of cyclin D2 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


go_id: GO:0097133
term: cyclin D3-CDK6 complex
ontology: CC
definition:
A protein complex consisting of cyclin D3 and cyclin-dependent kinase 6 (CDK6). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


go_id: GO:0097134
term: cyclin E1-CDK2 complex
ontology: CC
definition:
A protein complex consisting of cyclin E1 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


go_id: GO:0097135
term: cyclin E2-CDK2 complex
ontology: CC
definition:
A protein complex consisting of cyclin E2 and cyclin-dependent kinase 2 (CDK2). Cyclins are characterized by periodicity in protein abundance throughout the cell cycle. Cyclin-dependent kinases represent a family of serine/threonine protein kinases that become active upon binding to a cyclin regulatory partner.


go_id: GO:0097136
term: Bcl-2 family protein complex
ontology: CC
definition:
A protein complex that consists of members of the Bcl-2 family of anti- and proapoptotic regulators. Bcl-2 proteins respond to cues from various forms of intracellular stress, such as DNA damage or cytokine deprivation, and interact with opposing family members to determine whether or not the caspase proteolytic cascade should be unleashed.


go_id: GO:0097137
term: BAD-BCL-xl complex
ontology: CC
definition:
A heterodimeric protein complex consisting of BAD and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.


go_id: GO:0097138
term: BAD-BCL-2 complex
ontology: CC
definition:
A heterodimeric protein complex consisting of BAD and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.


go_id: GO:0097139
term: BID-BCL-2 complex
ontology: CC
definition:
A heterodimeric protein complex consisting of BID and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.


go_id: GO:0097140
term: BIM-BCL-xl complex
ontology: CC
definition:
A heterodimeric protein complex consisting of BIM and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.


go_id: GO:0097141
term: BIM-BCL-2 complex
ontology: CC
definition:
A heterodimeric protein complex consisting of BIM and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.


go_id: GO:0097142
term: PUMA-BCL-2 complex
ontology: CC
definition:
A heterodimeric protein complex consisting of PUMA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.


go_id: GO:0097143
term: PUMA-BCL-xl complex
ontology: CC
definition:
A heterodimeric protein complex consisting of PUMA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.


go_id: GO:0097144
term: BAX complex
ontology: CC
definition:
An oligomeric protein complex consisting of BAX, a member of the Bcl-2 family of anti- and proapoptotic regulators.


go_id: GO:0097145
term: BAK complex
ontology: CC
definition:
An oligomeric protein complex consisting of BAK, a member of the Bcl-2 family of anti- and proapoptotic regulators.


go_id: GO:0097146
term: NOXA-BCL-xl complex
ontology: CC
definition:
A heterodimeric protein complex consisting of NOXA and BCL-xl, members of the Bcl-2 family of anti- and proapoptotic regulators.


go_id: GO:0097147
term: NOXA-BCL-2 complex
ontology: CC
definition:
A heterodimeric protein complex consisting of NOXA and BCL-2, members of the Bcl-2 family of anti- and proapoptotic regulators.


go_id: GO:0097148
term: BCL-2 complex
ontology: CC
definition:
A homodimeric protein complex consisting of BCL-2, a member of the Bcl-2 family of anti- and proapoptotic regulators.


go_id: GO:0097149
term: centralspindlin complex
ontology: CC
definition:
A heterotetrameric protein complex playing a key role in the formation of the central spindle in mitosis. Made up of two molecules each of a mitotic kinesin (ZEN-4 in Caenorhabditis elegans or MKLP1 in mammals) and of two molecules each of a GTPase activating protein (GAP) factor (CYK-4 in Caenorhabditis elegans or MgcRacGAP in mammals).


go_id: GO:0097151
term: positive regulation of inhibitory postsynaptic potential
ontology: BP
definition:
Any process that activates or increases the frequency, rate or extent of inhibitory postsynaptic potential (IPSP). IPSP is a temporary decrease in postsynaptic membrane potential due to the flow of negatively charged ions into the postsynaptic cell. The flow of ions that causes an IPSP is an inhibitory postsynaptic current (IPSC) and makes it more difficult for the neuron to fire an action potential.


go_id: GO:0097152
term: mesenchymal cell apoptotic process
ontology: BP
definition:
Any apoptotic process in a mesenchymal cell. A mesenchymal cell is a loosely associated cell that is part of the connective tissue in an organism. Mesenchymal cells give rise to more mature connective tissue cell types.


go_id: GO:0097153
term: cysteine-type endopeptidase activity involved in apoptotic process
ontology: MF
definition:
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic process.


go_id: GO:0097154
term: GABAergic neuron differentiation
ontology: BP
definition:
The process in which a neuroblast acquires the specialized structural and functional features of a GABAergic neuron.


go_id: GO:0097159
term: organic cyclic compound binding
ontology: MF
definition:
Binding to an organic cyclic compound, any molecular entity that contains carbon arranged in a cyclic molecular structure.


go_id: GO:0097160
term: polychlorinated biphenyl binding
ontology: MF
definition:
Binding to a polychlorinated biphenyl (PCB), a biphenyl compound containing between 2 and 10 chlorine atoms attached to the two benzene rings.


go_id: GO:0097161
term: DH domain binding
ontology: MF
definition:
Binding to a DH (Dbl homology) domain of a protein. The DH domain contains three structurally conserved regions separated by more variable regions. It is composed of 11 alpha helices that are folded into a flattened, elongated alpha-helix bundle in which two of the three conserved regions, conserved region 1 (CR1) and conserved region 3 (CR3), are exposed near the centre of one surface. CR1 and CR3, together with a part of alpha-6 and the DH/PH (pleckstrin homology) junction site, constitute the Rho GTPase interacting pocket.


go_id: GO:0097162
term: MADS box domain binding
ontology: MF
definition:
Binding to a MADS box domain, a protein domain that encodes the DNA-binding MADS domain. The MADS domain binds to DNA sequences of high similarity to the motif CC[A/T]6GG termed the CArG-box. MADS-domain proteins are generally transcription factors. The length of the MADS-box is in the range of 168 to 180 base pairs.


go_id: GO:0097165
term: nuclear stress granule
ontology: CC
definition:
A dense aggregation in the nucleus composed of proteins and RNAs that appear when the cell is under stress.


go_id: GO:0097166
term: lens epithelial cell proliferation
ontology: BP
definition:
The multiplication or reproduction of lens epithelial cells, resulting in the expansion of a cell population. Lens epithelial cells make up the lens epithelium, which is located in the anterior portion of the lens between the lens capsule and the lens fibers and is a simple cuboidal epithelium. The epithelial cells of the lens regulate most of the homeostatic functions of the lens such as osmolarity and liquid volume. The lens epithelial cells also serve as the progenitors for new lens fibers. The lens epithelium constantly lays down fibers in the embryo, fetus, infant, and adult, and continues to lay down fibers for lifelong growth.


go_id: GO:0097167
term: circadian regulation of translation
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of mRNA translation with a regularity of approximately 24 hours.


go_id: GO:0097168
term: mesenchymal stem cell proliferation
ontology: BP
definition:
The multiplication or reproduction of mesenchymal stem cells, resulting in the expansion of a stem cell population. A mesenchymal stem cell, or MSC, is a cell that retains the ability to divide and proliferate throughout life to provide progenitor cells that can differentiate into specialized mesenchymal cells.


go_id: GO:0097169
term: AIM2 inflammasome complex
ontology: CC
definition:
An inflammasome complex that consists of AIM2, ASC, and caspase-1. AIM2 is a member of the HN-200 protein family that appears to be the sensor of cytosolic double-stranded DNA.


go_id: GO:0097170
term: ADP-L-glycero-beta-D-manno-heptose metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate.


go_id: GO:0097171
term: ADP-L-glycero-beta-D-manno-heptose biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of ADP-L-glycero-beta-D-manno-heptose, an ADP-L-glycero-D-manno-heptose having beta-configuration at the anomeric centre of the heptose. ADP-L-glycero-beta-D-manno-heptose (also called ADP-L-beta-D-heptose or ADP-L-glycero-D-manno-heptose) is a nucleotide-sugar precursor of the inner core lipopolysaccharide (LPS) from D-glycero-beta-D-manno-heptose 7-phosphate.


go_id: GO:0097172
term: N-acetylmuramic acid metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine.


go_id: GO:0097173
term: N-acetylmuramic acid catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of N-acetylmuramic acid (MurNAc), a monosaccharide derivative of N-acetylglucosamine.


go_id: GO:0097174
term: 1,6-anhydro-N-acetyl-beta-muramic acid metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving 1,6-anhydro-N-acetyl-beta-muramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid.


go_id: GO:0097175
term: 1,6-anhydro-N-acetyl-beta-muramic acid catabolic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the breakdown of 1,6-anhydro-N-acetylmuramic acid, the 1,6-anhydro-derivative of N-acetyl-beta-muramic acid.


go_id: GO:0097176
term: epoxide metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving epoxides, compounds in which an oxygen atom is directly attached to two adjacent or non-adjacent carbon atoms of a carbon chain or ring system; thus cyclic ethers.


go_id: GO:0097178
term: ruffle assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a ruffle, a projection at the leading edge of a crawling cell; the protrusions are supported by a microfilament meshwork. The formation of ruffles (also called membrane ruffling) is thought to be controlled by a group of enzymes known as Rho GTPases, specifically RhoA, Rac1 and cdc42.


go_id: GO:0097179
term: protease inhibitor complex
ontology: CC
definition:
A heterodimeric protein complex that contains a protease inhibitor and a protease; formation of the complex inhibits protease activity.


go_id: GO:0097180
term: serine protease inhibitor complex
ontology: CC
definition:
A heterodimeric protein complex that contains a serine protease inhibitor and a protease; formation of the complex inhibits serine protease activity.


go_id: GO:0097181
term: protein C inhibitor-coagulation factor V complex
ontology: CC
definition:
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor V (F5); formation of the complex inhibits the serine protease activity of coagulation factor V.


go_id: GO:0097182
term: protein C inhibitor-coagulation factor Xa complex
ontology: CC
definition:
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor Xa (F10); formation of the complex inhibits the serine protease activity of coagulation factor Xa.


go_id: GO:0097183
term: protein C inhibitor-coagulation factor XI complex
ontology: CC
definition:
A heterodimeric protein complex that contains protein C inhibitor (SERPINA5) and coagulation factor XI (F11); formation of the complex inhibits the serine protease activity of coagulation factor XI.


go_id: GO:0097184
term: response to azide
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus.


go_id: GO:0097185
term: cellular response to azide
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an azide stimulus.


go_id: GO:0097186
term: amelogenesis
ontology: BP
definition:
The process whose specific outcome is the formation of tooth enamel, occurring in two stages: secretory stage and maturation stage.


go_id: GO:0097187
term: dentinogenesis
ontology: BP
definition:
The process whose specific outcome is the formation of dentin, the mineralized tissue that constitutes the major bulk of teeth. Dentin may be one of three types: primary dentin, secondary dentin, and tertiary dentin.


go_id: GO:0097188
term: dentin mineralization
ontology: BP
definition:
The process in which calcium salts are deposited into the calcareous tooth structure known as dentin.


go_id: GO:0097189
term: apoptotic body
ontology: CC
definition:
A vesicle containing parts of a dying cell. Apoptotic bodies can be formed during the execution phase of the apoptotic process, when the cell's cytoskeleton breaks up and causes the membrane to bulge outward. These bulges may separate from the cell, taking a portion of cytoplasm with them, to become apoptotic bodies. These are then engulfed by phagocytic cells, and their components recycled. Apoptotic bodies may range in size from 0.8 to 5um.


go_id: GO:0097190
term: apoptotic signaling pathway
ontology: BP
definition:
The series of molecular signals which triggers the apoptotic death of a cell. The pathway starts with reception of a signal, and ends when the execution phase of apoptosis is triggered.


go_id: GO:0097191
term: extrinsic apoptotic signaling pathway
ontology: BP
definition:
The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with either a ligand binding to a cell surface receptor, or a ligand being withdrawn from a cell surface receptor (e.g. in the case of signaling by dependence receptors), and ends when the execution phase of apoptosis is triggered.


go_id: GO:0097192
term: extrinsic apoptotic signaling pathway in absence of ligand
ontology: BP
definition:
The series of molecular signals in which a signal is conveyed from the cell surface to trigger the apoptotic death of a cell. The pathway starts with withdrawal of a ligand from a cell surface receptor, and ends when the execution phase of apoptosis is triggered.


go_id: GO:0097193
term: intrinsic apoptotic signaling pathway
ontology: BP
definition:
The series of molecular signals in which an intracellular signal is conveyed to trigger the apoptotic death of a cell. The pathway starts with reception of an intracellular signal (e.g. DNA damage, endoplasmic reticulum stress, oxidative stress etc.), and ends when the execution phase of apoptosis is triggered. The intrinsic apoptotic signaling pathway is crucially regulated by permeabilization of the mitochondrial outer membrane (MOMP).


go_id: GO:0097194
term: execution phase of apoptosis
ontology: BP
definition:
A stage of the apoptotic process that starts with the controlled breakdown of the cell through the action of effector caspases or other effector molecules (e.g. cathepsins, calpains etc.). Key steps of the execution phase are rounding-up of the cell, retraction of pseudopodes, reduction of cellular volume (pyknosis), chromatin condensation, nuclear fragmentation (karyorrhexis), plasma membrane blebbing and fragmentation of the cell into apoptotic bodies. When the execution phase is completed, the cell has died.


go_id: GO:0097195
term: pilomotor reflex
ontology: BP
definition:
The reflex process in which the arrectores pilorum (hair follicle) muscles contract and cause the hair to stand erect.


go_id: GO:0097196
term: Shu complex
ontology: CC
definition:
A protein complex involved in error-free DNA post-replication repair (PRR). In Saccharomyces cerevisiae the complex contains Csm2p, Psy3p, Shu1p, and Shu2p.


go_id: GO:0097197
term: tetraspanin-enriched microdomain
ontology: CC
definition:
A pre-organized unit composed either of adhesion molecules (mainly integrins and members of the Ig superfamily), signaling receptors and/or enzyme-enriched plasma membrane domains that compartmentalizes cellular processes. Tetraspanin-enriched microdomains might be specially suited for the regulation of avidity of adhesion receptors and the compartmentalization of enzymatic activities.


go_id: GO:0097198
term: histone H3-K36 trimethylation
ontology: BP
definition:
The modification of histone H3 by addition of three methyl groups to lysine at position 36 of the histone.


go_id: GO:0097199
term: cysteine-type endopeptidase activity involved in apoptotic signaling pathway
ontology: MF
definition:
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the apoptotic signaling pathway.


go_id: GO:0097200
term: cysteine-type endopeptidase activity involved in execution phase of apoptosis
ontology: MF
definition:
Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which the sulfhydryl group of a cysteine residue at the active center acts as a nucleophile, and contributing to the execution phase of apoptosis.


go_id: GO:0097201
term: negative regulation of transcription from RNA polymerase II promoter in response to stress
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of transcription from an RNA polymerase II promoter as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).


go_id: GO:0097203
term: phagocytic cup lip
ontology: CC
definition:
The tip or margin of the progressing circular lamella that engulfs a particle during phagocytosis. When the two lips of the cup fuse it is converted into a phagosome.


go_id: GO:0097204
term: phagocytic cup base
ontology: CC
definition:
The older part of the phagocytic cup where the actin cytoskeleton disassembles, allowing early incoming and outgoing vesicular trafficking.


go_id: GO:0097205
term: renal filtration
ontology: BP
definition:
A renal system process in which fluid circulating through the body is filtered through a barrier system.


go_id: GO:0097206
term: nephrocyte filtration
ontology: BP
definition:
The process by which hemolymph is filtered based on size and charge through a nephrocyte filtration barrier formed by the basement membrane and nephrocyte diaphragm.


go_id: GO:0097207
term: bud dormancy process
ontology: BP
definition:
A dormancy process in which dormancy (sometimes called a dormant state) is induced, maintained or broken in a bud. Bud dormancy is a suspension of most physiological activity and growth that can be reactivated. It may be a response to environmental conditions such as seasonality or extreme heat, drought, or cold. The exit from bud dormancy is marked by the resumed growth of the bud.


go_id: GO:0097208
term: alveolar lamellar body
ontology: CC
definition:
A specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.


go_id: GO:0097209
term: epidermal lamellar body
ontology: CC
definition:
A specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function.


go_id: GO:0097210
term: response to gonadotropin-releasing hormone
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.


go_id: GO:0097211
term: cellular response to gonadotropin-releasing hormone
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a gonadotropin-releasing hormone stimulus. Gonadotropin-releasing hormone (GnRH) is a peptide hormone responsible for the release of follicle-stimulating hormone (FSH) and luteinizing hormone (LH) from the anterior pituitary. GnRH is synthesized and released by the hypothalamus.


go_id: GO:0097212
term: lysosomal membrane organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lysosomal membrane. A lysosomal membrane is the lipid bilayer surrounding the lysosome and separating its contents from the cell cytoplasm.


go_id: GO:0097213
term: regulation of lysosomal membrane permeability
ontology: BP
definition:
Any process that modulates the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane.


go_id: GO:0097214
term: positive regulation of lysosomal membrane permeability
ontology: BP
definition:
Any process that increases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane.


go_id: GO:0097215
term: negative regulation of lysosomal membrane permeability
ontology: BP
definition:
Any process that decreases the frequency, rate or extent of the passage or uptake of molecules by the lysosomal membrane.


go_id: GO:0097216
term: guanosine tetraphosphate binding
ontology: MF
definition:
Binding to guanosine tetraphosphate (5'-ppGpp-3'), a guanosine bisphosphate having diphosphate groups at both the 3' and 5'-positions.


go_id: GO:0097217
term: sieve area
ontology: CC
definition:
A pit-like area in the cell wall of a sieve element; contains pores lined with callose and occupied by strands of protoplasmic material that interconnect the protoplasts of contiguous sieve elements.


go_id: GO:0097218
term: sieve plate
ontology: CC
definition:
A part of the cell wall of a sieve tube member that bears one or more highly specialized sieve areas.


go_id: GO:0097219
term: compound sieve plate
ontology: CC
definition:
A sieve plate that contains several specialized sieve areas in either a scalariform or reticulate arrangement.


go_id: GO:0097221
term: M/G1 phase-specific MADS box-forkhead transcription factor complex
ontology: CC
definition:
A protein complex that contains a MADS-box protein and two forkhead domain proteins, and binds to and regulates transcription from promoters of genes transcribed during the M/G1 transition of the cell cycle. In Schizosaccharomyces pombe, the complex contains the MADS-box protein Mbx1 and two forkhead proteins, Sep1 and Fkh2.


go_id: GO:0097222
term: mitochondrial mRNA polyadenylation
ontology: BP
definition:
The enzymatic addition of a sequence of 40-60 adenylyl residues at the 3' end of a eukaryotic mitochondrial mRNA primary transcript. Mitochondria contain both stabilizing and destabilizing poly(A) tails.


go_id: GO:0097224
term: sperm connecting piece
ontology: CC
definition:
The segment of the sperm flagellum that attaches to the implantation fossa of the nucleus in the sperm head; from the remnant of the centriole at this point, the axoneme extends throughout the length of the flagellum.


go_id: GO:0097225
term: sperm midpiece
ontology: CC
definition:
The highly organized segment of the sperm flagellum which begins at the connecting piece and is characterized by the presence of 9 outer dense fibers (ODFs) that lie outside each of the 9 outer axonemal microtubule doublets and by a sheath of mitochondria that encloses the ODFs and the axoneme; the midpiece terminates about one-fourth of the way down the sperm flagellum at the annulus, which marks the beginning of the principal piece.


go_id: GO:0097226
term: sperm mitochondrial sheath
ontology: CC
definition:
The tightly packed helical sheath of ATP-producing mitochondria restricted to the midpiece of the sperm flagellum.


go_id: GO:0097227
term: sperm annulus
ontology: CC
definition:
The ring-like, filamentous structure located at the distal end of the midpiece of the sperm flagellum; the annulus is thought to form a diffusion barrier between the midpiece and the principal piece and serve as a stabilizing structure for tail rigidity.


go_id: GO:0097228
term: sperm principal piece
ontology: CC
definition:
The segment of the sperm flagellum where the mitochondrial sheath ends, and the outer dense fibers (ODFs) associated with outer axonemal doublets 3 and 8 are replaced by the 2 longitudinal columns of the fibrous sheath (FS) which run the length of the principal piece and are stabilized by circumferential ribs. The principal piece makes up ~2/3 of the length of the sperm flagellum and is defined by the presence of the FS and of only 7 (rather than 9) ODFs which taper and then terminate near the distal end of the principal piece.


go_id: GO:0097229
term: sperm end piece
ontology: CC
definition:
The short tip of the sperm flagellum, adjacent to the sperm principal piece and furthest from the sperm head, which contains only the axoneme surrounded by the plasma membrane.


go_id: GO:0097230
term: cell motility in response to potassium ion
ontology: BP
definition:
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a potassium ion stimulus.


go_id: GO:0097231
term: cell motility in response to calcium ion
ontology: BP
definition:
Any process involved in the controlled self-propelled movement of a cell that results in translocation of the cell from one place to another as a result of a calcium ion stimulus.


go_id: GO:0097232
term: lamellar body membrane
ontology: CC
definition:
The lipid bilayer surrounding a lamellar body. A lamellar body is a membrane-bounded organelle, specialized for the storage and secretion of various substances (surfactant phospholipids, glycoproteins and acid phosphates) which are arranged in the form of tightly packed, concentric, membrane sheets or lamellae. Has some similar properties to, but is distinct from, a lysosome.


go_id: GO:0097233
term: alveolar lamellar body membrane
ontology: CC
definition:
The lipid bilayer surrounding an alveolar lamellar body, a specialized secretory organelle found in type II pneumocytes and involved in the synthesis, secretion, and reutilization of pulmonary surfactant.


go_id: GO:0097234
term: epidermal lamellar body membrane
ontology: CC
definition:
The lipid bilayer surrounding an epidermal lamellar body, a specialized secretory organelle found in keratinocytes and involved in the formation of an impermeable, lipid-containing membrane that serves as a water barrier and is required for correct skin barrier function.


go_id: GO:0097237
term: cellular response to toxic substance
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a toxic stimulus.


go_id: GO:0097238
term: cellular response to methylglyoxal
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a methylglyoxal stimulus. Methylglyoxal is a 2-oxoaldehyde derived from propanal.


go_id: GO:0097239
term: positive regulation of transcription from RNA polymerase II promoter in response to methylglyoxal
ontology: BP
definition:
Any process that increases the frequency, rate or extent of transcription from an RNA polymerase II promoter in response to a methylglyoxal stimulus.


go_id: GO:0097241
term: hematopoietic stem cell migration to bone marrow
ontology: BP
definition:
The orderly movement of a hematopoietic stem cell into the bone marrow, and its subsequent positioning within defined functional compartments in that microenvironment. A hematopoietic stem cell is a cell from which all cells of the lymphoid and myeloid lineages develop, including blood cells and cells of the immune system.


go_id: GO:0097242
term: amyloid-beta clearance
ontology: BP
definition:
The process in which amyloid-beta is removed from extracellular brain regions by mechanisms involving cell surface receptors.


go_id: GO:0097243
term: flavonoid binding
ontology: MF
definition:
Binding to a flavonoid, a compound containing two or more aromatic rings, each bearing at least one aromatic hydroxyl and connected with a carbon bridge.


go_id: GO:0097246
term: catechin binding
ontology: MF
definition:
Binding to a catechin, a polyphenolic antioxidant plant metabolite with a flavonoid or flavan-3-ol structure.


go_id: GO:0097248
term: maintenance of protein location in cell cortex of cell tip
ontology: BP
definition:
A process in which a protein or protein complex is maintained in a specific location in the cell cortex of a cell tip, and is prevented from moving elsewhere. The cell cortex of a cell tip is the region directly beneath the plasma membrane at either end of the longest axis of a cylindrical or elongated cell.


go_id: GO:0097250
term: mitochondrial respirasome assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of respiratory enzyme complexes of the mitochondrial inner membrane (including, for example, complex II, complex III, complex IV) to form a large supercomplex.


go_id: GO:0097251
term: leukotriene B4 biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of leukotriene B4, a leukotriene composed of (6Z,8E,10E,14Z)-eicosatetraenoic acid having (5S)- and (12R)-hydroxy substituents.


go_id: GO:0097252
term: oligodendrocyte apoptotic process
ontology: BP
definition:
Any apoptotic process in an oligodendrocyte. Oligodendrocytes belong to a class of large neuroglial (macroglial) cells in the central nervous system, where they form the insulating myelin sheath of axons.


go_id: GO:0097253
term: beta-hydroxybutyrate transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of beta-hydroxybutyrate from one side of a membrane to the other. Beta-hydroxybutyrate is the conjugate base of (R)-3-hydroxybutyric acid.


go_id: GO:0097254
term: renal tubular secretion
ontology: BP
definition:
The elimination of substances from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine. Substances that are secreted include organic anions, ammonia, potassium and drugs.


go_id: GO:0097255
term: R2TP complex
ontology: CC
definition:
A highly conserved protein complex comprised of two ATP-dependent DNA helicases (Rvb1p and Rvb2p in yeast, Pontin52 and Reptin52 in humans), Pih1p in yeast or PIH1D1 in humans, and Tah1 in yeast or RPAP3 in humans. The complex associates with Hsp90 and is thought to have a role in assembly of large protein or protein/nucleic acid complexes. In this role it is involved in multiple processes such as box C/D snoRNP biogenesis, phosphatidylinositol-3 kinase-related protein kinase (PIKK) signaling, RNA polymerase II assembly, and others.


go_id: GO:0097258
term: 20-hydroxy-leukotriene B4 omega oxidase activity
ontology: MF
definition:
Catalysis of the reaction:  20-hydroxy-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-oxo-leukotriene B4 + H+ + 2 H2O + oxidized [NADPH-hemoprotein reductase].


go_id: GO:0097259
term: 20-aldehyde-leukotriene B4 20-monooxygenase activity
ontology: MF
definition:
Catalysis of the reaction: 20-oxo-leukotriene B4 + O2 + reduced [NADPH-hemoprotein reductase] = 20-carboxy-leukotriene B4 + 2 H+ + H2O + oxidized [NADPH-hemoprotein reductase].


go_id: GO:0097264
term: self proteolysis
ontology: BP
definition:
The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their own peptide bonds.


go_id: GO:0097266
term: phenylacetyl-CoA 1,2-epoxidase activity
ontology: MF
definition:
Catalysis of the reaction: phenylacetyl-CoA + H(+) + NADPH + O2 = 2-(1,2-epoxy-1,2-dihydrophenyl)acetyl-CoA + H2O + NADP(+).


go_id: GO:0097267
term: omega-hydroxylase P450 pathway
ontology: BP
definition:
The chemical reactions and pathways by which arachidonic acid is converted to other compounds initially by omega-hydroxylation.


go_id: GO:0097268
term: cytoophidium
ontology: CC
definition:
A subcellular filamentary structure where CTP synthase is compartmentalized in a range of organisms including bacteria, yeast, fruit fly, rat and human.


go_id: GO:0097269
term: all-trans-decaprenyl-diphosphate synthase activity
ontology: MF
definition:
Catalysis of the reaction: 2-trans,6-trans-farnesyl diphosphate + 7 isopentenyl diphosphate = 7 diphosphate + all-trans-decaprenyl diphosphate.


go_id: GO:0097271
term: protein localization to bud neck
ontology: BP
definition:
A process in which a protein is transported to, or maintained at, a location within a cellular bud neck.


go_id: GO:0097275
term: cellular ammonium homeostasis
ontology: BP
definition:
Any biological process involved in the maintenance of an internal steady state of ammonium at the level of the cell.


go_id: GO:0097276
term: cellular creatinine homeostasis
ontology: BP
definition:
Any biological process involved in the maintenance of an internal steady state of creatinine at the level of the cell.


go_id: GO:0097277
term: cellular urea homeostasis
ontology: BP
definition:
Any biological process involved in the maintenance of an internal steady state of urea at the level of the cell.


go_id: GO:0097279
term: histamine secretion mediated by IgE immunoglobulin
ontology: BP
definition:
Histamine release triggered by the binding of an antigen to an IgE immunoglobulin bound to the cell surface. An example is mast cell histamine degranulation as a result of exposure of mast cell-bound IgE to alder tree pollen.


go_id: GO:0097280
term: histamine secretion mediated by immunoglobulin
ontology: BP
definition:
Histamine release triggered by the binding of an antigen to an immunoglobulin bound to the cell surface.


go_id: GO:0097281
term: immune complex formation
ontology: BP
definition:
The process that gives rise to an immune complex. Immune complexes are clusters of antibodies bound to antigen, to which complement may also be fixed, and which may precipitate or remain in solution. Examples are the clumping of cells such as bacteria or red blood cells in the presence of an antibody, precipitation of a toxin after an antibody binds to it, and clumping of viral particles as a result of antibody binding to the virus.


go_id: GO:0097282
term: immunoglobulin-mediated neutralization
ontology: BP
definition:
The inhibition of an antigen's biological effects by antibody binding to it. An example is neutralization of diphtheria toxin by preventing its entry into human cells via the binding of antibody specific for diphtheria toxin.


go_id: GO:0097283
term: keratinocyte apoptotic process
ontology: BP
definition:
Any apoptotic process in a keratinocyte. A keratinocyte is an epidermal cell which synthesizes keratin and undergoes a characteristic change as it moves upward from the basal layers of the epidermis to the cornified (horny) layer of the skin.


go_id: GO:0097287
term: 7-cyano-7-deazaguanine metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile or preQo.


go_id: GO:0097288
term: 7-cyano-7-deazaguanine biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of the Q nucleoside precursor 7-cyano-7-deazaguanine, also known as 2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile or preQo.


go_id: GO:0097289
term: alpha-ribazole metabolic process
ontology: BP
definition:
The chemical reactions and pathways involving alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12).


go_id: GO:0097290
term: alpha-ribazole biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of alpha-ribazole, the benzimidazole nucleoside in adenosyl cobalamin (vitamin B12).


go_id: GO:0097291
term: renal phosphate ion absorption
ontology: BP
definition:
A renal system process in which phosphate ions are taken up from the collecting ducts and proximal and distal loops of the nephron. In non-mammalian species, absorption may occur in related structures.


go_id: GO:0097294
term: 'de novo' XMP biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of XMP, xanthosine monophosphate, from simpler precursors.


go_id: GO:0097295
term: morphine biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of morphine, 17-methyl-7,8-didehydro-4,5alpha-epoxymorphinan-3,6alpha-diol. Morphine is a highly potent opiate analgesic psychoactive drug obtained form the opium poppy, Papaver somniferum.


go_id: GO:0097296
term: activation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway
ontology: BP
definition:
Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the apoptotic signaling pathway.


go_id: GO:0097297
term: activation of cysteine-type endopeptidase activity involved in execution phase of apoptosis
ontology: BP
definition:
Any process that initiates the activity of an inactive cysteine-type endopeptidase involved in the execution phase of apoptosis.


go_id: GO:0097300
term: programmed necrotic cell death
ontology: BP
definition:
A necrotic cell death process that results from the activation of endogenous cellular processes, such as signaling involving death domain receptors or Toll-like receptors.


go_id: GO:0097302
term: lipoprotein biosynthetic process via diacylglyceryl transfer
ontology: BP
definition:
The chemical reactions and pathways by which diacylglyceryl transfer leads to formation of a water-soluble protein-lipid complex.


go_id: GO:0097303
term: lipoprotein biosynthetic process via N-acyl transfer
ontology: BP
definition:
The chemical reactions and pathways by which N-acyl transfer leads to formation of a water-soluble protein-lipid complex.


go_id: GO:0097304
term: lipoprotein biosynthetic process via signal peptide cleavage
ontology: BP
definition:
The chemical reactions and pathways by which signal peptide cleavage leads to formation of a water-soluble protein-lipid complex.


go_id: GO:0097305
term: response to alcohol
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus.


go_id: GO:0097306
term: cellular response to alcohol
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an alcohol stimulus.


go_id: GO:0097307
term: response to farnesol
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus.


go_id: GO:0097308
term: cellular response to farnesol
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a farnesol stimulus.


go_id: GO:0097311
term: bacterial biofilm matrix
ontology: CC
definition:
A structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria.


go_id: GO:0097313
term: bacterial biofilm matrix surface
ontology: CC
definition:
The external part of the biofilm matrix, a structure lying external to bacterial cells. A biofilm is an aggregate of surface-associated bacteria, and the biofilm matrix is the envelope of polymeric substances that surrounds the bacteria.


go_id: GO:0097314
term: apoptosome assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of the apoptosome, a multisubunit protein complex involved in the signaling phase of the apoptotic process.


go_id: GO:0097315
term: response to N-acetyl-D-glucosamine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus.


go_id: GO:0097316
term: cellular response to N-acetyl-D-glucosamine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an N-acetyl-D-glucosamine stimulus.


go_id: GO:0097317
term: invasive growth in response to biotic stimulus
ontology: BP
definition:
The growth of colonies in filamentous chains of cells as a result of a biotic stimulus. An example of this is Candida albicans forming invasive filaments in agar medium in response to a serum stimulus.


go_id: GO:0097318
term: invasive growth in response to abiotic stimulus
ontology: BP
definition:
The growth of colonies in filamentous chains of cells as a result of a abiotic stimulus. An example of this process is found in Candida albicans.


go_id: GO:0097321
term: cell growth mode switching, filamentous to budding
ontology: BP
definition:
The process in which a cell switches from growing as a filament (elongated cells attached end-to-end) to growing as a round budding cell. An example of this is observed in Candida albicans.


go_id: GO:0097324
term: melanocyte migration
ontology: BP
definition:
The orderly movement of melanocytes from one site to another, often during the development of a multicellular organism. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance.


go_id: GO:0097325
term: melanocyte proliferation
ontology: BP
definition:
The multiplication or reproduction of melanocytes, resulting in the expansion of a cell population. A melanocyte is a pigment cell derived from the neural crest. It contains melanin-filled pigment granules, which give a brown to black appearance.


go_id: GO:0097327
term: response to antineoplastic agent
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antineoplastic agent stimulus. An antineoplastic agent is a substance that inhibits or prevents the proliferation of neoplasms.


go_id: GO:0097328
term: response to carboplatin
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a carboplatin stimulus.


go_id: GO:0097329
term: response to antimetabolite
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antimetabolite stimulus. An antimetabolite is a substance which is structurally similar to a metabolite but which competes with it or replaces it, and so prevents or reduces its normal utilization.


go_id: GO:0097330
term: response to 5-fluoro-2'-deoxyuridine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a 5-fluoro-2'-deoxyuridine stimulus. 5-fluoro-2'-deoxyuridine is a pyrimidine 2'-deoxyribonucleoside compound having 5-fluorouracil as the nucleobase; it is used to treat hepatic metastases of gastrointestinal adenocarcinomas and for palliation in malignant neoplasms of the liver and gastrointestinal tract.


go_id: GO:0097331
term: response to cytarabine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cytarabine stimulus.


go_id: GO:0097332
term: response to antipsychotic drug
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antipsychotic drug stimulus. Antipsychotic drugs are agents that control agitated psychotic behaviour, alleviate acute psychotic states, reduce psychotic symptoms, and exert a quieting effect.


go_id: GO:0097333
term: response to olanzapine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an olanzapine stimulus.


go_id: GO:0097334
term: response to perphenazine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a perphenazine stimulus. Perphenazine is a phenothiazine derivative having a chloro substituent at the 2-position and a 3-[4-(2-hydroxyethyl)piperazin-1-yl]propyl group at the N-10 position.


go_id: GO:0097335
term: response to quetiapine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a quetiapine stimulus.


go_id: GO:0097336
term: response to risperidone
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a risperidone stimulus.


go_id: GO:0097337
term: response to ziprasidone
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a ziprasidone stimulus. Ziprasidone is a piperazine compound having 1,2-benzothiazol-3-yl- and 2-(6-chloro-1,3-dihydro-2-oxindol-5-yl)ethyl substituents attached to the nitrogen atoms.


go_id: GO:0097338
term: response to clozapine
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a clozapine stimulus.


go_id: GO:0097339
term: glycolate transmembrane transport
ontology: BP
definition:
The process in which glycolate is transported across a membrane. Glycolate is the anion of hydroxyethanoic acid (glycolic acid).


go_id: GO:0097342
term: ripoptosome
ontology: CC
definition:
A protein complex whose core components are the receptor-interacting serine/threonine-protein kinases RIPK1 and RIPK3 (also called RIP1 and RIP3). Formation of the ripoptosome can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more.


go_id: GO:0097343
term: ripoptosome assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a ripoptosome, a protein complex whose formation can induce an extrinsic apoptotic signaling pathway or a necroptotic signaling pathway. The composition of this protein complex may depend on several factors including nature of the signal, cell type and more.


go_id: GO:0097344
term: Rix1 complex
ontology: CC
definition:
A protein complex that comprises Rix1p, Ipi1p and Ipi3p, and is required for processing of ITS2 sequences from 35S pre-rRNA. The Rix1 complex has been identified in budding yeast and fission yeast, and members of this complex are conserved in higher eukaryotes.


go_id: GO:0097345
term: mitochondrial outer membrane permeabilization
ontology: BP
definition:
The process by which the mitochondrial outer membrane becomes permeable to the passing of proteins and other molecules from the intermembrane space to the cytosol as part of the apoptotic signaling pathway.


go_id: GO:0097346
term: INO80-type complex
ontology: CC
definition:
A chromatin remodeling protein complex initially purified from S. cerevisiae and containing more than 10 subunits, including the SWR1-related complexes. INO80 (inositol requiring 80)-type complexes have diverse functions, including promoting transcriptional activation and DNA repair.


go_id: GO:0097347
term: TAM protein secretion complex
ontology: CC
definition:
A heterooligomeric protein complex that spans the bacterial periplasm and enables the secretion of adhesin proteins in Gram-negative bacteria. In Citrobacter rodentium, Salmonella enterica and Escherichia coli, the TAM complex consists of an Omp85-family protein, TamA, in the outer membrane and TamB in the inner membrane.


go_id: GO:0097351
term: toxin sequestering activity
ontology: MF
definition:
Binding to a toxin to prevent it from interacting with other partners or to inhibit its localization to the area of the cell or complex where it is active.


go_id: GO:0097352
term: autophagosome maturation
ontology: BP
definition:
Removal of PI3P and Atg8/LC3 after the closure of the phagophore and before the fusion with the endosome/lysosome (e.g. mammals and insects) or vacuole (yeast), and that very likely destabilizes other Atg proteins and thus enables their efficient dissociation and recycling.


go_id: GO:0097353
term: centrolateral pattern formation
ontology: BP
definition:
The regionalization process in which the areas along the centrolateral axis are established that will lead to differences in cell differentiation, or in which cells interpret a specific environment.


go_id: GO:0097354
term: prenylation
ontology: BP
definition:
The covalent attachment of a prenyl group to a molecule; geranyl, farnesyl, or geranylgeranyl groups may be added.


go_id: GO:0097355
term: protein localization to heterochromatin
ontology: BP
definition:
Any process in which a protein is transported to, or maintained at, a part of a chromosome that is organized into heterochromatin.


go_id: GO:0097356
term: perinucleolar compartment
ontology: CC
definition:
The perinucleolar compartment (PNC) is a subnuclear structure associated with, but structurally distinct from, the nucleolus. The PNC contains large amounts of the heterogeneous nuclear ribonucleoprotein complex (hnRNP) called hnRNP 1 (PTB). Many RNA binding proteins as well as RNA polymerase III transcripts are highly enriched in this compartment. PTB and pol III transcripts are required for the integrity of the PNC.


go_id: GO:0097358
term: D-leucyl-tRNA(Leu) deacylase activity
ontology: MF
definition:
Catalysis of the reaction: D-leucyl-tRNA(Leu) = D-leucine + tRNA(Leu). Hydrolysis of the removal of D-leucine from residues in charged tRNA(Leu).


go_id: GO:0097360
term: chorionic trophoblast cell proliferation
ontology: BP
definition:
The multiplication or reproduction of chorionic trophoblast cells, resulting in the expansion of their population.


go_id: GO:0097361
term: CIA complex
ontology: CC
definition:
The cytosolic iron-sulfur protein assembly (CIA) complex mediates the incorporation of iron-sulfur clusters into apoproteins involved in DNA metabolism and genomic integrity.


go_id: GO:0097362
term: MCM8-MCM9 complex
ontology: CC
definition:
A hexameric protein complex composed of MCM8 and MCM9 and involved in homologous recombination repair following DNA interstrand cross-links.


go_id: GO:0097363
term: protein O-GlcNAc transferase activity
ontology: MF
definition:
Catalysis of the reaction: UDP-N-acetyl-D-glucosamine + [protein]-L-serine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-serine, or UDP-N-acetyl-D-glucosamine + [protein]-L-threonine = UDP + [protein]-3-O-(N-acetyl-D-glucosaminyl)-L-threonine.


go_id: GO:0097364
ontology: MF
term:
stretch-activated, cation-selective, calcium channel activity involved in regulation of action potential

definition:
Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential.


go_id: GO:0097365
ontology: MF
term:
stretch-activated, cation-selective, calcium channel activity involved in regulation of cardiac muscle cell action potential

definition:
Enables the transmembrane transfer of a calcium ion by a channel that opens in response to a mechanical stress in the form of stretching, and contributing to the regulation of action potential in a cardiac muscle cell.


go_id: GO:0097366
term: response to bronchodilator
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a bronchodilator stimulus. A bronchodilator is a chemical that causes an increase in the expansion of a bronchus or bronchial tubes.


go_id: GO:0097368
term: establishment of Sertoli cell barrier
ontology: BP
definition:
Establishment of a structure near the basement membrane in adjacent Sertoli cells of the seminiferous epithelium for maintaining spermatogenesis. The structure consists of tight junctions, basal ectoplasmic specializations, and desmosome-like junctions.


go_id: GO:0097370
term: protein O-GlcNAcylation via threonine
ontology: BP
definition:
The glycosylation of a protein by addition of N-acetylglucosamine via the O3 atom of peptidyl-threonine, forming O3-N-acetylglucosamine-L-threonine.


go_id: GO:0097372
term: NAD-dependent histone deacetylase activity (H3-K18 specific)
ontology: MF
definition:
Catalysis of the reaction: histone H3 N6-acetyl-L-lysine (position 18) + H2O = histone H3 L-lysine (position 18) + acetate. This reaction requires the presence of NAD, and represents the removal of an acetyl group from lysine at position 18 of the histone H3 protein.


go_id: GO:0097373
term: MCM core complex
ontology: CC
definition:
A protein complex that contains Mcm4, Mcm6, and Mcm7 proteins, and possesses DNA helicase activity. In the heterohexameric MCM complex, the Mcm4/6/7 proteins form a stable core, and Mcm2, Mcm3, and Mcm5 are more peripherally associated.


go_id: GO:0097374
term: sensory neuron axon guidance
ontology: BP
definition:
The process in which the migration of an axon growth cone of a sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A sensory neuron is an afferent neuron conveying sensory impulses.


go_id: GO:0097375
term: spinal sensory neuron axon guidance
ontology: BP
definition:
The process in which the migration of an axon growth cone of a spinal sensory neuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal sensory neuron is a sensory neuron that project to the spinal cord.


go_id: GO:0097376
term: interneuron axon guidance
ontology: BP
definition:
The process in which the migration of an axon growth cone of an interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. An interneuron is any neuron which is not motor or sensory. Interneurons may also refer to neurons whose axons remain within a particular brain region, as contrasted with projection neurons which have axons projecting to other brain regions.


go_id: GO:0097377
term: spinal cord interneuron axon guidance
ontology: BP
definition:
The process in which the migration of an axon growth cone of a spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A spinal cord interneuron is a CNS interneuron located in the spinal cord.


go_id: GO:0097378
term: dorsal spinal cord interneuron axon guidance
ontology: BP
definition:
The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in response to a combination of attractive and repulsive cues. A dorsal spinal cord interneuron is an interneuron located in the dorsal part of the spinal cord.


go_id: GO:0097379
term: dorsal spinal cord interneuron posterior axon guidance
ontology: BP
definition:
The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the posterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.


go_id: GO:0097380
term: dorsal spinal cord interneuron anterior axon guidance
ontology: BP
definition:
The process in which the migration of an axon growth cone of a dorsal spinal cord interneuron is directed to a specific target site in the anterior direction along the anterior-posterior body axis in response to a combination of attractive and repulsive cues. The anterior-posterior axis is defined by a line that runs from the head or mouth of an organism to the tail or opposite end of the organism.


go_id: GO:0097381
term: photoreceptor disc membrane
ontology: CC
definition:
Stack of disc membranes located inside a photoreceptor outer segment, and containing densely packed molecules of photoreceptor proteins that traverse the lipid bilayer. Disc membranes arise as evaginations of the ciliary membrane during the development of the outer segment and may or may not remain contiguous with the ciliary membrane.


go_id: GO:0097384
term: cellular lipid biosynthetic process
ontology: BP
definition:
The chemical reactions and pathways resulting in the formation of lipids, as carried out by individual cells.


go_id: GO:0097385
term: programmed necrotic cell death in response to starvation
ontology: BP
definition:
A programmed necrotic cell death occurring as a result of a starvation stimulus (deprivation of nourishment).


go_id: GO:0097387
term: capitate projection
ontology: CC
definition:
Simple or compound process of epithelial glial cells with a spherical head that inserts into photoreceptor axons. Capitate projections have only been observed in Brachycera (flies).


go_id: GO:0097388
term: chemokine (C-C motif) ligand 19 production
ontology: BP
definition:
The appearance of chemokine (C-C motif) ligand 19 (CCL19) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0097389
term: chemokine (C-C motif) ligand 21 production
ontology: BP
definition:
The appearance of chemokine (C-C motif) ligand 21 (CCL21) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0097390
term: chemokine (C-X-C motif) ligand 12 production
ontology: BP
definition:
The appearance of chemokine (C-X-C motif) ligand 12 (CXCL12) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0097391
term: chemokine (C-X-C motif) ligand 13 production
ontology: BP
definition:
The appearance of chemokine (C-X-C motif) ligand 13 (CXCL13) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0097392
term: chemokine (C-X-C motif) ligand 16 production
ontology: BP
definition:
The appearance of chemokine (C-X-C motif) ligand 16 (CXCL16) due to biosynthesis or secretion following a cellular stimulus, resulting in an increase in its intracellular or extracellular levels.


go_id: GO:0097393
term: telomeric repeat-containing RNA transcription
ontology: BP
definition:
The synthesis of telomeric repeat-containing RNA from a DNA template. A telomere is a complex of DNA and proteins that seals the end of a chromosome.


go_id: GO:0097394
term: telomeric repeat-containing RNA transcription by RNA polymerase II
ontology: BP
definition:
The synthesis of telomeric repeat-containing RNA from a DNA template by RNA polymerase II (Pol II), originating at a Pol II promoter.


go_id: GO:0097395
term: response to interleukin-32
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus.


go_id: GO:0097396
term: response to interleukin-17
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus.


go_id: GO:0097397
term: cellular response to interleukin-32
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-32 stimulus.


go_id: GO:0097398
term: cellular response to interleukin-17
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an interleukin-17 stimulus.


go_id: GO:0097399
term: interleukin-32-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-32 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0097400
term: interleukin-17-mediated signaling pathway
ontology: BP
definition:
The series of molecular signals initiated by interleukin-17 binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process, e.g. transcription.


go_id: GO:0097401
term: synaptic vesicle lumen acidification
ontology: BP
definition:
The acidification of the synaptic vesicle lumen via transport of protons into the vesicle. The resulting electrochemical gradient powers neurotransmitter loading.


go_id: GO:0097402
term: neuroblast migration
ontology: BP
definition:
The orderly movement of a neuroblast from one site to another, often during the development of a multicellular organism or multicellular structure. A neuroblast is any cell that will divide and give rise to a neuron.


go_id: GO:0097403
term: cellular response to raffinose
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a raffinose stimulus.


go_id: GO:0097407
term: Bunina body
ontology: CC
definition:
Small granular inclusions (about 1-3 microns in diameter) found in the anterior horn cells, and appearing either singly or in a group. Sometimes they are arranged in small beaded chains. Bunina bodies express cystatin C and consist of electron-dense amorphous material that contains tubules or vesicular structures. The amorphous material frequently includes a cytoplasmic island containing neurofilaments and other micro-organelles.


go_id: GO:0097408
term: fibrillary inclusion
ontology: CC
definition:
Cellular inclusion consisting of circular areas filled with fine slender filaments about 10 nanometers in diameter, delimited by a wall of varying complexity (either a single continuous membrane or a tubular network consisting of a fine filamentous material giving the wall a honeycomb appearance). Fibrillary inclusions are found in the cytoplasm of giant cells of Dieters in the lateral vestibular nucleus of the rat; similar structures have been described in the ventral cochlear nucleus, spinal cord, and substantia nigra.


go_id: GO:0097409
term: glial cytoplasmic inclusion
ontology: CC
definition:
Non-membrane-bound cytoplasmic inclusions composed of 10-40 nm granule-coated fibrils. These inclusions have an abnormal accumulation of alpha-synuclein protein and are found in association with multiple system atrophy.


go_id: GO:0097410
term: hippocampal interneuron differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a hippocampal interneuron.


go_id: GO:0097411
term: hypoxia-inducible factor-1alpha signaling pathway
ontology: BP
definition:
The series of molecular signals mediated by hypoxia-inducible factor (HIF1) in response to lowered oxygen levels (hypoxia). Under hypoxic conditions, the oxygen-sensitive alpha-subunit of hypoxia-inducible factor (HIF)-1 dimerizes with a HIF1-beta subunit (also called ARNT or aryl-hydrocarbon-receptor nuclear translocator), translocates to the nucleus and activates transcription of genes whose products participate in responding to hypoxia.


go_id: GO:0097413
term: Lewy body
ontology: CC
definition:
Cytoplasmic, spherical inclusion commonly found in damaged neurons, and composed of abnormally phosphorylated, neurofilament proteins aggregated with ubiquitin and alpha-synuclein.


go_id: GO:0097414
term: classical Lewy body
ontology: CC
definition:
Cytoplasmic inclusion, 5 to 15 micrometers in diameter, with a dense core surrounded by a halo of 10 to 20 nm wide radially oriented alpha-synuclein fibrils.


go_id: GO:0097416
term: Lewy body-like hyaline inclusion
ontology: CC
definition:
Cytoplasmic inclusion found in neurons. It consists of filaments and granular materials, exhibits a dense core with a rough peripheral halo and lacks a limiting membrane. The filaments of these inclusions are composed of approximately 15-25 nm granule-coated fibrils in association with normal 10-nm neurofilaments.


go_id: GO:0097417
term: nematosome
ontology: CC
definition:
Cytoplasmic, ball-like inclusion resembling a nucleolus and consisting of a convoluted network of electron-opaque strands embedded in a less dense matrix. It measures approximately 0.9 microns and lacks a limiting membrane. Its strands (diameter = 400-600 A) appear to be made of an entanglement of tightly packed filaments and particles approximately 25-50 A thick. Cytochemical studies suggest the presence of nonhistone proteins and some RNA. Usually only one such structure is present in a cell, and it appears to occur in most ganglion cells. Although they can be seen anywhere in the cell body, nematosomes are typically located in the perinuclear cytoplasm, where they are often associated with smooth-surfaced and coated vesicles.


go_id: GO:0097418
term: neurofibrillary tangle
ontology: CC
definition:
Intracellular mass of paired, helically wound protein filaments (also called PHF) lying in the cytoplasm of neuronal cell bodies and neuritic cell processes. Neurofibrillary tangles contain an abnormally phosphorylated form of a microtubule-associated protein, tau. The shape of these inclusions may resemble a flame or a star.


go_id: GO:0097419
term: Pick body
ontology: CC
definition:
Cellular inclusion composed of numerous tau fibrils arranged in a disorderly array. Tau protein is a major component, though Pick bodies also contain ubiquitin, alpha-synuclein, and apolipoprotein E.


go_id: GO:0097420
term: skein-like inclusion
ontology: CC
definition:
Intracytoplasmic filamentous structure frequently encountered in preparations immunostained for ubiquitin.


go_id: GO:0097423
term: mitochondrion-associated adherens complex
ontology: CC
definition:
An organelle arrangement comprised of the following elements: a mitochondrion positioned near the presynaptic membrane; an electron-dense mitochondrial plaque adjacent to the outer mitochondrial membrane that faces the presynaptic membrane; filament-like elements appearing to link the mitochondrial plaque to a cell-cell junction region (sometimes termed punctum adherens); tubular or vesicular-appearing membrane (also called vesicular chain) interposed among the filaments. Mitochondrion-associated adherens complexes were initially described in the dorsal horn of the spinal cord. They are found in calyces and other large terminals of the auditory brainstem, and in a variety of mammalian species including humans.


go_id: GO:0097424
term: nucleolus-associated heterochromatin
ontology: CC
definition:
Dense particles of heterochromatin, consisting of a loosely twisted strand about 600 Angstrom thick, found associated with the nucleolus.


go_id: GO:0097426
term: glial filament
ontology: CC
definition:
An intermediate filament composed of glial fibrillary acidic protein (GFAP) and found in astrocytes.


go_id: GO:0097428
term: protein maturation by iron-sulfur cluster transfer
ontology: BP
definition:
The transfer of an assembled iron-sulfur cluster from a scaffold protein to an acceptor protein that contributes to the attainment of the full functional capacity of a protein.


go_id: GO:0097429
term: amino acid ligation activity by nonribosomal peptide synthase
ontology: MF
definition:
Catalysis of the ligation of an amino acid to another amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate, carried out by a nonribosomal peptide synthase.


go_id: GO:0097430
term: copper ion import across prospore membrane
ontology: BP
definition:
The directed movement of copper ions from outside of a cell, across an ascospore-type prospore membrane and into the cytosol.


go_id: GO:0097431
term: mitotic spindle pole
ontology: CC
definition:
Either of the ends of a mitotic spindle, a spindle that forms as part of mitosis, where spindle microtubules are organized; usually contains a microtubule organizing center and accessory molecules, spindle microtubules and astral microtubules.


go_id: GO:0097432
term: hippocampal pyramidal neuron differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a hippocampal pyramidal neuron, a pyramidal cell of the hippocampus.


go_id: GO:0097434
term: succinate:proton symporter activity
ontology: MF
definition:
Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: succinate(out) + H+(out) = succinate(in) + H+(in).


go_id: GO:0097435
term: supramolecular fiber organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a supramolecular fiber, a polymer consisting of an indefinite number of protein or protein complex subunits that have polymerised to form a fiber-shaped structure.


go_id: GO:0097436
term: entry into dormancy
ontology: BP
definition:
The dormancy process that results in entry into dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated.


go_id: GO:0097437
term: maintenance of dormancy
ontology: BP
definition:
The dormancy process that results in an organism remaining in dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated.


go_id: GO:0097438
term: exit from dormancy
ontology: BP
definition:
The dormancy process that results in exit from dormancy. Dormancy (sometimes called a dormant state) is a suspension of most physiological activity and growth that can be reactivated.


go_id: GO:0097439
term: acquisition of desiccation tolerance
ontology: BP
definition:
The process in which tolerance to severe drying is acquired, before entering into a dry, either dormant or quiescent state.


go_id: GO:0097440
term: apical dendrite
ontology: CC
definition:
A dendrite that emerges near the apical pole of a neuron. In bipolar neurons, apical dendrites are located on the opposite side of the soma from the axon.


go_id: GO:0097441
term: basal dendrite
ontology: CC
definition:
A dendrite that emerges near the basal pole of a neuron. In bipolar neurons, basal dendrites are either on the same side of the soma as the axon, or project toward the axon.


go_id: GO:0097443
term: sorting endosome
ontology: CC
definition:
A multivesicular body surrounded by and connected with multiple tubular compartments with associated vesicles.


go_id: GO:0097444
term: spine apparatus
ontology: CC
definition:
A specialization of the endomembrane system found in some classes of dendritic spines consisting of two or more closely apposed lamellae with interspersed electron dense material.  The endomembrane component is continuous with the smooth endoplasmic reticulum.


go_id: GO:0097445
term: presynaptic active zone dense projection
ontology: CC
definition:
Electron dense projection extending from the cytomatrix into the cytoplasm on which synaptic vesicles are tethered.


go_id: GO:0097446
term: protein localization to eisosome filament
ontology: BP
definition:
A process in which a protein is transported to, and/or maintained in, a specific location in a eisosome filament (also called linear eisosome), a filamentous cortical structure formed, in S. pombe, by the eisosome component Pil1.


go_id: GO:0097447
term: dendritic tree
ontology: CC
definition:
The entire complement of dendrites for a neuron, consisting of each primary dendrite and all its branches.


go_id: GO:0097448
term: spine mat
ontology: CC
definition:
A configuration of neuron spines found on ciliary ganglion neurons in the embryonic and adult brain consisting of patches of closely spaced spines lying flat against the soma.


go_id: GO:0097451
term: glial limiting end-foot
ontology: CC
definition:
Terminal process of astrocyte that extends to the surface of the central nervous system. Together, glial limiting end-feet form the glial limiting membrane or glia limitans.


go_id: GO:0097452
term: GAIT complex
ontology: CC
definition:
A protein complex which mediates interferon-gamma-induced transcript-selective translation inhibition in inflammation processes. The complex binds to stem loop-containing GAIT elements in the 3'-UTR of diverse inflammatory mRNAs and suppresses their translation by blocking the recruitment of the 43S ribosomal complex to m7G cap-bound eIF4G. In humans it includes RPL13A, EPRS, SYNCRIP and GAPDH; mouse complexes lack SYNCRIP.


go_id: GO:0097453
term: mesaxon
ontology: CC
definition:
Portion of the ensheathing process (either myelin or non-myelin) where the enveloping lips of the ensheathing cell come together so that their apposed plasma membranes run parallel to each other, separated by a cleft 12 nm wide.


go_id: GO:0097455
term: spiny bracelet of Nageotte
ontology: CC
definition:
Paranodal terminations of Schwann cells that do not directly contact the paranodal axon membrane. Usually found in thicker myelin.


go_id: GO:0097456
term: terminal loop
ontology: CC
definition:
Portion of myelin-forming Schwann cell consisting of terminal cytoplasmic extensions adhered to the axon at the beginning and end of the myelin sheath.


go_id: GO:0097457
term: hippocampal mossy fiber
ontology: CC
definition:
Axon of dentate gyrus granule cell projecting to hippocampal area CA3, characterized by expansions (mossy fiber expansions) giving the fibers a mossy appearance. These unmyelinated axons were first described by Ramon y Cajal.


go_id: GO:0097462
term: Lewy neurite
ontology: CC
definition:
Elongated neuronal process, often with side branches and more than one branching point, described in brains of patients with Parkinson's disease. Lewy neurites stain positively for ubiquitin in brainstem and forebrain regions affected in Parkinson's disease.


go_id: GO:0097464
term: thorny excrescence
ontology: CC
definition:
Large complex spine protruding from a dendrite. Each excrescence is formed by a cluster of spine heads.


go_id: GO:0097466
term: ubiquitin-dependent glycoprotein ERAD pathway
ontology: BP
definition:
An ERAD pathway whereby endoplasmic reticulum (ER)-resident glycoproteins are targeted for degradation. Includes differential processing of the glycoprotein sugar chains, retrotranslocation to the cytosol and degradation by the ubiquitin-proteasome pathway. A glycoprotein is a compound in which a carbohydrate component is covalently bound to a protein component.


go_id: GO:0097467
term: type III terminal bouton
ontology: CC
definition:
Terminal inflated portion of the axon of a non-glutamatergic neuron, containing the specialized apparatus necessary to release neurotransmitters at a regulatory synapse. The axon terminus is considered to be the whole region of thickening and the terminal bouton is a specialized region of it. Type III terminal boutons are larger than type II ones.


go_id: GO:0097468
term: programmed cell death in response to reactive oxygen species
ontology: BP
definition:
Cell death resulting from activation of endogenous cellular processes and occurring as a result of a reactive oxygen species stimulus. Reactive oxygen species include singlet oxygen, superoxide, and oxygen free radicals.


go_id: GO:0097470
term: ribbon synapse
ontology: CC
definition:
Type of synapse characterized by an electron-dense ribbon, lamella (bar) or spherical body in the presynaptic process cytoplasm.


go_id: GO:0097471
term: mossy fiber rosette
ontology: CC
definition:
A synapse of a mossy fiber onto the dendrite of a granule cell; each mossy fiber can have up to 50 rosettes.


go_id: GO:0097472
term: cyclin-dependent protein kinase activity
ontology: MF
definition:
Cyclin-dependent catalysis of the phosphorylation of an amino acid residue in a protein, usually according to the reaction: a protein + ATP = a phosphoprotein + ADP.


go_id: GO:0097473
term: retinal rod cell apoptotic process
ontology: BP
definition:
Any apoptotic process in a retinal rod cell, one of the two photoreceptor cell types of the vertebrate retina.


go_id: GO:0097474
term: retinal cone cell apoptotic process
ontology: BP
definition:
Any apoptotic process in a retinal cone cell, one of the two photoreceptor cell types of the vertebrate retina.


go_id: GO:0097475
term: motor neuron migration
ontology: BP
definition:
The orderly movement of a motor neuron from one site to another. A motor neuron is an efferent neuron that passes from the central nervous system or a ganglion toward or to a muscle and conducts an impulse that causes movement.


go_id: GO:0097476
term: spinal cord motor neuron migration
ontology: BP
definition:
The orderly movement of a spinal cord motor neuron from one site to another. A spinal cord motor neuron is a motor neuron that passes from the spinal cord toward or to a muscle and conducts an impulse that causes movement.


go_id: GO:0097477
term: lateral motor column neuron migration
ontology: BP
definition:
The orderly movement of a lateral motor column neuron from one site to another. A lateral motor column neuron is a motor neuron that is generated only on limb levels and send axons into the limb mesenchyme.


go_id: GO:0097479
term: synaptic vesicle localization
ontology: BP
definition:
Any process in which a synaptic vesicle or vesicles are transported to, and/or maintained in, a specific location.


go_id: GO:0097485
term: neuron projection guidance
ontology: BP
definition:
The process in which the migration of a neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.


go_id: GO:0097490
term: sympathetic neuron projection extension
ontology: BP
definition:
Long distance growth of a single sympathetic neuron projection involved in cellular development. A neuron projection is a prolongation or process extending from a nerve cell, e.g. an axon or dendrite.


go_id: GO:0097491
term: sympathetic neuron projection guidance
ontology: BP
definition:
The process in which the migration of a sympathetic neuron projection is directed to a specific target site in response to a combination of attractive and repulsive cues.


go_id: GO:0097492
term: sympathetic neuron axon guidance
ontology: BP
definition:
The chemotaxis process that directs the migration of a sympathetic neuron axon growth cone to a specific target site in response to a combination of attractive and repulsive cues.


go_id: GO:0097493
term: structural molecule activity conferring elasticity
ontology: MF
definition:
The action of a molecule that contributes to the structural integrity of a complex or assembly within or outside a cell, providing elasticity and recoiling.


go_id: GO:0097495
term: H-NS-Hha complex
ontology: CC
definition:
A trimeric protein complex made up of an H-NS homodimer and an Hha monomer. In Enterobacteriaceae, this complex negatively regulates transcription of a range of genes.


go_id: GO:0097496
term: blood vessel lumen ensheathment
ontology: BP
definition:
A blood vessel lumenization process that occurs by blood vessel endothelial cells delaminating and aligning along the inner surface of an existing luminal space, extending the open ended lumen, and joining to other blood vessels to form a complete blood vessel.


go_id: GO:0097497
term: blood vessel endothelial cell delamination
ontology: BP
definition:
The process of negative regulation of cell adhesion that results in blood vessel endothelial cells splitting off from an existing endothelial sheet.


go_id: GO:0097499
term: protein localization to non-motile cilium
ontology: BP
definition:
A process in which a protein is transported to, or maintained in, a location within a non-motile cilium.


go_id: GO:0097500
term: receptor localization to non-motile cilium
ontology: BP
definition:
A process in which a receptor is transported to, or maintained in, a location within a non-motile cilium.


go_id: GO:0097501
term: stress response to metal ion
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by a metal ion stimulus.


go_id: GO:0097504
term: Gemini of coiled bodies
ontology: CC
definition:
Nuclear bodies frequently found near or associated with Cajal bodies (also called coiled bodies or CBs). Gemini of coiled bodies, or 'gems', are similar in size and shape to CBs, and often indistinguishable under the microscope. Unlike CBs, gems do not contain small nuclear ribonucleoproteins (snRNPs); they contain a protein called survivor of motor neurons (SMN) whose function relates to snRNP biogenesis. Gems are believed to assist CBs in snRNP biogenesis, and to play a role in the etiology of spinal muscular atrophy (SMA).


go_id: GO:0097505
term: Rad6-Rad18 complex
ontology: CC
definition:
A ubiquitin ligase complex found to be involved in post-replicative bypass of UV-damaged DNA and UV mutagenesis. In S. cerevisiae, the complex contains the ubiquitin conjugating enzyme Rad6 and Rad18, a protein containing a RING finger motif and a nucleotide binding motif. The yeast Rad6-Rad18 heterodimer has ubiquitin conjugating activity, binds single-stranded DNA, and possesses single-stranded DNA-dependent ATPase activity.


go_id: GO:0097509
term: oxanine DNA N-glycosylase activity
ontology: MF
definition:
DNA N-glycosylase activity acting on deaminated guanine where the resulting base (oxanine) is generated by NO- or HNO2-induced nitrosative deamination.


go_id: GO:0097511
term: dendritic cell dendrite
ontology: CC
definition:
A branched cellular projection (or cytoplasmic extension) that is extended from the surface of a dendritic immune cell, and which enables the cell to sample luminal pathogens and increase the surface area for antigen presentation to T cells.


go_id: GO:0097514
term: sexual spore wall
ontology: CC
definition:
A specialized envelope lying outside the cell membrane of a spore derived from a product of meiosis.


go_id: GO:0097515
term: asexual spore wall
ontology: CC
definition:
A specialized envelope lying outside the cell membrane of a spore derived from an asexual process. Examples of this process are found in bacterial and fungal species.


go_id: GO:0097517
term: contractile actin filament bundle
ontology: CC
definition:
An actin filament bundle in which the filaments are loosely packed (approximately 30-60 nm apart) and arranged with opposing polarities; the loose packing allows myosin (usually myosin-II) to enter the bundle.


go_id: GO:0097518
term: parallel actin filament bundle
ontology: CC
definition:
An actin filament bundle in which the filaments are tightly packed (approximately 10-20 nm apart) and oriented with the same polarity.


go_id: GO:0097519
term: DNA recombinase complex
ontology: CC
definition:
A protein-DNA complex consisting of a higher-order oligomer of strand exchange proteins (recombinases) on single-stranded DNA.


go_id: GO:0097520
term: nucleotide-excision repair, preincision complex
ontology: CC
definition:
A multiprotein complex involved in damage recognition, DNA helix unwinding, and endonucleolytic cleavage at the site of DNA damage.


go_id: GO:0097522
term: protein-DNA ISRE complex
ontology: CC
definition:
A protein-DNA complex formed through interaction of the protein(s) with an interferon-stimulated response element (ISRE) in the DNA.


go_id: GO:0097526
term: spliceosomal tri-snRNP complex
ontology: CC
definition:
A spliceosomal snRNP complex that is formed by the association of the U4/U6 (or U4atac/U6atac) snRNP with the U5 snRNP.


go_id: GO:0097527
term: necroptotic signaling pathway
ontology: BP
definition:
The series of molecular signals which triggers the necroptotic death of a cell. The pathway starts with reception of a signal, is characterized by activation of receptor-interacting serine/threonine-protein kinase 1 and/or 3 (RIPK1/3, also called RIP1/3), and ends when the execution phase of necroptosis is triggered.


go_id: GO:0097528
term: execution phase of necroptosis
ontology: BP
definition:
A stage of the necroptotic process that starts after a necroptotic signal has been relayed to the execution machinery. Key steps of the execution phase are swelling of organelles, minor ultrastructural modifications of the nucleus (specifically, dilatation of the nuclear membrane and condensation of chromatin into small, irregular, circumscribed patches) and increased cell volume (oncosis), culminating in the disruption of the plasma membrane and subsequent loss of intracellular contents. The execution phase ends when the cell has died.


go_id: GO:0097532
term: stress response to acid chemical
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.


go_id: GO:0097533
term: cellular stress response to acid chemical
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in cellular homeostasis caused by the chemical structure of the anion portion of a dissociated acid (rather than the acid acting as a proton donor). The acid chemical may be in gaseous, liquid or solid form.


go_id: GO:0097534
term: lymphoid lineage cell migration
ontology: BP
definition:
The orderly movement of a lymphoid lineage cell from one site to another. A lymphoid lineage cell, also called a lymphoid lineage restricted progenitor cell, is a progenitor cell restricted to the lymphoid lineage.


go_id: GO:0097535
term: lymphoid lineage cell migration into thymus
ontology: BP
definition:
The movement of a lymphoid lineage cell (also called a lymphoid lineage restricted progenitor cell) into the thymus. Lymphoid lineage cells enter and exit the thymus several times as part of this process.


go_id: GO:0097537
term: Y-shaped link
ontology: CC
definition:
A Y-shaped protein complex in the ciliary transition zone that connects the cilium axoneme to the ciliary necklace. Both protein sorting and protein gating occur at this point in the cilium allowing some, but not all proteins to enter the cilium.


go_id: GO:0097538
term: ciliary necklace
ontology: CC
definition:
A protein complex located on the cilium membrane in the ciliary transition zone; it is connected to the cilium axoneme via Y-shaped links.


go_id: GO:0097539
term: ciliary transition fiber
ontology: CC
definition:
A nine-bladed, propeller-like protein complex that links the distal end of the basal body and the cilium to the plasma membrane. Functions in protein sorting and gating (i.e. active and passive transport of proteins in and out of the cilium).


go_id: GO:0097540
term: axonemal central pair
ontology: CC
definition:
Part of the axoneme consisting of the inner two microtubule doublets of the 9+2 axoneme occurring in most motile cilia.


go_id: GO:0097541
term: axonemal basal plate
ontology: CC
definition:
Part of the axoneme consisting of a highly electron-dense region at the distal end of the ciliary transition zone within the axonemal lumen at which the axonemal central pair of microtubules is connected to the rest of the axonemal structure.


go_id: GO:0097542
term: ciliary tip
ontology: CC
definition:
Part of the cilium where the axoneme ends. The ciliary tip has been implicated in ciliary assembly and disassembly, as well as signal transduction.


go_id: GO:0097543
term: ciliary inversin compartment
ontology: CC
definition:
Proximal part of the ciliary shaft to which the inversin protein (also called Inv) specifically localizes. The inversin compartment appears to have a different protein composition than the rest of the cilium, although there is no structure that separates it form the distal part of the cilium.


go_id: GO:0097544
term: ciliary shaft
ontology: CC
definition:
The mid part of a cilium between the ciliary base and ciliary tip that extends into the extracellular space.


go_id: GO:0097545
term: axonemal outer doublet
ontology: CC
definition:
Part of an axoneme consisting in a doublet microtubule. Nine of these outer doublets form the 9+0 axoneme, while the 9+2 axoneme also contains a central pair. Dynein arms attached to the doublets provide the mechanism of movement of the cilium.


go_id: GO:0097546
term: ciliary base
ontology: CC
definition:
Area of the cilium (also called flagellum) where the basal body and the axoneme are anchored to the plasma membrane. The ciliary base encompasses the distal part of the basal body, transition fibers and transition zone and is structurally and functionally very distinct from the rest of the cilium. In this area proteins are sorted and filtered before entering the cilium, and many ciliary proteins localize specifically to this area.


go_id: GO:0097547
term: synaptic vesicle protein transport vesicle
ontology: CC
definition:
A cytoplasmic vesicle composed of both tubulovesicular and clear core vesicles that transport synaptic vesicle-associated proteins. Proteins carried by synaptic vesicle protein transport vesicles (STVs) include synaptophysin, synapsin Ia, synaptotagmin and synaptobrevin/vesicle-associated membrane protein 2 (VAMP2). STVs are packaged via the trans-Golgi network before being transported through the axon.


go_id: GO:0097550
term: transcription preinitiation complex
ontology: CC
definition:
A protein-DNA complex composed of proteins binding promoter DNA to form the transcriptional preinitiation complex (PIC), the formation of which is a prerequisite for transcription.


go_id: GO:0097551
term: mitochondrial double-strand break repair
ontology: BP
definition:
The repair of double-strand breaks in mitochondrial DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix.


go_id: GO:0097552
term: mitochondrial double-strand break repair via homologous recombination
ontology: BP
definition:
The repair of a double-strand break in mitochondrial DNA in which the broken DNA molecule is repaired using homologous sequences.


go_id: GO:0097553
term: calcium ion transmembrane import into cytosol
ontology: BP
definition:
A process in which a calcium ion is transported from one side of a membrane to the other into the cytosol by means of some agent such as a transporter or pore.


go_id: GO:0097554
term: left anterior flagellum
ontology: CC
definition:
A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the left anterior basal body, extends laterally through the cytoplasm, crosses the right anterior axoneme, and exits as a membrane-bound flagellum on the anterior left side of the cell.


go_id: GO:0097555
term: right anterior flagellum
ontology: CC
definition:
A cilium (also called flagellum) found in Giardia species (trophozoite stage). It originates at the right anterior basal body, extends laterally through the cytoplasm, crosses the left anterior axoneme, and exits as a membrane-bound flagellum on the anterior right side of the cell.


go_id: GO:0097556
term: left posteriolateral flagellum
ontology: CC
definition:
A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the left anterior boundary of the lateral shield and the left lateral region of the funis before exiting at the left lateral region of the cell body.


go_id: GO:0097557
term: right posteriolateral flagellum
ontology: CC
definition:
A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right posteriolateral basal body and extends cytoplasmically toward the cell posterior, marking the right anterior boundary of the lateral shield and the right lateral region of the funis before exiting at the right lateral region of the cell body.


go_id: GO:0097558
term: left ventral flagellum
ontology: CC
definition:
A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left ventral basal body and exits the cell body proximally and dorsal to the ventral disc.


go_id: GO:0097559
term: right ventral flagellum
ontology: CC
definition:
A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right ventral basal body and exits the cell body proximally and dorsal to the ventral disc.


go_id: GO:0097560
term: left caudal flagellum
ontology: CC
definition:
A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the left caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body.


go_id: GO:0097561
term: right caudal flagellum
ontology: CC
definition:
A cilium (also called flagellum) found in Giardia species (trophozoite stage). It is nucleated by the right caudal basal body, extending cytoplasmically and exiting at the posterior end of the cell body.


go_id: GO:0097562
term: left lateral basal body pair
ontology: CC
definition:
Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the anterior and ventral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally.


go_id: GO:0097563
term: left middle basal body pair
ontology: CC
definition:
Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the caudal and posteriolateral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally.


go_id: GO:0097564
term: right lateral basal body pair
ontology: CC
definition:
Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the anterior and ventral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally.


go_id: GO:0097565
term: right middle basal body pair
ontology: CC
definition:
Set of two basal bodies found in Giardia species (trophozoite stage). It comprises the caudal and posteriolateral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally.


go_id: GO:0097566
term: left tetrad
ontology: CC
definition:
Set of four basal bodies found in Giardia species (trophozoite stage). It comprises the left lateral basal body pair and the left middle basal body pair (i.e. the anterior, ventral, caudal and posteriolateral basal bodies located to the right of the left nucleus of the trophozoite when viewed dorsally).


go_id: GO:0097567
term: right tetrad
ontology: CC
definition:
Set of four basal bodies found in Giardia species (trophozoite stage). It comprises the right lateral basal body pair and the right middle basal body pair (i.e. the anterior, ventral, caudal and posteriolateral basal bodies located to the left of the right nucleus of the trophozoite when viewed dorsally).


go_id: GO:0097568
term: median body
ontology: CC
definition:
A non-membrane bound, semi-organized microtubule array of unknown function found in Giardia species (trophozoite stage). It is located on the dorsal side of the trophozoite, slightly posterior to the ventral disc.


go_id: GO:0097569
term: lateral shield
ontology: CC
definition:
Region of the ventral side of the cell body found in Giardia species (trophozoite stage). It is located posterior on either side of the ventral groove; the upper boundary is the ventral disc, and the lower boundary is marked by the posteriolateral flagella.


go_id: GO:0097570
term: cyst wall
ontology: CC
definition:
The specialized envelope lying outside the cell membrane of a cyst. A cyst is a resting or dormant stage of a microorganism, usually a bacterium or a protist or rarely an invertebrate animal, that helps the organism to survive in unfavorable environmental conditions. In protists such as protozoan parasites alternating cystic- and non-cystic stages, the cyst wall is usually composed of carbohydrates and proteins.


go_id: GO:0097571
term: left nucleus
ontology: CC
definition:
One of the two nuclei found in Giardia species (trophozoite stage). It is located on the left side of the cell when viewed from the dorsal side.


go_id: GO:0097572
term: right nucleus
ontology: CC
definition:
One of the two nuclei found in Giardia species (trophozoite stage). It is located on the right side of the cell when viewed from the dorsal side.


go_id: GO:0097573
term: glutathione oxidoreductase activity
ontology: MF
definition:
Catalysis of the reaction: protein-S-S-glutathione + glutathione-SH = protein-SH + glutathione-S-S-glutathione.


go_id: GO:0097574
term: lateral part of cell
ontology: CC
definition:
The region of a polarized cell other than its tips or ends (in some cell types, one end may be called the apex and the other the base). For example, in a polarized epithelial cell, the lateral part includes the cell sides which interface adjacent cells.


go_id: GO:0097576
term: vacuole fusion
ontology: BP
definition:
Merging of two or more vacuoles, or of vacuoles and vesicles within a cell to form a single larger vacuole.


go_id: GO:0097577
term: sequestering of iron ion
ontology: BP
definition:
The process of binding or confining iron ions such that they are separated from other components of a biological system.


go_id: GO:0097578
term: sequestering of copper ion
ontology: BP
definition:
The process of binding or confining copper ions such that they are separated from other components of a biological system.


go_id: GO:0097579
term: extracellular sequestering of copper ion
ontology: BP
definition:
The process of binding or confining copper ions in an extracellular area such that they are separated from other components of a biological system.


go_id: GO:0097580
term: intracellular sequestering of copper ion
ontology: BP
definition:
The process of binding or confining copper ions in an intracellular area such that they are separated from other components of a biological system.


go_id: GO:0097581
term: lamellipodium organization
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a lamellipodium. A lamellipodium is a thin sheetlike process extended by the leading edge of a crawling fibroblast; contains a dense meshwork of actin filaments.


go_id: GO:0097582
term: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt2p dimer complex
ontology: CC
definition:
A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt2p.


go_id: GO:0097583
term: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt1p-Pmt3p dimer complex
ontology: CC
definition:
A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt1p-Pmt3p.


go_id: GO:0097584
term: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt2p dimer complex
ontology: CC
definition:
A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt2p.


go_id: GO:0097585
term: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt5p-Pmt3p dimer complex
ontology: CC
definition:
A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt5p-Pmt3p.


go_id: GO:0097586
term: dolichyl-phosphate-mannose-protein mannosyltransferase Pmt4p homodimer complex
ontology: CC
definition:
A protein dimer complex that possesses dolichyl-phosphate-mannose-protein mannosyltransferase activity and, in S. cerevisiae, is composed of Pmt4p.


go_id: GO:0097587
term: MutLgamma complex
ontology: CC
definition:
A heterodimer involved in the recognition of base-base and small insertion/deletion mismatches. In S. cerevisiae the complex consists of two subunits, Mlh1 and Mlh3.


go_id: GO:0097589
term: archaeal-type flagellum
ontology: CC
definition:
A non-membrane-bounded organelle superficially similar to a bacterial-type flagellum; they both consist of filaments extending outside the cell, and rotate to propel the cell, but the archaeal flagella (also called archaella) have a unique structure which lacks a central channel. Similar to bacterial type IV pilins, the archaeal flagellins (archaellins) are made with class 3 signal peptides and they are processed by a type IV prepilin peptidase-like enzyme. The archaellins are typically modified by the addition of N-linked glycans which are necessary for proper assembly and/or function.


go_id: GO:0097590
term: archaeal-type flagellum-dependent cell motility
ontology: BP
definition:
Cell motility due to the motion of one or more archaeal-type flagella. An archaeal-type flagellum (also called archaellum) is a non-membrane-bounded organelle superficially similar to a bacterial-type flagellum, but having a different molecular structure and lacking a central channel.


go_id: GO:0097591
term: ventral disc lateral crest
ontology: CC
definition:
Fibrillar repetitive structure surrounding the ventral disc edge in Giardia species (trophozoite stage). The composition of the lateral crest is not fully known yet.


go_id: GO:0097592
term: ventral disc overlap zone
ontology: CC
definition:
A region of the ventral disc of Giardia species (trophozoite stage) where two portions of the same array of microtubules overlap (the microtubule array makes a complete circle and overlaps on itself).


go_id: GO:0097593
term: ventral disc microtubule array
ontology: CC
definition:
A part of the ventral disc of Giardia species (trophozoite stage) consisting of a spiral array of microtubules linked to the ventral membrane. These microtubules form the base of the ventral disc dorsal microribbons that extend nearly perpendicular from the membrane.


go_id: GO:0097594
term: ventral disc dorsal microribbon
ontology: CC
definition:
Trilaminar structure extending perpendicularly into the cytoplasm along the length of ventral disc microtubules in Giardia species (trophozoite stage). Constituents of dorsal microribbons (also called dorsal ribbons or microribbons) include alpha-coiled-helix proteins approximately 29 to 38 kDa in size. These proteins line the edges of the microribbons but are not found in microtubules. Tubulins are not found in microribbons.


go_id: GO:0097595
term: ventral disc crossbridge
ontology: CC
definition:
Structure horizontally linking adjacent microribbons of the ventral disc in Giardia species (trophozoite stage). The composition of crossbridges is not fully known yet.


go_id: GO:0097596
term: ventral disc supernumerary microtubule array
ontology: CC
definition:
A partial left-handed spiral array of microtubules that lies generally dorsal to the main ventral disc microtubule array in Giardia species (trophozoite stage).


go_id: GO:0097597
term: ventral disc
ontology: CC
definition:
Specialized organelle found in Giardia species (trophozoite stage) and characterized by a spiral array of microtubules and microtubule-associated structures including dorsal microribbons and crossbridges. The edge of the ventral disc narrows into a lateral crest. The ventral disk mediates mechanical attachment of the trophozoite to the host's intestinal wall, and contains the contractile proteins actinin, alpha-actinin, myosin, and tropomyosin working towards contraction of the disk involved in adherence.


go_id: GO:0097598
term: sperm cytoplasmic droplet
ontology: CC
definition:
A small amount of cytoplasm surrounded by a cell membrane that is generally retained in spermatozoa after spermiogenesis, when the majority of the cytoplasm is phagocytosed by Sertoli cells to produce what are called residual bodies. Initially, the droplet is located at the neck just behind the head of an elongated spermatid. During epididymal transit, the cytoplasmic droplet migrates caudally to the annulus at the end of the midpiece; the exact position and time varies by species. The cytoplasmic droplet consists of lipids, lipoproteins, RNAs, a variety of hydrolytic enzymes, receptors, ion channels, and Golgi-derived vesicles. The droplet may be involved in regulatory volume loss (RVD) at ejaculation, and in most species, though not in humans, the cytoplasmic droplet is lost at ejaculation. Note that the cytoplasmic droplet is distinct from 'excessive residual cytoplasm' that sometimes remains in epididymal spermatozoa, particularly when spermiogenesis has been disrupted.


go_id: GO:0097600
term: exoxylanase activity
ontology: MF
definition:
A xylanase activity that acts on one of the ends of a xylan polymer which does not contain side chains.


go_id: GO:0097602
term: cullin family protein binding
ontology: MF
definition:
Binding to a member of the cullin family, hydrophobic proteins that act as scaffolds for ubiquitin ligases (E3).


go_id: GO:0097603
term: temperature-gated ion channel activity
ontology: MF
definition:
Enables the transmembrane transfer of an ion by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism).


go_id: GO:0097604
term: temperature-gated cation channel activity
ontology: MF
definition:
Enables the transmembrane transfer of a cation by a channel that opens in response to a temperature stimulus (e.g. exposure to a temperature range different than the optimal temperature for that organism).


go_id: GO:0097608
term: transverse flagellum
ontology: CC
definition:
A motile cilium found in dinoflagellates. It coils around the cell and provides the forward thrust for motility. It is often contained in a furrow called the cingulum, and emerges from a flagellar pore located in the cingulum.


go_id: GO:0097609
term: longitudinal flagellum
ontology: CC
definition:
A motile cilium found in dinoflagellates. It trails the cell and acts as a steering rudder. It is often partially contained in a furrow called the sulcus, and emerges from a flagellar pore located in the sulcus.


go_id: GO:0097610
term: cell surface furrow
ontology: CC
definition:
A furrow that may be found on the cell surface. Examples include the cingulum and sulcus found in some dinoflagellates.


go_id: GO:0097612
term: dinoflagellate sulcus
ontology: CC
definition:
A cell surface furrow that occurs on the ventral side of a dinoflagellate cell. It partially houses the longitudinal flagellum. The sulcus intersects with the cingulum on the ventral side of a dinoflagellate cell.


go_id: GO:0097613
term: dinoflagellate epicone
ontology: CC
definition:
The part of a dinoflagellate cell above the cingulum; also referred to as the anterior portion of a dinoflagellate cell. It is separated from the hypocone by the cingulum.


go_id: GO:0097614
term: dinoflagellate hypocone
ontology: CC
definition:
The part of a dinoflagellate cell below the cingulum; also referred to as the posterior portion of a dinoflagellate cell. It is separated from the epicone by the cingulum.


go_id: GO:0097615
term: modulation by host of symbiont type IV pilus-dependent motility
ontology: BP
definition:
The process in which an organism effects a change in the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.


go_id: GO:0097616
term: positive regulation by host of symbiont type IV pilus-dependent motility
ontology: BP
definition:
Any process in which an organism activates, maintains or increases the frequency, rate or extent of the type IV pilus-dependent motility of a symbiont organism (i.e. the controlled movement of a bacterial cell which is dependent on the presence of type IV pili, and which includes social gliding motility and twitching motility). The symbiont is defined as the smaller of the organisms involved in a symbiotic interaction.


go_id: GO:0097618
term: dinoflagellate sulcal notch
ontology: CC
definition:
A dinoflagellate sulcus that extends all the way to the posterior end of the cell (also known as antapex). The presence of a sulcal notch makes the dinoflagellate hypocone appear bilobed.


go_id: GO:0097619
term: PTEX complex
ontology: CC
definition:
A protein complex that acts as a protein trafficking machinery and is responsible for the export of proteins across the parasitophorous (symbiont-containing) vacuolar membrane and into the human host cell. The PTEX complex is located in the vacuole membrane. It is ATP-powered, and comprises heat shock protein 101 (HSP101; a ClpA/B-like ATPase from the AAA+ superfamily, of a type commonly associated with protein translocons), a parasite protein termed PTEX150, and exported protein 2 (EXP2). EXP2 is the potential channel, as it is the membrane-associated component of the core PTEX complex. Two other proteins, PTEX88 and thioredoxin 2 (TRX2), were also identified as PTEX components.


go_id: GO:0097620
term: (R)-mandelate dehydrogenase activity
ontology: MF
definition:
Catalysis of the reaction: (R)-2-hydroxy-2-phenylacetate + acceptor = phenylglyoxylate + reduced acceptor.


go_id: GO:0097622
term: cytoplasmic translational elongation through polyproline stretches
ontology: BP
definition:
The successive addition of amino acid residues to a nascent polypeptide chain, proceeding through regions of multiple repeated proline codons, during protein biosynthesis in the cytoplasm.


go_id: GO:0097623
term: potassium ion export across plasma membrane
ontology: BP
definition:
The directed movement of potassium ions from inside of a cell, across the plasma membrane and into the extracellular region.


go_id: GO:0097625
term: low-affinity basic amino acid transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of basic amino acids from one side of a membrane to the other. Basic amino acids have a pH above 7. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.


go_id: GO:0097626
term: low-affinity L-arginine transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of L-arginine from one side of a membrane to the other. In low-affinity transport the transporter is able to bind the solute only if it is present at very high concentrations.


go_id: GO:0097627
term: high-affinity L-ornithine transmembrane transporter activity
ontology: MF
definition:
Enables the transfer of L-ornithine from one side of a membrane to the other. In high-affinity transport the transporter is able to bind the solute even if it is only present at very low concentrations.


go_id: GO:0097629
term: extrinsic component of omegasome membrane
ontology: CC
definition:
The component of the omegasome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0097630
term: intrinsic component of omegasome membrane
ontology: CC
definition:
The component of the omegasome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0097631
term: integral component of omegasome membrane
ontology: CC
definition:
The component of the omegasome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0097632
term: extrinsic component of phagophore assembly site membrane
ontology: CC
definition:
The component of the phagophore assembly site membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0097633
term: intrinsic component of phagophore assembly site membrane
ontology: CC
definition:
The component of the phagophore assembly site membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0097634
term: integral component of phagophore assembly site membrane
ontology: CC
definition:
The component of the phagophore assembly site membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0097635
term: extrinsic component of autophagosome membrane
ontology: CC
definition:
The component of the autophagosome membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.


go_id: GO:0097636
term: intrinsic component of autophagosome membrane
ontology: CC
definition:
The component of the autophagosome membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0097637
term: integral component of autophagosome membrane
ontology: CC
definition:
The component of the autophagosome membrane consisting of the gene products and protein complexes having at least some part of their peptide sequence embedded in the hydrophobic region of the membrane.


go_id: GO:0097638
term: L-arginine import across plasma membrane
ontology: BP
definition:
The directed movement of L-arginine from outside of a cell, across the plasma membrane and into the cytosol.


go_id: GO:0097639
term: L-lysine import across plasma membrane
ontology: BP
definition:
The directed movement of L-lysine from outside of a cell, across the plasma membrane and into the cytosol.


go_id: GO:0097640
term: L-ornithine import across plasma membrane
ontology: BP
definition:
The directed movement of L-ornithine from outside of a cell, across the plasma membrane and into the cytosol.


go_id: GO:0097641
term: alpha-ketoglutarate-dependent xanthine dioxygenase activity
ontology: MF
definition:
Catalysis of the reaction: 2-oxoglutarate (alpha-ketoglutarate) + O2 + xanthine = CO2 + succinate + urate.


go_id: GO:0097642
term: calcitonin family receptor activity
ontology: MF
definition:
Combining with any member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) to initiate a change in cell activity.


go_id: GO:0097644
term: calcitonin family binding
ontology: MF
definition:
Binding to a member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)).


go_id: GO:0097646
term: calcitonin family receptor signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway initiated by an extracellular member of the calcitonin family (e.g. adrenomedullin, adrenomedullin 2 (intermedin), amylin, calcitonin and calcitonin gene-related peptides (CGRPs)) binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


go_id: GO:0097647
term: amylin receptor signaling pathway
ontology: BP
definition:
A G protein-coupled receptor signaling pathway initiated by amylin binding to its receptor on the surface of a target cell, and ending with the regulation of a downstream cellular process.


go_id: GO:0097649
term: A axonemal microtubule
ontology: CC
definition:
A complete microtubule with 13 protofilaments that fuses with an incomplete microtubule called B tubule (containing 10 protofilaments only) to form an axonemal outer doublet. Inner and outer dynein arms, as well as the radial spoke, are attached to the A tubule.


go_id: GO:0097650
term: B axonemal microtubule
ontology: CC
definition:
An incomplete microtubule containing 10 protofilaments that fuses with a complete microtubule called A tubule (containing 13 protofilaments) to form an axonemal outer doublet.


go_id: GO:0097651
term: phosphatidylinositol 3-kinase complex, class I
ontology: CC
definition:
A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme, plus one or more adaptor proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. The class I PI3K subfamily of genes comprises members in vertebrates, worm and fly, but none in yeast.


go_id: GO:0097652
term: phosphatidylinositol 3-kinase complex, class II
ontology: CC
definition:
A phosphatidylinositol 3-kinase complex that contains a catalytic subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme and one or more adaptor proteins. There is no known obligatory regulatory subunit. The class II PI3K (PI3KC2) subfamily of genes has members in vertebrates, worm and fly, but none in yeast.


go_id: GO:0097653
term: unencapsulated part of cell
ontology: CC
definition:
The part of a cell encompassing the intracellular environment and the plasma membrane; it excludes any external encapsulating structures.


go_id: GO:0097654
term: platelet SNARE complex
ontology: CC
definition:
A SNARE complex that is capable of fusing intracellular vesicles to the plasma membrane of platelets for exocytosis of alpha-granules or dense granules. Contains isoforms of VAMP, SNAP and syntaxin proteins. Ternary SNARE complexes interact in a circular array to form ring complexes or channels around the membrane fusion. A common composition in human is VAMP-8, SNAP-23 and syntaxin-2 or -4.


go_id: GO:0097655
term: serpin family protein binding
ontology: MF
definition:
Binding to a member of the serpin protein family (serine protease inhibitors or classified inhibitor family I4). Serpins are a broadly distributed family of protease inhibitors that use a conformational change to inhibit target enzymes. They are central in controlling many important proteolytic cascades. The majority of serpins inhibit serine proteases, but serpins that inhibit caspases and papain-like cysteine proteases have also been identified. Rarely, serpins perform a non-inhibitory function; for example, several human serpins function as hormone transporters and certain serpins function as molecular chaperones or tumor suppressors.


go_id: GO:0097656
term: cell-cell self recognition
ontology: BP
definition:
A cell-cell recognition process by which a cell distinguishes between self and non self during cooperative behavior, such as early development.


go_id: GO:0097657
term: 3',5'-nucleotide bisphosphate phosphatase activity
ontology: MF
definition:
Catalysis of the reaction: 3',5'-nucleoside bisphosphate + H20 = 5'-nucleoside monophosphate + phosphate.


go_id: GO:0097658
term: Asi complex
ontology: CC
definition:
A nuclear ubiquitin ligase multiprotein complex located in the inner nuclear membrane (INM) that recognizes and ubiquitinates misfolded INM proteins and also some proteins involved in sterol biosynthesis, during ER-associated protein degradation (ERAD). In S. cerevisiae, this complex contains the ubiquitin ligases Asi1p and Asi3p.


go_id: GO:0097663
term: SCF-Dia2/Pof3 ubiquitin ligase complex
ontology: CC
definition:
An SCF ubiquitin ligase complex in which the F-box protein is Dia2 in S. cerevisiae (Pof3 in S. pombe).


go_id: GO:0097664
term: SCF-Grr1/Pof2 ubiquitin ligase complex
ontology: CC
definition:
An SCF ubiquitin ligase complex in which the F-box protein is Grr1 in S. cerevisiae (Pof2 in S. pombe).


go_id: GO:0097666
term: SCF-Met30/Pof1 ubiquitin ligase complex
ontology: CC
definition:
An SCF ubiquitin ligase complex in which the F-box protein is Met30 in S. cerevisiae (Pof1 in S pombe).


go_id: GO:0097667
term: SCF-Rcy1/Pof6 ubiquitin ligase complex
ontology: CC
definition:
An SCF ubiquitin ligase complex in which the F-box protein is Rcy1 in S. cerevisiae (Pof6 in S. pombe).


go_id: GO:0097668
term: SCF-Saf1/Pof9 ubiquitin ligase complex
ontology: CC
definition:
An SCF ubiquitin ligase complex in which the F-box protein is Saf1 in S. cerevisiae (Pof9 in S. pombe).


go_id: GO:0097670
term: SCF-Ufo1/Pof10 ubiquitin ligase complex
ontology: CC
definition:
An SCF ubiquitin ligase complex in which the F-box protein is Ufo1 in S. cerevisiae (Pof10 in S. pombe).


go_id: GO:0097672
term: SCF-Pof5 ubiquitin ligase complex
ontology: CC
definition:
An SCF ubiquitin ligase complex in which the F-box protein is Pof5 in S. pombe (YDR306C in S. cerevisiae).


go_id: GO:0097675
term: SCF-Hrt3/Pof7 ubiquitin ligase complex
ontology: CC
definition:
An SCF ubiquitin ligase complex in which the F-box protein is Hrt3 in S. cerevisiae (Pof7 in S. pombe).


go_id: GO:0097676
term: histone H3-K36 dimethylation
ontology: BP
definition:
The modification of histone H3 by addition of two methyl groups to lysine at position 36 of the histone.


go_id: GO:0097677
term: STAT family protein binding
ontology: MF
definition:
Binding to a member of the signal transducers and activators of transcription (STAT) protein family. STATs are, as the name indicates, both signal transducers and transcription factors. STATs are activated by cytokines and some growth factors and thus control important biological processes including cell growth, cell differentiation, apoptosis and immune responses.


go_id: GO:0097678
term: SOCS family protein binding
ontology: MF
definition:
Binding to a member of the suppressor of cytokine signaling (SOCS) family of proteins. SOCS represent an important mechanism to extinguish cytokine and growth factor receptor signaling. Individual SOCS proteins are typically induced by specific cytokines and growth factors, thereby generating a negative feedback loop. SOCS proteins have important functions in development and homeostasis, and in disease, particularly tumor suppression and anti-inflammatory functions.


go_id: GO:0097680
term: double-strand break repair via classical nonhomologous end joining
ontology: BP
definition:
An instance of double-strand break repair via nonhomologous end joining that requires a number of factors important for V(D)J recombination, including the KU70/80 heterodimer (KU), XRCC4, ligase IV, and DNA-PKcs in mammals. It does not produce translocations (as opposed to the alternative nonhomologous end joining).


go_id: GO:0097681
term: double-strand break repair via alternative nonhomologous end joining
ontology: BP
definition:
An instance of double-strand break repair via nonhomologous end joining that is independent of factors important for V(D)J recombination (as opposed to classical nonhomologous end joining). It often results in a deletion with microhomology (i.e. 5-25bp homology) at the repair junction. Among different subclasses of nonhomologous end joining (NHEJ), alternative NHEJ appears to play a significant role in the etiology of mutations that arise during cancer development and treatment.


go_id: GO:0097682
term: intracellular phosphatidylinositol-3,5-bisphosphate-sensitive cation channel activity
ontology: MF
definition:
Enables the transmembrane transfer of cations by a channel that opens when phosphatidylinositol-3,5-bisphosphate has been bound by the channel complex or one of its constituent parts.


go_id: GO:0097685
term: dinoflagellate apical groove
ontology: CC
definition:
A cell surface furrow (or groove) found on a dinoflagellate apex. It typically loops around the apex.


go_id: GO:0097688
term: glutamate receptor clustering
ontology: BP
definition:
The neurotransmitter-gated ion channel clustering process in which glutamate receptors are localized to distinct domains in the cell membrane.


go_id: GO:0097691
term: bacterial extracellular vesicle
ontology: CC
definition:
Small membrane vesicle (< 1 um) that buds off a prokaryotic cell plasma membrane, able to carry proteins, phospholipids, lipopolysaccharides, nucleic acids, viruses, and more. Important in intercellular communication and pathogenesis; can exist within host cells.


go_id: GO:0097692
term: histone H3-K4 monomethylation
ontology: BP
definition:
The modification of histone H3 by addition of one methyl group to lysine at position 4 of the histone.


go_id: GO:0097693
term: ocelloid
ontology: CC
definition:
Eye-like subcellular structure found in dinoflagellates (a large group of single-celled eukaryotes). Consists of subcellular analogues to a cornea, lens, iris, and retina. Ocelloids are built from pre-existing organelles, including a cornea-like layer made of mitochondria and a retinal body made of anastomosing plastids.


go_id: GO:0097695
term: establishment of protein-containing complex localization to telomere
ontology: BP
definition:
The directed movement of a protein-containing macromolecular complex to a specific location in the telomeric region of a chromosome.


go_id: GO:0097696
term: receptor signaling pathway via STAT
ontology: BP
definition:
An intracellular signal transduction process in which STAT proteins (Signal Transducers and Activators of Transcription) convey a signal to trigger a change in the activity or state of a cell. The STAT cascade begins with receptor activation followed by activation of STAT proteins by kinases. It proceeds through STA dimerization and subsequent nuclear translocation of STAT proteins, and ends with regulation of target gene expression by STAT proteins.


go_id: GO:0097697
term: tRNA 5-carboxymethoxyuridine methyltransferase activity
ontology: MF
definition:
Catalysis of the transfer of a methyl group from S-adenosylmethionine to a 5-carboxymethoxy-modified uridine residue in a tRNA molecule.


go_id: GO:0097698
term: telomere maintenance via base-excision repair
ontology: BP
definition:
A telomere maintenance process that occurs by base-excision repair of telomeric DNA in response to DNA damage. Telomeric sequences are particularly susceptible to oxidative DNA damage, due to their G-rich nature.


go_id: GO:0097701
term: response to pulsatile fluid shear stress
ontology: BP
definition:
Any response to fluid shear stress where the fluid is flowing across a solid surface with periodic variations. For example, the endothelium in straight parts of the artery tree is subjected to pulsatile shear stress with a significant forward direction, which is believed to be an important physiological stimulus enhancing vessel compliance and conferring anti-thrombotic, anti-adhesive, and anti-inflammatory effects.


go_id: GO:0097702
term: response to oscillatory fluid shear stress
ontology: BP
definition:
Any response to fluid shear stress where the fluid is moving across a solid surface with an oscillatory flow. Disturbed flow patterns at the arterial bifurcations and curvatures may cause endothelial dysfunction, which initiates atherosclerosis.


go_id: GO:0097707
term: ferroptosis
ontology: BP
definition:
A programmed cell death characterized morphologically by the presence of smaller than normal mitochondria with condensed mitochondrial membrane densities, reduction or vanishing of mitochondria crista, and outer mitochondrial membrane rupture. Activation of mitochondrial voltage-dependent anion channels and mitogen-activated protein kinases, upregulation of endoplasmic reticulum stress, and inhibition of cystine/glutamate antiporter are involved in the induction of ferroptosis. This process is characterized by the accumulation of lipid peroxidation products and lethal reactive oxygen species (ROS) derived from iron metabolism. Glutathione peroxidase 4 (GPX4), heat shock protein beta-1, and nuclear factor erythroid 2-related factor 2 function as negative regulators of ferroptosis by limiting ROS production and reducing cellular iron uptake, respectively. In contrast, NADPH oxidase and p53 act as positive regulators of ferroptosis by promotion of ROS production and inhibition of expression of SLC7A11 (a specific light-chain subunit of the cystine/glutamate antiporter), respectively. Misregulated ferroptosis has been implicated in multiple physiological and pathological processes.


go_id: GO:0097709
term: connective tissue replacement
ontology: BP
definition:
The series of events leading to growth of connective tissue when loss of tissues that are incapable of regeneration occurs, or when fibrinous exudate cannot be adequately cleared.


go_id: GO:0097710
term: viral terminase, small subunit
ontology: CC
definition:
The part of the viral terminase complex that acts as a phage DNA-recognition component and regulates the activity of the large subunit. The small subunit usually assembles as a heterooligomer with the large subunit.


go_id: GO:0097711
term: ciliary basal body-plasma membrane docking
ontology: BP
definition:
The docking of a cytosolic centriole/basal body to the plasma membrane via the ciliary transition fibers. In some species this may happen via an intermediate step, by first docking to the ciliary vesicle via the ciliary transition fibers. The basal body-ciliary vesicle then relocates to the plasma membrane, followed by the ciliary vesicle fusing with the plasma membrane, effectively attaching the basal body to the plasma membrane.


go_id: GO:0097712
term: vesicle targeting, trans-Golgi to periciliary membrane compartment
ontology: BP
definition:
The process in which vesicles formed at the trans-Golgi network are directed to the plasma membrane surrounding the base of the cilium, including the ciliary pocket, mediated by molecules at the vesicle membrane and target membrane surfaces.


go_id: GO:0097714
term: response to viscosity
ontology: BP
definition:
Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus.


go_id: GO:0097715
term: cellular response to viscosity
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a viscosity stimulus.


go_id: GO:0097720
term: calcineurin-mediated signaling
ontology: BP
definition:
Any intracellular signal transduction in which the signal is passed on within the cell by activation of a transcription factor as a consequence of dephosphorylation by Ca(2+)-activated calcineurin. The process begins with calcium-dependent activation of the phosphatase calcineurin. Calcineurin is a calcium- and calmodulin-dependent serine/threonine protein phosphatase with a conserved function in eukaryotic species from yeast to humans. In yeast and fungi, calcineurin regulates stress signaling and cell cycle, and sporulation and virulence in pathogenic fungi. In metazoans, calcineurin is involved in cell commitment, organogenesis and organ development and immune function of T-lymphocytes. By a conserved mechanism, calcineurin phosphatase activates fungal Crz1 and mammalian NFATc by dephosphorylation and translocation of these transcription factors to the nucleus to regulate gene expression.


go_id: GO:0097721
term: ciliary vesicle
ontology: CC
definition:
A Golgi-derived vesicle to which the ciliary basal body docks via its transitional fibers. Its membrane is compositionally distinct from Golgi membranes, and will become the ciliary membrane once the ciliary vesicle is fused to the plasma membrane. The ciliary vesicle is thought to be formed by multiple smaller vesicles that attach to the transitional fibers and then fuse to form a larger vesicle.


go_id: GO:0097725
term: histone H3-K79 dimethylation
ontology: BP
definition:
The modification of histone H3 by addition of two methyl groups to lysine at position 79 of the histone.


go_id: GO:0097726
term: LEM domain binding
ontology: MF
definition:
Binding to a LEM domain. The LEM domain (for lamina-associated polypeptide, emerin, MAN1 domain) is present in a group of nuclear proteins that bind chromatin through interaction of the LEM motif with the conserved DNA crosslinking protein, barrier-to-autointegration factor (BAF).


go_id: GO:0097727
term: blepharoplast
ontology: CC
definition:
An intracellular non-membrane-bounded organelle found in multi-ciliated sperm cells of some primitive land plants, and consisting of many radially arranged ninefold symmetric cylinders. The blepharoplast is involved in de novo formation of multiple centrioles; it enlarges and then disintegrates into many procentrioles, which elongate and ultimately nucleate cilia on the surface of the sperm cell.


go_id: GO:0097728
term: 9+0 motile cilium
ontology: CC
definition:
A motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme).


go_id: GO:0097729
term: 9+2 motile cilium
ontology: CC
definition:
A motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).


go_id: GO:0097730
term: non-motile cilium
ontology: CC
definition:
A cilium which may have a variable array of axonemal microtubules but does not contain molecular motors.


go_id: GO:0097731
term: 9+0 non-motile cilium
ontology: CC
definition:
A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets but no central microtubules (and is therefore called a 9+0 axoneme).


go_id: GO:0097732
term: 9+2 non-motile cilium
ontology: CC
definition:
A non-motile cilium where the axoneme has a ring of nine outer microtubule doublets plus two central microtubules (and is therefore called a 9+2 axoneme).


go_id: GO:0097733
term: photoreceptor cell cilium
ontology: CC
definition:
A specialised 9+0 non-motile cilium found in photoreceptor cells. A ciliary transition zone called 'photoreceptor connecting cilium' links the photoreceptor outer segment to the inner segment.


go_id: GO:0097734
term: extracellular exosome biogenesis
ontology: BP
definition:
The assembly and secretion of an extracellular exosome, a membrane-bounded vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane.


go_id: GO:0097735
term: DIM/DIP cell wall layer
ontology: CC
definition:
A section of the Actinobacterium-type cell wall composed of (phenyl)phthiocerol, phthiodiolone, phthiotriol dimycocerosate, diphthioceranate and other compounds.


go_id: GO:0097736
term: aerial mycelium formation
ontology: BP
definition:
The process by which hyphae grow in an upward or outward direction from the surface of the substrate; from there, propagative spores develop in or on characteristic structures that are distinctive of some fungal and bacterial species. The species that form an aerial mycelium develop conidiophores at the ends of the aerial hyphae.


go_id: GO:0097737
term: acquisition of mycelium reproductive competence
ontology: BP
definition:
A maturation process by which an organism acquires the ability to reproduce. In fungi, reproductive competence only occurs in a population of filamentous cells that form a mycelium.


go_id: GO:0097738
term: substrate mycelium formation
ontology: BP
definition:
The process by which, in some fungal species, hyphae grow as a network of invasive thread-like filaments formed from chains of attached cells within a solid or semi-solid substrate.


go_id: GO:0097739
term: negative regulation of ferrichrome biosynthetic process in response to iron
ontology: BP
definition:
Any process that stops, prevents or reduces the rate of ferrichrome biosynthetic process in response to an iron stimulus.


go_id: GO:0097740
term: paraflagellar rod
ontology: CC
definition:
A large lattice-like axial structure found in some flagellated protists which extends alongside the axoneme. Protein components of the paraflagellar rod are likely implicated, among other, in adenine nucleotide signalling and metabolism, and in calcium signalling.


go_id: GO:0097741
term: mastigoneme
ontology: CC
definition:
A hair-like structure covering the flagella found in some algae (heterokonts and cryptophytes). It is approximately 15 nm in diameter, and usually consist of a tubular shaft that itself terminates in smaller hairs. It is composed of glycoproteins and, likely, carbohydrates. Mastigonemes may assist in locomotion by increasing the surface area of a flagellum.


go_id: GO:0097742
term: de novo centriole assembly
ontology: BP
definition:
Centriole assembly in which a centriole arises de novo, rather than by replication from an existing centriole. This process may occur via different mechanisms. Examples include the deuterosome pathway in multicilated epithelial animal cells and formation of centrioles during parthenogenesis in some insects.


go_id: GO:0097743
term: de novo centriole assembly via blepharoplast
ontology: BP
definition:
A de novo centriole assembly process observed in multi-ciliated sperm cells of some primitive land plants, and where centrioles are formed from a blepharoplast, ultimately giving rise to multiple cilia on the sperm surface.


go_id: GO:0097744
term: renal urate salt excretion
ontology: BP
definition:
The elimination of urate salt or uric acid from peritubular capillaries (or surrounding hemolymph in invertebrates) into the renal tubules to be incorporated subsequently into the urine.


go_id: GO:0097745
term: mitochondrial tRNA 5'-end processing
ontology: BP
definition:
The process in which the 5' end of a pre-tRNA molecule is converted to that of a mature tRNA in the mitochondrion.


go_id: GO:0097747
term: RNA polymerase activity
ontology: MF
definition:
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template.


go_id: GO:0097748
term: 3'-5' RNA polymerase activity
ontology: MF
definition:
Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1); the synthesis of RNA from ribonucleotide triphosphates in the presence of a nucleic acid template, via extension of the 5'-end.


go_id: GO:0097749
term: membrane tubulation
ontology: BP
definition:
A membrane organization process resulting in the formation of a tubular projection. This may face inwardly (as in tubular membrane invaginations) or outwardly (as in endosomal tubules).


go_id: GO:0097751
term: spore-bearing structure formation
ontology: BP
definition:
The process of generating a spore-bearing structure. A spore-bearing structure is an anatomical structure that produces new spores.


go_id: GO:0098001
term: receptor-mediated bacteriophage reversible attachment to host cell
ontology: BP
definition:
Process by which a bacteriophage, using its tail fibers, spikes or a baseplate component, initially recognizes and binds to its specific receptor on the host cell surface. This process is reversible and allows the release of a bacteriophage without affecting infection.


go_id: GO:0098002
term: receptor-mediated bacteriophage irreversible attachment to host cell
ontology: BP
definition:
The processes by which a bacteriophage initially commits to infection by binding the host receptor irreversibly. Disruption of the phage:cell complex at this step results in the loss of infective phage virions since the process is characterized by conformational changes of bacteriophage head and tail proteins and injection of bacteriophage proteins into the infected cell.


go_id: GO:0098004
term: virus tail fiber assembly
ontology: BP
definition:
The aggregation, arrangement and bonding together of a set of components to form a virus tail fiber.


go_id: GO:0098006
term: viral DNA genome packaging, headful
ontology: BP
definition:
The encapsulation of the viral genome within the capsid where DNA is packaged into the capsid until the capsid is full.


go_id: GO:0098009
term: viral terminase, large subunit
ontology: CC
definition:
The part of the viral terminase complex that contains the translocase and endonuclease activities and allows the translocation of the phage DNA into the procapsid. The large subunit usually assembles as a heterooligomer with the small subunit.


go_id: GO:0098015
term: virus tail
ontology: CC
definition:
Part of the virion that may be used to recognize, attach and inject the viral genome and accessory proteins into the host cell.


go_id: GO:0098017
term: viral capsid, major subunit
ontology: CC
definition:
The part of the viral capsid that comprises the most common capsomere type. For example, in a T=3 icosahedral capsid, which is composed of 12 pentameric and 20 hexameric capsomeres, the hexameric capsomeres are major subunits.


go_id: GO:0098018
term: viral capsid, minor subunit
ontology: CC
definition:
The part of the viral capsid that comprises the less common capsomere type. For example, in a T=3 icosahedral capsid, which is composed of 12 pentameric and 20 hexameric capsomeres, the pentameric capsomeres are minor subunits.


go_id: GO:0098021
term: viral capsid, decoration
ontology: CC
definition:
Component of the virus capsid (head), located on the outer head surface. Involved in the stabilization of the head structure and usually non-essential.


go_id: GO:0098025
term: virus tail, baseplate
ontology: CC
definition:
Multiprotein component at the distal (head) end of the virus tail to which fibers of tailed viruses may be attached.


go_id: GO:0098026
term: virus tail, tube
ontology: CC
definition:
The internal tube of the contractile tails of some viruses. The virus tail tube is the channel for DNA ejection into the host cytoplasm.


go_id: GO:0098027
term: virus tail, sheath
ontology: CC
definition:
The external contractile envelope of the tail of some viruses. Its contraction ensures ejection of the virus DNA into the host cytoplasm.


go_id: GO:0098029
term: icosahedral viral capsid, spike
ontology: CC
definition:
A short structure attached to an icosahedral virion capsid, and used for attachment to the host cell.


go_id: GO:0098030
term: icosahedral viral capsid, neck
ontology: CC
definition:
A region of constriction located below the head and above the tail sheath of viruses with contractile tails (Myoviridae).


go_id: GO:0098035
term: viral DNA genome packaging via site-specific sequence recognition
ontology: BP
definition:
The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites by a viral terminase.


go_id: GO:0098036
term: viral DNA genome packaging, 3' extended cos packaging
ontology: BP
definition:
The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites to produce 3' protruding ends.


go_id: GO:0098037
term: viral DNA genome packaging, 5' extended cos packaging
ontology: BP
definition:
The encapsulation of the viral DNA genome within the capsid, which proceeds via cleavage of the viral DNA at specific sites to produce 5' protruding ends.


go_id: GO:0098038
term: non-replicative transposition, DNA-mediated
ontology: BP
definition:
Process by which a transposable element is excised from the donor site and integrated at the target site without replication of the element. Also referred to as cut-and-paste transposition.


go_id: GO:0098039
term: replicative transposition, DNA-mediated
ontology: BP
definition:
Process of transposition in which the existing element is replicated and one of the copies is excised and integrated at a new target site. Also referred to as copy-and-paste transposition.


go_id: GO:0098046
term: type V protein secretion system complex
ontology: CC
definition:
A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc).


go_id: GO:0098061
term: viral capsid, internal space
ontology: CC
definition:
The region of a virus contained within the capsid shell, and usually containing the viral genome and accessory proteins.


go_id: GO:0098508
term: endothelial to hematopoietic transition
ontology: BP
definition:
The generation of hematopoietic stem cells from hemogenic endothelial cells by a process that includes tight-junction dissolution and loss of cell polarity followed by delamination from the endothelium.


go_id: GO:0098509
term: sensory perception of humidity
ontology: BP
definition:
The series of events required for an organism to detect some level of humidity in its environment, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process.


go_id: GO:0098510
term: sensory perception of high humidity
ontology: BP
definition:
The series of events required for an organism to detect high environmental humidity, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process.


go_id: GO:0098511
term: sensory perception of low humidity
ontology: BP
definition:
The series of events required for an organism to detect low environmental humidity, convert this detection into a molecular signal, and recognize and characterize the signal. This is a neurological process.


go_id: GO:0098512
term: detection of humidity stimulus involved in sensory perception
ontology: BP
definition:
The series of events in which a humidity stimulus is received and converted into a molecular signal as part of the sensory perception of humidity.


go_id: GO:0098513
term: detection of humidity
ontology: BP
definition:
The series of events in which a humidity stimulus is received and converted into a molecular signal.


go_id: GO:0098514
term: detection of high humidity stimulus involved in sensory perception
ontology: BP
definition:
The series of events in which a high humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of high humidity.


go_id: GO:0098515
term: detection of low humidity stimulus involved in sensory perception
ontology: BP
definition:
The series of events in which a low humidity stimulus is detected and converted into a molecular signal as a part of the sensory detection of low humidity.


go_id: GO:0098520
term: excitatory neuromuscular junction
ontology: CC
definition:
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a post-synaptic potential responsible for muscle contraction.


go_id: GO:0098521
term: inhibitory neuromuscular junction
ontology: CC
definition:
The junction between the axon of a motor neuron and a muscle fiber. In response to the arrival of action potentials, the presynaptic button releases molecules of neurotransmitters into the synaptic cleft. These diffuse across the cleft and transmit the signal to the postsynaptic membrane of the muscle fiber, leading to a change in post-synaptic potential that inhibits muscle contraction.


go_id: GO:0098524
term: neuromuscular junction of somatic muscle myotube
ontology: CC
definition:
A neuromuscular junction in which the target muscle cell is a somatic muscle myotube, such as an arthropod somatic muscle cell.


go_id: GO:0098525
term: excitatory neuromuscular junction of somatic myotube
ontology: CC
definition:
A neuromuscular junction that functions in the excitation of somatic muscle myotubes, such as an arthropod somatic muscle cells.


go_id: GO:0098526
term: inhibitory neuromuscular junction of somatic myotube
ontology: CC
definition:
A neuromuscular junction that functions in the inhibition of somatic muscle myotube contraction. Examples of somatic muscle myotubes include the somatic muscle cells of arthropods.


go_id: GO:0098527
term: neuromuscular junction of somatic muscle
ontology: CC
definition:
A neuromuscular junction in which the target muscle cell is a somatic muscle cell, such as those found in nematodes and arthropods.


go_id: GO:0098528
term: skeletal muscle fiber differentiation
ontology: BP
definition:
The process in which a relatively unspecialized cell acquires specialized features of a skeletal muscle fiber cell. Skeletal muscle fiber differentiation starts with myoblast fusion and the appearance of specific cell markers (this is the cell development step). Then individual skeletal muscle fibers fuse to form bigger myotubes and start to contract.


go_id: GO:0098529
term: neuromuscular junction development, skeletal muscle fiber
ontology: BP
definition:
A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a neuromuscular junction that targets a skeletal muscle fiber.


go_id: GO:0098530
term: positive regulation of strand invasion
ontology: BP
definition:
Any process that increases the rate, frequency or extent of strand invasion. Strand invasion is the process in which the nucleoprotein complex (composed of the broken single-strand DNA and the recombinase) searches and identifies a region of homology in intact duplex DNA. The broken single-strand DNA displaces the like strand and forms Watson-Crick base pairs with its complement, forming a duplex in which each strand is from one of the two recombining DNA molecules.


go_id: GO:0098531
term: ligand-activated transcription factor activity
ontology: MF
definition:
A DNA-binding transcription factor activity regulated by binding to a ligand and that modulates the transcription of specific gene sets. Examples include the lac and trp repressors in E.coli and steroid hormone receptors.


go_id: GO:0098532
term: histone H3-K27 trimethylation
ontology: BP
definition:
The modification of histone H3 by addition of three methyl groups to lysine at position 27 of the histone.


go_id: GO:0098533
term: ATPase dependent transmembrane transport complex
ontology: CC
definition:
A transmembrane protein complex that functions in ATPase dependent active transport across a membrane.


go_id: GO:0098535
term: de novo centriole assembly involved in multi-ciliated epithelial cell differentiation
ontology: BP
definition:
Centriole assembly in which a centriole arises de novo by a process involving an electron-dense structure known as a deuterosome, rather than by duplication of an existing centriole, and occurring as part of multi-ciliated epithelial cell differentiation.


go_id: GO:0098536
term: deuterosome
ontology: CC
definition:
A spherical, electron dense, cytoplasmic structure that is involved in de novo assembly of centrioles.


go_id: GO:0098542
term: defense response to other organism
ontology: BP
definition:
Reactions triggered in response to the presence of another organism that act to protect the cell or organism from damage caused by that organism.


go_id: GO:0098543
term: detection of other organism
ontology: BP
definition:
The series of events in which a stimulus from another organism is received and converted into a molecular signal.


go_id: GO:0098544
term: maintenance of protein complex location
ontology: BP
definition:
Any process in which a protein complex is maintained in a location and prevented from moving elsewhere. These include sequestration, stabilization to prevent transport elsewhere and the active retrieval of protein complexes that move away.


go_id: GO:0098545
term: maintenance of protein complex location in cytoplasm
ontology: BP
definition:
Any process in which a protein complex is maintained in a specific location within the cytoplasm and is prevented from moving elsewhere.


go_id: GO:0098549
term: somatic ring canal
ontology: CC
definition:
A stable intercellular bridge between somatic cells.  Examples include the intercellular bridges between ovarian follicle cells in insects and between imaginal disc cells in insects.


go_id: GO:0098552
term: side of membrane
ontology: CC
definition:
A cellular component consisting of one leaflet of a membrane bilayer and any proteins embedded or anchored in it or attached to its surface.


go_id: GO:0098561
term: methyl accepting chemotaxis protein complex
ontology: CC
definition:
A transmembrane protein complex that consists of multiple methyl-accepting chemoreceptor protein subunits, a histidine kinase and a connector protein and which functions in the regulation of flagellar rotary motor activity in response to an external chemical stimulus.


go_id: GO:0098563
term: intrinsic component of synaptic vesicle membrane
ontology: CC
definition:
The component of the synaptic vesicle membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0098567
term: periplasmic side of plasma membrane
ontology: CC
definition:
The side (leaflet) of a plasma membrane that faces the periplasm, and all proteins embedded in it or attached to its surface.


go_id: GO:0098568
term: external side of mycolate outer membrane
ontology: CC
definition:
The side (leaflet) of the mycolate outer membrane that faces the environment and any proteins embedded in it or loosely bound to its surface.


go_id: GO:0098569
term: internal side of mycolate outer membrane
ontology: CC
definition:
The side of the mycolate outer membrane that faces the cell wall peptidoglycan. It is rich in long-chain mycolic acids (hydroxylated branched-chain fatty acids) that are covalently linked to the cell wall peptidoglycan via an arabinogalactan network.


go_id: GO:0098570
term: stromal side of plastid inner membrane
ontology: CC
definition:
The side (leaflet) of the plastid inner membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface.


go_id: GO:0098571
term: lumenal side of plastid thylakoid membrane
ontology: CC
definition:
The side (leaflet) of the plastid thylakoid membrane that faces the lumen, and any proteins embedded in it or loosely bound to its surface.


go_id: GO:0098572
term: stromal side of plastid thylakoid membrane
ontology: CC
definition:
The side (leaflet) of the plastid thylakoid membrane that faces the stroma, and any proteins embedded in it or loosely bound to its surface.


go_id: GO:0098573
term: intrinsic component of mitochondrial membrane
ontology: CC
definition:
The component of the mitochondrial membrane consisting of the gene products and protein complexes having either part of their peptide sequence embedded in the hydrophobic region of the membrane or some other covalently attached group such as a GPI anchor that is similarly embedded in the membrane.


go_id: GO:0098578
term: condensed chromatin of inactivated sex chromosome
ontology: CC
definition:
A condensed form of chromatin that is associated with an inactivated sex chromosome and which is responsible for its inactivation.


go_id: GO:0098581
term: detection of external biotic stimulus
ontology: BP
definition:
The series of events in which an external biotic stimulus is detected and converted into a molecular signal.  An external biotic stimulus is defined as one caused or produced by a living organism other than the one being stimulated.


go_id: GO:0098584
term: host cell synaptic vesicle
ontology: CC
definition:
A secretory organelle of a host cell, some 50 nm in diameter, of presynaptic nerve terminals; accumulates in high concentrations of neurotransmitters and secretes these into the synaptic cleft by fusion with the 'active zone' of the presynaptic plasma membrane.


go_id: GO:0098586
term: cellular response to virus
ontology: BP
definition:
Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus from a virus.


go_id: GO:0098591
term: external side of apical plasma membrane
ontology: CC
definition:
The leaflet the apical region of the plasma membrane that faces away from the cytoplasm and any proteins embedded or anchored in it or attached to its surface.


go_id: GO:0098593
term: goblet cell theca
ontology: CC
definition:
A cup shaped specialization of the cytoskeleton that forms a thin layer located just below the apical mass of mature mucin secretory granules in the cytoplasm of goblet cells of the intestinal epithelium.  It consists of an orderly network of intermediate filaments and microtubules. Microtubules are arranged vertically, like barrel staves, along the inner aspect of the theta. Intermediate filaments form two networks: an inner, basketlike network and an outer series of circumferential bundles resembling the hoops of a barrel.


go_id: GO:0098595
term: perivitelline space
ontology: CC
definition:
The space between the membrane of an oocyte and a surrounding membranous structure (zona pellucida or perivitelline membrane).


go_id: GO:0098598
term: learned vocalization behavior or vocal learning
ontology: BP
definition:
Vocalisation behavior that is the result of learning, or the process by which new vocalizations are learned.


go_id: GO:0098600
term: selenomethionine gamma-lyase activity
ontology: MF
definition:
Catalysis of the reaction: L-Selenomethionine + H2O => Methaneselenol + Ammonia + 2-oxobutanoic acid.


go_id: GO:0098601
term: selenomethionine adenosyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: ATP + L-Selenomethionine + H2O => Orthophosphate + Diphosphate + Se-Adenosylselenomethionine.


go_id: GO:0098603
term: selenol Se-methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: R + Se-Adenosylselenomethionine => CH3-R + Se-Adenosyl-L-selenohomocysteine.


go_id: GO:0098604
term: adenosylselenohomocysteinase activity
ontology: MF
definition:
Catalysis of the reaction: Se-Adenosyl-L-selenohomocysteine + H2O => Adenosine + Selenohomocysteine.


go_id: GO:0098606
term: selenocystathionine gamma-lyase activity
ontology: MF
definition:
Catalysis of the reaction: L-Selenocystathionine + H2O => L-Selenocysteine + NH3 + 2-Oxobutanoic acid.


go_id: GO:0098613
term: methaneselenol methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + methaneselenol => S-adenosyl-L-homocysteine + dimethyl selenide.


go_id: GO:0098614
term: hydrogen selenide methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + hydrogen selenide => S-adenosyl-L-homocysteine + methaneselenol.


go_id: GO:0098615
term: dimethyl selenide methyltransferase activity
ontology: MF
definition:
Catalysis of the reaction: S-adenosyl-L-methionine + dimethyl selenide => S-adenosyl-L-homocysteine + trimethylselenonium.


go_id: GO:0098618
term: selenomethionine-tRNA ligase activity
ontology: MF
definition:
Catalysis of the reaction: ATP + L-selenomethionine + tRNA(Met) => AMP + diphosphate + selenomethionyl-tRNA(Met).


go_id: GO:0098621
term: phosphoseryl-selenocysteinyl-tRNA selenium transferase activity
ontology: MF
definition:
Catalysis of the reaction: O-phosphoseryl-tRNA(Sec) + selenophosphoric acid + H2O => L-selenocysteinyl-tRNA(Sec) + 2 phosphoric acid.


go_id: GO:0098622
term: selenodiglutathione-disulfide reductase activity
ontology: MF
definition:
Catalysis of the reaction: H+ + selenodiglutathione + NADPH => gluthathioselenol + glutathione + NADP+.


go_id: GO:0098624
term: 3'-phosphoadenylylselenate reductase activity
ontology: MF
definition:
Catalysis of the reaction: 3'-phosphoadenylylselenate + NADPH => adenosine 3',5'-bisphosphate + selenite + NADP+ + H+.


go_id: GO:0098629
term: trans-Golgi network membrane organization
ontology: BP
definition:
A process which results in the assembly, arrangement of constituent parts, or disassembly of a trans-Golgi network membrane.


