================================================================================ WGCNA MODULE ANNOTATION SUMMARY ================================================================================ ================================================================================ MODULE 0 ================================================================================ Total orthologs: 760 Orthologs with annotations: 271 Annotation coverage: 35.7% GO BIOLOGICAL PROCESS (Top 10) -------------------------------------------------------------------------------- 22 regulation of transcription by RNA polymerase II [GO:0006357] 16 negative regulation of transcription by RNA polymerase II [GO:0000122] 14 positive regulation of transcription by RNA polymerase II [GO:0045944] 14 positive regulation of DNA-templated transcription [GO:0045893] 12 signal transduction [GO:0007165] 11 cilium assembly [GO:0060271] 11 apoptotic process [GO:0006915] 9 negative regulation of DNA-templated transcription [GO:0045892] 9 protein ubiquitination [GO:0016567] 9 protein transport [GO:0015031] Total unique GO BP terms: 1367 GO CELLULAR COMPONENT (Top 10) -------------------------------------------------------------------------------- 95 cytoplasm [GO:0005737] 79 nucleus [GO:0005634] 70 cytosol [GO:0005829] 49 nucleoplasm [GO:0005654] 48 plasma membrane [GO:0005886] 26 membrane [GO:0016020] 24 mitochondrion [GO:0005739] 18 endoplasmic reticulum membrane [GO:0005789] 17 chromatin [GO:0000785] 16 extracellular space [GO:0005615] Total unique GO CC terms: 360 GO MOLECULAR FUNCTION (Top 10) -------------------------------------------------------------------------------- 42 zinc ion binding [GO:0008270] 41 ATP binding [GO:0005524] 29 metal ion binding [GO:0046872] 22 DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981] 17 RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] 17 identical protein binding [GO:0042802] 16 DNA binding [GO:0003677] 15 RNA binding [GO:0003723] 13 protein homodimerization activity [GO:0042803] 12 chromatin binding [GO:0003682] Total unique GO MF terms: 462 GO SLIM TERMS / PHYSIOLOGICAL PATHWAYS (Top 10) -------------------------------------------------------------------------------- 175 organelle 115 catalytic activity 80 nucleus 75 anatomical structure development 70 cytosol 52 regulation of DNA-templated transcription 50 catalytic activity, acting on a protein 49 plasma membrane 49 nucleoplasm 47 DNA binding Total unique GO Slim terms: 120 GENE FUNCTIONS / PROTEIN NAMES (Top 10) -------------------------------------------------------------------------------- 2 Plasma kallikrein (EC 3.4.21.34) (Fletcher factor) (Kininogenin) (Plasma prekallikrein) [Cleaved into: Plasma kallikrein heavy chain; Plasma kallikrein light chain] 2 Endothelin-converting enzyme 1 (ECE-1) (EC 3.4.24.71) 2 Kinesin-like protein KIF16B (Sorting nexin-23) 2 Fibroblast growth factor 16 (FGF-16) 2 H2.0-like homeobox protein (Homeobox protein HLX1) 2 MICAL-like protein 2 (Junctional Rab13-binding protein) (Molecule interacting with CasL-like 2) (MICAL-L2) 1 Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (Neuropeptide G-protein coupled receptor) 1 Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) 1 Receptor-type tyrosine-protein phosphatase F (EC 3.1.3.48) 1 Multiple PDZ domain protein (Multi-PDZ domain protein 1) Total unique protein names: 265 ================================================================================ MODULE 1 ================================================================================ Total orthologs: 2649 Orthologs with annotations: 963 Annotation coverage: 36.4% GO BIOLOGICAL PROCESS (Top 10) -------------------------------------------------------------------------------- 45 cell division [GO:0051301] 36 negative regulation of transcription by RNA polymerase II [GO:0000122] 35 proteolysis [GO:0006508] 34 cilium assembly [GO:0060271] 33 protein transport [GO:0015031] 33 positive regulation of transcription by RNA polymerase II [GO:0045944] 33 DNA repair [GO:0006281] 30 DNA damage response [GO:0006974] 28 regulation of transcription by RNA polymerase II [GO:0006357] 26 positive regulation of DNA-templated transcription [GO:0045893] Total unique GO BP terms: 3273 GO CELLULAR COMPONENT (Top 10) -------------------------------------------------------------------------------- 318 cytoplasm [GO:0005737] 318 nucleus [GO:0005634] 277 cytosol [GO:0005829] 194 nucleoplasm [GO:0005654] 160 plasma membrane [GO:0005886] 123 mitochondrion [GO:0005739] 103 membrane [GO:0016020] 73 endoplasmic reticulum membrane [GO:0005789] 70 centrosome [GO:0005813] 64 nucleolus [GO:0005730] Total unique GO CC terms: 705 GO MOLECULAR FUNCTION (Top 10) -------------------------------------------------------------------------------- 115 ATP binding [GO:0005524] 99 metal ion binding [GO:0046872] 94 identical protein binding [GO:0042802] 89 zinc ion binding [GO:0008270] 68 RNA binding [GO:0003723] 47 protein homodimerization activity [GO:0042803] 46 DNA binding [GO:0003677] 36 calcium ion binding [GO:0005509] 34 ATP hydrolysis activity [GO:0016887] 33 chromatin binding [GO:0003682] Total unique GO MF terms: 1157 GO SLIM TERMS / PHYSIOLOGICAL PATHWAYS (Top 10) -------------------------------------------------------------------------------- 702 organelle 445 catalytic activity 319 nucleus 277 cytosol 194 nucleoplasm 189 hydrolase activity 185 anatomical structure development 180 transferase activity 165 plasma membrane 163 catalytic activity, acting on a protein Total unique GO Slim terms: 129 GENE FUNCTIONS / PROTEIN NAMES (Top 10) -------------------------------------------------------------------------------- 3 Hemicentin-1 (Fibulin-6) (FIBL-6) 3 Myosin regulatory light polypeptide 9 (20 kDa myosin light chain) (LC20) (MLC-2C) (Myosin RLC) (Myosin regulatory light chain 2, smooth muscle isoform) (Myosin regulatory light chain 9) (Myosin regulatory light chain MRLC1) 2 Polyunsaturated fatty acid 5-lipoxygenase (EC 1.13.11.-) (Arachidonate 5-lipoxygenase) (5-LO) (5-lipoxygenase) (EC 1.13.11.34) 2 Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) (G-protein coupled receptor PGR25) [Cleaved into: Adhesion G-protein coupled receptor D1, N-terminal fragment (ADGRD1 N-terminal fragment); Adhesion G-protein coupled receptor D1, C-terminal fragment (ADGRD1 C-terminal fragment)] 2 Octopamine receptor beta-2R (DmOct-beta-12) (DmOct-beta-2R) 2 Protein lin-7 homolog C (Lin-7C) 2 Adhesion G-protein coupled receptor D1 (G-protein coupled receptor 133) [Cleaved into: Adhesion G-protein coupled receptor D1, N-terminal fragment (ADGRD1 N-terminal fragment); Adhesion G-protein coupled receptor D1, C-terminal fragment (ADGRD1 C-terminal fragment)] 2 DNA repair protein XRCC1 (X-ray repair cross-complementing protein 1) 2 Peroxisomal sarcosine oxidase (PSO) (EC 1.5.3.1) (EC 1.5.3.7) (L-pipecolate oxidase) (L-pipecolic acid oxidase) 2 Nucleoprotein TPR (NPC-associated intranuclear protein) (Translocated promoter region and nuclear basket protein) Total unique protein names: 941 ================================================================================ MODULE 2 ================================================================================ Total orthologs: 1200 Orthologs with annotations: 516 Annotation coverage: 43.0% GO BIOLOGICAL PROCESS (Top 10) -------------------------------------------------------------------------------- 40 positive regulation of transcription by RNA polymerase II [GO:0045944] 29 positive regulation of DNA-templated transcription [GO:0045893] 28 protein ubiquitination [GO:0016567] 28 regulation of transcription by RNA polymerase II [GO:0006357] 25 negative regulation of transcription by RNA polymerase II [GO:0000122] 24 cell differentiation [GO:0030154] 19 negative regulation of apoptotic process [GO:0043066] 19 proteolysis [GO:0006508] 18 intracellular signal transduction [GO:0035556] 15 apoptotic process [GO:0006915] Total unique GO BP terms: 2465 GO CELLULAR COMPONENT (Top 10) -------------------------------------------------------------------------------- 182 cytoplasm [GO:0005737] 138 cytosol [GO:0005829] 133 nucleus [GO:0005634] 130 plasma membrane [GO:0005886] 84 membrane [GO:0016020] 72 nucleoplasm [GO:0005654] 42 endoplasmic reticulum membrane [GO:0005789] 41 endoplasmic reticulum [GO:0005783] 38 mitochondrion [GO:0005739] 34 Golgi apparatus [GO:0005794] Total unique GO CC terms: 464 GO MOLECULAR FUNCTION (Top 10) -------------------------------------------------------------------------------- 73 ATP binding [GO:0005524] 61 zinc ion binding [GO:0008270] 60 metal ion binding [GO:0046872] 51 identical protein binding [GO:0042802] 31 DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981] 29 RNA polymerase II cis-regulatory region sequence-specific DNA binding [GO:0000978] 28 calcium ion binding [GO:0005509] 27 protein serine kinase activity [GO:0106310] 24 protein homodimerization activity [GO:0042803] 22 protein serine/threonine kinase activity [GO:0004674] Total unique GO MF terms: 749 GO SLIM TERMS / PHYSIOLOGICAL PATHWAYS (Top 10) -------------------------------------------------------------------------------- 326 organelle 238 catalytic activity 139 cytosol 133 nucleus 132 plasma membrane 131 anatomical structure development 114 transferase activity 114 catalytic activity, acting on a protein 102 hydrolase activity 81 cell differentiation Total unique GO Slim terms: 124 GENE FUNCTIONS / PROTEIN NAMES (Top 10) -------------------------------------------------------------------------------- 4 Homeobox protein Nkx-2.2a (Homeobox protein NK-2 homolog B-A) 3 Extracellular calcium-sensing receptor (CaSR) (Parathyroid cell calcium-sensing receptor) (PCaR1) (RaKCaR) 2 Potassium voltage-gated channel protein Shaw (Shaw2) 2 SH3 and multiple ankyrin repeat domains protein 2 (Shank2) (Cortactin-binding protein 1) (CortBP1) (Proline-rich synapse-associated protein 1) 2 Synaptotagmin-6 (Synaptotagmin VI) (SytVI) 2 Protein DD3-3 2 Prolyl 4-hydroxylase subunit alpha-1 (4-PH alpha-1) (EC 1.14.11.2) (Procollagen-proline,2-oxoglutarate-4-dioxygenase subunit alpha-1) 2 Mucin-5AC (MUC-5AC) (Gastric mucin) (Major airway glycoprotein) (Mucin-5 subtype AC, tracheobronchial) (Tracheobronchial mucin) (TBM) 2 Gamma-aminobutyric acid type B receptor subunit 2 (GABA-B receptor 2) (GABA-B-R2) (GABA-BR2) (GABABR2) (Gb2) (G-protein coupled receptor 51) (HG20) 2 G-protein coupled receptor 161 Total unique protein names: 501 ================================================================================ MODULE 3 ================================================================================ Total orthologs: 1148 Orthologs with annotations: 397 Annotation coverage: 34.6% GO BIOLOGICAL PROCESS (Top 10) -------------------------------------------------------------------------------- 21 protein transport [GO:0015031] 20 proteolysis [GO:0006508] 18 cilium assembly [GO:0060271] 18 regulation of transcription by RNA polymerase II [GO:0006357] 16 negative regulation of transcription by RNA polymerase II [GO:0000122] 16 positive regulation of transcription by RNA polymerase II [GO:0045944] 14 spermatogenesis [GO:0007283] 14 signal transduction [GO:0007165] 14 positive regulation of DNA-templated transcription [GO:0045893] 12 apoptotic process [GO:0006915] Total unique GO BP terms: 1841 GO CELLULAR COMPONENT (Top 10) -------------------------------------------------------------------------------- 136 cytoplasm [GO:0005737] 114 nucleus [GO:0005634] 97 plasma membrane [GO:0005886] 95 cytosol [GO:0005829] 67 nucleoplasm [GO:0005654] 44 mitochondrion [GO:0005739] 43 membrane [GO:0016020] 28 centrosome [GO:0005813] 27 endoplasmic reticulum [GO:0005783] 27 endoplasmic reticulum membrane [GO:0005789] Total unique GO CC terms: 423 GO MOLECULAR FUNCTION (Top 10) -------------------------------------------------------------------------------- 61 ATP binding [GO:0005524] 46 metal ion binding [GO:0046872] 43 identical protein binding [GO:0042802] 34 zinc ion binding [GO:0008270] 22 protein serine kinase activity [GO:0106310] 22 calcium ion binding [GO:0005509] 19 ATP hydrolysis activity [GO:0016887] 18 RNA binding [GO:0003723] 17 protein serine/threonine kinase activity [GO:0004674] 15 protein homodimerization activity [GO:0042803] Total unique GO MF terms: 620 GO SLIM TERMS / PHYSIOLOGICAL PATHWAYS (Top 10) -------------------------------------------------------------------------------- 273 organelle 191 catalytic activity 114 nucleus 99 plasma membrane 95 cytosol 92 catalytic activity, acting on a protein 84 transferase activity 82 hydrolase activity 81 anatomical structure development 67 nucleoplasm Total unique GO Slim terms: 127 GENE FUNCTIONS / PROTEIN NAMES (Top 10) -------------------------------------------------------------------------------- 2 Radial spoke head 1 homolog (Male meiotic metaphase chromosome-associated acidic protein) (Meichroacidin) (Testis-specific gene A2 protein) 2 Advillin (Peripheral nervous system villin-like protein) (Pervin) 2 Tetraspanin-33 (Tspan-33) 2 Mitogen-activated protein kinase kinase kinase 4 (EC 2.7.11.25) (MAP three kinase 1) (MAPK/ERK kinase kinase 4) (MEK kinase 4) (MEKK 4) 2 PR domain zinc finger protein 13 (EC 2.1.1.-) (PR domain-containing protein 13) 2 Galactosylceramide sulfotransferase (GalCer sulfotransferase) (EC 2.8.2.11) (3'-phosphoadenosine-5'-phosphosulfate:GalCer sulfotransferase) (3'-phosphoadenylylsulfate:galactosylceramide 3'-sulfotransferase) (Cerebroside sulfotransferase) 2 Hemicentin-1 (Fibulin-6) (FIBL-6) 2 Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain] 2 Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) 2 A-type voltage-gated potassium channel KCND2 (Potassium voltage-gated channel subfamily D member 2) (Voltage-gated potassium channel subunit Kv4.2) Total unique protein names: 386 ================================================================================ MODULE 4 ================================================================================ Total orthologs: 970 Orthologs with annotations: 405 Annotation coverage: 41.8% GO BIOLOGICAL PROCESS (Top 10) -------------------------------------------------------------------------------- 21 positive regulation of transcription by RNA polymerase II [GO:0045944] 17 negative regulation of transcription by RNA polymerase II [GO:0000122] 16 apoptotic process [GO:0006915] 15 protein ubiquitination [GO:0016567] 15 proteolysis [GO:0006508] 14 negative regulation of DNA-templated transcription [GO:0045892] 14 regulation of transcription by RNA polymerase II [GO:0006357] 14 G protein-coupled receptor signaling pathway [GO:0007186] 14 signal transduction [GO:0007165] 13 neurogenesis [GO:0022008] Total unique GO BP terms: 2121 GO CELLULAR COMPONENT (Top 10) -------------------------------------------------------------------------------- 123 plasma membrane [GO:0005886] 117 cytoplasm [GO:0005737] 116 nucleus [GO:0005634] 113 cytosol [GO:0005829] 78 membrane [GO:0016020] 60 nucleoplasm [GO:0005654] 35 mitochondrion [GO:0005739] 33 endoplasmic reticulum [GO:0005783] 29 extracellular region [GO:0005576] 25 glutamatergic synapse [GO:0098978] Total unique GO CC terms: 425 GO MOLECULAR FUNCTION (Top 10) -------------------------------------------------------------------------------- 64 ATP binding [GO:0005524] 54 zinc ion binding [GO:0008270] 44 identical protein binding [GO:0042802] 40 metal ion binding [GO:0046872] 32 calcium ion binding [GO:0005509] 27 protein homodimerization activity [GO:0042803] 23 protein serine kinase activity [GO:0106310] 23 RNA binding [GO:0003723] 22 protein serine/threonine kinase activity [GO:0004674] 17 DNA binding [GO:0003677] Total unique GO MF terms: 651 GO SLIM TERMS / PHYSIOLOGICAL PATHWAYS (Top 10) -------------------------------------------------------------------------------- 264 organelle 194 catalytic activity 125 plasma membrane 116 nucleus 113 cytosol 103 anatomical structure development 98 transferase activity 96 catalytic activity, acting on a protein 73 hydrolase activity 69 cell differentiation Total unique GO Slim terms: 122 GENE FUNCTIONS / PROTEIN NAMES (Top 10) -------------------------------------------------------------------------------- 4 Putative histone-lysine N-methyltransferase PRDM6 (EC 2.1.1.361) (PR domain zinc finger protein 6) (PR domain-containing protein 6) (PR domain-containing protein in smooth muscle) 3 Potassium voltage-gated channel protein Shal (Shaker cognate l) (Shal2) 3 Protocadherin Fat 4 (FAT tumor suppressor homolog 4) (Fat-like cadherin protein FAT-J) 2 E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71) 2 Transient receptor potential cation channel subfamily A member 1 (Ankyrin-like with transmembrane domains protein 1) (Wasabi receptor) 2 [F-actin]-monooxygenase MICAL3 (EC 1.14.13.225) (Molecule interacting with CasL protein 3) (MICAL-3) 2 Acid-sensing ion channel 1C (ASIC1-C) (Acid-sensing ion channel 1.3-C) (Amiloride-sensitive cation channel 2-C, neuronal-C) (ZASIC1.3) 2 Vesicular inhibitory amino acid transporter (GABA and glycine transporter) (Solute carrier family 32 member 1) (Vesicular GABA transporter) 2 Neuropeptide FF receptor 2 (G-protein coupled receptor 74) (G-protein coupled receptor HLWAR77) (Neuropeptide G-protein coupled receptor) 1 Neuropilin-2 (Vascular endothelial cell growth factor 165 receptor 2) Total unique protein names: 392 ================================================================================ MODULE 5 ================================================================================ Total orthologs: 891 Orthologs with annotations: 427 Annotation coverage: 47.9% GO BIOLOGICAL PROCESS (Top 10) -------------------------------------------------------------------------------- 35 positive regulation of transcription by RNA polymerase II [GO:0045944] 27 regulation of transcription by RNA polymerase II [GO:0006357] 23 negative regulation of transcription by RNA polymerase II [GO:0000122] 22 positive regulation of DNA-templated transcription [GO:0045893] 20 positive regulation of gene expression [GO:0010628] 17 protein transport [GO:0015031] 17 apoptotic process [GO:0006915] 17 cell division [GO:0051301] 16 intracellular signal transduction [GO:0035556] 16 signal transduction [GO:0007165] Total unique GO BP terms: 2431 GO CELLULAR COMPONENT (Top 10) -------------------------------------------------------------------------------- 132 cytoplasm [GO:0005737] 132 plasma membrane [GO:0005886] 121 nucleus [GO:0005634] 116 cytosol [GO:0005829] 75 nucleoplasm [GO:0005654] 73 membrane [GO:0016020] 44 endoplasmic reticulum [GO:0005783] 42 endoplasmic reticulum membrane [GO:0005789] 40 mitochondrion [GO:0005739] 37 Golgi apparatus [GO:0005794] Total unique GO CC terms: 452 GO MOLECULAR FUNCTION (Top 10) -------------------------------------------------------------------------------- 68 ATP binding [GO:0005524] 57 zinc ion binding [GO:0008270] 41 metal ion binding [GO:0046872] 38 calcium ion binding [GO:0005509] 33 identical protein binding [GO:0042802] 25 protein serine kinase activity [GO:0106310] 24 protein homodimerization activity [GO:0042803] 24 RNA binding [GO:0003723] 22 protein serine/threonine kinase activity [GO:0004674] 18 DNA binding [GO:0003677] Total unique GO MF terms: 679 GO SLIM TERMS / PHYSIOLOGICAL PATHWAYS (Top 10) -------------------------------------------------------------------------------- 297 organelle 200 catalytic activity 133 plasma membrane 123 anatomical structure development 122 nucleus 116 cytosol 108 catalytic activity, acting on a protein 102 transferase activity 76 cell differentiation 76 hydrolase activity Total unique GO Slim terms: 121 GENE FUNCTIONS / PROTEIN NAMES (Top 10) -------------------------------------------------------------------------------- 5 Hemicentin-1 (Fibulin-6) (FIBL-6) 2 Potassium voltage-gated channel protein Shaw (Shaw2) 2 EF-hand calcium-binding domain-containing protein 6 (CAP-binding protein complex-interacting protein 1) (DJ-1-binding protein) (DJBP) 2 Alpha-adducin (Erythrocyte adducin subunit alpha) 2 Myoferlin (Fer-1-like protein 3) 2 Xaa-Pro aminopeptidase 1 (EC 3.4.11.9) (Aminoacylproline aminopeptidase) (Cytosolic aminopeptidase P) (Soluble aminopeptidase P) (sAmp) (X-Pro aminopeptidase 1) (X-prolyl aminopeptidase 1, soluble) 2 Major facilitator superfamily domain-containing protein 12 2 Low-density lipoprotein receptor-related protein 6 (LRP-6) 2 E3 ubiquitin-protein ligase TRIM71 (EC 2.3.2.27) (Protein lin-41 homolog) (RING-type E3 ubiquitin transferase TRIM71) (Tripartite motif-containing protein 71) 2 Ankyrin repeat and sterile alpha motif domain-containing protein 1B (Amyloid-beta protein intracellular domain-associated protein 1) (AIDA-1) (E2A-PBX1-associated protein) (EB-1) Total unique protein names: 413 ================================================================================ MODULE 6 ================================================================================ Total orthologs: 878 Orthologs with annotations: 314 Annotation coverage: 35.8% GO BIOLOGICAL PROCESS (Top 10) -------------------------------------------------------------------------------- 15 negative regulation of transcription by RNA polymerase II [GO:0000122] 14 cell division [GO:0051301] 12 protein transport [GO:0015031] 11 DNA repair [GO:0006281] 10 protein ubiquitination [GO:0016567] 9 apoptotic process [GO:0006915] 9 protein stabilization [GO:0050821] 9 positive regulation of transcription by RNA polymerase II [GO:0045944] 8 negative regulation of apoptotic process [GO:0043066] 8 negative regulation of DNA-templated transcription [GO:0045892] Total unique GO BP terms: 1474 GO CELLULAR COMPONENT (Top 10) -------------------------------------------------------------------------------- 106 nucleus [GO:0005634] 91 cytosol [GO:0005829] 83 cytoplasm [GO:0005737] 59 nucleoplasm [GO:0005654] 51 plasma membrane [GO:0005886] 42 mitochondrion [GO:0005739] 36 membrane [GO:0016020] 30 endoplasmic reticulum [GO:0005783] 26 endoplasmic reticulum membrane [GO:0005789] 20 extracellular exosome [GO:0070062] Total unique GO CC terms: 390 GO MOLECULAR FUNCTION (Top 10) -------------------------------------------------------------------------------- 36 metal ion binding [GO:0046872] 35 ATP binding [GO:0005524] 32 zinc ion binding [GO:0008270] 30 identical protein binding [GO:0042802] 19 RNA binding [GO:0003723] 19 protein homodimerization activity [GO:0042803] 15 DNA binding [GO:0003677] 15 calcium ion binding [GO:0005509] 13 GTP binding [GO:0005525] 10 protein heterodimerization activity [GO:0046982] Total unique GO MF terms: 579 GO SLIM TERMS / PHYSIOLOGICAL PATHWAYS (Top 10) -------------------------------------------------------------------------------- 228 organelle 163 catalytic activity 106 nucleus 91 cytosol 61 hydrolase activity 60 transferase activity 59 nucleoplasm 53 catalytic activity, acting on a protein 52 plasma membrane 44 anatomical structure development Total unique GO Slim terms: 120 GENE FUNCTIONS / PROTEIN NAMES (Top 10) -------------------------------------------------------------------------------- 2 Glutathione hydrolase 1 proenzyme (EC 3.4.19.13) (Gamma-glutamyltransferase 1) (Gamma-glutamyltranspeptidase 1) (GGT 1) (EC 2.3.2.2) (Leukotriene-C4 hydrolase) (EC 3.4.19.14) (CD antigen CD224) [Cleaved into: Glutathione hydrolase 1 heavy chain; Glutathione hydrolase 1 light chain] 2 GON-4-like protein (GON-4 homolog) (Protein GON4) 2 Beta-1,4-N-acetylgalactosaminyltransferase 3 (B4GalNAcT3) (Beta4GalNAc-T3) (Beta4GalNAcT3) (EC 2.4.1.244) (Beta-1,4-N-acetylgalactosaminyltransferase III) (N-acetyl-beta-glucosaminyl-glycoprotein 4-beta-N-acetylgalactosaminyltransferase 2) (NGalNAc-T2) 1 Target of rapamycin complex 2 subunit MAPKAP1 (TORC2 subunit MAPKAP1) (Mitogen-activated protein kinase 2-associated protein 1) (Stress-activated map kinase-interacting protein 1) (SAPK-interacting protein 1) 1 Transcription factor HES-4-B (Hairy and enhancer of split 4-B) (Protein hairy-2) (Xhairy2) (Protein hairy-2a) (Xhairy2b) 1 Dehydrogenase/reductase SDR family member 6 (EC 1.1.1.-) ((R)-beta-hydroxybutyrate dehydrogenase) (3-hydroxybutyrate dehydrogenase type 2) (EC 1.1.1.30) (4-oxo-L-proline reductase) (EC 1.1.1.104) (Oxidoreductase UCPA) (Short chain dehydrogenase/reductase family 15C member 1) 1 Melanoma-associated antigen D2 (11B6) (Breast cancer-associated gene 1 protein) (BCG-1) (Hepatocellular carcinoma-associated protein JCL-1) (MAGE-D2 antigen) 1 Cyclic GMP-AMP phosphodiesterase SMPDL3A (2',3'-cGAMP phosphodiesterase SMPDL3A) (EC 3.1.4.-) (Acid sphingomyelinase-like phosphodiesterase 3a) (ASM-like phosphodiesterase 3a) (EC 3.6.1.15) 1 Histone deacetylase 3 (HD3) (EC 3.5.1.98) (Protein deacetylase HDAC3) (EC 3.5.1.-) (Protein deacylase HDAC3) (EC 3.5.1.-) 1 ATPase ASNA1 homolog (EC 3.6.-.-) (Arsenical pump-driving ATPase homolog) (Arsenite-stimulated ATPase) Total unique protein names: 311 ================================================================================ MODULE 7 ================================================================================ Total orthologs: 706 Orthologs with annotations: 275 Annotation coverage: 39.0% GO BIOLOGICAL PROCESS (Top 10) -------------------------------------------------------------------------------- 16 proteolysis [GO:0006508] 13 negative regulation of transcription by RNA polymerase II [GO:0000122] 13 positive regulation of transcription by RNA polymerase II [GO:0045944] 12 protein transport [GO:0015031] 11 intracellular signal transduction [GO:0035556] 11 negative regulation of cell population proliferation [GO:0008285] 11 inflammatory response [GO:0006954] 10 cell division [GO:0051301] 9 protein ubiquitination [GO:0016567] 9 cell population proliferation [GO:0008283] Total unique GO BP terms: 1591 GO CELLULAR COMPONENT (Top 10) -------------------------------------------------------------------------------- 84 cytoplasm [GO:0005737] 77 cytosol [GO:0005829] 71 nucleus [GO:0005634] 70 plasma membrane [GO:0005886] 49 membrane [GO:0016020] 39 nucleoplasm [GO:0005654] 37 endoplasmic reticulum membrane [GO:0005789] 28 Golgi apparatus [GO:0005794] 27 endoplasmic reticulum [GO:0005783] 23 Golgi membrane [GO:0000139] Total unique GO CC terms: 331 GO MOLECULAR FUNCTION (Top 10) -------------------------------------------------------------------------------- 46 ATP binding [GO:0005524] 32 metal ion binding [GO:0046872] 29 identical protein binding [GO:0042802] 29 zinc ion binding [GO:0008270] 17 protein homodimerization activity [GO:0042803] 15 protein serine/threonine kinase activity [GO:0004674] 14 protein serine kinase activity [GO:0106310] 13 calcium ion binding [GO:0005509] 12 protein kinase activity [GO:0004672] 10 ATP hydrolysis activity [GO:0016887] Total unique GO MF terms: 530 GO SLIM TERMS / PHYSIOLOGICAL PATHWAYS (Top 10) -------------------------------------------------------------------------------- 177 organelle 157 catalytic activity 78 cytosol 77 transferase activity 71 nucleus 71 plasma membrane 71 catalytic activity, acting on a protein 64 hydrolase activity 61 anatomical structure development 39 lipid metabolic process Total unique GO Slim terms: 114 GENE FUNCTIONS / PROTEIN NAMES (Top 10) -------------------------------------------------------------------------------- 2 Isoaspartyl peptidase/L-asparaginase (EC 3.4.19.5) (EC 3.5.1.1) (Asparaginase-like protein 1) (Beta-aspartyl-peptidase) (Isoaspartyl dipeptidase) (L-asparagine amidohydrolase) [Cleaved into: Isoaspartyl peptidase/L-asparaginase alpha chain; Isoaspartyl peptidase/L-asparaginase beta chain] 2 Solute carrier family 49 member 4 (Disrupted in renal cancer protein 2) (Disrupted in renal carcinoma protein 2) 2 Growth factor receptor-bound protein 2 (Adapter protein GRB2) (SH2/SH3 adapter GRB2) 1 RNA helicase Mov10l1 (EC 3.6.4.13) (Moloney leukemia virus 10-like protein 1) (MOV10-like protein 1) 1 PDZ domain-containing protein GIPC1 (GAIP C-terminus-interacting protein) (GLUT1 C-terminal-binding protein) (GLUT1CBP) (RGS-GAIP-interacting protein) (RGS19-interacting protein 1) (Synectin) 1 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-4 (EC 3.1.4.11) (Phosphoinositide phospholipase C-delta-4) (Phospholipase C-delta-4) (PLC-delta-4) 1 Dual specificity testis-specific protein kinase 2 (EC 2.7.12.1) (Testicular protein kinase 2) 1 Putative phosphatidate phosphatase (EC 3.1.3.4) (Germ cell guidance factor) (Phosphatidic acid phosphatase type 2) (Protein wunen) 1 5'-AMP-activated protein kinase catalytic subunit alpha-2 (AMPK subunit alpha-2) (EC 2.7.11.1) (Acetyl-CoA carboxylase kinase) (ACACA kinase) (Hydroxymethylglutaryl-CoA reductase kinase) (HMGCR kinase) (EC 2.7.11.31) 1 Cystinosin Total unique protein names: 272 ================================================================================ MODULE 8 ================================================================================ Total orthologs: 256 Orthologs with annotations: 102 Annotation coverage: 39.8% GO BIOLOGICAL PROCESS (Top 10) -------------------------------------------------------------------------------- 10 mRNA splicing, via spliceosome [GO:0000398] 8 positive regulation of transcription by RNA polymerase II [GO:0045944] 8 RNA splicing [GO:0008380] 7 negative regulation of transcription by RNA polymerase II [GO:0000122] 6 cilium assembly [GO:0060271] 6 protein stabilization [GO:0050821] 6 mRNA processing [GO:0006397] 6 chromatin remodeling [GO:0006338] 5 negative regulation of DNA-templated transcription [GO:0045892] 5 positive regulation of DNA-templated transcription [GO:0045893] Total unique GO BP terms: 480 GO CELLULAR COMPONENT (Top 10) -------------------------------------------------------------------------------- 40 nucleus [GO:0005634] 34 cytoplasm [GO:0005737] 31 nucleoplasm [GO:0005654] 31 cytosol [GO:0005829] 11 nuclear speck [GO:0016607] 8 nucleolus [GO:0005730] 8 membrane [GO:0016020] 8 cilium [GO:0005929] 8 centrosome [GO:0005813] 7 spliceosomal complex [GO:0005681] Total unique GO CC terms: 193 GO MOLECULAR FUNCTION (Top 10) -------------------------------------------------------------------------------- 24 RNA binding [GO:0003723] 15 ATP binding [GO:0005524] 13 zinc ion binding [GO:0008270] 9 metal ion binding [GO:0046872] 9 DNA binding [GO:0003677] 7 GTP binding [GO:0005525] 7 identical protein binding [GO:0042802] 6 GTPase activity [GO:0003924] 6 ATP hydrolysis activity [GO:0016887] 6 chromatin binding [GO:0003682] Total unique GO MF terms: 176 GO SLIM TERMS / PHYSIOLOGICAL PATHWAYS (Top 10) -------------------------------------------------------------------------------- 74 organelle 40 nucleus 35 catalytic activity 32 RNA binding 31 nucleoplasm 31 cytosol 21 regulation of DNA-templated transcription 19 hydrolase activity 18 anatomical structure development 17 mRNA metabolic process Total unique GO Slim terms: 92 GENE FUNCTIONS / PROTEIN NAMES (Top 10) -------------------------------------------------------------------------------- 2 Protein phosphatase 1 regulatory subunit 12A (Myosin phosphatase-targeting subunit 1) (Myosin phosphatase target subunit 1) (Protein phosphatase myosin-binding subunit) 2 Msx2-interacting protein (SMART/HDAC1-associated repressor protein) (SPEN homolog) 2 Protein AF-10 (ALL1-fused gene from chromosome 10 protein) 2 Centrosomal protein of 164 kDa (Cep164) 1 Guanine nucleotide-binding protein-like 3 homolog (Nucleostemin-1) 1 Ubiquitin-conjugating enzyme E2 R2 (EC 2.3.2.23) (E2 ubiquitin-conjugating enzyme R2) (Ubiquitin carrier protein R2) (Ubiquitin-conjugating enzyme E2-CDC34B) (Ubiquitin-protein ligase R2) 1 Coiled-coil and C2 domain-containing protein 2A 1 Splicing factor Cactin (Renal carcinoma antigen NY-REN-24) 1 Proline-rich protein PRCC (Papillary renal cell carcinoma translocation-associated gene protein) 1 Peptidyl-prolyl cis-trans isomerase FKBP5 (PPIase FKBP5) (EC 5.2.1.8) (51 kDa FK506-binding protein) (51 kDa FKBP) (FKBP-51) (FK506-binding protein 5) (FKBP-5) (Rotamase) Total unique protein names: 98 ================================================================================ MODULE 9 ================================================================================ Total orthologs: 84 Orthologs with annotations: 40 Annotation coverage: 47.6% GO BIOLOGICAL PROCESS (Top 10) -------------------------------------------------------------------------------- 5 signal transduction [GO:0007165] 4 positive regulation of transcription by RNA polymerase II [GO:0045944] 3 translation [GO:0006412] 2 positive regulation of proteasomal ubiquitin-dependent protein catabolic process [GO:0032436] 2 proteasome-mediated ubiquitin-dependent protein catabolic process [GO:0043161] 2 chordate embryonic development [GO:0043009] 2 protein folding [GO:0006457] 2 protein stabilization [GO:0050821] 2 endoplasmic reticulum to Golgi vesicle-mediated transport [GO:0006888] 2 intracellular protein transport [GO:0006886] Total unique GO BP terms: 191 GO CELLULAR COMPONENT (Top 10) -------------------------------------------------------------------------------- 21 cytosol [GO:0005829] 18 nucleus [GO:0005634] 16 cytoplasm [GO:0005737] 6 plasma membrane [GO:0005886] 5 perinuclear region of cytoplasm [GO:0048471] 5 endoplasmic reticulum membrane [GO:0005789] 4 nucleoplasm [GO:0005654] 4 protein-containing complex [GO:0032991] 4 nucleolus [GO:0005730] 3 ribonucleoprotein complex [GO:1990904] Total unique GO CC terms: 106 GO MOLECULAR FUNCTION (Top 10) -------------------------------------------------------------------------------- 7 RNA binding [GO:0003723] 5 ATP binding [GO:0005524] 4 identical protein binding [GO:0042802] 3 GTP binding [GO:0005525] 3 GTPase activity [GO:0003924] 3 ribosome binding [GO:0043022] 3 metal ion binding [GO:0046872] 3 ATP hydrolysis activity [GO:0016887] 3 DNA binding [GO:0003677] 3 calcium ion binding [GO:0005509] Total unique GO MF terms: 98 GO SLIM TERMS / PHYSIOLOGICAL PATHWAYS (Top 10) -------------------------------------------------------------------------------- 30 organelle 21 cytosol 18 nucleus 16 catalytic activity 9 RNA binding 8 DNA binding 8 hydrolase activity 8 anatomical structure development 8 regulation of DNA-templated transcription 7 catalytic activity, acting on a protein Total unique GO Slim terms: 73 GENE FUNCTIONS / PROTEIN NAMES (Top 10) -------------------------------------------------------------------------------- 1 UV excision repair protein RAD23 homolog A (HR23A) (mHR23A) 1 Elongation factor 2b (EF-2) (EC 3.6.5.-) 1 Peptidyl-prolyl cis-trans isomerase B (PPIase B) (EC 5.2.1.8) (Cyclophilin B) (Rotamase B) (S-cyclophilin) (SCYLP) 1 Coatomer subunit beta (Beta-coat protein) (Beta-COP) 1 Small ribosomal subunit protein RACK1 (Guanine nucleotide-binding protein subunit beta-2-like 1) [Cleaved into: Small ribosomal subunit protein RACK1, N-terminally processed (Guanine nucleotide-binding protein subunit beta-2-like 1, N-terminally processed)] 1 Methylmalonic aciduria type A protein, mitochondrial (EC 3.6.-.-) 1 LIM domain only protein 7 (LMO-7) (F-box only protein 20) (LOMP) 1 Protein transport protein Sec24C (SEC24-related protein C) 1 Ras GTPase-activating protein-binding protein 1 (G3BP-1) (EC 3.6.4.12) (EC 3.6.4.13) (ATP-dependent DNA/RNA helicase G3BP) 1 Heat shock protein HSP 90-beta Total unique protein names: 40 ================================================================================ MODULE 10 ================================================================================ Total orthologs: 63 Orthologs with annotations: 26 Annotation coverage: 41.3% GO BIOLOGICAL PROCESS (Top 10) -------------------------------------------------------------------------------- 3 positive regulation of cell population proliferation [GO:0008284] 3 regulation of transcription by RNA polymerase II [GO:0006357] 2 proteolysis [GO:0006508] 2 gluconeogenesis [GO:0006094] 2 malate metabolic process [GO:0006108] 2 malate-aspartate shuttle [GO:0043490] 2 tricarboxylic acid cycle [GO:0006099] 2 angiogenesis [GO:0001525] 2 chromatin remodeling [GO:0006338] 2 negative regulation of cell differentiation [GO:0045596] Total unique GO BP terms: 131 GO CELLULAR COMPONENT (Top 10) -------------------------------------------------------------------------------- 10 nucleus [GO:0005634] 7 mitochondrion [GO:0005739] 5 cytoplasm [GO:0005737] 4 membrane [GO:0016020] 4 nucleoplasm [GO:0005654] 3 mitochondrial matrix [GO:0005759] 3 mitochondrial inner membrane [GO:0005743] 3 endoplasmic reticulum [GO:0005783] 2 plasma membrane [GO:0005886] 2 cytosolic large ribosomal subunit [GO:0022625] Total unique GO CC terms: 74 GO MOLECULAR FUNCTION (Top 10) -------------------------------------------------------------------------------- 4 metal ion binding [GO:0046872] 3 RNA binding [GO:0003723] 2 protein homodimerization activity [GO:0042803] 2 structural constituent of ribosome [GO:0003735] 2 chromatin binding [GO:0003682] 2 transcription coactivator activity [GO:0003713] 1 RNA polymerase II C-terminal domain binding [GO:0099122] 1 aminopeptidase activity [GO:0004177] 1 initiator methionyl aminopeptidase activity [GO:0004239] 1 metalloaminopeptidase activity [GO:0070006] Total unique GO MF terms: 55 GO SLIM TERMS / PHYSIOLOGICAL PATHWAYS (Top 10) -------------------------------------------------------------------------------- 19 organelle 10 nucleus 8 catalytic activity 7 mitochondrion 6 regulation of DNA-templated transcription 5 catalytic activity, acting on a protein 5 RNA binding 4 nucleoplasm 4 molecular function regulator activity 4 chromatin organization Total unique GO Slim terms: 53 GENE FUNCTIONS / PROTEIN NAMES (Top 10) -------------------------------------------------------------------------------- 1 Regulation of nuclear pre-mRNA domain-containing protein 2 1 Methionine aminopeptidase 2 (MAP 2) (MetAP 2) (EC 3.4.11.18) (Initiation factor 2-associated 67 kDa glycoprotein) (p67) (p67eIF2) (Peptidase M) 1 N-alpha-acetyltransferase 10 (EC 2.3.1.255) (N-terminal acetyltransferase complex ARD1 subunit homolog A) (NatA catalytic subunit Naa10) 1 Malate dehydrogenase, mitochondrial (EC 1.1.1.37) 1 Histone deacetylase complex subunit SAP18 (18 kDa Sin3-associated polypeptide) (Sin3-associated polypeptide p18) 1 Mitochondrial 2-oxoglutarate/malate carrier protein (OGCP) (alpha-oxoglutarate carrier) (Solute carrier family 25 member 11) (SLC25A11) 1 EGFR adapter protein 1 Large ribosomal subunit protein uL14 (60S ribosomal protein L23) 1 ATP synthase F(1) complex catalytic subunit beta, mitochondrial (EC 7.1.2.2) (ATP synthase F1 subunit beta) 1 SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 1 (60 kDa BRG-1/Brm-associated factor subunit A) (BRG1-associated factor 60A) (BAF60A) (SWI/SNF complex 60 kDa subunit) Total unique protein names: 26 ================================================================================ MODULE 11 ================================================================================ Total orthologs: 64 Orthologs with annotations: 19 Annotation coverage: 29.7% GO BIOLOGICAL PROCESS (Top 10) -------------------------------------------------------------------------------- 4 flagellated sperm motility [GO:0030317] 3 sperm axoneme assembly [GO:0007288] 3 epithelial cilium movement involved in extracellular fluid movement [GO:0003351] 2 DNA damage response [GO:0006974] 2 signal transduction [GO:0007165] 2 protein folding [GO:0006457] 2 spermatid development [GO:0007286] 2 cell differentiation [GO:0030154] 2 spermatogenesis [GO:0007283] 2 protein localization [GO:0008104] Total unique GO BP terms: 124 GO CELLULAR COMPONENT (Top 10) -------------------------------------------------------------------------------- 10 cytosol [GO:0005829] 8 cytoplasm [GO:0005737] 6 nucleus [GO:0005634] 5 extracellular region [GO:0005576] 5 axoneme [GO:0005930] 4 membrane [GO:0016020] 3 mitochondrion [GO:0005739] 3 sperm flagellum [GO:0036126] 2 microtubule [GO:0005874] 2 nucleoplasm [GO:0005654] Total unique GO CC terms: 52 GO MOLECULAR FUNCTION (Top 10) -------------------------------------------------------------------------------- 4 ATP binding [GO:0005524] 2 alpha-tubulin binding [GO:0043014] 1 magnesium ion binding [GO:0000287] 1 p53 binding [GO:0002039] 1 protein kinase activator activity [GO:0030295] 1 protein kinase binding [GO:0019901] 1 protein serine kinase activity [GO:0106310] 1 protein serine/threonine kinase activity [GO:0004674] 1 metal ion binding [GO:0046872] 1 riboflavin kinase activity [GO:0008531] Total unique GO MF terms: 53 GO SLIM TERMS / PHYSIOLOGICAL PATHWAYS (Top 10) -------------------------------------------------------------------------------- 19 organelle 10 cytosol 7 catalytic activity 7 reproductive process 6 nucleus 6 anatomical structure development 5 extracellular region 5 cilium 5 microtubule-based movement 4 catalytic activity, acting on a protein Total unique GO Slim terms: 54 GENE FUNCTIONS / PROTEIN NAMES (Top 10) -------------------------------------------------------------------------------- 1 Serine/threonine-protein kinase STK11 (EC 2.7.11.1) (Liver kinase B1 homolog) (LKB1) 1 Riboflavin kinase (EC 2.7.1.26) (ATP:riboflavin 5'-phosphotransferase) (Flavokinase) 1 Dipeptidyl peptidase 9 (EC 3.4.14.5) 1 Heat shock protein 105 kDa (Antigen NY-CO-25) (Heat shock 110 kDa protein) (Heat shock protein family H member 1) 1 Coiled-coil domain-containing protein 146 1 Thioredoxin reductase 3 (EC 1.8.1.9) (Thioredoxin and glutathione reductase) (Thioredoxin reductase TR2) 1 DnaJ homolog subfamily B member 13 (Testis and spermatogenesis cell-related protein 6) (Testis spermatocyte apoptosis-related gene 6 protein) (Testis spermatogenesis apoptosis-related gene 3 protein) (Testis spermatogenesis apoptosis-related gene 6 protein) 1 Parkin coregulated gene protein 1 Chloride intracellular channel protein 2 (Glutaredoxin-like oxidoreductase CLIC2) (EC 1.8.-.-) (Glutaredoxin-like peroxidase CLIC2) (EC 1.11.1.-) (XAP121) 1 Radial spoke head protein 3 homolog (A-kinase anchor protein RSPH3) (Radial spoke head-like protein 2) Total unique protein names: 19 ================================================================================ MODULE 12 ================================================================================ Total orthologs: 62 Orthologs with annotations: 24 Annotation coverage: 38.7% GO BIOLOGICAL PROCESS (Top 10) -------------------------------------------------------------------------------- 3 negative regulation of transcription by RNA polymerase II [GO:0000122] 3 positive regulation of MAPK cascade [GO:0043410] 3 positive regulation of transcription by RNA polymerase II [GO:0045944] 3 apoptotic process [GO:0006915] 3 positive regulation of DNA-templated transcription [GO:0045893] 3 rhythmic process [GO:0048511] 2 cell population proliferation [GO:0008283] 2 epithelial to mesenchymal transition [GO:0001837] 2 in utero embryonic development [GO:0001701] 2 positive regulation of neuron differentiation [GO:0045666] Total unique GO BP terms: 291 GO CELLULAR COMPONENT (Top 10) -------------------------------------------------------------------------------- 12 cytosol [GO:0005829] 10 cytoplasm [GO:0005737] 8 plasma membrane [GO:0005886] 7 nucleus [GO:0005634] 5 membrane [GO:0016020] 4 nucleoplasm [GO:0005654] 3 perinuclear region of cytoplasm [GO:0048471] 3 mitochondrion [GO:0005739] 3 Golgi apparatus [GO:0005794] 2 receptor complex [GO:0043235] Total unique GO CC terms: 60 GO MOLECULAR FUNCTION (Top 10) -------------------------------------------------------------------------------- 6 ATP binding [GO:0005524] 5 zinc ion binding [GO:0008270] 4 identical protein binding [GO:0042802] 3 RNA binding [GO:0003723] 2 protein homodimerization activity [GO:0042803] 2 SH2 domain binding [GO:0042169] 2 signaling receptor binding [GO:0005102] 2 ubiquitin protein ligase binding [GO:0031625] 2 GTPase activator activity [GO:0005096] 2 chromatin binding [GO:0003682] Total unique GO MF terms: 103 GO SLIM TERMS / PHYSIOLOGICAL PATHWAYS (Top 10) -------------------------------------------------------------------------------- 14 organelle 12 cytosol 11 catalytic activity 9 anatomical structure development 8 plasma membrane 8 cell differentiation 7 nucleus 7 transferase activity 6 catalytic activity, acting on a protein 5 regulation of DNA-templated transcription Total unique GO Slim terms: 65 GENE FUNCTIONS / PROTEIN NAMES (Top 10) -------------------------------------------------------------------------------- 1 Fibroblast growth factor receptor 1 (FGFR-1) (bFGF-R-1) (EC 2.7.10.1) (Basic fibroblast growth factor receptor 1) (MFR) (Proto-oncogene c-Fgr) (CD antigen CD331) 1 Solute carrier organic anion transporter family member 4A1 (Organic anion-transporting polypeptide E) (OATP-E) (Sodium-independent organic anion transporter E) (Solute carrier family 21 member 12) 1 TNF receptor-associated factor 4 (EC 2.3.2.27) (Cysteine-rich domain associated with RING and Traf domains protein 1) (Metastatic lymph node gene 62 protein) (MLN 62) (RING finger protein 83) 1 ADP-ribosylation factor GTPase-activating protein 1 (ARF GAP 1) (ADP-ribosylation factor 1 GTPase-activating protein) (ARF1 GAP) (ARF1-directed GTPase-activating protein) 1 A-kinase anchor protein 1, mitochondrial (A-kinase anchor protein 149 kDa) (AKAP 149) (Dual specificity A-kinase-anchoring protein 1) (D-AKAP-1) (Protein kinase A-anchoring protein 1) (PRKA1) (Spermatid A-kinase anchor protein 84) (S-AKAP84) 1 Ubiquitin conjugation factor E4 A (EC 2.3.2.27) (RING-type E3 ubiquitin transferase E4 A) 1 Protein Wnt-1 1 SH3 and PX domain-containing protein 2B (Factor for adipocyte differentiation 49) (Tyrosine kinase substrate with four SH3 domains) 1 CREB-binding protein (Histone lysine acetyltransferase CREBBP) (EC 2.3.1.48) (Protein lactyltransferas CREBBP) (EC 2.3.1.-) (Protein-lysine acetyltransferase CREBBP) (EC 2.3.1.-) 1 Somatostatin receptor type 2 (SS-2-R) (SS2-R) (SS2R) (SST2) (SRIF-1) Total unique protein names: 24 ================================================================================ MODULE 13 ================================================================================ Total orthologs: 50 Orthologs with annotations: 8 Annotation coverage: 16.0% GO BIOLOGICAL PROCESS (Top 10) -------------------------------------------------------------------------------- 3 proteolysis [GO:0006508] 1 peptide metabolic process [GO:0006518] 1 protein processing [GO:0016485] 1 positive regulation of blood pressure [GO:0045777] 1 positive regulation of flagellated sperm motility [GO:1902093] 1 positive regulation of heart rate [GO:0010460] 1 positive regulation of uterine smooth muscle contraction [GO:0070474] 1 regulation of dopamine metabolic process [GO:0042053] 1 regulation of feeding behavior [GO:0060259] 1 response to cocaine [GO:0042220] Total unique GO BP terms: 56 GO CELLULAR COMPONENT (Top 10) -------------------------------------------------------------------------------- 4 plasma membrane [GO:0005886] 2 extracellular space [GO:0005615] 2 membrane [GO:0016020] 2 Golgi membrane [GO:0000139] 2 transport vesicle membrane [GO:0030658] 1 dendrite membrane [GO:0032590] 1 neuronal cell body membrane [GO:0032809] 1 sperm midpiece [GO:0097225] 1 trans-Golgi network [GO:0005802] 1 cytoplasm [GO:0005737] Total unique GO CC terms: 33 GO MOLECULAR FUNCTION (Top 10) -------------------------------------------------------------------------------- 3 zinc ion binding [GO:0008270] 3 metal ion binding [GO:0046872] 2 metalloendopeptidase activity [GO:0004222] 1 metallocarboxypeptidase activity [GO:0004181] 1 tachykinin receptor activity [GO:0004995] 1 glutamyl aminopeptidase activity [GO:0004230] 1 metalloaminopeptidase activity [GO:0070006] 1 peptide binding [GO:0042277] 1 calcium channel activity [GO:0005262] 1 glutamate binding [GO:0016595] Total unique GO MF terms: 19 GO SLIM TERMS / PHYSIOLOGICAL PATHWAYS (Top 10) -------------------------------------------------------------------------------- 6 catalytic activity 5 catalytic activity, acting on a protein 4 plasma membrane 4 hydrolase activity 3 molecular transducer activity 2 extracellular space 2 protein maturation 2 organelle 2 transferase activity 1 transporter activity Total unique GO Slim terms: 28 GENE FUNCTIONS / PROTEIN NAMES (Top 10) -------------------------------------------------------------------------------- 1 Carboxypeptidase D (EC 3.4.17.22) (Metallocarboxypeptidase D) (gp180) (p170) 1 Neuromedin-K receptor (NKR) (NK-3 receptor) (NK-3R) (Neurokinin B receptor) (Tachykinin receptor 3) 1 Endothelin-converting enzyme 2 (ECE-2) (EC 3.4.24.71) 1 Aminopeptidase A (AP-A) (APA) (EC 3.4.11.7) (Glutamyl aminopeptidase) (EAP) 1 Glutamate receptor ionotropic, NMDA 2B (GluN2B) (Glutamate [NMDA] receptor subunit epsilon-2) (N-methyl D-aspartate receptor subtype 2B) (NMDAR2B) (NR2B) 1 Tyrosine-protein kinase transmembrane receptor ROR2 (EC 2.7.10.1) (Neurotrophic tyrosine kinase, receptor-related 2) 1 Heparan sulfate 2-O-sulfotransferase hst-2 (Heparan sulfotransferase 2) (EC 2.8.2.-) (HS2ST1 homolog) 1 A disintegrin and metalloproteinase with thrombospondin motifs 16 (ADAM-TS 16) (ADAM-TS16) (ADAMTS-16) (EC 3.4.24.-) Total unique protein names: 8 ================================================================================ MODULE 14 ================================================================================ Total orthologs: 46 Orthologs with annotations: 14 Annotation coverage: 30.4% GO BIOLOGICAL PROCESS (Top 10) -------------------------------------------------------------------------------- 4 intracellular signal transduction [GO:0035556] 4 positive regulation of transcription by RNA polymerase II [GO:0045944] 3 regulation of transcription by RNA polymerase II [GO:0006357] 2 cell population proliferation [GO:0008283] 2 MAPK cascade [GO:0000165] 2 mRNA processing [GO:0006397] 2 mRNA transport [GO:0051028] 2 response to lipopolysaccharide [GO:0032496] 2 negative regulation of transcription by RNA polymerase II [GO:0000122] 2 response to heat [GO:0009408] Total unique GO BP terms: 144 GO CELLULAR COMPONENT (Top 10) -------------------------------------------------------------------------------- 9 nucleus [GO:0005634] 6 cytoplasm [GO:0005737] 6 cytosol [GO:0005829] 4 nucleoplasm [GO:0005654] 2 ribonucleoprotein complex [GO:1990904] 2 plasma membrane [GO:0005886] 2 perinuclear region of cytoplasm [GO:0048471] 2 cell-cell junction [GO:0005911] 2 endoplasmic reticulum membrane [GO:0005789] 1 P-body [GO:0000932] Total unique GO CC terms: 45 GO MOLECULAR FUNCTION (Top 10) -------------------------------------------------------------------------------- 4 zinc ion binding [GO:0008270] 3 DNA binding [GO:0003677] 3 ATP binding [GO:0005524] 3 protein serine kinase activity [GO:0106310] 3 protein serine/threonine kinase activity [GO:0004674] 3 sequence-specific DNA binding [GO:0043565] 2 magnesium ion binding [GO:0000287] 2 protein kinase binding [GO:0019901] 2 DNA-binding transcription factor activity [GO:0003700] 2 DNA-binding transcription factor activity, RNA polymerase II-specific [GO:0000981] Total unique GO MF terms: 45 GO SLIM TERMS / PHYSIOLOGICAL PATHWAYS (Top 10) -------------------------------------------------------------------------------- 11 organelle 9 nucleus 7 regulation of DNA-templated transcription 6 cytosol 6 anatomical structure development 5 DNA binding 5 catalytic activity 5 transcription regulator activity 4 nucleoplasm 3 cell differentiation Total unique GO Slim terms: 39 GENE FUNCTIONS / PROTEIN NAMES (Top 10) -------------------------------------------------------------------------------- 1 mRNA decay activator protein ZFP36L1 (Butyrate response factor 1) (EGF-response factor 1) (ERF-1) (TPA-induced sequence 11b) (Zinc finger protein 36, C3H1 type-like 1) (ZFP36-like 1) 1 Ribosomal protein S6 kinase alpha-3 (S6K-alpha-3) (EC 2.7.11.1) (90 kDa ribosomal protein S6 kinase 3) (p90-RSK 3) (p90RSK3) (MAP kinase-activated protein kinase 1b) (MAPK-activated protein kinase 1b) (MAPKAP kinase 1b) (MAPKAPK-1b) (Ribosomal S6 kinase 2) (RSK-2) (pp90RSK2) 1 DnaJ homolog subfamily B member 4 (Heat shock 40 kDa protein 1 homolog) (HSP40 homolog) (Heat shock protein 40 homolog) (Human liver DnaJ-like protein) 1 Protein gustavus 1 Deformed epidermal autoregulatory factor 1 (Protein DEAF-1) 1 Mitogen-activated protein kinase 15 (EC 2.7.11.24) 1 Cytochrome P450 3A24 (EC 1.14.14.1) (CYPIIIA24) 1 Ras-related protein Rab-30 (EC 3.6.5.2) 1 Scavenger receptor cysteine-rich domain-containing protein DMBT1 (Apactin) (CRP-ductin) (Deleted in malignant brain tumors 1 protein) (Glycoprotein 300) (gp300) (Hensin) (Mucin-like glycoprotein) (Muclin) (Vomeroglandin) (p80) 1 Transcriptional-regulating factor 1 (Breast cancer anti-estrogen resistance 2) (Transcriptional-regulating protein 132) (Zinc finger protein rapa) (Zinc finger transcription factor TReP-132) Total unique protein names: 14