[2020-04-26 07:21:55.313] [jointLog] [info] Fragment incompatibility prior below threshold.  Incompatible fragments will be ignored.
[2020-04-26 07:21:55.313] [jointLog] [info] Usage of --validateMappings implies use of minScoreFraction. Since not explicitly specified, it is being set to 0.65
[2020-04-26 07:21:55.313] [jointLog] [info] Usage of --validateMappings implies a default consensus slack of 0.2. Setting consensusSlack to 0.35.
[2020-04-26 07:21:55.313] [jointLog] [info] parsing read library format
[2020-04-26 07:21:55.313] [jointLog] [info] There is 1 library.
[2020-04-26 07:21:55.371] [jointLog] [info] Loading pufferfish index
[2020-04-26 07:21:55.371] [jointLog] [info] Loading dense pufferfish index.
[2020-04-26 07:21:55.493] [jointLog] [info] done
[2020-04-26 07:21:55.493] [jointLog] [info] Index contained 40,435 targets
[2020-04-26 07:21:55.507] [jointLog] [info] Number of decoys : 0
[2020-04-26 07:22:05.110] [jointLog] [info] Computed 93,527 rich equivalence classes for further processing
[2020-04-26 07:22:05.110] [jointLog] [info] Counted 3,186,382 total reads in the equivalence classes 
[2020-04-26 07:22:05.131] [jointLog] [info] Number of mappings discarded because of alignment score : 1,265,421
[2020-04-26 07:22:05.131] [jointLog] [info] Number of fragments entirely discarded because of alignment score : 26,413
[2020-04-26 07:22:05.131] [jointLog] [info] Number of fragments discarded because they are best-mapped to decoys : 0
[2020-04-26 07:22:05.131] [jointLog] [info] Number of fragments discarded because they have only dovetail (discordant) mappings to valid targets : 5,312
[2020-04-26 07:22:05.135] [jointLog] [warning] Only 3186382 fragments were mapped, but the number of burn-in fragments was set to 5000000.
The effective lengths have been computed using the observed mappings.

[2020-04-26 07:22:05.135] [jointLog] [info] Mapping rate = 99.1442%

[2020-04-26 07:22:05.135] [jointLog] [info] finished quantifyLibrary()
[2020-04-26 07:22:05.137] [jointLog] [info] Starting optimizer
[2020-04-26 07:22:05.169] [jointLog] [info] Marked 0 weighted equivalence classes as degenerate
[2020-04-26 07:22:05.179] [jointLog] [info] iteration = 0 | max rel diff. = 7295.8
[2020-04-26 07:22:05.110] [fileLog] [info] 
At end of round 0
==================
Observed 3213886 total fragments (3213886 in most recent round)

[2020-04-26 07:22:05.629] [jointLog] [info] iteration = 100 | max rel diff. = 13.4681
[2020-04-26 07:22:06.084] [jointLog] [info] iteration = 200 | max rel diff. = 2.82041
[2020-04-26 07:22:06.534] [jointLog] [info] iteration = 300 | max rel diff. = 0.315199
[2020-04-26 07:22:06.987] [jointLog] [info] iteration = 400 | max rel diff. = 0.244708
[2020-04-26 07:22:07.439] [jointLog] [info] iteration = 500 | max rel diff. = 0.0934327
[2020-04-26 07:22:07.612] [jointLog] [info] iteration = 539 | max rel diff. = 0.00664314
[2020-04-26 07:22:07.614] [jointLog] [info] Finished optimizer
[2020-04-26 07:22:07.614] [jointLog] [info] writing output